MCID: LFT009
MIFTS: 41

Left Ventricular Outflow Tract Obstruction malady

Cardiovascular diseases category

Summaries for Left Ventricular Outflow Tract Obstruction

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MalaCards: Left Ventricular Outflow Tract Obstruction, also known as hypoplastic left heart syndrome, is related to acute myocardial infarction and congenital heart defect. An important gene associated with Left Ventricular Outflow Tract Obstruction is NOTCH1 (notch 1), and among its related pathways are Heart Development and Dorso-ventral axis formation. The drug alprostadil and the compounds temocaprilat and aliskiren have been mentioned in the context of this disorder. Affiliated tissues include heart, and related mouse phenotypes are endocrine/exocrine gland and tumorigenesis.

Aliases & Classifications for Left Ventricular Outflow Tract Obstruction

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60UMLS, 20GeneTests, 22GTR, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

left ventricular outflow tract obstruction 20 22
hypoplastic left heart syndrome 60
aortic valve stenosis 60
aortic valve disorder 60


External Ids:

ICD1025 I39.1

Related Diseases for Left Ventricular Outflow Tract Obstruction

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17GeneCards, 18GeneDecks
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Diseases related to Left Ventricular Outflow Tract Obstruction via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 188)
idRelated DiseaseScoreTop Affiliating Genes
1acute myocardial infarction31.3ACE, AGTR1
2congenital heart defect30.8AGTR1, NOTCH1, ACE, VEGFA
3mitral valve prolapse30.7AGTR1
4hypertensive heart disease30.7AGTR1, ACE
5hypertension30.7NOTCH1, AGTR1, ACE
6adenocarcinoma30.5EGFR, AGTR1, VEGFA, NOTCH1, ERBB4
7arthritis30.4AGTR1
8dilated cardiomyopathy30.2ACE
9hypertrophic cardiomyopathy11.2
10ventricular septal defect11.1
11myocardial infarction11.0
12atrioventricular septal defect10.8
13image syndrome10.8
14alcoholic cardiomyopathy10.7
15double outlet right ventricle10.7
16atrioventricular block10.6
17ischemia10.6
18heart aneurysm10.6
19hypoplastic left heart syndrome 110.6
20carotid stenosis10.6
21rheumatic aortic valve stenosis10.5
22mitral valve insufficiency10.5
23amyloidosis10.5
24aortic valve stenosis10.5
25heart septal defect10.5
26pheochromocytoma10.5
27tricuspid valve stenosis10.5
28hypoplastic left heart syndrome 210.5
29angiodysplasia10.4
30kabuki syndrome10.4
31alkaptonuria10.4
32ochronosis10.4
33aortic atherosclerosis10.4
34atherosclerosis10.4
35heart valve disease10.4
36pneumonia10.4
37mitral valve stenosis10.4
38cerebritis10.4
39tricuspid valve prolapse10.4
40hypoplastic left heart syndrome10.4
41diastolic heart failure10.4
42inferior myocardial infarction10.4
43fabry disease10.4
44aortic incompetence10.4
45aortic valve insufficiency10.4
46hemiplegia10.4
47hemolytic anemia10.4
48liposarcoma10.4
49lung adenocarcinoma10.4
50mitral valve disease10.4

Graphical network of the top 20 diseases related to Left Ventricular Outflow Tract Obstruction:



Diseases related to left ventricular outflow tract obstruction

Clinical Features for Left Ventricular Outflow Tract Obstruction

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Drugs & Therapeutics for Left Ventricular Outflow Tract Obstruction

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Left Ventricular Outflow Tract Obstruction

Search CenterWatch for Left Ventricular Outflow Tract Obstruction

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Left Ventricular Outflow Tract Obstruction

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20GeneTests, 22GTR
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Genetic tests related to Left Ventricular Outflow Tract Obstruction:

id Genetic test Affiliating Genes
1 Left Ventricular Outflow Tract Obstruction (lvoto)20 22 NOTCH1

Anatomical Context for Left Ventricular Outflow Tract Obstruction

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32MalaCards
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MalaCards organs/tissues related to Left Ventricular Outflow Tract Obstruction:

32
Heart

Animal Models for Left Ventricular Outflow Tract Obstruction or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Left Ventricular Outflow Tract Obstruction:

36 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.3NOTCH1
2MP:00020069.8EGFR
3MP:00053699.3ERBB4, NOTCH1
4MP:00053708.3EGFR, VEGFA, NOTCH1, ACE
5MP:00053828.2ERBB4, NOTCH1, VEGFA, EGFR
6MP:00053888.1EGFR, VEGFA, NOTCH1, ERBB4
7MP:00053678.0EGFR, AGTR1, VEGFA, NOTCH1, ACE
8MP:00053787.7ACE, NOTCH1, VEGFA, AGTR1, EGFR
9MP:00053977.7EGFR, VEGFA, NOTCH1, ACE, ERBB4
10MP:00053857.4ERBB4, ACE, NOTCH1, VEGFA, AGTR1, EGFR
11MP:00053877.4EGFR, AGTR1, VEGFA, NOTCH1, ACE, ERBB4
12MP:00107687.3EGFR, AGTR1, VEGFA, NOTCH1, ACE, ERBB4
13MP:00053847.3EGFR, VEGFA, NOTCH1, ACE, ERBB4

Publications for Left Ventricular Outflow Tract Obstruction

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Genetic Variations for Left Ventricular Outflow Tract Obstruction

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Expression for genes affiliated with Left Ventricular Outflow Tract Obstruction

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Left Ventricular Outflow Tract Obstruction

Search GEO for disease gene expression data for Left Ventricular Outflow Tract Obstruction.

Pathways for genes affiliated with Left Ventricular Outflow Tract Obstruction

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37NCBI BioSystems Database, 29KEGG, 12EMD Millipore, 53Reactome, 51QIAGEN
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Compounds for genes affiliated with Left Ventricular Outflow Tract Obstruction

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Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 24HMDB, 59Tocris Bioscience, 49PharmGKB, 2BitterDB
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Compounds related to Left Ventricular Outflow Tract Obstruction according to GeneCards/GeneDecks:

(show top 50)    (show all 90)
idCompoundScoreTop Affiliating Genes
1temocaprilat449.9AGTR1, ACE
2aliskiren44 1110.9AGTR1, ACE
3lacidipine449.9AGTR1, ACE
4angiotensin ii28 2410.9AGTR1, ACE
5saralasin449.8AGTR1, ACE
6eprosartan44 28 1111.8AGTR1, ACE
7benazepril44 1110.8AGTR1, ACE
8cilazapril44 1110.8AGTR1, ACE
9trandolapril44 1110.8AGTR1, ACE
10pd12331944 2810.8AGTR1, ACE
11bradykinin59 28 2411.8ACE, AGTR1
12eplerenone44 59 28 1112.8AGTR1, ACE
13fosinopril44 1110.7AGTR1, ACE
14olmesartan44 28 1111.7AGTR1, ACE
15quinapril44 1110.7ACE, AGTR1
16ptk787449.5EGFR, VEGFA
17panitumumab44 49 1111.5EGFR, VEGFA
18zd6474449.5EGFR, VEGFA
19hb-egf289.5EGFR, ERBB4
20epiregulin289.5EGFR, ERBB4
21betacellulin289.5EGFR, ERBB4
22tamoxifen44 49 28 1112.4ERBB4, EGFR
23Vandetanib119.4EGFR, VEGFA
24jnj 28871063 hydrochloride599.4EGFR, ERBB4
25ag 490599.4EGFR, ERBB4
26ag 1478 hydrochloride599.4EGFR, ERBB4
27iressa599.4EGFR, ERBB4
28lisinopril44 11 2411.4AGTR1, VEGFA, ACE
29pd158780449.4EGFR, ERBB4
30perindopril44 49 1111.4ACE, VEGFA, AGTR1
31candesartan44 28 1111.4AGTR1, VEGFA, ACE
32carvedilol44 49 28 1112.4ACE, VEGFA, AGTR1
33pertuzumab44 49 1111.4EGFR, ERBB4
34hrgbeta1449.4EGFR, ERBB4
35everolimus49 44 1111.3EGFR, VEGFA
36chymostatin449.2ACE, AGTR1
37su5416449.2VEGFA, EGFR
38aldosterone28 11 2411.2AGTR1, EGFR
39capecitabine44 49 1111.1VEGFA, EGFR
40prostacyclin449.1ACE, VEGFA, AGTR1
41pd153035449.0ERBB4, VEGFA, EGFR
42cetuximab44 49 1110.9ERBB4, VEGFA, EGFR
43trastuzumab44 49 1110.9EGFR, VEGFA, ERBB4
44gefitinib44 49 1110.9EGFR, VEGFA, ERBB4
45ang ii448.6ACE, VEGFA, AGTR1, EGFR
46cisplatin44 49 59 1111.4EGFR, AGTR1, VEGFA, ERBB4
47genistein44 28 59 2 11 2413.1EGFR, AGTR1, VEGFA, NOTCH1, ERBB4
48vegf448.1EGFR, AGTR1, VEGFA, NOTCH1, ERBB4
49phosphatidylinositol448.1EGFR, AGTR1, NOTCH1, ERBB4
50tyrosine447.8EGFR, AGTR1, VEGFA, NOTCH1, ERBB4

GO Terms for genes affiliated with Left Ventricular Outflow Tract Obstruction

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16Gene Ontology
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Biological processes related to Left Ventricular Outflow Tract Obstruction according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1coronary vein morphogenesisGO:0031699.9NOTCH1, VEGFA
2positive regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:0614199.9VEGFA, NOTCH1
3cardiac vascular smooth muscle cell developmentGO:0609489.8VEGFA, NOTCH1
4coronary artery morphogenesisGO:0609829.8VEGFA, NOTCH1
5regulation of systemic arterial blood pressure by renin-angiotensinGO:0030819.8AGTR1, ACE
6tube formationGO:0351489.8NOTCH1, VEGFA
7regulation of vasodilationGO:0423129.7ACE, AGTR1
8cellular response to vascular endothelial growth factor stimulusGO:0359249.7VEGFA, NOTCH1
9regulation of vasoconstrictionGO:0192299.6AGTR1, ACE
10mammary gland alveolus developmentGO:0607499.5ERBB4, VEGFA
11positive regulation of cardiac muscle cell proliferationGO:0600459.4ERBB4, NOTCH1
12branching morphogenesis of an epithelial tubeGO:0487549.4VEGFA, NOTCH1
13kidney developmentGO:0018229.3ACE, VEGFA, AGTR1
14positive regulation of MAP kinase activityGO:0434069.1VEGFA, EGFR
15positive regulation of epithelial cell proliferationGO:0506799.0NOTCH1, VEGFA, EGFR
16lactationGO:0075959.0ERBB4, VEGFA
17positive regulation of cell migrationGO:0303358.9EGFR, VEGFA, NOTCH1
18positive regulation of protein phosphorylationGO:0019348.8ERBB4, VEGFA, EGFR
19positive regulation of cell proliferationGO:0082848.3EGFR, VEGFA, NOTCH1, ERBB4

Molecular functions related to Left Ventricular Outflow Tract Obstruction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1bradykinin receptor bindingGO:0317119.6ACE, AGTR1
2receptor signaling protein tyrosine kinase activityGO:0047169.0ERBB4, EGFR
3transmembrane receptor protein tyrosine kinase activityGO:0047148.9ERBB4, EGFR
4protein heterodimerization activityGO:0469828.4EGFR, AGTR1, VEGFA
5protein bindingGO:0055157.1ERBB4, ACE, NOTCH1, VEGFA, AGTR1, EGFR

Products for genes affiliated with Left Ventricular Outflow Tract Obstruction

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Sources for Left Ventricular Outflow Tract Obstruction

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet