MCID: LDP002
MIFTS: 57

Lead Poisoning malady

Genetic diseases, Rare diseases categories
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Summaries for Lead Poisoning

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MedlinePlus:33 Lead is a metal that occurs naturally in the earth's crust. lead can be found in all parts of our environment. much of it comes from human activities such as mining and manufacturing. lead used to be in paint; older houses may still have lead paint. you could be exposed to lead by eating food or drinking water that contains lead. water pipes in older homes may contain lead. working in a job where lead is used using lead in a hobby, such as making stained glass or lead-glazed pottery using folk remedies such as herbs or foods that contain lead breathing air, drinking water, eating food, or swallowing or touching dirt that contains lead can cause many health problems. lead can affect almost every organ and system in your body. in adults, lead can increase blood pressure and cause infertility, nerve disorders, and muscle and joint pain. it can also make you irritable and affect your ability to concentrate and remember. lead is especially dangerous for children. a child who swallows large amounts of lead may develop anemia, severe stomachache, muscle weakness, and brain damage. even at low levels, lead can affect a child's mental and physical growth. agency for toxic substances disease registry

MalaCards based summary: Lead Poisoning, also known as lead intoxication, is related to porphyria and iron deficiency anemia. An important gene associated with Lead Poisoning is ALAD (aminolevulinate dehydratase), and among its related pathways are Vitamin D synthesis and Nuclear receptors in lipid metabolism and toxicity. The compounds dmsa and uroporphyrin have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and kidney, and related mouse phenotypes are limbs/digits/tail and growth/size/body.

Wikipedia:65 Lead poisoning (also known as plumbism, colica pictorum, saturnism, Devon colic, or painter\'s colic) is... more...

Description from OMIM:46 612740

Aliases & Classifications for Lead Poisoning

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Sources:
46OMIM, 48Orphanet, 33MedlinePlus, 26ICD10 via Orphanet
See all sources

Lead Poisoning, Aliases & Descriptions:

Name: Lead Poisoning 46 48 33
Lead Intoxication 48
 
Saturnism 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases


Characteristics (Orphanet epidemiological data):

48
lead poisoning:
Prevalence: 1-9/100000; Age of onset: Childhood


External Ids:

ICD10 via Orphanet26 T56.0

Related Diseases for Lead Poisoning

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Diseases related to Lead Poisoning via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 129)
idRelated DiseaseScoreTop Affiliating Genes
1porphyria31.1ALAD, HFE
2iron deficiency anemia30.6HFE, G6PD
3acute intermittent porphyria30.5SOD1, ALAD
4hereditary spherocytosis30.5G6PD, HFE
5deficiency anemia30.1G6PD, ALB, ALAD, HFE
6hepatitis30.1CAT, HFE, GLUD1, GGT1
7malaria30.1GLUD1, ALAD, ALB, G6PD
8multiple sclerosis30.0VDR, CYP27B1, NGF, ALB, GLUD1
9meningitis29.8ALB, CAT
10variegate porphyria10.5ALAD
11favism10.5G6PD
12hemosiderosis10.5HFE
13pyruvate kinase deficiency10.5G6PD
14methemoglobinemia10.5G6PD
15glutathione synthetase deficiency10.4GGT1
16choledocholithiasis10.4GGT1
17porphyria cutanea tarda10.4ALAD, HFE
18gallbladder disease10.4GGT1
19williams syndrome10.4VDR, CYP27B1
20vitamin d-dependent rickets type ii10.4CYP27B1, VDR
21rickets, vitamin d-resistant, type iia10.4VDR, CYP27B1
22hemoglobinopathy10.3HFE, G6PD
23x-linked hypophosphatemia10.3VDR, CYP27B1
24beta thalassemia10.3HFE, G6PD
25hypermethioninemia10.3SOD1
26diabetic cataract10.3G6PD, CAT
27iron metabolism disease10.3G6PD, HFE
28hypophosphatemia10.3VDR, CYP27B1
29primary hyperparathyroidism10.3VDR, CYP27B1
30osteoporosis, postmenopausal10.3VDR, CYP27B1
31osteomalacia10.3VDR, CYP27B1
32alpha thalassemia10.3HFE, G6PD
33kernicterus10.3G6PD, ALB
34asthma10.3
35rickets10.2VDR, CYP27B1
36vascular disease10.2CAT, NGF
37bilirubin metabolic disorder10.2ALB, G6PD
38autonomic neuropathy10.2ALB, NGF
39alcohol abuse10.2GGT1, HFE
40rhinitis10.2ALB
41erythropoietic protoporphyria10.2
42hyperammonemia multi-gene panels10.2GLUD1, GGT1
43spiradenoma10.2NGF, CAT
44constipation10.2
45metaphyseal dysplasia10.2
46aminoaciduria10.2
47respiratory failure10.2CAT, G6PD
48tuberculosis10.1VDR, ALB
49secondary hyperparathyroidism of renal origin10.1VDR, CYP27B1, ALB
50portal hypertension10.1GGT1, ALB

Graphical network of the top 20 diseases related to Lead Poisoning:



Diseases related to lead poisoning

Symptoms for Lead Poisoning

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Clinical features from OMIM:

612740

Drugs & Therapeutics for Lead Poisoning

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Drug clinical trials:

Search ClinicalTrials for Lead Poisoning

Search NIH Clinical Center for Lead Poisoning

Genetic Tests for Lead Poisoning

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Anatomical Context for Lead Poisoning

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MalaCards organs/tissues related to Lead Poisoning:

32
Brain, Bone, Kidney, Heart, Testes, Eye, Spinal cord, Liver, Skin, Tongue

Animal Models for Lead Poisoning or affiliated genes

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MGI Mouse Phenotypes related to Lead Poisoning:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.9GGT1, HFE, CYP27B1, VDR
2MP:00053787.7VDR, CYP27B1, NGF, G6PD, HFE, GLUD1
3MP:00053977.6VDR, CYP27B1, SOD1, G6PD, HFE, GGT1
4MP:00053797.6VDR, CYP27B1, SOD1, ALB, GLUD1, GGT1
5MP:00053847.1VDR, CYP27B1, SOD1, G6PD, CAT, ALB
6MP:00107686.5VDR, NGF, SOD1, G6PD, CAT, ALB
7MP:00053765.9GGT1, VDR, CYP27B1, NGF, SOD1, G6PD

Publications for Lead Poisoning

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Articles related to Lead Poisoning:

(show top 50)    (show all 533)
idTitleAuthorsYear
1
Primary prevention of lead poisoning in children: a cross-sectional study to evaluate state specific lead-based paint risk reduction laws in preventing lead poisoning in children. (25380793)
2014
2
Congenital lead poisoning: an unusual presentation. (24757314)
2014
3
An ongoing lack of knowledge about lead poisoning. (23947313)
2013
4
Ayurvedic remedy for diabetes as a cause of lead poisoning: a case report. (22795818)
2012
5
Bluish pigmentation of the gingiva in a homeless patient: a quiz. Burton's line revealing chronic lead poisoning (plumbism). (21952674)
2012
6
Lead poisoning and the deceptive recovery of the critically endangered California condor. (22733770)
2012
7
What role does nutrition play in the prevention or treatment of childhood lead poisoning? (23102188)
2012
8
Lead poisoning in China: a health and human rights crisis. (23568949)
2012
9
Lead poisoning of a child associated with use of a Cambodian Amulet --- New York City, 2009. (21270744)
2011
10
Childhood lead poisoning from the smelter in TorreA^n, MAcxico. (21329917)
2011
11
Lead poisoning and asthma among low-income and African American children in Saginaw, Michigan. (21144501)
2011
12
Occupational lead poisoning in workers of traditional tile factories in Mashhad, Northeast of Iran. (23022779)
2010
13
Lead poisoning among internally displaced Roma, Ashkali and Egyptian children in the United Nations-Administered Province of Kosovo. (19897587)
2010
14
Applying Dixon and Dixon's Integrative Model for Environmental Health Research toward a critical analysis of childhood lead poisoning in Canada. (20154520)
2010
15
Neuropathy due to lead poisoning. (20436756)
2010
16
Severe lead poisoning caused by use of health supplements presenting as acute abdominal pain during pregnancy. (19622956)
2009
17
Emerging aspects of assessing lead poisoning in childhood. (22460284)
2009
18
A comparison of sodium calcium edetate (edetate calcium disodium) and succimer (DMSA) in the treatment of inorganic lead poisoning. (19852620)
2009
19
Dimercaptosuccinic acid (succimer; DMSA) in inorganic lead poisoning. (19663612)
2009
20
Benjamin Franklin's risk factors for gout and stones: from genes and diet to possible lead poisoning. (19244863)
2008
21
Lead poisoning due to adulterated marijuana. (18403778)
2008
22
Infantile lead poisoning from an Asian tongue powder: a case report & subsequent public health inquiry. (18608276)
2008
23
Lead poisoning and Burton's line. (18803541)
2008
24
Do the same houses poison many children? An investigation of lead poisoning in Rochester, New York, 1993-2004. (17639651)
2007
25
Interpreting and managing blood lead levels of less than 10 microg/dL in children and reducing childhood exposure to lead: recommendations of the Centers for Disease Control and Prevention Advisory Committee on Childhood Lead Poisoning Prevention. (17974722)
2007
26
Lead poisoning in wild birds from southern Spain: a comparative study of wetland areas and species affected, and trends over time. (16483652)
2007
27
Using state lead poisoning surveillance system data to assess false positive results of capillary testing. (17340181)
2007
28
A case of acute lead poisoning in a 2-year-old child. (16842402)
2006
29
Acute lead poisoning associated with backyard lead smelting in Jamaica. (17691233)
2006
30
Systemic lead poisoning due to an intra-articular bullet. (15887590)
2005
31
Lead poisoning in whooper and tundra swans. (15827233)
2005
32
Strategies for safe and effective therapeutic measures for chronic arsenic and lead poisoning. (15703449)
2005
33
Severe lead poisoning in the plastics industry: a report of three cases. (15662640)
2005
34
Altered mentation caused by polioencephalomalacia, hypernatremia, and lead poisoning. (15203227)
2004
35
Lead poisoning. (20019937)
2003
36
Childhood Lead Poisoning Prevention Program Memphis and Shelby County Health Department. (12369542)
2002
37
Influence of nutrient intake on blood lead levels of young children at risk for lead poisoning. (12460816)
2002
38
Childhood lead poisoning. (12580366)
2002
39
Assessment of cleaning to control lead dust in homes of children with moderate lead poisoning: treatment of lead-exposed children trial. (12460817)
2002
40
Lead poisoning. (11936047)
2001
41
Lead poisoning treatment--a continuing need (commentary). (11778663)
2001
42
Bite the bullet: lead poisoning after ingestion of 206 lead bullets. (11577935)
2001
43
Ohio APNs: lead poisoning knowledge and practices. (11930596)
2000
44
Radiological case of the month. Lead poisoning. (10632257)
2000
45
Re-emergence of lead poisoning from contaminated flour in a West Bank Palestinian village. (10926721)
2000
46
Association between iron deficiency and low-level lead poisoning in an urban primary care clinic. (10394314)
1999
47
Biomedical communication and the reaction to the Queensland childhood lead poisoning cases elsewhere in the world. (10885137)
1999
48
Cottage industry lead poisoning: this time, no paprika. (10078170)
1999
49
The effects of lead poisoning on expression of nerve growth factor gene of submandibular gland in mice]. (11864487)
1999
50
Determination of the activity of delta-aminolevulinic acid dehydratase--a method for the diagnosis of lead poisoning in birds]. (7940512)
1994

Variations for Lead Poisoning

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UniProtKB/Swiss-Prot genetic disease variations for Lead Poisoning:

64
id Symbol AA change Variation ID SNP ID
1ALADp.Gly133ArgVAR_003634
2ALADp.Arg240TrpVAR_003635
3ALADp.Ala274ThrVAR_003636
4ALADp.Val275MetVAR_003637
5ALADp.Val153MetVAR_020974

Clinvar genetic disease variations for Lead Poisoning:

6
id Gene Name Type Significance SNP ID Assembly Location
1ALADNM_000031.5(ALAD): c.397G> A (p.Gly133Arg)single nucleotide variantPathogenicrs121912980GRCh37Chr 9, 116153078: 116153078
2ALADNM_000031.5(ALAD): c.823G> A (p.Val275Met)single nucleotide variantPathogenicrs121912981GRCh37Chr 9, 116151365: 116151365
3ALADNM_000031.5(ALAD): c.718C> T (p.Arg240Trp)single nucleotide variantPathogenicrs121912982GRCh37Chr 9, 116151801: 116151801
4ALADNM_000031.5(ALAD): c.820G> A (p.Ala274Thr)single nucleotide variantPathogenicrs121912983GRCh37Chr 9, 116151368: 116151368
5ALADALAD, IVS3AS, C-A, -11single nucleotide variantPathogenic
6ALADALAD, IVS3AS, C-T, -11single nucleotide variantPathogenic

Expression for genes affiliated with Lead Poisoning

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Expression patterns in normal tissues for genes affiliated with Lead Poisoning

Search GEO for disease gene expression data for Lead Poisoning.

Pathways for genes affiliated with Lead Poisoning

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Pathways related to Lead Poisoning according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7VDR, CYP27B1
29.7VDR, CYP27B1
3
Show member pathways
Vitamin B12 Metabolism37
9.3CAT, SOD1
49.3CAT, SOD1
5
Show member pathways
9.3CAT, SOD1
6
Show member pathways
9.3SOD1, CAT
79.3CAT, SOD1
89.3GLUD1, CAT, G6PD
99.1NGF, SOD1, GLUD1
10
Show member pathways
thioredoxin pathway37
8.0SOD1, CAT, ALB, GGT1
11
Show member pathways
7.1GLUD1, ALB, GGT1, CAT, PSPH, ALAD

Compounds for genes affiliated with Lead Poisoning

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Compounds related to Lead Poisoning according to GeneCards/GeneDecks:

(show top 50)    (show all 189)
idCompoundScoreTop Affiliating Genes
1dmsa449.8VDR, G6PD, ALAD
2uroporphyrin449.7GGT1, HFE, ALAD
3zinc protoporphyrin449.7G6PD, ALAD, VDR
45-aminolevulinic acid44 2410.5VDR, ALAD, HFE
5bathocuproine449.3CAT, SOD1
6thiobarbituric acid449.3CAT, G6PD, SOD1
73-amino-1,2,4-triazole449.3CAT, SOD1, NGF
8sodium azide449.3G6PD, SOD1, CAT
9dehydroascorbic acid44 1110.3G6PD, SOD1, CAT
10tocopherol449.2G6PD, CAT, SOD1
11selegiline44 1110.2NGF, SOD1, CAT
12NADP249.0GLUD1, CAT, CYP27B1, G6PD
13glucose 6-phosphate44 249.9CAT, GLUD1, SOD1, G6PD
14hypoxanthine44 24 1110.9NGF, CAT, G6PD, SOD1
15copper44 249.9SOD1, ALAD, HFE, CAT
16vitamin b12448.9G6PD, GGT1, ALAD, ALB
17gssg448.9CAT, SOD1, G6PD, GGT1
18chloramphenicol44 2 50 1111.8CYP27B1, G6PD, NGF, CAT, VDR
19phosphorus448.8GGT1, ALB, CYP27B1, VDR
20dtpa448.8ALB, CAT, SOD1
21vitamin-e448.8CAT, SOD1, G6PD, GGT1
22betacarotene448.7VDR, GGT1, CAT, SOD1
23salicylic acid44 289.7G6PD, ALB, CAT, VDR
24glutamine448.6VDR, G6PD, NGF, GLUD1, GGT1
25heme28 24 1110.6HFE, CAT, ALAD, ALB, CYP27B1
26nadph44 249.6CYP27B1, SOD1, GLUD1, G6PD, CAT
27quercetin44 61 24 1111.6CAT, NGF, SOD1, GGT1
28malondialdehyde448.6G6PD, ALAD, GGT1, SOD1, CAT
29vitamin d448.6NGF, VDR, ALB, ALAD, CYP27B1
30valine448.5NGF, G6PD, GLUD1, GGT1
31superoxide44 249.5SOD1, G6PD, GLUD1, ALAD, CAT
32alpha lipoic acid448.5CAT, GGT1, G6PD, SOD1, NGF
33citrate448.4VDR, G6PD, CAT, ALB, GLUD1
34arsenite44 249.4GGT1, CAT, SOD1, VDR
35thyroxine44 249.3GGT1, G6PD, NGF, VDR, ALB
36alpha tocopherol448.0GGT1, CAT, SOD1, ALB, G6PD
37aspartate448.0VDR, ALB, G6PD, HFE, GLUD1, GGT1
38indomethacin44 28 61 1110.9ALB, GGT1, CAT, NGF, SOD1
39iron44 248.8HFE, ALAD, GGT1, ALB, SOD1, CAT
40mannitol44 118.7ALB, G6PD, GLUD1, GGT1, CAT, SOD1
41glucose447.7GGT1, GLUD1, HFE, ALB, CYP27B1, G6PD
42vitamin a44 24 119.7VDR, CAT, CYP27B1, GGT1, SOD1, ALB
43lactate447.5SOD1, GLUD1, ALAD, ALB, CAT, GGT1
44testosterone44 61 24 1110.4GGT1, NGF, VDR, HFE, ALAD, ALB
45alanine447.4SOD1, ALB, NGF, VDR, GGT1, GLUD1
46lipid447.1ALAD, GGT1, SOD1, G6PD, CAT, ALB
47uric acid44 248.1HFE, GGT1, GLUD1, ALAD, ALB, CAT
48creatinine447.1GGT1, VDR, NGF, SOD1, G6PD, ALB
49ascorbic acid44 248.0VDR, SOD1, G6PD, CAT, ALB, HFE
50cysteine446.6NGF, GGT1, HFE, CAT, ALB, GLUD1

GO Terms for genes affiliated with Lead Poisoning

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Biological processes related to Lead Poisoning according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vitamin D 24-hydroxylase activityGO:0109809.9VDR, CYP27B1
2positive regulation of keratinocyte differentiationGO:0456189.9CYP27B1, VDR
3decidualizationGO:0466979.8CYP27B1, VDR
4cellular amino acid biosynthetic processGO:0086529.8PSPH, GLUD1
5response to nutrient levelsGO:0316679.6SOD1, PSPH
6glutathione metabolic processGO:0067499.1GGT1, G6PD, SOD1
7retina homeostasisGO:0018959.0ALB, SOD1
8response to organic substanceGO:0100338.7ALB, SOD1
9small molecule metabolic processGO:0442817.3GGT1, CYP27B1, G6PD, PSPH, CAT, ALB

Molecular functions related to Lead Poisoning according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1NADP bindingGO:0506619.6CAT, G6PD
2antioxidant activityGO:0162099.0ALB, CAT
3protein homodimerization activityGO:0428038.4CAT, PSPH, G6PD, SOD1

Products for genes affiliated with Lead Poisoning

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  • Antibodies
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Sources for Lead Poisoning

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet