MCID: LRN003
MIFTS: 58

Learning Disability malady

Summaries for Learning Disability

About this section
Sources:
8Disease Ontology, 33MedlinePlus, 43NINDS, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:33 Learning disorders affect how a person understands, remembers and responds to new information. people with learning disorders may have problems listening or paying attention speaking reading or writing doing math although learning disorders occur in very young children, they are usually not recognized until the child reaches school age. about one-third of children who have learning disabilities also have adhd, which makes it hard to focus. evaluation and testing by a trained professional can help identify a learning disorder. the next step is special education, which involves helping your child in the areas where he or she needs the most help. sometimes tutors or speech or language therapists also work with the children. learning disorders do not go away, but strategies to work around them can make them less of a problem. nih: national institute of neurological disorders and stroke

MalaCards: Learning Disability, also known as learning disorders, is related to attention deficit hyperactivity disorder and acrocephalosyndactylia. An important gene associated with Learning Disability is TTC8 (tetratricopeptide repeat domain 8), and among its related pathways are Adrenoceptors and Integrin alphaIIb beta3 signaling. The compounds [3h]mk-912 and [3h]rx821002 have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and breast, and related mouse phenotype embryogenesis.

Disease Ontology:8 A specific developmental disorder that involves difficulty in scholastic skills such as reading, writing, spelling, reasoning, recalling and/or organizing information resulting from the brain's inability to receive and process information.

NINDS:43 Learning disabilities are disorders that affect the ability to understand or use spoken or written language, do mathematical calculations, coordinate movements, or direct attention. Although learning disabilities occur in very young children, the disorders are usually not recognized until the child reaches school age. Research shows that 8 to 10 percent of American children under 18 years of age have some type of learning disability.

Wikipedia:63 Learning disability is a classification including several areas of functioning in which a person has... more...

Aliases & Classifications for Learning Disability

About this section
Sources:
8Disease Ontology, 22GTR, 10DISEASES, 63Wikipedia, 44Novoseek, 33MedlinePlus, 60UMLS, 43NINDS, 56SNOMED-CT, 34MeSH
See all sources

Aliases & Descriptions:

learning disability 8 22 10
learning disorders 63 44 33 60
learning disabilities 43 60
academic skill disorder 8
learning disorder 8


External Ids:

Disease Ontology8 DOID:8927
MeSH34 D007859

Related Diseases for Learning Disability

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Learning Disability via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1042)
idRelated DiseaseScoreTop Affiliating Genes
1attention deficit hyperactivity disorder30.6ADRA2C, ADRA2A, IMPACT
2acrocephalosyndactylia29.8TWISTNB, FERD3L
3schizophrenia10.4
4fragile x syndrome10.4
5developmental disabilities10.3
6dyslexia10.3
7neurofibromatosis10.3
8asperger syndrome10.3
9cervicitis10.3
10turner syndrome10.3
11epilepsy, x-linked, with variable learning disabilities and behavior disorders10.3
12dyscalculia10.2
13intellectual disability10.2
14sotos syndrome10.2
15neuronitis10.2
16autism spectrum disorder10.2
17obesity10.2
18weaver syndrome10.1
19tuberous sclerosis10.1
20dysgraphia10.1
21galactosemia10.1
22methylmalonic acidemia10.1
23personality disorder10.1
24schindler disease, type 110.1
25goldberg-shprintzen megacolon syndrome10.1
26shprintzen omphalocele syndrome10.1
27thanatophoric dysplasia type 110.1
28hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia10.1
29silver-russell syndrome10.0
30klippel-trenaunay syndrome10.0
31bloom syndrome10.0
32coffin-siris syndrome10.0
33incontinentia pigmenti achromians10.0
34autistic disorder10.0
35metachromatic leukodystrophy10.0
36landau-kleffner syndrome10.0
37phenylketonuria10.0
38renpenning syndrome10.0
39cleft palate10.0
40developmental coordination disorder10.0
41prader-willi syndrome10.0
42aphasia10.0
43bipolar disorder10.0
44cervical cancer10.0
45ischemia10.0
46mecp2 duplication syndrome10.0
47spastic paraplegia 110.0
48oculofaciocardiodental syndrome10.0
49feingold syndrome10.0
50cardiocranial syndrome10.0

Graphical network of the top 20 diseases related to Learning Disability:



Diseases related to learning disability

Clinical Features for Learning Disability

About this section

Drugs & Therapeutics for Learning Disability

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Learning Disability

Drug clinical trials:

Search ClinicalTrials for Learning Disability

Search NIH Clinical Center for Learning Disability

Search CenterWatch for Learning Disability

Genetic Tests for Learning Disability

About this section
Sources:
22GTR
See all sources

Genetic tests related to Learning Disability:

id Genetic test Affiliating Genes
1 Learning Disability22

Anatomical Context for Learning Disability

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Learning Disability:

32
Testes, Brain, Breast, Eye, Bone, Heart

Animal Models for Learning Disability or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Learning Disability:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053809.6GSC2, ADRA2C, ADRA2A, TBX1, PHOX2B, FERD3L

Publications for Learning Disability

About this section
Sources:
50PubMed
See all sources

Articles related to Learning Disability:

(show top 50)    (show all 539)
idTitleAuthorsYear
1
Association between phthalates and attention deficit disorder and learning disability in U.S. children, 6-15 years. (24267794)
2014
2
Limited knowledge of fraction representations differentiates middle school students with mathematics learning disability (dyscalculia) versus low mathematics achievement. (23587941)
2013
3
Health-related quality of life in children with specific learning disability: children's self-reports versus parents' proxy reports. (24292375)
2013
4
Memory processes in learning disability subtypes of children born preterm. (22375897)
2013
5
Nonverbal learning disability. (23622171)
2013
6
'Tolerating violence': a qualitative study into the experience of professionals working within one UK learning disability service. (23647490)
2013
7
Pressure to prescribe antipsychotic drugs in learning disability too. (22474277)
2012
8
Between negative stigma (cultural deprivation) and positive stigma (learning disability): the historical development of two special education tracks. (23065104)
2012
9
Drawing on three discursive modes in learning disability nurse education. (18829142)
2009
10
People with a learning disability and dysphagia: a cinderella population? (18516639)
2009
11
Effects of treatment with oxandrolone for 4 years on the frequency of severe arithmetic learning disability in girls with Turner syndrome. (19643440)
2009
12
First-Grade Predictors of Mathematical Learning Disability: A Latent Class Trajectory Analysis. (20046817)
2009
13
'It's the system working for the system': carers' experiences of learning disability services in Ireland. (18800982)
2009
14
Galvanising the role of learning disability nursing. (18481396)
2008
15
Community learning disability teams: developments, composition and good practice: a review of the literature. (18337302)
2008
16
Contriving establishing operations: responses of individuals with developmental disabilities during a learning task. (17420114)
2008
17
Interactions between seizure frequency, psychopathology, and severity of intellectual disability in a population with epilepsy and a learning disability. (17521964)
2007
18
Association of serum concentrations of persistent organic pollutants with the prevalence of learning disability and attention deficit disorder. (17568050)
2007
19
Community learning disability teams: perceived effectiveness, multidisciplinary working and service user satisfaction. (18029410)
2007
20
Array-based comparative genomic hybridization for investigating chromosomal abnormalities in patients with learning disability: systematic review meta-analysis of diagnostic and false-positive yields. (17304048)
2007
21
Does learning disability nursing have a future? (18271286)
2007
22
Russell-Silver syndrome and nonverbal learning disability: a case study. (17523887)
2007
23
Idiopathic learning disability and genome imbalance. (17124403)
2006
24
Risperidone induced oedema in a child with learning disability and autism. (16682401)
2006
25
Test of the definition of learning disability based on the difference between IQ and achievement. (16279312)
2005
26
Processing abilities associated with phonologic and orthographic skills in adult learning disability. (16019631)
2005
27
The reliability of balance, mobility and self-care measures in a population of adults with a learning disability known to a physiotherapy service. (15759538)
2005
28
Kindergarten Predictors of Math Learning Disability. (20084182)
2005
29
A multi-functional, portable device with wireless transmission for home monitoring of children with a learning disability. (15494089)
2004
30
Patient with partial trisomy 9q and learning disability but no pyloric stenosis. (14974649)
2004
31
Assessing the needs of people with learning disabilities and mental illness: development of the Learning Disability version of the Cardinal Needs Schedule. (14675228)
2004
32
Interprofessional practice and learning disability nursing. (14688655)
2003
33
Behaviour modification and gentle teaching workshops: management of children with learning disabilities exhibiting challenging behaviour and implications for learning disability nursing. (11430611)
2001
34
An evaluation of community learning disability services for children with a learning disability. (12664722)
2001
35
Chromosome 22q11 deletions and severe learning disability. (11689418)
2001
36
Issues emerging from the London Learning Disability Plan. (12170662)
2001
37
'Valuing people'--a new strategy for learning disability for the 21st century: how may it impinge on primary care? (11677700)
2001
38
Multidisciplinary and multiagency contributions to care for those with learning disability who have epilepsy. (11422361)
2001
39
Diagnostic review of 66 children with learning disability attending a single centre. (11495239)
2001
40
Nurse networks in learning disability. (11968667)
2000
41
Mapping studies on a pericentric inversion (18) (p11.31 q21.1) in a family with both schizophrenia and learning disability. (10551549)
1999
42
Learning disability: promoting health equality in the community. (10532000)
1999
43
Patients with learning disability in the community. (10024249)
1999
44
Normal adaptive function with learning disability in duplication 8p including band p22. (9674899)
1998
45
Breast awareness project for women with a learning disability. (9732569)
1998
46
Learning disability subtypes in children with neurofibromatosis. (9293234)
1997
47
The effect of traumatic brain injury on children with learning disability. (9689253)
1997
48
Validity of the PAS-ADD for detecting psychiatric symptoms in adults with learning disability (mental retardation). (9299929)
1997
49
Reliability of theory of mind task performance by individuals with a learning disability: a research note. (9315982)
1997
50
Histrionic personality disorder as pseudo-learning disability. (8555723)
1995

Genetic Variations for Learning Disability

About this section

Expression for genes affiliated with Learning Disability

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Learning Disability

Search GEO for disease gene expression data for Learning Disability.

Pathways for genes affiliated with Learning Disability

About this section
Sources:
53Reactome, 49PharmGKB
See all sources

Pathways related to Learning Disability according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3ADRA2C, ADRA2A
2
Hide members
10.3ADRA2C, ADRA2A

Compounds for genes affiliated with Learning Disability

About this section
Sources:
28IUPHAR, 59Tocris Bioscience, 11DrugBank, 44Novoseek, 49PharmGKB, 24HMDB
See all sources

Compounds related to Learning Disability according to GeneCards/GeneDecks:

(show all 45)
idCompoundScoreTop Affiliating Genes
1[3h]mk-9122810.7ADRA2A, ADRA2C
2[3h]rx8210022810.7ADRA2C, ADRA2A
3rx8210022810.7ADRA2C, ADRA2A
4arc-2392810.7ADRA2C, ADRA2A
5brl 444082810.7ADRA2C, ADRA2A
6brl 44408 maleate5910.7ADRA2A, ADRA2C
7dexmedetomidine hydrochloride5910.7ADRA2C, ADRA2A
8atipamezole hydrochloride5910.7ADRA2C, ADRA2A
9jp 1302 dihydrochloride5910.7ADRA2C, ADRA2A
10medetomidine hydrochloride5910.7ADRA2C, ADRA2A
11Bethanidine1110.7ADRA2A, ADRA2C
12xylazine28 4411.7ADRA2A, ADRA2C
13[3h]rauwolscine2810.7ADRA2A, ADRA2C
14tizanidine44 1111.7ADRA2C, ADRA2A
15Xylometazoline1110.6ADRA2A, ADRA2C
16guanfacine28 44 1112.6ADRA2A, ADRA2C
17wb 41012810.6ADRA2A, ADRA2C
18Lurasidone1110.6ADRA2A, ADRA2C
19(-)-noradrenaline2810.6ADRA2A, ADRA2C
20rauwolscine2810.6ADRA2A, ADRA2C
21piribedil28 4411.6ADRA2A, ADRA2C
22spiroxatrine28 4411.6ADRA2A, ADRA2C
23dexmedetomidine28 44 1112.6ADRA2A, ADRA2C
24fenoldopam44 1111.6ADRA2A, ADRA2C
25oxymetazoline28 44 1112.6ADRA2A, ADRA2C
26brimonidine28 44 1112.6ADRA2C, ADRA2A
27Droxidopa1110.6ADRA2A, ADRA2C
28phenoxybenzamine44 1111.5ADRA2A, ADRA2C
29Ephedra1110.5ADRA2C, ADRA2A
30terguride28 4411.5ADRA2C, ADRA2A
31methamphetamine44 49 1112.5CNTF, ADRA2A, ADRA2C
32phentolamine28 44 1112.5ADRA2C, ADRA2A
33ropinirole44 1111.5ADRA2C, ADRA2A
34lisuride28 44 1112.5ADRA2A, ADRA2C
35Dronedarone1110.4ADRA2A, ADRA2C
36paliperidone44 1111.4ADRA2A, ADRA2C
37catecholamine4410.4CNTF, ADRA2A, ADRA2C
38pergolide28 44 1112.4ADRA2A, ADRA2C
39Methotrimeprazine1110.3ADRA2A, ADRA2C
40norepinephrine44 11 2412.3ADRA2C, ADRA2A, PF4, CNTF, PHOX2B
41pramipexole44 49 28 1113.3ADRA2A, ADRA2C
42doxepin44 28 49 1113.3ADRA2C, ADRA2A
43dopamine44 28 11 2413.2PHOX2B, CNTF, PF4, ADRA2A, ADRA2C
44asenapine28 1111.2ADRA2C, ADRA2A
45cabergoline28 44 1112.0ADRA2C, ADRA2A

GO Terms for genes affiliated with Learning Disability

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Learning Disability according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1BBSomeGO:03446410.3TTC8, BBS5

Biological processes related to Learning Disability according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of uterine smooth muscle contractionGO:07047310.4ADRA2C, ADRA2A
2activation of MAPK activity by adrenergic receptor signaling pathwayGO:07188310.4ADRA2C, ADRA2A
3epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathwayGO:03562510.3ADRA2C, ADRA2A
4negative regulation of epinephrine secretionGO:03281110.3ADRA2A, ADRA2C
5activation of protein kinase B activityGO:03214810.3ADRA2C, ADRA2A
6muscle organ morphogenesisGO:04864410.1CNTF, TBX1
7negative regulation of norepinephrine secretionGO:01070010.0ADRA2C, ADRA2A

Molecular functions related to Learning Disability according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1epinephrine bindingGO:05137910.3ADRA2C, ADRA2A
2alpha2-adrenergic receptor activityGO:00493810.0ADRA2C, ADRA2A

Products for genes affiliated with Learning Disability

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Learning Disability

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet