MCID: LDP002
MIFTS: 56

Lead Poisoning malady

Genetic diseases, Rare diseases categories

Summaries for Lead Poisoning

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Sources:
35MedlinePlus, 4CDC, 66Wikipedia, 48OMIM, 34MalaCards
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MedlinePlus:35 Lead is a metal that occurs naturally in the earth's crust. lead can be found in all parts of our environment. much of it comes from human activities such as mining and manufacturing. lead used to be in paint; older houses may still have lead paint. you could be exposed to lead by eating food or drinking water that contains lead. water pipes in older homes may contain lead. working in a job where lead is used using lead in a hobby, such as making stained glass or lead-glazed pottery using folk remedies such as herbs or foods that contain lead breathing air, drinking water, eating food, or swallowing or touching dirt that contains lead can cause many health problems. lead can affect almost every organ and system in your body. in adults, lead can increase blood pressure and cause infertility, nerve disorders, and muscle and joint pain. it can also make you irritable and affect your ability to concentrate and remember. lead is especially dangerous for children. a child who swallows large amounts of lead may develop anemia, severe stomachache, muscle weakness, and brain damage. even at low levels, lead can affect a child's mental and physical growth. agency for toxic substances disease registry

MalaCards: Lead Poisoning, also known as lead intoxication, is related to porphyria and acute intermittent porphyria. An important gene associated with Lead Poisoning is ALAD (aminolevulinate dehydratase), and among its related pathways are Vitamin D synthesis and Nuclear receptors in lipid metabolism and toxicity. The compounds dmsa and uroporphyrin have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and kidney, and related mouse phenotypes are limbs/digits/tail and growth/size/body.

CDC:4 Today at least 4 million households have children living in them that are being exposed to high levels of lead. There are approximately half a million U.S. children ages 1-5 with blood lead levels above 5 micrograms per deciliter (µg/dL), the reference level at which CDC recommends public health actions be initiated.

Wikipedia:66 Lead poisoning (also known as plumbism, colica pictorum, saturnism, Devon colic, or painter\'s colic) is... more...

Description from OMIM:48 612740

Aliases & Classifications for Lead Poisoning

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Sources:
48OMIM, 50Orphanet, 35MedlinePlus, 27ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases


Characteristics (Orphanet epidemiological data):

50
lead poisoning:
Prevalence: 1-9/100000; Age of onset: Childhood


Aliases & Descriptions:

lead poisoning 48 50 35
lead intoxication 50
saturnism 50


External Ids:

ICD10 via Orphanet27 T56.0

Related Diseases for Lead Poisoning

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Lead Poisoning via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 126)
idRelated DiseaseScoreTop Affiliating Genes
1porphyria30.5ALAD, HFE
2acute intermittent porphyria30.3SOD1, ALAD
3hepatitis30.2CAT, HFE, GLUD1, GGT1
4multiple sclerosis30.2VDR, CYP27B1, NGF, ALB, GLUD1
5iron deficiency anemia30.2HFE, G6PD
6hereditary spherocytosis30.1G6PD, HFE
7deficiency anemia30.0G6PD, ALB, ALAD, HFE
8malaria30.0GLUD1, ALAD, ALB, G6PD
9amyotrophic lateral sclerosis30.0GLUD1, ALAD, SOD1, NGF
10meningitis30.0ALB, CAT
11asthma10.2
12erythropoietic protoporphyria10.2
13constipation10.2
14metaphyseal dysplasia10.2
15aminoaciduria10.2
16variegate porphyria10.1ALAD
17favism10.1G6PD
18hemosiderosis10.1HFE
19pyruvate kinase deficiency10.1G6PD
20methemoglobinemia10.1G6PD
21glutathione synthetase deficiency10.1GGT1
22choledocholithiasis10.1GGT1
23porphyria cutanea tarda10.1ALAD, HFE
24gallbladder disease10.1GGT1
25williams syndrome10.1VDR, CYP27B1
26vitamin d-dependent rickets type ii10.1CYP27B1, VDR
27rickets, vitamin d-resistant, type iia10.1VDR, CYP27B1
28hemoglobinopathy10.1HFE, G6PD
29renal cell carcinoma10.1
30x-linked hypophosphatemia10.1VDR, CYP27B1
31beta thalassemia10.1HFE, G6PD
32hypermethioninemia10.1SOD1
33diabetic cataract10.1G6PD, CAT
34iron metabolism disease10.1G6PD, HFE
35hypophosphatemia10.1VDR, CYP27B1
36primary hyperparathyroidism10.1VDR, CYP27B1
37osteoporosis, postmenopausal10.1VDR, CYP27B1
38osteomalacia10.1VDR, CYP27B1
39alpha thalassemia10.1HFE, G6PD
40kernicterus10.1G6PD, ALB
41rickets10.1VDR, CYP27B1
42vascular disease10.1CAT, NGF
43bilirubin metabolic disorder10.1ALB, G6PD
44autonomic neuropathy10.0ALB, NGF
45alcohol abuse10.0GGT1, HFE
46rhinitis10.0ALB
47hyperammonemia multi-gene panels10.0GLUD1, GGT1
48eye disease10.0NGF, CAT
49respiratory failure10.0CAT, G6PD
50tuberculosis10.0VDR, ALB

Graphical network of the top 20 diseases related to Lead Poisoning:



Diseases related to lead poisoning

Symptoms for Lead Poisoning

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Sources:
48OMIM
See all sources


Clinical features from OMIM:

612740

Drugs & Therapeutics for Lead Poisoning

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Lead Poisoning

Drug clinical trials:

Search ClinicalTrials for Lead Poisoning

Search NIH Clinical Center for Lead Poisoning

Search CenterWatch for Lead Poisoning

Genetic Tests for Lead Poisoning

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Anatomical Context for Lead Poisoning

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Sources:
34MalaCards
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MalaCards organs/tissues related to Lead Poisoning:

34
Brain, Bone, Kidney, Heart, Testes, Eye, Tongue, Spinal cord, Liver, Skin

Animal Models for Lead Poisoning or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Lead Poisoning:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.9GGT1, HFE, CYP27B1, VDR
2MP:00053787.7VDR, CYP27B1, NGF, G6PD, HFE, GLUD1
3MP:00053977.6VDR, CYP27B1, SOD1, G6PD, HFE, GGT1
4MP:00053797.6VDR, CYP27B1, SOD1, ALB, GLUD1, GGT1
5MP:00053847.1VDR, CYP27B1, SOD1, G6PD, CAT, ALB
6MP:00107686.5VDR, NGF, SOD1, G6PD, CAT, ALB
7MP:00053765.9GGT1, VDR, CYP27B1, NGF, SOD1, G6PD

Publications for Lead Poisoning

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Sources:
53PubMed
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Articles related to Lead Poisoning:

(show top 50)    (show all 509)
idTitleAuthorsYear
1
An ongoing lack of knowledge about lead poisoning. (23947313)
2013
2
Ayurvedic remedy for diabetes as a cause of lead poisoning: a case report. (22795818)
2012
3
Bluish pigmentation of the gingiva in a homeless patient: a quiz. Burton's line revealing chronic lead poisoning (plumbism). (21952674)
2012
4
Lead poisoning and the deceptive recovery of the critically endangered California condor. (22733770)
2012
5
What role does nutrition play in the prevention or treatment of childhood lead poisoning? (23102188)
2012
6
Lead poisoning in China: a health and human rights crisis. (23568949)
2012
7
Lead poisoning of a child associated with use of a Cambodian Amulet --- New York City, 2009. (21270744)
2011
8
Childhood lead poisoning from the smelter in TorreA^n, MAcxico. (21329917)
2011
9
Lead poisoning and asthma among low-income and African American children in Saginaw, Michigan. (21144501)
2011
10
Occupational lead poisoning in workers of traditional tile factories in Mashhad, Northeast of Iran. (23022779)
2010
11
Lead poisoning among internally displaced Roma, Ashkali and Egyptian children in the United Nations-Administered Province of Kosovo. (19897587)
2010
12
Applying Dixon and Dixon's Integrative Model for Environmental Health Research toward a critical analysis of childhood lead poisoning in Canada. (20154520)
2010
13
Neuropathy due to lead poisoning. (20436756)
2010
14
Severe lead poisoning caused by use of health supplements presenting as acute abdominal pain during pregnancy. (19622956)
2009
15
Emerging aspects of assessing lead poisoning in childhood. (22460284)
2009
16
A comparison of sodium calcium edetate (edetate calcium disodium) and succimer (DMSA) in the treatment of inorganic lead poisoning. (19852620)
2009
17
Dimercaptosuccinic acid (succimer; DMSA) in inorganic lead poisoning. (19663612)
2009
18
Benjamin Franklin's risk factors for gout and stones: from genes and diet to possible lead poisoning. (19244863)
2008
19
Lead poisoning due to adulterated marijuana. (18403778)
2008
20
Infantile lead poisoning from an Asian tongue powder: a case report & subsequent public health inquiry. (18608276)
2008
21
Lead poisoning and Burton's line. (18803541)
2008
22
Do the same houses poison many children? An investigation of lead poisoning in Rochester, New York, 1993-2004. (17639651)
2007
23
Interpreting and managing blood lead levels of less than 10 microg/dL in children and reducing childhood exposure to lead: recommendations of the Centers for Disease Control and Prevention Advisory Committee on Childhood Lead Poisoning Prevention. (17974722)
2007
24
Lead poisoning in wild birds from southern Spain: a comparative study of wetland areas and species affected, and trends over time. (16483652)
2007
25
Using state lead poisoning surveillance system data to assess false positive results of capillary testing. (17340181)
2007
26
A case of acute lead poisoning in a 2-year-old child. (16842402)
2006
27
Acute lead poisoning associated with backyard lead smelting in Jamaica. (17691233)
2006
28
Systemic lead poisoning due to an intra-articular bullet. (15887590)
2005
29
Lead poisoning in whooper and tundra swans. (15827233)
2005
30
Strategies for safe and effective therapeutic measures for chronic arsenic and lead poisoning. (15703449)
2005
31
Severe lead poisoning in the plastics industry: a report of three cases. (15662640)
2005
32
Altered mentation caused by polioencephalomalacia, hypernatremia, and lead poisoning. (15203227)
2004
33
Lead poisoning. (20019937)
2003
34
Childhood Lead Poisoning Prevention Program Memphis and Shelby County Health Department. (12369542)
2002
35
Influence of nutrient intake on blood lead levels of young children at risk for lead poisoning. (12460816)
2002
36
Childhood lead poisoning. (12580366)
2002
37
Assessment of cleaning to control lead dust in homes of children with moderate lead poisoning: treatment of lead-exposed children trial. (12460817)
2002
38
Lead poisoning. (11936047)
2001
39
Lead poisoning treatment--a continuing need (commentary). (11778663)
2001
40
Bite the bullet: lead poisoning after ingestion of 206 lead bullets. (11577935)
2001
41
Ohio APNs: lead poisoning knowledge and practices. (11930596)
2000
42
Radiological case of the month. Lead poisoning. (10632257)
2000
43
Re-emergence of lead poisoning from contaminated flour in a West Bank Palestinian village. (10926721)
2000
44
Association between iron deficiency and low-level lead poisoning in an urban primary care clinic. (10394314)
1999
45
Biomedical communication and the reaction to the Queensland childhood lead poisoning cases elsewhere in the world. (10885137)
1999
46
Cottage industry lead poisoning: this time, no paprika. (10078170)
1999
47
The effects of lead poisoning on expression of nerve growth factor gene of submandibular gland in mice]. (11864487)
1999
48
Decreasing childhood lead poisoning in New York City: 1970-1998. (10609601)
1999
49
Lead poisoning in a schizophrenic. (10085622)
1998
50
Determination of the activity of delta-aminolevulinic acid dehydratase--a method for the diagnosis of lead poisoning in birds]. (7940512)
1994

Variations for Lead Poisoning

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Sources:
65UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar)
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UniProtKB/Swiss-Prot genetic disease variations for Lead Poisoning:

65
id Symbol AA change Variation ID SNP ID
1ALADp.Gly133ArgVAR_003634
2ALADp.Arg240TrpVAR_003635
3ALADp.Ala274ThrVAR_003636
4ALADp.Val275MetVAR_003637
5ALADp.Val153MetVAR_020974

Clinvar genetic disease variations for Lead Poisoning:

1
id Gene Name Type Significance SNP ID Assembly Location
1ALADNM_000031.5(ALAD): c.397G> A (p.Gly133Arg)single nucleotide variantPathogenicrs121912980GRCh37Chr 9, 116153078: 116153078
2ALADNM_000031.5(ALAD): c.823G> A (p.Val275Met)single nucleotide variantPathogenicrs121912981GRCh37Chr 9, 116151365: 116151365
3ALADNM_000031.5(ALAD): c.718C> T (p.Arg240Trp)single nucleotide variantPathogenicrs121912982GRCh37Chr 9, 116151801: 116151801
4ALADNM_000031.5(ALAD): c.820G> A (p.Ala274Thr)single nucleotide variantPathogenicrs121912983GRCh37Chr 9, 116151368: 116151368
5ALADALAD, IVS3AS, C-A, -11single nucleotide variantPathogenic
6ALADALAD, IVS3AS, C-T, -11single nucleotide variantPathogenic

Expression for genes affiliated with Lead Poisoning

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lead Poisoning

Search GEO for disease gene expression data for Lead Poisoning.

Pathways for genes affiliated with Lead Poisoning

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Sources:
51PathCards, 39NCBI BioSystems Database, 52PharmGKB, 56Reactome, 5Cell Signaling Technology, 31KEGG
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Pathways related to Lead Poisoning according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7CYP27B1, VDR
29.7CYP27B1, VDR
3
Show member pathways
Vitamin B12 Metabolism39
9.3CAT, SOD1
49.3CAT, SOD1
5
Show member pathways
9.3CAT, SOD1
6
Show member pathways
9.3CAT, SOD1
79.3CAT, SOD1
89.3G6PD, CAT, GLUD1
99.1NGF, SOD1, GLUD1
10
Show member pathways
thioredoxin pathway39
8.0GGT1, ALB, CAT, SOD1
11
Show member pathways
7.1CYP27B1, G6PD, PSPH, CAT, ALB, ALAD

Compounds for genes affiliated with Lead Poisoning

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Sources:
46Novoseek, 25HMDB, 12DrugBank, 3BitterDB, 52PharmGKB, 30IUPHAR, 62Tocris Bioscience
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Compounds related to Lead Poisoning according to GeneCards/GeneDecks:

(show top 50)    (show all 189)
idCompoundScoreTop Affiliating Genes
1dmsa469.8VDR, G6PD, ALAD
2uroporphyrin469.7GGT1, HFE, ALAD
3zinc protoporphyrin469.7G6PD, ALAD, VDR
45-aminolevulinic acid46 2510.5VDR, ALAD, HFE
5bathocuproine469.3CAT, SOD1
6thiobarbituric acid469.3CAT, G6PD, SOD1
73-amino-1,2,4-triazole469.3CAT, SOD1, NGF
8sodium azide469.3G6PD, SOD1, CAT
9dehydroascorbic acid46 1210.3G6PD, SOD1, CAT
10tocopherol469.2G6PD, CAT, SOD1
11selegiline46 1210.2NGF, SOD1, CAT
12NADP259.0GLUD1, CAT, CYP27B1, G6PD
13glucose 6-phosphate46 259.9CAT, GLUD1, SOD1, G6PD
14hypoxanthine46 25 1210.9NGF, CAT, G6PD, SOD1
15copper46 259.9SOD1, ALAD, HFE, CAT
16vitamin b12468.9G6PD, GGT1, ALAD, ALB
17gssg468.9CAT, SOD1, G6PD, GGT1
18chloramphenicol46 3 52 1211.8CYP27B1, G6PD, NGF, CAT, VDR
19phosphorus468.8GGT1, ALB, CYP27B1, VDR
20dtpa468.8ALB, CAT, SOD1
21vitamin-e468.8CAT, SOD1, G6PD, GGT1
22betacarotene468.7VDR, GGT1, CAT, SOD1
23salicylic acid46 309.7G6PD, ALB, CAT, VDR
24glutamine468.6VDR, G6PD, NGF, GLUD1, GGT1
25heme30 25 1210.6HFE, CAT, ALAD, ALB, CYP27B1
26nadph46 259.6CYP27B1, SOD1, GLUD1, G6PD, CAT
27quercetin46 62 25 1211.6CAT, NGF, SOD1, GGT1
28malondialdehyde468.6G6PD, ALAD, GGT1, SOD1, CAT
29vitamin d468.6NGF, VDR, ALB, ALAD, CYP27B1
30valine468.5NGF, G6PD, GLUD1, GGT1
31superoxide46 259.5SOD1, G6PD, GLUD1, ALAD, CAT
32alpha lipoic acid468.5CAT, GGT1, G6PD, SOD1, NGF
33citrate468.4VDR, G6PD, CAT, ALB, GLUD1
34arsenite46 259.4GGT1, CAT, SOD1, VDR
35thyroxine46 259.3GGT1, G6PD, NGF, VDR, ALB
36alpha tocopherol468.0GGT1, CAT, SOD1, ALB, G6PD
37aspartate468.0VDR, ALB, G6PD, HFE, GLUD1, GGT1
38indomethacin46 30 62 1210.9ALB, GGT1, CAT, NGF, SOD1
39iron46 258.8HFE, ALAD, GGT1, ALB, SOD1, CAT
40mannitol46 128.7ALB, G6PD, GLUD1, GGT1, CAT, SOD1
41glucose467.7GGT1, GLUD1, HFE, ALB, CYP27B1, G6PD
42vitamin a46 25 129.7VDR, CAT, CYP27B1, GGT1, SOD1, ALB
43lactate467.5SOD1, GLUD1, ALAD, ALB, CAT, GGT1
44testosterone46 62 25 1210.4GGT1, NGF, VDR, HFE, ALAD, ALB
45alanine467.4SOD1, ALB, NGF, VDR, GGT1, GLUD1
46lipid467.1ALAD, GGT1, SOD1, G6PD, CAT, ALB
47uric acid46 258.1HFE, GGT1, GLUD1, ALAD, ALB, CAT
48creatinine467.1GGT1, VDR, NGF, SOD1, G6PD, ALB
49ascorbic acid46 258.0VDR, SOD1, G6PD, CAT, ALB, HFE
50cysteine466.6NGF, GGT1, HFE, CAT, ALB, GLUD1

GO Terms for genes affiliated with Lead Poisoning

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Sources:
17Gene Ontology
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Biological processes related to Lead Poisoning according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vitamin D 24-hydroxylase activityGO:0109809.9VDR, CYP27B1
2positive regulation of keratinocyte differentiationGO:0456189.9CYP27B1, VDR
3decidualizationGO:0466979.8CYP27B1, VDR
4cellular amino acid biosynthetic processGO:0086529.8PSPH, GLUD1
5response to nutrient levelsGO:0316679.6SOD1, PSPH
6glutathione metabolic processGO:0067499.1GGT1, G6PD, SOD1
7retina homeostasisGO:0018959.0ALB, SOD1
8response to organic substanceGO:0100338.7ALB, SOD1
9small molecule metabolic processGO:0442817.3GGT1, CYP27B1, G6PD, PSPH, CAT, ALB

Molecular functions related to Lead Poisoning according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1NADP bindingGO:0506619.6CAT, G6PD
2antioxidant activityGO:0162099.0ALB, CAT
3protein homodimerization activityGO:0428038.4CAT, PSPH, G6PD, SOD1

Products for genes affiliated with Lead Poisoning

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  • Antibodies
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Sources for Lead Poisoning

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet