MCID: LTT008
MIFTS: 19

Lattice Corneal Dystrophy Type Ii malady

Genetic diseases, Neuronal diseases, Eye diseases, Rare diseases categories
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Summaries for Lattice Corneal Dystrophy Type Ii

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21Genetics Home Reference, 33MalaCards
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Genetics Home Reference:21 Lattice corneal dystrophy type II is characterized by an accumulation of protein clumps called amyloid deposits in tissues throughout the body. The deposits frequently occur in blood vessel walls and basement membranes, which are thin, sheet-like structures that separate and support cells in many tissues. Amyloid deposits lead to characteristic signs and symptoms involving the eyes, nerves, and skin that worsen with age.

MalaCards: Lattice Corneal Dystrophy Type Ii, also known as meretoja syndrome, is related to lattice corneal dystrophy and corneal dystrophy. An important gene associated with Lattice Corneal Dystrophy Type Ii is GSN (gelsolin).

Aliases & Classifications for Lattice Corneal Dystrophy Type Ii

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21Genetics Home Reference, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Neuronal diseases, Eye diseases


Aliases & Descriptions:

lattice corneal dystrophy type ii 21 62
meretoja syndrome 21 62
amyloid cranial neuropathy with lattice corneal dystrophy 21
amyloidosis, hereditary, transthyretin-related 62
lattice corneal dystrophy, gelsolin type 21
familial amyloid polyneuropathy type iv 21
familial amyloidosis, finnish type 21
amyloidosis due to mutant gelsolin 21
gelsolin-related amyloidosis 21
amyloidosis, meretoja type 21
amyloidosis, finnish type 21
finnish type amyloidosis 62
kymenlaakso syndrome 21
amyloidosis v 21


Related Diseases for Lattice Corneal Dystrophy Type Ii

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17GeneCards, 18GeneDecks
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Diseases in the Lattice Corneal Dystrophy Type 1 family:

Lattice Corneal Dystrophy Lattice Corneal Dystrophy Type 3a
lattice corneal dystrophy type ii

Diseases related to Lattice Corneal Dystrophy Type Ii via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1lattice corneal dystrophy10.8
2corneal dystrophy10.7
3polyneuropathy10.5
4finnish type amyloidosis10.4
5amyloidosis10.4
6cataract10.4
7familial amyloidosis, finnish type10.4
8neuronitis10.2
9hereditary amyloidosis10.2

Graphical network of diseases related to Lattice Corneal Dystrophy Type Ii:



Diseases related to lattice corneal dystrophy type ii

Symptoms for Lattice Corneal Dystrophy Type Ii

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Drugs & Therapeutics for Lattice Corneal Dystrophy Type Ii

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Lattice Corneal Dystrophy Type Ii

Search NIH Clinical Center for Lattice Corneal Dystrophy Type Ii

Genetic Tests for Lattice Corneal Dystrophy Type Ii

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Anatomical Context for Lattice Corneal Dystrophy Type Ii

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Animal Models for Lattice Corneal Dystrophy Type Ii or affiliated genes

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Publications for Lattice Corneal Dystrophy Type Ii

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52PubMed
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Articles related to Lattice Corneal Dystrophy Type Ii:

idTitleAuthorsYear
1
Corneal melt in lattice corneal dystrophy type II after cataract surgery. (19101443)
2009
2
Lattice corneal dystrophy type II: clinical, pathologic, and molecular study in a Spanish family. (17534828)
2007
3
Lattice corneal dystrophy type II associated with familial amyloid polyneuropathy type IV. (8684801)
1996
4
Lattice corneal dystrophy type II with familial amyloid polyneuropathy type IV. (8145387)
1993
5
Amyloidosis due to a mutation of the gelsolin gene in an American family with lattice corneal dystrophy type II. (1658654)
1991

Variations for Lattice Corneal Dystrophy Type Ii

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1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Lattice Corneal Dystrophy Type Ii:

1
id Gene Name Type Significance SNP ID Assembly Location
1GSNNM_001127666.1(GSN): c.520G> A (p.Asp174Asn)single nucleotide variantPathogenicrs121909715GRCh37Chr 9, 124073097: 124073097

Expression for genes affiliated with Lattice Corneal Dystrophy Type Ii

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lattice Corneal Dystrophy Type Ii

Search GEO for disease gene expression data for Lattice Corneal Dystrophy Type Ii.

Pathways for genes affiliated with Lattice Corneal Dystrophy Type Ii

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Compounds for genes affiliated with Lattice Corneal Dystrophy Type Ii

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GO Terms for genes affiliated with Lattice Corneal Dystrophy Type Ii

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Products for genes affiliated with Lattice Corneal Dystrophy Type Ii

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lattice Corneal Dystrophy Type Ii

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet