MCID: LRN003
MIFTS: 58

Learning Disability malady

Summaries for Learning Disability

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Sources:
8Disease Ontology, 33MedlinePlus, 43NINDS, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Learning disorders affect how a person understands, remembers and responds to new information. people with learning disorders may have problems listening or paying attention speaking reading or writing doing math although learning disorders occur in very young children, they are usually not recognized until the child reaches school age. about one-third of children who have learning disabilities also have adhd, which makes it hard to focus. evaluation and testing by a trained professional can help identify a learning disorder. the next step is special education, which involves helping your child in the areas where he or she needs the most help. sometimes tutors or speech or language therapists also work with the children. learning disorders do not go away, but strategies to work around them can make them less of a problem. nih: national institute of neurological disorders and stroke

MalaCards: Learning Disability, also known as learning disorders, is related to attention deficit hyperactivity disorder and acrocephalosyndactylia. An important gene associated with Learning Disability is TTC8 (tetratricopeptide repeat domain 8), and among its related pathways are Adrenoceptors and Integrin alphaIIb beta3 signaling. The compounds [3h]mk-912 and [3h]rx821002 have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and breast, and related mouse phenotype embryogenesis.

Disease Ontology:8 A specific developmental disorder that involves difficulty in scholastic skills such as reading, writing, spelling, reasoning, recalling and/or organizing information resulting from the brain's inability to receive and process information.

NINDS:43 Learning disabilities are disorders that affect the ability to understand or use spoken or written language, do mathematical calculations, coordinate movements, or direct attention. Although learning disabilities occur in very young children, the disorders are usually not recognized until the child reaches school age. Research shows that 8 to 10 percent of American children under 18 years of age have some type of learning disability.

Wikipedia:63 Learning disability is a classification including several areas of functioning in which a person has... more...

Aliases & Classifications for Learning Disability

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Sources:
8Disease Ontology, 22GTR, 10DISEASES, 63Wikipedia, 44Novoseek, 33MedlinePlus, 60UMLS, 43NINDS, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

learning disability 8 22 10
learning disorders 63 44 33 60
learning disabilities 43 60
academic skill disorder 8
learning disorder 8


External Ids:

Disease Ontology8 DOID:8927
MeSH34 D007859

Related Diseases for Learning Disability

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Learning Disability via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1042)
idRelated DiseaseScoreTop Affiliating Genes
1attention deficit hyperactivity disorder30.6ADRA2C, ADRA2A, IMPACT
2acrocephalosyndactylia29.8TWISTNB, FERD3L
3schizophrenia10.4
4fragile x syndrome10.4
5developmental disabilities10.3
6dyslexia10.3
7neurofibromatosis10.3
8asperger syndrome10.3
9cervicitis10.3
10turner syndrome10.3
11epilepsy, x-linked, with variable learning disabilities and behavior disorders10.3
12dyscalculia10.2
13intellectual disability10.2
14sotos syndrome10.2
15neuronitis10.2
16autism spectrum disorder10.2
17obesity10.2
18weaver syndrome10.1
19tuberous sclerosis10.1
20dysgraphia10.1
21galactosemia10.1
22methylmalonic acidemia10.1
23personality disorder10.1
24schindler disease, type 110.1
25goldberg-shprintzen megacolon syndrome10.1
26shprintzen omphalocele syndrome10.1
27thanatophoric dysplasia type 110.1
28hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia10.1
29silver-russell syndrome10.0
30klippel-trenaunay syndrome10.0
31bloom syndrome10.0
32coffin-siris syndrome10.0
33incontinentia pigmenti achromians10.0
34autistic disorder10.0
35metachromatic leukodystrophy10.0
36landau-kleffner syndrome10.0
37phenylketonuria10.0
38renpenning syndrome10.0
39cleft palate10.0
40developmental coordination disorder10.0
41prader-willi syndrome10.0
42aphasia10.0
43bipolar disorder10.0
44cervical cancer10.0
45ischemia10.0
46mecp2 duplication syndrome10.0
47spastic paraplegia 110.0
48oculofaciocardiodental syndrome10.0
49feingold syndrome10.0
50cardiocranial syndrome10.0

Graphical network of the top 20 diseases related to Learning Disability:



Diseases related to learning disability

Clinical Features for Learning Disability

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Drugs & Therapeutics for Learning Disability

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Learning Disability

Drug clinical trials:

Search ClinicalTrials for Learning Disability

Search NIH Clinical Center for Learning Disability

Search CenterWatch for Learning Disability

Genetic Tests for Learning Disability

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Sources:
22GTR
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Genetic tests related to Learning Disability:

id Genetic test Affiliating Genes
1 Learning Disability22

Anatomical Context for Learning Disability

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Sources:
32MalaCards
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MalaCards organs/tissues related to Learning Disability:

32
Testes, Brain, Breast, Eye, Bone, Heart

Animal Models for Learning Disability or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Learning Disability:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053809.6GSC2, ADRA2C, ADRA2A, TBX1, PHOX2B, FERD3L

Publications for Learning Disability

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Sources:
50PubMed
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Articles related to Learning Disability:

(show top 50)    (show all 539)
idTitleAuthorsYear
1
Handedness and language learning disability differentially distribute in progressive aphasia variants. (24056533)
2013
2
What knowledge and attitudes do paid carers of people with a learning disability have about cancer? (23279077)
2013
3
The identification and performance of gifted students with learning disability diagnoses: a quantitative synthesis. (22057201)
2013
4
Do individuals with intellectual disability select appropriate objects as landmarks when learning a new route? (23228196)
2013
5
Association between urine cotinine levels, continuous performance test variables, and attention deficit hyperactivity disorder and learning disability symptoms in school-aged children. (22608159)
2013
6
End of life care for people with a learning disability. (23082363)
2012
7
Adaptive behaviour in children and adolescents with foetal alcohol spectrum disorders: a comparison with specific learning disability and typical development. (22358422)
2012
8
A novel mutation in the HSD17B10 gene of a 10-year-old boy with refractory epilepsy, choreoathetosis and learning disability. (22132097)
2011
9
Learning disability and oligodendrocyte myelin glycoprotein (OMGP) gene in neurofibromatosis type 1. (21534343)
2011
10
Impact of parenting practices on parent-child relationships in children with specific learning disability. (21220910)
2011
11
Learning from Samuel A. Kirk's 16 versions of learning disability: a rejoinder to Mather and Morris. (21446875)
2011
12
Another joint statement regarding learning disabilities, dyslexia, and vision--a rebuttal. (20728412)
2010
13
Improving the management of children with learning disability and autism spectrum disorder when they attend hospital. (21039752)
2010
14
The Regression-Based Discrepancy Definition of Learning Disability: A Critical Appraisal. (20375287)
2010
15
A nonverbal learning disability in a case of central hypoventilation syndrome without a PHOX2B gene mutation. (19813116)
2010
16
Impairment of simultaneous-spatial working memory in nonverbal (visuospatial) learning disability: a treatment case study. (19370448)
2009
17
The role of the teacher in identifying learning disabilities: a study using the McCarney Learning Disability Evaluation Scale (LDES). (19458208)
2009
18
Implementing epilepsy guidelines within a learning disability service. (17467302)
2007
19
Long-term retention rates of new antiepileptic drugs in adults with chronic epilepsy and learning disability. (17267290)
2007
20
Cognitive characteristics of children with mathematics learning disability (MLD) vary as a function of the cutoff criterion used to define MLD. (17915500)
2007
21
The word reading test of effort in adult learning disability: a simulation study. (16690550)
2006
22
Prader-Willi-like phenotype: investigation of 1p36 deletion in 41 patients with delayed psychomotor development, hypotonia, obesity and/or hyperphagia, learning disabilities and behavioral problems. (16564757)
2006
23
Improving primary care services for people with learning disability. (15658237)
2005
24
Cognition in specific learning disability. (16388151)
2005
25
Confounding factors for depression in adults with mild learning disability. (15994578)
2005
26
Learning disability: occurrence and long-term consequences in childhood-onset epilepsy. (15582842)
2004
27
Ectopic neurons in the hippocampus may be a cause of learning disability after prenatal exposure to X-rays in rats. (15635267)
2004
28
Brief cognitive therapy of nightmares and post-traumatic ruminations in a man with a learning disability. (15530215)
2004
29
The education and training needs of learning disability staff in relation to mental health issues. (19038134)
2004
30
Quality of life as a concept for developing learning disability nursing practice? (12519251)
2003
31
Autism spectrum disorders in children with active epilepsy and learning disability: comorbidity, pre- and perinatal background, and seizure characteristics. (14580127)
2003
32
Attention deficit hyperactivity disorder: review of ADHD in learning disability: the Diagnostic Criteria for Psychiatric Disorders for Use with Adults with Learning Disabilities/Mental Retardation[DC-LD] criteria for diagnosis. (14516370)
2003
33
Development and psychometric properties of the Glasgow Depression Scale for people with a Learning Disability. Individual and carer supplement versions. (12668412)
2003
34
A rapid screening measure for the identification of visuospatial learning disability in schools. (15490903)
2003
35
A study to determine the qualities of a learning disability practitioner. (12514472)
2002
36
Sexual abuse and learning disability. (16259824)
2002
37
How does the severity of a learning disability affect working memory performance? (11747580)
2001
38
Responding to people with a learning disability who offend. (12205764)
2001
39
Antipsychotic medication for those with both schizophrenia and learning disability. (11686948)
2001
40
Suicide prevention training for Aboriginal young adults with learning disabilities from Fetal Alcohol Syndrome/Fetal Alcohol Effects (FAS/FAE). (11768436)
2001
41
Reducing antipsychotic medication in people with a learning disability. (10789325)
2000
42
Health screening for people with learning disabilities by a community learning disability nursing service in Northern Ireland. (10354244)
1999
43
One from the heart for people with a learning disability. (10214139)
1999
44
Communication skills workshops in learning disability nursing. (10214138)
1999
45
Korean red ginseng saponins with low ratios of protopanaxadiol and protopanaxatriol saponin improve scopolamine-induced learning disability and spatial working memory in mice. (10433468)
1999
46
'A woman's heaven is at her husband's feet'? The dilemmas for a community learning disability team posed by the arranged marriage of a Bangladeshi client with intellectual disability. (10622372)
1999
47
Dental services for adults with a learning disability: care managers' experiences and opinions. (9973731)
1998
48
Brief report: motor incoordination in children with Asperger syndrome and learning disabilities. (9403374)
1997
49
Nonverbal learning disabilities, Asperger's syndrome, pervasive developmental disorder--should we care? (9120217)
1996
50
The neuropsychological profile of cri du chat syndrome without significant learning disability. (8870615)
1996

Genetic Variations for Learning Disability

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Expression for genes affiliated with Learning Disability

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Learning Disability

Search GEO for disease gene expression data for Learning Disability.

Pathways for genes affiliated with Learning Disability

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Sources:
53Reactome, 49PharmGKB
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Pathways related to Learning Disability according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3ADRA2C, ADRA2A
2
Hide members
10.3ADRA2C, ADRA2A

Compounds for genes affiliated with Learning Disability

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Sources:
28IUPHAR, 59Tocris Bioscience, 11DrugBank, 44Novoseek, 49PharmGKB, 24HMDB
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Compounds related to Learning Disability according to GeneCards/GeneDecks:

(show all 45)
idCompoundScoreTop Affiliating Genes
1[3h]mk-9122810.7ADRA2A, ADRA2C
2[3h]rx8210022810.7ADRA2C, ADRA2A
3rx8210022810.7ADRA2C, ADRA2A
4arc-2392810.7ADRA2C, ADRA2A
5brl 444082810.7ADRA2C, ADRA2A
6brl 44408 maleate5910.7ADRA2A, ADRA2C
7dexmedetomidine hydrochloride5910.7ADRA2C, ADRA2A
8atipamezole hydrochloride5910.7ADRA2C, ADRA2A
9jp 1302 dihydrochloride5910.7ADRA2C, ADRA2A
10medetomidine hydrochloride5910.7ADRA2C, ADRA2A
11Bethanidine1110.7ADRA2A, ADRA2C
12xylazine28 4411.7ADRA2A, ADRA2C
13[3h]rauwolscine2810.7ADRA2A, ADRA2C
14tizanidine44 1111.7ADRA2C, ADRA2A
15Xylometazoline1110.6ADRA2A, ADRA2C
16guanfacine28 44 1112.6ADRA2A, ADRA2C
17wb 41012810.6ADRA2A, ADRA2C
18Lurasidone1110.6ADRA2A, ADRA2C
19(-)-noradrenaline2810.6ADRA2A, ADRA2C
20rauwolscine2810.6ADRA2A, ADRA2C
21piribedil28 4411.6ADRA2A, ADRA2C
22spiroxatrine28 4411.6ADRA2A, ADRA2C
23dexmedetomidine28 44 1112.6ADRA2A, ADRA2C
24fenoldopam44 1111.6ADRA2A, ADRA2C
25oxymetazoline28 44 1112.6ADRA2A, ADRA2C
26brimonidine28 44 1112.6ADRA2C, ADRA2A
27Droxidopa1110.6ADRA2A, ADRA2C
28phenoxybenzamine44 1111.5ADRA2A, ADRA2C
29Ephedra1110.5ADRA2C, ADRA2A
30terguride28 4411.5ADRA2C, ADRA2A
31methamphetamine44 49 1112.5CNTF, ADRA2A, ADRA2C
32phentolamine28 44 1112.5ADRA2C, ADRA2A
33ropinirole44 1111.5ADRA2C, ADRA2A
34lisuride28 44 1112.5ADRA2A, ADRA2C
35Dronedarone1110.4ADRA2A, ADRA2C
36paliperidone44 1111.4ADRA2A, ADRA2C
37catecholamine4410.4CNTF, ADRA2A, ADRA2C
38pergolide28 44 1112.4ADRA2A, ADRA2C
39Methotrimeprazine1110.3ADRA2A, ADRA2C
40norepinephrine44 11 2412.3ADRA2C, ADRA2A, PF4, CNTF, PHOX2B
41pramipexole44 49 28 1113.3ADRA2A, ADRA2C
42doxepin44 28 49 1113.3ADRA2C, ADRA2A
43dopamine44 28 11 2413.2PHOX2B, CNTF, PF4, ADRA2A, ADRA2C
44asenapine28 1111.2ADRA2C, ADRA2A
45cabergoline28 44 1112.0ADRA2C, ADRA2A

GO Terms for genes affiliated with Learning Disability

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16Gene Ontology
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Cellular components related to Learning Disability according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1BBSomeGO:03446410.3TTC8, BBS5

Biological processes related to Learning Disability according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of uterine smooth muscle contractionGO:07047310.4ADRA2C, ADRA2A
2activation of MAPK activity by adrenergic receptor signaling pathwayGO:07188310.4ADRA2C, ADRA2A
3epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathwayGO:03562510.3ADRA2C, ADRA2A
4negative regulation of epinephrine secretionGO:03281110.3ADRA2A, ADRA2C
5activation of protein kinase B activityGO:03214810.3ADRA2C, ADRA2A
6muscle organ morphogenesisGO:04864410.1CNTF, TBX1
7negative regulation of norepinephrine secretionGO:01070010.0ADRA2C, ADRA2A

Molecular functions related to Learning Disability according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1epinephrine bindingGO:05137910.3ADRA2C, ADRA2A
2alpha2-adrenergic receptor activityGO:00493810.0ADRA2C, ADRA2A

Products for genes affiliated with Learning Disability

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Learning Disability

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet