MCID: LDP002
MIFTS: 43

Lead Poisoning malady

Summaries for Lead Poisoning

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33MedlinePlus, 3CDC, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Lead is a metal that occurs naturally in the earth's crust. lead can be found in all parts of our environment. much of it comes from human activities such as mining and manufacturing. lead used to be in paint; older houses may still have lead paint. you could be exposed to lead by eating food or drinking water that contains lead. water pipes in older homes may contain lead. working in a job where lead is used using lead in a hobby, such as making stained glass or lead-glazed pottery using folk remedies such as herbs or foods that contain lead breathing air, drinking water, eating food, or swallowing or touching dirt that contains lead can cause many health problems. lead can affect almost every organ and system in your body. in adults, lead can increase blood pressure and cause infertility, nerve disorders, and muscle and joint pain. it can also make you irritable and affect your ability to concentrate and remember. lead is especially dangerous for children. a child who swallows large amounts of lead may develop anemia, severe stomachache, muscle weakness, and brain damage. even at low levels, lead can affect a child's mental and physical growth. agency for toxic substances disease registry

MalaCards: Lead Poisoning, also known as lead intoxication, is related to porphyria and asthma. An important gene associated with Lead Poisoning is ALAD (aminolevulinate dehydratase), and among its related pathways are Amino acid synthesis and interconversion (transamination) and Vitamin D2 (ergocalciferol) metabolism. The compounds alpha tocopherol and gssg have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and heart, and related mouse phenotypes are mortality/aging and homeostasis/metabolism.

CDC:3 Today at least 4 million households have children living in them that are being exposed to high levels of lead. There are approximately half a million U.S. children ages 1-5 with blood lead levels above 5 micrograms per deciliter (µg/dL), the reference level at which CDC recommends public health actions be initiated.

Wikipedia:63 Lead poisoning (also known as plumbism, colica pictorum, saturnism, Devon colic, or painter\'s colic) is... more...

Description from OMIM:46 612740

Aliases & Classifications for Lead Poisoning

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46OMIM, 48Orphanet, 33MedlinePlus, 26ICD10 via Orphanet
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Classifications:



Characteristics (Orphanet epidemiological data):

48
lead poisoning:
Prevalence: 1-9/100000; Age of onset: Childhood


Aliases & Descriptions:

lead poisoning 46 48 33
lead intoxication 48
saturnism 48


External Ids:

ICD10 via Orphanet26 T56.0

Related Diseases for Lead Poisoning

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17GeneCards, 18GeneDecks
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Diseases related to Lead Poisoning via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 170)
idRelated DiseaseScoreTop Affiliating Genes
1porphyria30.4ALAD, HFE
2asthma30.3NGF, VDR
3acute intermittent porphyria30.1SOD1, ALAD
4hepatitis30.1HFE, GLUD1, GGT1, ALB
5multiple sclerosis30.1VDR, NGF, GLUD1, CYP27B1, ALB
6iron deficiency anemia30.0G6PD, HFE
7deficiency anemia29.9G6PD, HFE, ALAD, ALB
8infertility29.9CAT
9microcytic anemia29.9G6PD
10hereditary spherocytosis29.9HFE, G6PD
11neuropathy29.9ALB, NGF
12hypertension29.9ALB, GGT1
13meningitis29.9ALB, CAT
14malaria29.9G6PD, GLUD1, ALAD, ALB
15amyotrophic lateral sclerosis29.9ALAD, GLUD1, NGF, SOD1
16acute porphyria10.2
17erythropoietic protoporphyria10.1
18constipation10.1
19metaphyseal dysplasia10.1
20renal cell carcinoma10.0
21laryngitis10.0
22periodontal disease10.0
23periodontitis10.0
24sarcoidosis10.0CYP27B1
25myocardial infarction10.0HFE
26celiac disease10.0HFE
27variegate porphyria10.0ALAD
28hypervitaminosis d10.0CYP27B1
29sickle cell disease10.0G6PD
30neuroblastoma10.0NGF
31thromboembolism10.0G6PD
32congenital hypothyroidism10.0G6PD
33diabetic polyneuropathy10.0NGF
34favism10.0G6PD
35lung cancer10.0ALB
36peritonitis10.0ALB
37hemosiderosis10.0HFE
38prostatitis10.0VDR
39acute myocardial infarction10.0CAT
40pyruvate kinase deficiency10.0G6PD
41pheochromocytoma10.0NGF
42diarrhea10.0ALB
43cystic fibrosis10.0ALB
44goiter10.0CAT
45esophagitis10.0CAT
46choriocarcinoma10.0VDR
47myeloma10.0ALB
48vasculitis10.0ALB
49prion disease10.0CAT
50alcohol dependence10.0GGT1

Graphical network of the top 20 diseases related to Lead Poisoning:



Diseases related to lead poisoning

Clinical Features for Lead Poisoning

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46OMIM
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Clinical features from OMIM:

612740

Drugs & Therapeutics for Lead Poisoning

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Lead Poisoning

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Anatomical Context for Lead Poisoning

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32MalaCards
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MalaCards organs/tissues related to Lead Poisoning:

32
Bone, Brain, Heart, Kidney

Animal Models for Lead Poisoning or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Lead Poisoning:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107686.4SOD1, G6PD, HFE, VDR, NGF, GGT1
2MP:00053765.5ALB, CAT, SOD1, G6PD, HFE, VDR

Publications for Lead Poisoning

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Genetic Variations for Lead Poisoning

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Lead Poisoning:

62
id Symbol AA change Variation ID SNP ID
1ALADp.Gly133ArgVAR_003634
2ALADp.Arg240TrpVAR_003635
3ALADp.Ala274ThrVAR_003636
4ALADp.Val275MetVAR_003637
5ALADp.Val153MetVAR_020974

Expression for genes affiliated with Lead Poisoning

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lead Poisoning

Search GEO for disease gene expression data for Lead Poisoning.

Pathways for genes affiliated with Lead Poisoning

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Sources:
53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 49PharmGKB, 4Cell Signaling Technology
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Compounds for genes affiliated with Lead Poisoning

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44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Lead Poisoning according to GeneCards/GeneDecks:

(show top 50)    (show all 146)
idCompoundScoreTop Affiliating Genes
1alpha tocopherol4410.5G6PD
2gssg4410.5G6PD
3dehydroascorbic acid44 1110.9G6PD, CAT
4dmsa449.8G6PD, VDR, ALAD
5uroporphyrin449.8ALAD, GGT1, HFE
6zinc protoporphyrin449.7G6PD, ALAD, VDR
7nadph44 2410.7CYP27B1, GLUD1, G6PD
85-aminolevulinic acid44 2410.7HFE, ALAD, VDR
9vitamin a44 11 2411.6CYP27B1, VDR, CAT
10uric acid44 2410.6G6PD, HFE, GLUD1, ALAD
11nickel carbonate hydroxide449.6CAT, SOD1
12fpl 55712449.5CAT, SOD1
13bathocuproine449.5SOD1, CAT
14u 83836e449.5SOD1, CAT
15thiobarbituric acid449.3G6PD, CAT, SOD1
16sodium azide449.3SOD1, CAT, G6PD
173-amino-1,2,4-triazole449.3SOD1, NGF, CAT
18tocopherol449.2SOD1, G6PD, CAT
19selegiline44 1110.2SOD1, CAT, NGF
20copper44 2410.1ALAD, SOD1, CAT
21mannitol44 1110.1CAT, ALB, GGT1
22glucose 6-phosphate44 2410.0GLUD1, SOD1, CAT, G6PD
23formate449.0CAT, SOD1, G6PD
24hypoxanthine44 11 2410.9NGF, G6PD, CAT, SOD1
25vitamin b12448.9ALB, G6PD, GGT1, ALAD
26glutaraldehyde448.9G6PD, GLUD1, ALB
27dtpa448.8ALB, CAT, SOD1
28phosphorus448.8GGT1, CYP27B1, ALB, VDR
29vitamin-e448.8CAT, SOD1, G6PD, GGT1
30betacarotene448.7GGT1, SOD1, VDR, CAT
31salicylic acid44 289.7ALB, VDR, CAT, G6PD
32heme28 11 2410.6ALB, CAT, ALAD, HFE, CYP27B1
33malondialdehyde448.6GGT1, ALAD, G6PD, SOD1, CAT
34vitamin d448.5ALAD, ALB, CYP27B1, NGF, VDR
35aspartate448.5HFE, GLUD1, ALB, G6PD, VDR
36quercetin44 59 11 2411.5CAT, SOD1, NGF, GGT1
37diethyl dithiocarbamate448.5CAT, SOD1, GGT1
38alpha lipoic acid448.5NGF, G6PD, SOD1, CAT, GGT1
39citrate448.4ALB, GLUD1, VDR, G6PD, CAT
40glutamine448.4NGF, VDR, G6PD, GLUD1, GGT1
41thyroxine44 249.3G6PD, VDR, NGF, GGT1, ALB
42indomethacin44 59 28 1110.9CAT, SOD1, NGF, GGT1, ALB
43iron44 248.8SOD1, ALAD, GGT1, HFE, ALB, CAT
44creatinine447.5GGT1, SOD1, ALB, ALAD, VDR, NGF
45lactate447.5ALB, ALAD, GGT1, GLUD1, G6PD, SOD1
46testosterone44 59 11 2410.4CYP27B1, NGF, VDR, HFE, G6PD, GGT1
47alanine447.4SOD1, ALB, GGT1, GLUD1, NGF, HFE
48lipid447.1G6PD, CAT, SOD1, HFE, CYP27B1, GGT1
49ascorbic acid44 248.0GGT1, ALAD, VDR, HFE, ALB, CAT
50cysteine446.6GGT1, NGF, CAT, SOD1, HFE, VDR

GO Terms for genes affiliated with Lead Poisoning

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16Gene Ontology
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Biological processes related to Lead Poisoning according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vitamin D 24-hydroxylase activityGO:0109809.8VDR, CYP27B1
2positive regulation of keratinocyte differentiationGO:0456189.8CYP27B1, VDR
3decidualizationGO:0466979.6VDR, CYP27B1
4cellular amino acid biosynthetic processGO:0086529.6PSPH, GLUD1
5response to nutrient levelsGO:0316679.6PSPH, SOD1
6glutathione metabolic processGO:0067499.1GGT1, G6PD, SOD1
7response to organic substanceGO:0100339.0ALB, SOD1
8small molecule metabolic processGO:0442817.2ALB, CAT, PSPH, G6PD, GLUD1, CYP27B1

Molecular functions related to Lead Poisoning according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1antioxidant activityGO:0162099.1ALB, CAT

Products for genes affiliated with Lead Poisoning

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Sources for Lead Poisoning

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet