MCID: LCH001
MIFTS: 43

Leech Infestation

Categories: Infectious diseases

Aliases & Classifications for Leech Infestation

MalaCards integrated aliases for Leech Infestation:

Name: Leech Infestation 12 14 69
Hirudiniasis 12
Leeches 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11079
ICD10 32 B88.3
ICD9CM 34 134.2
UMLS 69 C0019575

Summaries for Leech Infestation

Disease Ontology : 12 A parasitic ectoparasitic infectious disease that involves parasitic infestation by members of the subclass Hirudinea. The leeches remain attached to their hosts and feed on blood until they become full, at which point they fall off to digest. While feeding, they release an anesthetic and use a combination of mucus and suction to stay attached and secrete an anti-clotting enzyme, hirudin, into the host's blood stream.

MalaCards based summary : Leech Infestation, also known as hirudiniasis, is related to boomerang dysplasia and intracranial sinus thrombosis. An important gene associated with Leech Infestation is SERPINC1 (Serpin Family C Member 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Aztreonam and Sodium oxybate have been mentioned in the context of this disorder. Affiliated tissues include heart and eye, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 72 Leeches are segmented worms that belong to the phylum Annelida and comprise the subclass Hirudinea. Like... more...

Related Diseases for Leech Infestation

Diseases related to Leech Infestation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 147)
# Related Disease Score Top Affiliating Genes
1 boomerang dysplasia 10.4 FLNA SERPINC1
2 intracranial sinus thrombosis 10.4 F3 SERPINC1
3 angina pectoris 10.3 F3 SERPINC1
4 acquired hemophilia 10.3 F10 F3
5 intracranial thrombosis 10.3 F3 SERPINC1
6 factor xii deficiency 10.3 F3 SERPINC1
7 carotid artery thrombosis 10.3 F10 F3
8 coronary thrombosis 10.3 F3 SERPINC1
9 japanese spotted fever 10.3 KANTR SERPINC1
10 posterior myocardial infarction 10.3 KANTR SERPINC1
11 senile entropion 10.3 FLNA KANTR
12 pulmonary immaturity 10.3 F3 SERPINC1
13 hemophilia a 10.3 F10 F3
14 paraphimosis 10.3 FLNA KANTR
15 spinal cord infarction 10.2 F2 SERPINC1
16 conjugate gaze palsy 10.2 F3 PLG
17 sudden sensorineural hearing loss 10.2 F2 SERPINC1
18 blood protein disease 10.2 F2 SERPINC1
19 ischemic colitis 10.2 F2 SERPINC1
20 subdural empyema 10.2 FLNA KANTR
21 dysbaric osteonecrosis 10.2 F3 PLG
22 sneddon syndrome 10.2 F2 SERPINC1
23 retinal artery occlusion 10.2 F2 SERPINC1
24 esophageal varix 10.2 F2 SERPINC1
25 hemometra 10.2 F3 KANTR
26 urethral calculus 10.2 F2 FLNA
27 thrombophlebitis 10.2 F2 SERPINC1
28 acute anterolateral myocardial infarction 10.2 KANTR PLG
29 posterolateral myocardial infarction 10.2 KANTR PLG
30 facial neuralgia 10.2 KANTR PLG
31 lemierre's syndrome 10.2 F3 PLG
32 post-thrombotic syndrome 10.2 F2 SERPINC1
33 vaginitis 10.2
34 hypersplenism 10.2 F2 SERPINC1
35 vertebral artery occlusion 10.2 F3 PLG
36 apical myocardial infarction 10.2 KANTR PLG
37 taylor's syndrome 10.2 F2 FLNA
38 cerebral arteritis 10.2 KANTR PLG
39 central retinal vein occlusion 10.2 F2 SERPINC1
40 alveolar periostitis 10.2 KANTR PLG
41 lower urinary tract calculus 10.2 F2 FLNA
42 cardiovascular organ benign neoplasm 10.2 FLNA KANTR
43 shwartzman phenomenon 10.2 F3 KANTR
44 benign perivascular tumor 10.2 FLNA KANTR
45 anteroseptal myocardial infarction 10.2 KANTR PLG
46 placenta disease 10.2 F3 SERPINC1
47 cerebral sinovenous thrombosis 10.1 F2 F3
48 von willebrand disease, type 1 10.1 F2 F3
49 brown-sequard syndrome 10.1 KANTR PLG
50 portal vein thrombosis 10.1 F2 SERPINC1

Graphical network of the top 20 diseases related to Leech Infestation:



Diseases related to Leech Infestation

Symptoms & Phenotypes for Leech Infestation

MGI Mouse Phenotypes related to Leech Infestation:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.91 FLNA JAK1 PLG F10 F2 SERPINC1
2 hematopoietic system MP:0005397 9.8 F3 FLNA JAK1 PLG F2 SERPINC1
3 homeostasis/metabolism MP:0005376 9.8 FLNA JAK1 PLG F10 F2 SERPINC1
4 immune system MP:0005387 9.63 F3 FLNA JAK1 PLG F2 SERPINC1
5 mortality/aging MP:0010768 9.5 F3 FLNA JAK1 PLG F10 F2
6 respiratory system MP:0005388 9.02 FLNA JAK1 PLG F2 F3

Drugs & Therapeutics for Leech Infestation

Drugs for Leech Infestation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 68)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aztreonam Approved Phase 3 78110-38-0 5742832 5362041
2
Sodium oxybate Approved Phase 3 502-85-2 5360545
3 Vaccines Phase 3,Phase 1,Phase 2
4 Anti-Bacterial Agents Phase 3
5 Antibiotics, Antitubercular Phase 3
6 Pharmaceutical Solutions Phase 3,Phase 2
7 Adjuvants, Anesthesia Phase 3
8 Anesthetics Phase 3
9 Anesthetics, General Phase 3
10 Anesthetics, Intravenous Phase 3
11 Central Nervous System Depressants Phase 3
12
Aluminum hydroxide Approved, Investigational Phase 1, Phase 2 21645-51-2
13
Formaldehyde Approved, Vet_approved Phase 1, Phase 2 50-00-0 712
14 Adjuvants, Immunologic Phase 1, Phase 2
15 Antacids Phase 1, Phase 2
16 Anti-Infective Agents Phase 1, Phase 2
17 Anti-Ulcer Agents Phase 1, Phase 2
18 Disinfectants Phase 1, Phase 2
19 Gastrointestinal Agents Phase 1, Phase 2
20
Protein C Approved Phase 1
21
Aluminum sulfate Approved Phase 1 10043-01-3
22 Drotrecogin alfa activated Phase 1
23
Aspirin Approved, Vet_approved Early Phase 1 50-78-2 2244
24
Metoprolol Approved, Investigational Early Phase 1 51384-51-1, 37350-58-6 4171
25
Ramipril Approved Early Phase 1 87333-19-5 5362129
26
Cyclophosphamide Approved, Investigational 50-18-0, 6055-19-2 2907
27
Tacrolimus Approved, Investigational 104987-11-3 445643 439492
28
Norepinephrine Approved 51-41-2 439260
29
Diclofenac Approved, Vet_approved 15307-86-5 3033
30 Adrenergic Agents Early Phase 1
31 Adrenergic Antagonists Early Phase 1
32 Adrenergic beta-1 Receptor Antagonists Early Phase 1
33 Adrenergic beta-Antagonists Early Phase 1
34 Angiotensin-Converting Enzyme Inhibitors Early Phase 1
35 Anti-Arrhythmia Agents Early Phase 1
36 Anticholesteremic Agents Early Phase 1
37 Antihypertensive Agents Early Phase 1
38 Antimetabolites Early Phase 1
39 Atorvastatin Calcium Early Phase 1 134523-03-8
40 Autonomic Agents Early Phase 1
41 Calcium, Dietary Early Phase 1
42 HIV Protease Inhibitors Early Phase 1
43 Hydroxymethylglutaryl-CoA Reductase Inhibitors Early Phase 1
44 Hypolipidemic Agents Early Phase 1
45 Lipid Regulating Agents Early Phase 1
46 Neurotransmitter Agents Early Phase 1
47 Peripheral Nervous System Agents Early Phase 1
48
protease inhibitors Early Phase 1
49 Sympatholytics Early Phase 1
50 Alkylating Agents

Interventional clinical trials:

(show all 21)

# Name Status NCT ID Phase Drugs
1 Role of Sleep Apnea and Sympathetic Activity in Resistant Hypertensive Patients. Completed NCT01875341 Phase 3
2 Adult Safety Study of 2009/2010 Seasonal Influenza Vaccine Completed NCT01063088 Phase 3
3 Safety and Effectiveness of AZLI (an Inhaled Antibiotic) in Adults With Non-Cystic Fibrosis Bronchiectasis Completed NCT01314716 Phase 3 AZLI;Placebo
4 Extension of Study TKT024 Evaluating Long-Term Safety and Clinical Outcomes in MPS II Patients Receiving Idursulfase Completed NCT00630747 Phase 2, Phase 3
5 Sodium Oxybate for Treatment of Excessive Daytime Sleepiness and Cataplexy in Narcolepsy Recruiting NCT02720744 Phase 3 Sodium Oxybate;Placebo
6 Clinical Evaluation of Leech Therapy in the Treatment of Knee Osteoarthritis Completed NCT02612974 Phase 2
7 Leeches for the Treatment of Knee Osteoarthritis Completed NCT00435773 Phase 2
8 Open-label Study to Assess Immunogenicity and Safety of a Vaccine Enhancement Patch When Administered With 2 Doses of H5N1 Vaccine Completed NCT01353534 Phase 1, Phase 2 Vaccine Enhancement Patch
9 A/H1N1 Immunogenicity and Safety in Adults Completed NCT00959465 Phase 1, Phase 2
10 Safety and Immunogenicity Study of a Ross River Virus (RRV) Vaccine Completed NCT00717834 Phase 1, Phase 2
11 Safety and Pharmacokinetics of Single and Multiple Ascending Doses of 3K3A-APC in Healthy Adult Volunteers Completed NCT01660230 Phase 1 0.9% NaCl in water
12 An Open-label Study Assessing Safety, Immunogenicity and Dose Response of IC84 Completed NCT01296386 Phase 1
13 Acupoint Application in Patients With Stable Angina Pectoris (AASAP) Unknown status NCT02029118 Early Phase 1 Herbal plaster ( styrax, borneol, frankincense, santalum,trichosanthes kirilowii Maxim, allium macrostemon Bunge, leech);Aspirin: 100mg qd; Metoprolol´╝Ü25mg bid; Ramipril:5mg qd; Atorvastatin:20mg qn.
14 Study on Single-nucleotide-polymorphism in Idiopathic Membranous Nephropathy Unknown status NCT01799460 The Comprehensive Treatment Regimen of Traditional Chinese Medicine;The immunosuppressive agents
15 RISA Extension Study - Long Term Safety Unknown status NCT00401986
16 Comprehensive Nano - PMCF Study Recruiting NCT03423953
17 ASV Effects on Myocardial Energetics and Sympathetic Nerve Function in Heart Failure and Sleep Apnea. Recruiting NCT02116140
18 The National Myelodysplastic Syndromes (MDS) Study Recruiting NCT02775383
19 Pulmonary Embolism Short-term Clinical Outcomes Registry Recruiting NCT02883491
20 Effectiveness and Safety of Breeded Leech for Symptomatic Primary Arthrosis of the First Carpometacarpal Joint Active, not recruiting NCT03020368 Diclofenac
21 Leech Therapy for Postherpetic Neuralgia Terminated NCT01744522

Search NIH Clinical Center for Leech Infestation

Genetic Tests for Leech Infestation

Anatomical Context for Leech Infestation

MalaCards organs/tissues related to Leech Infestation:

38
Heart, Eye

Publications for Leech Infestation

Articles related to Leech Infestation:

(show all 45)
# Title Authors Year
1
Severe anemia due to pharyngeal leech infestation; aA case report from Ethiopia. ( 29025407 )
2017
2
Bronchial Leech Infestation in a 15-Year-Old Female. ( 27752380 )
2016
3
Upper airway obstruction and hemoptysis due to a leech infestation in a child. ( 26655785 )
2016
4
Epistaxis Due to Leech Infestation in Nose: A Report of Six Cases and Review of Literature. ( 27066409 )
2016
5
Ocular leech infestation. ( 25784786 )
2015
6
Vaginal Leech Infestation: A Rare Cause of Hypovolumic Shock In Postmenopausal Woman. ( 26949304 )
2015
7
An Unusual Cause of Bleeding on the Floor of Mouth: Leech Infestation. ( 26809923 )
2015
8
Mass leech infestation of sculpin fish in Lake Baikal, with clarification of disease-prone species and parasite taxonomy. ( 25004101 )
2014
9
A rare case report of tracheal leech infestation in a 40-year-old woman. ( 25419405 )
2014
10
Leech Infestation in the Vulvar Region: A Possibility to be Considered. ( 25709802 )
2014
11
Ocular leech infestation initially misdiagnosed as conjunctival pigmented nevus. ( 23991397 )
2013
12
Leech infestation: the unusual cause of upper airway obstruction. ( 23559840 )
2013
13
Leech infestation in children through body orifices: experience in a hospital in Bangladesh. ( 22543722 )
2012
14
Eye bleeding due to leech infestation in an ischemic heart- disease patient. ( 22754689 )
2012
15
Intermittent gastrointestinal bleeding in a child: leech infestation. ( 23429838 )
2012
16
Nasal leech infestation causing persistent epistaxis. ( 21887037 )
2011
17
Ocular leech infestation. ( 20804315 )
2010
18
Oropharyngeal leech infestation and therapeutic options. ( 21391194 )
2010
19
Nasal leech infestation: report of seven leeches and literature review. ( 20037786 )
2010
20
Nasal leech infestation in children: comparison of two different innovative techniques. ( 19395059 )
2009
21
An unusual cause of gastrointestinal bleeding and severe anemia in a child: leech infestation. ( 19264837 )
2009
22
Unusual cause of unilateral epistaxis: nasal leech infestation. ( 18552891 )
2008
23
A case series of bleeding due to Leech infestation from the Gimbie region, Ethiopia. ( 18302875 )
2008
24
Leech infestation and its association with water drinking habits. ( 16542595 )
2006
25
A case of conjunctival leech infestation. ( 16453190 )
2006
26
Adult ocular leech infestation. ( 15832186 )
2006
27
Aquatic leech infestation: a rare cause of severe anaemia in an adolescent Tanzanian girl. ( 15346909 )
2004
28
The influence of agricultural and urban contamination on leech infestation of freshwater turtles, Phrynops geoffroanus, taken from two areas of the Uberabinha River. ( 15327164 )
2004
29
Unexpected result in the etiological approaching to an anemic case: a leech infestation. ( 12959860 )
2003
30
Leech infestation as a potential cause of hemoptysis in childhood. ( 11784268 )
2002
31
Leech infestation: an unusual cause of hoarseness. ( 11991029 )
2002
32
Ocular leech infestation in a child. ( 9222244 )
1997
33
Post menopausal vaginal bleeding due to vaginal wall leech infestation. ( 8674494 )
1995
34
Post menopausal vaginal bleeding due to vaginal wall leech infestation. ( 7588657 )
1995
35
Haematemesis due to leech infestation. ( 1694646 )
1990
36
Leech infestation of livestock. ( 2773211 )
1989
37
Leech infestation of mute swans (Cygnus olor) ( 2718339 )
1989
38
Tails of the unexpectorated: experiences with leech infestation in childhood. ( 2449848 )
1987
39
Leech infestation of man in Al-Taif, Saudi Arabia. ( 3693958 )
1987
40
Nasal leech infestation of man. ( 3603699 )
1987
41
Correlation of leech infestation and eosinophilia in alligators. ( 448620 )
1979
42
Leech infestation of man in Rhodesia. ( 860320 )
1977
43
Nasal leech infestation in man. ( 5493048 )
1970
44
Nasal leech infestation in the rhesus monkey. ( 4249653 )
1970
45
Further note on leech infestation in man. ( 18119173 )
1949

Variations for Leech Infestation

Expression for Leech Infestation

Search GEO for disease gene expression data for Leech Infestation.

Pathways for Leech Infestation

Pathways related to Leech Infestation according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.78 F10 F2 F3 FLNA JAK1 PLG
2
Show member pathways
12.34 F10 F2 F3 SERPINC1
3
Show member pathways
12.14 F2 JAK1 PLG
4
Show member pathways
11.56 F10 F2 F3 PLG SERPINC1
5 11.16 F10 F2 F3 PLG SERPINC1
6 10.9 F2 PLG
7 10.69 F2 PLG
8 10.43 F10 F2

GO Terms for Leech Infestation

Cellular components related to Leech Infestation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.43 F10 F2 SERPINC1
2 extracellular region GO:0005576 9.43 F10 F2 F3 FLNA PLG SERPINC1
3 blood microparticle GO:0072562 9.33 F2 PLG SERPINC1
4 intrinsic component of external side of plasma membrane GO:0031233 8.62 F10 F3

Biological processes related to Leech Infestation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.65 F2 PLG SERPINC1
2 regulation of blood coagulation GO:0030193 9.46 F2 SERPINC1
3 fibrinolysis GO:0042730 9.43 F2 PLG
4 signal peptide processing GO:0006465 9.4 F10 F2
5 blood coagulation, intrinsic pathway GO:0007597 9.37 F10 F2
6 blood coagulation GO:0007596 9.35 F10 F2 F3 PLG SERPINC1
7 peptidyl-glutamic acid carboxylation GO:0017187 9.32 F10 F2
8 negative regulation of fibrinolysis GO:0051918 9.26 F2 PLG
9 blood coagulation, extrinsic pathway GO:0007598 9.16 F10 F3
10 hemostasis GO:0007599 9.02 F10 F2 F3 PLG SERPINC1

Molecular functions related to Leech Infestation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type peptidase activity GO:0008236 9.13 F10 F2 PLG
2 serine-type endopeptidase activity GO:0004252 8.92 F10 F2 F3 PLG

Sources for Leech Infestation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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