MCID: LGG001
MIFTS: 57

Legg-Calve-Perthes Disease malady

Categories: Genetic diseases, Rare diseases, Bone diseases

Aliases & Classifications for Legg-Calve-Perthes Disease

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Sources:
11Disease Ontology, 12diseasecard, 13DISEASES, 25Genetics Home Reference, 27GTR, 30ICD10, 31ICD10 via Orphanet, 37MedGen, 39MeSH, 45NCIt, 48NIH Rare Diseases, 50Novoseek, 52OMIM, 54Orphanet, 62SNOMED-CT, 68UMLS, 69UMLS via Orphanet, 70UniProtKB/Swiss-Prot
See all MalaCards sources

Aliases & Descriptions for Legg-Calve-Perthes Disease:

Name: Legg-Calve-Perthes Disease 52 11 48 70 12 39 13 68
Perthes Disease 11 48 25 54 70 50
Coxa Plana 11 48 27
Lcpd 48 25 70
Legg-Calvé-Perthes Disease 25 54
Avascular Necrosis of the Capital Femoral Epiphysis 68
Aseptic Necrosis of the Capital Femoral Epiphysis 54
Osteochondrosis of the Capital Femoral Epiphysis 54
Osteochondritis of the Capital Femoral Epiphysis 54
Juvenile Osteochondrosis of Hip and/or Pelvis 11
Juvenile Osteochondrosis of Hip and Pelvis 11
 
Osteochondrosis of Legg-Calve-Perthes 11
Juvenile Osteochond-Hip/pelvis 11
Legg-Calve-Perthes Syndrome 48
Legg-Calve-Perthes Symptom 11
Osteochondritis Deformans 48
Calve - Perthes' Disease 11
Calve-Perthes Disease 25
Legg-Perthes Disease 70
Perthe's Disease 11
Pseudocoxalgia 11

Characteristics:

Orphanet epidemiological data:

54
perthes disease:
Inheritance: Autosomal dominant,Multigenic/multifactorial; Age of onset: Childhood; Age of death: normal life expectancy

Classifications:



External Ids:

OMIM52 150600
Disease Ontology11 DOID:14415
ICD1030 M91.2, M91.3, M91
MeSH39 D007873
NCIt45 C34766
Orphanet54 ORPHA2380
UMLS via Orphanet69 C0023234
ICD10 via Orphanet31 M91.1
MedGen37 C0023234

Summaries for Legg-Calve-Perthes Disease

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NIH Rare Diseases:48 Legg-Calve-Perthes disease (LCPD) occurs when blood supply to the ball of the thighbone in the hip (femoral head) is disrupted. Without an adequate blood supply, the bone cells die. LCPD usually occurs in children between the ages of 4 and 10. Early symptoms may include limping; pain in the hip, thigh or knee; and reduced range of hip motion. Later in the disease course, there may be leg length discrepancy (one leg longer than the other) and wasting of the muscles around the hip. The condition can last for several years before new bone formation (re-ossification) and eventual healing occurs. Some people with LCPD go on to develop degenerative arthritis in adulthood. The underlying cause of LCPD is often not known. Sometimes it results from a slipped capital femoral epiphysis, trauma, steroid use, sickle-cell crisis, toxic synovitis, or congenital hip dysplasia. It usually is not caused by genetic factors, but a few familial cases with autosomal dominant inheritance have been reported. In a small percentage of cases, mutations in the COL2A1 gene were found to be responsible. Treatment aims to keep the thigh bone inside the hip socket. Treatment options may include rest or medication for pain; physical therapy; using a brace; or surgery. Last updated: 7/28/2016

MalaCards based summary: Legg-Calve-Perthes Disease, also known as perthes disease, is related to thrombophilia and garret tripp syndrome, and has symptoms including abnormality of the teeth, delayed skeletal maturation and arthralgia. An important gene associated with Legg-Calve-Perthes Disease is COL2A1 (Collagen Type II Alpha 1 Chain), and among its related pathways are Cell adhesion_ECM remodeling and T Cell Co-Signaling Pathway: Ligand-Receptor Interactions. Affiliated tissues include hip joint, bone and skeletal muscle, and related mouse phenotypes are embryo and liver/biliary system.

Disease Ontology:11 An osteochondrosis that results in death and fracture located in hip joint.

UniProtKB/Swiss-Prot:70 Legg-Calve-Perthes disease: Characterized by loss of circulation to the femoral head, resulting in avascular necrosis in a growing child. Clinical pictures of the disease vary, depending on the phase of disease progression through ischemia, revascularization, fracture and collapse, and repair and remodeling of the bone.

Genetics Home Reference:25 Legg-Calvé-Perthes disease is a bone disorder that affects the hips. Usually, only one hip is involved, but in about 10 percent of cases, both hips are affected. Legg-Calvé-Perthes disease begins in childhood, typically between ages 4 and 8, and affects boys more frequently than girls.

OMIM:52 Legg-Calve-Perthes disease is characterized by loss of circulation to the femoral head, resulting in avascular necrosis... (150600) more...

Related Diseases for Legg-Calve-Perthes Disease

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Diseases related to Legg-Calve-Perthes Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 114)
idRelated DiseaseScoreTop Affiliating Genes
1thrombophilia29.9APOH, F5, SERPINC1
2garret tripp syndrome10.9
3upington disease10.5
4lymphatic system cancer10.4SERPINC1, THBD
5venezuelan hemorrhagic fever10.4SERPINC1, SERPINE1
6hypertensive heart disease10.4SERPINC1, SERPINE1
7lateral cystocele10.4SERPINC1, SERPINE1
8osteochondritis dissecans10.4
9diphyllobothriasis10.3CD40LG, SERPINC1
10marek disease10.3CD40LG, SERPINC1
11laryngeal cartilage cancer10.3CD40LG, COL2A1
12thyroid hyalinizing trabecular adenoma10.3F5, SERPINC1
13fiedler's myocarditis10.3SERPINC1, THBD
14bone resorption disease10.3COL2A1, SERPINE1
15rocky mountain spotted fever10.3CD40LG, SERPINC1
16prostatic hypertrophy10.3CD40LG, SERPINC1
17lujo hemorrhagic fever10.3CD40LG, SERPINC1
18congenital stenosis of the inferior vena cava10.3F5, SERPINE1
19ameloblastic carcinoma10.2F5, SERPINE1
20lip carcinoma in situ10.2F5, SERPINC1
21chronic apical periodontitis10.2CD40LG, SERPINC1
22platelet storage pool deficiency10.2CD40LG, SERPINC1
23west nile fever10.2F5, SERPINE1
24retinal dystrophy, iris coloboma, and comedogenic acne syndrome10.2F5, SERPINE1
25bacteriuria10.2CD40LG, SERPINC1
26spinocerebellar ataxia 2710.2F5, SERPINC1
27ovarian insufficiency, familial10.1COL2A1, SERPINC1, SERPINE1
28calcifying epithelial odontogenic tumor10.1SELE, THBD
29casr-related disorders10.1SELE, SERPINE1
30avascular necrosis of the femoral head10.1
31arthritis10.1
32osteochondrosis10.1
33osteonecrosis10.1
34exostosis10.1
35synovitis10.1
36hypopituitarism10.1
37factor v leiden thrombophilia10.1
38kienbock's disease10.1
39pandas10.1
40parasitic helminthiasis infectious disease10.1CD40LG, SELE
41indian tick typhus10.1CD40LG, SELE
42tollner horst manzke syndrome10.1SERPINC1, SERPINE1, THBD
43microcytic anemia10.1SERPINC1, SERPINE1, THBD
44chromoblastomycosis10.0CD40LG, SELE
45angular blepharoconjunctivitis10.0F5, SERPINC1, THBD
46pseudohermaphroditism10.0F5, SERPINC1, THBD
47pes anserinus tendinitis or bursitis10.0CD40LG, SERPINC1, THBD
48leukostasis10.0CD40LG, SELE
49labyrinthine bilateral reactive loss10.0CD40LG, SELE
50frontal sinus cancer10.0F5, SERPINC1, THBD

Graphical network of the top 20 diseases related to Legg-Calve-Perthes Disease:



Diseases related to legg-calve-perthes disease

Symptoms & Phenotypes for Legg-Calve-Perthes Disease

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Symptoms by clinical synopsis from OMIM:

150600

Clinical features from OMIM:

150600

Human phenotypes related to Legg-Calve-Perthes Disease:

 64 54 (show all 9)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 abnormality of the teeth64 54 hallmark (90%) Very frequent (99-80%) HP:0000164
2 delayed skeletal maturation64 54 hallmark (90%) Very frequent (99-80%) HP:0002750
3 arthralgia64 54 hallmark (90%) Very frequent (99-80%) HP:0002829
4 skeletal muscle atrophy64 54 hallmark (90%) Very frequent (99-80%) HP:0003202
5 short stature64 54 hallmark (90%) Very frequent (99-80%) HP:0004322
6 cartilage destruction64 54 hallmark (90%) Very frequent (99-80%) HP:0100773
7 avascular necrosis of the capital femoral epiphysis64 HP:0005743
8 joint dislocation54 Very frequent (99-80%)
9 aseptic necrosis54 Very frequent (99-80%)

MGI Mouse Phenotypes related to Legg-Calve-Perthes Disease according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053809.3COL2A1, F5, PEPD, SERPINC1, THBD
2MP:00053708.4COL2A1, F5, SELE, SERPINC1, SERPINE1, THBD
3MP:00107718.1CD40LG, F5, PEPD, SELE, SERPINE1, THBD
4MP:00053677.9CD40LG, COL2A1, PEPD, SERPINC1, SERPINE1, THBD
5MP:00053857.4CD40LG, COL2A1, F5, PEPD, SELE, SERPINC1
6MP:00053766.9APOH, CD40LG, COL2A1, F5, PEPD, SELE
7MP:00107686.8APOH, CD40LG, COL2A1, F5, PEPD, SELE

Drugs & Therapeutics for Legg-Calve-Perthes Disease

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Drugs for Legg-Calve-Perthes Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Triamcinoloneapproved, vet_approved482124-94-731307
Synonyms:
(8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
11-beta,16-alpha,17-alpha,21-Tetrahydroxy-9-alpha-fluoro-1,4-pregnadiene-3,20-dione
11.Beta.,16.alpha.,17.alpha., 21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione
11.beta.,16.alpha.,17.alpha.,21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione
11β,16α,17α,21-tetrahydroxy-9α-fluoro-1,4-pregnadiene-3,20-dione
124-94-7
4-08-00-03629 (Beilstein Handbook Reference)
83474-03-7
9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-alpha-Fluoro-11-beta,16-alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-alpha-Fluoro-16-alpha-hydroxyprednisolone
9-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9.Alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahy
9.Alpha.-Fluoro-11.beta.,16.alpha.,17.alpha., 21-tetrahydroxypregna-1,4-diene-3,20-d
9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione
9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9.alpha.-Fluoro-11.beta.,16.alpha.,17.alpha.,21-tetrahydroxypregna-1,4-diene-3,20-dione
9.alpha.-Fluoro-16.alpha.-hydroxyprednisolone
9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione
9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9alpha-Fluoro-16alpha-hydroxyprednisolone
9α-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9α-fluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione
9α-fluoro-16α-hydroxyprednisolone
AC-2072
AC1L1LDH
AC1Q5HJC
Adcortyl
Aristocort
Aristocort A
Aristocort Tablets
Aristogel
Aristospan
Azmacort
BPBio1_000154
BRD-K77554836-001-03-3
BRN 2341955
BSPBio_000140
Bio-0662
C21H27FO6
CHEMBL1451
CID31307
CL 19823
Celeste
Cinolone
Cinolone-T
D00385
D014221
DB00620
Delphicort
EINECS 204-718-7
EU-0101179
Fluoxiprednisolone
Fluoxyprednisolone
Flutex
Fougera
HMS1568G22
HMS2090D12
HSDB 3194
Kenacort
Kenacort (TN)
Kenacort-A
Kenacort-AG
Kenacort-Ag
Kenalog
Kenalog in Orabase
Kenalog-10
Kenalog-40
Kenalog-H
LS-698
Ledercort
Lopac0_001179
 
MLS000028542
MLS001066543
MLS002695935
MolPort-002-528-981
Mycolog
NCGC00021580-03
NCGC00021580-04
NCGC00021580-05
NCGC00021580-06
NCGC00021580-07
NCI60_000750
NSC 13397
NSC13397
Nasacort
Nasacort Aq
Nasacort Hfa
Omcilon
Omicilon
Oracort
Oralone
Orion
Polcortolon
Pregna-1,4-diene-3,20-dio
Pregna-1,4-diene-3,20-dione, 9-fluoro-11,16,17,21-tetrahydroxy-, (11beta,16alpha)
Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,16alpha,17,21-tetrahydroxy- (8CI)
Prestwick0_000120
Prestwick1_000120
Prestwick2_000120
Prestwick3_000120
Prestwick_438
Rodinolone
S1933_Selleck
SK-Triamcinolone
SMP1_000300
SMR000058333
SPBio_002079
Sk-Triamcinolone
T6376_SIGMA
TRIAMCINOLONE (SEE ALSO TRIAMCINOLONE ACETONIDE (76-25-5) AND TRIAMCINOLONE DIACETATE (67-78-7))
Tiamcinolonum
Tiamcinolonum [INN-Latin]
Tri-Nasal
Triacet
Triacort
Triam-Tablinen
Triamcet
Triamcinalone
Triamcinlon
Triamcinolon
Triamcinolona
Triamcinolona [INN-Spanish]
Triamcinolone (JP15/USP/INN)
Triamcinolone [USAN:INN:BAN:JAN]
Triamcinolone acetonide
Triamcinolone diacetate
Triamcinolone hexacetonide
Triamcinolonum
Triamcinolonum [INN]
Triatex
Tricortale
Triderm
Trilone
Tristoject
Trymex
UNII-1ZK20VI6TY
Vetalog
Volon
Volon A
WLN: L E5 B666 OV KU MUTJ A1 BF CQ E1 FV1Q FQ GQ
ZINC03882036
droxypregna-1,4-diene-3,20-dione
ione
nchembio.2007.53-comp7
triamcinolone
2
Vitamin Eapproved, nutraceutical, vet_approved40659-02-914985
Synonyms:
(+)-a-Tocopherol
(+)-alpha-Tocopherol
(+)-α-tocopherol
(2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-TRIMETHYLTRIDECYL]CHROMAN-6-OL
(2R)-3,4-Dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-ol
(2R,4'R,8'R)-a-Tocopherol
(2R,4'R,8'R)-alpha-Tocopherol
(2R,4'R,8'R)-α-tocopherol
(R,R,R)-a-Tocopherol
(R,R,R)-alpha-Tocopherol
(R,R,R)-α-tocopherol
5,7,8-Trimethyltocol
5,7,8-trimethyltocol
Amino-Opti-E
Aquasol E
D-alpha-Tocopherol
Daltose
Denamone
E-200 I.U. Softgels
 
E-Complex-600
E-Ferol
E-Vitamin succinate
Eprolin
Gordo-Vite E
Phytogermin
Phytogermine
RRR-alpha-tocopherol
RRR-alpha-tocopheryl
Tocopherol
Vitamin E
Vitamin Ea
Vitamin Plus E Softgells
Vitec
a-D-Tocopherol
a-Tocopherol
alpha-Tocopherol
alpha-delta-Tocopherol
alpha-tocopherol
d-α-tocopherol
delta-alpha-Tocopherol
3Tocopherols406
4Vitamins5095
5Tocotrienols402
6Immunosuppressive Agents12770
7triamcinolone acetonide482
8Triamcinolone diacetate482
9Triamcinolone hexacetonide482
10Hormones, Hormone Substitutes, and Hormone Antagonists12767
11glucocorticoids4920
12Anti-Inflammatory Agents10355
13Hormones13979
14Hormone Antagonists12778
15TocotrienolNutraceutical402
16TocopherolNutraceutical406

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Randomised Multi-centre Study to Compare the Long-term Performance of the Future Hip to 3 Other Implants in Primary Total Hip ReplacementTerminatedNCT00208468Phase 3
2The Long Term Outcome of Varus Derotational Osteotomy for Legg-Calvé-Perthes' DiseaseCompletedNCT02676271
3Diagnosis of Mucopolysaccharidosis Disorders in Patients Presenting With Bilateral Hip DiseaseCompletedNCT01707433
4Taperloc Complete Microplasty vs Taperloc Complete Standard: Randomized Controlled Study on Bone Mineral DensityCompletedNCT02087436
5Multicenter Prospective Cohort Study on Current Treatments of Legg-Calvé-Perthes DiseaseRecruitingNCT02040714
6WOMAC Hip Score in Children and Adolescents With Perthes DiseaseRecruitingNCT02795494
7Evaluate E1 Wear, Clinical Performance of E1 Liner in THA in Korean Patient PopulationActive, not recruitingNCT02087449
8The Effect of Perthes' Disease on Hip CartilageSuspendedNCT00958464
9Intraarticular Corticosteroid Therapy in Perthes Disease.TerminatedNCT01026909

Search NIH Clinical Center for Legg-Calve-Perthes Disease


Cochrane evidence based reviews: legg-calve-perthes disease

Genetic Tests for Legg-Calve-Perthes Disease

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Genetic tests related to Legg-Calve-Perthes Disease:

id Genetic test Affiliating Genes
1 Coxa Plana27

Anatomical Context for Legg-Calve-Perthes Disease

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MalaCards organs/tissues related to Legg-Calve-Perthes Disease:

36
Bone, Skeletal muscle

FMA organs/tissues related to Legg-Calve-Perthes Disease:

17
Hip joint

Publications for Legg-Calve-Perthes Disease

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Articles related to Legg-Calve-Perthes Disease:

(show top 50)    (show all 101)
idTitleAuthorsYear
1
Bilateral Legg-Calve-Perthes Disease and Kienbock's Disease in a Child With Factor V Leiden Thrombophilia: A Case Report. (27698645)
2016
2
Treatment of Late-Onset Legg-Calve-Perthes Disease by Arthrodiastasis. (27904729)
2016
3
Alumina-alumina total hip arthroplasty for the sequelae of Legg-Calve-Perthes disease: A comparative study with adult-onset osteonecrosis. (27522609)
2016
4
Legg-Calve-Perthes disease: A must know entity for anaesthesiologists. (26962263)
2016
5
Comparative study of serum proteomes in Legg-Calve-Perthes disease. (26438379)
2015
6
Treatment of Arthritis Associated With Legg-Calve-Perthes Disease With Modular Total Hip Arthroplasty. (25979188)
2015
7
TAPnnis triple pelvic osteotomy for Legg-Calve-Perthes disease. (25417791)
2015
8
Advanced Containment With Triple Innominate Osteotomy in Legg-Calve-Perthes Disease: A Viable Option Even in Severe Cases. (26683505)
2015
9
Triple osteotomy of the pelvis for Legg-Calve-Perthes disease: a mean fifteen year follow-up. (25645439)
2015
10
Rotational open-wedge osteotomy improves treatment outcomes for patients older than eightA years with Legg-Calve-Perthes disease in the modified lateral pillar B/C border or C group. (25804206)
2015
11
Hypopituitarism and Legg-Calve-Perthes disease related to difficult delivery. (26300943)
2015
12
Guided growth of the trochanteric apophysis combined with soft tissue release for Legg-Calve-Perthes disease. (24563149)
2014
13
Local delivery of recombinant human bone morphogenetic proteins and bisphosphonate via sucrose acetate isobutyrate can prevent femoral head collapse in Legg-Calve-Perthes disease: a pilot study in pigs. (24389948)
2014
14
Increased soluble selectins as a reflection of activated platelets and endothelium in Legg-Calve-Perthes disease. (25000467)
2014
15
Shelf Acetabuloplasty for Containment in the Early Stages of Legg-Calve-Perthes Disease. (24840656)
2014
16
Femoroacetabular impingement". Legg-Calve-Perthes disease: from childhood to adulthood. (25217031)
2014
17
Salter pelvic osteotomy in the treatment of Legg-Calve-Perthes disease: the medium-term results. (24873086)
2014
18
Timing of premature physeal closure in Legg-Calve-Perthes Disease. (24916137)
2014
19
Evolution in diagnosis and treatment of Legg-Calve-Perthes disease. (25207324)
2014
20
Diffusion MRI of the neck of the femur in Legg-Calve-Perthes disease: a preliminary study. (23206418)
2013
21
MR perfusion index as a quantitative method of evaluating epiphyseal perfusion in Legg-Calve-Perthes disease and correlation with short-term radiographic outcome: a preliminary study. (23872796)
2013
22
Custom Cementless THA in Patients With Legg-Calve-Perthes Disease. (24018160)
2013
23
Management of Legg-Calve-Perthes disease with acupuncture: a case report. (23234840)
2013
24
Legg-Calve-Perthes disease in two generations of male family members: a case report. (24014797)
2013
25
Combined osteotomy in patients with severe Legg-Calve-Perthes disease. (23451451)
2012
26
A comparison of the effectiveness of surgical and nonsurgical treatment of legg-calve-perthes disease: a review of the literature. (22953066)
2012
27
Natural history of early onset and late-onset Legg-Calve-Perthes disease. (21857430)
2011
28
Serum prolidase activity and oxidative-antioxidative status in Legg-Calve-Perthes disease. (21304409)
2011
29
Legg-Calve-Perthes disease: etiology, pathogenesis, and biology. (21857428)
2011
30
The role of bracing in Legg-Calve-Perthes disease. (21857435)
2011
31
Femoral varus osteotomy in Legg-Calve-Perthes disease. (21857437)
2011
32
Legg-Calve-Perthes disease centenary. (21857425)
2011
33
Potential for bisphosphonate treatment in Legg-Calve-Perthes disease. (21857436)
2011
34
Prognosis and prognostic factors of Legg-Calve-Perthes disease. (21857429)
2011
35
Labral support shelf arthroplasty for containment in early stages of Legg-Calve-Perthes disease. (21857440)
2011
36
Transtrochanteric rotational osteotomy for late-onset Legg-Calve-Perthes disease. (21857443)
2011
37
Legg-Calve-Perthes disease in a patient with Albright hereditary osteodystrophy: a case report. (20124073)
2010
38
Legg-Calve-Perthes disease and risks for cardiovascular diseases and blood diseases. (20439602)
2010
39
Triple pelvic osteotomy in Legg-Calve-Perthes disease using a single anterolateral incision: a 4-year review. (20386118)
2010
40
Varus producing osteotomy for patients with lateral pillar type B and C Legg-Calve-Perthes disease followed to skeletal maturity. Castaneda et al. JCOR (2008), 2:373-379. (19308615)
2009
41
Triple pelvic osteotomy in the treatment of Legg-Calve-Perthes disease. (19301002)
2009
42
Systemic effects of zoledronic acid in children with traumatic femoral head avascular necrosis and Legg-Calve-Perthes disease. (19446052)
2009
43
Conservative versus surgical treatment of late-onset Legg-Calve-Perthes disease: a radiographic comparison at skeletal maturity. (19308608)
2009
44
Coxa magna quantification using MRI in Legg-Calve-Perthes disease. (18992975)
2009
45
MRI of Legg-Calve-Perthes disease. (19843759)
2009
46
Thrombomodulin and GFC levels in Legg-Calve-Perthes disease. (19055859)
2008
47
A histological and ultrastructural study of the iliac crest apophysis in Legg-Calve-Perthes disease. (18520280)
2008
48
Sagittal spinal alignment in patients with Legg-Calve-Perthes disease. (17875086)
2007
49
Interruption of the blood supply of femoral head: an experimental study on the pathogenesis of Legg-Calve-Perthes Disease. (17598118)
2007
50
A recurrent mutation in type II collagen gene causes Legg-Calve- Perthes disease in a Japanese family. (17394019)
2007

Variations for Legg-Calve-Perthes Disease

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Clinvar genetic disease variations for Legg-Calve-Perthes Disease:

5
id Gene Variation Type Significance SNP ID Assembly Location
1COL2A1NM_001844.4(COL2A1): c.3508G> A (p.Gly1170Ser)SNVPathogenicrs121912891GRCh37Chr 12, 48369835: 48369835

Expression for genes affiliated with Legg-Calve-Perthes Disease

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Search GEO for disease gene expression data for Legg-Calve-Perthes Disease.

Pathways for genes affiliated with Legg-Calve-Perthes Disease

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GO Terms for genes affiliated with Legg-Calve-Perthes Disease

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Cellular components related to Legg-Calve-Perthes Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:003101210.0APOH, COL2A1, SERPINE1
2platelet alpha granule lumenGO:00310939.5F5, SERPINE1
3extracellular regionGO:00055769.1APOH, COL2A1, F5, SERPINC1, SERPINE1
4plasma membraneGO:00058867.2APOH, CD40LG, F5, SELE, SERPINC1, SERPINE1
5extracellular spaceGO:00056157.2APOH, CD40LG, COL2A1, F5, SELE, SERPINC1

Biological processes related to Legg-Calve-Perthes Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1blood coagulationGO:00075969.8F5, SERPINC1, THBD
2negative regulation of blood coagulationGO:00301959.6APOH, SERPINE1, THBD
3negative regulation of fibrinolysisGO:00519189.6APOH, SERPINE1, THBD
4leukocyte cell-cell adhesionGO:00071599.6CD40LG, SELE
5positive regulation of blood coagulationGO:00301949.5APOH, SERPINE1
6platelet degranulationGO:00025769.3APOH, F5, SERPINE1

Sources for Legg-Calve-Perthes Disease

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet