LCPD
MCID: LGG001
MIFTS: 61

Legg-Calve-Perthes Disease (LCPD) malady

Bone diseases category

Summaries for Legg-Calve-Perthes Disease

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Legg-calve-perthes disease occurs when the ball of the thighbone in the hip doesn’t get enough blood, causing the bone to die. early symptoms may include mildly painful limp, pain down the inner thigh to the knee, some restriction of hip movement, pain at extremes of movement, and tenderness over the hip joint. treatment may include a brief period of bed rest (1 to 3 days) followed by bracing. rarely bracing may be required for 2 to 3 years. chance of recovery (prognosis) varies, but tends to be better for younger patients (e.g., less than 6 years of age). some people with this syndrome go on to develop degenerative arthritis. the cause of the condition is unknown. last updated: 1/6/2011

MalaCards: Legg-Calve-Perthes Disease, also known as perthes disease, is related to collagen disease and vascular disease, and has symptoms including short stature/dwarfism/nanism, polygenic/multifactorial inheritance and cartilage destruction/chondrolysis. An important gene associated with Legg-Calve-Perthes Disease is COL2A1 (collagen, type II, alpha 1), and among its related pathways are Common Pathway and Platelet activation, signaling and aggregation. The compounds warfarin and sarpogrelate hydrochloride have been mentioned in the context of this disorder. Affiliated tissues include hip joint and bone, and related mouse phenotype liver/biliary system.

Disease Ontology:8 An osteochondrosis that results in death and fracture located in hip joint.

Description from OMIM:46 150600

Aliases & Classifications for Legg-Calve-Perthes Disease

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Sources:
60UMLS, 8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 22GTR, 56SNOMED-CT, 39NCIt, 34MeSH, 26ICD10 via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Characteristics (Orphanet epidemiological data):

48
perthes disease:
Inheritance: Autosomal dominant,Multigenic/multifactorial; Age of onset: Childhood; Age of death: Normal


Aliases & Descriptions:

legg-calve-perthes disease 8 9 42 46 10 60
perthes disease 8 42 44 48
coxa plana 8 42 22
avascular necrosis of the capital femoral epiphysis 60
aseptic necrosis of the capital femoral epiphysis 48
osteochondrosis of the capital femoral epiphysis 48
osteochondritis of the capital femoral epiphysis 48
juvenile osteochondrosis of hip and/or pelvis 8
juvenile osteochondrosis of tibial tubercle 60
juvenile osteochondrosis of hip and pelvis 8
osteochondrosis of legg-calve-perthes 8
juvenile osteochond-hip/pelvis 8
legg-calvé-perthes disease 48
legg-calve-perthes syndrome 42
osteochondritis deformans 42
calve - perthes' disease 8
perthe's disease 8
pseudocoxalgia 8
lcpd 42


External Ids:

Disease Ontology8 DOID:14415
NCIt39 C34766
OMIM46 150600
MeSH34 D007873
ICD10 via Orphanet26 M91.1
ICD1025 M91, M91.2, M91.3

Related Diseases for Legg-Calve-Perthes Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Legg-Calve-Perthes Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 301)
idRelated DiseaseScoreTop Affiliating Genes
1collagen disease30.6THBD, COL2A1
2vascular disease30.6SERPINC1, THBD
3thrombophilia30.5F5, SERPINC1, THBD, SERPINE1
4protein c deficiency30.5SERPINE1, THBD, F5, SERPINC1
5protein s deficiency29.9SERPINE1, F5, SERPINC1
6osteochondritis dissecans10.6
7osgood-schlatter's disease10.6
8upington disease10.5
9kienbock's disease10.4
10osteochondritis of tarsal/metatarsal bone10.4
11thiemann disease, familial form10.4
12panner disease10.4
13sinding-larsen-johansson disease10.4
14cartilage disease10.4
15exostosis10.4
16osteochondrosis10.4
17synovitis10.4
18multiple epiphyseal dysplasia10.3
19type vi ehlers-danlos syndrome10.2
20achondroplasia10.1
21osteoarthritis10.1
22thyroiditis10.1
23diastrophic dysplasia10.1
24thrombocytopenia-absent radius syndrome10.1
25smith-lemli-opitz syndrome10.1
26rothmund-thomson syndrome10.1
27rubinstein-taybi syndrome10.1
28coffin-siris syndrome10.1
29cutis laxa10.1
30cartilage-hair hypoplasia10.1
31trichorhinophalangeal syndrome type i10.1
32weaver syndrome10.1
33mucopolysaccharidosis iv10.1
34sly syndrome10.1
35mucopolysaccharidosis iii10.1
36mucopolysaccharidosis ii10.1
37trichorhinophalangeal syndrome type ii10.1
38camurati-engelmann disease10.1
39campomelic dysplasia10.1
40spondyloepimetaphyseal dysplasia, sponastrime type10.1
41borjeson-forssman-lehmann syndrome10.1
42arterial tortuosity syndrome10.1
43distal arthrogryposis10.1
44edwards syndrome10.1
45oculocerebrorenal syndrome10.1
46aicardi syndrome10.1
47infectious mononucleosis10.1
48acrocapitofemoral dysplasia10.1
49kniest dysplasia10.1
50spondyloepimetaphyseal dysplasia, missouri type10.1

Graphical network of the top 20 diseases related to Legg-Calve-Perthes Disease:



Diseases related to legg-calve-perthes disease

Clinical Features for Legg-Calve-Perthes Disease

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Sources:
46OMIM, 48Orphanet
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Clinical features from OMIM:

150600

Clinical synopsis from OMIM:

150600

Symptoms:

48 (show all 9)
  • short stature/dwarfism/nanism
  • polygenic/multifactorial inheritance
  • cartilage destruction/chondrolysis
  • joint/articular deformation
  • articular/joint pain/arthralgia
  • osteonecrosis/bone infarction
  • delayed bone age
  • muscle hypotrophy/atrophy/dystrophy/agenesis/amyotrophy
  • abnormal dentition/dental position/implantation/unerupted/dental ankylosis

Drugs & Therapeutics for Legg-Calve-Perthes Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Legg-Calve-Perthes Disease

Drug clinical trials:

Search ClinicalTrials for Legg-Calve-Perthes Disease

Search NIH Clinical Center for Legg-Calve-Perthes Disease

Search CenterWatch for Legg-Calve-Perthes Disease

Genetic Tests for Legg-Calve-Perthes Disease

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22GTR
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Genetic tests related to Legg-Calve-Perthes Disease:

id Genetic test Affiliating Genes
1 Coxa Plana22

Anatomical Context for Legg-Calve-Perthes Disease

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Legg-Calve-Perthes Disease:

32
Bone

FMA organs/tissues related to Legg-Calve-Perthes Disease:

14
Hip joint

Animal Models for Legg-Calve-Perthes Disease or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Legg-Calve-Perthes Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.8SERPINC1, SERPINE1, THBD, F5, PHIP, COL2A1

Publications for Legg-Calve-Perthes Disease

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Sources:
50PubMed
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Articles related to Legg-Calve-Perthes Disease:

(show top 50)    (show all 83)
idTitleAuthorsYear
1
Local delivery of recombinant human bone morphogenetic proteins and bisphosphonate via sucrose acetate isobutyrate can prevent femoral head collapse in Legg-Calve-Perthes disease: a pilot study in pigs. (24389948)
2014
2
Diffusion MRI of the neck of the femur in Legg-Calve-Perthes disease: a preliminary study. (23206418)
2013
3
MR perfusion index as a quantitative method of evaluating epiphyseal perfusion in Legg-Calve-Perthes disease and correlation with short-term radiographic outcome: a preliminary study. (23872796)
2013
4
Legg-Calve-Perthes disease in two generations of male family members: a case report. (24014797)
2013
5
Combined osteotomy in patients with severe Legg-Calve-Perthes disease. (23451451)
2012
6
Prognosis and prognostic factors of Legg-Calve-Perthes disease. (21857429)
2011
7
Legg-Calve-Perthes disease: etiology, pathogenesis, and biology. (21857428)
2011
8
Transtrochanteric rotational osteotomy for late-onset Legg-Calve-Perthes disease. (21857443)
2011
9
Legg-Calve-Perthes disease in a patient with Albright hereditary osteodystrophy: a case report. (20124073)
2010
10
Varus producing osteotomy for patients with lateral pillar type B and C Legg-Calve-Perthes disease followed to skeletal maturity. Castaneda et al. JCOR (2008), 2:373-379. (19308615)
2009
11
Coxa magna quantification using MRI in Legg-Calve-Perthes disease. (18992975)
2009
12
Systemic effects of zoledronic acid in children with traumatic femoral head avascular necrosis and Legg-Calve-Perthes disease. (19446052)
2009
13
Conservative versus surgical treatment of late-onset Legg-Calve-Perthes disease: a radiographic comparison at skeletal maturity. (19308608)
2009
14
Thrombomodulin and GFC levels in Legg-Calve-Perthes disease. (19055859)
2008
15
Sagittal spinal alignment in patients with Legg-Calve-Perthes disease. (17875086)
2007
16
Legg-calve-perthes disease: a review of cases with onset before six years of age. (18056504)
2007
17
A recurrent mutation in type II collagen gene causes Legg-Calve- Perthes disease in a Japanese family. (17394019)
2007
18
Legg-Calve-Perthes disease, venous and arterial thrombi, and the factor V Leiden mutation in a four-generation kindred. (17878795)
2007
19
Outcome of cheilectomy in Legg-Calve-Perthes disease: minimum 25-year follow-up of five patients. (16557136)
2006
20
Protein C levels in patients with Legg-Calve-Perthes disease: is it a true deficiency? (16557135)
2006
21
Residual shortening after Legg-Calve-Perthes disease, focusing on the response of the ipsilateral tibia. (15832141)
2005
22
Enhanced tissue factor pathway inhibitor response as a defense mechanism against ongoing local microvascular events of Legg-Calve-Perthes disease. (16020129)
2005
23
Usefulness of epiphyseal quotient measurement on magnetic resonance images for outcome prediction in patients with early-stage Legg-Calve-Perthes disease. (15577302)
2005
24
Arthroscopic findings of the hip in new onset hip pain in adolescents with previous Legg-Calve-Perthes disease. (15812283)
2005
25
Legg-Calve-Perthes disease. Part I: Classification of radiographs with use of the modified lateral pillar and Stulberg classifications. (15466719)
2004
26
Legg-Calve-Perthes disease and thrombophilia. (15590848)
2004
27
Treatment of the collapsed femoral head by containment in Legg-Calve-Perthes disease. (12499936)
2003
28
The 1226G (N370S) Gaucher mutation among patients with Legg-Calve-Perthes disease. (12850487)
2003
29
Fate of the osteochondral fragments in osteochondritis dissecans after Legg-Calve-Perthes' disease. (12358366)
2002
30
Legg-Calve-Perthes Disease: Imaging Evaluation and Management. (11388931)
1999
31
Ultrasonographic evaluation of Legg-Calve-Perthes disease based on sonoanatomic criteria and the application of new measuring techniques. (1425742)
1992
32
Surgical treatment of Legg-Calve-Perthes disease. (1345635)
1992
33
Modified epiphyseal index for MRI in Legg-Calve-Perthes disease (LCPD). (2047161)
1991
34
Legg-Calve-Perthes disease: clinical analysis of 57 cases. (1982536)
1990
35
An instrumented brace for study of Legg-Calve-Perthes disease. (3452429)
1987-1988
36
Three-dimensional finite element analysis of Legg-Calve-Perthes disease. (7076833)
1982
37
Osteochondritis dissecans in association with Legg-Calve-Perthes disease. (528085)
1979
38
Legg-Calve-Perthes disease associated with hereditary multiple exostosis: a case report. (306501)
1978
39
A study of the radiographic and histological changes occurring in Legg-Calve-Perthes disease (LCP) in the dog. (5531150)
1970
40
Minimal Legg-Calve-Perthes disease. (5241837)
1968
41
Developmental variation in epiphyseogenesis of the femoral head on the unaffected hip in unilateral Legg-Calve-Perthes disease. (5247151)
1968
42
Legg-Calve-Perthes disease: clinical-radiographic correlations. (5832723)
1965
43
Hereditary Legg-Calve-Perthes disease. (13998760)
1963
44
Experimental production in the rabbit of coxa plana: a lesion resembling Legg-Calve-Perthes disease in man. (13950195)
1963
45
Legg-Calve-Perthes disease: the roentgenologic changes with therapy in forty patients. (14486234)
1962
46
Osteochondritis dissecans following Legg-Calve-Perthes disease. A report of one case. (13849850)
1960
47
Legg-Calve-Perthes disease. (13807159)
1960
48
The deformity in Legg-Calve-Perthes disease. (13716060)
1960
49
New Treatment for Bilateral Legg-Calve-Perthes Disease. (20326173)
1960
50
Osteochondrosis of capital epiphysis of femur (Legg-Calve-Perthes disease); long-term end-results in ninety patients. (13807871)
1960

Genetic Variations for Legg-Calve-Perthes Disease

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Expression for genes affiliated with Legg-Calve-Perthes Disease

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Legg-Calve-Perthes Disease

Search GEO for disease gene expression data for Legg-Calve-Perthes Disease.

Pathways for genes affiliated with Legg-Calve-Perthes Disease

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Sources:
53Reactome, 51QIAGEN, 52R&D Systems, 37NCBI BioSystems Database, 29KEGG
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Compounds for genes affiliated with Legg-Calve-Perthes Disease

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 2BitterDB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Legg-Calve-Perthes Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 68)
idCompoundScoreTop Affiliating Genes
1warfarin44 49 11 2413.5SERPINC1
2sarpogrelate hydrochloride4410.3THBD, SERPINC1
3inogatran4410.3SERPINC1, F5
4fibrinopeptide a4410.3SERPINC1, THBD
5ecarin4410.2F5, SERPINC1
6spectrozyme4410.2SERPINC1, F5
7danaparoid4410.2F5, SERPINC1
8nafamostat mesilate4410.2SERPINC1, F5
9eaca4410.1SERPINC1, SERPINE1
10batroxobin4410.1F5, SERPINE1
11paricalcitol44 1111.1THBD, SERPINE1
12eltrombopag49 1111.1SERPINC1, F5
13p-amino benzamidine4410.1SERPINE1, SERPINC1
14hirugen4410.1THBD, SERPINC1, F5
15ximelagatran44 1111.1SERPINC1, THBD, F5
16heparinoids4410.1SERPINC1, THBD, F5
17fondaparinux4410.1SERPINC1, THBD, F5
18bivalirudin44 1111.1THBD, F5, SERPINC1
19argatroban44 1111.1F5, THBD, SERPINC1
20benzamidine44 1111.0THBD, F5, SERPINC1
21desogestrel44 1111.0SERPINC1, F5
22dermatan sulfate4410.0THBD, SERPINC1, F5
2311-dehydrothromboxane b24410.0SERPINE1, THBD
24Drotrecogin alfa1110.0F5, THBD, SERPINE1
25mycophenolate mofetil44 49 1112.0THBD, F5, SERPINE1
26ulinastatin4410.0THBD, SERPINC1
27tibolone449.9SERPINC1, SERPINE1, F5
28protamine449.9SERPINE1, SERPINC1, F5
29gabexate mesilate449.9SERPINC1, F5
30polyethylene glycol449.8THBD, SERPINC1, F5
31pge1449.8THBD, F5, SERPINE1
32glycosaminoglycan449.8THBD, COL2A1, SERPINC1
33protamine sulfate449.8F5, SERPINC1
34chloramphenicol44 2 1111.7COL2A1, SERPINE1, SERPINC1, THBD
35ancrod449.7F5, THBD, SERPINE1, SERPINC1
36desmopressin44 59 28 1112.7SERPINC1, SERPINE1, THBD, F5
37hirudin449.7SERPINC1, F5, SERPINE1, THBD
38ibuprofen44 28 49 11 2413.7COL2A1, AKR1C1, THBD
39kininogen449.7THBD, SERPINE1, SERPINC1, F5
40aprotinin44 1110.7THBD, F5, SERPINE1, SERPINC1
41homocysteine44 2410.7SERPINC1, F5, SERPINE1, THBD
42prostacyclin449.7SERPINE1, THBD, F5, SERPINC1
43ascorbic acid44 2410.7COL2A1, SERPINC1, THBD, F5
44fibrinogen449.5SERPINC1, SERPINE1, THBD, F5
45raloxifene44 28 49 1112.5PEPD, SERPINC1, F5, THBD, SERPINE1
46aspirin44 49 28 2412.5PEPD, F5, THBD, SERPINE1, SERPINC1
47creatinine449.4SERPINC1, THBD, PEPD, F5, SERPINE1
48progestin449.3AKR1C1, F5, SERPINE1, SERPINC1
49atorvastatin44 49 28 11 2413.3SERPINE1, THBD, F5
50estrogen448.8F5, PEPD, SERPINC1, AKR1C1, THBD, SERPINE1

GO Terms for genes affiliated with Legg-Calve-Perthes Disease

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16Gene Ontology
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Biological processes related to Legg-Calve-Perthes Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of fibrinolysisGO:0519189.8SERPINE1, THBD
2negative regulation of blood coagulationGO:0301959.6SERPINE1, THBD
3blood coagulationGO:0075969.3SERPINC1, SERPINE1, THBD, F5

Molecular functions related to Legg-Calve-Perthes Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055156.4SERPINC1, PHIP, STAG2, F5, RAB3IL1, THBD

Products for genes affiliated with Legg-Calve-Perthes Disease

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  • Antibodies
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Sources for Legg-Calve-Perthes Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet