LCPD
MCID: LGG001
MIFTS: 56

Legg-Calve-Perthes Disease (LCPD) malady

Bone category

Summaries for Legg-Calve-Perthes Disease

Sources:
8Disease Ontology, 43NIH Rare Diseases, 47OMIM, 33MalaCards
See all sources

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NIH Rare Diseases:43 Legg-calve-perthes disease occurs when the ball of the thighbone in the hip doesn’t get enough blood, causing the bone to die. early symptoms may include mildly painful limp, pain down the inner thigh to the knee, some restriction of hip movement, pain at extremes of movement, and tenderness over the hip joint. treatment may include a brief period of bed rest (1 to 3 days) followed by bracing. rarely bracing may be required for 2 to 3 years. chance of recovery (prognosis) varies, but tends to be better for younger patients (e.g., less than 6 years of age). some people with this syndrome go on to develop degenerative arthritis. the cause of the condition is unknown. last updated: 1/6/2011

MalaCards: Legg-Calve-Perthes Disease, also known as perthes disease, is related to vascular disease and thrombophilia, and has symptoms including abnormal dentition/dental position/implantation/unerupted/dental ankylosis, muscle hypotrophy/atrophy/dystrophy/agenesis/amyotrophy and delayed bone age. An important gene associated with Legg-Calve-Perthes Disease is COL2A1 (collagen, type II, alpha 1), and among its related pathways are Common Pathway and Platelet activation, signaling and aggregation. The compounds warfarin and sarpogrelate hydrochloride have been mentioned in the context of this disorder. Affiliated tissues include hip joint, and related mouse phenotype liver/biliary system.

Disease Ontology:8 An osteochondrosis that results in death and fracture located in hip joint.

Description from OMIM:47 150600

Aliases & Classifications for Legg-Calve-Perthes Disease

Sources:
61UMLS, 8Disease Ontology, 9diseasecard, 43NIH Rare Diseases, 47OMIM, 10DISEASES, 45Novoseek, 49Orphanet, 22GTR, 57SNOMED-CT, 40NCIt, 35MeSH, 26ICD10 via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone


Characteristics (Orphanet epidemiological data):

49
perthes disease:
Inheritance: Autosomal dominant,Multigenic/multifactorial; Age of onset: Childhood; Age of death: Normal


Aliases & Descriptions:

legg-calve-perthes disease 8 9 43 47 10 61
perthes disease 8 43 45 49
coxa plana 8 43 22
avascular necrosis of the capital femoral epiphysis 61
aseptic necrosis of the capital femoral epiphysis 49
osteochondrosis of the capital femoral epiphysis 49
osteochondritis of the capital femoral epiphysis 49
juvenile osteochondrosis of hip and/or pelvis 8
juvenile osteochondrosis of tibial tubercle 61
juvenile osteochondrosis of hip and pelvis 8
osteochondrosis of legg-calve-perthes 8
juvenile osteochond-hip/pelvis 8
legg-calvé-perthes disease 49
legg-calve-perthes syndrome 43
osteochondritis deformans 43
calve - perthes' disease 8
perthe's disease 8
pseudocoxalgia 8
lcpd 43


External Ids:

Disease Ontology8 DOID:14415
NCIt40 C34766
OMIM47 150600
MeSH35 D007873
ICD10 via Orphanet26 M91.1
ICD1025 M91, M91.2, M91.3

Related Diseases for Legg-Calve-Perthes Disease

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Legg-Calve-Perthes Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 304)
idRelated DiseaseScoreTop Affiliating Genes
1vascular disease30.6SERPINC1, THBD
2thrombophilia30.6F5, SERPINC1, THBD, SERPINE1
3protein c deficiency30.6SERPINE1, THBD, F5, SERPINC1
4osteochondritis dissecans10.7
5osgood-schlatter's disease10.6
6metachondromatosis10.6
7kienbock's disease10.4
8osteochondritis of tarsal/metatarsal bone10.4
9thiemann disease, familial form10.4
10panner disease10.4
11sinding-larsen-johansson disease10.4
12synovitis10.4
13slipped capital femoral epiphysis10.4
14multiple epiphyseal dysplasia10.4
15protein r deficiency10.3
16type vi ehlers-danlos syndrome10.2
17achondroplasia10.2
18osteoarthritis10.2
19devic disease10.2
20osteochondroma10.2
21diastrophic dysplasia10.1
22thrombocytopenia-absent radius syndrome10.1
23smith-lemli-opitz syndrome10.1
24rothmund-thomson syndrome10.1
25rubinstein-taybi syndrome10.1
26coffin-siris syndrome10.1
27cutis laxa10.1
28cartilage-hair hypoplasia10.1
29trichorhinophalangeal syndrome type i10.1
30weaver syndrome10.1
31mucopolysaccharidosis iv10.1
32sly syndrome10.1
33mucopolysaccharidosis iii10.1
34mucopolysaccharidosis ii10.1
35trichorhinophalangeal syndrome type ii10.1
36camurati-engelmann disease10.1
37campomelic dysplasia10.1
38spondyloepimetaphyseal dysplasia, sponastrime type10.1
39borjeson-forssman-lehmann syndrome10.1
40arterial tortuosity syndrome10.1
41distal arthrogryposis10.1
42edwards syndrome10.1
43oculocerebrorenal syndrome10.1
44aicardi syndrome10.1
45infectious mononucleosis10.1
46acrocapitofemoral dysplasia10.1
47kniest dysplasia10.1
48spondyloepimetaphyseal dysplasia, missouri type10.1
49acromesomelic dysplasia, hunter-thompson type10.1
50albright's hereditary osteodystrophy10.1

Graphical network of the top 20 diseases related to Legg-Calve-Perthes Disease:



Diseases related to legg-calve-perthes disease

Clinical Features for Legg-Calve-Perthes Disease

Sources:
47OMIM, 49Orphanet
See all sources

Clinical features from OMIM:

150600

Clinical synopsis from OMIM:

150600

Symptoms:

49 (show all 9)
  • abnormal dentition/dental position/implantation/unerupted/dental ankylosis
  • muscle hypotrophy/atrophy/dystrophy/agenesis/amyotrophy
  • delayed bone age
  • osteonecrosis/bone infarction
  • articular/joint pain/arthralgia
  • joint/articular deformation
  • cartilage destruction/chondrolysis
  • polygenic/multifactorial inheritance
  • short stature/dwarfism/nanism

Drugs & Therapeutics for Legg-Calve-Perthes Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Legg-Calve-Perthes Disease

Drug clinical trials:

Search ClinicalTrials for Legg-Calve-Perthes Disease

Search NIH Clinical Center for Legg-Calve-Perthes Disease

Search CenterWatch for Legg-Calve-Perthes Disease

Genetic Tests for Legg-Calve-Perthes Disease

Sources:
22GTR
See all sources

Genetic tests related to Legg-Calve-Perthes Disease:

id Genetic test Affiliating Genes
1 Coxa Plana22

Anatomical Context for Legg-Calve-Perthes Disease

Sources:
14FMA
See all sources

FMA organs/tissues related to Legg-Calve-Perthes Disease:

14
Hip joint

Animal Models for Legg-Calve-Perthes Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Legg-Calve-Perthes Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.8SERPINC1, SERPINE1, THBD, F5, PHIP, COL2A1

Publications for Legg-Calve-Perthes Disease

Sources:
51PubMed
See all sources

Articles related to Legg-Calve-Perthes Disease:

(show top 50)    (show all 83)
idTitleAuthorsYear
1
Local delivery of recombinant human bone morphogenetic proteins and bisphosphonate via sucrose acetate isobutyrate can prevent femoral head collapse in Legg-Calve-Perthes disease: a pilot study in pigs. (24389948)
2014
2
Management of Legg-Calve-Perthes disease with acupuncture: a case report. (23234840)
2013
3
MR perfusion index as a quantitative method of evaluating epiphyseal perfusion in Legg-Calve-Perthes disease and correlation with short-term radiographic outcome: a preliminary study. (23872796)
2013
4
Combined osteotomy in patients with severe Legg-Calve-Perthes disease. (23451451)
2012
5
A comparison of the effectiveness of surgical and nonsurgical treatment of legg-calve-perthes disease: a review of the literature. (22953066)
2012
6
Natural history of early onset and late-onset Legg-Calve-Perthes disease. (21857430)
2011
7
Femoral varus osteotomy in Legg-Calve-Perthes disease. (21857437)
2011
8
Legg-Calve-Perthes disease centenary. (21857425)
2011
9
Legg-Calve-Perthes disease: etiology, pathogenesis, and biology. (21857428)
2011
10
Transtrochanteric rotational osteotomy for late-onset Legg-Calve-Perthes disease. (21857443)
2011
11
Legg-Calve-Perthes disease in a patient with Albright hereditary osteodystrophy: a case report. (20124073)
2010
12
Legg-Calve-Perthes disease and risks for cardiovascular diseases and blood diseases. (20439602)
2010
13
Varus producing osteotomy for patients with lateral pillar type B and C Legg-Calve-Perthes disease followed to skeletal maturity. Castaneda et al. JCOR (2008), 2:373-379. (19308615)
2009
14
Coxa magna quantification using MRI in Legg-Calve-Perthes disease. (18992975)
2009
15
MRI of Legg-Calve-Perthes disease. (19843759)
2009
16
Systemic effects of zoledronic acid in children with traumatic femoral head avascular necrosis and Legg-Calve-Perthes disease. (19446052)
2009
17
Sagittal spinal alignment in patients with Legg-Calve-Perthes disease. (17875086)
2007
18
Interruption of the blood supply of femoral head: an experimental study on the pathogenesis of Legg-Calve-Perthes Disease. (17598118)
2007
19
Legg-calve-perthes disease: a review of cases with onset before six years of age. (18056504)
2007
20
Outcome of cheilectomy in Legg-Calve-Perthes disease: minimum 25-year follow-up of five patients. (16557136)
2006
21
Protein C levels in patients with Legg-Calve-Perthes disease: is it a true deficiency? (16557135)
2006
22
Residual shortening after Legg-Calve-Perthes disease, focusing on the response of the ipsilateral tibia. (15832141)
2005
23
Automated analysis of MR image of hip: geometrical evaluation of the Legg-Calve-Perthes disease. (15863350)
2005
24
Arthroscopic findings of the hip in new onset hip pain in adolescents with previous Legg-Calve-Perthes disease. (15812283)
2005
25
The correlation between coxa magna and final outcome in Legg-Calve-Perthes disease. (15614054)
2005
26
Leg length discrepancy in Legg-Calve-Perthes disease. (15718903)
2005
27
Legg-Calve-Perthes disease. Part I: Classification of radiographs with use of the modified lateral pillar and Stulberg classifications. (15466719)
2004
28
Legg-Calve-Perthes disease and thrombophilia. (15590848)
2004
29
Treatment of the collapsed femoral head by containment in Legg-Calve-Perthes disease. (12499936)
2003
30
The 1226G (N370S) Gaucher mutation among patients with Legg-Calve-Perthes disease. (12850487)
2003
31
Avascular necrosis of the femoral heads in a red panda (Ailurus fulgens fulgens): possible Legg-Calve-Perthes disease. (12462497)
2002
32
Legg-Calve-Perthes Disease: Imaging Evaluation and Management. (11388931)
1999
33
Growth profiles and articular cartilage characterization in a goat model of Legg-Calve-Perthes disease. (8751151)
1995
34
Surgical treatment of Legg-Calve-Perthes disease. (1345635)
1992
35
Legg-Calve-Perthes disease and slipping of the capital femoral epiphysis in the same child. (1437868)
1992
36
Modified epiphyseal index for MRI in Legg-Calve-Perthes disease (LCPD). (2047161)
1991
37
Legg-Calve-Perthes disease: clinical analysis of 57 cases. (1982536)
1990
38
An instrumented brace for study of Legg-Calve-Perthes disease. (3452429)
1987-1988
39
Legg-Calve-Perthes disease following transient synovitis. How often? (4053478)
1985
40
Three-dimensional finite element analysis of Legg-Calve-Perthes disease. (7076833)
1982
41
Osteochondritis dissecans in association with Legg-Calve-Perthes disease. (528085)
1979
42
Alternative treatments in Legg-Calve-Perthes disease. (268224)
1977
43
Legg-Calve-Perthes disease: a statistical evaluation of 358 cases. (4539905)
1973
44
Minimal Legg-Calve-Perthes disease. (5241837)
1968
45
Legg-Calve-Perthes disease: clinical-radiographic correlations. (5832723)
1965
46
Hereditary Legg-Calve-Perthes disease. (13998760)
1963
47
Osteochondritis dissecans following Legg-Calve-Perthes disease. A report of one case. (13849850)
1960
48
Legg-Calve-Perthes disease. (13807159)
1960
49
The deformity in Legg-Calve-Perthes disease. (13716060)
1960
50
Osteochondrosis of capital epiphysis of femur (Legg-Calve-Perthes disease); long-term end-results in ninety patients. (13807871)
1960

Genetic Variations for Legg-Calve-Perthes Disease

Expression for genes affiliated with Legg-Calve-Perthes Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Legg-Calve-Perthes Disease

Search GEO for disease gene expression data for Legg-Calve-Perthes Disease.

Pathways for genes affiliated with Legg-Calve-Perthes Disease

Sources:
54Reactome, 52QIAGEN, 53R&D Systems, 38NCBI BioSystems Database, 30KEGG
See all sources

Compounds for genes affiliated with Legg-Calve-Perthes Disease

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 2BitterDB, 60Tocris Bioscience, 29IUPHAR
See all sources

Compounds related to Legg-Calve-Perthes Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 68)
idCompoundScoreTop Affiliating Genes
1warfarin45 50 11 2413.5SERPINC1
2sarpogrelate hydrochloride4510.3THBD, SERPINC1
3inogatran4510.3SERPINC1, F5
4fibrinopeptide a4510.3SERPINC1, THBD
5ecarin4510.2F5, SERPINC1
6spectrozyme4510.2SERPINC1, F5
7danaparoid4510.2F5, SERPINC1
8nafamostat mesilate4510.2SERPINC1, F5
9eaca4510.1SERPINC1, SERPINE1
10batroxobin4510.1F5, SERPINE1
11paricalcitol45 1111.1THBD, SERPINE1
12eltrombopag50 1111.1SERPINC1, F5
13p-amino benzamidine4510.1SERPINE1, SERPINC1
14hirugen4510.1THBD, SERPINC1, F5
15ximelagatran45 1111.1SERPINC1, THBD, F5
16heparinoids4510.1SERPINC1, THBD, F5
17fondaparinux4510.1SERPINC1, THBD, F5
18bivalirudin45 1111.1THBD, F5, SERPINC1
19argatroban45 1111.1F5, THBD, SERPINC1
20benzamidine45 1111.0THBD, F5, SERPINC1
21desogestrel45 1111.0SERPINC1, F5
22dermatan sulfate4510.0THBD, SERPINC1, F5
2311-dehydrothromboxane b24510.0SERPINE1, THBD
24Drotrecogin alfa1110.0F5, THBD, SERPINE1
25mycophenolate mofetil45 50 1112.0THBD, F5, SERPINE1
26ulinastatin4510.0THBD, SERPINC1
27tibolone459.9SERPINC1, SERPINE1, F5
28protamine459.9SERPINE1, SERPINC1, F5
29gabexate mesilate459.9SERPINC1, F5
30polyethylene glycol459.8THBD, SERPINC1, F5
31pge1459.8THBD, F5, SERPINE1
32glycosaminoglycan459.8THBD, COL2A1, SERPINC1
33protamine sulfate459.8F5, SERPINC1
34chloramphenicol45 2 1111.7COL2A1, SERPINE1, SERPINC1, THBD
35ancrod459.7F5, THBD, SERPINE1, SERPINC1
36desmopressin45 60 29 1112.7SERPINC1, SERPINE1, THBD, F5
37hirudin459.7SERPINC1, F5, SERPINE1, THBD
38ibuprofen45 29 50 11 2413.7COL2A1, AKR1C1, THBD
39kininogen459.7THBD, SERPINE1, SERPINC1, F5
40aprotinin45 1110.7THBD, F5, SERPINE1, SERPINC1
41homocysteine45 2410.7SERPINC1, F5, SERPINE1, THBD
42prostacyclin459.7SERPINE1, THBD, F5, SERPINC1
43ascorbic acid45 2410.7COL2A1, SERPINC1, THBD, F5
44fibrinogen459.5SERPINC1, SERPINE1, THBD, F5
45raloxifene45 29 50 1112.5PEPD, SERPINC1, F5, THBD, SERPINE1
46aspirin45 50 29 2412.5PEPD, F5, THBD, SERPINE1, SERPINC1
47creatinine459.4SERPINC1, THBD, PEPD, F5, SERPINE1
48progestin459.3AKR1C1, F5, SERPINE1, SERPINC1
49atorvastatin45 50 29 11 2413.3SERPINE1, THBD, F5
50estrogen458.8F5, PEPD, SERPINC1, AKR1C1, THBD, SERPINE1

GO Terms for genes affiliated with Legg-Calve-Perthes Disease

Sources:
16Gene Ontology
See all sources

Biological processes related to Legg-Calve-Perthes Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of fibrinolysisGO:0519189.8SERPINE1, THBD
2negative regulation of blood coagulationGO:0301959.6SERPINE1, THBD
3blood coagulationGO:0075969.3SERPINC1, SERPINE1, THBD, F5

Molecular functions related to Legg-Calve-Perthes Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055156.4SERPINC1, PHIP, STAG2, F5, RAB3IL1, THBD

Products for genes affiliated with Legg-Calve-Perthes Disease

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  • Proteins
  • Lysates
  • Antibodies

Sources for Legg-Calve-Perthes Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet