MCID: LGG001
MIFTS: 52

Legg-Calve-Perthes Disease malady

Genetic diseases, Rare diseases, Bone diseases categories

Aliases & Classifications for Legg-Calve-Perthes Disease

About this section
Sources:
49OMIM, 10Disease Ontology, 11diseasecard, 45NIH Rare Diseases, 12DISEASES, 65UMLS, 36MeSH, 67UniProtKB/Swiss-Prot, 24GTR, 23Genetics Home Reference, 47Novoseek, 51Orphanet, 59SNOMED-CT, 42NCIt, 28ICD10 via Orphanet, 66UMLS via Orphanet, 27ICD10, 34MedGen
See all sources

Aliases & Descriptions for Legg-Calve-Perthes Disease:

Name: Legg-Calve-Perthes Disease 49 10 11 45 12 65 36 67
Perthes Disease 10 45 23 47 51 67
Coxa Plana 10 45 24
Lcpd 45 23 67
Legg-Calvé-Perthes Disease 23 51
Avascular Necrosis of the Capital Femoral Epiphysis 65
Aseptic Necrosis of the Capital Femoral Epiphysis 51
Osteochondrosis of the Capital Femoral Epiphysis 51
Osteochondritis of the Capital Femoral Epiphysis 51
Juvenile Osteochondrosis of Hip and/or Pelvis 10
 
Juvenile Osteochondrosis of Hip and Pelvis 10
Osteochondrosis of Legg-Calve-Perthes 10
Juvenile Osteochond-Hip/pelvis 10
Legg-Calve-Perthes Syndrome 45
Osteochondritis Deformans 45
Calve - Perthes' Disease 10
Calve-Perthes Disease 23
Legg-Perthes Disease 67
Perthe's Disease 10
Pseudocoxalgia 10


Classifications:

Orphanet: 51 
Rare bone diseases


Characteristics (Orphanet epidemiological data):

51
perthes disease:
Inheritance: Autosomal dominant,Multigenic/multifactorial; Age of onset: Childhood; Age of death: normal life expectancy


External Ids:

OMIM49 150600
Disease Ontology10 DOID:14415
MeSH36 D007873
NCIt42 C34766
Orphanet51 2380
ICD10 via Orphanet28 M91.1
UMLS via Orphanet66 C0023234
ICD1027 M91, M91.2, M91.3
MedGen34 C0023234

Summaries for Legg-Calve-Perthes Disease

About this section
NIH Rare Diseases:45 Legg-calve-perthes disease occurs when the ball of the thighbone in the hip doesn’t get enough blood, causing the bone to die. early symptoms may include mildly painful limp, pain down the inner thigh to the knee, some restriction of hip movement, pain at extremes of movement, and tenderness over the hip joint. treatment may include a brief period of bed rest (1 to 3 days) followed by bracing. rarely bracing may be required for 2 to 3 years. chance of recovery (prognosis) varies, but tends to be better for younger patients (e.g., less than 6 years of age). some people with this syndrome go on to develop degenerative arthritis. the cause of the condition is unknown. last updated: 1/6/2011

MalaCards based summary: Legg-Calve-Perthes Disease, also known as perthes disease, is related to arthritis and protein c deficiency, and has symptoms including abnormality of the teeth, delayed skeletal maturation and arthralgia. An important gene associated with Legg-Calve-Perthes Disease is COL2A1 (Collagen, Type II, Alpha 1), and among its related pathways are Cell adhesion_ECM remodeling and Collagen biosynthesis and modifying enzymes. Affiliated tissues include hip joint, bone and skeletal muscle, and related mouse phenotypes are liver/biliary system and cardiovascular system.

Disease Ontology:10 An osteochondrosis that results in death and fracture located in hip joint.

Genetics Home Reference:23 Legg-Calvé-Perthes disease is a bone disorder that affects the hips. Usually, only one hip is involved, but in about 10 percent of cases, both hips are affected. Legg-Calvé-Perthes disease begins in childhood, typically between ages 4 and 8, and affects boys more frequently than girls.

OMIM:49 Legg-Calve-Perthes disease is characterized by loss of circulation to the femoral head, resulting in avascular necrosis... (150600) more...

UniProtKB/Swiss-Prot:67 Legg-Calve-Perthes disease: Characterized by loss of circulation to the femoral head, resulting in avascular necrosis in a growing child. Clinical pictures of the disease vary, depending on the phase of disease progression through ischemia, revascularization, fracture and collapse, and repair and remodeling of the bone.

Related Diseases for Legg-Calve-Perthes Disease

About this section

Diseases related to Legg-Calve-Perthes Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 342)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis30.7APOH, SERPINE1
2protein c deficiency30.2APOH, F5, SERPINC1
3osteochondritis dissecans10.7
4avascular necrosis of the femoral head10.4
5osteochondrosis10.4
6exostosis10.4
7hypopituitarism10.4
8synovitis10.4
9thrombophilia10.4
10pandas10.4
11slipped capital femoral epiphysis10.4
12osteonecrosis10.4
13multiple epiphyseal dysplasia10.4
14secondary syphilis10.3
15bone structure disease10.3
16physical disorder10.3
17bolivian hemorrhagic fever10.2SERPINC1, SERPINE1
18abducens nerve neoplasm10.2SERPINC1, SERPINE1
19malignant otitis externa10.2SERPINC1, SERPINE1
20achondroplasia10.2
21osteoarthritis10.2
22pain disorder10.2
23thyroiditis10.2
24intracranial structure hemangioma10.2F5, SERPINC1
25azygos continuation of the inferior vena cava10.2F5, SERPINE1
26ehlers-danlos syndrome, type vi10.2
27schwartz-jampel syndrome, type 110.2
28thrombocytopenia-absent radius syndrome10.2
29chromosome 1q21.1 duplication syndrome10.2
30prune belly syndrome10.2
31epiphyseal dysplasia, multiple, 510.2
32ehlers-danlos syndrome, type iv10.2
33acrocapitofemoral dysplasia10.2
34orotic aciduria10.2
35spondylometaphyseal dysplasia with cone-rod dystrophy10.2
36thanatophoric dysplasia, type i10.2
37mucopolysaccharidosis is10.2
38short syndrome10.2
39ehlers-danlos syndrome, type viic10.2
40marinesco-sjogren syndrome10.2
41diastrophic dysplasia10.2
42sotos syndrome 110.2
43larsen-like syndrome10.2
44yunis-varon syndrome10.2
45metaphyseal chondrodysplasia, schmid type10.2
46radioulnar synostosis with amegakaryocytic thrombocytopenia10.2
47mucopolysaccharidosis vii10.2
48coffin-siris syndrome10.2
49weaver syndrome10.2
50pfeiffer syndrome10.2

Graphical network of the top 20 diseases related to Legg-Calve-Perthes Disease:



Diseases related to legg-calve-perthes disease

Symptoms for Legg-Calve-Perthes Disease

About this section

Symptoms by clinical synopsis from OMIM:

150600

Clinical features from OMIM:

150600

Symptoms:

 51 (show all 9)
  • abnormal dentition/dental position/implantation/unerupted/dental ankylosis
  • muscle hypotrophy/atrophy/dystrophy/agenesis/amyotrophy
  • delayed bone age
  • osteonecrosis/bone infarction
  • articular/joint pain/arthralgia
  • joint/articular deformation
  • cartilage destruction/chondrolysis
  • polygenic/multifactorial inheritance
  • short stature/dwarfism/nanism

HPO human phenotypes related to Legg-Calve-Perthes Disease:

(show all 9)
id Description Frequency HPO Source Accession
1 abnormality of the teeth hallmark (90%) HP:0000164
2 delayed skeletal maturation hallmark (90%) HP:0002750
3 arthralgia hallmark (90%) HP:0002829
4 skeletal muscle atrophy hallmark (90%) HP:0003202
5 short stature hallmark (90%) HP:0004322
6 cartilage destruction hallmark (90%) HP:0100773
7 delayed skeletal maturation HP:0002750
8 short stature HP:0004322
9 avascular necrosis of the capital femoral epiphysis HP:0005743

Drugs & Therapeutics for Legg-Calve-Perthes Disease

About this section

Drugs for Legg-Calve-Perthes Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Triamcinoloneapproved429124-94-731307
Synonyms:
(8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
11-beta,16-alpha,17-alpha,21-Tetrahydroxy-9-alpha-fluoro-1,4-pregnadiene-3,20-dione
11.Beta.,16.alpha.,17.alpha., 21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione
11.beta.,16.alpha.,17.alpha.,21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione
11beta,16alpha,17alpha,21-Tetrahydroxy-9alpha-fluoro-1,4-pregnadiene-3,20-dione
124-94-7
4-08-00-03629 (Beilstein Handbook Reference)
83474-03-7
9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-alpha-Fluoro-11-beta,16-alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-alpha-Fluoro-16-alpha-hydroxyprednisolone
9.Alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahy
9.Alpha.-Fluoro-11.beta.,16.alpha.,17.alpha., 21-tetrahydroxypregna-1,4-diene-3,20-d
9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione
9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9.alpha.-Fluoro-11.beta.,16.alpha.,17.alpha.,21-tetrahydroxypregna-1,4-diene-3,20-dione
9.alpha.-Fluoro-16.alpha.-hydroxyprednisolone
9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione
9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9alpha-Fluoro-11beta,16alpha,17alpha,21-tetrahydroxypregna-1,4-diene-3,20-dione
9alpha-Fluoro-16alpha-hydroxyprednisolone
9α-fluoro-16α-hydroxyprednisolone
AC-2072
AC1L1LDH
AC1Q5HJC
Adcortyl
Allernaze
Aristocort
Aristocort A
Aristocort Tablets
Aristogel
Aristospan
Azmacort
BPBio1_000154
BRD-K77554836-001-03-3
BRN 2341955
BSPBio_000140
Bio-0662
C21H27FO6
CHEMBL1451
CID31307
CL 19823
Celeste
Cinolone
Cinolone-T
D00385
D014221
DB00620
Delphicort
EINECS 204-718-7
EU-0101179
Fluoxiprednisolone
Fluoxyprednisolone
Flutex
Fougera
HMS1568G22
HMS2090D12
HSDB 3194
Kenacort
Kenacort (TN)
Kenacort-A
Kenacort-AG
Kenacort-Ag
Kenalog
Kenalog in Orabase
Kenalog-10
Kenalog-40
Kenalog-H
LS-698
Ledercort
Lopac0_001179
MLS000028542
MLS001066543
 
MLS002695935
MolPort-002-528-981
Mycolog
NCGC00021580-03
NCGC00021580-04
NCGC00021580-05
NCGC00021580-06
NCGC00021580-07
NCI60_000750
NSC 13397
NSC13397
Nasacort
Nasacort Aq
Nasacort Hfa
Omcilon
Omicilon
Oracort
Oralone
Orion
Polcortolon
Pregna-1,4-diene-3,20-dio
Pregna-1,4-diene-3,20-dione, 9-fluoro-11,16,17,21-tetrahydroxy-, (11beta,16alpha)
Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,16alpha,17,21-tetrahydroxy- (8CI)
Prestwick0_000120
Prestwick1_000120
Prestwick2_000120
Prestwick3_000120
Prestwick_438
Rodinolone
S1933_Selleck
SK-Triamcinolone
SMP1_000300
SMR000058333
SPBio_002079
Sk-Triamcinolone
T6376_SIGMA
TRIAMCINOLONE (SEE ALSO TRIAMCINOLONE ACETONIDE (76-25-5) AND TRIAMCINOLONE DIACETATE (67-78-7))
Tiamcinolonum
Tiamcinolonum [INN-Latin]
Tri-Nasal
Triacet
Triacort
Triam-Tablinen
Triamcet
Triamcinalone
Triamcinlon
Triamcinolon
Triamcinolona
Triamcinolona [INN-Spanish]
Triamcinolone (JP15/USP/INN)
Triamcinolone Acetonide
Triamcinolone [USAN:INN:BAN:JAN]
Triamcinolone acetonide
Triamcinolone diacetate
Triamcinolone hexacetonide
Triamcinolonum
Triamcinolonum [INN]
Trianex
Triatex
Tricortale
Triderm
Triesence
Trilone
Tristoject
Trymex
UNII-1ZK20VI6TY
Vetalog
Volon
Volon A
WLN: L E5 B666 OV KU MUTJ A1 BF CQ E1 FV1Q FQ GQ
ZINC03882036
droxypregna-1,4-diene-3,20-dione
ione
nchembio.2007.53-comp7
triamcinolone
2
Vitamin Eapproved, nutraceutical35059-02-914985
Synonyms:
(+)-a-Tocopherol
(+)-alpha-Tocopherol
(+)-alpha-tocopherol
(+)-α-tocopherol
(2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-trimethyltridecyl]chroman-6-ol
(2R)-3,4-Dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-ol
(2R,4'R,8'R)-a-Tocopherol
(2R,4'R,8'R)-alpha-Tocopherol
(2R,4'R,8'r)-alpha-tocopherol
(R,R,R)-a-Tocopherol
(R,R,R)-alpha-Tocopherol
(R,R,R)-alpha-tocopherol
(R,R,R)-α-tocopherol
5,7,8-Trimethyltocol
Amino-Opti-E
Aquasol E
D-alpha-Tocopherol
Daltose
Denamone
E-200 I.U. Softgels
 
E-Complex-600
E-Ferol
E-Vitamin succinate
Eprolin
Gordo-Vite E
Phytogermin
Phytogermine
RRR-alpha-tocopherol
RRR-alpha-tocopheryl
Tocopherol
Vitamin E
Vitamin Ea
Vitamin Plus E Softgells
Vitamin e
Vitec
a-D-Tocopherol
a-Tocopherol
alpha-Tocopherol
alpha-delta-Tocopherol
d-alpha-tocopherol
d-α-tocopherol
delta-alpha-Tocopherol
3Tocotrienols352
4Tocopherols355
5Gadolinium DTPA82
6Gadobenic acid82
7Triamcinolone hexacetonide429
8Triamcinolone diacetate429
9triamcinolone acetonide429
10TocotrienolNutraceutical352
11TocopherolNutraceutical355

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Randomised Multi-centre Study to Compare the Long-term Performance of the Future Hip to 3 Other Implants in Primary Total Hip ReplacementTerminatedNCT00208468Phase 3
2The Long Term Outcome of Varus Derotational Osteotomy for Legg-Calvé-Perthes' DiseaseCompletedNCT02676271
3Diagnosis of Mucopolysaccharidosis Disorders in Patients Presenting With Bilateral Hip DiseaseCompletedNCT01707433
4Multicenter Prospective Cohort Study on Current Treatments of Legg-Calvé-Perthes DiseaseRecruitingNCT02040714
5Evaluate E1 Wear, Clinical Performance of E1 Liner in THA in Korean Patient PopulationRecruitingNCT02087449
6Taperloc Complete Microplasty vs Taperloc Complete Standard: Randomized Controlled Study on Bone Mineral DensityActive, not recruitingNCT02087436
7The Effect of Perthes' Disease on Hip CartilageSuspendedNCT00958464
8Intraarticular Corticosteroid Therapy in Perthes Disease.TerminatedNCT01026909

Search NIH Clinical Center for Legg-Calve-Perthes Disease


Cochrane evidence based reviews: Legg-Calve-Perthes Disease

Genetic Tests for Legg-Calve-Perthes Disease

About this section

Genetic tests related to Legg-Calve-Perthes Disease:

id Genetic test Affiliating Genes
1 Coxa Plana24

Anatomical Context for Legg-Calve-Perthes Disease

About this section

MalaCards organs/tissues related to Legg-Calve-Perthes Disease:

33
Bone, Skeletal muscle

FMA organs/tissues related to Legg-Calve-Perthes Disease:

16
Hip joint

Animal Models for Legg-Calve-Perthes Disease or affiliated genes

About this section

MGI Mouse Phenotypes related to Legg-Calve-Perthes Disease:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053707.5COL2A1, F5, SELE, SERPINC1, SERPINE1, THBD
2MP:00053857.1COL2A1, F5, SELE, SERPINC1, SERPINE1, THBD
3MP:00107686.9APOH, COL2A1, F5, SELE, SERPINC1, SERPINE1

Publications for Legg-Calve-Perthes Disease

About this section

Articles related to Legg-Calve-Perthes Disease:

(show top 50)    (show all 96)
idTitleAuthorsYear
1
Comparative study of serum proteomes in Legg-Calve-Perthes disease. (26438379)
2015
2
Treatment of Arthritis Associated With Legg-Calve-Perthes Disease With Modular Total Hip Arthroplasty. (25979188)
2015
3
TAPnnis triple pelvic osteotomy for Legg-Calve-Perthes disease. (25417791)
2015
4
Guided growth of the trochanteric apophysis combined with soft tissue release for Legg-Calve-Perthes disease. (24563149)
2014
5
Local delivery of recombinant human bone morphogenetic proteins and bisphosphonate via sucrose acetate isobutyrate can prevent femoral head collapse in Legg-Calve-Perthes disease: a pilot study in pigs. (24389948)
2014
6
"Femoroacetabular impingement". Legg-Calve-Perthes disease: from childhood to adulthood. (25217031)
2014
7
Increased soluble selectins as a reflection of activated platelets and endothelium in Legg-Calve-Perthes disease. (25000467)
2014
8
Management of Legg-Calve-Perthes disease with acupuncture: a case report. (23234840)
2013
9
Diffusion MRI of the neck of the femur in Legg-Calve-Perthes disease: a preliminary study. (23206418)
2013
10
Combined osteotomy in patients with severe Legg-Calve-Perthes disease. (23451451)
2012
11
Natural history of early onset and late-onset Legg-Calve-Perthes disease. (21857430)
2011
12
Serum prolidase activity and oxidative-antioxidative status in Legg-Calve-Perthes disease. (21304409)
2011
13
Femoral varus osteotomy in Legg-Calve-Perthes disease. (21857437)
2011
14
Legg-Calve-Perthes disease centenary. (21857425)
2011
15
Legg-Calve-Perthes disease in a patient with Albright hereditary osteodystrophy: a case report. (20124073)
2010
16
Legg-Calve-Perthes disease and risks for cardiovascular diseases and blood diseases. (20439602)
2010
17
Varus producing osteotomy for patients with lateral pillar type B and C Legg-Calve-Perthes disease followed to skeletal maturity. Castaneda et al. JCOR (2008), 2:373-379. (19308615)
2009
18
Triple pelvic osteotomy in the treatment of Legg-Calve-Perthes disease. (19301002)
2009
19
Coxa magna quantification using MRI in Legg-Calve-Perthes disease. (18992975)
2009
20
MRI of Legg-Calve-Perthes disease. (19843759)
2009
21
Thrombomodulin and GFC levels in Legg-Calve-Perthes disease. (19055859)
2008
22
Sagittal spinal alignment in patients with Legg-Calve-Perthes disease. (17875086)
2007
23
Interruption of the blood supply of femoral head: an experimental study on the pathogenesis of Legg-Calve-Perthes Disease. (17598118)
2007
24
Outcome of cheilectomy in Legg-Calve-Perthes disease: minimum 25-year follow-up of five patients. (16557136)
2006
25
Reliability of radiological classifications used in Legg-Calve-Perthes disease. (16751735)
2006
26
Protein C levels in patients with Legg-Calve-Perthes disease: is it a true deficiency? (16557135)
2006
27
Residual shortening after Legg-Calve-Perthes disease, focusing on the response of the ipsilateral tibia. (15832141)
2005
28
Automated analysis of MR image of hip: geometrical evaluation of the Legg-Calve-Perthes disease. (15863350)
2005
29
Enhanced tissue factor pathway inhibitor response as a defense mechanism against ongoing local microvascular events of Legg-Calve-Perthes disease. (16020129)
2005
30
Usefulness of epiphyseal quotient measurement on magnetic resonance images for outcome prediction in patients with early-stage Legg-Calve-Perthes disease. (15577302)
2005
31
Arthroscopic findings of the hip in new onset hip pain in adolescents with previous Legg-Calve-Perthes disease. (15812283)
2005
32
The correlation between coxa magna and final outcome in Legg-Calve-Perthes disease. (15614054)
2005
33
Legg-Calve-Perthes disease. Part I: Classification of radiographs with use of the modified lateral pillar and Stulberg classifications. (15466719)
2004
34
Legg-Calve-Perthes disease and thrombophilia. (15590848)
2004
35
Treatment of the collapsed femoral head by containment in Legg-Calve-Perthes disease. (12499936)
2003
36
Avascular necrosis of the femoral heads in a red panda (Ailurus fulgens fulgens): possible Legg-Calve-Perthes disease. (12462497)
2002
37
Hip arthroscopy in Legg-Calve-Perthes disease. (10024039)
1999
38
Legg-Calve-Perthes Disease: Imaging Evaluation and Management. (11388931)
1999
39
Legg-Calve-Perthes disease: clinical analysis of 57 cases. (1982536)
1990
40
Legg-Calve-Perthes disease associated with hereditary multiple exostosis: a case report. (306501)
1978
41
A study of the radiographic and histological changes occurring in Legg-Calve-Perthes disease (LCP) in the dog. (5531150)
1970
42
Minimal Legg-Calve-Perthes disease. (5241837)
1968
43
The results of treatment in Legg-Calve-Perthes disease using a Thomas splint. (4870483)
1967
44
Hereditary Legg-Calve-Perthes disease. (13998760)
1963
45
Experimental production in the rabbit of coxa plana: a lesion resembling Legg-Calve-Perthes disease in man. (13950195)
1963
46
Legg-Calve-Perthes disease: the roentgenologic changes with therapy in forty patients. (14486234)
1962
47
Inherited vascular pattern of the femoral head and neck as a predisposing factor to Legg-Calve-Perthes disease. (13932250)
1962
48
Osteochondritis dissecans following Legg-Calve-Perthes disease. A report of one case. (13849850)
1960
49
Legg-Calve-Perthes disease. (13807159)
1960
50
The deformity in Legg-Calve-Perthes disease. (13716060)
1960

Variations for Legg-Calve-Perthes Disease

About this section

Clinvar genetic disease variations for Legg-Calve-Perthes Disease:

5
id Gene Variation Type Significance SNP ID Assembly Location
1COL2A1NM_001844.4(COL2A1): c.3508G> A (p.Gly1170Ser)single nucleotide variantPathogenicrs121912891GRCh37Chr 12, 48369835: 48369835

Expression for genes affiliated with Legg-Calve-Perthes Disease

About this section
Search GEO for disease gene expression data for Legg-Calve-Perthes Disease.

Pathways for genes affiliated with Legg-Calve-Perthes Disease

About this section

GO Terms for genes affiliated with Legg-Calve-Perthes Disease

About this section

Cellular components related to Legg-Calve-Perthes Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:003109310.1F5, SERPINE1
2extracellular matrixGO:00310128.9APOH, COL2A1, SERPINE1
3extracellular spaceGO:00056156.9APOH, COL2A1, F5, SELE, SERPINC1, SERPINE1

Biological processes related to Legg-Calve-Perthes Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of blood coagulationGO:00301949.8APOH, SERPINE1
2negative regulation of fibrinolysisGO:00519189.3APOH, SERPINE1, THBD
3negative regulation of blood coagulationGO:00301959.2APOH, SERPINE1, THBD
4blood coagulationGO:00075967.3APOH, F5, SELE, SERPINC1, SERPINE1, THBD

Sources for Legg-Calve-Perthes Disease

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet