MCID: LRN003
MIFTS: 58

Learning Disability malady

Summaries for Learning Disability

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Sources:
8Disease Ontology, 33MedlinePlus, 43NINDS, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Learning disorders affect how a person understands, remembers and responds to new information. people with learning disorders may have problems listening or paying attention speaking reading or writing doing math although learning disorders occur in very young children, they are usually not recognized until the child reaches school age. about one-third of children who have learning disabilities also have adhd, which makes it hard to focus. evaluation and testing by a trained professional can help identify a learning disorder. the next step is special education, which involves helping your child in the areas where he or she needs the most help. sometimes tutors or speech or language therapists also work with the children. learning disorders do not go away, but strategies to work around them can make them less of a problem. nih: national institute of neurological disorders and stroke

MalaCards: Learning Disability, also known as learning disorders, is related to attention deficit hyperactivity disorder and acrocephalosyndactylia. An important gene associated with Learning Disability is TTC8 (tetratricopeptide repeat domain 8), and among its related pathways are Adrenoceptors and Integrin alphaIIb beta3 signaling. The compounds [3h]mk-912 and [3h]rx821002 have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and breast, and related mouse phenotype embryogenesis.

Disease Ontology:8 A specific developmental disorder that involves difficulty in scholastic skills such as reading, writing, spelling, reasoning, recalling and/or organizing information resulting from the brain's inability to receive and process information.

NINDS:43 Learning disabilities are disorders that affect the ability to understand or use spoken or written language, do mathematical calculations, coordinate movements, or direct attention. Although learning disabilities occur in very young children, the disorders are usually not recognized until the child reaches school age. Research shows that 8 to 10 percent of American children under 18 years of age have some type of learning disability.

Wikipedia:63 Learning disability is a classification including several areas of functioning in which a person has... more...

Aliases & Classifications for Learning Disability

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Sources:
8Disease Ontology, 22GTR, 10DISEASES, 63Wikipedia, 44Novoseek, 33MedlinePlus, 60UMLS, 43NINDS, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

learning disability 8 22 10
learning disorders 63 44 33 60
learning disabilities 43 60
academic skill disorder 8
learning disorder 8


External Ids:

Disease Ontology8 DOID:8927
MeSH34 D007859

Related Diseases for Learning Disability

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Learning Disability via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1042)
idRelated DiseaseScoreTop Affiliating Genes
1attention deficit hyperactivity disorder30.6ADRA2C, ADRA2A, IMPACT
2acrocephalosyndactylia29.8TWISTNB, FERD3L
3schizophrenia10.4
4fragile x syndrome10.4
5developmental disabilities10.3
6dyslexia10.3
7neurofibromatosis10.3
8asperger syndrome10.3
9cervicitis10.3
10turner syndrome10.3
11epilepsy, x-linked, with variable learning disabilities and behavior disorders10.3
12dyscalculia10.2
13intellectual disability10.2
14sotos syndrome10.2
15neuronitis10.2
16autism spectrum disorder10.2
17obesity10.2
18weaver syndrome10.1
19tuberous sclerosis10.1
20dysgraphia10.1
21galactosemia10.1
22methylmalonic acidemia10.1
23personality disorder10.1
24schindler disease, type 110.1
25goldberg-shprintzen megacolon syndrome10.1
26shprintzen omphalocele syndrome10.1
27thanatophoric dysplasia type 110.1
28hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia10.1
29silver-russell syndrome10.0
30klippel-trenaunay syndrome10.0
31bloom syndrome10.0
32coffin-siris syndrome10.0
33incontinentia pigmenti achromians10.0
34autistic disorder10.0
35metachromatic leukodystrophy10.0
36landau-kleffner syndrome10.0
37phenylketonuria10.0
38renpenning syndrome10.0
39cleft palate10.0
40developmental coordination disorder10.0
41prader-willi syndrome10.0
42aphasia10.0
43bipolar disorder10.0
44cervical cancer10.0
45ischemia10.0
46mecp2 duplication syndrome10.0
47spastic paraplegia 110.0
48oculofaciocardiodental syndrome10.0
49feingold syndrome10.0
50cardiocranial syndrome10.0

Graphical network of the top 20 diseases related to Learning Disability:



Diseases related to learning disability

Clinical Features for Learning Disability

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Drugs & Therapeutics for Learning Disability

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Learning Disability

Drug clinical trials:

Search ClinicalTrials for Learning Disability

Search NIH Clinical Center for Learning Disability

Search CenterWatch for Learning Disability

Genetic Tests for Learning Disability

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Sources:
22GTR
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Genetic tests related to Learning Disability:

id Genetic test Affiliating Genes
1 Learning Disability22

Anatomical Context for Learning Disability

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Sources:
32MalaCards
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MalaCards organs/tissues related to Learning Disability:

32
Testes, Brain, Breast, Bone, Eye, Heart

Animal Models for Learning Disability or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Learning Disability:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053809.6GSC2, ADRA2C, ADRA2A, TBX1, PHOX2B, FERD3L

Publications for Learning Disability

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Sources:
50PubMed
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Articles related to Learning Disability:

(show top 50)    (show all 539)
idTitleAuthorsYear
1
Managing eating and drinking difficulties (dysphagia) with children who have learning disabilities: What is effective? (24414040)
2014
2
Exemplar variability facilitates rapid learning of an otherwise unlearnable grammar by individuals with language-based learning disability. (22988285)
2013
3
GATAD2B loss-of-function mutations cause a recognisable syndrome with intellectual disability and are associated with learning deficits and synaptic undergrowth in Drosophila. (23644463)
2013
4
An analysis of the criteria used to diagnose children with Nonverbal Learning Disability (NLD). (23705673)
2013
5
Self-perceived health-related quality of life of Indian children with specific learning disability. (23298918)
2012
6
The impact of social policy on changes in professional practice within learning disability services: different standards for children and adults? A two-part examination: part 2. Professional services under the coalition: the trends continue apace. (22190570)
2011
7
A problem with inclusion in learning disability research. (21642332)
2011
8
A new autosomal dominant syndrome of distinctive face showing ptosis and prominent eyes associated with cleft palate, ear anomalies, and learning disability. (21834043)
2011
9
Reconstructing professional identity for professional and interprofessional practice: a mixed methods study of joint training programmes in learning disability nursing and social work. (21554063)
2011
10
'It terrifies me, the thought of the future': listening to the current concerns of informal carers of people with a learning disability. (20630924)
2010
11
Getting it right for people with a learning disability. (20606608)
2010
12
Semi-dominant X-chromosome linked learning disability with progressive ataxia, spasticity and dystonia associated with the novel MECP2 variant p.V122A: akin to the new MECP2 duplication syndrome? (19592282)
2010
13
A review of mathematical learning disabilities in children with fragile X syndrome. (19213014)
2009
14
A survey of learning disability inpatient services in Scotland in 2007. (19628535)
2009
15
Learning disability. (19275837)
2009
16
College students with learning disability diagnoses: who are they and how do they perform? (19704046)
2009
17
Learning disability nurse education: an opportunity to contribute to shaping the future? (19786500)
2009
18
Dental Discomfort Questionnaire: its use with children with a learning disability. (18647374)
2008
19
Stability of computational deficits in math learning disability from second through fifth grades. (18473201)
2008
20
Is learning disability nursing undervalued? (18524342)
2008
21
Impact of an education program on parental knowledge of specific learning disability. (17611345)
2007
22
Rash from antiepileptic drugs: influence by gender, age, and learning disability. (17484761)
2007
23
The views and experiences of learning disability nurses concerning their advocacy education. (17574711)
2007
24
Clinical and psychoeducational profile of children with specific learning disability and co-occurring attention-deficit hyperactivity disorder. (18174633)
2007
25
Family nursing and parents who have a learning disability. (16544798)
2006
26
The diagnosis and management of learning disability. (17066889)
2006
27
Disruption of a brain transcription factor, NPAS3, is associated with schizophrenia and learning disability. (15924306)
2005
28
Women with learning disability and uptake of screening: audit of screening uptake before and after one to one counselling. (16199408)
2005
29
Role of cognitive theory in the study of learning disability in mathematics. (16122060)
2005
30
Antipsychotic medication for challenging behaviour in people with learning disability. (15266428)
2004
31
When Asperger's syndrome and a nonverbal learning disability look alike. (15194904)
2004
32
Dietary omega-3 fatty acids normalize BDNF levels, reduce oxidative damage, and counteract learning disability after traumatic brain injury in rats. (15672635)
2004
33
One size still does not fit all in specific learning disability assessment across ethnic groups. (15493248)
2002
34
Health promotion and learning disability. (11949569)
2002
35
Dysmorphic features and learning disability in an adult male with pure partial trisomy 17q24-q25 due to a terminal duplication. (12244560)
2002
36
Antipsychotic medication for those with both schizophrenia and learning disability. (11405947)
2001
37
Who should care for people with learning disabilities. Community learning disability nurses must get recognition they deserve. (11303531)
2001
38
Long-term affective disorder in people with mild learning disability. (11731356)
2001
39
The epidemiology of epilepsy and learning disability. (11422344)
2001
40
Therapeutic caring: a learning disability experience. (11855800)
2001
41
Additive effect of three noradrenergic genes (ADRA2a, ADRA2C, DBH) on attention-deficit hyperactivity disorder and learning disabilities in Tourette syndrome subjects. (10334470)
1999
42
Only one quarter of women with learning disability in Exeter have cervical screening. (9641948)
1998
43
FRAXA and FRAXE: evidence against segregation distortion and for an effect of intermediate alleles on learning disability. (9435259)
1998
44
Structural neuroimaging in learning disability. (9519079)
1998
45
Coping with a learning disability in medical school. (9424052)
1998
46
Using models in learning disability nursing. (9248449)
1997
47
Learning disabilities and language pathology in patients with galactosemia. (21275587)
1996
48
Validity and neuropsychological characterization of Asperger syndrome: convergence with nonverbal learning disabilities syndrome. (8847376)
1995
49
Protective effect of basic fibroblast growth factor-heparin and neurotoxic effect of platelet factor 4 on ischemic neuronal loss and learning disability in gerbils. (7777164)
1995
50
Conversion disorder with pseudoseizures in adolescence: a stress reaction to unrecognized and untreated learning disabilities. (7130563)
1982

Genetic Variations for Learning Disability

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Expression for genes affiliated with Learning Disability

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Learning Disability

Search GEO for disease gene expression data for Learning Disability.

Pathways for genes affiliated with Learning Disability

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Sources:
53Reactome, 49PharmGKB
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Pathways related to Learning Disability according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3ADRA2C, ADRA2A
2
Hide members
10.3ADRA2C, ADRA2A

Compounds for genes affiliated with Learning Disability

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Sources:
28IUPHAR, 59Tocris Bioscience, 11DrugBank, 44Novoseek, 49PharmGKB, 24HMDB
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Compounds related to Learning Disability according to GeneCards/GeneDecks:

(show all 45)
idCompoundScoreTop Affiliating Genes
1[3h]mk-9122810.7ADRA2A, ADRA2C
2[3h]rx8210022810.7ADRA2C, ADRA2A
3rx8210022810.7ADRA2C, ADRA2A
4arc-2392810.7ADRA2C, ADRA2A
5brl 444082810.7ADRA2C, ADRA2A
6brl 44408 maleate5910.7ADRA2A, ADRA2C
7dexmedetomidine hydrochloride5910.7ADRA2C, ADRA2A
8atipamezole hydrochloride5910.7ADRA2C, ADRA2A
9jp 1302 dihydrochloride5910.7ADRA2C, ADRA2A
10medetomidine hydrochloride5910.7ADRA2C, ADRA2A
11Bethanidine1110.7ADRA2A, ADRA2C
12xylazine28 4411.7ADRA2A, ADRA2C
13[3h]rauwolscine2810.7ADRA2A, ADRA2C
14tizanidine44 1111.7ADRA2C, ADRA2A
15Xylometazoline1110.6ADRA2A, ADRA2C
16guanfacine28 44 1112.6ADRA2A, ADRA2C
17wb 41012810.6ADRA2A, ADRA2C
18Lurasidone1110.6ADRA2A, ADRA2C
19(-)-noradrenaline2810.6ADRA2A, ADRA2C
20rauwolscine2810.6ADRA2A, ADRA2C
21piribedil28 4411.6ADRA2A, ADRA2C
22spiroxatrine28 4411.6ADRA2A, ADRA2C
23dexmedetomidine28 44 1112.6ADRA2A, ADRA2C
24fenoldopam44 1111.6ADRA2A, ADRA2C
25oxymetazoline28 44 1112.6ADRA2A, ADRA2C
26brimonidine28 44 1112.6ADRA2C, ADRA2A
27Droxidopa1110.6ADRA2A, ADRA2C
28phenoxybenzamine44 1111.5ADRA2A, ADRA2C
29Ephedra1110.5ADRA2C, ADRA2A
30terguride28 4411.5ADRA2C, ADRA2A
31methamphetamine44 49 1112.5CNTF, ADRA2A, ADRA2C
32phentolamine28 44 1112.5ADRA2C, ADRA2A
33ropinirole44 1111.5ADRA2C, ADRA2A
34lisuride28 44 1112.5ADRA2A, ADRA2C
35Dronedarone1110.4ADRA2A, ADRA2C
36paliperidone44 1111.4ADRA2A, ADRA2C
37catecholamine4410.4CNTF, ADRA2A, ADRA2C
38pergolide28 44 1112.4ADRA2A, ADRA2C
39Methotrimeprazine1110.3ADRA2A, ADRA2C
40norepinephrine44 11 2412.3ADRA2C, ADRA2A, PF4, CNTF, PHOX2B
41pramipexole44 49 28 1113.3ADRA2A, ADRA2C
42doxepin44 28 49 1113.3ADRA2C, ADRA2A
43dopamine44 28 11 2413.2PHOX2B, CNTF, PF4, ADRA2A, ADRA2C
44asenapine28 1111.2ADRA2C, ADRA2A
45cabergoline28 44 1112.0ADRA2C, ADRA2A

GO Terms for genes affiliated with Learning Disability

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Sources:
16Gene Ontology
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Cellular components related to Learning Disability according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1BBSomeGO:03446410.3TTC8, BBS5

Biological processes related to Learning Disability according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of uterine smooth muscle contractionGO:07047310.4ADRA2A, ADRA2C
2activation of MAPK activity by adrenergic receptor signaling pathwayGO:07188310.4ADRA2A, ADRA2C
3epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathwayGO:03562510.3ADRA2A, ADRA2C
4negative regulation of epinephrine secretionGO:03281110.3ADRA2A, ADRA2C
5activation of protein kinase B activityGO:03214810.3ADRA2A, ADRA2C
6muscle organ morphogenesisGO:04864410.1CNTF, TBX1
7negative regulation of norepinephrine secretionGO:01070010.0ADRA2A, ADRA2C

Molecular functions related to Learning Disability according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1epinephrine bindingGO:05137910.3ADRA2C, ADRA2A
2alpha2-adrenergic receptor activityGO:00493810.0ADRA2C, ADRA2A

Products for genes affiliated with Learning Disability

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Learning Disability

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet