MCID: LTT001
MIFTS: 35

Lattice Corneal Dystrophy malady

Categories: Genetic diseases, Eye diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Lattice Corneal Dystrophy

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Aliases & Descriptions for Lattice Corneal Dystrophy:

Name: Lattice Corneal Dystrophy 10 47 12
Familial Amyloid Neuropathy, Finnish Type 10
 
Familial Amyloid Polyneuropathy, Type V 65

Classifications:



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Disease Ontology10 DOID:8943
MeSH36 C537935
UMLS65 C0155127

Summaries for Lattice Corneal Dystrophy

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Wikipedia:68 Lattice corneal dystrophy type, also known as Biber-Haab-Dimmer dystrophy, is a rare form of corneal... more...

MalaCards based summary: Lattice Corneal Dystrophy, also known as familial amyloid neuropathy, finnish type, is related to corneal dystrophy, avellino type and corneal dystrophy, gelatinous drop-like. An important gene associated with Lattice Corneal Dystrophy is TGFBI (Transforming Growth Factor Beta Induced), and among its related pathways are Coregulation of Androgen receptor activity and Senescence and Autophagy. Affiliated tissues include prostate, endothelial and eye, and related mouse phenotype cellular.

Related Diseases for Lattice Corneal Dystrophy

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Diseases in the Lattice Corneal Dystrophy family:

Corneal Dystrophy, Lattice Type I Corneal Dystrophy, Lattice Type Iiia
Lattice Corneal Dystrophy Type Ii

Diseases related to Lattice Corneal Dystrophy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
idRelated DiseaseScoreTop Affiliating Genes
1corneal dystrophy, avellino type32.5TACSTD2, TBCD, TGFBI
2corneal dystrophy, gelatinous drop-like32.5GSN, TACSTD2, TGFBI
3corneal dystrophy, lattice type iiia32.0TBCD, TGFBI, TGIF1
4lattice corneal dystrophy type ii12.5
5corneal dystrophy, lattice type i12.0
6amyloidosis, finnish type11.7
7familial amyloidosis, finnish type11.3
8corneal dystrophy11.1
9amyloidosis10.5
10posterior amorphous corneal dystrophy10.2TBCD, TGFBI
11chronic leukemia10.2TGFB1, TGFBI
12polyneuropathy10.2
13immunodeficiency 28, mycobacteriosis10.2TGFB1, TGFBI
14mixed cell type cancer10.1TGFB1, TGFBI
15marasmus10.1TGFB1, TGFBI
16ophthalmia nodosa10.1TGFB1, TGFBI
17otosclerosis 410.1GSN, TACSTD2
18cerebral atherosclerosis10.1TGFB1, TGFBI
19amenorrhea10.1GSN, TGFB1
20oral candidiasis10.1TGFB1, TGFBI
21yellow nail syndrome10.0TGFB1, TGFBI
22melorheostosis with osteopoikilosis10.0TGFB1, TGFBI
23cataract10.0
24juvenile glaucoma10.0
25choroiditis10.0
26autonomic neuropathy10.0
27recurrent corneal erosion10.0
28corneal degeneration10.0
29kidney disease10.0
30neuropathy10.0
31polycystic kidney disease10.0
32eczema herpeticum10.0GSN, TGFBI
33short qt syndrome10.0TGFB1, TGFBI
34malignant struma ovarii9.9TGFB1, TGFBI
35sezary's disease9.9TGFB1, TGFBI
36fuchs' endothelial dystrophy9.8GSN, TACSTD2, TGFBI
37ossifying fibroma9.8TGFB1, TGFBI
38cirrhosis, north american indian childhood type9.8GSN, TACSTD2, TGFBI
39acute hydrops keratoconus9.8GSN, TACSTD2, TGFBI
40cervicitis9.8GSN, TACSTD2, TGFBI
41epithelial-stromal tgfbi dystrophy9.8TACSTD2, TBCD, TGFBI
42temporal lobe epilepsy9.7TGFB1, TGFBI
43hypoinsulinemic hypoglycemia with hemihypertrophy9.7TGFB1, TGIF1
44corneal dystrophy, reis-bucklers type9.6GSN, TGFBI, TGIF1
45mitochondrial metabolism disease9.6TGFB1, TGFBI
46stromal dystrophy9.4GSN, TACSTD2, TBCD, TGFBI
47corneal dystrophy, epithelial basement membrane9.4GSN, TACSTD2, TBCD, TGFBI
48severe nonproliferative diabetic retinopathy8.0GSN, TACSTD2, TBCD, TGFB1, TGFBI, TGIF1

Graphical network of the top 20 diseases related to Lattice Corneal Dystrophy:



Diseases related to lattice corneal dystrophy

Symptoms for Lattice Corneal Dystrophy

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Drugs & Therapeutics for Lattice Corneal Dystrophy

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Lattice Corneal Dystrophy

Genetic Tests for Lattice Corneal Dystrophy

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Anatomical Context for Lattice Corneal Dystrophy

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MalaCards organs/tissues related to Lattice Corneal Dystrophy:

33
Prostate, Endothelial, Eye, Heart, Breast, Temporal lobe, Tongue

Animal Models for Lattice Corneal Dystrophy or affiliated genes

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MGI Mouse Phenotypes related to Lattice Corneal Dystrophy:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053847.6GSN, TACSTD2, TGFB1, TGFBI, TGIF1

Publications for Lattice Corneal Dystrophy

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Articles related to Lattice Corneal Dystrophy:

(show top 50)    (show all 126)
idTitleAuthorsYear
1
Delayed Onset of Lattice Corneal Dystrophy Type IIIA Due to a Novel T621P Mutation in TGFBI. (27163623)
2016
2
Lattice Corneal Dystrophy Type IIIA With Hyaline Component From a Novel A620P Mutation and Distinct Surgical Treatments. (25321938)
2014
3
Lattice corneal dystrophy type 1: an epithelial or stromal entity? (25055147)
2014
4
Development of allele specific gene silencing siRNAs for TGFBI Arg124Cys in Lattice Corneal Dystrophy Type I. (24425855)
2014
5
Late-onset lattice corneal dystrophy without typical lattice lines caused by a novel mutation in the TGFBI gene. (24473223)
2014
6
Lattice Corneal Dystrophy-Variant: a report of three new cases due to p.V631D mutation in the TGFBI gene. (23455751)
2013
7
Unilateral Variant of Late-Onset Lattice Corneal Dystrophy With the Pro501Thr Mutation in the TGFBI Gene Without Deposits in the Unaffected Cornea Using Confocal Microscopy. (23884333)
2013
8
Genetic and phenotypic investigation of a Chinese pedigree with lattice corneal dystrophy IIIB subtype. (24579556)
2013
9
New mode of treatment for lattice corneal dystrophy type I: corneal epithelial debridement and fibronectin eye drops. (22080335)
2012
10
Genotype of lattice corneal dystrophy (R124C mutation in TGFBI) in a patient presenting with features of Avellino corneal dystrophy. (21617530)
2011
11
Unique TGFBI protein in lattice corneal dystrophy. (21948648)
2011
12
A novel mutation in transforming growth factor-beta induced protein (TGFI^Ip) reveals secondary structure perturbation in lattice corneal dystrophy. (21835759)
2011
13
Novel and known mutations of TGFBI, their genotype-phenotype correlation and structural modeling in 3 Chinese families with lattice corneal dystrophy. (20161820)
2010
14
Genotype of lattice corneal dystrophy (R124C mutation in TGFBI) in a patient presenting with features of avellino corneal dystrophy. (20458218)
2010
15
Lattice corneal dystrophy, gelsolin type (Meretoja's syndrome). (19832730)
2009
16
Double mutation (R124H, N544S) of TGFBI in two sisters with combined expression of Avellino and lattice corneal dystrophies. (19461933)
2009
17
Alterations of epithelial adhesion molecules and basement membrane components in lattice corneal dystrophy (LCD). (19190930)
2009
18
The TGFBI A546D mutation causes an atypical type of lattice corneal dystrophy. (17893671)
2007
19
Recurrence of lattice corneal dystrophy caused by incomplete removal of stroma after deep lamellar keratoplasty. (17001192)
2006
20
Delayed corneal epithelial wound healing after penetrating keratoplasty in individuals with lattice corneal dystrophy. (16815275)
2006
21
A novel H572R mutation in the transforming growth factor-beta-induced gene in a Thai family with lattice corneal dystrophy type I. (17013691)
2006
22
Excimer laser phototherapeutic keratectomy for granular and lattice corneal dystrophy: a comparative study. (16329366)
2005
23
Molecular genetic study on patients with lattice corneal dystrophy in China]. (16008913)
2005
24
First genetic analysis of lattice corneal dystrophy type I in a family from Bulgaria. (16329070)
2005
25
Two mutations in the TGFBI (BIGH3) gene associated with lattice corneal dystrophy in an extensively studied family. (15111592)
2004
26
Lattice corneal dystrophy type I without typical lattice lines: role of mutational analysis. (15013897)
2004
27
Lattice corneal dystrophy. (15693341)
2004
28
A novel nonsense mutation with a compound heterozygous mutation in TGFBI gene in lattice corneal dystrophy type I. (12586172)
2003
29
Allelic homogeneity due to a founder mutation in Japanese patients with lattice corneal dystrophy type IIIA. (12400061)
2002
30
R124C mutation of the betaIGH3 gene leads to remarkable phenotypic variability in a Greek four-generation family with lattice corneal dystrophy type 1. (11741113)
2001
31
Gelatino-lattice corneal dystrophy: clinical features and mutational analysis. (10844062)
2000
32
A new mutation (A546T) of the betaig-h3 gene responsible for a French lattice corneal dystrophy type IIIA. (10682981)
2000
33
Confocal microscopy in lattice corneal dystrophy. (10459621)
1999
34
Amyloid and Pro501 Thr-mutated (beta)ig-h3 gene product colocalize in lattice corneal dystrophy type IIIA. (10218700)
1999
35
Ultrastructural localization of gelsolin in lattice corneal dystrophy type I. (9787234)
1998
36
Arg124Cys mutation of the betaig-h3 bene in a Japanese family with lattice corneal dystrophy type I. (9886734)
1998
37
Transforming growth factor-beta induced protein, betaIG-H3, is present in degraded form and altered localization in lattice corneal dystrophy type I. (9657906)
1998
38
Lattice corneal dystrophy type 1 in a Canadian kindred is associated with the Arg124 --> Cys mutation in the kerato-epithelin gene. sgupta@ogh.on.ca. (9559741)
1998
39
Type I lattice corneal dystrophy. Clinical and molecular genetic study of a large family]. (9592740)
1998
40
Lattice corneal dystrophy: epithelial macroerosions in clear corneal grafts. (9676921)
1998
41
Granular-lattice corneal dystrophy. (8053808)
1994
42
Juxtapapillary choroidal neovascular membrane in a patient with Paget's disease and lattice corneal dystrophy. (2477432)
1989
43
Recurrence of the clinical signs of lattice corneal dystrophy (type I) in corneal transplants. (6364818)
1984
44
Recurrence of lattice corneal dystrophy type 1 in the corneal grafts of two siblings. (6753590)
1982
45
Diagnosis of early lattice corneal dystrophy. (6979328)
1982
46
Lattice corneal dystrophy. Report of an unusual case. (300621)
1977
47
Lattice corneal dystrophy. (779730)
1976
48
Primary familial corneal amyloidosis (lattice corneal dystrophy). (5298242)
1967
49
Lattice corneal dystrophy. An inherited variety of amyloidosis restricted to the cornea. (4163628)
1967
50

Variations for Lattice Corneal Dystrophy

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Expression for genes affiliated with Lattice Corneal Dystrophy

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Search GEO for disease gene expression data for Lattice Corneal Dystrophy.

Pathways for genes affiliated with Lattice Corneal Dystrophy

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Pathways related to Lattice Corneal Dystrophy according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.4GSN, TGIF1
29.2GSN, TGFB1
39.0TGFB1, TGIF1
4
Show member pathways
9.0TGFB1, TGIF1
59.0TGFB1, TGIF1

GO Terms for genes affiliated with Lattice Corneal Dystrophy

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Biological processes related to Lattice Corneal Dystrophy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chondrocyte differentiationGO:00020629.4TGFB1, TGFBI
2transforming growth factor beta receptor signaling pathwayGO:00071799.0TGFB1, TGIF1
3oligodendrocyte developmentGO:00140038.9GSN, TGFB1

Sources for Lattice Corneal Dystrophy

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet