MCID: LRN003
MIFTS: 54

Learning Disability malady

Summaries for Learning Disability

Sources:
8Disease Ontology, 34MedlinePlus, 44NINDS, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Learning disorders affect how a person understands, remembers and responds to new information. people with learning disorders may have problems listening or paying attention speaking reading or writing doing math although learning disorders occur in very young children, they are usually not recognized until the child reaches school age. about one-third of children who have learning disabilities also have adhd, which makes it hard to focus. evaluation and testing by a trained professional can help identify a learning disorder. the next step is special education, which involves helping your child in the areas where he or she needs the most help. sometimes tutors or speech or language therapists also work with the children. learning disorders do not go away, but strategies to work around them can make them less of a problem. nih: national institute of neurological disorders and stroke

MalaCards: Learning Disability, also known as learning disorders, is related to attention deficit hyperactivity disorder and acrocephalosyndactylia. An important gene associated with Learning Disability is TTC8 (tetratricopeptide repeat domain 8), and among its related pathways are Adrenoceptors and Integrin alphaIIb beta3 signaling. The compounds [3h]rx821002 and jp 1302 dihydrochloride have been mentioned in the context of this disorder. Related mouse phenotype embryogenesis.

Disease Ontology:8 A specific developmental disorder that involves difficulty in scholastic skills such as reading, writing, spelling, reasoning, recalling and/or organizing information resulting from the brain's inability to receive and process information.

NINDS:44 Learning disabilities are disorders that affect the ability to understand or use spoken or written language, do mathematical calculations, coordinate movements, or direct attention. Although learning disabilities occur in very young children, the disorders are usually not recognized until the child reaches school age. Research shows that 8 to 10 percent of American children under 18 years of age have some type of learning disability.

Wikipedia:64 Learning disability is a classification including several areas of functioning in which a person has... more...

Aliases & Classifications for Learning Disability

Sources:
8Disease Ontology, 22GTR, 10DISEASES, 64Wikipedia, 45Novoseek, 34MedlinePlus, 61UMLS, 44NINDS, 57SNOMED-CT, 35MeSH
See all sources

Aliases & Descriptions:

learning disability 8 22 10
learning disorders 64 45 34 61
learning disabilities 44 61
academic skill disorder 8
learning disorder 8


External Ids:

Disease Ontology8 DOID:8927
MeSH35 D007859

Related Diseases for Learning Disability

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Learning Disability via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1042)
idRelated DiseaseScoreTop Affiliating Genes
1attention deficit hyperactivity disorder30.6ADRA2C, ADRA2A, IMPACT
2acrocephalosyndactylia29.8TWISTNB, FERD3L
3n syndrome10.5
4asperger syndrome10.4
5mental retardation10.4
6dyslexia10.3
7neurofibromatosis10.3
8turner syndrome10.3
9epilepsy, x-linked, with variable learning disabilities and behavior disorders10.3
10dyscalculia10.2
11sotos syndrome10.2
12fragile x syndrome10.2
13autism spectrum disorder10.2
14char syndrome10.2
15brain injury10.2
16traumatic brain injury10.2
17silver-russell syndrome10.1
18weaver syndrome10.1
19tuberous sclerosis10.1
20dysgraphia10.1
21developmental disabilities10.1
22schindler disease, type 110.1
23goldberg-shprintzen megacolon syndrome10.1
24shprintzen omphalocele syndrome10.1
25thanatophoric dysplasia type 110.1
26hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia10.1
27klippel-trenaunay syndrome10.1
28bloom syndrome10.1
29coffin-siris syndrome10.1
30incontinentia pigmenti achromians10.1
31autistic disorder10.1
32metachromatic leukodystrophy10.1
33landau-kleffner syndrome10.1
34phenylketonuria10.1
35renpenning syndrome10.1
36cleft palate10.1
37developmental coordination disorder10.1
38prader-willi syndrome10.1
39aphasia10.1
40bipolar disorder10.1
41mecp2 duplication syndrome10.1
42spastic paraplegia 110.1
43oculofaciocardiodental syndrome10.1
44feingold syndrome10.1
45cardiocranial syndrome10.1
46cat eye syndrome10.1
47cockayne syndrome type ii10.1
48sialidosis type i10.1
49chromosome 22q deletion10.1
50septo-optic dysplasia10.1

Graphical network of the top 20 diseases related to Learning Disability:



Diseases related to learning disability

Clinical Features for Learning Disability

Drugs & Therapeutics for Learning Disability

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Learning Disability

Drug clinical trials:

Search ClinicalTrials for Learning Disability

Search NIH Clinical Center for Learning Disability

Search CenterWatch for Learning Disability

Genetic Tests for Learning Disability

Sources:
22GTR
See all sources

Genetic tests related to Learning Disability:

id Genetic test Affiliating Genes
1 Learning Disability22

Anatomical Context for Learning Disability

Animal Models for Learning Disability or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Learning Disability:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053809.6GSC2, ADRA2C, ADRA2A, TBX1, PHOX2B, FERD3L

Publications for Learning Disability

Sources:
51PubMed
See all sources

Articles related to Learning Disability:

(show top 50)    (show all 502)
idTitleAuthorsYear
1
Do individuals with intellectual disability select appropriate objects as landmarks when learning a new route? (23228196)
2013
2
Smaller splenium in children with nonverbal learning disability compared to controls, high-functioning autism and ADHD. (24215424)
2013
3
Sporting for people with a learning disability. (23123653)
2012
4
Competence-based education: learning disability nursing in Wales. (23243819)
2012
5
Quantifying emergency department admission rates for people with a learning disability. (21478412)
2012
6
Primary nocturnal enuresis and learning disability. (21487372)
2011
7
A new autosomal dominant syndrome of distinctive face showing ptosis and prominent eyes associated with cleft palate, ear anomalies, and learning disability. (21834043)
2011
8
'It terrifies me, the thought of the future': listening to the current concerns of informal carers of people with a learning disability. (20630924)
2010
9
The Regression-Based Discrepancy Definition of Learning Disability: A Critical Appraisal. (20375287)
2010
10
Futures planning, parental expectations and sibling concern for people who have a learning disability. (21062855)
2010
11
The impact of social policy on changes in professional practice within learning disability services: different standards for children and adults? A two-part examination: Part 1. The policy foundations: from welfare markets to Valuing People, personalization and Baby P. (21285124)
2010
12
Processing prosodic structure by adults with language-based learning disability. (19324365)
2009
13
Current perceptions of respite care: experiences of family and informal carers of people with a learning disability. (20048347)
2009
14
The size, extent and nature of the learning disability nursing research base: a systematic scoping review. (18842263)
2009
15
People with a learning disability and dysphagia: a cinderella population? (18516639)
2009
16
Impact of attention-deficit/hyperactivity disorder on health-related quality-of-l ife of specific learning disability children [corrected]. (20012790)
2009
17
Learning disability education in the common foundation programme. (19685677)
2009
18
Dental Discomfort Questionnaire: its use with children with a learning disability. (18647374)
2008
19
Expressed emotion and burnout: the experience of staff caring for men with learning disability and psychosis in a medium secure setting. (17430450)
2007
20
Auditory processing disorder in children diagnosed with nonverbal learning disability. (17182875)
2006
21
Scope for more genetic testing in learning disability. Case report of an inherited duplication on the X-chromosome. (16880477)
2006
22
The mental health needs of people with a learning disability detained in police custody. (16683465)
2006
23
Processing abilities associated with math skills in adult learning disability. (16448977)
2006
24
Safety of learning disability patients must be improved. (15156855)
2004
25
Antipsychotic medication versus placebo for people with both schizophrenia and learning disability. (15494985)
2004
26
The discursive practice of learning disability: Implications for instruction and parent-school relations. (15586465)
2004
27
When Asperger's syndrome and a nonverbal learning disability look alike. (15502535)
2004
28
Attention deficit hyperactivity disorder: review of ADHD in learning disability: the Diagnostic Criteria for Psychiatric Disorders for Use with Adults with Learning Disabilities/Mental Retardation[DC-LD] criteria for diagnosis. (14516370)
2003
29
Development and psychometric properties of the Glasgow Depression Scale for people with a Learning Disability. Individual and carer supplement versions. (12668412)
2003
30
Learning disability. (13678878)
2003
31
Learning disability subtypes and the role of attention during the naming of pictures and words: an event-related potential analysis. (12740189)
2003
32
Primary health care provision for adults with a learning disability. (12752886)
2003
33
Learning disability subtypes: classification of high functioning hyperlexia. (12174811)
2002
34
A study to determine the qualities of a learning disability practitioner. (12514472)
2002
35
Sexual abuse and learning disability. (16259824)
2002
36
Health facilitation in learning disability: a new specialist role. (12048456)
2002
37
Dysmorphic features and learning disability in an adult male with pure partial trisomy 17q24-q25 due to a terminal duplication. (12244560)
2002
38
Pica with learning disability. (11773354)
2002
39
Adult outcome of childhood learning disability. (11570634)
2001
40
How does the severity of a learning disability affect working memory performance? (11594349)
2001
41
Antipsychotic medication for those with both schizophrenia and learning disability. (11279675)
2001
42
Poverty as a practice issue for learning disability nurses. (11893957)
2001
43
Evidence-based prescribing in adults with learning disability and epilepsy. (11422357)
2001
44
What definitions of learning disability say and don't say: a critical analysis. (15505963)
2000
45
Use of psychotropic medication in people with a learning disability. (11261057)
2000
46
One from the heart for people with a learning disability. (10214139)
1999
47
Korean red ginseng saponins with low ratios of protopanaxadiol and protopanaxatriol saponin improve scopolamine-induced learning disability and spatial working memory in mice. (10433468)
1999
48
Gross deletions of the neurofibromatosis type 1 (NF1) gene are predominantly of maternal origin and commonly associated with a learning disability, dysmorphic features and developmental delay. (9654211)
1998
49
Normal adaptive function with learning disability in duplication 8p including band p22. (9674899)
1998
50
Learning disability care staff's emotional reactions to aggressive challenging behaviours: development of a measurement tool. (9856297)
1998

Genetic Variations for Learning Disability

Expression for genes affiliated with Learning Disability

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Learning Disability

Search GEO for disease gene expression data for Learning Disability.

Pathways for genes affiliated with Learning Disability

Sources:
54Reactome, 50PharmGKB
See all sources

Pathways related to Learning Disability according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3ADRA2C, ADRA2A
2
Hide members
10.3ADRA2C, ADRA2A

Compounds for genes affiliated with Learning Disability

Sources:
29IUPHAR, 60Tocris Bioscience, 11DrugBank, 45Novoseek, 50PharmGKB, 24HMDB
See all sources

Compounds related to Learning Disability according to GeneCards/GeneDecks:

(show all 45)
idCompoundScoreTop Affiliating Genes
1[3h]rx8210022910.7ADRA2C, ADRA2A
2jp 1302 dihydrochloride6010.7ADRA2A, ADRA2C
3medetomidine hydrochloride6010.7ADRA2C, ADRA2A
4brl 44408 maleate6010.7ADRA2A, ADRA2C
5[3h]mk-9122910.7ADRA2C, ADRA2A
6rx8210022910.7ADRA2C, ADRA2A
7brl 444082910.7ADRA2A, ADRA2C
8arc-2392910.7ADRA2C, ADRA2A
9atipamezole hydrochloride6010.7ADRA2A, ADRA2C
10dexmedetomidine hydrochloride6010.7ADRA2A, ADRA2C
11Bethanidine1110.7ADRA2A, ADRA2C
12[3h]rauwolscine2910.7ADRA2A, ADRA2C
13xylazine29 4511.7ADRA2C, ADRA2A
14tizanidine45 1111.7ADRA2C, ADRA2A
15Xylometazoline1110.6ADRA2A, ADRA2C
16guanfacine29 45 1112.6ADRA2A, ADRA2C
17wb 41012910.6ADRA2A, ADRA2C
18Lurasidone1110.6ADRA2A, ADRA2C
19rauwolscine2910.6ADRA2A, ADRA2C
20(-)-noradrenaline2910.6ADRA2A, ADRA2C
21piribedil29 4511.6ADRA2A, ADRA2C
22dexmedetomidine29 45 1112.6ADRA2A, ADRA2C
23spiroxatrine29 4511.6ADRA2A, ADRA2C
24oxymetazoline29 45 1112.6ADRA2A, ADRA2C
25fenoldopam45 1111.6ADRA2C, ADRA2A
26brimonidine29 45 1112.6ADRA2A, ADRA2C
27phenoxybenzamine45 1111.6ADRA2C, ADRA2A
28Droxidopa1110.5ADRA2C, ADRA2A
29Ephedra1110.5ADRA2C, ADRA2A
30terguride29 4511.5ADRA2A, ADRA2C
31methamphetamine45 50 1112.5ADRA2A, ADRA2C, CNTF
32phentolamine29 45 1112.5ADRA2A, ADRA2C
33ropinirole45 1111.5ADRA2A, ADRA2C
34lisuride29 45 1112.5ADRA2C, ADRA2A
35pergolide29 45 1112.4ADRA2A, ADRA2C
36Dronedarone1110.4ADRA2A, ADRA2C
37catecholamine4510.4ADRA2C, CNTF, ADRA2A
38paliperidone45 1111.4ADRA2C, ADRA2A
39pramipexole45 50 29 1113.3ADRA2C, ADRA2A
40norepinephrine45 11 2412.3ADRA2C, PHOX2B, CNTF, PF4, ADRA2A
41Methotrimeprazine1110.3ADRA2A, ADRA2C
42doxepin45 29 50 1113.3ADRA2A, ADRA2C
43dopamine45 29 11 2413.2ADRA2C, PHOX2B, CNTF, PF4, ADRA2A
44asenapine29 1111.2ADRA2C, ADRA2A
45cabergoline29 45 1112.0ADRA2A, ADRA2C

GO Terms for genes affiliated with Learning Disability

Sources:
16Gene Ontology
See all sources

Cellular components related to Learning Disability according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1BBSomeGO:03446410.3TTC8, BBS5

Biological processes related to Learning Disability according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of uterine smooth muscle contractionGO:07047310.4ADRA2A, ADRA2C
2activation of MAPK activity by adrenergic receptor signaling pathwayGO:07188310.4ADRA2A, ADRA2C
3epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathwayGO:03562510.3ADRA2A, ADRA2C
4negative regulation of epinephrine secretionGO:03281110.3ADRA2A, ADRA2C
5activation of protein kinase B activityGO:03214810.3ADRA2A, ADRA2C
6muscle organ morphogenesisGO:04864410.1CNTF, TBX1
7negative regulation of norepinephrine secretionGO:01070010.0ADRA2A, ADRA2C

Molecular functions related to Learning Disability according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1epinephrine bindingGO:05137910.3ADRA2C, ADRA2A
2alpha2-adrenergic receptor activityGO:00493810.0ADRA2C, ADRA2A

Products for genes affiliated with Learning Disability

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Learning Disability

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet