MCID: LFT009
MIFTS: 43

Left Ventricular Outflow Tract Obstruction malady

Category: Genetic diseases (common)

Aliases & Classifications for Left Ventricular Outflow Tract Obstruction

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Aliases & Descriptions for Left Ventricular Outflow Tract Obstruction:

Name: Left Ventricular Outflow Tract Obstruction 24 27
Hypoplastic Left Heart 24 27
Hypoplastic Left Heart Syndrome 68
Interupted Aortic Arch Type a 24
Coarctation of the Aorta 24
Aortic Valve Disease 2 68
 
Aortic Valve Stenosis 68
Bicuspid Aortic Valve 24
Aortic Valve Disorder 68
Aortic Valve Disease 24
Aortic Stenosis 24

Classifications:



Summaries for Left Ventricular Outflow Tract Obstruction

About this section
MalaCards based summary: Left Ventricular Outflow Tract Obstruction, also known as hypoplastic left heart, is related to tricuspid valve prolapse and supravalvar aortic stenosis. An important gene associated with Left Ventricular Outflow Tract Obstruction is NOTCH1 (Notch 1), and among its related pathways are Dorso-ventral axis formation and Cell adhesion_ECM remodeling. The drug alprostadil has been mentioned in the context of this disorder. Affiliated tissues include heart, liver and lung, and related mouse phenotypes are craniofacial and embryo.

Related Diseases for Left Ventricular Outflow Tract Obstruction

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Diseases related to Left Ventricular Outflow Tract Obstruction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 74)
idRelated DiseaseScoreTop Affiliating Genes
1tricuspid valve prolapse30.0EGFR, NOTCH1
2supravalvar aortic stenosis12.5
3aortic valve disease 212.4
4aortic valve disease 112.4
5familial bicuspid aortic valve12.3
6patent ductus arteriosus and bicuspid aortic valve with hand anomalies12.2
7cor triatriatum11.3
8aortic valve insufficiency11.3
9congenital heart defects, nonsyndromic, 211.2
10mitochondrial complex v deficiency, mitochondrial 111.2
11mitochondrial complex v deficiency, mitochondrial 211.2
12aortic coarctation11.1
13congenital heart defects, hamartomas of tongue, and polysyndactyly11.0
14mucopolysaccharidosis is10.9
15cardiomyopathy10.9
16transposition of the great arteries10.7
17ventricular septal defect10.6
18myocardial infarction10.5
19accessory mitral valve tissue10.4
20cardiogenic shock10.4
21acute myocardial infarction10.3
22atrioventricular septal defect10.3
23syncope10.3
24right aortic arch10.3
25ischemia10.2
26aneurysm10.2
27ovarian cystadenocarcinoma10.1EGFR, VEGFA
28spastic paraplegia 110.1EGFR, VEGFA
29spongiotic dermatitis10.1EGFR, ERBB4
30pheochromocytoma10.1
31heart disease10.1
32amyloidosis10.1
33tumor of exocrine pancreas10.1EGFR, VEGFA
34benign familial neonatal epilepsy10.1EGFR, VEGFA
35rheumatic disease10.1
36immunodeficiency due to a late component of complement deficiency10.1EGFR, VEGFA
37fallopian tube benign neoplasm10.1EGFR, NOTCH1
38anaerobic meningitis10.1EGFR, VEGFA
39cleft palate cardiac defect ectrodactyly10.0EGFR, VEGFA
40atrioventricular block10.0
41sarcoma10.0
42hypertensive heart disease10.0
43multinodular goiter10.0EGFR, VEGFA
44harrod syndrome10.0ERBB4, NOTCH1
45traumatic avascular necrosis10.0MT-ATP6, MT-ATP8
46moebius axonal neuropathy hypogonadism10.0MT-ATP6, MT-ATP8
47ocular melanoma9.9EGFR, NOTCH1, VEGFA
48interstitial lung disease9.9EGFR, VEGFA
49coronary artery disease9.9
50renal cell carcinoma9.9

Comorbidity relations with Left Ventricular Outflow Tract Obstruction via Phenotypic Disease Network (PDN):

(show top 50)    (show all 72)
Acquired ThrombocytopeniaAcute Myocardial Infarction
Aortic Valve Disease 2Aortic Valve Insufficiency
Aplastic AnemiaBenign Essential Hypertension
Chronic Myocardial IschemiaDeficiency Anemia
Disseminated Intravascular CoagulationDressler's Syndrome
GoutHemopericardium
Hypertension, EssentialHyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis
HypothyroidismIntermediate Coronary Syndrome
Iron Deficiency AnemiaIschemic Heart Disease
Active Peptic Ulcer DiseaseAcute Cystitis
Acute Kidney FailureAortic Aneurysm
Aortic AtherosclerosisAtrioventricular Block
Basilar Artery InsufficiencyBronchitis
Cardiac ArrestCardiogenic Shock
Cardiomyopathy, Familial HypertrophicCerebral Atherosclerosis
Cerebrovascular DiseaseChronic Kidney Failure
Congenital Aortic Valve InsufficiencyDecubitus Ulcer
Dental CariesEpilepsy, Focal, with Speech Disorder and with or Without Mental Retardation
EsophagitisFamilial Atrial Fibrillation
First-Degree Atrioventricular BlockGeneralized Atherosclerosis
Heart Conduction DiseaseHeart Disease
Idiopathic Interstitial PneumoniaIntracranial Embolism
Intracranial ThrombosisKidney Disease
Left Bundle Branch HemiblockMarfan Syndrome
Mesenteric Artery IschemiaMobitz Type Ii Atrioventricular Block

Graphical network of the top 20 diseases related to Left Ventricular Outflow Tract Obstruction:



Diseases related to left ventricular outflow tract obstruction

Symptoms & Phenotypes for Left Ventricular Outflow Tract Obstruction

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MGI Mouse Phenotypes related to Left Ventricular Outflow Tract Obstruction according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053829.5EGFR, ERBB4, NOTCH1, VEGFA
2MP:00053808.6EGFR, ERBB4, NOTCH1, TAB2, VEGFA
3MP:00107717.9EGFR, ERBB4, NOTCH1, TAB2, VEGFA

Drugs & Therapeutics for Left Ventricular Outflow Tract Obstruction

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Drugs for Left Ventricular Outflow Tract Obstruction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Dopamineapproved383651-61-6, 62-31-7681
Synonyms:
(3H)-Dopamine
.Beta.-(3,4-Dihydroxyphenyl)ethylamine hydrochloride
.alpha.-(3,4-Dihydroxyphenyl)-.beta.-aminoethane
1,2-Benzenediol, 4-(2-aminoethyl)- (9CI)
1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochloride
1,2-Benzenediol, 4-(2-aminoethyl)-, labeled with tritium
153C5321-5FEE-4B0B-8925-F388F0EEEBD1
2-(3,4-Dihydroxyphenyl)ethylamine
2-(3,4-dihydroxyphenyl)ethylamine
2-benzenediol
3,4-Dihydroxyphenethylamine
3,4-Dihydroxyphenethylamine hydrochloride
3,4-Dihydroxyphenylethylamine
3,4-dihydroxyphenethylamine
3-Hydroxtyramine
3-Hydroxytyramine
3-Hydroxytyramine Hydrobromide
3-Hydroxytyramine hydrochloride
4-(2-Aminoethyl)-1,
4-(2-Aminoethyl)-1,2-benzenediol
4-(2-Aminoethyl)-1,2-bezenediol
4-(2-Aminoethyl)-Pyrocatechol
4-(2-Aminoethyl)benzene-1,2-diol
4-(2-Aminoethyl)catechol
4-(2-Aminoethyl)pyrocatechol
4-(2-Aminoethyl)pyrocatechol hydrochloride
4-(2-aminoethyl)-pyrocatechol
50444-17-2
51-61-6
62-31-7 (HYDROCHLORIDE)
AC1L19S5
AC1Q54AX
AC1Q54AY
AKOS003790978
ASL 279
BIDD:ER0506
BPBio1_001123
BSPBio_001932
Biomol-NT_000001
C03758
CHEBI:18243
CHEMBL59
CID681
D07870
DB00988
Deoxyepinephrine
DivK1c_000780
Dopamin
Dopamina
Dopamina [INN-Spanish]
Dopamine
Dopamine (INN)
Dopamine (USAN)(*hydrochloride*)
Dopamine [INN:BAN]
Dopaminum
Dopaminum [INN-Latin]
Dopastat
Dophamine
Dynatra
EINECS 200-110-0
HSDB 3068
Hydroxytyramin
Hydroxytyramine
IDI1_000780
IP 498
Intropin
Intropin [*hydrochloride*]
KBio1_000780
 
KBio2_001492
KBio2_002388
KBio2_002484
KBio2_004060
KBio2_004956
KBio2_005052
KBio2_006628
KBio2_007524
KBio2_007620
KBio3_001152
KBio3_002867
KBio3_002962
KBioGR_001129
KBioGR_002388
KBioGR_002484
KBioSS_001492
KBioSS_002393
KBioSS_002491
KW-3-060
L-DOPAMINE
L000232
LDP
LS-159
Lopac-H-8502
Lopac0_000586
Medopa (TN)
MolPort-001-641-000
NCGC00015519-01
NCGC00015519-08
NCGC00096050-01
NCGC00096050-02
NCGC00096050-03
NCGC00096050-04
NCGC00096050-05
NINDS_000780
NSC 173182
NSC169105
NSC173182
Oprea1_088821
Oxytyramine
Pyrocatechol, 4-(2-aminoethyl)- (8CI)
Pyrocatechol, 4-(2-aminoethyl)-, hydrochloride
Revimine
Revivan
SPBio_001205
SPECTRUM1505155
ST048774
STK301601
Spectrum2_001023
Spectrum3_000406
Spectrum4_000525
Spectrum5_000945
Spectrum_001012
UNII-VTD58H1Z2X
UPCMLD0ENAT5885989:001
a-(3,4-Dihydroxyphenyl)-b-aminoethane
alpha-(3,4-Dihydroxyphenyl)-beta-aminoethane
cMAP_000036
cMAP_000065
dopamine
hydroxytyramine
intropin
m-Hydroxytyramine hydrochloride
nchembio.105-comp9
nchembio.107-comp4
nchembio.284-comp1
nchembio.78-comp16
nchembio.89-comp3
nchembio705-8
nchembio801-comp8
2
Ethanolapproved213764-17-5702
Synonyms:
(C6-C9)Alkyl alcohol
02483_FLUKA
02851_FLUKA
02853_FLUKA
02854_FLUKA
02855_FLUKA
02856_FLUKA
02856_SIAL
02857_FLUKA
02857_SIAL
02858_FLUKA
02858_SIAL
02860_FLUKA
02865_FLUKA
02865_SIAL
02870_FLUKA
02870_SIAL
02875_FLUKA
02877_FLUKA
02878_FLUKA
02882_FLUKA
02882_SIAL
02883_FLUKA
02884_FLUKA
02890_FLUKA
02890_SIAL
02891_FLUKA
02891_SIAL
1-Hydroxyethane
100C.NPA
121182-78-3
187380_ALDRICH
187380_SIAL
24102_RIEDEL
24102_SIAL
24103_RIEDEL
24103_SIAL
24105_RIEDEL
24105_SIAL
24106_RIEDEL
24106_SIAL
24194_RIEDEL
24194_SIAL
245119_ALDRICH
245119_SIAL
270741_ALDRICH
270741_SIAL
277649_ALDRICH
277649_SIAL
2858_SIGMA
29221_FLUKA
32205_RIEDEL
32205_SIAL
32221_RIEDEL
32221_SIAL
32294_RIEDEL
32294_SIAL
34870_SIAL
34963_RIEDEL
39278_FLUKA
40210_ALDRICH
40210_RIEDEL
41322_FLUKA
458600_ALDRICH
458600_SIAL
459828_ALDRICH
459828_SIAL
459836_ALDRICH
459836_SIAL
459844_SIAL
48075_SUPELCO
493511_SIAL
493538_ALDRICH
493538_SIAL
493546_ALDRICH
493546_SIAL
64-17-5
676829_SIAL
68475-56-9
71076-86-3
71329-38-9
8000-16-6
8024-45-1
AC1L19TW
AC1Q31MM
AHD 2000
AI3-01706
ALCOHOL 5% IN D5-W
Absolute Alcohol
Absolute Ethanol
Absolute alcohol
Absolute ethanol
Absolute ethyl alcohol
Aethanol
Aethanol [German]
Aethylalkohol
Alcare Hand Degermer
Alcohol
Alcohol (USP)
Alcohol (ethyl)
Alcohol Anhydrous
Alcohol [USP]
Alcohol anhydrous
Alcohol dehydrated
Alcohol denatured
Alcohol etílico
Alcohol, Absolute
Alcohol, Dehydrated
Alcohol, Diluted
Alcohol, Grain
Alcohol, anhydrous
Alcohol, dehydrated
Alcohol, denatured
Alcohol, diluted
Alcohol, ethyl
Alcohols
Alcohols, C1-3
Alcohols, C30
Alcohols, C6-9
Alcool Ethylique
Alcool Etilico
Alcool ethylique
Alcool etilico
Alcool éthylique
Algrain
Alkohol
Alkohol [German]
Alkoholu Etylowego
Alkoholu etylowego
Aminoethanol
Anhydrol
Anhydrol PM 4085
Anhydrous alcohol
Anhydrous ethanol
Beta-Aminoethanol
Beta-Aminoethyl Alcohol
Beta-Ethanolamine
Beta-Hydroxyethylamine
C00469
C2H5OH
C2H6O
CCRIS 945
CDA 19
CDA 19-200
CHEBI:16236
CHEMBL545
CID702
Caswell No. 426
Caswell No. 430
Colamine
Cologne Spirit
Cologne spirit
Cologne spirits
 
D000431
D00068
DB00898
Dehydrated Ethanol
Dehydrated alcohol
Dehydrated ethanol
Denatured Alcohol
Denatured Alcohol Cd-10
Denatured Alcohol Cd-5
Denatured Alcohol Cd-5a
Denatured Alcohol Sd-1
Denatured Alcohol Sd-13a
Denatured Alcohol Sd-17
Denatured Alcohol Sd-23a
Denatured Alcohol Sd-28
Denatured Alcohol Sd-30
Denatured Alcohol Sd-39b
Denatured Alcohol Sd-39c
Denatured Alcohol Sd-3a
Denatured Alcohol Sd-40m
Denatured Ethanol
Denatured alcohol
Denatured ethanol
Desinfektol EL
Diluted Alcohol
Distilled spirits
E2385_SIGMA
E7023_ALDRICH
E7023_SIAL
E7148_ALDRICH
E7148_SIAL
E7517_SIGMA
EINECS 200-578-6
EINECS 270-649-4
EOH
EOX
ETA
Envision Conditioner Pdd 9020
Esumiru WK 88
EtOH
Etanolo
Etanolo [Italian]
Ethanol (9CI)
Ethanol 200 Proof
Ethanol 200 proof
Ethanol Absolute
Ethanol Absolute Bp
Ethanol Anhydrous
Ethanol Extra Pure
Ethanol Vapor
Ethanol [JAN]
Ethanol solution
Ethanol, Silent Spirit
Ethanol, undenatured
Ethanolum anhydricum
Ethicap
Ethyl Alcohol
Ethyl Alcohol & Water, 10%
Ethyl Alcohol & Water, 20%
Ethyl Alcohol & Water, 30%
Ethyl Alcohol & Water, 40%
Ethyl Alcohol & Water, 5%
Ethyl Alcohol & Water, 50%
Ethyl Alcohol & Water, 60%
Ethyl Alcohol & Water, 70%
Ethyl Alcohol & Water, 80%
Ethyl Alcohol & Water, 95%
Ethyl Alcohol & Water, 96%
Ethyl Alcohol Anhydrous
Ethyl Alcohol, Anhydrous
Ethyl Alcohol, Denatured
Ethyl Hydrate
Ethyl Hydroxide
Ethyl alc
Ethyl alcohol
Ethyl alcohol anhydrous
Ethyl alcohol in alcoholic beverages
Ethyl alcohol usp
Ethyl hydrate
Ethyl hydroxide
Ethylalcohol
Ethylalcohol [Dutch]
Ethylol
Ethylolamine
Ethyloxy Group
Etylowy alkohol
FEMA No. 2419
FEMA Number 2419
Fermentation alcohol
Glycinol
Grain alcohol
HSDB 531
HSDB 82
HYDROXYETHYL GROUP
Hinetoless
Hydroxyethane
I14-12648
IMS 99
Infinity Pure
Jaysol
Jaysol S
LS-1539
LTBB002977
Lux
Methylated Spirit Mineralised
Methylated spirit
Methylcarbinol
MolPort-001-785-844
Molasses alcohol
NCGC00091458-01
NCI-C03134
NSC 85228
NSC85228
Oxydimethylene Group
Potato alcohol
Punctilious ethyl alcohol
Pyro
QMHAIh@
Reagent Alcohol
Ru-Tuss Expectorant
SDA 3A
SDA 40-2
SDM No. 37
SY Fresh M
Sekundasprit
Silent spirit
Spirit
Spirits of wine
Spiritus vini
Spirt
Synasol
Tecsol
Tecsol C
Thanol
Thiofaco M-50
UNII-3K9958V90M
USAF EK-1597
Undenatured Ethanol
WLN: Q2
absolute alcohol
alcohol
alcohol etilico
bmse000297
etanol
ethanol
ethyl alcohol
grain alcohol
nchem.651-comp3c
nchembio.552-comp10
nchembio.94-comp20
spiritus vini
Äthanol
Äthylalkohol
éthanol
3
Bupropionapproved32934841-39-9, 34911-55-2444
Synonyms:
( -)-2-(tert-Butylamino)-3'-chloropropiophenone
( -)-2-(tert-Butylamino)-3'-chlorpropiophenon
(+-)-1-(3-chlorophenyl)-2-((1,1-dimethylethyl)amino)-1-propanone
(+-)-Bupropion
.alpha.-(tert-Butylamino)-m-chloropropiophenone
1-(3-chlorophenyl)-2-[(1,1-dimethylethyl)amino]propan-1-one
2-(Tert-Butylamino)-3'-chloropropiophenone
2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one
34841-36-6 (hydrochloride)
34841-39-9
34911-55-2
AB00053756
AC-197
AC1L198Y
AMFEBUTAMONE HCl
Amfebutamon
Amfebutamona
Amfebutamona [INN-Spanish]
Amfebutamone
Amfebutamonum
Amfebutamonum [INN-Latin]
BPBio1_000042
BRD-A05186015-003-05-7
BRN 2101062
BSPBio_000038
BSPBio_002247
Bupropion (INN)
Bupropion (Old RN)
Bupropion (USAN)
Bupropion Hcl
Bupropion SR
Bupropion [INN:BAN]
Bupropion hydrocloride
C06860
CHEBI:3219
CHEMBL894
CID444
CPD000472526
D07591
DB01156
DivK1c_007050
Elont
 
HMS2051G10
HMS2089G14
Jsp006301
KBio1_001994
KBio2_002143
KBio2_004711
KBio2_007279
KBio3_001467
KBioGR_001168
KBioSS_002143
L000725
LS-122817
Lopac0_000166
MLS001424015
MolPort-003-845-432
NCGC00015122-06
NCGC00089751-02
NCI60_002714
NSC315851
Prestwick0_000249
Prestwick1_000249
Prestwick2_000249
Prestwick3_000249
SAM001246699
SMR000472526
SPBio_001817
SPBio_002257
SpecPlus_000954
Spectrum2_001659
Spectrum3_000644
Spectrum4_000614
Spectrum5_001406
Spectrum_001663
TL8002604
UNII-01ZG3TPX31
Wellbatrin
Wellbutrin
Wellbutrin SR
Wellbutrin XL
Zyban
alpha-(tert-butylamino)-m-chloropropiophenone
amfebutamonum
bupropion
4
Caffeineapproved, Nutraceutical39658-08-22519
Synonyms:
07E4FB58-FD79-4175-8E3D-05BF96954522
1,3,7-Trimethyl-2,6-dioxopurine
1,3,7-Trimethyl-3,7-dihydro-1H-purine-2,6-dione
1,3,7-Trimethylpurine-2,6-dione
1,3,7-Trimethylxanthine
1,3,7-trimethyl-2,6-dioxopurine
1,3,7-trimethylpurine-2,6-dione
1,3,7-trimethylxanthine
1-3-7-TRIMETHYLXANTHINE
1-Methyl-Theobromine
1-methyltheobromine
137X
1gfz
1l5q
1l7x
27602_FLUKA
2a3b
3,7-Dihydro-1,3,7-trimethyl-1H-purin-2,6-dion
3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione
3,7-dihydro-1,3,7-trimethyl-1H-purine
5-26-13-00558 (Beilstein)
58-08-2
7-Methyl Theophylline
7-Methyltheophylline
7-methyltheophylline
71701-02-5
75035_FLUKA
95789-13-2
A.S.A. and Codeine Compound
AC-12774
AC1L1DV2
AC1Q3Z23
ACon1_000085
AI3-20154
AKOS000121334
Alert-Pep
Alert-pep
Anacin Maximum Strength
Anhydrous caffeine
Anhydrous caffeine (JP15)
Anhydrous caffeine (TN)
Anoquan
BIDD:ER0554
BIDD:GT0632
BIDD:PXR0172
BIM-0050216.0001
BRD-K02404261-001-02-7
BRD-K02404261-001-03-5
BRN 0017705
BSPBio_001921
Berlin-Chemie Brand of Caffeine
Bio-0579
Bio1_000473
Bio1_000962
Bio1_001451
Bristol-Myers Squibb Brand of Caffeine
C 0750
C07481
C0750_SIAL
C1778_SIAL
C2042
C6035_FLUKA
C6035_SIGMA
C7731_SIAL
C8960_SIAL
CCRIS 1314
CFF
CHEBI:27732
CHEMBL113
CID2519
CU-01000012617-3
Cafamil
Cafcit
Cafecon
Cafeina
Cafergot
Cafeína
Caffedrine
Caffedrine Caplets
Caffein
Caffeina
Caffeina [Italian]
Caffeine (USP)
Caffeine (natural)
Caffeine Pure
Caffeine [BAN:JAN]
Caffeine solution
Caffeine, Anhydrous
Caffeine, Monohydrate
Caffeine, Synthetic
Caffeine, anhydrous
Caffeine, synthetic
Caffeinum
Caffine
Cafipel
Caféine
Coffein
Coffein [German]
Coffeine
Coffeinum
Coffeinum N
Coffeinum Purrum
Compound 65
D002110
D00528
DB00201
DHC Plus
DHCplus
Darvon Compound
Darvon Compound-65
Dasin
Dexitac
Dexitac Stay Alert Stimulant
Dhc Plus
Diurex
DivK1c_000730
Durvitan
EINECS 200-362-1
EU-0100228
Eldiatric C
Enerjets
Ercatab
Esgic
Esgic-Plus
FEMA No. 2224
Femcet
Fioricet
Fiorinal
GlaxoSmithKline Brand of Caffeine
Guaranine
HMS1920I09
HMS2091O11
HMS502E12
HSDB 36
Hycomine
Hycomine Compound
I14-4386
 
IDI1_000730
Invagesic
Invagesic Forte
KBio1_000730
KBio2_001781
KBio2_004349
KBio2_006917
KBio3_001141
KBioGR_002325
KBioSS_001781
Keep Alert
Kofein
Kofein [Czech]
Koffein
Koffein [German]
L000155
LS-237
Lanorinal
Lopac-C-0750
Lopac0_000228
MEGxp0_001350
MLS001055341
MLS001056714
MLS001066409
Mateina
Mateína
Maximum Strength Snapback Stimulant Powders
Medigesic Plus
Merck dura Brand of Caffeine
Methyltheobromide
Methyltheobromine
Methylxanthine theophylline
Midol Maximum Strength
Migergot
Miudol
MolMap_000054
MolPort-000-730-850
Monohydrate Caffeine
Monomethyl Derivative of Theophylline
Monomethyl derivative of Theophylline
NCGC00015208-01
NCGC00015208-02
NCGC00015208-04
NCGC00015208-14
NCGC00090699-01
NCGC00090699-02
NCGC00090699-03
NCGC00090699-04
NCGC00090699-05
NCGC00090699-06
NCGC00090699-07
NCGC00090699-08
NCGC00090699-09
NCGC00168808-01
NCGC00168808-02
NCI-C02733
NCIOpen2_008255
NINDS_000730
NSC 5036
NSC5036
Natural Caffeinum
Nix Nap
No Doz
No-Doz
Nodaca
Nodoz Maximum Strength Caplets
Norgesic
Norgesic Forte
Organex
Orphengesic
Orphengesic Forte
P-A-C Analgesic Tablets
PDSP1_001016
PDSP1_001235
PDSP2_001000
PDSP2_001219
Passauer Brand of Caffeine
Pep-Back
Percoffedrinol N
Percutafeine
Phensal
Pierre Fabre Brand of Caffeine
Probes1_000150
Probes2_000128
Propoxyphene
Propoxyphene Compound 65
Propoxyphene Compound-65
Quick Pep
Quick-Pep
Refresh'n
Republic Drug Brand of Caffeine
SDCCGMLS-0064595.P001
SDCCGMLS-0064595.P002
SK 65 Compound
SK-65 Compound
SMR000326667
SPBio_001222
SPECTRUM1500155
STK177283
Seid Brand of Caffeine
Spectrum2_001261
Spectrum3_000321
Spectrum4_001782
Spectrum5_000423
Spectrum_001301
Stim
Synalgos-Dc
TNP00310
Thein
Theine
Theobromine ME
Theobromine Me
Theophylline ME
Theophylline Me
Theophylline, 7-methyl
Thompson Brand 1 of Caffeine
Thompson Brand 2 of Caffeine
Tirend
Tri-Aqua
Triad
UNII-3G6A5W338E
Ultra Pep-Back
Vivarin
W222402_ALDRICH
WLN: T56 BN DN FNVNVJ B1 F1 H1
Wake-Up
Wigraine
Xanthine, 1,3,7-trimethyl
ZINC00001084
bmse000206
cafeine
caffeine
caffenium
component of Cafergot
nchembio.243-comp7
nchembio.63-comp5
nchembio774-comp2
teina
teína
5Vitamins5282
6Psychotropic Drugs6430
7Neurotransmitter Agents18340
8Neurotransmitter Uptake Inhibitors3521
9Antidepressive Agents2736
10Dopamine Uptake Inhibitors1331
11Dopamine Agents3836
12Antidepressive Agents, Tricyclic304
13Antidepressive Agents, Second-Generation1311
14Cytochrome P-450 Enzyme Inhibitors3917
15Cytochrome P-450 CYP2D6 Inhibitors727
16Tin Fluorides264
17diuretics1418
18Immunoglobulins6394
19Antibodies6394
20Kavanutraceutical1619000-38-8

Interventional clinical trials:

(show all 14)
idNameStatusNCT IDPhase
1Hypertrophic Cardiomyopathy Symptom Release by BX1514MCompletedNCT02590809Phase 2
2A Phase 2 Open-label Pilot Study Evaluating MYK-461 in Subjects With Symptomatic Hypertrophic Cardiomyopathy and Left Ventricular Outflow Tract ObstructionRecruitingNCT02842242Phase 2
3NHLBI DIR LAMPOON Study: Intentional Laceration of the Anterior Mitral Leaflet to Prevent Left Ventricular Outflow Tract Obstruction During Transcatheter Mitral Valve ImplantationNot yet recruitingNCT03015194Phase 2
4Water- and Salt-homeostasis in Healthy Humans, and in Patients With Heart- or Lung DiseaseUnknown statusNCT00830726
5Right Ventricular Outflow Tract StudyCompletedNCT01294839
6Long-Term Results of DDD Pacing in Obstructive Hypertrophic CardiomyopathyCompletedNCT00001530
7Bupropion & Cardio Birth Defect (Slone)CompletedNCT01597661
8Stress Echo 2020 - The International Stress Echo StudyRecruitingNCT03049995
9Triple Chamber Pacing in Hypertrophic Obstructive Cardiomyopathy (HOCM) Patients - TRICHAMPION STUDYRecruitingNCT01614717
10Multi Modal Cardiac Imaging Prior Transcatheter Aortic Valve ImplantationRecruitingNCT01805739
11Comparison Between Standard and Ultrasound Integrated Approach for Risk Stratification of Syncope in the Emergency DepartmentRecruitingNCT02781207
12Pilot Trial: Comparison of Flow PatternsRecruitingNCT02288871
13Evaluation of Panel Reactive Antibody in Children Following Stage I Palliation for Hypoplastic Left Heart SyndromeActive, not recruitingNCT01135485
14Cardiac Rehabilitation in Patients With HCM Without LV Outflow Tract Obstruction With Preserved EF - Pilot StudyNot yet recruitingNCT03178357

Search NIH Clinical Center for Left Ventricular Outflow Tract Obstruction

Inferred drug relations via UMLS68/NDF-RT46:

Genetic Tests for Left Ventricular Outflow Tract Obstruction

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Genetic tests related to Left Ventricular Outflow Tract Obstruction:

id Genetic test Affiliating Genes
1 Left Ventricular Outflow Tract Obstruction (lvoto)27 24 NOTCH1
2 Hypoplastic Left Heart27

Anatomical Context for Left Ventricular Outflow Tract Obstruction

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MalaCards organs/tissues related to Left Ventricular Outflow Tract Obstruction:

36
Heart, Liver, Lung, Testes

Publications for Left Ventricular Outflow Tract Obstruction

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Articles related to Left Ventricular Outflow Tract Obstruction:

(show top 50)    (show all 483)
idTitleAuthorsYear
1
Left ventricular outflow tract obstruction-be prepared! (28072930)
2017
2
Excision of anomalous muscle bundles as an important addition to extended septal myectomy for treatment of left ventricular outflow tract obstruction. (27033027)
2016
3
Intentional Laceration of the Anterior Mitral Valve Leaflet to Prevent Left Ventricular Outflow Tract Obstruction During Transcatheter MitralA Valve Replacement: Pre-Clinical Findings. (27609260)
2016
4
Dynamic left ventricular outflow tract obstruction in recovery process of stress cardiomyopathy. (27064643)
2016
5
Left Ventricular Outflow Tract Obstruction After Transcatheter Mitral Valve-in-Ring Implantation: A Word of Caution. (27847064)
2016
6
Esmolol for Patients with Takotsubo Syndrome and Left Ventricular Outflow Tract Obstruction. (27101106)
2016
7
Fixed versus dynamic left ventricular outflow tract obstruction: Res ipsa loquitur. (26682620)
2016
8
Evaluation of Left Ventricular Outflow Tract Obstruction With Four-Dimensional Phase Contrast Magnetic Resonance Imaging in Patients with Hypertrophic Cardiomyopathy-A Pilot Study. (27529682)
2016
9
Severe left ventricular outflow tract obstruction. (27261208)
2016
10
Percutaneous alcohol septal ablation to acutely reduce left ventricular outflow tract obstruction induced by transcatheter mitral valve replacement. (27377756)
2016
11
Surgery for Left Ventricular Outflow Tract Obstruction with a Relatively Thin Interventricular Septum. (26757211)
2016
12
Summary of Clinical Experience of Modified Double Root Translocation in the Management of Complete Transposition of Great Arteries With Left Ventricular Outflow Tract Obstruction. (27396558)
2016
13
Intracardiac tumor causing left-ventricular outflow-tract obstruction in a newborn. (27358535)
2016
14
Technique to avoid left ventricular outflow tract obstruction. (26993109)
2016
15
Left ventricular outflow tract obstruction in ICU patients. (27054628)
2016
16
Refractory Hypotension after Liver Allograft Reperfusion: A Case of Dynamic Left Ventricular Outflow Tract Obstruction. (26909349)
2016
17
Late Left Ventricular Outflow Tract Obstruction Following the Rastelli Operation: Expectations Out to 20 Years. (27587496)
2016
18
Influence of apical position on the left ventricular outflow tract obstruction in congenitally corrected transposition. (27842759)
2016
19
TCT-813 Alcohol Septal Ablation in patients with Left Ventricular Outflow Tract Obstruction after Transcatheter Mitral Valve Replacement for Mitral Annular Calcification (TMVR in MAC). (27970202)
2016
20
Left Ventricular Outflow Tract Obstruction: Coarctation of the Aorta, Interrupted Aortic Arch, and Borderline Left Ventricle. (27490616)
2016
21
Cardiogenic Shock Following Amplatzer Device Embolization Due to Left Ventricular Outflow Tract Obstruction. (26748636)
2016
22
Manifestation of Latent Left Ventricular Outflow Tract Obstruction in the Acute Phase of Takotsubo Cardiomyopathy. (27904102)
2016
23
Fixed left ventricular outflow tract obstruction mimicking hypertrophic obstructive cardiomyopathy: pitfalls in diagnosis. (27613242)
2016
24
Long mitral valve leaflets determine left ventricular outflow tract obstruction during exercise in hypertrophic cardiomyopathy. (27031819)
2016
25
Current mid-term outcome with an integrated surgical strategy for correction of d-transposition of the great arteries with ventricular septal defect and left ventricular outflow tract obstruction. (27009103)
2016
26
Hemodynamic Effects, Safety, and Feasibility of Intravenous Esmolol Infusion During Takotsubo Cardiomyopathy With Left Ventricular Outflow Tract Obstruction: Results From A Multicenter Registry. (26946520)
2016
27
Pannus of Mitral Valve Prosthesis Causing Left Ventricular Outflow Tract Obstruction. (27826376)
2016
28
Latent Left Ventricular Outflow Tract Obstruction Due to Accessory Mitral Valve in a 12-Year-Old Boy. (27471367)
2016
29
Pregnancy in Hypertrophic Cardiomyopathy with Severe Left Ventricular Outflow Tract Obstruction. (27358709)
2016
30
A Small Molecule Inhibitor of Sarcomere Contractility Acutely Relieves Left Ventricular Outflow Tract Obstruction in Feline Hypertrophic Cardiomyopathy. (27973580)
2016
31
Case of Ebstein Anomaly Complicated by Left Ventricular Outflow Tract Obstruction Secondary to Deformed Basal Septum Attributable to Atrialized Right Ventricle. (26811277)
2016
32
Hybrid stenting for left ventricular outflow tract obstruction in congenitally corrected transposition of the great arteries. (27938457)
2016
33
TCT-642 Intentional Laceration of the Anterior Mitral valve leaflet to Prevent left ventricular Outflow tract ObstructioN (LAMPOON) during transcatheter mitral valve implantation: preclinical findings. (27970020)
2016
34
All Shock States Are Not the Same. Systolic Anterior Motion of Mitral Valve Causing Left Ventricular Outflow Tract Obstruction in Septic Shock. (27726435)
2016
35
Son of SAM: Left ventricular outflow tract obstruction with coexistent mitral stenosis and hypertrophic cardiomyopathy. (26790355)
2016
36
Subacute left ventricular outflow tract obstruction after transapical closure of a mitral paravalvular leak in the region of the aortomitral curtain. (27576330)
2016
37
Left Ventricular Outflow Tract Obstruction in Aortic Arch Anomalies With Ventricular Septal Defect. (26952292)
2016
38
Echocardiographic Predictors of Left Ventricular Outflow Tract Obstruction following Repair of Atrioventricular Septal Defect. (27834986)
2016
39
Factors influencing left ventricular outflow tract obstruction following a mitral valve-in-valve or valve-in-ring procedure, part 1. (26386239)
2015
40
Provocation of left ventricular outflow tract obstruction using nitrate inhalation in hypertrophic cardiomyopathy: Relation to electromechanical delay. (26779503)
2015
41
Clinical impact of left ventricular outflow tract obstruction in takotsubo cardiomyopathy. (25739572)
2015
42
Takotsubo cardiomyopathy and left ventricular outflow tract obstruction. (25739937)
2015
43
Left ventricular outflow tract obstruction and Takotsubo syndrome: A heretofore unsettled pathophysiologic association. (25889328)
2015
44
Effect of Left Ventricular Outflow Tract Obstruction on Left Atrial Mechanics in Hypertrophic Cardiomyopathy. (26788503)
2015
45
Selective management strategy of interrupted aortic arch mitigates left ventricular outflow tract obstruction risk. (26520007)
2015
46
Dynamic left ventricular outflow tract obstruction secondary to hypovolemia in a German Shepard dog with splenic hemangiosarcoma. (25924797)
2015
47
Primary cardiac synovial sarcoma originating from the mitral valve causing left ventricular outflow tract obstruction. (26115156)
2015
48
Dynamic left ventricular outflow tract obstruction causing myocardial ischemia. (25438213)
2015
49
Emergency echocardiography to guide therapy in a patient with Takotsubo cardiomyopathy complicated with dynamic left ventricular outflow tract obstruction. (26521838)
2015
50
Ventricular tachycardia and syncope: a complication of an echinococcal cyst caused by left ventricular outflow tract obstruction. (25550268)
2015

Variations for Left Ventricular Outflow Tract Obstruction

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Expression for genes affiliated with Left Ventricular Outflow Tract Obstruction

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Search GEO for disease gene expression data for Left Ventricular Outflow Tract Obstruction.

Pathways for genes affiliated with Left Ventricular Outflow Tract Obstruction

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GO Terms for genes affiliated with Left Ventricular Outflow Tract Obstruction

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Cellular components related to Left Ventricular Outflow Tract Obstruction according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial proton-transporting ATP synthase complexGO:00057539.9MT-ATP6, MT-ATP8
2proton-transporting ATP synthase complex, coupling factor F(o)GO:00452639.9MT-ATP6, MT-ATP8
3receptor complexGO:00432359.2EGFR, ERBB4, NOTCH1

Biological processes related to Left Ventricular Outflow Tract Obstruction according to GeneCards Suite gene sharing:

(show all 30)
idNameGO IDScoreTop Affiliating Genes
1cell fate commitmentGO:004516510.4ERBB4, NOTCH1
2cellular response to epidermal growth factor stimulusGO:007136410.4EGFR, ERBB4
3ERBB2 signaling pathwayGO:003812810.4EGFR, ERBB4
4positive regulation of cardiac muscle cell proliferationGO:006004510.4ERBB4, NOTCH1
5branching morphogenesis of an epithelial tubeGO:004875410.3NOTCH1, VEGFA
6cardiac vascular smooth muscle cell developmentGO:006094810.3NOTCH1, VEGFA
7cellular response to vascular endothelial growth factor stimulusGO:003592410.3NOTCH1, VEGFA
8coronary artery morphogenesisGO:006098210.3NOTCH1, VEGFA
9coronary vein morphogenesisGO:000316910.3NOTCH1, VEGFA
10negative regulation of ERBB signaling pathwayGO:190118510.3EGFR, ERBB4
11peptidyl-tyrosine autophosphorylationGO:003808310.3EGFR, ERBB4
12lactationGO:000759510.3ERBB4, VEGFA
13mammary gland alveolus developmentGO:006074910.2ERBB4, VEGFA
14positive regulation of neuroblast proliferationGO:000205210.2NOTCH1, VEGFA
15positive regulation of MAP kinase activityGO:004340610.2EGFR, VEGFA
16positive regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:006141910.1NOTCH1, VEGFA
17ATP biosynthetic processGO:000675410.1MT-ATP6, MT-ATP8
18ATP synthesis coupled proton transportGO:001598610.1MT-ATP6, MT-ATP8
19mitochondrial ATP synthesis coupled proton transportGO:004277610.1MT-ATP6, MT-ATP8
20regulation of cell motilityGO:200014510.0EGFR, ERBB4
21positive regulation of tyrosine phosphorylation of STAT proteinGO:004253110.0ERBB4, VEGFA
22lung developmentGO:00303249.9EGFR, NOTCH1, VEGFA
23positive regulation of cell migrationGO:00303359.9EGFR, NOTCH1, VEGFA
24positive regulation of epithelial cell proliferationGO:00506799.8EGFR, NOTCH1, VEGFA
25positive regulation of protein phosphorylationGO:00019349.6EGFR, ERBB4, VEGFA
26tube formationGO:00351489.6NOTCH1, VEGFA
27heart developmentGO:00075079.6ERBB4, NOTCH1, TAB2
28response to hyperoxiaGO:00550939.5MT-ATP6, MT-ATP8
29multicellular organism developmentGO:00072759.4EGFR, ERBB4, NOTCH1, VEGFA
30positive regulation of cell proliferationGO:00082849.4EGFR, ERBB4, NOTCH1, VEGFA

Molecular functions related to Left Ventricular Outflow Tract Obstruction according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1phosphatidylinositol-4,5-bisphosphate 3-kinase activityGO:004693410.1EGFR, ERBB4
2signal transducer, downstream of receptor, with protein tyrosine kinase activityGO:000471610.1EGFR, ERBB4
3hydrogen ion transmembrane transporter activityGO:00150789.9MT-ATP6, MT-ATP8
4transmembrane receptor protein tyrosine kinase activityGO:00047149.6EGFR, ERBB4

Sources for Left Ventricular Outflow Tract Obstruction

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet