MCID: LRN003
MIFTS: 62

Learning Disability malady

Fetal diseases category
Download this MalaCard

Summaries for Learning Disability

About this section
Sources:
8Disease Ontology, 34MedlinePlus, 44NINDS, 65Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard
MedlinePlus:34 Learning disorders affect how a person understands, remembers and responds to new information. people with learning disorders may have problems listening or paying attention speaking reading or writing doing math although learning disorders occur in very young children, they are usually not recognized until the child reaches school age. about one-third of children who have learning disabilities also have adhd, which makes it hard to focus. evaluation and testing by a trained professional can help identify a learning disorder. the next step is special education, which involves helping your child in the areas where he or she needs the most help. sometimes tutors or speech or language therapists also work with the children. learning disorders do not go away, but strategies to work around them can make them less of a problem. nih: national institute of neurological disorders and stroke

MalaCards: Learning Disability, also known as learning disorders, is related to mental retardation and neurofibromatosis. An important gene associated with Learning Disability is OMG (oligodendrocyte myelin glycoprotein), and among its related pathways are Neuroscience and Glioma. The compounds gelfoam and tecogalan sodium have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and breast, and related mouse phenotypes are hearing/vestibular/ear and liver/biliary system.

Disease Ontology:8 A specific developmental disorder that involves difficulty in scholastic skills such as reading, writing, spelling, reasoning, recalling and/or organizing information resulting from the brain's inability to receive and process information.

NINDS:44 Learning disabilities are disorders that affect the ability to understand or use spoken or written language, do mathematical calculations, coordinate movements, or direct attention. Although learning disabilities occur in very young children, the disorders are usually not recognized until the child reaches school age. Research shows that 8 to 10 percent of American children under 18 years of age have some type of learning disability.

Wikipedia:65 Learning disability is a classification including several areas of functioning in which a person has... more...

Aliases & Classifications for Learning Disability

About this section
Sources:
8Disease Ontology, 65Wikipedia, 22GTR, 44NINDS, 10DISEASES, 45Novoseek, 34MedlinePlus, 62UMLS, 35MeSH, 58SNOMED-CT
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases


Aliases & Descriptions:

learning disability 8 22 10
learning disorders 65 45 34 62
learning disabilities 44 62
academic skill disorder 8
learning disorder 8


External Ids:

Disease Ontology8 DOID:8927
MeSH35 D007859

Related Diseases for Learning Disability

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Learning Disability via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1069)
idRelated DiseaseScoreTop Affiliating Genes
1mental retardation30.5NF1, MAPT, MECP2, TSC1
2neurofibromatosis30.5NF1, OMG
3intellectual disability30.5MECP2, TSC1, PTCHD1
4tuberous sclerosis30.3TSC1, MECP2, NF1
5ischemia30.0PF4, PSAP, CNTF, MAPT, FGF2
6autistic disorder29.9CDH8, MECP2, TSC1
7moyamoya disease29.9NF1, FGF2
8hydrocephalus29.9TSC1, MAPT, NF1
9breast cancer29.6MYCN, TSC1, PSAP, MECP2, MAPT, NF1
10attention deficit hyperactivity disorder10.5
11schizophrenia10.4
12dyslexia10.3
13fragile x syndrome10.3
14asperger syndrome10.3
15cervicitis10.3
16turner syndrome10.3
17epilepsy, x-linked, with variable learning disabilities and behavior disorders10.3
18dyscalculia10.3
19neuronitis10.2
20autism spectrum disorder10.2
21obesity10.2
22brain injury10.2
23traumatic brain injury10.2
24dysgraphia10.2
25weaver syndrome10.2
26sotos syndrome10.2
27galactosemia10.2
28methylmalonic acidemia10.2
29personality disorder10.2
30goldberg-shprintzen megacolon syndrome10.2
31schindler disease, type 110.2
32shprintzen omphalocele syndrome10.2
33thanatophoric dysplasia type 110.2
34hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia10.2
353mc syndrome 110.1MASP1
36ganglioglioma10.1TSC1
37adrenal neuroblastoma10.1PHOX2B, MYCN
38infantile epileptic encephalopathy10.1TSC1, MECP2
39coffin-siris syndrome10.1
40bloom syndrome10.1
41klippel-trenaunay syndrome10.1
42renpenning syndrome10.1
43landau-kleffner syndrome10.1
44phenylketonuria10.1
45metachromatic leukodystrophy10.1
46cleft palate10.1
47developmental coordination disorder10.1
48prader-willi syndrome10.1
49cri-du-chat syndrome10.1
50incontinentia pigmenti achromians10.1

Graphical network of the top 20 diseases related to Learning Disability:



Diseases related to learning disability

Symptoms for Learning Disability

About this section

Drugs & Therapeutics for Learning Disability

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Learning Disability

Search NIH Clinical Center for Learning Disability

Genetic Tests for Learning Disability

About this section
Sources:
22GTR
See all sources

Genetic tests related to Learning Disability:

id Genetic test Affiliating Genes
1 Learning Disability22

Anatomical Context for Learning Disability

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Learning Disability:

33
Testes, Brain, Breast, Eye, Bone, Heart

Animal Models for Learning Disability or affiliated genes

About this section
Sources:
37MGI
See all sources

Publications for Learning Disability

About this section
Sources:
52PubMed
See all sources

Articles related to Learning Disability:

(show top 50)    (show all 528)
idTitleAuthorsYear
1
Managing eating and drinking difficulties (dysphagia) with children who have learning disabilities: What is effective? (24414040)
2014
2
Limited knowledge of fraction representations differentiates middle school students with mathematics learning disability (dyscalculia) versus low mathematics achievement. (23587941)
2013
3
Handedness and language learning disability differentially distribute in progressive aphasia variants. (24056533)
2013
4
Methylphenidate treatment of attention deficit hyperactivity disorder in young people with learning disability and difficult-to-treat epilepsy: Evidence of clinical benefit. (24304474)
2013
5
Estimating the severity of intellectual disability in adults: a Mokken scaling analysis of the learning disability screening questionnaire. (23544397)
2013
6
Mathematical difficulties in nonverbal learning disability or co-morbid dyscalculia and dyslexia. (23971493)
2013
7
Exemplar variability facilitates rapid learning of an otherwise unlearnable grammar by individuals with language-based learning disability. (22988285)
2013
8
Comparison of self-esteem and maternal attitude between children with learning disability and unaffected siblings. (23180409)
2013
9
End of life care for people with a learning disability. (23082363)
2012
10
Identity, emotion and the internal goods of practice: a study of learning disability professionals. (21668456)
2012
11
Adaptive behaviour in children and adolescents with foetal alcohol spectrum disorders: a comparison with specific learning disability and typical development. (22358422)
2012
12
POMHS 9b - antipsychotic prescribing in people with a learning disability. (21894103)
2011
13
A novel mutation in the HSD17B10 gene of a 10-year-old boy with refractory epilepsy, choreoathetosis and learning disability. (22132097)
2011
14
Improving recording of capacity to consent and explanation of medication side effects in a psychiatric service for people with learning disability: audit findings. (21750211)
2011
15
'It terrifies me, the thought of the future': listening to the current concerns of informal carers of people with a learning disability. (20630924)
2010
16
Processing prosodic structure by adults with language-based learning disability. (19324365)
2009
17
4.5 Mb microdeletion in chromosome band 2q33.1 associated with learning disability and cleft palate. (19576302)
2009
18
A review of mathematical learning disabilities in children with fragile X syndrome. (19213014)
2009
19
Drawing on three discursive modes in learning disability nurse education. (18829142)
2009
20
Dental Discomfort Questionnaire: its use with children with a learning disability. (18647374)
2008
21
Learning disability and the limits of liberal citizenship: interactional impediments to political empowerment. (17714342)
2007
22
Bilateral periventricular nodular heterotopia, severe learning disability, and epilepsy in a male patient with 46,XY,der(19)t(X;19) (q11.1-11.2;p13.3). (17355480)
2007
23
Mathematics learning disability in girls with Turner syndrome or fragile X syndrome. (16500739)
2006
24
A controlled study of anxiety and depression in mothers of children with learning disability in Lagos, Nigeria. (16805166)
2006
25
Disruption of a brain transcription factor, NPAS3, is associated with schizophrenia and learning disability. (15924306)
2005
26
Needs assessment in forensic learning disability. (15895641)
2005
27
Taurodontism and learning disabilities in patients with Klinefelter syndrome. (16435639)
2005
28
Improving primary care services for people with learning disability. (15658237)
2005
29
Forensic issues in learning disability. (16575790)
2004
30
Microarray based comparative genomic hybridisation (array-CGH) detects submicroscopic chromosomal deletions and duplications in patients with learning disability/mental retardation and dysmorphic features. (15060094)
2004
31
Making sense in a fragmentary world: communication in people with autism and learning disability. (15165435)
2004
32
Fine motor deficiencies in children with developmental coordination disorder and learning disabilities: an underlying open-loop control deficit. (14624830)
2003
33
Prevention in severe learning disability: lessons from a follow-up study of young adults with a history of childhood learning disability. (12898990)
2003
34
Interprofessional practice and learning disability nursing. (14688655)
2003
35
Quality of life as a concept for developing learning disability nursing practice? (12519251)
2003
36
Learning disability task force criticises draft mental health bill. (12549435)
2003
37
Adult outcome of childhood learning disability. (11570634)
2001
38
How does the severity of a learning disability affect working memory performance? (11594349)
2001
39
Behaviour modification and gentle teaching workshops: management of children with learning disabilities exhibiting challenging behaviour and implications for learning disability nursing. (11430611)
2001
40
An evaluation of community learning disability services for children with a learning disability. (12664722)
2001
41
Nurse networks in learning disability. (11968667)
2000
42
What definitions of learning disability say and don't say: a critical analysis. (15505963)
2000
43
Numerical and arithmetical cognition: a longitudinal study of process and concept deficits in children with learning disability. (11023658)
2000
44
Reducing antipsychotic medication in people with a learning disability. (10789325)
2000
45
Psychiatric illness and behavioural problems in adults with learning disability and epilepsy. (22387591)
1999
46
Assessing the ability of people with a learning disability to give informed consent to treatment. (10616942)
1999
47
Learning disability nursing. (10661193)
1999
48
Cervical screening for women with learning disability. Sefton has multidisciplinary group to promote sexual health care for these women. (10094543)
1999
49
Violence faced by staff in a learning disability service. (9548019)
1998
50
Learning disability and epilepsy. 2, a review of available outcome measures and position statement on development priorities. (9663797)
1997

Variations for Learning Disability

About this section

Expression for genes affiliated with Learning Disability

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Learning Disability

Search GEO for disease gene expression data for Learning Disability.

Pathways for genes affiliated with Learning Disability

About this section
Sources:
50PathCards, 5Cell Signaling Technology, 30KEGG, 38NCBI BioSystems Database, 53QIAGEN
See all sources

Pathways related to Learning Disability according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8MAPT, MECP2
2
Show member pathways
Signaling Pathways in Glioblastoma38
9.3FGF2, NF1, TSC1
3
Show member pathways
9.1FGF2, CDH8, MAPT, TSC1
4
Show member pathways
8.4PF4, TSC1, NF1, CDH8, FGF2

Compounds for genes affiliated with Learning Disability

About this section
Sources:
45Novoseek, 24HMDB, 11DrugBank, 29IUPHAR, 61Tocris Bioscience, 3BitterDB, 51PharmGKB
See all sources

Compounds related to Learning Disability according to GeneCards/GeneDecks:

(show all 27)
idCompoundScoreTop Affiliating Genes
1gelfoam4510.0MAPT, FGF2
2tecogalan sodium459.9FGF2, PF4
3protamine sulfate459.8PF4, FGF2
4bromodeoxyuridine459.8FGF2, CNTF, MYCN
5ganglioside459.8CNTF, PSAP, PF4
6guanosine45 24 1111.8TSC1, MECP2, NF1
7choline45 24 1111.7PSAP, CNTF, MAPT
8actinomycin d459.4MYCN, CNTF, MAPT, FGF2
9genistein45 29 61 3 24 1114.4FGF2, MAPT, CNTF, MYCN
10cytochalasin d45 6110.4FGF2, NF1, MAPT
11methionine459.4NF1, MAPT, CNTF, MECP2
12testosterone45 61 24 1112.3MAPT, CNTF, MECP2, PSAP
13heparan sulfate45 2410.3PF4, MAPT, FGF2
14nicotine45 29 51 1112.2PF4, MAPT, FGF2
15phosphatidylinositol459.1TSC1, PSAP, CNTF, NF1, FGF2
16nacl459.1NF1, MAPT, PSAP, PF4
17vegf459.1FGF2, CNTF, TSC1, MYCN, PF4
18cycloheximide459.1FGF2, MAPT, CNTF, MYCN
19agar459.0PF4, MYCN, FGF2
20paraffin458.9MYCN, TSC1, MAPT, NF1, FGF2
21glucose458.8MAPT, CNTF, PSAP, TSC1, PF4
22retinoic acid45 249.8FGF2, NF1, MAPT, CNTF, MYCN
23dopamine45 29 24 1111.6PF4, MYCN, CNTF, MAPT, NF1, PHOX2B
24arginine458.6PF4, PSAP, MECP2, CNTF, MAPT, NF1
25serine458.1MYCN, TSC1, PSAP, CNTF, MAPT, MASP1
26tyrosine458.1PF4, MYCN, TSC1, PSAP, CNTF, NF1
27alanine458.1FGF2, PF4, TSC1, MECP2, CNTF, MAPT

GO Terms for genes affiliated with Learning Disability

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Learning Disability according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.5FGF2, MASP1, CNTF, MECP2, PSAP, PF4

Biological processes related to Learning Disability according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1regulation of retinal cell programmed cell deathGO:04666810.1FGF2, CNTF
2regulation of respiratory gaseous exchange by neurological system processGO:00208710.1MECP2, PHOX2B
3startle responseGO:0019649.9NPAS3, MECP2
4glial cell differentiationGO:0100019.9FGF2, PHOX2B
5regulation of cell-matrix adhesionGO:0019529.9NF1, TSC1
6negative regulation of astrocyte differentiationGO:0487129.7NF1, MYCN
7sympathetic nervous system developmentGO:0484859.7PHOX2B, NF1
8cognitionGO:0508909.6NF1, PTCHD1
9regulation of angiogenesisGO:0457659.3FGF2, NF1

Products for genes affiliated with Learning Disability

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Learning Disability

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet