MCID: LDP002
MIFTS: 47

Lead Poisoning malady

Summaries for Lead Poisoning

Sources:
34MedlinePlus, 3CDC, 64Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 Lead is a metal that occurs naturally in the earth's crust. lead can be found in all parts of our environment. much of it comes from human activities such as mining and manufacturing. lead used to be in paint; older houses may still have lead paint. you could be exposed to lead by eating food or drinking water that contains lead. water pipes in older homes may contain lead. working in a job where lead is used using lead in a hobby, such as making stained glass or lead-glazed pottery using folk remedies such as herbs or foods that contain lead breathing air, drinking water, eating food, or swallowing or touching dirt that contains lead can cause many health problems. lead can affect almost every organ and system in your body. in adults, lead can increase blood pressure and cause infertility, nerve disorders, and muscle and joint pain. it can also make you irritable and affect your ability to concentrate and remember. lead is especially dangerous for children. a child who swallows large amounts of lead may develop anemia, severe stomachache, muscle weakness, and brain damage. even at low levels, lead can affect a child's mental and physical growth. agency for toxic substances disease registry

MalaCards: Lead Poisoning, also known as lead intoxication, is related to asthma and acute intermittent porphyria. An important gene associated with Lead Poisoning is ALAD (aminolevulinate dehydratase), and among its related pathways are Amino acid synthesis and interconversion (transamination) and Vitamin D2 (ergocalciferol) metabolism. The compounds alpha tocopherol and gssg have been mentioned in the context of this disorder. Affiliated tissues include whole blood, brain and spinal cord, and related mouse phenotypes are mortality/aging and homeostasis/metabolism.

CDC:3 Today at least 4 million households have children living in them that are being exposed to high levels of lead. There are approximately half a million U.S. children ages 1-5 with blood lead levels above 5 micrograms per deciliter (µg/dL), the reference level at which CDC recommends public health actions be initiated.

Wikipedia:64 Lead poisoning (also known as plumbism, colica pictorum, saturnism, Devon colic, or painter\'s colic) is... more...

Description from OMIM:47 612740

Aliases & Classifications for Lead Poisoning

Sources:
47OMIM, 49Orphanet, 34MedlinePlus, 26ICD10 via Orphanet
See all sources

Classifications:



Characteristics (Orphanet epidemiological data):

49
lead poisoning:
Prevalence: 1-9/100000; Age of onset: Childhood


Aliases & Descriptions:

lead poisoning 47 49 34
lead intoxication 49
saturnism 49


External Ids:

ICD10 via Orphanet26 T56.0

Related Diseases for Lead Poisoning

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Lead Poisoning via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 165)
idRelated DiseaseScoreTop Affiliating Genes
1asthma30.3NGF, VDR
2acute intermittent porphyria30.2SOD1, ALAD
3iron deficiency anemia30.0G6PD, HFE
4deficiency anemia30.0G6PD, HFE, ALAD, ALB
5infertility30.0CAT
6hereditary spherocytosis30.0HFE, G6PD
7amyotrophic lateral sclerosis30.0ALAD, GLUD1, NGF, SOD1
8acute porphyria10.2
9erythropoietic protoporphyria10.2
10aminoaciduria10.2
11myeloperoxidase deficiency10.0
12hypoxia10.0
13gout10.0
14lateral sclerosis10.0
15osteonecrosis10.0
16thrombocytosis10.0
17fanconi syndrome10.0
18landau-kleffner syndrome10.0
19intestinal volvulus10.0
20eosinophilic meningitis10.0
21arthropathy10.0
22developmental disabilities10.0
23hypoaldosteronism10.0
24guillain-barr� syndrome10.0
25autonomic dysfunction10.0
26hypotonia10.0
27anemia, hemolytic, due to umph1 deficiency10.0
28sarcoidosis10.0CYP27B1
29myocardial infarction10.0HFE
30celiac disease10.0HFE
31variegate porphyria10.0ALAD
32hypervitaminosis d10.0CYP27B1
33sickle cell disease10.0G6PD
34neuroblastoma10.0NGF
35thromboembolism10.0G6PD
36congenital hypothyroidism10.0G6PD
37diabetic polyneuropathy10.0NGF
38favism10.0G6PD
39lung cancer10.0ALB
40peritonitis10.0ALB
41hemosiderosis10.0HFE
42acute myocardial infarction10.0CAT
43prostatitis10.0VDR
44pyruvate kinase deficiency10.0G6PD
45pheochromocytoma10.0NGF
46diarrhea10.0ALB
47cystic fibrosis10.0ALB
48goiter10.0CAT
49esophagitis10.0CAT
50choriocarcinoma10.0VDR

Graphical network of the top 20 diseases related to Lead Poisoning:



Diseases related to lead poisoning

Clinical Features for Lead Poisoning

Sources:
47OMIM
See all sources

Clinical features from OMIM:

612740

Drugs & Therapeutics for Lead Poisoning

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Lead Poisoning

Drug clinical trials:

Search ClinicalTrials for Lead Poisoning

Search NIH Clinical Center for Lead Poisoning

Search CenterWatch for Lead Poisoning

Genetic Tests for Lead Poisoning

Anatomical Context for Lead Poisoning

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Lead Poisoning:

33
Whole blood, Brain, Spinal cord, Heart, Kidney, Liver, Skin, Fetal brain, Tongue, Fetal liver

Animal Models for Lead Poisoning or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Lead Poisoning:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107686.4SOD1, G6PD, HFE, VDR, NGF, GGT1
2MP:00053765.5ALB, CAT, SOD1, G6PD, HFE, VDR

Publications for Lead Poisoning

Sources:
51PubMed
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Articles related to Lead Poisoning:

(show top 50)    (show all 518)
idTitleAuthorsYear
1
Are local laws the key to ending childhood lead poisoning? (23645870)
2013
2
What role does nutrition play in the prevention or treatment of childhood lead poisoning? (23102188)
2012
3
Characterizing N-acetylcysteine (NAC) and N-acetylcysteine amide (NACA) binding for lead poisoning treatment. (22284448)
2012
4
Infant lead poisoning associated with use of tiro, an eye cosmetic from Nigeria--Boston, Massachusetts, 2011. (22854626)
2012
5
Chinese children with lead poisoning are denied treatment. (21685441)
2011
6
Comparing lead poisoning risk assessment methods: census block group characteristics vs. zip codes as predictors. (20297750)
2010
7
Information from your family doctor. Lead poisoning in children. (20329339)
2010
8
A comparison of sodium calcium edetate (edetate calcium disodium) and succimer (DMSA) in the treatment of inorganic lead poisoning. (19852620)
2009
9
Evaluation and treatment of wrist drop in a patient due to lead poisoning: case report. (19996545)
2009
10
Lead poisoning cases spark riots in China. (19757511)
2009
11
Lead poisoning as possible cause of deaths at the Swedish House at Kapp Thordsen, Spitsbergen, winter 1872-3. (19965937)
2009
12
Long-term effects of lead poisoning on bone mineralization in vultures exposed to ammunition sources. (18995938)
2009
13
Benjamin Franklin's risk factors for gout and stones: from genes and diet to possible lead poisoning. (19244863)
2008
14
Environmental injustice: childhood lead poisoning, teen pregnancy, and tobacco. (18155029)
2008
15
Monetary benefits of preventing childhood lead poisoning with lead-safe window replacement. (17961540)
2008
16
The effect of lead poisoning on hematologic and biochemical values in trumpeter swans and Canada geese. (18041699)
2007
17
Childhood lead poisoning prevention activities within Michigan local public health departments. (17236613)
2007
18
The conquest of lead poisoning: a Pyrrhic victory. (17938707)
2007
19
Anaemia and abdominal pain due to occupational lead poisoning. (17405745)
2007
20
Needs assessment and intervention strategies to reduce lead-poisoning risk among low-income Ohio toddlers. (16460421)
2006
21
Effects of short-term and subchronic lead poisoning on nitric oxide metabolites and vascular responsiveness in rat. (16860498)
2006
22
Control of lead poisoning in Pakistan. (16304844)
2005
23
Improving strategies to prevent childhood lead poisoning using local data. (15881974)
2005
24
Lead poisoning from a toy necklace. (16199723)
2005
25
Lead poisoning in cattle grazing pasture contaminated by industrial waste. (15587252)
2004
26
Lead poisoning associated with ayurvedic medications--five states, 2000-2003. (15241300)
2004
27
From research to policy: Targeting the primary prevention of childhood lead poisoning. (15158106)
2004
28
A videotape to improve parental knowledge of lead poisoning. (15264949)
2004
29
Recommendations from lead poisoning prevention program participants: best practices. (15358915)
2004
30
A medical mystery. Lead poisoning. (15455173)
2004
31
Environmental lead exposure in Polish children: blood lead levels, major sources and principles of the lead poisoning prevention. (18365064)
2003
32
Acute pediatric lead poisoning: combined whole bowel irrigation, succimer therapy, and endoscopic removal of ingested lead pellets. (12066009)
2002
33
A molecular epidemiological study of childhood lead poisoning in lead-polluted environment]. (12411083)
2002
34
Pre-1950s housing in Tennessee counties puts children at risk for lead poisoning. (12369544)
2002
35
Lead poisoning in Indian silver refiners. (11778950)
2001
36
Lead poisoning and chelation in a mother-neonate pair. (11778671)
2001
37
Lead poisoning in a historical perspective. (10940962)
2000
38
A presumptive case of lead poisoning in a brass-worker's child. (11294328)
2000
39
Biomedical communication and the reaction to the Queensland childhood lead poisoning cases elsewhere in the world. (10885137)
1999
40
The effects of lead poisoning on expression of nerve growth factor gene of submandibular gland in mice]. (11864487)
1999
41
Clinician follow-up of children screened for lead poisoning. (10394321)
1999
42
Lead poisoning in woodpeckers in Sweden. (10574536)
1999
43
Hidden threats: lead poisoning from unusual sources. (10545579)
1999
44
In the air that they breathe. Lead poisoning remains a major health hazard for America's children. (10724814)
1999
45
Preventing childhood lead poisoning: the challenge of change. (9566943)
1998
46
Preventing lead poisoning and its consequences. (9849268)
1998
47
Comparison of dimercaptosuccinic acid and calcium disodium ethylenediaminetetraacetic acid versus dimercaptopropanol and ethylenediaminetetraacetic acid in children with lead poisoning. (9202621)
1997
48
Determination of the activity of delta-aminolevulinic acid dehydratase--a method for the diagnosis of lead poisoning in birds]. (7940512)
1994
49
Reassessment of the microcytic anemia of lead poisoning. (7232054)
1981
50
Gluco-phospho-amine diabetes (Debre-DeToni-Fanconi syndrome) associated with subacute lead poisoning. (14493547)
1962

Genetic Variations for Lead Poisoning

Expression for genes affiliated with Lead Poisoning

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Lead Poisoning

Search GEO for disease gene expression data for Lead Poisoning.

Pathways for genes affiliated with Lead Poisoning

Sources:
54Reactome, 38NCBI BioSystems Database, 12EMD Millipore, 50PharmGKB, 4Cell Signaling Technology
See all sources

Compounds for genes affiliated with Lead Poisoning

Sources:
45Novoseek, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Lead Poisoning according to GeneCards/GeneDecks:

(show top 50)    (show all 146)
idCompoundScoreTop Affiliating Genes
1alpha tocopherol4510.5G6PD
2gssg4510.5G6PD
3dehydroascorbic acid45 1110.9G6PD, CAT
4dmsa459.8G6PD, VDR, ALAD
5uroporphyrin459.8ALAD, GGT1, HFE
6zinc protoporphyrin459.7G6PD, ALAD, VDR
7nadph45 2410.7CYP27B1, GLUD1, G6PD
85-aminolevulinic acid45 2410.7HFE, ALAD, VDR
9vitamin a45 11 2411.6CYP27B1, VDR, CAT
10uric acid45 2410.6G6PD, HFE, GLUD1, ALAD
11nickel carbonate hydroxide459.6CAT, SOD1
12fpl 55712459.5CAT, SOD1
13bathocuproine459.5SOD1, CAT
14u 83836e459.5SOD1, CAT
15thiobarbituric acid459.3G6PD, CAT, SOD1
16sodium azide459.3SOD1, CAT, G6PD
173-amino-1,2,4-triazole459.3SOD1, NGF, CAT
18tocopherol459.2SOD1, G6PD, CAT
19selegiline45 1110.2SOD1, CAT, NGF
20copper45 2410.1ALAD, SOD1, CAT
21mannitol45 1110.1CAT, ALB, GGT1
22glucose 6-phosphate45 2410.0GLUD1, SOD1, CAT, G6PD
23formate459.0CAT, SOD1, G6PD
24hypoxanthine45 11 2410.9NGF, G6PD, CAT, SOD1
25vitamin b12458.9ALB, G6PD, GGT1, ALAD
26glutaraldehyde458.9G6PD, GLUD1, ALB
27dtpa458.8ALB, CAT, SOD1
28phosphorus458.8GGT1, CYP27B1, ALB, VDR
29vitamin-e458.8CAT, SOD1, G6PD, GGT1
30betacarotene458.7GGT1, SOD1, VDR, CAT
31salicylic acid45 299.7ALB, VDR, CAT, G6PD
32heme29 11 2410.6ALB, CAT, ALAD, HFE, CYP27B1
33malondialdehyde458.6GGT1, ALAD, G6PD, SOD1, CAT
34vitamin d458.5ALAD, ALB, CYP27B1, NGF, VDR
35aspartate458.5HFE, GLUD1, ALB, G6PD, VDR
36quercetin45 60 11 2411.5CAT, SOD1, NGF, GGT1
37diethyl dithiocarbamate458.5CAT, SOD1, GGT1
38alpha lipoic acid458.5NGF, G6PD, SOD1, CAT, GGT1
39citrate458.4ALB, GLUD1, VDR, G6PD, CAT
40glutamine458.4NGF, VDR, G6PD, GLUD1, GGT1
41thyroxine45 249.3G6PD, VDR, NGF, GGT1, ALB
42indomethacin45 60 29 1110.9CAT, SOD1, NGF, GGT1, ALB
43iron45 248.8SOD1, ALAD, GGT1, HFE, ALB, CAT
44creatinine457.5GGT1, SOD1, ALB, ALAD, VDR, NGF
45lactate457.5ALB, ALAD, GGT1, GLUD1, G6PD, SOD1
46testosterone45 60 11 2410.4CYP27B1, NGF, VDR, HFE, G6PD, GGT1
47alanine457.4SOD1, ALB, GGT1, GLUD1, NGF, HFE
48lipid457.1G6PD, CAT, SOD1, HFE, CYP27B1, GGT1
49ascorbic acid45 248.0GGT1, ALAD, VDR, HFE, ALB, CAT
50cysteine456.6GGT1, NGF, CAT, SOD1, HFE, VDR

GO Terms for genes affiliated with Lead Poisoning

Sources:
16Gene Ontology
See all sources

Biological processes related to Lead Poisoning according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vitamin D 24-hydroxylase activityGO:0109809.8VDR, CYP27B1
2positive regulation of keratinocyte differentiationGO:0456189.8VDR, CYP27B1
3decidualizationGO:0466979.6CYP27B1, VDR
4cellular amino acid biosynthetic processGO:0086529.6GLUD1, PSPH
5response to nutrient levelsGO:0316679.6PSPH, SOD1
6glutathione metabolic processGO:0067499.1GGT1, G6PD, SOD1
7response to organic substanceGO:0100339.0ALB, SOD1
8small molecule metabolic processGO:0442817.2ALB, CAT, PSPH, G6PD, GLUD1, CYP27B1

Molecular functions related to Lead Poisoning according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1antioxidant activityGO:0162099.1ALB, CAT

Products for genes affiliated with Lead Poisoning

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  • Lysates
  • Antibodies

Sources for Lead Poisoning

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet