MCID: LTT001
MIFTS: 33

Lattice Corneal Dystrophy malady

Neuronal, Genetic categories

Summaries for Lattice Corneal Dystrophy

Sources:
64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:64 Lattice corneal dystrophy type, also known as Biber-Haab-Dimmer dystrophy, is a rare form of corneal... more...

MalaCards: Lattice Corneal Dystrophy, also known as familial amyloid neuropathy, finnish type, is related to lattice corneal dystrophy type 1 and amyloidosis. An important gene associated with Lattice Corneal Dystrophy is TGFBI (transforming growth factor, beta-induced, 68kDa), and among its related pathways are Packaging Of Telomere Ends and Coregulation of Androgen receptor activity. The compounds cmdb7 and vitamin d have been mentioned in the context of this disorder. Affiliated tissues include kidney and t cells.

Aliases & Classifications for Lattice Corneal Dystrophy

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic
Anatomical: Neuronal


Aliases & Descriptions:

lattice corneal dystrophy 8 10 45
familial amyloid neuropathy, finnish type 8
familial amyloid polyneuropathy, type v 61


External Ids:

Disease Ontology8 DOID:8943
MeSH35 C537935

Related Diseases for Lattice Corneal Dystrophy

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the lattice corneal dystrophy type 1 family:

lattice corneal dystrophy lattice corneal dystrophy type 3a
lattice corneal dystrophy type ii

Diseases related to Lattice Corneal Dystrophy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 34)
idRelated DiseaseScoreTop Affiliating Genes
1lattice corneal dystrophy type 131.2TGIF1, TGFBI, GSN
2amyloidosis31.1GSN
3amyloidosis corneal31.0TACSTD2, GSN, TGFBI
4corneal granular dystrophy31.0H3F3C, TBCD
5corneal dystrophy avellino type30.8TGFBI, TGIF1
6corneal disease30.6TGFBI, GSN, CHST6
7recurrent corneal erosion30.3TGFBI
8lattice corneal dystrophy type ii10.9
9lattice corneal dystrophy type 3a10.6
10finnish type amyloidosis10.5
11juvenile glaucoma10.2
12polycystic kidney disease10.2
13autonomic neuropathy10.2
14familial amyloidosis, finnish type10.2
15amyloid neuropathy10.2
16epithelial basement membrane corneal dystrophy10.2
17amyloidosis, secondary10.2
18renal clear cell carcinoma10.0GSN
19colon cancer10.0TGIF1
20macular corneal dystrophy10.0CHST6
21cutis laxa10.0GSN
22astrocytoma10.0TGIF1
23moyamoya disease10.0TGIF1
24keratoconus10.0TGFBI, GSN
25amyloid tumor10.0TGFBI, GSN
26hereditary hemorrhagic telangiectasia10.0TGFB1
27pancreatitis10.0TGFB1
28camurati-engelmann disease10.0TGIF1, TGFB1
29pancreatic cancer10.0TGFB1, TGIF1, TACSTD2
30colorectal cancer10.0TGFB1, TGFBI, GSN
31ovarian cancer10.0TGFB1, TGIF1, GSN
32pulmonary fibrosis10.0TGIF1, TGFB1
33corneal dystrophy10.0TGIF1, CHST6, TACSTD2, GSN, TGFBI
34primary hyperoxaluria10.0GSN, TGIF1, TGFB1

Graphical network of the top 20 diseases related to Lattice Corneal Dystrophy:



Diseases related to lattice corneal dystrophy

Clinical Features for Lattice Corneal Dystrophy

Drugs & Therapeutics for Lattice Corneal Dystrophy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Lattice Corneal Dystrophy

Drug clinical trials:

Search ClinicalTrials for Lattice Corneal Dystrophy

Search NIH Clinical Center for Lattice Corneal Dystrophy

Search CenterWatch for Lattice Corneal Dystrophy

Genetic Tests for Lattice Corneal Dystrophy

Anatomical Context for Lattice Corneal Dystrophy

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Lattice Corneal Dystrophy:

33
Kidney, T cells

Animal Models for Lattice Corneal Dystrophy or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Lattice Corneal Dystrophy

Sources:
51PubMed
See all sources

Articles related to Lattice Corneal Dystrophy:

(show top 50)    (show all 118)
idTitleAuthorsYear
1
Unilateral Variant of Late-Onset Lattice Corneal Dystrophy With the Pro501Thr Mutation in the TGFBI Gene Without Deposits in the Unaffected Cornea Using Confocal Microscopy. (23884333)
2013
2
Genotype of lattice corneal dystrophy (R124C mutation in TGFBI) in a patient presenting with features of Avellino corneal dystrophy. (21617530)
2011
3
Unique TGFBI protein in lattice corneal dystrophy. (21948648)
2011
4
A novel mutation of the TGFBI gene causing a lattice corneal dystrophy with deep stromal involvement. (20974628)
2011
5
Novel and known mutations of TGFBI, their genotype-phenotype correlation and structural modeling in 3 Chinese families with lattice corneal dystrophy. (20161820)
2010
6
Genotype of lattice corneal dystrophy (R124C mutation in TGFBI) in a patient presenting with features of avellino corneal dystrophy. (20458218)
2010
7
Lattice corneal dystrophy type IV (p.Leu527Arg) is caused by a founder mutation of the TGFBI gene in a single Japanese ancestor. (20357204)
2010
8
Alterations of epithelial adhesion molecules and basement membrane components in lattice corneal dystrophy (LCD). (19190930)
2009
9
Classic lattice corneal dystrophy associated with monoclonal gammopathy after exclusion of a TGFBI mutation. (19092416)
2009
10
Corneal melt in lattice corneal dystrophy type II after cataract surgery. (19101443)
2009
11
Anticipation in familial lattice corneal dystrophy type I with R124C mutation in the TGFBI (BIGH3) gene. (18470323)
2008
12
Gene symbol: TGFBI. Disease: Corneal dystrophy, lattice type. (18846615)
2008
13
An R124C mutation in TGFBI caused lattice corneal dystrophy type I with a variable phenotype in three Chinese families. (18615206)
2008
14
A novel variant lattice corneal dystrophy caused by association of mutation (V625D) in TGFBI gene. (17765440)
2007
15
Lattice corneal dystrophy type II: clinical, pathologic, and molecular study in a Spanish family. (17534828)
2007
16
Delayed corneal epithelial wound healing after penetrating keratoplasty in individuals with lattice corneal dystrophy. (16815275)
2006
17
A novel H572R mutation in the transforming growth factor-beta-induced gene in a Thai family with lattice corneal dystrophy type I. (17013691)
2006
18
Unilateral lattice corneal dystrophy associated with the novel His572del mutation in the TGFBI gene. (16541014)
2006
19
A clinical and molecular-genetic analysis of Chinese patients with lattice corneal dystrophy and novel Thr538Pro mutation in the TGFBI (BIGH3) gene. (16809844)
2006
20
Molecular genetic study on patients with lattice corneal dystrophy in China]. (16008913)
2005
21
Hereditary lattice corneal dystrophy is associated with corneal amyloid deposits enclosing C-terminal fragments of keratoepithelin. (15790870)
2005
22
Novel mutation (V505D) of the TGFBI gene found in a Chinese family with lattice corneal dystrophy, type I. (15838722)
2005
23
Recurrent corneal erosion (RCE) secondary to lattice dystrophy in a patient with acquired immune deficiency syndrome (AIDS). (16361033)
2005
24
Lattice corneal dystrophy type I without typical lattice lines: role of mutational analysis. (15013897)
2004
25
Penetrating limbo-keratoplasty for granular and lattice corneal dystrophy: survival of donor limbal stem cells and intermediate-term clinical results. (15288983)
2004
26
Anterior basement membrane corneal dystrophy and pseudo-unilateral lattice corneal dystrophy in a patient with recurrent corneal erosions. (15183802)
2004
27
Case of late onset and isolated lattice corneal dystrophy with Asn544Ser (N544S) mutation of transforming growth factor beta-induced (TGFBI, BIGH3) gene]. (15559315)
2004
28
Differences in amyloid deposition in primary and recurrent corneal lattice dystrophy type 1. (11917182)
2002
29
Corneal morphology and sensitivity in lattice dystrophy type II (familial amyloidosis, Finnish type). (11222521)
2001
30
Gelatino-lattice corneal dystrophy: clinical features and mutational analysis. (10844062)
2000
31
Lattice corneal dystrophy. (10964807)
2000
32
Granular-lattice (Avellino) corneal dystrophy. (9838259)
1999
33
Leu518Pro mutation of the beta ig-h3 gene causes lattice corneal dystrophy type I. (10482106)
1999
34
A mutation within exon 14 of the TGFBI (BIGH3) gene on chromosome 5q31 causes an asymmetric, late-onset form of lattice corneal dystrophy. (10328397)
1999
35
Homologous penetrating central limbokeratoplasty in granular and lattice corneal dystrophy. (10571296)
1999
36
Pseudoexfoliation syndrome in a patient with lattice corneal dystrophy. (10674861)
1998-1999
37
Ultrastructural localization of gelsolin in lattice corneal dystrophy type I. (9787234)
1998
38
Arg124Cys mutation of the betaig-h3 bene in a Japanese family with lattice corneal dystrophy type I. (9886734)
1998
39
Type I lattice corneal dystrophy. Clinical and molecular genetic study of a large family]. (9592740)
1998
40
Combined granular-lattice corneal dystrophy (Avellino) in a patient with no known Italian ancestry. (8925485)
1996
41
Juxtapapillary choroidal neovascular membrane in a patient with Paget's disease and lattice corneal dystrophy. (2477432)
1989
42
Clinical features of a newly recognized type of lattice corneal dystrophy. (3498366)
1987
43
Histopathologic and immunochemical features of lattice corneal dystrophy type III. (3498367)
1987
44
Specular microscopic findings of lattice corneal dystrophy. (3493986)
1987
45
Recurrence of lattice corneal dystrophy type 1 in the corneal grafts of two siblings. (6753590)
1982
46
Corneal elastosis in lattice corneal dystrophy: a clinicopathologic report. (6172764)
1981
47
Protein AA and lattice corneal dystrophy. (6989251)
1980
48
Partial characterization of amyloid proteins in inherited amyloidosis with lattice corneal dystrophy and in secondary amyloidosis. (305513)
1978
49
Lattice corneal dystrophy. Report of an unusual case. (300621)
1977
50
Comparative histopathological and clinical findings in eyes with lattice corneal dystrophy of two different types. (4115977)
1972

Genetic Variations for Lattice Corneal Dystrophy

Expression for genes affiliated with Lattice Corneal Dystrophy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Lattice Corneal Dystrophy

Search GEO for disease gene expression data for Lattice Corneal Dystrophy.

Pathways for genes affiliated with Lattice Corneal Dystrophy

Sources:
54Reactome, 38NCBI BioSystems Database, 4Cell Signaling Technology
See all sources

Pathways related to Lattice Corneal Dystrophy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.8TGFBI, GSN
29.7TGIF1, GSN
39.6TGFB1, TGFBI
49.5TGFB1, TGIF1
5
Hide members
9.5TGFB1, TGIF1
68.8CHST6, GSN, TGFBI, TGFB1

Compounds for genes affiliated with Lattice Corneal Dystrophy

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB
See all sources

Compounds related to Lattice Corneal Dystrophy according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1cmdb7459.5TGFB1, TGIF1
2vitamin d459.2TGFB1, TGIF1, GSN
3cytochalasin d45 6010.1TGFB1, TGIF1, GSN
4dihydrotestosterone45 29 11 2411.9GSN, TGIF1, TGFB1

GO Terms for genes affiliated with Lattice Corneal Dystrophy

Sources:
16Gene Ontology
See all sources

Cellular components related to Lattice Corneal Dystrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lateral plasma membraneGO:0163289.3TACSTD2, TBCD
2extracellular spaceGO:0056158.9TGFB1, TGFBI, GSN, TACSTD2

Products for genes affiliated with Lattice Corneal Dystrophy

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lattice Corneal Dystrophy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet