MCID: LTT001
MIFTS: 34

Lattice Corneal Dystrophy malady

Genetic diseases, Eye diseases, Neuronal diseases, Rare diseases categories

Aliases & Classifications for Lattice Corneal Dystrophy

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Sources:
10Disease Ontology, 47Novoseek, 12DISEASES, 65UMLS, 36MeSH, 59SNOMED-CT
See all sources

Aliases & Descriptions for Lattice Corneal Dystrophy:

Name: Lattice Corneal Dystrophy 10 47 12
Familial Amyloid Neuropathy, Finnish Type 10
 
Familial Amyloid Polyneuropathy, Type V 65


Classifications:



External Ids:

Disease Ontology10 DOID:8943
MeSH36 C537935

Summaries for Lattice Corneal Dystrophy

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Wikipedia:68 Lattice corneal dystrophy type, also known as Biber-Haab-Dimmer dystrophy, is a rare form of corneal... more...

MalaCards based summary: Lattice Corneal Dystrophy, also known as familial amyloid neuropathy, finnish type, is related to corneal dystrophy and corneal dystrophy, avellino type. An important gene associated with Lattice Corneal Dystrophy is TGFBI (Transforming Growth Factor, Beta-Induced, 68kDa), and among its related pathways are Coregulation of Androgen receptor activity and Senescence and Autophagy. Affiliated tissues include eye and kidney, and related mouse phenotypes are cellular and homeostasis/metabolism.

Related Diseases for Lattice Corneal Dystrophy

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Diseases in the Lattice Corneal Dystrophy family:

Corneal Dystrophy, Lattice Type I Corneal Dystrophy, Lattice Type Iiia
Lattice Corneal Dystrophy Type Ii

Diseases related to Lattice Corneal Dystrophy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)
idRelated DiseaseScoreTop Affiliating Genes
1corneal dystrophy32.0GSN, TGFBI
2corneal dystrophy, avellino type31.1TGFBI, TGIF1
3corneal dystrophy, lattice type i31.0GSN, TGFBI, TGIF1
4corneal dystrophy, gelatinous drop-like30.7GSN, TACSTD2, TGFBI
5lattice corneal dystrophy type ii11.0
6amyloidosis10.8
7corneal dystrophy, lattice type iiia10.7
8amyloidosis, finnish type10.6
9familial amyloidosis, finnish type10.5
10polyneuropathy10.4
11amyloidosis, primary localized cutaneous, 110.3
12cataract10.3
13juvenile glaucoma10.3
14choroiditis10.3
15recurrent corneal erosion10.3
16polycystic kidney disease10.3
17autonomic neuropathy10.3
18corneal degeneration10.3
19kidney disease10.3
20neuropathy10.3
21polyneuropathy in collagen vascular disease10.1TBCD, TGFBI
22melanoacanthoma10.1TGFB1, TGFBI
23immunodeficiency 28, mycobacteriosis10.0TGFB1, TGFBI
24vulva adenocarcinoma10.0TGFB1, TGFBI
25factitious disorder10.0GSN, TGFB1
26tertiary neurosyphilis10.0TGFB1, TGFBI
27urethra adenocarcinoma10.0TGFB1, TGFBI
28hyperinsulinism-hyperammonemia syndrome10.0TGFB1, TGFBI
29anal canal adenocarcinoma10.0GSN, TGFBI
30urinary tract papillary transitional cell benign neoplasm10.0TGFB1, TGFBI
31otosclerosis 410.0GSN, TACSTD2
32buschke-ollendorff syndrome10.0TGFB1, TGFBI
33fuchs' endothelial dystrophy9.9GSN, TACSTD2, TGFBI
34hypoinsulinemic hypoglycemia with hemihypertrophy9.9TGFB1, TGIF1
35corneal edema9.9TACSTD2, TGFBI
36hereditary spastic paraplegia9.7TGFB1, TGIF1
37bronchus mucoepidermoid carcinoma9.1GSN, TACSTD2, TBCD, TGFB1, TGFBI, TGIF1

Graphical network of the top 20 diseases related to Lattice Corneal Dystrophy:



Diseases related to lattice corneal dystrophy

Symptoms for Lattice Corneal Dystrophy

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Drugs & Therapeutics for Lattice Corneal Dystrophy

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Lattice Corneal Dystrophy

Genetic Tests for Lattice Corneal Dystrophy

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Anatomical Context for Lattice Corneal Dystrophy

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MalaCards organs/tissues related to Lattice Corneal Dystrophy:

33
Eye, Kidney

Animal Models for Lattice Corneal Dystrophy or affiliated genes

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MGI Mouse Phenotypes related to Lattice Corneal Dystrophy:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053847.6GSN, TACSTD2, TGFB1, TGFBI, TGIF1
2MP:00053767.6GSN, TACSTD2, TGFB1, TGFBI, TGIF1

Publications for Lattice Corneal Dystrophy

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Articles related to Lattice Corneal Dystrophy:

(show top 50)    (show all 121)
idTitleAuthorsYear
1
Lattice Corneal Dystrophy Type IIIA With Hyaline Component From a Novel A620P Mutation and Distinct Surgical Treatments. (25321938)
2014
2
Lattice corneal dystrophy type 1: an epithelial or stromal entity? (25055147)
2014
3
Development of allele specific gene silencing siRNAs for TGFBI Arg124Cys in Lattice Corneal Dystrophy Type I. (24425855)
2014
4
Late-onset lattice corneal dystrophy without typical lattice lines caused by a novel mutation in the TGFBI gene. (24473223)
2014
5
Lattice Corneal Dystrophy-Variant: a report of three new cases due to p.V631D mutation in the TGFBI gene. (23455751)
2013
6
Unilateral Variant of Late-Onset Lattice Corneal Dystrophy With the Pro501Thr Mutation in the TGFBI Gene Without Deposits in the Unaffected Cornea Using Confocal Microscopy. (23884333)
2013
7
Genetic and phenotypic investigation of a Chinese pedigree with lattice corneal dystrophy IIIB subtype. (24579556)
2013
8
New mode of treatment for lattice corneal dystrophy type I: corneal epithelial debridement and fibronectin eye drops. (22080335)
2012
9
Genotype of lattice corneal dystrophy (R124C mutation in TGFBI) in a patient presenting with features of Avellino corneal dystrophy. (21617530)
2011
10
Unique TGFBI protein in lattice corneal dystrophy. (21948648)
2011
11
A novel mutation in transforming growth factor-beta induced protein (TGFI^Ip) reveals secondary structure perturbation in lattice corneal dystrophy. (21835759)
2011
12
Novel and known mutations of TGFBI, their genotype-phenotype correlation and structural modeling in 3 Chinese families with lattice corneal dystrophy. (20161820)
2010
13
Genotype of lattice corneal dystrophy (R124C mutation in TGFBI) in a patient presenting with features of avellino corneal dystrophy. (20458218)
2010
14
Lattice corneal dystrophy, gelsolin type (Meretoja's syndrome). (19832730)
2009
15
Double mutation (R124H, N544S) of TGFBI in two sisters with combined expression of Avellino and lattice corneal dystrophies. (19461933)
2009
16
Alterations of epithelial adhesion molecules and basement membrane components in lattice corneal dystrophy (LCD). (19190930)
2009
17
The TGFBI A546D mutation causes an atypical type of lattice corneal dystrophy. (17893671)
2007
18
Recurrence of lattice corneal dystrophy caused by incomplete removal of stroma after deep lamellar keratoplasty. (17001192)
2006
19
Delayed corneal epithelial wound healing after penetrating keratoplasty in individuals with lattice corneal dystrophy. (16815275)
2006
20
A novel H572R mutation in the transforming growth factor-beta-induced gene in a Thai family with lattice corneal dystrophy type I. (17013691)
2006
21
Excimer laser phototherapeutic keratectomy for granular and lattice corneal dystrophy: a comparative study. (16329366)
2005
22
Molecular genetic study on patients with lattice corneal dystrophy in China]. (16008913)
2005
23
First genetic analysis of lattice corneal dystrophy type I in a family from Bulgaria. (16329070)
2005
24
Two mutations in the TGFBI (BIGH3) gene associated with lattice corneal dystrophy in an extensively studied family. (15111592)
2004
25
Lattice corneal dystrophy type I without typical lattice lines: role of mutational analysis. (15013897)
2004
26
Lattice corneal dystrophy. (15693341)
2004
27
Penetrating limbo-keratoplasty for granular and lattice corneal dystrophy: survival of donor limbal stem cells and intermediate-term clinical results. (15288983)
2004
28
A novel nonsense mutation with a compound heterozygous mutation in TGFBI gene in lattice corneal dystrophy type I. (12586172)
2003
29
Allelic homogeneity due to a founder mutation in Japanese patients with lattice corneal dystrophy type IIIA. (12400061)
2002
30
R124C mutation of the betaIGH3 gene leads to remarkable phenotypic variability in a Greek four-generation family with lattice corneal dystrophy type 1. (11741113)
2001
31
Gelatino-lattice corneal dystrophy: clinical features and mutational analysis. (10844062)
2000
32
A new mutation (A546T) of the betaig-h3 gene responsible for a French lattice corneal dystrophy type IIIA. (10682981)
2000
33
Lattice corneal dystrophy. (10964807)
2000
34
Confocal microscopy in lattice corneal dystrophy. (10459621)
1999
35
Amyloid and Pro501 Thr-mutated (beta)ig-h3 gene product colocalize in lattice corneal dystrophy type IIIA. (10218700)
1999
36
Ultrastructural localization of gelsolin in lattice corneal dystrophy type I. (9787234)
1998
37
Arg124Cys mutation of the betaig-h3 bene in a Japanese family with lattice corneal dystrophy type I. (9886734)
1998
38
Transforming growth factor-beta induced protein, betaIG-H3, is present in degraded form and altered localization in lattice corneal dystrophy type I. (9657906)
1998
39
Lattice corneal dystrophy type 1 in a Canadian kindred is associated with the Arg124 --> Cys mutation in the kerato-epithelin gene. sgupta@ogh.on.ca. (9559741)
1998
40
Type I lattice corneal dystrophy. Clinical and molecular genetic study of a large family]. (9592740)
1998
41
Lattice corneal dystrophy: epithelial macroerosions in clear corneal grafts. (9676921)
1998
42
Granular-lattice corneal dystrophy. (8053808)
1994
43
Juxtapapillary choroidal neovascular membrane in a patient with Paget's disease and lattice corneal dystrophy. (2477432)
1989
44
Recurrence of the clinical signs of lattice corneal dystrophy (type I) in corneal transplants. (6364818)
1984
45
Recurrence of lattice corneal dystrophy type 1 in the corneal grafts of two siblings. (6753590)
1982
46
Diagnosis of early lattice corneal dystrophy. (6979328)
1982
47
Lattice corneal dystrophy. Report of an unusual case. (300621)
1977
48
Lattice corneal dystrophy. (779730)
1976
49
Primary familial corneal amyloidosis (lattice corneal dystrophy). (5298242)
1967
50
Lattice corneal dystrophy. An inherited variety of amyloidosis restricted to the cornea. (4163628)
1967

Variations for Lattice Corneal Dystrophy

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Expression for genes affiliated with Lattice Corneal Dystrophy

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Search GEO for disease gene expression data for Lattice Corneal Dystrophy.

Pathways for genes affiliated with Lattice Corneal Dystrophy

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Pathways related to Lattice Corneal Dystrophy according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4GSN, TGIF1
29.2GSN, TGFB1
39.0TGFB1, TGIF1
4
TGF-beta signaling pathway (KEGG)
Show member pathways
9.0TGFB1, TGIF1
59.0TGFB1, TGIF1

GO Terms for genes affiliated with Lattice Corneal Dystrophy

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Cellular components related to Lattice Corneal Dystrophy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:00725629.6GSN, TGFB1
2lateral plasma membraneGO:00163289.1TACSTD2, TBCD
3extracellular spaceGO:00056158.3GSN, TACSTD2, TGFB1, TGFBI

Biological processes related to Lattice Corneal Dystrophy according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1oligodendrocyte developmentGO:00140039.7GSN, TGFB1
2positive regulation of fibroblast proliferationGO:00481469.4TGFB1, TGIF1
3wound healingGO:00420609.2GSN, TGFB1
4chondrocyte differentiationGO:00020629.1TGFB1, TGFBI
5cellular response to growth factor stimulusGO:00713639.1TGFB1, TGIF1
6cell proliferationGO:00082838.8TACSTD2, TGFB1, TGFBI
7transforming growth factor beta receptor signaling pathwayGO:00071798.7TGFB1, TGIF1

Sources for Lattice Corneal Dystrophy

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet