LCPD
MCID: LGG001
MIFTS: 57

Legg-Calve-Perthes Disease (LCPD) malady

Categories: Genetic diseases, Rare diseases, Bone diseases

Aliases & Classifications for Legg-Calve-Perthes Disease

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Sources:
11Disease Ontology, 12diseasecard, 13DISEASES, 25Genetics Home Reference, 27GTR, 30ICD10, 31ICD10 via Orphanet, 37MedGen, 39MeSH, 45NCIt, 48NIH Rare Diseases, 50Novoseek, 52OMIM, 54Orphanet, 62SNOMED-CT, 68UMLS, 69UMLS via Orphanet, 70UniProtKB/Swiss-Prot
See all MalaCards sources

Aliases & Descriptions for Legg-Calve-Perthes Disease:

Name: Legg-Calve-Perthes Disease 52 11 48 70 12 39 13 68
Perthes Disease 11 48 25 54 70 50
Coxa Plana 11 48 25 27
Lcpd 48 25 70
Legg-Calvé-Perthes Disease 25 54
Avascular Necrosis of the Capital Femoral Epiphysis 68
Aseptic Necrosis of the Capital Femoral Epiphysis 54
Osteochondrosis of the Capital Femoral Epiphysis 54
Osteochondritis of the Capital Femoral Epiphysis 54
Juvenile Osteochondrosis of Hip and/or Pelvis 11
Juvenile Osteochondrosis of Hip and Pelvis 11
 
Osteochondrosis of Legg-Calve-Perthes 11
Juvenile Osteochond-Hip/pelvis 11
Legg-Calve-Perthes Syndrome 48
Legg-Calve-Perthes Symptom 11
Osteochondritis Deformans 48
Calve - Perthes' Disease 11
Calve-Perthes Disease 25
Legg-Perthes Disease 70
Perthe's Disease 11
Pseudocoxalgia 11

Characteristics:

Orphanet epidemiological data:

54
perthes disease:
Inheritance: Autosomal dominant,Multigenic/multifactorial; Age of onset: Childhood; Age of death: normal life expectancy

Classifications:



External Ids:

OMIM52 150600
Disease Ontology11 DOID:14415
ICD1030 M91.2, M91.3, M91
MeSH39 D007873
NCIt45 C34766
Orphanet54 ORPHA2380
UMLS via Orphanet69 C0023234
ICD10 via Orphanet31 M91.1
MedGen37 C0023234

Summaries for Legg-Calve-Perthes Disease

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NIH Rare Diseases:48 Legg-calve-perthes disease (lcpd) occurs when blood supply to the ball of the thighbone in the hip (femoral head) is disrupted. without an adequate blood supply, the bone cells die. lcpd usually occurs in children between the ages of 4 and 10. early symptoms may include limping; pain in the hip, thigh or knee; and reduced range of hip motion. later in the disease course, there may be leg length discrepancy (one leg longer than the other) and wasting of the muscles around the hip. the condition can last for several years before new bone formation (re-ossification) and eventual healing occurs. some people with lcpd go on to develop degenerative arthritis in adulthood. the underlying cause of lcpd is often not known. sometimes it results from a slipped capital femoral epiphysis, trauma, steroid use, sickle-cell crisis, toxic synovitis, or congenital hip dysplasia. it usually is not caused by genetic factors, but a few familial cases with autosomal dominant inheritance have been reported. in a small percentage of cases, mutations in the col2a1 gene were found to be responsible. treatment aims to keep the thigh bone inside the hip socket. treatment options may include rest or medication for pain; physical therapy; using a brace; or surgery. last updated: 7/28/2016

MalaCards based summary: Legg-Calve-Perthes Disease, also known as perthes disease, is related to arthrogryposis, perthes disease, and upward gaze palsy and garret tripp syndrome, and has symptoms including Array, Array and Array. An important gene associated with Legg-Calve-Perthes Disease is COL2A1 (Collagen Type II Alpha 1 Chain), and among its related pathways are Malaria and Collagen chain trimerization. Affiliated tissues include hip joint, bone and skeletal muscle, and related mouse phenotypes are embryo and liver/biliary system.

UniProtKB/Swiss-Prot:70 Legg-Calve-Perthes disease: Characterized by loss of circulation to the femoral head, resulting in avascular necrosis in a growing child. Clinical pictures of the disease vary, depending on the phase of disease progression through ischemia, revascularization, fracture and collapse, and repair and remodeling of the bone.

OMIM:52 Legg-Calve-Perthes disease is characterized by loss of circulation to the femoral head, resulting in avascular necrosis... (150600) more...

Disease Ontology:11 An osteochondrosis that results in death and fracture located in hip joint.

Related Diseases for Legg-Calve-Perthes Disease

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Diseases related to Legg-Calve-Perthes Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 131)
idRelated DiseaseScoreTop Affiliating Genes
1arthrogryposis, perthes disease, and upward gaze palsy12.2
2garret tripp syndrome10.8
3upington disease10.5
4osteochondritis dissecans10.3
5thrombophilia10.3
6brazilian hemorrhagic fever10.2SERPINC1, SERPINE1
7ductal carcinoma in situ10.2SERPINC1, THBD
8midline cystocele10.2SERPINC1, SERPINE1
9secretory diarrhea myopathy and deafness10.2SERPINC1, SERPINE1
10pancreatic ductal carcinoma10.2F5, SERPINC1
11may-hegglin anomaly10.2APOH, SERPINC1
12myosclerosis, congenital10.2F5, SERPINC1
13monocular exotropia10.2SERPINC1, SERPINE1
14spinal cord lipoma10.2APOH, SERPINC1
15septic myocarditis10.2SERPINC1, THBD
16absence of innominate vein10.2F5, SERPINE1
17aminoaciduria10.2F5, SERPINE1
18med13l syndrome10.1APOH, F5
19achard thiers syndrome10.1APOH, F5
20sialadenitis10.1APOH, THBD
21inherited blood coagulation disease10.1F5, SERPINE1
22supraumbilical midabdominal raphe and facial cavernous hemangiomas10.1APOH, F5
23multiple epiphyseal dysplasia10.1
24lung cancer10.1APOH, F5
25microphthalmia, isolated, with coloboma 1010.1F5, SERPINE1
26hendra virus infection10.1APOH, F5
27de quervain disease10.1SELE, THBD
28pancreas adenocarcinoma10.1COL2A1, SERPINC1, SERPINE1
29avascular necrosis of the femoral head10.1
30arthritis10.1
31osteochondrosis10.1
32osteonecrosis10.1
33exostosis10.1
34synovitis10.1
35hypopituitarism10.1
36factor v leiden thrombophilia10.1
37kienbock's disease10.1
38pandas10.1
39chromosomal disease10.1COL2A1, SERPINE1
40craniosynostosis 310.1PEPD, SELE
41cetp-related hyperalphalipoproteinemia10.1SELE, SERPINE1
42cysticercosis10.1CD40LG, SERPINC1
43zika virus congenital syndrome10.1SERPINC1, SERPINE1, THBD
44atherosclerosis10.1APOH, SELE
45chronic thromboembolic pulmonary hypertension10.1SELE, THBD
46freiberg's disease10.1CD40LG, SERPINC1
47hereditary endotheliopathy, retinopathy, nephropathy, and stroke10.1CD40LG, SERPINC1
48pedophilia10.1CD40LG, COL2A1
49herpes simplex10.1APOH, COL2A1, THBD
50eagle syndrome10.1F5, SERPINC1, THBD

Graphical network of the top 20 diseases related to Legg-Calve-Perthes Disease:



Diseases related to legg-calve-perthes disease

Symptoms & Phenotypes for Legg-Calve-Perthes Disease

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Symptoms by clinical synopsis from OMIM:

150600

Clinical features from OMIM:

150600

Human phenotypes related to Legg-Calve-Perthes Disease:

 54 64 (show all 9)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 abnormality of the teeth64 54 Very frequent (99-80%) HP:0000164
2 joint dislocation64 54 Very frequent (99-80%) HP:0001373
3 delayed skeletal maturation64 54 Very frequent (99-80%) HP:0002750
4 arthralgia64 54 Very frequent (99-80%) HP:0002829
5 skeletal muscle atrophy64 54 Very frequent (99-80%) HP:0003202
6 short stature64 54 Very frequent (99-80%) HP:0004322
7 aseptic necrosis64 54 Very frequent (99-80%) HP:0010885
8 cartilage destruction64 54 Very frequent (99-80%) HP:0100773
9 avascular necrosis of the capital femoral epiphysis64 HP:0005743

MGI Mouse Phenotypes related to Legg-Calve-Perthes Disease according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053809.4COL2A1, F5, PEPD, SERPINC1, THBD
2MP:00053708.4COL2A1, F5, SELE, SERPINC1, SERPINE1, THBD
3MP:00107718.2CD40LG, F5, PEPD, SELE, SERPINE1, THBD
4MP:00053678.0CD40LG, COL2A1, PEPD, SERPINC1, SERPINE1, THBD
5MP:00053878.0CD40LG, COL2A1, PEPD, SELE, SERPINC1, SERPINE1
6MP:00053857.6CD40LG, COL2A1, F5, PEPD, SELE, SERPINC1
7MP:00053766.9APOH, CD40LG, COL2A1, F5, PEPD, SELE
8MP:00107686.8APOH, CD40LG, COL2A1, F5, PEPD, SELE

Drugs & Therapeutics for Legg-Calve-Perthes Disease

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Drugs for Legg-Calve-Perthes Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Triamcinoloneapproved, vet_approved510124-94-731307
Synonyms:
(8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
11-beta,16-alpha,17-alpha,21-Tetrahydroxy-9-alpha-fluoro-1,4-pregnadiene-3,20-dione
11.Beta.,16.alpha.,17.alpha., 21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione
11.beta.,16.alpha.,17.alpha.,21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione
11β,16α,17α,21-tetrahydroxy-9α-fluoro-1,4-pregnadiene-3,20-dione
124-94-7
4-08-00-03629 (Beilstein Handbook Reference)
83474-03-7
9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-alpha-Fluoro-11-beta,16-alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-alpha-Fluoro-16-alpha-hydroxyprednisolone
9-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9.Alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahy
9.Alpha.-Fluoro-11.beta.,16.alpha.,17.alpha., 21-tetrahydroxypregna-1,4-diene-3,20-d
9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione
9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9.alpha.-Fluoro-11.beta.,16.alpha.,17.alpha.,21-tetrahydroxypregna-1,4-diene-3,20-dione
9.alpha.-Fluoro-16.alpha.-hydroxyprednisolone
9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione
9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9alpha-Fluoro-16alpha-hydroxyprednisolone
9α-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9α-fluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione
9α-fluoro-16α-hydroxyprednisolone
AC-2072
AC1L1LDH
AC1Q5HJC
Adcortyl
Aristocort
Aristocort A
Aristocort Tablets
Aristogel
Aristospan
Azmacort
BPBio1_000154
BRD-K77554836-001-03-3
BRN 2341955
BSPBio_000140
Bio-0662
C21H27FO6
CHEMBL1451
CID31307
CL 19823
Celeste
Cinolone
Cinolone-T
D00385
D014221
DB00620
Delphicort
EINECS 204-718-7
EU-0101179
Fluoxiprednisolone
Fluoxyprednisolone
Flutex
Fougera
HMS1568G22
HMS2090D12
HSDB 3194
Kenacort
Kenacort (TN)
Kenacort-A
Kenacort-AG
Kenacort-Ag
Kenalog
Kenalog in Orabase
Kenalog-10
Kenalog-40
Kenalog-H
LS-698
Ledercort
Lopac0_001179
 
MLS000028542
MLS001066543
MLS002695935
MolPort-002-528-981
Mycolog
NCGC00021580-03
NCGC00021580-04
NCGC00021580-05
NCGC00021580-06
NCGC00021580-07
NCI60_000750
NSC 13397
NSC13397
Nasacort
Nasacort Aq
Nasacort Hfa
Omcilon
Omicilon
Oracort
Oralone
Orion
Polcortolon
Pregna-1,4-diene-3,20-dio
Pregna-1,4-diene-3,20-dione, 9-fluoro-11,16,17,21-tetrahydroxy-, (11beta,16alpha)
Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,16alpha,17,21-tetrahydroxy- (8CI)
Prestwick0_000120
Prestwick1_000120
Prestwick2_000120
Prestwick3_000120
Prestwick_438
Rodinolone
S1933_Selleck
SK-Triamcinolone
SMP1_000300
SMR000058333
SPBio_002079
Sk-Triamcinolone
T6376_SIGMA
TRIAMCINOLONE (SEE ALSO TRIAMCINOLONE ACETONIDE (76-25-5) AND TRIAMCINOLONE DIACETATE (67-78-7))
Tiamcinolonum
Tiamcinolonum [INN-Latin]
Tri-Nasal
Triacet
Triacort
Triam-Tablinen
Triamcet
Triamcinalone
Triamcinlon
Triamcinolon
Triamcinolona
Triamcinolona [INN-Spanish]
Triamcinolone (JP15/USP/INN)
Triamcinolone [USAN:INN:BAN:JAN]
Triamcinolone acetonide
Triamcinolone diacetate
Triamcinolone hexacetonide
Triamcinolonum
Triamcinolonum [INN]
Triatex
Tricortale
Triderm
Trilone
Tristoject
Trymex
UNII-1ZK20VI6TY
Vetalog
Volon
Volon A
WLN: L E5 B666 OV KU MUTJ A1 BF CQ E1 FV1Q FQ GQ
ZINC03882036
droxypregna-1,4-diene-3,20-dione
ione
nchembio.2007.53-comp7
triamcinolone
2
Vitamin Eapproved, nutraceutical, vet_approved41459-02-914985
Synonyms:
(+)-a-Tocopherol
(+)-alpha-Tocopherol
(+)-α-tocopherol
(2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-TRIMETHYLTRIDECYL]CHROMAN-6-OL
(2R)-3,4-Dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-ol
(2R,4'R,8'R)-a-Tocopherol
(2R,4'R,8'R)-alpha-Tocopherol
(2R,4'R,8'R)-α-tocopherol
(R,R,R)-a-Tocopherol
(R,R,R)-alpha-Tocopherol
(R,R,R)-α-tocopherol
5,7,8-Trimethyltocol
5,7,8-trimethyltocol
Amino-Opti-E
Aquasol E
D-alpha-Tocopherol
Daltose
Denamone
E-200 I.U. Softgels
 
E-Complex-600
E-Ferol
E-Vitamin succinate
Eprolin
Gordo-Vite E
Phytogermin
Phytogermine
RRR-alpha-tocopherol
RRR-alpha-tocopheryl
Tocopherol
Vitamin E
Vitamin Ea
Vitamin Plus E Softgells
Vitec
a-D-Tocopherol
a-Tocopherol
alpha-Tocopherol
alpha-delta-Tocopherol
alpha-tocopherol
d-α-tocopherol
delta-alpha-Tocopherol
3Tocopherols414
4Vitamins5282
5Tocotrienols410
6Immunosuppressive Agents13086
7triamcinolone acetonide510
8Triamcinolone diacetate510
9Triamcinolone hexacetonide510
10Hormones, Hormone Substitutes, and Hormone Antagonists13168
11glucocorticoids5103
12Anti-Inflammatory Agents10729
13Hormones14415
14Hormone Antagonists13180
15TocotrienolNutraceutical410
16TocopherolNutraceutical414

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Randomised Multi-centre Study to Compare the Long-term Performance of the Future Hip to 3 Other Implants in Primary Total Hip ReplacementTerminatedNCT00208468Phase 3
2The Long Term Outcome of Varus Derotational Osteotomy for Legg-Calvé-Perthes' DiseaseCompletedNCT02676271
3Diagnosis of Mucopolysaccharidosis Disorders in Patients Presenting With Bilateral Hip DiseaseCompletedNCT01707433
4Multicenter Prospective Cohort Study on Current Treatments of Legg-Calvé-Perthes DiseaseRecruitingNCT02040714
5WOMAC Hip Score in Children and Adolescents With Perthes DiseaseRecruitingNCT02795494
6Evaluate E1 Wear, Clinical Performance of E1 Liner in THA in Korean Patient PopulationActive, not recruitingNCT02087449
7Taperloc Complete Microplasty vs Taperloc Complete Standard: Randomized Controlled Study on Bone Mineral DensityActive, not recruitingNCT02087436
8The Effect of Perthes' Disease on Hip CartilageSuspendedNCT00958464
9Intraarticular Corticosteroid Therapy in Perthes Disease.TerminatedNCT01026909

Search NIH Clinical Center for Legg-Calve-Perthes Disease


Cochrane evidence based reviews: legg-calve-perthes disease

Genetic Tests for Legg-Calve-Perthes Disease

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Genetic tests related to Legg-Calve-Perthes Disease:

id Genetic test Affiliating Genes
1 Coxa Plana27

Anatomical Context for Legg-Calve-Perthes Disease

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MalaCards organs/tissues related to Legg-Calve-Perthes Disease:

36
Bone, Skeletal muscle

FMA organs/tissues related to Legg-Calve-Perthes Disease:

17
Hip joint

Publications for Legg-Calve-Perthes Disease

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Articles related to Legg-Calve-Perthes Disease:

(show top 50)    (show all 102)
idTitleAuthorsYear
1
Synovial osteochondromatosis in a 14-year-old boy with a history of Legg-Calve-Perthes disease. (28491198)
2017
2
Legg-Calve-Perthes disease: A must know entity for anaesthesiologists. (26962263)
2016
3
Bilateral Legg-Calve-Perthes Disease and Kienbock's Disease in a Child With Factor V Leiden Thrombophilia: A Case Report. (27698645)
2016
4
Treatment of Late-Onset Legg-Calve-Perthes Disease by Arthrodiastasis. (27904729)
2016
5
Alumina-alumina total hip arthroplasty for the sequelae of Legg-Calve-Perthes disease: A comparative study with adult-onset osteonecrosis. (27522609)
2016
6
Rotational open-wedge osteotomy improves treatment outcomes for patients older than eightA years with Legg-Calve-Perthes disease in the modified lateral pillar B/C border or C group. (25804206)
2015
7
TAPnnis triple pelvic osteotomy for Legg-Calve-Perthes disease. (25417791)
2015
8
Comparative study of serum proteomes in Legg-Calve-Perthes disease. (26438379)
2015
9
Hypopituitarism and Legg-Calve-Perthes disease related to difficult delivery. (26300943)
2015
10
Advanced Containment With Triple Innominate Osteotomy in Legg-Calve-Perthes Disease: A Viable Option Even in Severe Cases. (26683505)
2015
11
Treatment of Arthritis Associated With Legg-Calve-Perthes Disease With Modular Total Hip Arthroplasty. (25979188)
2015
12
Triple osteotomy of the pelvis for Legg-Calve-Perthes disease: a mean fifteen year follow-up. (25645439)
2015
13
Guided growth of the trochanteric apophysis combined with soft tissue release for Legg-Calve-Perthes disease. (24563149)
2014
14
Timing of premature physeal closure in Legg-Calve-Perthes Disease. (24916137)
2014
15
Local delivery of recombinant human bone morphogenetic proteins and bisphosphonate via sucrose acetate isobutyrate can prevent femoral head collapse in Legg-Calve-Perthes disease: a pilot study in pigs. (24389948)
2014
16
Evolution in diagnosis and treatment of Legg-Calve-Perthes disease. (25207324)
2014
17
Increased soluble selectins as a reflection of activated platelets and endothelium in Legg-Calve-Perthes disease. (25000467)
2014
18
Femoroacetabular impingement". Legg-Calve-Perthes disease: from childhood to adulthood. (25217031)
2014
19
Salter pelvic osteotomy in the treatment of Legg-Calve-Perthes disease: the medium-term results. (24873086)
2014
20
Shelf Acetabuloplasty for Containment in the Early Stages of Legg-Calve-Perthes Disease. (24840656)
2014
21
Legg-Calve-Perthes disease in two generations of male family members: a case report. (24014797)
2013
22
Custom Cementless THA in Patients With Legg-Calve-Perthes Disease. (24018160)
2013
23
Management of Legg-Calve-Perthes disease with acupuncture: a case report. (23234840)
2013
24
MR perfusion index as a quantitative method of evaluating epiphyseal perfusion in Legg-Calve-Perthes disease and correlation with short-term radiographic outcome: a preliminary study. (23872796)
2013
25
Diffusion MRI of the neck of the femur in Legg-Calve-Perthes disease: a preliminary study. (23206418)
2013
26
Combined osteotomy in patients with severe Legg-Calve-Perthes disease. (23451451)
2012
27
A comparison of the effectiveness of surgical and nonsurgical treatment of legg-calve-perthes disease: a review of the literature. (22953066)
2012
28
Transtrochanteric rotational osteotomy for late-onset Legg-Calve-Perthes disease. (21857443)
2011
29
Prognosis and prognostic factors of Legg-Calve-Perthes disease. (21857429)
2011
30
Potential for bisphosphonate treatment in Legg-Calve-Perthes disease. (21857436)
2011
31
Legg-Calve-Perthes disease centenary. (21857425)
2011
32
Femoral varus osteotomy in Legg-Calve-Perthes disease. (21857437)
2011
33
Legg-Calve-Perthes disease: etiology, pathogenesis, and biology. (21857428)
2011
34
Labral support shelf arthroplasty for containment in early stages of Legg-Calve-Perthes disease. (21857440)
2011
35
Serum prolidase activity and oxidative-antioxidative status in Legg-Calve-Perthes disease. (21304409)
2011
36
The role of bracing in Legg-Calve-Perthes disease. (21857435)
2011
37
Natural history of early onset and late-onset Legg-Calve-Perthes disease. (21857430)
2011
38
Triple pelvic osteotomy in Legg-Calve-Perthes disease using a single anterolateral incision: a 4-year review. (20386118)
2010
39
Legg-Calve-Perthes disease and risks for cardiovascular diseases and blood diseases. (20439602)
2010
40
Legg-Calve-Perthes disease in a patient with Albright hereditary osteodystrophy: a case report. (20124073)
2010
41
Conservative versus surgical treatment of late-onset Legg-Calve-Perthes disease: a radiographic comparison at skeletal maturity. (19308608)
2009
42
Coxa magna quantification using MRI in Legg-Calve-Perthes disease. (18992975)
2009
43
Systemic effects of zoledronic acid in children with traumatic femoral head avascular necrosis and Legg-Calve-Perthes disease. (19446052)
2009
44
Varus producing osteotomy for patients with lateral pillar type B and C Legg-Calve-Perthes disease followed to skeletal maturity. Castaneda et al. JCOR (2008), 2:373-379. (19308615)
2009
45
Triple pelvic osteotomy in the treatment of Legg-Calve-Perthes disease. (19301002)
2009
46
MRI of Legg-Calve-Perthes disease. (19843759)
2009
47
Thrombomodulin and GFC levels in Legg-Calve-Perthes disease. (19055859)
2008
48
A histological and ultrastructural study of the iliac crest apophysis in Legg-Calve-Perthes disease. (18520280)
2008
49
Sagittal spinal alignment in patients with Legg-Calve-Perthes disease. (17875086)
2007
50
Legg-Calve-Perthes disease, venous and arterial thrombi, and the factor V Leiden mutation in a four-generation kindred. (17878795)
2007

Variations for Legg-Calve-Perthes Disease

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UniProtKB/Swiss-Prot genetic disease variations for Legg-Calve-Perthes Disease:

70
id Symbol AA change Variation ID SNP ID
1COL2A1p.Gly1170SerVAR_023933rs121912891

Clinvar genetic disease variations for Legg-Calve-Perthes Disease:

5
id Gene Variation Type Significance SNP ID Assembly Location
1COL2A1NM_ 001844.4(COL2A1): c.3508G> A (p.Gly1170Ser)SNVPathogenicrs121912891GRCh37Chr 12, 48369835: 48369835

Expression for genes affiliated with Legg-Calve-Perthes Disease

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Search GEO for disease gene expression data for Legg-Calve-Perthes Disease.

Pathways for genes affiliated with Legg-Calve-Perthes Disease

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GO Terms for genes affiliated with Legg-Calve-Perthes Disease

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Cellular components related to Legg-Calve-Perthes Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum lumenGO:000578810.1COL2A1, F5, SERPINC1
2extracellular matrixGO:00310129.9APOH, COL2A1, SERPINE1
3extracellular regionGO:00055768.4APOH, CD40LG, COL2A1, F5, SERPINC1, SERPINE1
4extracellular spaceGO:00056156.5APOH, CD40LG, COL2A1, F5, SELE, SERPINC1

Biological processes related to Legg-Calve-Perthes Disease according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1blood coagulationGO:00075969.8F5, SERPINC1, THBD
2hemostasisGO:00075999.8F5, SERPINC1, THBD
3positive regulation of blood coagulationGO:00301949.7APOH, SERPINE1
4leukocyte cell-cell adhesionGO:00071599.7CD40LG, SELE
5negative regulation of blood coagulationGO:00301959.6APOH, SERPINE1, THBD
6negative regulation of fibrinolysisGO:00519189.6APOH, SERPINE1, THBD
7regulation of blood coagulationGO:00301939.5APOH, SERPINC1
8platelet degranulationGO:00025769.3APOH, F5, SERPINE1

Sources for Legg-Calve-Perthes Disease

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2CDC
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10DGIdb
15ExPASy
16FDA
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27GTR
28HGMD
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67Tumor Gene Family of Databases
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