MCID: LFT009
MIFTS: 55

Left Ventricular Outflow Tract Obstruction malady

Genetic diseases (common), Cardiovascular diseases categories

Summaries for Left Ventricular Outflow Tract Obstruction

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MalaCards: Left Ventricular Outflow Tract Obstruction, also known as hypoplastic left heart syndrome, is related to hypertensive heart disease and hypertension. An important gene associated with Left Ventricular Outflow Tract Obstruction is NOTCH1 (notch 1), and among its related pathways are Heart Development and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The drug alprostadil and the compounds temocaprilat and aliskiren have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and lung, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Aliases & Classifications for Left Ventricular Outflow Tract Obstruction

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63UMLS, 21GeneTests, 23GTR, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

left ventricular outflow tract obstruction 21 23
hypoplastic left heart syndrome 63
aortic valve stenosis 63
aortic valve disorder 63


External Ids:

ICD1026 I39.1

Related Diseases for Left Ventricular Outflow Tract Obstruction

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18GeneCards, 19GeneDecks
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Diseases related to Left Ventricular Outflow Tract Obstruction via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 79)
idRelated DiseaseScoreTop Affiliating Genes
1hypertensive heart disease30.9ACE, AGTR1
2hypertension30.8AGTR1, ACE, NOTCH1
3adenocarcinoma30.4VEGFA, NOTCH1, EGFR, AGTR1, ERBB4
4hypertrophic cardiomyopathy11.2
5transposition of the great arteries11.1
6ventricular septal defect11.1
7myocardial infarction11.0
8accessory mitral valve tissue10.9
9cardiogenic shock10.8
10acute myocardial infarction10.8
11atrioventricular septal defect10.7
12double outlet right ventricle10.7
13syncope10.7
14ischemia10.6
15aneurysm10.6
16atrioventricular block10.5
17mitral valve prolapse10.5
18amyloidosis10.5
19pheochromocytoma10.5
20mitral valve stenosis10.4
21hypoplastic left heart syndrome10.4
22diastolic heart failure10.4
23cerebritis10.4
24inferior myocardial infarction10.4
25tricuspid valve prolapse10.4
26fabry disease10.4
27aortic valve stenosis10.4
28hemiplegia10.4
29hemolytic anemia10.4
30liposarcoma10.4
31lung adenocarcinoma10.4
32pericardial effusion10.4
33renal cell carcinoma10.4
34subvalvular aortic stenosis10.4
35pulmonary atresia with intact ventricular septum10.4
36stress cardiomyopathy10.4
37thromboembolism10.4
38tunnel subaortic stenosis10.4
39renal tubular dysgenesis10.1AGTR1, ACE
40nephrosclerosis10.1ACE, AGTR1
41renovascular hypertension10.1ACE, AGTR1
42hyperaldosteronism10.1AGTR1, ACE
43erythrocytosis10.1AGTR1, ACE
44focal segmental glomerulosclerosis10.1ACE, AGTR1
45cerebrovascular disease10.1ACE, AGTR1
46glomerulosclerosis10.0AGTR1, ACE
47iga glomerulonephritis10.0ACE, AGTR1
48cork-handlers' disease10.0ACE, EGFR
49congestive heart failure10.0AGTR1, ACE
50familial hyperlipidemia10.0ACE, AGTR1

Graphical network of the top 20 diseases related to Left Ventricular Outflow Tract Obstruction:



Diseases related to left ventricular outflow tract obstruction

Symptoms for Left Ventricular Outflow Tract Obstruction

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Drugs & Therapeutics for Left Ventricular Outflow Tract Obstruction

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Left Ventricular Outflow Tract Obstruction

Drug clinical trials:

Search ClinicalTrials for Left Ventricular Outflow Tract Obstruction

Search NIH Clinical Center for Left Ventricular Outflow Tract Obstruction

Search CenterWatch for Left Ventricular Outflow Tract Obstruction

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Left Ventricular Outflow Tract Obstruction

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21GeneTests, 23GTR
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Genetic tests related to Left Ventricular Outflow Tract Obstruction:

id Genetic test Affiliating Genes
1 Left Ventricular Outflow Tract Obstruction (lvoto)21 23 NOTCH1

Anatomical Context for Left Ventricular Outflow Tract Obstruction

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34MalaCards
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MalaCards organs/tissues related to Left Ventricular Outflow Tract Obstruction:

34
Heart, Liver, Lung, Testes

Animal Models for Left Ventricular Outflow Tract Obstruction or affiliated genes

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38MGI
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Publications for Left Ventricular Outflow Tract Obstruction

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53PubMed
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Articles related to Left Ventricular Outflow Tract Obstruction:

(show top 50)    (show all 391)
idTitleAuthorsYear
1
Relation between left ventricular outflow tract obstruction and left ventricular shape in patients with hypertrophic cardiomyopathy: a cardiac magnetic resonance imaging study. (23906680)
2013
2
Predictors of long-term outcomes in symptomatic hypertrophic obstructive cardiomyopathy patients undergoing surgical relief of left ventricular outflow tract obstruction. (23770748)
2013
3
Left ventricular outflow tract obstruction following an uncomplicated primary percutaneous coronary intervention: a recognized but rare cause of cardiogenic shock. (24062935)
2013
4
The role of alcohol septal ablation in the treatment of left ventricular outflow tract obstruction in hypertrophic cardiomyopathy. (22093511)
2011
5
Exercise-induced left ventricular outflow tract obstruction in symptomatic patients with Anderson-Fabry disease. (21700093)
2011
6
Cardiogenic shock due to dynamic left ventricular outflow tract obstruction in acute myocardial infarction. (21452037)
2011
7
Modified Nikaidoh procedure in a patient with transposition of the great arteries, ventricular septal defect, and left ventricular outflow tract obstruction with unusual coronary anatomy. (21729497)
2011
8
Haemodynamic effects of acute intravenous metoprolol in apical ballooning syndrome with dynamic left ventricular outflow tract obstruction. (20097684)
2010
9
Surgical management of left ventricular outflow tract obstruction after biventricular repair of double outlet right ventricle. (20191035)
2010
10
Left ventricular outflow tract obstruction after the modified single patch repair of atrioventricular septal defects: teasing fact from fiction. (20338382)
2010
11
Mutations in VEGFA are associated with congenital left ventricular outflow tract obstruction. (20420808)
2010
12
The optimal procedure for the great arteries and left ventricular outflow tract obstruction. An anatomical study. (17353131)
2007
13
Left ventricular rhabdomyoma with severe left ventricular outflow tract obstruction: development of delayed hemiplegia after cardiopulmonary bypass. (17803580)
2007
14
Takotsubo cardiomyopathy with left ventricular outflow tract obstruction. (16337511)
2006
15
Different effects of propranolol, phenylephrine, and saline volume loading on catecholamine-induced left ventricular outflow tract obstruction in acute coronary syndrome. (16607055)
2006
16
Left ventricular outflow tract obstruction and sudden death risk in patients with hypertrophic cardiomyopathy. (16754630)
2006
17
Systolic anterior motion (SAM) of the posterior mitral leaflet: left ventricular outflow tract obstruction in a patient without left ventricular hypertrophy. (15939492)
2006
18
Long-term results of apical aortic conduits in children with complex left ventricular outflow tract obstruction. (16305893)
2005
19
Multiple causes of left ventricular outflow tract obstruction in a 58-year-old woman. (15901301)
2005
20
Catecholamine therapy inducing dynamic left ventricular outflow tract obstruction. (15882688)
2005
21
Repair of transposition of the great arteries, ventricular septal defect and left ventricular outflow tract obstruction. (15082275)
2004
22
Patients with mild hypertensive heart disease and left ventricular outflow tract obstruction: treatment with angiotensin II antagonists. (15372301)
2004
23
Inferior myocardial infarction and shock associated with left ventricular outflow tract obstruction. (15322669)
2004
24
Effect of left ventricular outflow tract obstruction on clinical outcome in hypertrophic cardiomyopathy. (12540642)
2003
25
Echocardiographic diagnosis of left ventricular outflow tract obstruction after mitral valve replacement with subvalvular preservation. (12414054)
2002
26
Hypovolemia-induced reversible severe mitral regurgitation due to left ventricular outflow tract obstruction. (12487637)
2002
27
Comparison of left ventricular outflow tract obstruction in interruption of the aortic arch and in coarctation of the aorta, with diagnostic, developmental, and surgical implications. (11024401)
2000
28
Critical left ventricular outflow tract obstruction due to accessory mitral valve tissue. (10978978)
2000
29
Potential mechanism of left ventricular outflow tract obstruction after mitral ring annuloplasty. (10047649)
1999
30
Echocardiographic predictors of left ventricular outflow tract obstruction and systolic anterior motion of the mitral valve after mitral valve reconstruction for myxomatous valve disease. (10588230)
1999
31
Dynamic left ventricular outflow tract obstruction as a potential mechanism of myocardial rupture after acute myocardial infarction. (10588241)
1999
32
Echocardiographic diagnosis of left ventricular outflow tract obstruction caused by an acquired subaortic membrane after mitral valve replacement. (10231618)
1999
33
Dynamic left ventricular outflow tract obstruction in a patient with pheochromocytoma. (10737567)
1999
34
Patch repair of subsemilunar conal septal defect resulting in severe left ventricular outflow tract obstruction. (9359571)
1997
35
Left ventricular outflow tract obstruction as a cause for hypotension and symptoms during dobutamine stress echocardiography. (8674261)
1996
36
Repair of complex left ventricular outflow tract obstruction with a pulmonary autograft. (7582142)
1995
37
Relief of complex left ventricular outflow tract obstruction with pulmonary autografts. (7739236)
1995
38
Reduction of the left-ventricular outflow-tract obstruction by aortoventriculoplasty--long-term results of 96 patients. (8211925)
1993
39
Increased left ventricular outflow tract obstruction during exercise in patients with hypertrophic cardiomyopathy. (8426026)
1993
40
Left ventricular outflow tract obstruction with aortic arch anomalies and ventricular septal defect. (2241361)
1990
41
Accessory mitral valve leaflet causing aortic regurgitation and left ventricular outflow tract obstruction. Case report and review of published reports. (3285879)
1988
42
Noninvasive diagnosis of left ventricular outflow tract obstruction caused by a porcine mitral prosthesis. (3819212)
1987
43
Double outlet right ventricle with severe left ventricular outflow tract obstruction due to small ventricular septal defect and anomalous adherence of the mitral valve to the ventricular septum. (3437510)
1987
44
Left ventricular outflow tract obstruction with mitral valve replacement in small ventricular cavities. (3942435)
1986
45
Dynamic left ventricular outflow tract obstruction associated with pheochromocytoma. (7196146)
1981
46
The spectrum of left ventricular outflow tract obstruction: an overview. (7006467)
1980
47
Aortoventriculoplasty: a new technique for the treatment of left ventricular outflow tract obstruction. (131885)
1976
48
Parachute accessory anterior mitral valve leaflet causing left ventricular outflow tract obstruction. Report of a case with emphasis on the echocardiographic findings. (944108)
1976
49
Left ventricular outflow-tract obstruction with an ostium primum defect. Report of two cases. (5437896)
1970
50
Roentgenographic aspects of congenital left ventricular outflow tract obstruction. (5844924)
1965

Variations for Left Ventricular Outflow Tract Obstruction

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1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Left Ventricular Outflow Tract Obstruction:

1
id Gene Name Type Significance SNP ID Assembly Location
1GJA1NM_000165.3(GJA1): c.1085G> A (p.Arg362Gln)single nucleotide variantPathogenicrs2227885GRCh37Chr 6, 121769078: 121769078
2GJA1NM_000165.3(GJA1): c.1127G> A (p.Arg376Gln)single nucleotide variantPathogenicrs104893965GRCh37Chr 6, 121769120: 121769120

Expression for genes affiliated with Left Ventricular Outflow Tract Obstruction

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Left Ventricular Outflow Tract Obstruction

Search GEO for disease gene expression data for Left Ventricular Outflow Tract Obstruction.

Pathways for genes affiliated with Left Ventricular Outflow Tract Obstruction

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51PathCards, 39NCBI BioSystems Database, 52PharmGKB, 31KEGG, 56Reactome, 54QIAGEN, 62Tocris Bioscience, 61Thomson Reuters, 13EMD Millipore, 55R&D Systems, 58SinoBiological
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Pathways related to Left Ventricular Outflow Tract Obstruction according to GeneCards/GeneDecks:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5NOTCH1, VEGFA
2
Show member pathways
9.5AGTR1, ACE
39.4EGFR, NOTCH1
4
Show member pathways
Delta-Notch Signaling Pathway39
Notch Signaling Pathway39
9.4EGFR, NOTCH1
59.4AGTR1, EGFR
69.3VEGFA, EGFR
7
Show member pathways
9.3VEGFA, EGFR
89.3VEGFA, EGFR
9
Show member pathways
Development Ligand dependent activation of the ESR1 AP 1 pathway61
9.3VEGFA, EGFR
10
Show member pathways
9.3EGFR, VEGFA
11
Show member pathways
9.0EGFR, ERBB4
12
Show member pathways
9.0EGFR, ERBB4
139.0EGFR, ERBB4
14
Show member pathways
ErbB receptor signaling network39
ErbB signaling pathway39
9.0EGFR, ERBB4
15
Show member pathways
9.0EGFR, ERBB4
169.0EGFR, ERBB4
179.0EGFR, ERBB4
189.0EGFR, ERBB4
198.9VEGFA, NOTCH1, EGFR
20
Show member pathways
8.9AGTR1, EGFR, ACE
21
Show member pathways
8.6ERBB4, NOTCH1, EGFR
22
Show member pathways
8.6ERBB4, EGFR, AGTR1
238.6AGTR1, EGFR, ERBB4
24
Show member pathways
8.5EGFR, ERBB4, VEGFA
258.5VEGFA, ERBB4, EGFR
26
Show member pathways
7.6AGTR1, EGFR, NOTCH1, ERBB4, VEGFA

Compounds for genes affiliated with Left Ventricular Outflow Tract Obstruction

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46Novoseek, 12DrugBank, 30IUPHAR, 25HMDB, 62Tocris Bioscience, 52PharmGKB, 3BitterDB
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Compounds related to Left Ventricular Outflow Tract Obstruction according to GeneCards/GeneDecks:

(show top 50)    (show all 111)
idCompoundScoreTop Affiliating Genes
1temocaprilat469.9AGTR1, ACE
2aliskiren46 1210.9AGTR1, ACE
3lacidipine469.8ACE, AGTR1
4angiotensin ii30 2510.8ACE, AGTR1
5saralasin469.8AGTR1, ACE
6eprosartan46 30 1211.8ACE, AGTR1
7cilazapril46 1210.8ACE, AGTR1
8pd12331946 3010.8AGTR1, ACE
9trandolapril46 1210.8AGTR1, ACE
10bradykinin62 30 2511.8AGTR1, ACE
11olmesartan46 30 1211.7AGTR1, ACE
12fosinopril46 1210.7ACE, AGTR1
13eplerenone46 62 30 1212.7AGTR1, ACE
14panitumumab46 52 1211.7VEGFA, EGFR
15ptk787469.7EGFR, VEGFA
16benazepril46 52 1211.6AGTR1, ACE
17zd6474469.6EGFR, VEGFA
18quinapril46 52 1211.5AGTR1, ACE
19hb-egf309.5EGFR, ERBB4
20epiregulin309.4ERBB4, EGFR
21betacellulin309.4ERBB4, EGFR
22vandetanib52 1210.4VEGFA, EGFR
23pd158780469.4EGFR, ERBB4
24lisinopril46 52 25 1212.4AGTR1, VEGFA, ACE
25ag 1478 hydrochloride629.4ERBB4, EGFR
26jnj 28871063 hydrochloride629.4EGFR, ERBB4
27perindopril46 52 1211.4AGTR1, ACE, VEGFA
28candesartan46 52 30 1212.4AGTR1, VEGFA, ACE
29ag 490629.4ERBB4, EGFR
30carvedilol46 52 30 1212.4VEGFA, AGTR1, ACE
31iressa629.4EGFR, ERBB4
32aldosterone30 25 1211.4AGTR1, EGFR
33pertuzumab46 52 1211.4EGFR, ERBB4
34hrgbeta1469.4ERBB4, EGFR
35suramin46 30 1211.2AGTR1, EGFR, VEGFA
36su5416469.2EGFR, VEGFA
37prostacyclin469.2VEGFA, ACE, AGTR1
38capecitabine46 52 1211.0VEGFA, EGFR
39pd153035469.0ERBB4, VEGFA, EGFR
40cetuximab46 52 1210.9ERBB4, VEGFA, EGFR
41trastuzumab46 52 1210.9EGFR, ERBB4, VEGFA
42gefitinib46 52 1210.9VEGFA, ERBB4, EGFR
43ang ii468.8EGFR, AGTR1, ACE, VEGFA
44tamoxifen46 52 30 1211.5EGFR, ERBB4, VEGFA, AGTR1
45cisplatin46 52 62 1211.5ERBB4, EGFR, AGTR1, VEGFA
46phosphatidylinositol468.2NOTCH1, AGTR1, EGFR, ERBB4
47genistein46 30 62 3 25 1213.1VEGFA, AGTR1, EGFR, NOTCH1, ERBB4
48vegf468.1AGTR1, NOTCH1, VEGFA, EGFR, ERBB4
49estrogen468.1NOTCH1, AGTR1, EGFR, ERBB4, VEGFA
50tyrosine467.9AGTR1, ERBB4, EGFR, NOTCH1, VEGFA

GO Terms for genes affiliated with Left Ventricular Outflow Tract Obstruction

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17Gene Ontology
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Cellular components related to Left Ventricular Outflow Tract Obstruction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099868.9EGFR, NOTCH1, VEGFA
2receptor complexGO:0432358.7EGFR, NOTCH1, ERBB4
3extracellular regionGO:0055768.1VEGFA, ACE, ERBB4, NOTCH1
4integral component of membraneGO:0160217.6AGTR1, EGFR, NOTCH1, ERBB4, ACE
5plasma membraneGO:0058867.3ACE, ERBB4, NOTCH1, EGFR, AGTR1

Biological processes related to Left Ventricular Outflow Tract Obstruction according to GeneCards/GeneDecks:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1coronary vein morphogenesisGO:0031699.9NOTCH1, VEGFA
2positive regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:0614199.9VEGFA, NOTCH1
3cardiac vascular smooth muscle cell developmentGO:0609489.9VEGFA, NOTCH1
4coronary artery morphogenesisGO:0609829.9VEGFA, NOTCH1
5tube formationGO:0351489.8NOTCH1, VEGFA
6regulation of systemic arterial blood pressure by renin-angiotensinGO:0030819.8AGTR1, ACE
7regulation of vasodilationGO:0423129.8AGTR1, ACE
8cellular response to vascular endothelial growth factor stimulusGO:0359249.8VEGFA, NOTCH1
9regulation of vasoconstrictionGO:0192299.8AGTR1, ACE
10branching morphogenesis of an epithelial tubeGO:0487549.7NOTCH1, VEGFA
11positive regulation of inflammatory responseGO:0507299.5AGTR1, EGFR
12positive regulation of cardiac muscle cell proliferationGO:0600459.5ERBB4, NOTCH1
13positive regulation of MAP kinase activityGO:0434069.5VEGFA, EGFR
14liver developmentGO:0018899.4NOTCH1, EGFR
15mammary gland alveolus developmentGO:0607499.4ERBB4, VEGFA
16lactationGO:0075959.3ERBB4, VEGFA
17kidney developmentGO:0018229.3VEGFA, ACE, AGTR1
18positive regulation of epithelial cell proliferationGO:0506799.3EGFR, NOTCH1, VEGFA
19lung developmentGO:0303249.3EGFR, NOTCH1, VEGFA
20positive regulation of cell migrationGO:0303359.2VEGFA, NOTCH1, EGFR
21peptidyl-tyrosine phosphorylationGO:0181088.9EGFR, ERBB4
22positive regulation of transcription from RNA polymerase II promoterGO:0459448.9EGFR, NOTCH1, VEGFA
23positive regulation of protein phosphorylationGO:0019348.8EGFR, ERBB4, VEGFA
24positive regulation of ERK1 and ERK2 cascadeGO:0703748.7EGFR, ERBB4
25negative regulation of apoptotic processGO:0430668.6EGFR, ERBB4, VEGFA
26positive regulation of cell proliferationGO:0082848.4VEGFA, ERBB4, NOTCH1, EGFR

Molecular functions related to Left Ventricular Outflow Tract Obstruction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1bradykinin receptor bindingGO:0317119.6AGTR1, ACE
2receptor signaling protein tyrosine kinase activityGO:0047169.1EGFR, ERBB4
3protein tyrosine kinase activityGO:0047139.0EGFR, ERBB4
4transmembrane receptor protein tyrosine kinase activityGO:0047148.9EGFR, ERBB4
5protein heterodimerization activityGO:0469828.6VEGFA, EGFR, AGTR1
6protein bindingGO:0055157.1VEGFA, ACE, ERBB4, NOTCH1, EGFR, AGTR1

Products for genes affiliated with Left Ventricular Outflow Tract Obstruction

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Sources for Left Ventricular Outflow Tract Obstruction

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet