MCID: LCH001
MIFTS: 40

Leech Infestation malady

Categories: Infectious diseases

Aliases & Classifications for Leech Infestation

Aliases & Descriptions for Leech Infestation:

Name: Leech Infestation 12 14 69
Hirudiniasis 12
Leeches 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11079
ICD10 33 B88.3
ICD9CM 35 134.2
UMLS 69 C0019575

Summaries for Leech Infestation

Disease Ontology : 12 A parasitic ectoparasitic infectious disease that involves parasitic infestation by members of the subclass Hirudinea. The leeches remain attached to their hosts and feed on blood until they become full, at which point they fall off to digest. While feeding, they release an anesthetic and use a combination of mucus and suction to stay attached and secrete an anti-clotting enzyme, hirudin, into the host's blood stream.

MalaCards based summary : Leech Infestation, also known as hirudiniasis, is related to heart disease and hypogonadotropic hypogonadism 18 with or without anosmia. An important gene associated with Leech Infestation is SERPINC1 (Serpin Family C Member 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Aztreonam and Sodium oxybate have been mentioned in the context of this disorder. Affiliated tissues include heart and eye, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 71 Leeches are segmented worms that belong to the phylum Annelida and comprise the subclass Hirudinea. Like... more...

Related Diseases for Leech Infestation

Diseases related to Leech Infestation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 137)
id Related Disease Score Top Affiliating Genes
1 heart disease 29.8 FLNA KANTR
2 hypogonadotropic hypogonadism 18 with or without anosmia 10.2 FLNA SERPINC1
3 sertoli cell tumor 10.2 F3 SERPINC1
4 hypertrichosis 10.2 F3 SERPINC1
5 acrodysplasia scoliosis 10.2 F10 F3
6 neuronopathy, distal hereditary motor, type iid 10.2 F3 SERPINC1
7 secretory diarrhea myopathy and deafness 10.2 F3 SERPINC1
8 vascular erectile tumor 10.2 F2 SERPINC1
9 subclavian artery aneurysm 10.2 F10 F3
10 peanut allergy 10.2 F2 SERPINC1
11 may-hegglin anomaly 10.2 F2 SERPINC1
12 conjunctivochalasis 10.2 F3 SERPINC1
13 monocular exotropia 10.2 F3 SERPINC1
14 left-right axis malformations 10.2 F2 SERPINC1
15 lymphocytic colitis 10.2 F2 SERPINC1
16 bullous skin disease 10.2 F2 SERPINC1
17 neuroaxonal dystrophy 10.2 F2 SERPINC1
18 cerebellar astrocytoma 10.2 F2 SERPINC1
19 ischemic fasciitis 10.2 F2 FLNA
20 angelucci's syndrome 10.2 F2 SERPINC1
21 lynch syndrome 10.2 F2 SERPINC1
22 glaucomatocyclitic crisis 10.2 F2 FLNA
23 cryptosporidiosis 10.2 F2 SERPINC1
24 lupus erythematosus 10.2 F3 SERPINC1
25 sulfhemoglobinemia 10.2 F3 PLG
26 angular blepharoconjunctivitis 10.2 F2 SERPINC1
27 septic myocarditis 10.2 F3 SERPINC1
28 ovarian papillary cystadenoma 10.2 F2 SERPINC1
29 alpha-2-macroglobulin deficiency 10.2 F2 F3
30 hendra virus infection 10.2 F2 F3
31 prostatic hypertrophy 10.2 F2 F3
32 eagle syndrome 10.2 F2 SERPINC1
33 dyskinetic cerebral palsy 10.2 F2 F3
34 stroke, ischemic 10.2 F2 F3
35 intravascular fasciitis 10.2 F2 FLNA
36 dysgammaglobulinemia 10.2 F2 SERPINC1
37 sporotrichosis 10.2 F2 F3
38 chronic inflammatory demyelinating polyneuritis 10.2 F2 F3
39 fletcher factor deficiency 10.1 F2 F3
40 craniodiaphyseal dysplasia 10.1 F3 PLG
41 ophthalmia neonatorum 10.1 F2 SERPINC1
42 vaginal discharge 10.1 F2 SERPINC1
43 arcus senilis 10.1 F3 PLG
44 alpha-2-plasmin inhibitor deficiency 10.1 F2 SERPINC1
45 spinocerebellar ataxia 27 10.1 F2 F3
46 retinal arterial macroaneurysm with supravalvular pulmonic stenosis 10.1 F2 F3
47 hereditary endotheliopathy, retinopathy, nephropathy, and stroke 10.1 F10 F3 SERPINC1
48 coccidioidomycosis 10.1 F2 PLG
49 invasive pneumococcal disease, recurrent isolated, 1 10.1 F10 F2
50 artery disease 10.1 F2 F3

Graphical network of the top 20 diseases related to Leech Infestation:



Diseases related to Leech Infestation

Symptoms & Phenotypes for Leech Infestation

MGI Mouse Phenotypes related to Leech Infestation:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.91 F10 F2 F3 FLNA JAK1 PLG
2 hematopoietic system MP:0005397 9.8 F2 F3 FLNA JAK1 PLG SERPINC1
3 homeostasis/metabolism MP:0005376 9.8 F10 F2 F3 FLNA JAK1 PLG
4 immune system MP:0005387 9.63 JAK1 PLG SERPINC1 F2 F3 FLNA
5 mortality/aging MP:0010768 9.5 F10 F2 F3 FLNA JAK1 PLG
6 respiratory system MP:0005388 9.02 F2 F3 FLNA JAK1 PLG

Drugs & Therapeutics for Leech Infestation

Drugs for Leech Infestation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 63)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aztreonam Approved Phase 3 78110-38-0 5362041 5742832
2
Sodium oxybate Approved Phase 3 502-85-2 5360545
3 Vaccines Phase 3,Phase 1,Phase 2
4 Pharmaceutical Solutions Phase 3,Phase 2
5 Anti-Bacterial Agents Phase 3
6 Antibiotics, Antitubercular Phase 3
7 Adjuvants, Anesthesia Phase 3
8 Anesthetics Phase 3
9 Anesthetics, General Phase 3
10 Anesthetics, Intravenous Phase 3
11 Central Nervous System Depressants Phase 3
12
Formaldehyde Approved, Vet_approved Phase 1, Phase 2 50-00-0 712
13 Disinfectants Phase 1, Phase 2
14 Anti-Infective Agents Phase 1, Phase 2
15 Aluminum sulfate Phase 1
16 Protein C Phase 1
17
Cyclosporine Approved, Investigational, Vet_approved 79217-60-0, 59865-13-3 5284373 6435893
18
Tacrolimus Approved, Investigational 104987-11-3 445643 439492
19
Aspirin Approved, Vet_approved Early Phase 1 50-78-2 2244
20
Cyclophosphamide Approved, Investigational 50-18-0, 6055-19-2 2907
21
Ramipril Approved Early Phase 1 87333-19-5 5362129
22
Metoprolol Approved, Investigational Early Phase 1 37350-58-6, 51384-51-1 4171
23
Norepinephrine Approved 51-41-2 439260
24
Diclofenac Approved, Vet_approved 15307-86-5 3033
25 Atorvastatin Calcium Early Phase 1 134523-03-8
26 Alkylating Agents
27 glucocorticoids
28
protease inhibitors Early Phase 1
29 Adrenergic Agents Early Phase 1
30 Adrenergic Antagonists Early Phase 1
31 Adrenergic beta-1 Receptor Antagonists Early Phase 1
32 Neurotransmitter Agents Early Phase 1
33 Adrenergic beta-Antagonists Early Phase 1
34 Sympatholytics Early Phase 1
35 HIV Protease Inhibitors Early Phase 1
36 Hormone Antagonists
37 Hormones
38 Peripheral Nervous System Agents Early Phase 1
39 Hormones, Hormone Substitutes, and Hormone Antagonists
40 Angiotensin-Converting Enzyme Inhibitors Early Phase 1
41 Hydroxymethylglutaryl-CoA Reductase Inhibitors Early Phase 1
42 Anti-Arrhythmia Agents Early Phase 1
43 Hypolipidemic Agents Early Phase 1
44 Immunosuppressive Agents
45 Anticholesteremic Agents Early Phase 1
46 Antihypertensive Agents Early Phase 1
47 Lipid Regulating Agents Early Phase 1
48 Antimetabolites Early Phase 1
49 Antirheumatic Agents
50 Antineoplastic Agents, Alkylating

Interventional clinical trials:

(show all 20)
id Name Status NCT ID Phase
1 Role of Sleep Apnea and Sympathetic Activity in Resistant Hypertensive Patients. Completed NCT01875341 Phase 3
2 Adult Safety Study of 2009/2010 Seasonal Influenza Vaccine Completed NCT01063088 Phase 3
3 Safety and Effectiveness of AZLI (an Inhaled Antibiotic) in Adults With Non-Cystic Fibrosis Bronchiectasis Completed NCT01314716 Phase 3
4 Extension of Study TKT024 Evaluating Long-Term Safety and Clinical Outcomes in MPS II Patients Receiving Idursulfase Completed NCT00630747 Phase 2, Phase 3
5 Sodium Oxybate for Treatment of Excessive Daytime Sleepiness and Cataplexy in Narcolepsy Recruiting NCT02720744 Phase 3
6 Clinical Evaluation of Leech Therapy in the Treatment of Knee Osteoarthritis Completed NCT02612974 Phase 2
7 Leeches for the Treatment of Knee Osteoarthritis Completed NCT00435773 Phase 2
8 A/H1N1 Immunogenicity and Safety in Adults Completed NCT00959465 Phase 1, Phase 2
9 Open-label Study to Assess Immunogenicity and Safety of a Vaccine Enhancement Patch When Administered With 2 Doses of H5N1 Vaccine Completed NCT01353534 Phase 1, Phase 2
10 Safety and Immunogenicity Study of a Ross River Virus (RRV) Vaccine Completed NCT00717834 Phase 1, Phase 2
11 Safety and Pharmacokinetics of Single and Multiple Ascending Doses of 3K3A-APC in Healthy Adult Volunteers Completed NCT01660230 Phase 1
12 An Open-label Study Assessing Safety, Immunogenicity and Dose Response of IC84 Completed NCT01296386 Phase 1
13 Acupoint Application in Patients With Stable Angina Pectoris (AASAP) Unknown status NCT02029118 Early Phase 1
14 Study on Single-nucleotide-polymorphism in Idiopathic Membranous Nephropathy Unknown status NCT01799460
15 RISA Extension Study - Long Term Safety Unknown status NCT00401986
16 Effectiveness and Safety of Breeded Leech for Symptomatic Primary Arthrosis of the First Carpometacarpal Joint Recruiting NCT03020368
17 ASV Effects on Myocardial Energetics and Sympathetic Nerve Function in Heart Failure and Sleep Apnea. Recruiting NCT02116140
18 The National Myelodysplastic Syndromes (MDS) Study Recruiting NCT02775383
19 Pulmonary Embolism Short-term Clinical Outcomes Registry Recruiting NCT02883491
20 Leech Therapy for Postherpetic Neuralgia Terminated NCT01744522

Search NIH Clinical Center for Leech Infestation

Genetic Tests for Leech Infestation

Anatomical Context for Leech Infestation

MalaCards organs/tissues related to Leech Infestation:

39
Heart, Eye

Publications for Leech Infestation

Articles related to Leech Infestation:

(show all 44)
id Title Authors Year
1
Epistaxis Due to Leech Infestation in Nose: A Report of Six Cases and Review of Literature. ( 27066409 )
2016
2
Bronchial Leech Infestation in a 15-Year-Old Female. ( 27752380 )
2016
3
Upper airway obstruction and hemoptysis due to a leech infestation in a child. ( 26655785 )
2016
4
Vaginal Leech Infestation: A Rare Cause of Hypovolumic Shock In Postmenopausal Woman. ( 26949304 )
2015
5
An Unusual Cause of Bleeding on the Floor of Mouth: Leech Infestation. ( 26809923 )
2015
6
Ocular leech infestation. ( 25784786 )
2015
7
Mass leech infestation of sculpin fish in Lake Baikal, with clarification of disease-prone species and parasite taxonomy. ( 25004101 )
2014
8
Leech Infestation in the Vulvar Region: A Possibility to be Considered. ( 25709802 )
2014
9
A rare case report of tracheal leech infestation in a 40-year-old woman. ( 25419405 )
2014
10
Leech infestation: the unusual cause of upper airway obstruction. ( 23559840 )
2013
11
Ocular leech infestation initially misdiagnosed as conjunctival pigmented nevus. ( 23991397 )
2013
12
Eye bleeding due to leech infestation in an ischemic heart- disease patient. ( 22754689 )
2012
13
Leech infestation in children through body orifices: experience in a hospital in Bangladesh. ( 22543722 )
2012
14
Intermittent gastrointestinal bleeding in a child: leech infestation. ( 23429838 )
2012
15
Nasal leech infestation causing persistent epistaxis. ( 21887037 )
2011
16
Oropharyngeal leech infestation and therapeutic options. ( 21391194 )
2010
17
Ocular leech infestation. ( 20804315 )
2010
18
Nasal leech infestation: report of seven leeches and literature review. ( 20037786 )
2010
19
Nasal leech infestation in children: comparison of two different innovative techniques. ( 19395059 )
2009
20
An unusual cause of gastrointestinal bleeding and severe anemia in a child: leech infestation. ( 19264837 )
2009
21
A case series of bleeding due to Leech infestation from the Gimbie region, Ethiopia. ( 18302875 )
2008
22
Unusual cause of unilateral epistaxis: nasal leech infestation. ( 18552891 )
2008
23
Adult ocular leech infestation. ( 15832186 )
2006
24
A case of conjunctival leech infestation. ( 16453190 )
2006
25
Leech infestation and its association with water drinking habits. ( 16542595 )
2006
26
Aquatic leech infestation: a rare cause of severe anaemia in an adolescent Tanzanian girl. ( 15346909 )
2004
27
The influence of agricultural and urban contamination on leech infestation of freshwater turtles, Phrynops geoffroanus, taken from two areas of the Uberabinha River. ( 15327164 )
2004
28
Unexpected result in the etiological approaching to an anemic case: a leech infestation. ( 12959860 )
2003
29
Leech infestation: an unusual cause of hoarseness. ( 11991029 )
2002
30
Leech infestation as a potential cause of hemoptysis in childhood. ( 11784268 )
2002
31
Ocular leech infestation in a child. ( 9222244 )
1997
32
Post menopausal vaginal bleeding due to vaginal wall leech infestation. ( 8674494 )
1995
33
Post menopausal vaginal bleeding due to vaginal wall leech infestation. ( 7588657 )
1995
34
Haematemesis due to leech infestation. ( 1694646 )
1990
35
Leech infestation of mute swans (Cygnus olor) ( 2718339 )
1989
36
Leech infestation of livestock. ( 2773211 )
1989
37
Tails of the unexpectorated: experiences with leech infestation in childhood. ( 2449848 )
1987
38
Nasal leech infestation of man. ( 3603699 )
1987
39
Leech infestation of man in Al-Taif, Saudi Arabia. ( 3693958 )
1987
40
Correlation of leech infestation and eosinophilia in alligators. ( 448620 )
1979
41
Leech infestation of man in Rhodesia. ( 860320 )
1977
42
Nasal leech infestation in the rhesus monkey. ( 4249653 )
1970
43
Nasal leech infestation in man. ( 5493048 )
1970
44
Further note on leech infestation in man. ( 18119173 )
1949

Variations for Leech Infestation

Expression for Leech Infestation

Search GEO for disease gene expression data for Leech Infestation.

Pathways for Leech Infestation

Pathways related to Leech Infestation according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.78 F10 F2 F3 FLNA JAK1 PLG
2
Show member pathways
12.34 F10 F2 F3 SERPINC1
3
Show member pathways
12.14 F2 JAK1 PLG
4
Show member pathways
11.56 F10 F2 F3 PLG SERPINC1
5 11.16 F10 F2 F3 PLG SERPINC1
6 10.9 F2 PLG
7 10.69 F2 PLG
8 10.43 F10 F2

GO Terms for Leech Infestation

Cellular components related to Leech Infestation according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.43 F10 F2 SERPINC1
2 extracellular region GO:0005576 9.43 F10 F2 F3 FLNA PLG SERPINC1
3 blood microparticle GO:0072562 9.33 F2 PLG SERPINC1
4 intrinsic component of external side of plasma membrane GO:0031233 8.62 F10 F3

Biological processes related to Leech Infestation according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.65 F2 PLG SERPINC1
2 regulation of blood coagulation GO:0030193 9.46 F2 SERPINC1
3 fibrinolysis GO:0042730 9.43 F2 PLG
4 signal peptide processing GO:0006465 9.4 F10 F2
5 blood coagulation, intrinsic pathway GO:0007597 9.37 F10 F2
6 blood coagulation GO:0007596 9.35 F10 F2 F3 PLG SERPINC1
7 peptidyl-glutamic acid carboxylation GO:0017187 9.32 F10 F2
8 negative regulation of fibrinolysis GO:0051918 9.26 F2 PLG
9 blood coagulation, extrinsic pathway GO:0007598 9.16 F10 F3
10 hemostasis GO:0007599 9.02 F10 F2 F3 PLG SERPINC1

Molecular functions related to Leech Infestation according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 serine-type peptidase activity GO:0008236 9.13 F10 F2 PLG
2 serine-type endopeptidase activity GO:0004252 8.92 F10 F2 F3 PLG

Sources for Leech Infestation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....