MCID: LFT009
MIFTS: 50

Left Ventricular Outflow Tract Obstruction malady

Genetic diseases (common) category
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Summaries for Left Ventricular Outflow Tract Obstruction

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MalaCards based summary: Left Ventricular Outflow Tract Obstruction is related to hypertensive heart disease and hypertension. An important gene associated with Left Ventricular Outflow Tract Obstruction is NOTCH1 (notch 1), and among its related pathways are Heart Development and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The compounds temocaprilat and aliskiren have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and lung, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Aliases & Classifications for Left Ventricular Outflow Tract Obstruction

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Left Ventricular Outflow Tract Obstruction, Aliases & Descriptions:

Name: Left Ventricular Outflow Tract Obstruction 20 22


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)


Related Diseases for Left Ventricular Outflow Tract Obstruction

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Diseases related to Left Ventricular Outflow Tract Obstruction via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 81)
idRelated DiseaseScoreTop Affiliating Genes
1hypertensive heart disease31.2AGTR1, ACE
2hypertension30.9ACE, NOTCH1, AGTR1
3adenocarcinoma29.7VEGFA, ERBB4, NOTCH1, EGFR, AGTR1
4hypertrophic cardiomyopathy11.2
5transposition of the great arteries11.2
6ventricular septal defect11.1
7myocardial infarction11.0
8accessory mitral valve tissue11.0
9acute myocardial infarction10.9
10cardiogenic shock10.9
11atrioventricular septal defect10.8
12double outlet right ventricle10.7
13aneurysm10.7
14syncope10.7
15amyloidosis10.6
16ischemia10.6
17pheochromocytoma10.6
18mitral valve prolapse10.6
19atrioventricular block10.6
20hemolytic anemia10.4
21hypoplastic left heart syndrome10.4
22lung adenocarcinoma10.4
23renal cell carcinoma10.4
24diastolic heart failure10.4
25fabry disease10.4
26mitral valve stenosis10.4
27tricuspid valve prolapse10.4
28inferior myocardial infarction10.4
29cerebritis10.4
30aortic aneurysm10.4
31aortic valve stenosis10.4
32hemiplegia10.4
33liposarcoma10.4
34pericardial effusion10.4
35subvalvular aortic stenosis10.4
36pulmonary atresia with intact ventricular septum10.4
37stress cardiomyopathy10.4
38thromboembolism10.4
39dissecting aortic aneurysm10.4
40tunnel subaortic stenosis10.4
41renal tubular dysgenesis10.3ACE, AGTR1
42renovascular hypertension10.3ACE, AGTR1
43nephrosclerosis10.3ACE, AGTR1
44hyperaldosteronism10.3ACE, AGTR1
45erythrocytosis10.3AGTR1, ACE
46focal segmental glomerulosclerosis10.3AGTR1, ACE
47cerebrovascular disease10.2AGTR1, ACE
48glomerulosclerosis10.2ACE, AGTR1
49berger disease10.2AGTR1, ACE
50cork-handlers' disease10.2EGFR, ACE

Graphical network of the top 20 diseases related to Left Ventricular Outflow Tract Obstruction:



Diseases related to left ventricular outflow tract obstruction

Symptoms for Left Ventricular Outflow Tract Obstruction

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Drugs & Therapeutics for Left Ventricular Outflow Tract Obstruction

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Drug clinical trials:

Search ClinicalTrials for Left Ventricular Outflow Tract Obstruction

Search NIH Clinical Center for Left Ventricular Outflow Tract Obstruction

Genetic Tests for Left Ventricular Outflow Tract Obstruction

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Genetic tests related to Left Ventricular Outflow Tract Obstruction:

id Genetic test Affiliating Genes
1 Left Ventricular Outflow Tract Obstruction (lvoto)20 22 NOTCH1

Anatomical Context for Left Ventricular Outflow Tract Obstruction

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MalaCards organs/tissues related to Left Ventricular Outflow Tract Obstruction:

32
Heart, Liver, Lung, Testes

Animal Models for Left Ventricular Outflow Tract Obstruction or affiliated genes

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Publications for Left Ventricular Outflow Tract Obstruction

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Articles related to Left Ventricular Outflow Tract Obstruction:

(show top 50)    (show all 414)
idTitleAuthorsYear
1
Hybrid Stage I Palliation in a 1.1 kg, 28-Week Preterm Neonate With Posterior Malalignment Ventricular Septal Defect, Left Ventricular Outflow Tract Obstruction, and Coarctation of the Aorta. (25324263)
2014
2
Robot-assisted septal myectomy for hypertrophic cardiomyopathy with left ventricular outflow tract obstruction. (24793596)
2014
3
Impact of incidental amyloidosis on the prognosis of patients with hypertrophic cardiomyopathy undergoing septal myectomy for left ventricular outflow tract obstruction. (25217455)
2014
4
Relation between left ventricular outflow tract obstruction and left ventricular shape in patients with hypertrophic cardiomyopathy: a cardiac magnetic resonance imaging study. (23906680)
2013
5
Predictors of long-term outcomes in symptomatic hypertrophic obstructive cardiomyopathy patients undergoing surgical relief of left ventricular outflow tract obstruction. (23770748)
2013
6
The role of alcohol septal ablation in the treatment of left ventricular outflow tract obstruction in hypertrophic cardiomyopathy. (22093511)
2011
7
Exercise-induced left ventricular outflow tract obstruction in symptomatic patients with Anderson-Fabry disease. (21700093)
2011
8
Cardiogenic shock due to dynamic left ventricular outflow tract obstruction in acute myocardial infarction. (21452037)
2011
9
Modified Nikaidoh procedure in a patient with transposition of the great arteries, ventricular septal defect, and left ventricular outflow tract obstruction with unusual coronary anatomy. (21729497)
2011
10
Haemodynamic effects of acute intravenous metoprolol in apical ballooning syndrome with dynamic left ventricular outflow tract obstruction. (20097684)
2010
11
Surgical management of left ventricular outflow tract obstruction after biventricular repair of double outlet right ventricle. (20191035)
2010
12
Left ventricular outflow tract obstruction after the modified single patch repair of atrioventricular septal defects: teasing fact from fiction. (20338382)
2010
13
Mutations in VEGFA are associated with congenital left ventricular outflow tract obstruction. (20420808)
2010
14
The optimal procedure for the great arteries and left ventricular outflow tract obstruction. An anatomical study. (17353131)
2007
15
Left ventricular rhabdomyoma with severe left ventricular outflow tract obstruction: development of delayed hemiplegia after cardiopulmonary bypass. (17803580)
2007
16
Takotsubo cardiomyopathy with left ventricular outflow tract obstruction. (16337511)
2006
17
Different effects of propranolol, phenylephrine, and saline volume loading on catecholamine-induced left ventricular outflow tract obstruction in acute coronary syndrome. (16607055)
2006
18
Left ventricular outflow tract obstruction and sudden death risk in patients with hypertrophic cardiomyopathy. (16754630)
2006
19
Long-term results of apical aortic conduits in children with complex left ventricular outflow tract obstruction. (16305893)
2005
20
Multiple causes of left ventricular outflow tract obstruction in a 58-year-old woman. (15901301)
2005
21
Catecholamine therapy inducing dynamic left ventricular outflow tract obstruction. (15882688)
2005
22
Repair of transposition of the great arteries, ventricular septal defect and left ventricular outflow tract obstruction. (15082275)
2004
23
Patients with mild hypertensive heart disease and left ventricular outflow tract obstruction: treatment with angiotensin II antagonists. (15372301)
2004
24
Inferior myocardial infarction and shock associated with left ventricular outflow tract obstruction. (15322669)
2004
25
Effect of left ventricular outflow tract obstruction on clinical outcome in hypertrophic cardiomyopathy. (12540642)
2003
26
Echocardiographic diagnosis of left ventricular outflow tract obstruction after mitral valve replacement with subvalvular preservation. (12414054)
2002
27
Hypovolemia-induced reversible severe mitral regurgitation due to left ventricular outflow tract obstruction. (12487637)
2002
28
Comparison of left ventricular outflow tract obstruction in interruption of the aortic arch and in coarctation of the aorta, with diagnostic, developmental, and surgical implications. (11024401)
2000
29
Critical left ventricular outflow tract obstruction due to accessory mitral valve tissue. (10978978)
2000
30
Potential mechanism of left ventricular outflow tract obstruction after mitral ring annuloplasty. (10047649)
1999
31
Echocardiographic predictors of left ventricular outflow tract obstruction and systolic anterior motion of the mitral valve after mitral valve reconstruction for myxomatous valve disease. (10588230)
1999
32
Dynamic left ventricular outflow tract obstruction as a potential mechanism of myocardial rupture after acute myocardial infarction. (10588241)
1999
33
Echocardiographic diagnosis of left ventricular outflow tract obstruction caused by an acquired subaortic membrane after mitral valve replacement. (10231618)
1999
34
Patch repair of subsemilunar conal septal defect resulting in severe left ventricular outflow tract obstruction. (9359571)
1997
35
Influence of right ventricular pacing site on left ventricular outflow tract obstruction in patients with hypertrophic obstructive cardiomyopathy. (8609346)
1996
36
Left ventricular outflow tract obstruction as a cause for hypotension and symptoms during dobutamine stress echocardiography. (8674261)
1996
37
Repair of complex left ventricular outflow tract obstruction with a pulmonary autograft. (7582142)
1995
38
Relief of complex left ventricular outflow tract obstruction with pulmonary autografts. (7739236)
1995
39
Reduction of the left-ventricular outflow-tract obstruction by aortoventriculoplasty--long-term results of 96 patients. (8211925)
1993
40
Increased left ventricular outflow tract obstruction during exercise in patients with hypertrophic cardiomyopathy. (8426026)
1993
41
Left ventricular outflow tract obstruction with aortic arch anomalies and ventricular septal defect. (2241361)
1990
42
Accessory mitral valve leaflet causing aortic regurgitation and left ventricular outflow tract obstruction. Case report and review of published reports. (3285879)
1988
43
Noninvasive diagnosis of left ventricular outflow tract obstruction caused by a porcine mitral prosthesis. (3819212)
1987
44
Double outlet right ventricle with severe left ventricular outflow tract obstruction due to small ventricular septal defect and anomalous adherence of the mitral valve to the ventricular septum. (3437510)
1987
45
Left ventricular outflow tract obstruction with mitral valve replacement in small ventricular cavities. (3942435)
1986
46
Dynamic left ventricular outflow tract obstruction associated with pheochromocytoma. (7196146)
1981
47
The spectrum of left ventricular outflow tract obstruction: an overview. (7006467)
1980
48
Aortoventriculoplasty: a new technique for the treatment of left ventricular outflow tract obstruction. (131885)
1976
49
Parachute accessory anterior mitral valve leaflet causing left ventricular outflow tract obstruction. Report of a case with emphasis on the echocardiographic findings. (944108)
1976
50
Roentgenographic aspects of congenital left ventricular outflow tract obstruction. (5844924)
1965

Variations for Left Ventricular Outflow Tract Obstruction

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Expression for genes affiliated with Left Ventricular Outflow Tract Obstruction

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Expression patterns in normal tissues for genes affiliated with Left Ventricular Outflow Tract Obstruction

Search GEO for disease gene expression data for Left Ventricular Outflow Tract Obstruction.

Pathways for genes affiliated with Left Ventricular Outflow Tract Obstruction

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Pathways related to Left Ventricular Outflow Tract Obstruction according to GeneCards/GeneDecks:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5NOTCH1, VEGFA
2
Show member pathways
9.5AGTR1, ACE
39.4EGFR, NOTCH1
4
Show member pathways
Delta-Notch Signaling Pathway37
Notch Signaling Pathway37
9.4EGFR, NOTCH1
59.4AGTR1, EGFR
69.3VEGFA, EGFR
7
Show member pathways
9.3VEGFA, EGFR
89.3VEGFA, EGFR
9
Show member pathways
Development Ligand dependent activation of the ESR1 AP 1 pathway60
9.3VEGFA, EGFR
10
Show member pathways
9.3EGFR, VEGFA
11
Show member pathways
9.0EGFR, ERBB4
12
Show member pathways
9.0EGFR, ERBB4
139.0EGFR, ERBB4
14
Show member pathways
ErbB receptor signaling network37
ErbB signaling pathway37
9.0EGFR, ERBB4
15
Show member pathways
9.0EGFR, ERBB4
169.0EGFR, ERBB4
179.0EGFR, ERBB4
189.0EGFR, ERBB4
198.9VEGFA, NOTCH1, EGFR
20
Show member pathways
8.9AGTR1, EGFR, ACE
21
Show member pathways
8.6ERBB4, NOTCH1, EGFR
22
Show member pathways
8.6ERBB4, EGFR, AGTR1
238.6AGTR1, EGFR, ERBB4
24
Show member pathways
8.5EGFR, ERBB4, VEGFA
258.5VEGFA, ERBB4, EGFR
26
Show member pathways
7.6AGTR1, EGFR, NOTCH1, ERBB4, VEGFA

Compounds for genes affiliated with Left Ventricular Outflow Tract Obstruction

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Compounds related to Left Ventricular Outflow Tract Obstruction according to GeneCards/GeneDecks:

(show top 50)    (show all 111)
idCompoundScoreTop Affiliating Genes
1temocaprilat449.9AGTR1, ACE
2aliskiren44 1110.9ACE, AGTR1
3lacidipine449.9AGTR1, ACE
4mithramycin449.9EGFR
5angiotensin ii28 2410.8ACE, AGTR1
6saralasin449.8ACE, AGTR1
7eprosartan44 28 1111.8AGTR1, ACE
8trandolapril44 1110.8AGTR1, ACE
9pd12331944 2810.8ACE, AGTR1
10cilazapril44 1110.8AGTR1, ACE
11bradykinin61 28 2411.8ACE, AGTR1
12olmesartan44 28 1111.7ACE, AGTR1
13fosinopril44 1110.7ACE, AGTR1
14eplerenone44 61 28 1112.7AGTR1, ACE
15ptk787449.7EGFR, VEGFA
16panitumumab44 50 1111.7VEGFA, EGFR
17zd6474449.7EGFR, VEGFA
18benazepril44 50 1111.6ACE, AGTR1
19quinapril44 50 1111.5AGTR1, ACE
20vandetanib50 1110.5VEGFA, EGFR
21epiregulin289.5ERBB4, EGFR
22betacellulin289.5ERBB4, EGFR
23hb-egf289.4ERBB4, EGFR
24pd158780449.4EGFR, ERBB4
25lisinopril44 50 24 1112.4AGTR1, ACE, VEGFA
26ag 490619.4ERBB4, EGFR
27ag 1478 hydrochloride619.4ERBB4, EGFR
28perindopril44 50 1111.4AGTR1, ACE, VEGFA
29candesartan44 50 28 1112.4AGTR1, ACE, VEGFA
30jnj 28871063 hydrochloride619.4ERBB4, EGFR
31carvedilol44 50 28 1112.4VEGFA, AGTR1, ACE
32iressa619.4EGFR, ERBB4
33pertuzumab44 50 1111.4ERBB4, EGFR
34hrgbeta1449.4EGFR, ERBB4
35suramin44 28 1111.2AGTR1, EGFR, VEGFA
36su5416449.2VEGFA, EGFR
37prostacyclin449.2VEGFA, ACE, AGTR1
38capecitabine44 50 1111.0VEGFA, EGFR
39pd153035449.0ERBB4, EGFR, VEGFA
40cetuximab44 50 1110.9EGFR, ERBB4, VEGFA
41trastuzumab44 50 1110.9VEGFA, ERBB4, EGFR
42gefitinib44 50 1110.9ERBB4, EGFR, VEGFA
43ang ii448.8AGTR1, EGFR, ACE, VEGFA
44tamoxifen44 50 28 1111.5EGFR, ERBB4, VEGFA, AGTR1
45cisplatin44 50 61 1111.5AGTR1, ERBB4, VEGFA, EGFR
46phosphatidylinositol448.2ERBB4, NOTCH1, EGFR, AGTR1
47genistein44 28 61 2 24 1113.1AGTR1, NOTCH1, ERBB4, VEGFA, EGFR
48vegf448.1AGTR1, ERBB4, EGFR, VEGFA, NOTCH1
49estrogen448.1ERBB4, NOTCH1, EGFR, AGTR1, VEGFA
50tyrosine447.9EGFR, NOTCH1, ERBB4, VEGFA, AGTR1

GO Terms for genes affiliated with Left Ventricular Outflow Tract Obstruction

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Cellular components related to Left Ventricular Outflow Tract Obstruction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099868.9EGFR, NOTCH1, VEGFA
2receptor complexGO:0432358.7EGFR, NOTCH1, ERBB4
3extracellular regionGO:0055768.1VEGFA, ACE, ERBB4, NOTCH1
4integral component of membraneGO:0160217.6AGTR1, EGFR, NOTCH1, ERBB4, ACE
5plasma membraneGO:0058867.3ACE, ERBB4, NOTCH1, EGFR, AGTR1

Biological processes related to Left Ventricular Outflow Tract Obstruction according to GeneCards/GeneDecks:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1coronary vein morphogenesisGO:0031699.9NOTCH1, VEGFA
2positive regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:0614199.9VEGFA, NOTCH1
3cardiac vascular smooth muscle cell developmentGO:0609489.9VEGFA, NOTCH1
4coronary artery morphogenesisGO:0609829.9VEGFA, NOTCH1
5tube formationGO:0351489.8NOTCH1, VEGFA
6regulation of systemic arterial blood pressure by renin-angiotensinGO:0030819.8AGTR1, ACE
7regulation of vasodilationGO:0423129.8AGTR1, ACE
8cellular response to vascular endothelial growth factor stimulusGO:0359249.8VEGFA, NOTCH1
9regulation of vasoconstrictionGO:0192299.8AGTR1, ACE
10branching morphogenesis of an epithelial tubeGO:0487549.7NOTCH1, VEGFA
11positive regulation of inflammatory responseGO:0507299.5AGTR1, EGFR
12positive regulation of cardiac muscle cell proliferationGO:0600459.5ERBB4, NOTCH1
13positive regulation of MAP kinase activityGO:0434069.5VEGFA, EGFR
14liver developmentGO:0018899.4NOTCH1, EGFR
15mammary gland alveolus developmentGO:0607499.4ERBB4, VEGFA
16lactationGO:0075959.3ERBB4, VEGFA
17kidney developmentGO:0018229.3VEGFA, ACE, AGTR1
18positive regulation of epithelial cell proliferationGO:0506799.3EGFR, NOTCH1, VEGFA
19lung developmentGO:0303249.3EGFR, NOTCH1, VEGFA
20positive regulation of cell migrationGO:0303359.2VEGFA, NOTCH1, EGFR
21peptidyl-tyrosine phosphorylationGO:0181088.9EGFR, ERBB4
22positive regulation of transcription from RNA polymerase II promoterGO:0459448.9EGFR, NOTCH1, VEGFA
23positive regulation of protein phosphorylationGO:0019348.8EGFR, ERBB4, VEGFA
24positive regulation of ERK1 and ERK2 cascadeGO:0703748.7EGFR, ERBB4
25negative regulation of apoptotic processGO:0430668.6EGFR, ERBB4, VEGFA
26positive regulation of cell proliferationGO:0082848.4VEGFA, ERBB4, NOTCH1, EGFR

Molecular functions related to Left Ventricular Outflow Tract Obstruction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1bradykinin receptor bindingGO:0317119.6AGTR1, ACE
2receptor signaling protein tyrosine kinase activityGO:0047169.1EGFR, ERBB4
3protein tyrosine kinase activityGO:0047139.0EGFR, ERBB4
4transmembrane receptor protein tyrosine kinase activityGO:0047148.9EGFR, ERBB4
5protein heterodimerization activityGO:0469828.6VEGFA, EGFR, AGTR1
6protein bindingGO:0055157.1VEGFA, ACE, ERBB4, NOTCH1, EGFR, AGTR1

Products for genes affiliated with Left Ventricular Outflow Tract Obstruction

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Sources for Left Ventricular Outflow Tract Obstruction

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet