MCID: LFT009
MIFTS: 52

Left Ventricular Outflow Tract Obstruction malady

Cardiovascular category

Summaries for Left Ventricular Outflow Tract Obstruction

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33MalaCards
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MalaCards: Left Ventricular Outflow Tract Obstruction, also known as hypoplastic left heart syndrome, is related to acute myocardial infarction and mitral valve prolapse. An important gene associated with Left Ventricular Outflow Tract Obstruction is NOTCH1 (notch 1), and among its related pathways are Heart Development and Dorso-ventral axis formation. The drug alprostadil and the compounds temocaprilat and aliskiren have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and lung, and related mouse phenotypes are endocrine/exocrine gland and tumorigenesis.

Aliases & Classifications for Left Ventricular Outflow Tract Obstruction

Sources:
20GeneTests, 22GTR, 61UMLS, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular


Aliases & Descriptions:

left ventricular outflow tract obstruction 20 22
hypoplastic left heart syndrome 61
aortic valve disorder 61
aortic valve stenosis 61


External Ids:

ICD1025 I39.1

Related Diseases for Left Ventricular Outflow Tract Obstruction

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17GeneCards, 18GeneDecks
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Diseases related to Left Ventricular Outflow Tract Obstruction via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 202)
idRelated DiseaseScoreTop Affiliating Genes
1acute myocardial infarction31.3ACE, AGTR1
2mitral valve prolapse30.8AGTR1
3hypertensive heart disease30.8AGTR1, ACE
4adenocarcinoma30.5EGFR, AGTR1, VEGFA, NOTCH1, ERBB4
5arthritis30.4AGTR1
6coronary heart disease30.4ACE, AGTR1
7hypercholesterolemia30.2ACE, AGTR1
8hypertrophic cardiomyopathy11.2
9ventricular septal defect11.1
10accessory mitral valve tissue10.9
11aortic valve disease10.8
12cardiogenic shock10.8
13aortic disease10.8
14atrioventricular septal defect10.8
15arc syndrome10.8
16double outlet left ventricle10.7
17syncope10.7
18coronary artery disease,10.6
19conn's syndrome10.6
20tau syndrome10.6
21atrioventricular block10.6
22stress cardiomyopathy10.6
23aortic coarctation10.6
24carotid stenosis10.6
25rheumatic aortic valve stenosis10.5
26aortic aneurysm10.5
27amyloidosis10.5
28aortic valve stenosis10.5
29pheochromocytoma10.5
30tako-tsubo cardiomyopathy10.5
31tricuspid valve stenosis10.5
32mitral atresia10.5
33angiodysplasia10.4
34endocardial fibroelastosis10.4
35kabuki syndrome10.4
36image syndrome10.4
37alkaptonuria10.4
38ochronosis10.4
39aortic atherosclerosis10.4
40atherosclerosis10.4
41cardiac rupture10.4
42congenital pulmonary valve stenosis10.4
43aortic valve atresia10.4
44ebstein anomaly10.4
45mitral valve stenosis10.4
46tricuspid valve prolapse10.4
47hypoplastic left heart syndrome10.4
48diastolic heart failure10.4
49inferior myocardial infarction10.4
50fabry disease10.4

Graphical network of the top 20 diseases related to Left Ventricular Outflow Tract Obstruction:



Diseases related to left ventricular outflow tract obstruction

Clinical Features for Left Ventricular Outflow Tract Obstruction

Drugs & Therapeutics for Left Ventricular Outflow Tract Obstruction

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Left Ventricular Outflow Tract Obstruction

Drug clinical trials:

Search ClinicalTrials for Left Ventricular Outflow Tract Obstruction

Search NIH Clinical Center for Left Ventricular Outflow Tract Obstruction

Search CenterWatch for Left Ventricular Outflow Tract Obstruction

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Left Ventricular Outflow Tract Obstruction

Sources:
20GeneTests, 22GTR
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Genetic tests related to Left Ventricular Outflow Tract Obstruction:

id Genetic test Affiliating Genes
1 Left Ventricular Outflow Tract Obstruction (lvoto)20 22 NOTCH1

Anatomical Context for Left Ventricular Outflow Tract Obstruction

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33MalaCards
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MalaCards organs/tissues related to Left Ventricular Outflow Tract Obstruction:

33
Heart, Liver, Lung, Fetal liver, Fetal lung

Animal Models for Left Ventricular Outflow Tract Obstruction or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Left Ventricular Outflow Tract Obstruction

Sources:
51PubMed
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Articles related to Left Ventricular Outflow Tract Obstruction:

(show top 50)    (show all 400)
idTitleAuthorsYear
1
Relation between left ventricular outflow tract obstruction and left ventricular shape in patients with hypertrophic cardiomyopathy: a cardiac magnetic resonance imaging study. (23906680)
2013
2
A very unusual cause of mechanical left ventricular outflow tract obstruction. (23533200)
2013
3
Dynamic left ventricular outflow tract obstruction: hemodynamic pitfall ahead. (23927419)
2013
4
The diagnosis of left ventricular outflow tract obstruction in hypertrophic cardiomyopathy. (22948303)
2012
5
Basic echocardiographic features of patients with latent left ventricular outflow tract obstruction without left ventricular hypertrophy. (22878800)
2012
6
Modified Nikaidoh operation in a patient with dextro-transposition of the great arteries, ventricular septal defect, and left ventricular outflow tract obstruction. (23262041)
2012
7
Improving left ventricular outflow tract obstruction repair in common atrioventricular canal defects. (22626757)
2012
8
Left ventricular outflow tract obstruction after bioprosthetic mitral valve replacement with preservation of the anterior leaflet. (21546891)
2011
9
Double-trouble Doppler: reduction in aortic flow due to combined left ventricular outflow tract obstruction and severe aortic stenosis, complete diagnosis by transthoracic Doppler echocardiography. (20810244)
2011
10
Isolated dynamic left ventricular outflow tract obstruction can cause hypotension that rapidly responds to intravenous beta blockade. (20592665)
2011
11
Images in cardiovascular medicine. Left ventricular outflow tract obstruction caused by tamponade. (21859977)
2011
12
Virtual cardioscopy-guided surgical resection for left ventricular outflow tract obstruction. (21996402)
2011
13
Surgical management of left ventricular outflow tract obstruction after biventricular repair of double outlet right ventricle. (20191035)
2010
14
Left ventricular outflow tract obstruction after the modified single patch repair of atrioventricular septal defects: teasing fact from fiction. (20338382)
2010
15
Malpositioned mechanical mitral valves causing left ventricular outflow tract obstruction. (20369509)
2010
16
Comparison of Valsalva manoeuvre and exercise in echocardiographic evaluation of left ventricular outflow tract obstruction in hypertrophic cardiomyopathy. (20472917)
2010
17
Abnormally thickened papillary muscle resulting in dynamic left ventricular outflow tract obstruction: an unusual presentation of hypertrophic cardiomyopathy. (19131012)
2009
18
Unexplained hypotension: the spectrum of dynamic left ventricular outflow tract obstruction in critical care settings. (19114882)
2009
19
Accessory mitral valve causing left ventricular outflow tract obstruction in an adult. (18297463)
2008
20
Prevalence of exercise-induced left ventricular outflow tract obstruction in symptomatic patients with non-obstructive hypertrophic cardiomyopathy. (18032461)
2008
21
Left ventricular outflow tract obstruction after mitral valve replacement. (18165554)
2008
22
Left ventricular rhabdomyoma with severe left ventricular outflow tract obstruction: development of delayed hemiplegia after cardiopulmonary bypass. (17803580)
2007
23
Cardiac metastasis from lung adenocarcinoma causing atrioventricular block and left ventricular outflow tract obstruction. (17494807)
2007
24
Aortic root translocation plus arterial switch for transposition of the great arteries with left ventricular outflow tract obstruction: intermediate-term results. (17258095)
2007
25
Selective management of the left ventricular outflow tract for repair of interrupted aortic arch with ventricular septal defect: management of left ventricular outflow tract obstruction. (16580434)
2006
26
Autosomal dominant inheritance of left ventricular outflow tract obstruction. (15712195)
2005
27
Accessory mitral valve tissue causing severe left ventricular outflow tract obstruction in an adult. (14759472)
2004
28
The modified Konno procedure for complex left ventricular outflow tract obstruction. (12537208)
2003
29
Left ventricular outflow tract obstruction: the role of the modified Konno procedure. (12740776)
2003
30
Dobutamine induced dynamic left ventricular outflow tract obstruction in patients with hypertrophic nonobstructive cardiomyopathy. (12512992)
2002
31
Accessory mitral valve tissue as a cause of left ventricular outflow tract obstruction and probable cause of cerebrovascular accident. (12542122)
2002
32
An intraoperative diagnosis of dynamic left ventricular outflow tract obstruction using transesophageal echocardiography leads to the treatment with intravenous disopyramide. (11812689)
2002
33
Anteroapical stunning and left ventricular outflow tract obstruction. (11155418)
2001
34
Dynamic left ventricular outflow tract obstruction complicating acute myocardial infarction. (11567603)
2001
35
Modified Rastelli using an autograft: A new concept for correction of transposition of the great arteries with ventricular septal defect and left ventricular outflow tract obstruction (with an extension to other congenital heart defects). (11486190)
2000
36
Dynamic left ventricular outflow tract obstruction in acute coronary syndromes. (10683665)
2000
37
Asymptomatic left ventricular outflow tract obstruction after mitral valve replacement with leaflet preservation. (10461248)
1999
38
Left ventricular outflow tract obstruction as a cause for hypotension and symptoms during dobutamine stress echocardiography. (8674261)
1996
39
Severe left ventricular outflow tract obstruction despite sliding leaflet technique for repair of the mitral valve. (8691867)
1996
40
Dynamic left ventricular outflow tract obstruction as a complication of acute myocardial infarction. (8721663)
1996
41
Left ventricular outflow tract obstruction in children. (2054824)
1991
42
Accessory mitral valve leaflet causing aortic regurgitation and left ventricular outflow tract obstruction. Case report and review of published reports. (3285879)
1988
43
Surgical anatomy of left ventricular outflow tract obstruction in complete atrioventricular septal defect. A concept for operative repair. (3682859)
1987
44
Dynamic left ventricular outflow tract obstruction in cardiac amyloidosis detected by continuous-wave Doppler echocardiography. (3565277)
1987
45
Left ventricular outflow tract obstruction due to anomalous mitral valve: successful mitral valve replacement in a four month old infant. (3768218)
1986
46
Left ventricular outflow tract obstruction related to a valve prosthesis: case caused by a low-profile mitral prosthesis. (3974300)
1985
47
The surgical management of left ventricular outflow tract obstruction due to tricuspid valve pouch in complete transposition of the great arteries. (6537823)
1984
48
Effect of negative intrathoracic pressure on left ventricular outflow tract obstruction in muscular subaortic stenosis. (7193535)
1981
49
Left ventricular outflow tract obstruction due to an aneurysm of the membranous septum in a patient with pulmonary atresia and ventricular septum defect - case report. (6162222)
1980
50
Left ventricular outflow tract obstruction in transposition of the great arteries: an angiographic study of 74 cases. (453050)
1979

Genetic Variations for Left Ventricular Outflow Tract Obstruction

Expression for genes affiliated with Left Ventricular Outflow Tract Obstruction

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Left Ventricular Outflow Tract Obstruction

Search GEO for disease gene expression data for Left Ventricular Outflow Tract Obstruction.

Pathways for genes affiliated with Left Ventricular Outflow Tract Obstruction

Sources:
38NCBI BioSystems Database, 30KEGG, 12EMD Millipore, 54Reactome, 52QIAGEN
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Compounds for genes affiliated with Left Ventricular Outflow Tract Obstruction

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 24HMDB, 60Tocris Bioscience, 50PharmGKB, 2BitterDB
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Compounds related to Left Ventricular Outflow Tract Obstruction according to GeneCards/GeneDecks:

(show top 50)    (show all 90)
idCompoundScoreTop Affiliating Genes
1temocaprilat459.9ACE, AGTR1
2aliskiren45 1110.9ACE, AGTR1
3lacidipine459.9ACE, AGTR1
4saralasin459.9AGTR1, ACE
5angiotensin ii29 2410.8ACE, AGTR1
6eprosartan45 29 1111.8AGTR1, ACE
7benazepril45 1110.8AGTR1, ACE
8trandolapril45 1110.8AGTR1, ACE
9pd12331945 2910.8AGTR1, ACE
10cilazapril45 1110.8AGTR1, ACE
11bradykinin60 29 2411.8ACE, AGTR1
12olmesartan45 29 1111.8AGTR1, ACE
13eplerenone45 60 29 1112.7AGTR1, ACE
14fosinopril45 1110.7AGTR1, ACE
15quinapril45 1110.7ACE, AGTR1
16ptk787459.5VEGFA, EGFR
17chymostatin459.5ACE, AGTR1
18panitumumab45 50 1111.5VEGFA, EGFR
19betacellulin299.5EGFR, ERBB4
20epiregulin299.5EGFR, ERBB4
21hb-egf299.5ERBB4, EGFR
22zd6474459.5VEGFA, EGFR
23tamoxifen45 50 29 1112.4ERBB4, EGFR
24pd158780459.4ERBB4, EGFR
25iressa609.4ERBB4, EGFR
26ag 1478 hydrochloride609.4ERBB4, EGFR
27ag 490609.4ERBB4, EGFR
28jnj 28871063 hydrochloride609.4ERBB4, EGFR
29Vandetanib119.4EGFR, VEGFA
30lisinopril45 11 2411.4AGTR1, VEGFA, ACE
31perindopril45 50 1111.4ACE, AGTR1, VEGFA
32candesartan45 29 1111.4VEGFA, ACE, AGTR1
33pertuzumab45 50 1111.4EGFR, ERBB4
34carvedilol45 50 29 1112.4ACE, AGTR1, VEGFA
35hrgbeta1459.4ERBB4, EGFR
36everolimus50 45 1111.3EGFR, VEGFA
37su5416459.2EGFR, VEGFA
38capecitabine45 50 1111.1EGFR, VEGFA
39prostacyclin459.1ACE, AGTR1, VEGFA
40pd153035459.0EGFR, VEGFA, ERBB4
41cetuximab45 50 1110.9ERBB4, EGFR, VEGFA
42trastuzumab45 50 1110.9ERBB4, VEGFA, EGFR
43aldosterone29 11 2410.9AGTR1, EGFR
44gefitinib45 50 1110.9VEGFA, EGFR, ERBB4
45ang ii458.6ACE, VEGFA, EGFR, AGTR1
46cisplatin45 50 60 1111.4VEGFA, EGFR, AGTR1, ERBB4
47genistein45 29 60 2 11 2413.1VEGFA, EGFR, AGTR1, NOTCH1, ERBB4
48vegf458.1ERBB4, NOTCH1, VEGFA, EGFR, AGTR1
49phosphatidylinositol458.1EGFR, AGTR1, NOTCH1, ERBB4
50tyrosine457.8NOTCH1, VEGFA, EGFR, ERBB4, AGTR1

GO Terms for genes affiliated with Left Ventricular Outflow Tract Obstruction

Sources:
16Gene Ontology
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Biological processes related to Left Ventricular Outflow Tract Obstruction according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1coronary vein morphogenesisGO:0031699.9NOTCH1, VEGFA
2cardiac vascular smooth muscle cell developmentGO:0609489.9VEGFA, NOTCH1
3positive regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:0614199.8NOTCH1, VEGFA
4coronary artery morphogenesisGO:0609829.8NOTCH1, VEGFA
5regulation of systemic arterial blood pressure by renin-angiotensinGO:0030819.8AGTR1, ACE
6tube formationGO:0351489.8VEGFA, NOTCH1
7regulation of vasodilationGO:0423129.7ACE, AGTR1
8regulation of vasoconstrictionGO:0192299.6ACE, AGTR1
9cellular response to vascular endothelial growth factor stimulusGO:0359249.6NOTCH1, VEGFA
10mammary gland alveolus developmentGO:0607499.5ERBB4, VEGFA
11positive regulation of cardiac muscle cell proliferationGO:0600459.4NOTCH1, ERBB4
12branching morphogenesis of an epithelial tubeGO:0487549.4NOTCH1, VEGFA
13kidney developmentGO:0018229.3ACE, AGTR1, VEGFA
14positive regulation of MAP kinase activityGO:0434069.1EGFR, VEGFA
15positive regulation of epithelial cell proliferationGO:0506799.0NOTCH1, VEGFA, EGFR
16lactationGO:0075959.0VEGFA, ERBB4
17positive regulation of cell migrationGO:0303358.9NOTCH1, VEGFA, EGFR
18positive regulation of protein phosphorylationGO:0019348.8EGFR, ERBB4, VEGFA
19positive regulation of cell proliferationGO:0082848.3ERBB4, NOTCH1, VEGFA, EGFR

Molecular functions related to Left Ventricular Outflow Tract Obstruction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1bradykinin receptor bindingGO:0317119.6AGTR1, ACE
2receptor signaling protein tyrosine kinase activityGO:0047169.0ERBB4, EGFR
3transmembrane receptor protein tyrosine kinase activityGO:0047148.9ERBB4, EGFR
4protein heterodimerization activityGO:0469828.4AGTR1, VEGFA, EGFR
5protein bindingGO:0055157.1AGTR1, EGFR, NOTCH1, ACE, ERBB4, VEGFA

Products for genes affiliated with Left Ventricular Outflow Tract Obstruction

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Sources for Left Ventricular Outflow Tract Obstruction

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet