MCID: LRN003
MIFTS: 63

Learning Disability malady

Fetal diseases category
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Summaries for Learning Disability

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MedlinePlus:33 Learning disorders affect how a person understands, remembers and responds to new information. people with learning disorders may have problems listening or paying attention speaking reading or writing doing math although learning disorders occur in very young children, they are usually not recognized until the child reaches school age. about one-third of children who have learning disabilities also have adhd, which makes it hard to focus. evaluation and testing by a trained professional can help identify a learning disorder. the next step is special education, which involves helping your child in the areas where he or she needs the most help. sometimes tutors or speech or language therapists also work with the children. learning disorders do not go away, but strategies to work around them can make them less of a problem. nih: national institute of neurological disorders and stroke

MalaCards based summary: Learning Disability, also known as learning disorders, is related to neurofibromatosis and tuberous sclerosis. An important gene associated with Learning Disability is OMG (oligodendrocyte myelin glycoprotein), and among its related pathways are Neuroscience and Glioma. The compounds gelfoam and tecogalan sodium have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and heart, and related mouse phenotypes are hearing/vestibular/ear and liver/biliary system.

Disease Ontology:8 A specific developmental disorder that involves difficulty in scholastic skills such as reading, writing, spelling, reasoning, recalling and/or organizing information resulting from the brain's inability to receive and process information.

NINDS:43 Learning disabilities are disorders that affect the ability to understand or use spoken or written language, do mathematical calculations, coordinate movements, or direct attention. Although learning disabilities occur in very young children, the disorders are usually not recognized until the child reaches school age. Research shows that 8 to 10 percent of American children under 18 years of age have some type of learning disability.

Wikipedia:65 Learning disability is a classification including several areas of functioning in which a person has... more...

Aliases & Classifications for Learning Disability

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Learning Disability, Aliases & Descriptions:

Name: Learning Disability 8 22 10
Learning Disorders 65 44 33 62
Academic Skill Disorder 8 62
 
Learning Disabilities 43 62
Learning Disorder 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases


External Ids:

Disease Ontology8 DOID:8927
MeSH34 D007859

Related Diseases for Learning Disability

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Diseases related to Learning Disability via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1050)
idRelated DiseaseScoreTop Affiliating Genes
1neurofibromatosis30.6NF1, OMG
2tuberous sclerosis30.4TSC1, MECP2, NF1
3mental retardation30.4NF1, MAPT, MECP2, TSC1
4autistic disorder30.2CDH8, MECP2, TSC1
5niemann-pick disease type c130.1PSAP, MAPT
6moyamoya disease30.0NF1, FGF2
7hydrocephalus29.9TSC1, MAPT, NF1
8ischemia29.7PF4, PSAP, CNTF, MAPT, FGF2
9breast cancer28.8MYCN, TSC1, PSAP, MECP2, MAPT, NF1
10attention deficit hyperactivity disorder10.5
113mc syndrome 110.5MASP1
12schizophrenia10.5
13fragile x syndrome10.4
14dyslexia10.4
15ganglioglioma10.4TSC1
16cervicitis10.4
17adrenal neuroblastoma10.3PHOX2B, MYCN
18asperger syndrome10.3
19turner syndrome10.3
20epilepsy, x-linked, with variable learning disabilities and behavior disorders10.3
21infantile epileptic encephalopathy10.3TSC1, MECP2
22dyscalculia10.3
23brain injury10.2
24obesity10.2
25traumatic brain injury10.2
26sotos syndrome10.2
27neuronitis10.2
28autism spectrum disorder10.2
29personality disorder10.2
30intermittent claudication10.2PF4, FGF2
31corneal neovascularization10.2FGF2, PF4
32intellectual disability multi-gene panels10.2MECP2, TSC1, PTCHD1
33weaver syndrome10.2
34dysgraphia10.2
35incontinentia pigmenti achromians10.2
36methylmalonic acidemia10.2
37goldberg-shprintzen megacolon syndrome10.2
38schindler disease, type 110.2
39shprintzen omphalocele syndrome10.2
40thanatophoric dysplasia type 110.2
41hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia10.2
42pilocytic astrocytoma10.1NF1, TSC1
43malaria10.1MAPT, CNTF
44cervical cancer10.1
45crigler-najjar syndrome10.1
46phenylketonuria10.1
47bloom syndrome10.1
48klippel-trenaunay syndrome10.1
49landau-kleffner syndrome10.1
50silver-russell syndrome10.1

Graphical network of the top 20 diseases related to Learning Disability:



Diseases related to learning disability

Symptoms for Learning Disability

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Drugs & Therapeutics for Learning Disability

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Drug clinical trials:

Search ClinicalTrials for Learning Disability

Search NIH Clinical Center for Learning Disability

Genetic Tests for Learning Disability

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Genetic tests related to Learning Disability:

id Genetic test Affiliating Genes
1 Learning Disability22

Anatomical Context for Learning Disability

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MalaCards organs/tissues related to Learning Disability:

32
Testes, Brain, Heart, Breast, Eye, Bone

Animal Models for Learning Disability or affiliated genes

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Publications for Learning Disability

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Articles related to Learning Disability:

(show top 50)    (show all 551)
idTitleAuthorsYear
1
Cognitive Profiles of Mathematical Problem Solving Learning Disability for Different Definitions of Disability. (24939971)
2014
2
'It's One of the Hardest Jobs in the World': The Experience and Understanding of Qualified Nurses Who Work with Individuals Diagnosed with Both Learning Disability and Personality Disorder. (25196279)
2014
3
Managing eating and drinking difficulties (dysphagia) with children who have learning disabilities: What is effective? (24414040)
2014
4
Knowledge exchange and integrated services: experiences from an integrated community intellectual (learning) disability service for adults. (24762266)
2014
5
Limited knowledge of fraction representations differentiates middle school students with mathematics learning disability (dyscalculia) versus low mathematics achievement. (23587941)
2013
6
Handedness and language learning disability differentially distribute in progressive aphasia variants. (24056533)
2013
7
Methylphenidate treatment of attention deficit hyperactivity disorder in young people with learning disability and difficult-to-treat epilepsy: Evidence of clinical benefit. (24304474)
2013
8
Estimating the severity of intellectual disability in adults: a Mokken scaling analysis of the learning disability screening questionnaire. (23544397)
2013
9
Mathematical difficulties in nonverbal learning disability or co-morbid dyscalculia and dyslexia. (23971493)
2013
10
Exemplar variability facilitates rapid learning of an otherwise unlearnable grammar by individuals with language-based learning disability. (22988285)
2013
11
End of life care for people with a learning disability. (23082363)
2012
12
Identity, emotion and the internal goods of practice: a study of learning disability professionals. (21668456)
2012
13
Use and abuse of specific learning disability certificates. (23271859)
2011
14
POMHS 9b - antipsychotic prescribing in people with a learning disability. (21894103)
2011
15
A novel mutation in the HSD17B10 gene of a 10-year-old boy with refractory epilepsy, choreoathetosis and learning disability. (22132097)
2011
16
Improving recording of capacity to consent and explanation of medication side effects in a psychiatric service for people with learning disability: audit findings. (21750211)
2011
17
'It terrifies me, the thought of the future': listening to the current concerns of informal carers of people with a learning disability. (20630924)
2010
18
Processing prosodic structure by adults with language-based learning disability. (19324365)
2009
19
4.5 Mb microdeletion in chromosome band 2q33.1 associated with learning disability and cleft palate. (19576302)
2009
20
A review of mathematical learning disabilities in children with fragile X syndrome. (19213014)
2009
21
Drawing on three discursive modes in learning disability nurse education. (18829142)
2009
22
Dental Discomfort Questionnaire: its use with children with a learning disability. (18647374)
2008
23
Learning disability and the limits of liberal citizenship: interactional impediments to political empowerment. (17714342)
2007
24
Bilateral periventricular nodular heterotopia, severe learning disability, and epilepsy in a male patient with 46,XY,der(19)t(X;19) (q11.1-11.2;p13.3). (17355480)
2007
25
Mathematics learning disability in girls with Turner syndrome or fragile X syndrome. (16500739)
2006
26
Disruption of a brain transcription factor, NPAS3, is associated with schizophrenia and learning disability. (15924306)
2005
27
Needs assessment in forensic learning disability. (15895641)
2005
28
Taurodontism and learning disabilities in patients with Klinefelter syndrome. (16435639)
2005
29
Improving primary care services for people with learning disability. (15658237)
2005
30
Forensic issues in learning disability. (16575790)
2004
31
Microarray based comparative genomic hybridisation (array-CGH) detects submicroscopic chromosomal deletions and duplications in patients with learning disability/mental retardation and dysmorphic features. (15060094)
2004
32
Autism and learning disability. (15165430)
2004
33
Making sense in a fragmentary world: communication in people with autism and learning disability. (15165435)
2004
34
Fine motor deficiencies in children with developmental coordination disorder and learning disabilities: an underlying open-loop control deficit. (14624830)
2003
35
Prevention in severe learning disability: lessons from a follow-up study of young adults with a history of childhood learning disability. (12898990)
2003
36
Interprofessional practice and learning disability nursing. (14688655)
2003
37
Quality of life as a concept for developing learning disability nursing practice? (12519251)
2003
38
Learning disability task force criticises draft mental health bill. (12549435)
2003
39
Adult outcome of childhood learning disability. (11570634)
2001
40
How does the severity of a learning disability affect working memory performance? (11594349)
2001
41
Behaviour modification and gentle teaching workshops: management of children with learning disabilities exhibiting challenging behaviour and implications for learning disability nursing. (11430611)
2001
42
An evaluation of community learning disability services for children with a learning disability. (12664722)
2001
43
Nurse networks in learning disability. (11968667)
2000
44
What definitions of learning disability say and don't say: a critical analysis. (15505963)
2000
45
Numerical and arithmetical cognition: a longitudinal study of process and concept deficits in children with learning disability. (11023658)
2000
46
Psychiatric illness and behavioural problems in adults with learning disability and epilepsy. (22387591)
1999
47
Assessing the ability of people with a learning disability to give informed consent to treatment. (10616942)
1999
48
Learning disability nursing. (10661193)
1999
49
Violence faced by staff in a learning disability service. (9548019)
1998
50
Learning disability and epilepsy. 2, a review of available outcome measures and position statement on development priorities. (9663797)
1997

Variations for Learning Disability

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Expression for genes affiliated with Learning Disability

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Expression patterns in normal tissues for genes affiliated with Learning Disability

Search GEO for disease gene expression data for Learning Disability.

Pathways for genes affiliated with Learning Disability

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Pathways related to Learning Disability according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8MAPT, MECP2
2
Show member pathways
Signaling Pathways in Glioblastoma37
9.3FGF2, NF1, TSC1
3
Show member pathways
9.1FGF2, CDH8, MAPT, TSC1
4
Show member pathways
8.4PF4, TSC1, NF1, CDH8, FGF2

Compounds for genes affiliated with Learning Disability

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Compounds related to Learning Disability according to GeneCards/GeneDecks:

(show all 27)
idCompoundScoreTop Affiliating Genes
1gelfoam4410.0MAPT, FGF2
2tecogalan sodium449.9FGF2, PF4
3protamine sulfate449.8PF4, FGF2
4bromodeoxyuridine449.8FGF2, CNTF, MYCN
5ganglioside449.8CNTF, PSAP, PF4
6guanosine44 24 1111.8TSC1, MECP2, NF1
7choline44 24 1111.7PSAP, CNTF, MAPT
8actinomycin d449.4MYCN, CNTF, MAPT, FGF2
9genistein44 28 61 2 24 1114.4FGF2, MAPT, CNTF, MYCN
10cytochalasin d44 6110.4FGF2, NF1, MAPT
11methionine449.4NF1, MAPT, CNTF, MECP2
12testosterone44 61 24 1112.3MAPT, CNTF, MECP2, PSAP
13heparan sulfate44 2410.3PF4, MAPT, FGF2
14nicotine44 28 50 1112.2PF4, MAPT, FGF2
15phosphatidylinositol449.1TSC1, PSAP, CNTF, NF1, FGF2
16nacl449.1NF1, MAPT, PSAP, PF4
17vegf449.1FGF2, CNTF, TSC1, MYCN, PF4
18cycloheximide449.1FGF2, MAPT, CNTF, MYCN
19agar449.0PF4, MYCN, FGF2
20paraffin448.9MYCN, TSC1, MAPT, NF1, FGF2
21glucose448.8MAPT, CNTF, PSAP, TSC1, PF4
22retinoic acid44 249.8FGF2, NF1, MAPT, CNTF, MYCN
23dopamine44 28 24 1111.6PF4, MYCN, CNTF, MAPT, NF1, PHOX2B
24arginine448.6PF4, PSAP, MECP2, CNTF, MAPT, NF1
25serine448.1MYCN, TSC1, PSAP, CNTF, MAPT, MASP1
26tyrosine448.1PF4, MYCN, TSC1, PSAP, CNTF, NF1
27alanine448.1FGF2, PF4, TSC1, MECP2, CNTF, MAPT

GO Terms for genes affiliated with Learning Disability

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Cellular components related to Learning Disability according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.5FGF2, MASP1, CNTF, MECP2, PSAP, PF4

Biological processes related to Learning Disability according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1regulation of retinal cell programmed cell deathGO:04666810.1FGF2, CNTF
2regulation of respiratory gaseous exchange by neurological system processGO:00208710.1MECP2, PHOX2B
3startle responseGO:0019649.9NPAS3, MECP2
4glial cell differentiationGO:0100019.9FGF2, PHOX2B
5regulation of cell-matrix adhesionGO:0019529.9NF1, TSC1
6negative regulation of astrocyte differentiationGO:0487129.7NF1, MYCN
7sympathetic nervous system developmentGO:0484859.7PHOX2B, NF1
8cognitionGO:0508909.6NF1, PTCHD1
9regulation of angiogenesisGO:0457659.3FGF2, NF1

Products for genes affiliated with Learning Disability

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  • Antibodies
  • Proteins
  • Lysates

Sources for Learning Disability

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet