MCID: LTT001
MIFTS: 32

Lattice Corneal Dystrophy malady

Categories: Genetic diseases, Eye diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Lattice Corneal Dystrophy

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Aliases & Descriptions for Lattice Corneal Dystrophy:

Name: Lattice Corneal Dystrophy 11 50 13
Familial Amyloid Neuropathy, Finnish Type 11
 
Familial Amyloid Polyneuropathy, Type V 68

Classifications:



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Disease Ontology11 DOID:8943
MeSH39 C537935

Summaries for Lattice Corneal Dystrophy

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Wikipedia:71 Lattice corneal dystrophy type, also known as Biber-Haab-Dimmer dystrophy, is a rare form of corneal... more...

MalaCards based summary: Lattice Corneal Dystrophy, also known as familial amyloid neuropathy, finnish type, is related to corneal dystrophy, gelatinous drop-like and corneal dystrophy, avellino type. An important gene associated with Lattice Corneal Dystrophy is TGFBI (Transforming Growth Factor Beta Induced), and among its related pathways are Coregulation of Androgen receptor activity and TGF Beta Signaling Pathway. Affiliated tissues include eye and kidney, and related mouse phenotypes are neoplasm and cellular.

Related Diseases for Lattice Corneal Dystrophy

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Diseases in the Lattice Corneal Dystrophy family:

Corneal Dystrophy, Lattice Type I Corneal Dystrophy, Lattice Type Iiia
Lattice Corneal Dystrophy Type Ii

Diseases related to Lattice Corneal Dystrophy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)
idRelated DiseaseScoreTop Affiliating Genes
1corneal dystrophy, gelatinous drop-like32.6GSN, TACSTD2, TGFBI
2corneal dystrophy, avellino type32.2TACSTD2, TBCD, TGFBI
3corneal dystrophy, lattice type iiia32.0TBCD, TGFBI, TGIF1
4lattice corneal dystrophy type ii12.5
5corneal dystrophy, lattice type i12.1
6amyloidosis, finnish type11.8
7familial amyloidosis, finnish type11.3
8corneal dystrophy10.9
9amyloidosis10.4
10urinary schistosomiasis10.1GSN, TGFB1
11polyneuropathy10.0
12lower gum cancer10.0GSN, TGFBI
13cerebral artery occlusion10.0TACSTD2, TGFBI
14calpainopathy10.0FAS, TGFB1
15sinusitis9.9FAS, TGFB1
16cataract9.9
17juvenile glaucoma9.9
18choroiditis9.9
19autonomic neuropathy9.9
20recurrent corneal erosion9.9
21corneal degeneration9.9
22neuropathy9.9
23lipodystrophy, familial partial, type 69.9TGFB1, TGIF1
24acute serous otitis media9.8GSN, TACSTD2, TGFBI
25retinal drusen9.8GSN, TACSTD2, TGFBI
26epidemic typhus9.8TGFB1, TGIF1
27corneal dystrophy, reis-bucklers type9.8GSN, TGFBI, TGIF1
28asbestosis9.7FAS, TGFB1
29eczematous dermatitis of eyelid9.5FAS, TGFB1
30stromal dystrophy9.5TACSTD2, TBCD, TGFBI
31corneal dystrophy, epithelial basement membrane9.2GSN, TACSTD2, TBCD, TGFBI
32sideroblastic anemia7.8FAS, GSN, TACSTD2, TBCD, TGFB1, TGFBI

Graphical network of the top 20 diseases related to Lattice Corneal Dystrophy:



Diseases related to lattice corneal dystrophy

Symptoms & Phenotypes for Lattice Corneal Dystrophy

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MGI Mouse Phenotypes related to Lattice Corneal Dystrophy according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5FAS, TACSTD2, TGFB1, TGFBI
2MP:00053848.4FAS, GSN, TACSTD2, TGFB1, TGFBI, TGIF1
3MP:00053768.3FAS, GSN, TACSTD2, TGFB1, TGFBI, TGIF1

Drugs & Therapeutics for Lattice Corneal Dystrophy

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Lattice Corneal Dystrophy

Genetic Tests for Lattice Corneal Dystrophy

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Anatomical Context for Lattice Corneal Dystrophy

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MalaCards organs/tissues related to Lattice Corneal Dystrophy:

36
Eye, Kidney

Publications for Lattice Corneal Dystrophy

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Articles related to Lattice Corneal Dystrophy:

(show top 50)    (show all 126)
idTitleAuthorsYear
1
Epigallocatechin Gallate Remodels Fibrils of Lattice Corneal Dystrophy Protein, Facilitating Proteolytic Degradation and Preventing Formation of Membrane-Permeabilizing Species. (27042751)
2016
2
Delayed Onset of Lattice Corneal Dystrophy Type IIIA Due to a Novel T621P Mutation in TGFBI. (27163623)
2016
3
Variant lattice corneal dystrophy associated with compound heterozygous mutations in the TGFBI gene. (27402970)
2016
4
Novel TGFBI mutation p.(Leu558Arg) in a lattice corneal dystrophy patient. (27028151)
2016
5
A Korean patient with lattice corneal dystrophy type IV with Leu527Arg mutation in the TGFBI gene. (24505203)
2014
6
Recurrent Amyloid Material in Grafts Used in Patients with Lattice Corneal Dystrophy 2 (Meretoja's Syndrome). (25741526)
2014
7
Lattice Corneal Dystrophy Type IIIA With Hyaline Component From a Novel A620P Mutation and Distinct Surgical Treatments. (25321938)
2014
8
Lattice corneal dystrophy type 1: an epithelial or stromal entity? (25055147)
2014
9
Development of allele specific gene silencing siRNAs for TGFBI Arg124Cys in Lattice Corneal Dystrophy Type I. (24425855)
2014
10
Late-onset lattice corneal dystrophy without typical lattice lines caused by a novel mutation in the TGFBI gene. (24473223)
2014
11
Lattice Corneal Dystrophy: a report of two cases in twin sisters due to 3 mutations (T1620C, C1416T, A1924G) in the TGFBI (BIGH3) gene. (24589966)
2014
12
Persistent staining of lattice lines after intraoperative trypan blue use in patients with lattice corneal dystrophy. (25255137)
2014
13
Comparison of two phenotypically distinct lattice corneal dystrophies caused by mutations in the transforming growth factor beta induced (TGFBI) gene. (24302499)
2014
14
Lattice Corneal Dystrophy-Variant: a report of three new cases due to p.V631D mutation in the TGFBI gene. (23455751)
2013
15
Unilateral Variant of Late-Onset Lattice Corneal Dystrophy With the Pro501Thr Mutation in the TGFBI Gene Without Deposits in the Unaffected Cornea Using Confocal Microscopy. (23884333)
2013
16
Genetic and phenotypic investigation of a Chinese pedigree with lattice corneal dystrophy IIIB subtype. (24579556)
2013
17
New mode of treatment for lattice corneal dystrophy type I: corneal epithelial debridement and fibronectin eye drops. (22080335)
2012
18
A novel mutation in transforming growth factor-beta induced protein (TGFI^Ip) reveals secondary structure perturbation in lattice corneal dystrophy. (21835759)
2011
19
Heavy-chain amyloidosis in TGFBI-negative and gelsolin-negative atypical lattice corneal dystrophy. (21743312)
2011
20
A novel mutation of the TGFBI gene causing a lattice corneal dystrophy with deep stromal involvement. (20974628)
2011
21
Genotype of lattice corneal dystrophy (R124C mutation in TGFBI) in a patient presenting with features of Avellino corneal dystrophy. (21617530)
2011
22
Unique TGFBI protein in lattice corneal dystrophy. (21948648)
2011
23
Novel and known mutations of TGFBI, their genotype-phenotype correlation and structural modeling in 3 Chinese families with lattice corneal dystrophy. (20161820)
2010
24
Genotype of lattice corneal dystrophy (R124C mutation in TGFBI) in a patient presenting with features of avellino corneal dystrophy. (20458218)
2010
25
Different phenotypes of lattice corneal dystrophy type I in patients with 417C>T (R124C) and 1762A>G (H572R) mutations in TGFBI (BIGH3). (20806046)
2010
26
Case of lattice corneal dystrophy due to L527R mutation in the TGFBI gene with asymmetric corneal opacity in eye laterality. (21191728)
2010
27
Lattice corneal dystrophy type IV (p.Leu527Arg) is caused by a founder mutation of the TGFBI gene in a single Japanese ancestor. (20357204)
2010
28
A novel mutation I522N within the TGFBI gene caused lattice corneal dystrophy I. (19956413)
2009
29
Corneal melt in lattice corneal dystrophy type II after cataract surgery. (19101443)
2009
30
Lattice corneal dystrophy, gelsolin type (Meretoja's syndrome). (19832730)
2009
31
Double mutation (R124H, N544S) of TGFBI in two sisters with combined expression of Avellino and lattice corneal dystrophies. (19461933)
2009
32
Alterations of epithelial adhesion molecules and basement membrane components in lattice corneal dystrophy (LCD). (19190930)
2009
33
Classic lattice corneal dystrophy associated with monoclonal gammopathy after exclusion of a TGFBI mutation. (19092416)
2009
34
A novel variant of combined granular-lattice corneal dystrophy associated with the Met619Lys mutation in the TGFBI gene. (18332318)
2008
35
Anticipation in familial lattice corneal dystrophy type I with R124C mutation in the TGFBI (BIGH3) gene. (18470323)
2008
36
Atypical asymmetric lattice corneal dystrophy associated with a novel homozygous mutation (Val624Met) in the TGFBI gene. (18385782)
2008
37
An R124C mutation in TGFBI caused lattice corneal dystrophy type I with a variable phenotype in three Chinese families. (18615206)
2008
38
A late-onset unilateral variant of lattice corneal dystrophy not associated with a TGFBI mutation. (18303168)
2008
39
The TGFBI A546D mutation causes an atypical type of lattice corneal dystrophy. (17893671)
2007
40
A clinical and histopathologic examination of accelerated TGFBIp deposition after LASIK in combined granular-lattice corneal dystrophy. (17317389)
2007
41
A novel variant lattice corneal dystrophy caused by association of mutation (V625D) in TGFBI gene. (17765440)
2007
42
Delayed epithelial healing after keratoplasty for lattice corneal dystrophy. (18043172)
2007
43
Lattice corneal dystrophy type II: clinical, pathologic, and molecular study in a Spanish family. (17534828)
2007
44
Recurrence of lattice corneal dystrophy caused by incomplete removal of stroma after deep lamellar keratoplasty. (17001192)
2006
45
A clinical and molecular-genetic analysis of Chinese patients with lattice corneal dystrophy and novel Thr538Pro mutation in the TGFBI (BIGH3) gene. (16809844)
2006
46
Delayed corneal epithelial wound healing after penetrating keratoplasty in individuals with lattice corneal dystrophy. (16815275)
2006
47
A novel H572R mutation in the transforming growth factor-beta-induced gene in a Thai family with lattice corneal dystrophy type I. (17013691)
2006
48
Unilateral lattice corneal dystrophy associated with the novel His572del mutation in the TGFBI gene. (16541014)
2006
49
Lattice corneal dystrophy type III in patients with a homozygous L527R mutation in the TGFBI gene. (16453189)
2006
50
An atypical presentation of lattice corneal dystrophy in a patient with juvenile glaucoma. (16167073)
2006

Variations for Lattice Corneal Dystrophy

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Expression for genes affiliated with Lattice Corneal Dystrophy

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Search GEO for disease gene expression data for Lattice Corneal Dystrophy.

Pathways for genes affiliated with Lattice Corneal Dystrophy

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GO Terms for genes affiliated with Lattice Corneal Dystrophy

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Cellular components related to Lattice Corneal Dystrophy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1lateral plasma membraneGO:00163289.7TACSTD2, TBCD
2secretory granuleGO:00301419.3FAS, TGFB1
3extracellular spaceGO:00056158.6FAS, GSN, TACSTD2, TGFB1, TGFBI

Biological processes related to Lattice Corneal Dystrophy according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1hepatocyte apoptotic processGO:009728410.2FAS, GSN
2chondrocyte differentiationGO:000206210.1TGFB1, TGFBI
3oligodendrocyte developmentGO:001400310.1GSN, TGFB1
4cellular response to growth factor stimulusGO:007136310.0TGFB1, TGIF1
5cellular response to mechanical stimulusGO:007126010.0FAS, TGFB1
6extrinsic apoptotic signaling pathwayGO:009719110.0FAS, TGFB1
7liver regenerationGO:009742110.0FAS, TGFB1
8cell proliferationGO:00082839.7TACSTD2, TGFB1, TGFBI
9agingGO:00075689.6FAS, GSN, TGFB1
10T cell homeostasisGO:00430299.3FAS, TGFB1
11response to drugGO:00424939.2FAS, TGFB1, TGIF1

Sources for Lattice Corneal Dystrophy

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet