Lateral Sclerosis malady

NIH Rare Diseases: Primary lateral sclerosis is a type of motor neuron disease, where nerve cells that control voluntary muscle movement breakdown and die. In primary lateral sclerosis only the upper motor neurons in the brain are affected. Symptoms often begin with problems in the legs (e.g., weakness, stiffness, spasticity, and balance problems), but may also start with hand clumsiness and changes in speech. The symptoms worsen gradually over time, however people with this condition have a normal life expectancy. Progression of symptoms varies from person to person, some people retain the ability to walk without assistance, others eventually require assistive devices such as canes or wheelchairs. Diagnosis requires extensive testing to exclude other diseases. Treatment may include baclofen and tizanidine to reduce spasticity, quinine or phenytoin to reduce cramps, as well as physical and speech therapy as required.³⁰

MalaCards: Lateral Sclerosis, also known as primary lateral sclerosis, is related to amyotrophic lateral sclerosis and neuronitis. An important gene associated with Lateral Sclerosis is ALS2 (amyotrophic lateral sclerosis 2 (juvenile)), and among its related pathways are Amyotrophic lateral sclerosis (ALS) and Neuroscience. The compounds calcium and oxygen have been mentioned in the context of this disorder. Affiliated tissues include whole blood, brain and cortex, and related mouse phenotypes are cellular and nervous system.

NINDS: Primary lateral sclerosis (PLS) is a rare neuromuscular disease with slowly progressive weakness in voluntary muscle movement. PLS belongs to a group of disorders known as motor neuron diseases. PLS affects the upper motor neurons (also called corticospinal neurons) in the arms, legs, and face. ³¹

Aliases & Descriptions:

lateral sclerosis 6 8 43 primary lateral sclerosis 6 7 30 31 32

primary lateral sclerosis (disorder) 6

Diseases related to lateral sclerosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 912)

id	Related Disease	Score	Top Affiliating Genes
1	amyotrophic lateral sclerosis	87.9	ZNF512B, ZNF746, SH2D3C, RFK, CNR1, CNR2
2	neuronitis	68.6	ZNF746, CNR1, CNR2, CNTF, CNTFR, CNTN4
3	alzheimer's disease	56.8	CNR1, CNR2, CNTF, CNTFR, CNTN4, PCSK1N
4	amyotrophic lateral sclerosis (als)	53.3	CNTF, SETX, VGF, VEGFA, RAB5A, RAC1
5	neurodegeneration	48.9	ZNF746, CNR1, CNR2, CNTF, SERPINE2, SETD2
6	dementia	48.8	PCSK1N, SERPINE1, VEGFA, LPA, LPL, VCP
7	neurodegenerative disease	48.2	CNR1, CNTF, SETD2, NAIP, LPL, VCP
8	leukemia	46.9	CNR1, CNR2, CNTF, CNTFR, KIFAP3, SELE
9	neuroblastoma	46.4	CNR1, CNTF, CNTFR, CNTN6, SERPINE2, SETD2
10	prostatitis	45.6	CNR1, CNR2, CNTF, CNTN6, KIFAP3, BTBD10
11	cerebritis	44.4	CNR1, CNTF, CNTN4, SELE, SERPINE2, SETD2
12	hypoxia	44.3	RBM3, SELE, SELL, SETD2, SERPINE1, BSG
13	parkinson's disease	42.5	CNR1, CNTF, VCP, BLVRB, PAWR, PARK7
14	neuropathy	42.1	CNR1, CNTF, CNTFR, SELE, SETX, SERPINE1
15	motor neuron disease	41.9	CNTF, SETX, NAIP, VEGFA, VCP, VAPB
16	multiple sclerosis	40.8	RFK, CNR1, CNR2, CNTF, SELE, SELL
17	down syndrome	39.2	CNR1, CNR2, SERPINE1, VEGFA, VDAC2, RAB5A
18	frontotemporal dementia	39.0	PCSK1N, VCP, PARK2, BDNF, SCG2, CHGB
19	cervicitis	38.9	CNR1, RBMS1, SELE, SETD2, SERPINE1, BSG
20	muscular atrophy	38.0	CNTF, NAIP, VAPB, UTRN, BCL2, BCL2L1
21	myeloma	36.9	CNTF, CNTFR, SELL, SETD2, VEGFA, VDR
22	blindness	36.2	CNR1, CNTF, SELE, SERPINE1, VEGFA, LPL
23	paralysis	35.7	CNTF, SETX, NAIP, VCP, VAPB, PARK2
24	multiple myeloma	35.7	CNTF, SETD2, VEGFA, RAC1, LIF, BID
25	multiple system atrophy	34.8	RAB5A, PARK7, PARK2, BDNF, CHAT, MT3
26	spinal muscular atrophy	34.0	CNTF, NAIP, UTRN, SCO2, CHAT, IGHMBP2
27	spasticity	33.2	CNR1, VEGFA, VDR, RAC1, PANK2, MTHFR
28	tauopathy	32.8	PARK7, PARK2, CDK5, INA, GRN, APP
29	amyloidosis	32.5	LPA, LPL, PARK2, BCL2, B2M, ATXN1
30	chorea	32.1	BDNF, ATN1, MAP2, HTT, CACNA1B, NTS
31	neuromuscular disease	31.9	NAIP, UTRN, PABPN1, CHKB, MB, HSPB8
32	breast cancer	30.9	VEGFA, VDR, KDR, BCL2, MTHFR, XRCC1
33	schizophrenia	30.5	MTHFR, GRIP1, MAOA, HTR2A, AKT1, TNF
34	macroglobulinemia	30.3	VEGFA, LPL, BCL2, BAX, XBP1, B2M
35	hemochromatosis	30.3	CHMP2B, S100B, B2M, GSTP1, APOE, CCL2
36	acromegaly	29.4	SERPINE1, VEGFA, LPA, LPL, CHGA, MMP2
37	carcinoma	28.6	CNR1, CNR2, CNTF, RCC1, VPS54, NBEAL1
38	pancreatitis	25.8	CNR1, CNR2, PCSK1N, BTBD10, SELE, SERPINE2
39	ischemia	24.0	CNR1, CNR2, CNTF, SELE, SELL, SETD2
40	retinitis	23.1	CNR1, CNR2, CNTF, CNTFR, KIFAP3, RDH14
41	melanoma	22.4	CNTF, RBM3, SELE, SETD2, SERPINE1, BSG
42	adenocarcinoma	22.3	CNR1, NBEAL1, SELE, SELL, SETD2, SERPINE1
43	malaria	21.7	RFK, CNTF, RBMS1, NBEAL1, SELE, SETD2
44	thyroiditis	21.6	CNR2, CNTN4, SELE, SETD2, SERPINE1, BSG
45	gonococcal synovitis	21.5	CNR1, CNR2, CNTF, SELE, SELL, SETD2
46	colorectal cancer	21.5	CNR1, CNR2, CNTN4, CNTN6, SELE, SERPINE2
47	hepatocellular carcinoma	21.0	CNR1, CNR2, VPS54, SELE, SETD2, SERPINE1
48	ovarian cancer	20.9	CNTN4, CNTN6, RBM3, SELE, SETD2, SERPINE1
49	ataxia	20.6	CNR2, CNTN4, KIFAP3, SETD2, SETX, SERPINE1
50	cholesterol	20.5	CNR1, CNR2, SELE, SELL, SERPINE1, BSG

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to lateral sclerosis:

²²

MGI Mouse Phenotypes related to lateral sclerosis:

²⁵ (show all 28)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular phenotype	MP:0005384	20.8	SH2D3C, CNR1, CNTF, KIFAP3, VPS54, RBM3
2	nervous system phenotype	MP:0003631	20.5	SH2D3C, CNR1, CNTF, CNTFR, CNTN6, VPS54
3	mortality/aging	MP:0010768	20.0	SH2D3C, RFK, CNR1, CNTFR, KIFAP3, VPS54
4	homeostasis/metabolism phenotype	MP:0005376	19.9	RFK, CNR1, CNTF, KIFAP3, VPS54, RBMS1
5	behavior/neurological phenotype	MP:0005386	19.7	SH2D3C, CNR1, CNTF, CNTFR, CNTN6, KIFAP3
6	growth/size phenotype	MP:0005378	18.4	CNR1, PCSK1N, VPS54, RBMS1, SELE, SETD2
7	cardiovascular system phenotype	MP:0005385	16.6	KIFAP3, VPS54, SELE, SELL, SETD2, SERPINE1
8	normal phenotype	MP:0002873	16.1	SELE, NAIP, VEGFA, PAWR, BDNF, KDR
9	muscle phenotype	MP:0005369	16.0	CNTF, KIFAP3, VPS54, VEGFA, LPL, VCP
10	immune system phenotype	MP:0005387	15.5	SH2D3C, RFK, CNR2, CNTF, KIFAP3, RBM3
11	integument phenotype	MP:0010771	15.0	CNR1, CNR2, KIFAP3, VGF, LMNB1, RAC1
12	hematopoietic system phenotype	MP:0005397	14.5	SH2D3C, CNTF, KIFAP3, BID, PAWR, BCL11B
13	vision/eye phenotype	MP:0005391	14.2	SELE, SEMA6A, VEGFA, LIF, BID, PANK2
14	no phenotypic analysis	MP:0003012	13.9	SH2D3C, CNR1, SERPINE2, VEGFA, BPTF, BDNF
15	reproductive system phenotype	MP:0005389	13.6	SH2D3C, VPS54, RBMS1, SERPINE2, SEMA6A, VGF
16	embryogenesis phenotype	MP:0005380	13.4	KIFAP3, VPS54, RBM3, SETD2, BPTF, LMNB1
17	skeleton phenotype	MP:0005390	13.3	CNR1, VEGFA, VDR, VCP, LIF, PARK2
18	digestive/alimentary phenotype	MP:0005381	13.3	VEGFA, VDR, LIF, KEAP1, BDNF, BCL2
19	renal/urinary system phenotype	MP:0005367	12.9	UTRN, BCL2, CHRNA3, CHGA, BAX, MT2A
20	respiratory system phenotype	MP:0005388	12.5	KIFAP3, SELL, LPL, UTRN, LIF, BID
21	liver/biliary system phenotype	MP:0005370	12.3	KIFAP3, VPS54, VEGFA, LPL, UTRN, LIF
22	limbs/digits/tail phenotype	MP:0005371	12.2	VEGFA, VDR, RAC1, UTRN, CHKB, BAX
23	tumorigenesis	MP:0002006	12.1	SELL, SERPINE1, BCL11B, BCL2, BCL2L1, BAD
24	adipose tissue phenotype	MP:0005375	12.0	CNR1, SERPINE1, VGF, LPL, LIF, BCL2
25	hearing/vestibular/ear phenotype	MP:0005377	11.9	VDR, BDNF, BCL2, SCN8A, BAX, P2RX7
26	endocrine/exocrine gland phenotype	MP:0005379	11.9	VPS54, SELL, SERPINE2, VGF, PANK2, UNC13A
27	other phenotype	MP:0005395	11.3	CNR1, KDR, LDLR, LAMC1, ITGB3, GSK3A
28	craniofacial phenotype	MP:0005382	11.1	VPS54, LMNB1, BDNF, BCL11B, FOXO1, FIG4

Articles related to lateral sclerosis:

(show top 50)    (show all 935)

id	Title	Authors	Year	Affiliating Genes
1	TP53 Arg72Pro polymorphism in Turkish patients with s poradic amyotrophic lateral sclerosis. (21741128)	Ergul E.... Idrisoglu H.A.	2011	TP53
2	EMMPRIN levels in serum of patients with amyotrophic lateral sclerosis. (21554254)	IA8A1ecka J.	2011	BSG
3	FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FU S mutations. (21856723)	Neumann M.... Mackenzie I.R.	2011	FUS, EWSR1, TAF15
4	PGC-1I+ protects neurons and alters disease progressio n in an amyotrophic lateral sclerosis mouse model. (22102466)	Liang H.... Van Remmen H.	2011	PPARGC1A
5	The role of autophagy: what can be learned from the g enetic forms of amyotrophic lateral sclerosis. (20406184)	Pasquali L.... Fornai F.	2010	TARDBP
6	Structural requirements for VAP-B oligomerization and their implication in amyotrophic lateral sclerosis-associated VAP-B(P56S) neur otoxicity. (20207736)	Kim S.... Lev S.	2010	VAPB
7	Association between novel TARDBP mutations and Chines e patients with amyotrophic lateral sclerosis. (20082726)	Xiong H.L.... Wu Z.Y.	2010	TARDBP
8	Ubiquilin modifies TDP-43 toxicity in a Drosophila mo del of amyotrophic lateral sclerosis (ALS). (20154090)	Hanson K.A.... Tibbetts R.S.	2010	TARDBP, UBQLN1
9	CSF hypocretin-1 levels are normal in patients with a myotrophic lateral sclerosis. (19922146)	Van Rooij F.G.... Overeem S.	2009	HCRT
10	Increased levels of inflammatory chemokines in amyotrophic lateral sclerosis. (19236470)	Kuhle J.... Czaplinski A.	2009	IL8, CCL2, CCL11
11	Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis. (19251627)	Kwiatkowski T.J. Jr.... Brown R.H. Jr.	2009	FUS
12	Lack of evidence of monomer/misfolded superoxide dism utase-1 in sporadic amyotrophic lateral sclerosis. (19670443)	Liu H.N.... Robertson J.	2009	SOD1
13	Tau phosphorylation at threonine-175 leads to fibril formation and enhanced cell death: implications for amyotrophic lateral sclerosis with cognitive impairment. (19046355)	Gohar M.... Strong M.J.	2009	MAPT
14	TDP-43 is consistently co-localized with ubiquitinate d inclusions in sporadic and Guam amyotrophic lateral sclerosis but not in fami lial amyotrophic lateral sclerosis with and without SOD1 mutations. (19496940)	Maekawa S.... Al-Sarraj S.	2009	SOD1, SQSTM1
15	Thioredoxin reductase 1 haplotypes modify familial amyotrophic lateral sclerosis onset. (18996185)	Mitchell J.... de Belleroche J.	2009	TXNRD1
16	A strategy for developing effective amyotropic lateral sclerosis pharmacotherapy: from clinical trials to novel pharmacotherapeutic strategies. (18627324)	Yamamoto M.... Sobue G.	2008	SOD1
17	Enrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosis. (18535185)	Igaz L.M.... Lee V.M.	2008	TARDBP
18	Progranulin mutations and amyotrophic lateral sclerosis or amyotrophic lateral sclerosis-frontotemporal dementia phenotypes. (17371905)	Schymick J.C.... Traynor B.J.	2007	GRN, RPS27A
19	Variations in the coding and regulatory sequences of the angiogenin (ANG) gene are not associated to ALS (amyotrophic lateral sclerosis) in the Italian population. (17462671)	Corrado L.... D'Alfonso S.	2007	ANG
20	Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations. (17469116)	Mackenzie I.R.... Trojanowski J.Q.	2007	SOD1, RPS27A, LOC643387
21	TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. (17084815)	Arai T.... Oda T.	2006	MAPT, TARDBP
22	Ascending neuropathology in the CNS of a mutant SOD1 mouse model of amyotrophic lateral sclerosis. (16737688)	Leichsenring A.... Stichel C.C.	2006	SOD1
23	Increased incidence of FMO1 gene single nucleotide polymorphisms in sporadic amyotrophic lateral sclerosis. (17127561)	Cereda C.... Ceroni M.	2006	FMO1
24	Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking. (17093100)	Lai C.... Cai H.	2006	GRIA2, ALS2, GRIP1
25	Complement C3c and related protein biomarkers in amyotrophic lateral sclerosis and Parkinson's disease. (16516157)	Goldknopf I.L.... Appel S.H.	2006	C3
26	Structural properties and neuronal toxicity of amyotrophic lateral sclerosis-associated Cu/Zn superoxide dismutase 1 aggregates. (16216923)	Matsumoto G.... Morimoto R.I.	2005	SOD1
27	Galectin-1 as a potential therapeutic agent for amyotrophic lateral sclerosis. (16026259)	Kato T.... Kawanami T.	2005	LGALS1
28	Amyotrophic lateral sclerosis: recent insights from transgenic animal models with SOD1 mutations (15651292)	Aoki M.	2004	SOD1
29	A novel locus for late onset amyotrophic lateral sclerosis/motor neurone disease variant at 20q13. (15060112)	Nishimura A.L.... Zatz M.	2004	VAPB
30	Identification of two novel mutations in the Cu/Zn superoxide dismutase gene with familial amyotrophic lateral sclerosis: mass spectrometric and genomic analyses. (14759637)	Sato T.... Sakoda S.	2004	SOD1
31	Analysis of the cytosolic proteome in a cell culture model of familial amyotrophic lateral sclerosis reveals alterations to the proteasome, antioxidant defenses, and nitric oxide synthetic pathways. (12475980)	Allen S.... Shaw P.J.	2003	SOD1, ASL, RBM3
32	Familial amyotrophic lateral sclerosis-associated mutations decrease the thermal stability of distinctly metallated species of human copper/zinc superoxide dismutase. (11854285)	Rodriguez J.A.... Hayward L.J.	2002	SOD1
33	Flip and flop splice variants of AMPA receptor subunits in the spinal cord of amyotrophic lateral sclerosis. (12125045)	Tomiyama M.... Mengod G.	2002	GRIA3, GRIA2, GRIA1
34	D90A-SOD1 mediated amyotrophic lateral sclerosis: a single founder for all cases with evidence for a Cis-acting disease modifier in the recessive haplotype. (12442272)	Parton M.J.... Shaw C.E.	2002	SOD1
35	Association of APOE epsilon4 allele with survival in amyotrophic lateral sclerosis. (11574101)	Drory V.E.... Chapman J.	2001	APOE
36	Increased cystatin C immunoreactivity in the skin in amyotrophic lateral sclerosis. (10893063)	Ono S.... Nagao K.	2000	CST3
37	Increased expression of glial cell line-derived neurotrophic factor mRNA in muscle biopsies from patients with amyotrophic lateral sclerosis. (10202982)	GrundstrAPm E.... Aquilonius S.M.	1999	BDNF, GDNF
38	Cytotoxic activity of serum and cerebrospinal fluid of amyotrophic lateral sclerosis (ALS) patients against acetylcholinesterase. (10464429)	NIEBROJ-DOBOSZ I.... Mickielewicz A.	1999	ACHE
39	Chaperone-facilitated copper binding is a property common to several classes of familial amyotrophic lateral sclerosis-linked superoxide dismutase mutants. (9600970)	Corson L.B.... Cleveland D.W.	1998	SOD1
40	Immunohistochemical localization of brain-derived neurotrophic factor in the spinal cords of amyotrophic lateral sclerosis and non-amyotrophic lateral sclerosis patients. (9737545)	Kawamoto Y.... Kimura J.	1998	BDNF
41	Comparative study of ubiquitin immunoreactivity of hi ppocampal granular cells in amyotrophic lateral sclerosis with dementia, Guaman ian amyotrophic lateral sclerosis and Guamanian parkinsonism-dementia complex. (9083558)	Ikemoto A.... Kimura J.	1997	RPS27A
42	Amyotrophic lateral sclerosis: oxidative energy metab olism and calcium homeostasis in peripheral blood lymphocytes. (8857745)	Curti D.... Ceroni M.	1996	CAT
43	SOD1 mutation is associated with accumulation of neurofilaments in amyotrophic lateral sclerosis. (8572658)	Rouleau G.A.... Figlewicz D.	1996	SOD1
44	A placebo-controlled trial of recombinant human cilia ry neurotrophic (rhCNTF) factor in amyotrophic lateral sclerosis. rhCNTF ALS St udy Group. (8967757)	Miller R.G.... Stromatt S.C.	1996	CNTF
45	Concurrence of Alzheimer's disease, Parkinson's disea se, diffuse Lewy body disease, and amyotrophic lateral sclerosis. (7738598)	Hedera P.... Friedland R.P.	1995	RPS27A
46	Investigation of a null mutation of the CNTF gene in familial amyotrophic lateral sclerosis. (8543936)	Orrell R.W.... de Belleroche J.S.	1995	CNTF
47	Double blind cross over trial with deprenyl in amyotrophic lateral sclerosis. (7931231)	Jossan S.S.... Aquilonius S.M.	1994	MAOB
48	Familial amyotrophic lateral sclerosis (ALS) in Japan associated with H46R mutation in Cu/Zn superoxide dismutase gene: a possible new subtype of familial ALS. (7836951)	Aoki M.... Abe K.	1994	SOD1
49	Ubiquitin-positive inclusion in anterior horn cells in subgroups of motor neuron diseases: a comparative study of adult-onset amyotrophic lateral sclerosis, juvenile amyotrophic lateral sclerosis and Werdnig-Hoffmann disease. (8387100)	Matsumoto S.... Hirano A.	1993	RPS27A
50	Reductions in acidic amino acids and N-acetylaspartylglutamate in amyotrophic lateral sclerosis CNS. (1682006)	Tsai G.C.... Coyle J.T.	1991	FOLH1

Genes related to lateral sclerosis according to GeneCards:

(show top 50)    (show all 512)

id	Symbol	Description	Score	GeneCards Section Context
1	ALS2	amyotrophic lateral sclerosis 2 (juvenile)	11.1	Publications, Transcripts, Aliases & Descriptions, Pathways & Interactions (show all 6 sections) Orthologs, Summaries
2	SETX	senataxin	11.1	Publications, Aliases & Descriptions, Orthologs, Summaries
3	SOD1	superoxide dismutase 1, soluble	11.1	Publications, Aliases & Descriptions, Pathways & Interactions, Orthologs (show all 5 sections) Summaries
4	FUS	fused in sarcoma	11.1	Publications, Aliases & Descriptions, Summaries
5	ICA1L	islet cell autoantigen 1,69kDa-like	11.1	Publications, Aliases & Descriptions
6	RAPH1	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	11.1	Publications, Aliases & Descriptions
7	NBEAL1	neurobeachin-like 1	11.1	Publications, Aliases & Descriptions
8	NEFH	neurofilament, heavy polypeptide	11.1	Publications, Functions, Pathways & Interactions, Summaries
9	PRPH	peripherin	11.1	Publications, Pathways & Interactions, Summaries
10	TRPM7	transient receptor potential cation channel, subfamily M, member 7	11.1	Publications, Summaries
11	NIF3L1	NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae)	11.1	Publications, Aliases & Descriptions
12	STRADB	STE20-related kinase adaptor beta	11.1	Publications, Aliases & Descriptions, Orthologs
13	TRAK2	trafficking protein, kinesin binding 2	11.1	Publications, Aliases & Descriptions
14	GRIA2	glutamate receptor, ionotropic, AMPA 2	11.1	Publications, Pathways & Interactions, Summaries
15	SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	11.1	Publications, Pathways & Interactions, Summaries
16	TMEM237	transmembrane protein 237	11.1	Publications, Aliases & Descriptions, Orthologs
17	ALS2CR8	amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 8	11.1	Transcripts, Publications, Aliases & Descriptions, Proteins (show all 5 sections) Orthologs
18	CDK15	cyclin-dependent kinase 15	11.1	Publications, Aliases & Descriptions
19	FAM117B	family with sequence similarity 117, member B	11.1	Publications, Aliases & Descriptions
20	PARD3B	par-3 partitioning defective 3 homolog B (C. elegans)	11.1	Publications, Aliases & Descriptions
21	C9orf72	chromosome 9 open reading frame 72	11.1	Publications, Summaries
22	AOX1	aldehyde oxidase 1	11.1	Publications, Summaries
23	YWHAQ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	11.1	Publications, Expressions, Summaries
24	FGGY	FGGY carbohydrate kinase domain containing	11.1	Publications, Summaries
25	ALS5	amyotrophic lateral sclerosis 5	11.1	Publications, Aliases & Descriptions
26	TAF15	TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa	11.1	Publications, Summaries
27	UNC13A	unc-13 homolog A (C. elegans)	11.1	Publications, Summaries
28	S100B	S100 calcium binding protein B	11.1	Publications, Summaries
29	PLSA1	Primary lateral sclerosis, adult, 1	11.1	Aliases & Descriptions
30	ALS3	amyotrophic lateral sclerosis 3 (autosomal dominant)	11.1	Publications, Aliases & Descriptions
31	ALS7	amyotrophic lateral sclerosis 7	11.1	Publications, Aliases & Descriptions
32	LOC644462	amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2 pseudogene	11.1	Aliases & Descriptions, Publications
33	CFLAR-AS1	CFLAR antisense RNA 1	11.1	Aliases & Descriptions, Publications
34	ALS2CR12	amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 12	11.1	Publications, Aliases & Descriptions, Orthologs
35	ALS2CR11	amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11	11.1	Transcripts, Publications, Aliases & Descriptions, Proteins (show all 5 sections) Orthologs
36	MPP4	membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)	11.1	Publications, Aliases & Descriptions
37	TARDBP	TAR DNA binding protein	11.0	Publications
38	DCTN1	dynactin 1	11.0	Publications
39	ARHGEF28	Rho guanine nucleotide exchange factor (GEF) 28	11.0	Summaries
40	ANG	angiogenin, ribonuclease, RNase A family, 5	11.0	Publications
41	VAPB	VAMP (vesicle-associated membrane protein)-associated protein B and C	11.0	Publications, Orthologs
42	CCS	copper chaperone for superoxide dismutase	11.0	Publications, Pathways & Interactions
43	NEFL	neurofilament, light polypeptide	11.0	Publications, Pathways & Interactions
44	CNTF	ciliary neurotrophic factor	11.0	Publications, Functions
45	CHMP2B	charged multivesicular body protein 2B	11.0	Publications
46	GRN	granulin	11.0	Publications
47	PRPH2	peripherin 2 (retinal degeneration, slow)	11.0	Publications, Pathways & Interactions
48	PVALB	parvalbumin	11.0	Publications
49	RPS27A	ribosomal protein S27a	11.0	Publications
50	CDK5	cyclin-dependent kinase 5	11.0	Publications, UniProt Related

Pathways related to lateral sclerosis according to GeneDecks:

(show top 50)    (show all 227)

id	Pathway	Score	Top Affiliating Genes
1	Amyotrophic lateral sclerosis (ALS)20	15.9	RAB5A, RAC1, BID, BCL2, BCL2L1, CHP2
2	Neuroscience3	14.4	PARK7, PARK2, S100B, ATXN1, CDK5, CDK5R1
3	p38 Signaling36	14.3	RAC1, LIF, BDNF, KDR, BCL2, BAX
4	Cellular Apoptosis Pathway36	13.8	VDAC2, BID, PAWR, BDNF, KDR, BCL2
5	DHA Signaling36	13.7	BID, BDNF, KDR, BCL2, BCL2L1, YWHAQ
6	Molecular Mechanisms of Cancer36	13.7	LIF, BID, BDNF, KDR, BCL2, BCL2L1
7	MAPK Family Pathway36	13.4	RAC1, BDNF, KDR, BCL2, BAX, JUN
8	PAK Pathway36	13.3	RAC1, LIF, BDNF, KDR, BCL2, BAX
9	Alzheimers disease20	13.2	LPL, BID, CHP2, CHP1, BAD, CDK5
10	Antioxidant Action of Vitamin-C36	13.2	RAC1, LIF, BDNF, KDR, BCL2, BAX
11	Mitochondrial Apoptosis36	13.2	VDAC2, BID, BDNF, KDR, BCL2, BCL2L1
12	MAPK Signaling36	13.1	RAC1, BDNF, KDR, BCL2, LAMC1, ATF3
13	14-3-3 Induced Apoptosis36	13.1	BID, BCL2, YWHAQ, BAD, JUN, FOS
14	Intracellular Calcium Signaling36	13.0	BDNF, KDR, CHRNA3, CHRNA4, P2RX7, ITPR2
15	STAT3 Pathway36	13.0	RAC1, LIF, BCL2, BAX, MET, IL15
16	p53 Mediated Apoptosis36	13.0	BID, BDNF, KDR, BCL2, BAX, FGF1
17	Pathogenesis of ALS36	12.9	BCL2, BCL2L1, BAD, BAX, GRIA1, GRIA2
18	TGF-Beta Pathway36	12.9	BDNF, KDR, BCL2, BAX, JUN, FOS
19	Apoptosis and Autophagy3	12.9	LMNB1, BID, PAWR, BCL2, BCL2L1, LGALS1
20	PEDF Induced Signaling36	12.8	LIF, BDNF, BCL2, BCL2L1, BAX, CFLAR
21	Neurotrophin signaling pathway20	12.8	RAC1, BDNF, BCL2, YWHAQ, BAD, BAX
22	MAPK signaling pathway20	12.7	RAC1, BDNF, CHP2, CHP1, JUN, FOS
23	Apoptosis Signaling Pathways37	12.7	NAIP, BID, BCL2, BCL2L1, YWHAQ, BAD
24	Tec Kinases Signaling36	12.7	RAC1, BDNF, BCL2, BAX, ITGA2, ITGB3
25	PPAR Pathway36	12.6	ITGA2, ITGB3, FGF1, FGF2, FGFR1, MET
26	Rho Family GTPases36	12.6	RAC1, LIF, BDNF, KDR, BCL2, BAX
27	Akt Signaling36	12.5	LIF, ITGA2, FOXO1, GSK3A, FGF1, FGFR1
28	TNF-Induced Apoptosis Implicating Sphingolipids36	12.5	BAD, BAX, MAPK8, MAP2K6, MAP2K3, MAPK12
29	Apoptosis20	12.5	BID, BCL2, BCL2L1, CHP2, CHP1, BAD
30	Pathways in cancer20	12.4	VEGFA, RAC1, BCL2, BCL2L1, BAD, BAX
31	JAK-STAT Pathway36	12.4	BDNF, KDR, UBC, BAX, JUN, FOS
32	NFAT in Immune Response36	12.4	BDNF, KDR, JUN, CD79A, ITPR2, FOS
33	Glucocorticoid Receptor Signaling36	12.4	BCL2, BAX, JUN, FOS, GRIP1, IL15
34	CREB Pathway36	12.4	BDNF, KDR, ITPR2, FGF1, FGFR1, GRIA1
35	TNF Signaling36	12.2	BID, ATF3, JUN, FOS, APAF1, MAPK8
36	TNF Superfamily Pathway36	12.2	JUN, FOS, MAPK8, MAP2K6, MAP2K3, MAPK12
37	Toxoplasmosis20	12.2	BCL2, BCL2L1, LDLR, BAD, LAMC1, MAPK8
38	Tuberculosis20	12.1	VDR, RAB5A, BID, BCL2, CHP2, CHP1
39	14-3-3 Induced Intracellular Signaling36	12.1	BDNF, YWHAQ, BAD, JUN, FGF1, FGF2
40	p53 Signaling36	12.1	BCL2, UBC, BAX, CDK4, FOS, MAPK8
41	Apoptosis and survival FAS signaling cascades10	12.0	LMNB1, BID, BCL2, BAX, CFLAR, APAF1
42	Apoptosis and survival_FAS signaling cascades41	12.0	LMNB1, BID, BCL2, BAX, CFLAR, APAF1
43	Glutamic acid signaling10	12.0	GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIN1
44	Glutamatergic synapse20	11.9	CHP2, CHP1, ITPR2, GRIA1, GRIA2, GRIA3
45	Renin-Angiotensin Pathway36	11.7	RAC1, BDNF, KDR, JUN, ITPR2, FOS
46	Development_VEGF signaling via VEGFR2 - generic cascades41	11.7	VEGFA, RAC1, JUN, ITGB3, ITPR2, FOS
47	Endothelin-1 Signaling Pathway36	11.6	CASP3, CASP1, NTRK1, NTRK2, NOS1, CSF1
48	VEGF signaling pathway20	11.6	VEGFA, RAC1, KDR, CHP2, CHP1, BAD
49	Chagas disease (American trypanosomiasis)20	11.3	SERPINE1, CFLAR, JUN, FOS, IL8, FASLG
50	Neuroactive ligand-receptor interaction20	11.0	CNR1, CNR2, CHRNA3, CHRNA4, P2RX7, GZMA

Compounds related to lateral sclerosis according to GeneDecks:

(show top 50)    (show all 532)

id	Compound	Score	Top Affiliating Genes
1	calcium32 9 18 9	22.7	CNR1, CNTF, BTBD10, SERPINE2, NAIP, LPA
2	oxygen32 18	18.9	SETD2, RAC1, LIF, LIPC, BLVRB, BID
3	cysteine32	17.8	NAIP, LPA, VDR, LMNB1, RAB5A, RAC1
4	atp32	17.0	RFK, SETD2, VDAC2, VCP, RAC1, LIF
5	nmda32 42	16.8	CNR1, BLVRB, PARK2, BDNF, BCL2L1, CHAT
6	arginine32	15.6	CNR1, CNR2, CNTF, LPA, VDR, RAC1
7	nitric oxide32 9 18 9	18.1	CNTF, SELE, LPA, UTRN, LIF, BLVRB
8	creatinine32	14.7	SELE, SELL, VDR, UTRN, PABPN1, BDNF
9	doxorubicin32 34 9 9	17.5	SELE, SETD2, BID, BDNF, KDR, BCL2L1
10	choline32 9 18 9	17.4	CNTF, LIF, BLVRB, BDNF, CHAT, CHKB
11	adp32 18	15.3	RFK, LPA, VCP, RAC1, PANK2, KDR
12	hydrogen32 18	15.1	CNR2, RAC1, KEAP1, BDNF, CHGA, CHKB
13	leucine32	14.0	LPA, RAC1, PAWR, PARK2, KEAP1, CHKB
14	adenylate32	13.7	CNR1, CNR2, CNTF, SELE, SERPINE1, LPL
15	actinomycin d32	13.5	CNTF, SELE, SERPINE2, SETD2, SERPINE1, VEGFA
16	histamine32 18	13.8	CNR1, CNTF, SELE, SELL, BDNF, SCG2
17	lactacystin32	12.6	SELE, VDR, PARK2, BCL2, BCL2L1, P4HB
18	rotenone32	12.6	PARK7, PARK2, BCL2, BCL2L1, BAD, XDH
19	4-hydroxynonenal32 18	13.6	CHAT, UCP3, BAX, XDH, JUN, FOS
20	pyruvate32	12.6	SETD2, CKM, CHAT, CHKB, UCP3, P4HB
21	cyclosporin a32 42	13.5	BSG, LPL, VDR, LIF, LIPC, BID
22	methamphetamine32 9 9	14.4	CNTF, BDNF, CHAT, MMP2, MB, MAP2
23	n acetylcysteine32	12.3	SELE, SETD2, BDNF, KDR, CD79A, CDK5
24	lysine32	12.2	PARK7, PARK2, CHKB, LDLR, S100A6, ISG15
25	mannitol32 9 9	14.2	CHKB, S100B, XDH, B2M, FGF2, AQP4
26	3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide32	12.1	BCL2, BCL2L1, BAX, S100B, MMP2, MMP9
27	citrate32	12.1	VDR, CHGA, CHKB, UCP3, P4HB, CD79A
28	anisomycin32 42 9 9	15.1	BDNF, KCNA2, LDLR, CFLAR, ATF3, JUN
29	lovastatin32 42 9 9	15.0	LPA, LPL, RAB5A, RAC1, LIPC, CHKB
30	geldanamycin32 9 9	13.9	SETD2, VEGFA, PARK2, KDR, BCL2L1, CFLAR
31	sodium dodecylsulfate32	11.8	SERPINE1, LPA, LPL, LIPC, CETP, CD79A
32	urea32 9 18 9	14.8	LPA, CHKB, P4HB, B2M, ASL, AQP4
33	agarose32	11.8	LPA, LIF, BCL2, BCL2L1, LGALS1, CHKB
34	carboplatin32 34 9 9	14.7	VEGFA, LIF, BID, KDR, BCL2, CHGA
35	vitamin b1232	11.7	LPA, MTHFR, B2M, CD79A, FOLH1, APOB
36	suberoylanilide hydroxamic acid32	11.6	BID, BCL2, BCL2L1, BAX, CFLAR, FGFR1
37	polyethylene glycol32	11.6	SELE, CHKB, P4HB, APOE, MB, NTS
38	diphenyleneiodonium32	11.6	SETD2, VEGFA, RAC1, XDH, JUN, IL8
39	endotoxin32	11.6	SELL, LIF, BLVRB, CHKB, MT3, IL1RAPL2
40	chloramphenicol32 9 9	13.4	SELE, SETD2, SERPINE1, LPL, VDR, CKM
41	sulindac sulfide32	11.4	BCL2, BCL2L1, BAX, ATF3, JUN, APP
42	aspirin32 34 18	13.4	CNR1, SELE, SELL, SERPINE1, LPA, VDR
43	tacrolimus32 34 9 9	14.4	SERPINE1, VDR, CHKB, BAD, CD79A, CDK4
44	herbimycin a32 42	12.4	SELE, SELL, JUN, CDK4, MMP2, MMP9
45	calcitriol32 42 9 18 9	15.2	VDR, LIF, B2M, JUN, CDK5, CDK4
46	adenine32 9 18 9	14.0	SETD2, LDLR, MTHFR, S100B, XDH, MMP3
47	triptolide32	10.9	VEGFA, BCL2, BAX, JUN, MMP3, IL8
48	apocynin32	10.7	SELE, SETD2, RAC1, XDH, JUN, MAPK8
49	vitamin d32	10.7	SERPINE1, LPL, VDR, CHGA, CHKB, LDLR
50	rantes32	10.3	SELE, SELL, RAC1, LIF, SCG2, JUN

Cellular components related to lateral sclerosis according to GeneDecks:

(show all 22)

id	Name	GO ID	Score	Top Affiliating Genes
1	cytoplasm	GO:005737	19.5	ZNF746, SH2D3C, RFK, RCC1, BTBD10, RBM3
2	nucleus	GO:005634	16.8	ZNF512B, ZNF746, CNTF, RCC1, BTBD10, RBM3
3	plasma membrane	GO:005886	16.6	CNR1, CNR2, CNTFR, CNTN4, CNTN6, SELE
4	cytosol	GO:005829	15.6	RFK, CNTF, KIFAP3, SERPINE2, VDR, VCP
5	mitochondrion	GO:005739	14.8	RFK, RDH14, BSG, VDAC2, BID, PARK7
6	extracellular space	GO:005615	13.4	CNTF, PCSK1N, SELE, SERPINE1, VGF, VEGFA
7	extracellular region	GO:005576	13.2	CNTN4, SERPINE2, SERPINE1, VEGFA, LPA, LPL
8	axon	GO:030424	12.8	CNTF, CNTN4, SEMA6A, PARK7, CHAT, ATP1A3
9	neuronal cell body	GO:043025	12.7	CNTF, SERPINE2, VGF, CHRNA3, CHAT, CHRNA4
10	cell surface	GO:009986	12.6	VEGFA, LPL, LGALS1, LDLR, P4HB, ITGA2
11	integral to plasma membrane	GO:005887	12.5	CNR1, CNR2, SELL, SEMA6A, KDR, LDLR
12	nucleoplasm	GO:005654	12.4	RCC1, SETX, VDR, LMNB1, PABPN1, UBC
13	perinuclear region of cytoplasm	GO:048471	12.3	SELE, VAPA, PARK2, UBQLN1, MT1E, MT2A
14	postsynaptic density	GO:014069	11.9	CHRNA3, CDK5, CDK5R1, MET, GRIA1, GRIA2
15	protein complex	GO:043234	11.8	UTRN, UBQLN1, MMP9, ANXA6, HTT, ALB
16	cell junction	GO:030054	11.6	UTRN, UNC13A, CHRNA3, CHRNA4, ATN1, CDK5
17	growth cone	GO:030426	11.5	CDK5, CDK5R1, GRIA2, ANG, MAPT, IGHMBP2
18	postsynaptic membrane	GO:045211	11.3	UTRN, CHRNA3, CHRNA4, CDK5, MET, GRIA1
19	terminal button	GO:043195	11.1	P2RX7, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A
20	membrane raft	GO:045121	11.1	SELE, BSG, RAB5A, P2RX7, CD79A, CASP8
21	melanosome	GO:042470	10.8	BSG, RAB5A, RAC1, P4HB, ITGB3, ANXA6
22	external side of plasma membrane	GO:009897	10.7	SELL, KDR, SCNN1A, CHRNA4, LDLR, P2RX7

Biological processes related to lateral sclerosis according to GeneDecks:

(show top 50)    (show all 64)

id	Name	GO ID	Score	Top Affiliating Genes
1	apoptotic process	GO:006915	14.5	SEMA6A, LMNB1, RAC1, BID, PAWR, BCL2
2	small molecule metabolic process	GO:044281	14.2	RFK, BSG, LPA, LPL, VAPA, VAPB
3	cell death	GO:008219	13.5	SETX, VAPA, VAPB, PARK7, PARK2, PANK2
4	anti-apoptosis	GO:006916	13.4	NAIP, BDNF, BCL2, BCL2L1, UBC, CFLAR
5	signal transduction	GO:007165	13.2	CNTF, CNTFR, KIFAP3, VDR, VAPA, RAPH1
6	response to drug	GO:042493	13.0	LPL, PARK7, BDNF, BCL2, LGALS1, CHRNA3
7	negative regulation of neuron apoptotic process	GO:043524	12.7	CNTF, CNTFR, NAIP, PARK7, PARK2, BDNF
8	nerve growth factor receptor signaling pathway	GO:048011	12.5	RAC1, UBC, BAD, ITPR2, FOXO1, ARHGEF2
9	nervous system development	GO:007399	12.5	CNTFR, CNTN4, SEMA6A, NAIP, VEGFA, RAB5A
10	synaptic transmission	GO:007268	12.5	KCNA2, CHRNA3, CHAT, CHRNA4, ATXN3, CDK5
11	positive regulation of transcription from RNA polymerase II promoter	GO:045944	12.3	SERPINE1, VEGFA, VDR, LIF, BCL11B, CHP2
12	positive regulation of apoptotic process	GO:043065	12.2	CNR1, BID, PAWR, BAD, BAX, P2RX7
13	response to hypoxia	GO:001666	12.2	VEGFA, BCL2, CHAT, CHRNA4, UCP3, UBQLN1
14	induction of apoptosis by extracellular signals	GO:008624	12.2	VDR, RAC1, UBC, BAD, BAX, CFLAR
15	inflammatory response	GO:006954	12.2	CNR2, SELE, RAC1, PARK7, SCG2, P2RX7
16	negative regulation of apoptotic process	GO:043066	12.1	SERPINE1, VEGFA, KDR, BCL11B, BCL2, BCL2L1
17	induction of apoptosis by intracellular signals	GO:008629	12.1	BID, BCL2, BCL2L1, BAD, BAX, GZMB
18	blood coagulation	GO:007596	12.1	KIFAP3, SELL, SERPINE2, SERPINE1, BSG, VEGFA
19	innate immune response	GO:045087	12.0	BCL2, BCL2L1, UBC, S100B, P2RX7, JUN
20	positive regulation of cell proliferation	GO:008284	12.0	CNTF, CNTFR, VEGFA, LIF, KDR, BCL2L1
21	memory	GO:007613	11.8	CNR1, CHAT, S100B, ATP1A3, GRIN2A, HTR2A
22	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	11.8	VCP, BAD, BAX, XDH, APAF1, FASLG
23	response to wounding	GO:009611	11.8	RAC1, MET, GRIN2A, GRIN2C, F2, CASP3
24	induction of apoptosis	GO:006917	11.7	PAWR, BAD, BAX, APOE, FASLG, IFNB1
25	neuron apoptotic process	GO:051402	11.7	BID, BCL2, BAX, ATN1, CDK5, APP
26	adult locomotory behavior	GO:008344	11.7	PARK7, ATP1A3, GRIN1, GRIN2D, APP, NTF4
27	aging	GO:007568	11.6	CNR1, VDR, UCP3, JUN, IL15, CCL2
28	activation of MAPK activity	GO:000187	11.6	UBC, P2RX7, FGF2, MET, GRM1, GRM4
29	response to lipopolysaccharide	GO:032496	11.6	CNR1, CNR2, SELE, P2RX7, JUN, MMP9
30	angiogenesis	GO:001525	11.6	SETD2, SERPINE1, VEGFA, KDR, SCG2, JUN
31	activation of pro-apoptotic gene products	GO:008633	11.6	BID, BCL2, BAD, BAX, CDK5, GZMB
32	release of cytochrome c from mitochondria	GO:001836	11.5	BID, BCL2, BCL2L1, BAX, JUN, GPX1
33	response to ethanol	GO:045471	11.4	CNR1, BCL2, CHAT, MMP9, GRIN1, GRIN2A
34	response to amphetamine	GO:001975	11.4	CNR2, GRIN1, GRIN2A, GRIN2B, ICAM1, DRD2
35	positive regulation of MAPK cascade	GO:043410	11.2	CNTF, LIF, KDR, P2RX7, FGFR1, GRM4
36	response to mechanical stimulus	GO:009612	11.2	P2RX7, JUN, MMP9, ANGPT2, CCL2, IGFBP2
37	positive regulation of angiogenesis	GO:045766	11.2	SERPINE1, VEGFA, KDR, MMP9, FGF1, FGF2
38	stress-activated MAPK cascade	GO:051403	11.1	UBC, JUN, FOS, MAPK8, MAP2K6, MAP2K3
39	response to heat	GO:009408	11.1	BCL2, MMP9, CCL2, HSF1, HSPA4, CALCA
40	regulation of excitatory postsynaptic membrane potential	GO:060079	11.0	CHRNA3, CDK5, GRIN1, GRIN2A, GRIN2B, GRIN2C
41	response to cold	GO:009409	11.0	PCSK1N, RBM3, VGF, UCP3, CASP8, TRH
42	embryo implantation	GO:007566	10.9	SERPINE2, BSG, LIF, MMP9, GRN, CALCA
43	cellular response to organic substance	GO:071310	10.9	BCL2, BAX, MAP2, CALB1, CASP3, CASP1
44	positive regulation of endothelial cell proliferation	GO:001938	10.9	VEGFA, KDR, SCG2, JUN, CDH13, ITGB3
45	locomotory behavior	GO:007626	10.9	CHRNA3, CHRNA4, GRM1, FEZF2, APP, HTT
46	lipoprotein metabolic process	GO:042157	10.8	LPA, LPL, LDLR, P4HB, CETP, APOA4
47	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	10.8	VAPA, PARK2, LGALS1, UBC, S100B, CFLAR
48	sensory perception of pain	GO:019233	10.7	CNR1, CNR2, CHRNA4, P2RX7, CDK5, GRIN1
49	response to organic cyclic compound	GO:014070	10.6	P2RX7, JUN, MET, ENO2, ANGPT2, F7
50	positive regulation of protein phosphorylation	GO:001934	10.5	VEGFA, MT3, ITGB3, FGF1, ENG, F2

Molecular functions related to lateral sclerosis according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	20.7	SOX5, TGM2, TH, TIMP3, TLR4, TLR2
2	protein homodimerization activity	GO:042803	12.8	GDNF, SMAD3, NTRK2, NTRK1, SRR, DAXX
3	identical protein binding	GO:042802	12.4	SNCA, TNF, TP53, AKT1, GLUL, SYP
4	growth factor activity	GO:008083	12.2	NTF4, NRTN, NGF, AGT, NUDT6, CSF1
5	receptor binding	GO:005102	12.0	NRTN, NTF3, DAO, TRAK2, GLG1, CALCA
6	copper ion binding	GO:005507	12.0	ALB, TP53, SNCA, PRNP, SOD1, SLC11A2
7	enzyme binding	GO:019899	11.7	DAXX, CYP1A2, PPP3CA, PPP3CB, PPARG, HIF1A
8	extracellular-glutamate-gated ion channel activity	GO:005234	11.5	GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN1, GRIK1
9	heparin binding	GO:008201	11.1	FGFR1, APOB, APOE, APP, ANG, CCL2
10	calmodulin binding	GO:005516	11.1	NOS1, NOS2, NOS3, RRAD, EEA1, ADD1
11	drug binding	GO:008144	11.0	PPP3CA, PPP3CB, PPARG, SLC6A3, SIGMAR1, ADRB2
12	cadmium ion binding	GO:046870	10.9	SLC11A2, NOS3, NOS1, MT1B, MT3, MT1E
13	glutamate receptor activity	GO:008066	10.9	GRM5, GRM4, GRM3, GRM2, GRM1, GRIA2
14	NADP binding	GO:050661	10.7	G6PD, H6PD, NOS3, NOS2, NOS1, TXNRD1