MCID: LTT008
MIFTS: 16

Lattice Corneal Dystrophy Type Ii malady

Neuronal, Genetic categories

Summaries for Lattice Corneal Dystrophy Type Ii

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21Genetics Home Reference, 33MalaCards
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Genetics Home Reference:21 Lattice corneal dystrophy type II is characterized by an accumulation of protein clumps called amyloid deposits in tissues throughout the body. The deposits frequently occur in blood vessel walls and basement membranes, which are thin, sheet-like structures that separate and support cells in many tissues. Amyloid deposits lead to characteristic signs and symptoms involving the eyes, nerves, and skin that worsen with age.

MalaCards: Lattice Corneal Dystrophy Type Ii, also known as meretoja syndrome, is related to lattice corneal dystrophy and transthyretin amyloidosis. An important gene associated with Lattice Corneal Dystrophy Type Ii is GSN (gelsolin). Affiliated tissues include skin.

Aliases & Classifications for Lattice Corneal Dystrophy Type Ii

Sources:
21Genetics Home Reference, 61UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic
Anatomical: Neuronal


Aliases & Descriptions:

lattice corneal dystrophy type ii 21 61
meretoja syndrome 21 61
amyloid cranial neuropathy with lattice corneal dystrophy 21
amyloidosis, hereditary, transthyretin-related 61
lattice corneal dystrophy, gelsolin type 21
familial amyloid polyneuropathy type iv 21
familial amyloidosis, finnish type 21
amyloidosis due to mutant gelsolin 21
gelsolin-related amyloidosis 21
amyloidosis, meretoja type 21
amyloidosis, finnish type 21
finnish type amyloidosis 61
kymenlaakso syndrome 21
amyloidosis v 21


Related Diseases for Lattice Corneal Dystrophy Type Ii

Sources:
17GeneCards, 18GeneDecks
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Diseases in the lattice corneal dystrophy type 1 family:

lattice corneal dystrophy lattice corneal dystrophy type 3a
lattice corneal dystrophy type ii

Diseases related to Lattice Corneal Dystrophy Type Ii via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1lattice corneal dystrophy10.8
2transthyretin amyloidosis10.6
3familial amyloidosis, finnish type10.5
4familial transthyretin amyloidosis10.5
5finnish type amyloidosis10.4
6amyloidosis10.4
7amyloidosis corneal10.4
8hereditary amyloidosis10.4
9familial amyloid polyneuropathy type 110.3

Graphical network of diseases related to Lattice Corneal Dystrophy Type Ii:



Diseases related to lattice corneal dystrophy type ii

Clinical Features for Lattice Corneal Dystrophy Type Ii

Drugs & Therapeutics for Lattice Corneal Dystrophy Type Ii

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5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Lattice Corneal Dystrophy Type Ii

Anatomical Context for Lattice Corneal Dystrophy Type Ii

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33MalaCards
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MalaCards organs/tissues related to Lattice Corneal Dystrophy Type Ii:

33
Skin

Animal Models for Lattice Corneal Dystrophy Type Ii or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Lattice Corneal Dystrophy Type Ii

Sources:
51PubMed
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Articles related to Lattice Corneal Dystrophy Type Ii:

idTitleAuthorsYear
1
Allelic homogeneity due to a founder mutation in Japanese patients with lattice corneal dystrophy type IIIA. (12400061)
2002
2
A new mutation (A546T) of the betaig-h3 gene responsible for a French lattice corneal dystrophy type IIIA. (10682981)
2000
3
Amyloid and Pro501 Thr-mutated (beta)ig-h3 gene product colocalize in lattice corneal dystrophy type IIIA. (10218700)
1999
4
A kerato-epithelin (beta-ig-h3) mutation in lattice corneal dystrophy type IIIA. (9497262)
1998
5
Lattice corneal dystrophy type IIIA. Clinical and histopathologic correlations. (2003794)
1991

Genetic Variations for Lattice Corneal Dystrophy Type Ii

Expression for genes affiliated with Lattice Corneal Dystrophy Type Ii

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lattice Corneal Dystrophy Type Ii

Search GEO for disease gene expression data for Lattice Corneal Dystrophy Type Ii.

Pathways for genes affiliated with Lattice Corneal Dystrophy Type Ii

Compounds for genes affiliated with Lattice Corneal Dystrophy Type Ii

GO Terms for genes affiliated with Lattice Corneal Dystrophy Type Ii

Products for genes affiliated with Lattice Corneal Dystrophy Type Ii

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lattice Corneal Dystrophy Type Ii

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet