MCID: LGG001
MIFTS: 58

Legg-Calve-Perthes Disease malady

Categories: Genetic diseases, Rare diseases, Bone diseases

Aliases & Classifications for Legg-Calve-Perthes Disease

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Sources:
50OMIM, 11Disease Ontology, 46NIH Rare Diseases, 24Genetics Home Reference, 13DISEASES, 52Orphanet, 68UniProtKB/Swiss-Prot, 25GTR, 12diseasecard, 48Novoseek, 37MeSH, 66UMLS, 28ICD10, 43NCIt, 29ICD10 via Orphanet, 67UMLS via Orphanet, 35MedGen, 60SNOMED-CT
See all MalaCards sources

Aliases & Descriptions for Legg-Calve-Perthes Disease:

Name: Legg-Calve-Perthes Disease 50 11 46 13 68 12 37 66
Perthes Disease 11 46 24 52 68 48
Coxa Plana 11 46 25
Lcpd 46 24 68
Legg-Calvé-Perthes Disease 24 52
Avascular Necrosis of the Capital Femoral Epiphysis 66
Aseptic Necrosis of the Capital Femoral Epiphysis 52
Osteochondrosis of the Capital Femoral Epiphysis 52
Osteochondritis of the Capital Femoral Epiphysis 52
Juvenile Osteochondrosis of Hip and/or Pelvis 11
Juvenile Osteochondrosis of Hip and Pelvis 11
 
Osteochondrosis of Legg-Calve-Perthes 11
Juvenile Osteochond-Hip/pelvis 11
Legg-Calve-Perthes Syndrome 46
Legg-Calve-Perthes Symptom 11
Osteochondritis Deformans 46
Calve - Perthes' Disease 11
Calve-Perthes Disease 24
Legg-Perthes Disease 68
Perthe's Disease 11
Pseudocoxalgia 11

Characteristics:

Orphanet epidemiological data:

52
perthes disease:
Inheritance: Autosomal dominant,Multigenic/multifactorial; Age of onset: Childhood; Age of death: normal life expectancy

Classifications:



External Ids:

OMIM50 150600
Disease Ontology11 DOID:14415
ICD1028 M91.2, M91.3, M91
MeSH37 D007873
NCIt43 C34766
Orphanet52 ORPHA2380
ICD10 via Orphanet29 M91.1
UMLS via Orphanet67 C0023234
MedGen35 C0023234

Summaries for Legg-Calve-Perthes Disease

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NIH Rare Diseases:46 Legg-calve-perthes disease (lcpd) occurs when blood supply to the ball of the thighbone in the hip (femoral head) is disrupted. without an adequate blood supply, the bone cells die. lcpd usually occurs in children between the ages of 4 and 10. early symptoms may include limping; pain in the hip, thigh or knee; and reduced range of hip motion. later in the disease course, there may be leg length discrepancy (one leg longer than the other) and wasting of the muscles around the hip. the condition can last for several years before new bone formation (re-ossification) and eventual healing occurs. some people with lcpd go on to develop degenerative arthritis in adulthood. the underlying cause of lcpd is often not known. sometimes it results from a slipped capital femoral epiphysis, trauma, steroid use, sickle-cell crisis, toxic synovitis, or congenital hip dysplasia. it usually is not caused by genetic factors, but a few familial cases with autosomal dominant inheritance have been reported. in a small percentage of cases, mutations in the col2a1 gene were found to be responsible. treatment aims to keep the thigh bone inside the hip socket. treatment options may include rest or medication for pain; physical therapy; using a brace; or surgery. last updated: 7/28/2016

MalaCards based summary: Legg-Calve-Perthes Disease, also known as perthes disease, is related to garret tripp syndrome and upington disease, and has symptoms including abnormality of the teeth, delayed skeletal maturation and arthralgia. An important gene associated with Legg-Calve-Perthes Disease is COL2A1 (Collagen Type II Alpha 1 Chain), and among its related pathways are Cell adhesion_ECM remodeling and T Cell Co-Signaling Pathway: Ligand-Receptor Interactions. Affiliated tissues include hip joint, bone and skeletal muscle, and related mouse phenotypes are respiratory system and liver/biliary system.

Disease Ontology:11 An osteochondrosis that results in death and fracture located in hip joint.

UniProtKB/Swiss-Prot:68 Legg-Calve-Perthes disease: Characterized by loss of circulation to the femoral head, resulting in avascular necrosis in a growing child. Clinical pictures of the disease vary, depending on the phase of disease progression through ischemia, revascularization, fracture and collapse, and repair and remodeling of the bone.

Genetics Home Reference:24 Legg-Calvé-Perthes disease is a bone disorder that affects the hips. Usually, only one hip is involved, but in about 10 percent of cases, both hips are affected. Legg-Calvé-Perthes disease begins in childhood, typically between ages 4 and 8, and affects boys more frequently than girls.

OMIM:50 Legg-Calve-Perthes disease is characterized by loss of circulation to the femoral head, resulting in avascular necrosis... (150600) more...

Related Diseases for Legg-Calve-Perthes Disease

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Diseases related to Legg-Calve-Perthes Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 98)
idRelated DiseaseScoreTop Affiliating Genes
1garret tripp syndrome11.0
2upington disease10.6
3osteochondritis dissecans10.5
4lymphatic system cancer10.4SERPINC1, THBD
5diphyllobothriasis10.4CD40LG, SERPINC1
6laryngeal cartilage cancer10.4CD40LG, COL2A1
7marek disease10.4CD40LG, SERPINC1
8hepatic fibrosis renal cysts mental retardation10.4CD40LG, SERPINC1
9venezuelan hemorrhagic fever10.4SERPINC1, SERPINE1
10collagenous colitis10.4SERPINC1, SERPINE1
11hypertensive heart disease10.4SERPINC1, SERPINE1
12rocky mountain spotted fever10.4CD40LG, SERPINC1
13angular blepharoconjunctivitis10.4SERPINC1, THBD
14lateral cystocele10.4SERPINC1, SERPINE1
15prostatic hypertrophy10.4CD40LG, SERPINC1
16polyhydramnios10.4SERPINC1, SERPINE1
17functional colonic disease10.3SERPINC1, SERPINE1
18pseudohermaphroditism10.3SERPINC1, THBD
19lujo hemorrhagic fever10.3CD40LG, SERPINC1
20intracranial arteriosclerosis10.3CD40LG, SERPINC1
21bone resorption disease10.3COL2A1, SERPINE1
22facial hemiatrophy10.3SELP, SERPINC1
23multiple epiphyseal dysplasia10.3
24unicentric castleman disease10.3CD40LG, SERPINE1
25avascular necrosis of the femoral head10.3
26arthritis10.3
27osteochondrosis10.3
28osteonecrosis10.3
29exostosis10.3
30thrombophilia10.3
31synovitis10.3
32hypopituitarism10.3
33pandas10.3
34histoplasmosis10.2SELP, SERPINC1
35sacrococcygeal teratoma10.2SERPINC1, SERPINE1
36catatrichy10.2CD40LG, SERPINE1
37chronic apical periodontitis10.2CD40LG, SERPINC1
38exophthalmic ophthalmoplegia10.2SERPINC1, SERPINE1
39colon carcinoma in situ10.2SELP, SERPINC1
40cervical mullerian papilloma10.2SERPINC1, SERPINE1
41bacteriuria10.2CD40LG, SERPINC1
42retinal dystrophy, iris coloboma, and comedogenic acne syndrome10.1SELP, SERPINE1
43ovarian insufficiency, familial10.1COL2A1, SERPINC1, SERPINE1
44atrophic gastritis10.1CD40LG, SELP
45oppositional defiant disorder10.1SELP, SERPINE1
46xanthomatosis10.0CD40LG, COL2A1
47tuberculoid leprosy10.0CD40LG, SELP
48focal epilepsy10.0SELP, SERPINC1
49frontal sinus cancer10.0SERPINC1, THBD
50tollner horst manzke syndrome10.0SERPINC1, SERPINE1, THBD

Graphical network of the top 20 diseases related to Legg-Calve-Perthes Disease:



Diseases related to legg-calve-perthes disease

Symptoms for Legg-Calve-Perthes Disease

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Symptoms by clinical synopsis from OMIM:

150600

Clinical features from OMIM:

150600

Symptoms:

 52 (show all 8)
  • abnormality of the teeth
  • joint dislocation
  • delayed skeletal maturation
  • arthralgia
  • skeletal muscle atrophy
  • short stature
  • aseptic necrosis
  • cartilage destruction

HPO human phenotypes related to Legg-Calve-Perthes Disease:

(show all 9)
id Description Frequency HPO Source Accession
1 abnormality of the teeth hallmark (90%) HP:0000164
2 delayed skeletal maturation hallmark (90%) HP:0002750
3 arthralgia hallmark (90%) HP:0002829
4 skeletal muscle atrophy hallmark (90%) HP:0003202
5 short stature hallmark (90%) HP:0004322
6 cartilage destruction hallmark (90%) HP:0100773
7 delayed skeletal maturation HP:0002750
8 short stature HP:0004322
9 avascular necrosis of the capital femoral epiphysis HP:0005743

Drugs & Therapeutics for Legg-Calve-Perthes Disease

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Drugs for Legg-Calve-Perthes Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Triamcinolone463124-94-731307
Synonyms:
(8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
11-beta,16-alpha,17-alpha,21-Tetrahydroxy-9-alpha-fluoro-1,4-pregnadiene-3,20-dione
11.Beta.,16.alpha.,17.alpha., 21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione
11.beta.,16.alpha.,17.alpha.,21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione
11β,16α,17α,21-tetrahydroxy-9α-fluoro-1,4-pregnadiene-3,20-dione
124-94-7
4-08-00-03629 (Beilstein Handbook Reference)
83474-03-7
9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-alpha-Fluoro-11-beta,16-alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-alpha-Fluoro-16-alpha-hydroxyprednisolone
9-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9.Alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahy
9.Alpha.-Fluoro-11.beta.,16.alpha.,17.alpha., 21-tetrahydroxypregna-1,4-diene-3,20-d
9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione
9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9.alpha.-Fluoro-11.beta.,16.alpha.,17.alpha.,21-tetrahydroxypregna-1,4-diene-3,20-dione
9.alpha.-Fluoro-16.alpha.-hydroxyprednisolone
9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione
9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9alpha-Fluoro-16alpha-hydroxyprednisolone
9α-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9α-fluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione
9α-fluoro-16α-hydroxyprednisolone
AC-2072
AC1L1LDH
AC1Q5HJC
Adcortyl
Aristocort
Aristocort A
Aristocort Tablets
Aristogel
Aristospan
Azmacort
BPBio1_000154
BRD-K77554836-001-03-3
BRN 2341955
BSPBio_000140
Bio-0662
C21H27FO6
CHEMBL1451
CID31307
CL 19823
Celeste
Cinolone
Cinolone-T
D00385
D014221
DB00620
Delphicort
EINECS 204-718-7
EU-0101179
Fluoxiprednisolone
Fluoxyprednisolone
Flutex
Fougera
HMS1568G22
HMS2090D12
HSDB 3194
Kenacort
Kenacort (TN)
Kenacort-A
Kenacort-AG
Kenacort-Ag
Kenalog
Kenalog in Orabase
Kenalog-10
Kenalog-40
Kenalog-H
LS-698
Ledercort
Lopac0_001179
 
MLS000028542
MLS001066543
MLS002695935
MolPort-002-528-981
Mycolog
NCGC00021580-03
NCGC00021580-04
NCGC00021580-05
NCGC00021580-06
NCGC00021580-07
NCI60_000750
NSC 13397
NSC13397
Nasacort
Nasacort Aq
Nasacort Hfa
Omcilon
Omicilon
Oracort
Oralone
Orion
Polcortolon
Pregna-1,4-diene-3,20-dio
Pregna-1,4-diene-3,20-dione, 9-fluoro-11,16,17,21-tetrahydroxy-, (11beta,16alpha)
Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,16alpha,17,21-tetrahydroxy- (8CI)
Prestwick0_000120
Prestwick1_000120
Prestwick2_000120
Prestwick3_000120
Prestwick_438
Rodinolone
S1933_Selleck
SK-Triamcinolone
SMP1_000300
SMR000058333
SPBio_002079
Sk-Triamcinolone
T6376_SIGMA
TRIAMCINOLONE (SEE ALSO TRIAMCINOLONE ACETONIDE (76-25-5) AND TRIAMCINOLONE DIACETATE (67-78-7))
Tiamcinolonum
Tiamcinolonum [INN-Latin]
Tri-Nasal
Triacet
Triacort
Triam-Tablinen
Triamcet
Triamcinalone
Triamcinlon
Triamcinolon
Triamcinolona
Triamcinolona [INN-Spanish]
Triamcinolone (JP15/USP/INN)
Triamcinolone [USAN:INN:BAN:JAN]
Triamcinolone acetonide
Triamcinolone diacetate
Triamcinolone hexacetonide
Triamcinolonum
Triamcinolonum [INN]
Triatex
Tricortale
Triderm
Trilone
Tristoject
Trymex
UNII-1ZK20VI6TY
Vetalog
Volon
Volon A
WLN: L E5 B666 OV KU MUTJ A1 BF CQ E1 FV1Q FQ GQ
ZINC03882036
droxypregna-1,4-diene-3,20-dione
ione
nchembio.2007.53-comp7
triamcinolone
2triamcinolone acetonide463
3glucocorticoids4756
4
vitamin eNutraceutical39259-02-914985
Synonyms:
(+)-a-Tocopherol
(+)-alpha-Tocopherol
(+)-α-tocopherol
(2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-TRIMETHYLTRIDECYL]CHROMAN-6-OL
(2R)-3,4-Dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-ol
(2R,4'R,8'R)-a-Tocopherol
(2R,4'R,8'R)-alpha-Tocopherol
(2R,4'R,8'R)-α-tocopherol
(R,R,R)-a-Tocopherol
(R,R,R)-alpha-Tocopherol
(R,R,R)-α-tocopherol
5,7,8-Trimethyltocol
5,7,8-trimethyltocol
Amino-Opti-E
Aquasol E
D-alpha-Tocopherol
Daltose
Denamone
E-200 I.U. Softgels
 
E-Complex-600
E-Ferol
E-Vitamin succinate
Eprolin
Gordo-Vite E
Phytogermin
Phytogermine
RRR-alpha-tocopherol
RRR-alpha-tocopheryl
Tocopherol
Vitamin E
Vitamin Ea
Vitamin Plus E Softgells
Vitec
a-D-Tocopherol
a-Tocopherol
alpha-Tocopherol
alpha-delta-Tocopherol
alpha-tocopherol
d-α-tocopherol
delta-alpha-Tocopherol
5TocotrienolNutraceutical391
6TocopherolNutraceutical395

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Randomised Multi-centre Study to Compare the Long-term Performance of the Future Hip to 3 Other Implants in Primary Total Hip ReplacementTerminatedNCT00208468Phase 3
2The Long Term Outcome of Varus Derotational Osteotomy for Legg-Calvé-Perthes' DiseaseCompletedNCT02676271
3Taperloc Complete Microplasty vs Taperloc Complete Standard: Randomized Controlled Study on Bone Mineral DensityCompletedNCT02087436
4Diagnosis of Mucopolysaccharidosis Disorders in Patients Presenting With Bilateral Hip DiseaseCompletedNCT01707433
5Multicenter Prospective Cohort Study on Current Treatments of Legg-Calvé-Perthes DiseaseRecruitingNCT02040714
6WOMAC Hip Score in Children and Adolescents With Perthes DiseaseRecruitingNCT02795494
7Evaluate E1 Wear, Clinical Performance of E1 Liner in THA in Korean Patient PopulationActive, not recruitingNCT02087449
8The Effect of Perthes' Disease on Hip CartilageSuspendedNCT00958464
9Intraarticular Corticosteroid Therapy in Perthes Disease.TerminatedNCT01026909

Search NIH Clinical Center for Legg-Calve-Perthes Disease


Cochrane evidence based reviews: legg-calve-perthes disease

Genetic Tests for Legg-Calve-Perthes Disease

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Genetic tests related to Legg-Calve-Perthes Disease:

id Genetic test Affiliating Genes
1 Coxa Plana25

Anatomical Context for Legg-Calve-Perthes Disease

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MalaCards organs/tissues related to Legg-Calve-Perthes Disease:

34
Bone, Skeletal muscle

FMA organs/tissues related to Legg-Calve-Perthes Disease:

17
Hip joint

Animal Models for Legg-Calve-Perthes Disease or affiliated genes

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MGI Mouse Phenotypes related to Legg-Calve-Perthes Disease:

39 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.0COL2A1, SELE, SELP, SERPINE1, THBD
2MP:00053707.8COL2A1, SELE, SELP, SERPINC1, SERPINE1, THBD
3MP:00036317.7CD40LG, COL2A1, PEPD, SELP, SERPINC1, THBD
4MP:00107717.6CD40LG, PEPD, SELE, SELP, SERPINE1, THBD
5MP:00053977.4CD40LG, SELE, SELP, SERPINC1, SERPINE1, THBD
6MP:00053877.2CD40LG, COL2A1, SELE, SELP, SERPINC1, SERPINE1
7MP:00053676.9CD40LG, COL2A1, PEPD, SELP, SERPINC1, SERPINE1
8MP:00107686.5CD40LG, COL2A1, PEPD, SELE, SELP, SERPINC1
9MP:00053766.4CD40LG, COL2A1, PEPD, SELE, SELP, SERPINC1
10MP:00053856.3CD40LG, COL2A1, PEPD, SELE, SELP, SERPINC1

Publications for Legg-Calve-Perthes Disease

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Articles related to Legg-Calve-Perthes Disease:

(show top 50)    (show all 99)
idTitleAuthorsYear
1
Comparative study of serum proteomes in Legg-Calve-Perthes disease. (26438379)
2015
2
Treatment of Arthritis Associated With Legg-Calve-Perthes Disease With Modular Total Hip Arthroplasty. (25979188)
2015
3
TAPnnis triple pelvic osteotomy for Legg-Calve-Perthes disease. (25417791)
2015
4
Advanced Containment With Triple Innominate Osteotomy in Legg-Calve-Perthes Disease: A Viable Option Even in Severe Cases. (26683505)
2015
5
Guided growth of the trochanteric apophysis combined with soft tissue release for Legg-Calve-Perthes disease. (24563149)
2014
6
Local delivery of recombinant human bone morphogenetic proteins and bisphosphonate via sucrose acetate isobutyrate can prevent femoral head collapse in Legg-Calve-Perthes disease: a pilot study in pigs. (24389948)
2014
7
Increased soluble selectins as a reflection of activated platelets and endothelium in Legg-Calve-Perthes disease. (25000467)
2014
8
Shelf Acetabuloplasty for Containment in the Early Stages of Legg-Calve-Perthes Disease. (24840656)
2014
9
Diffusion MRI of the neck of the femur in Legg-Calve-Perthes disease: a preliminary study. (23206418)
2013
10
MR perfusion index as a quantitative method of evaluating epiphyseal perfusion in Legg-Calve-Perthes disease and correlation with short-term radiographic outcome: a preliminary study. (23872796)
2013
11
Custom Cementless THA in Patients With Legg-Calve-Perthes Disease. (24018160)
2013
12
Combined osteotomy in patients with severe Legg-Calve-Perthes disease. (23451451)
2012
13
Natural history of early onset and late-onset Legg-Calve-Perthes disease. (21857430)
2011
14
Serum prolidase activity and oxidative-antioxidative status in Legg-Calve-Perthes disease. (21304409)
2011
15
Legg-Calve-Perthes disease: etiology, pathogenesis, and biology. (21857428)
2011
16
The role of bracing in Legg-Calve-Perthes disease. (21857435)
2011
17
Legg-Calve-Perthes disease in a patient with Albright hereditary osteodystrophy: a case report. (20124073)
2010
18
Legg-Calve-Perthes disease and risks for cardiovascular diseases and blood diseases. (20439602)
2010
19
Triple pelvic osteotomy in Legg-Calve-Perthes disease using a single anterolateral incision: a 4-year review. (20386118)
2010
20
Varus producing osteotomy for patients with lateral pillar type B and C Legg-Calve-Perthes disease followed to skeletal maturity. Castaneda et al. JCOR (2008), 2:373-379. (19308615)
2009
21
Triple pelvic osteotomy in the treatment of Legg-Calve-Perthes disease. (19301002)
2009
22
Systemic effects of zoledronic acid in children with traumatic femoral head avascular necrosis and Legg-Calve-Perthes disease. (19446052)
2009
23
Thrombomodulin and GFC levels in Legg-Calve-Perthes disease. (19055859)
2008
24
A histological and ultrastructural study of the iliac crest apophysis in Legg-Calve-Perthes disease. (18520280)
2008
25
Sagittal spinal alignment in patients with Legg-Calve-Perthes disease. (17875086)
2007
26
Interruption of the blood supply of femoral head: an experimental study on the pathogenesis of Legg-Calve-Perthes Disease. (17598118)
2007
27
Outcome of cheilectomy in Legg-Calve-Perthes disease: minimum 25-year follow-up of five patients. (16557136)
2006
28
Protein C levels in patients with Legg-Calve-Perthes disease: is it a true deficiency? (16557135)
2006
29
Lateral acetabular growth stimulation following a labral support procedure in Legg-Calve-Perthes disease. (16818970)
2006
30
Automated analysis of MR image of hip: geometrical evaluation of the Legg-Calve-Perthes disease. (15863350)
2005
31
The correlation between coxa magna and final outcome in Legg-Calve-Perthes disease. (15614054)
2005
32
Legg-Calve-Perthes disease. Part I: Classification of radiographs with use of the modified lateral pillar and Stulberg classifications. (15466719)
2004
33
Avascular necrosis of the femoral heads in a red panda (Ailurus fulgens fulgens): possible Legg-Calve-Perthes disease. (12462497)
2002
34
Fate of the osteochondral fragments in osteochondritis dissecans after Legg-Calve-Perthes' disease. (12358366)
2002
35
Hip arthroscopy in Legg-Calve-Perthes disease. (10024039)
1999
36
Legg-Calve-Perthes Disease. (10790676)
1996
37
Growth profiles and articular cartilage characterization in a goat model of Legg-Calve-Perthes disease. (8751151)
1995
38
Ultrasonographic evaluation of Legg-Calve-Perthes disease based on sonoanatomic criteria and the application of new measuring techniques. (1425742)
1992
39
Surgical treatment of Legg-Calve-Perthes disease. (1345635)
1992
40
An instrumented brace for study of Legg-Calve-Perthes disease. (3452429)
1987-1988
41
Three-dimensional finite element analysis of Legg-Calve-Perthes disease. (7076833)
1982
42
Legg-Calve-Perthes disease associated with hereditary multiple exostosis: a case report. (306501)
1978
43
Alternative treatments in Legg-Calve-Perthes disease. (268224)
1977
44
Legg-Calve-Perthes disease: a statistical evaluation of 358 cases. (4539905)
1973
45
A study of the radiographic and histological changes occurring in Legg-Calve-Perthes disease (LCP) in the dog. (5531150)
1970
46
Developmental variation in epiphyseogenesis of the femoral head on the unaffected hip in unilateral Legg-Calve-Perthes disease. (5247151)
1968
47
Legg-Calve-Perthes disease: clinical-radiographic correlations. (5832723)
1965
48
Legg-Calve-Perthes disease: the roentgenologic changes with therapy in forty patients. (14486234)
1962
49
Inherited vascular pattern of the femoral head and neck as a predisposing factor to Legg-Calve-Perthes disease. (13932250)
1962
50
The deformity in Legg-Calve-Perthes disease. (13716060)
1960

Variations for Legg-Calve-Perthes Disease

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Clinvar genetic disease variations for Legg-Calve-Perthes Disease:

5
id Gene Variation Type Significance SNP ID Assembly Location
1COL2A1NM_001844.4(COL2A1): c.3508G> A (p.Gly1170Ser)single nucleotide variantPathogenicrs121912891GRCh37Chr 12, 48369835: 48369835

Expression for genes affiliated with Legg-Calve-Perthes Disease

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Search GEO for disease gene expression data for Legg-Calve-Perthes Disease.

Pathways for genes affiliated with Legg-Calve-Perthes Disease

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Pathways related to Legg-Calve-Perthes Disease according to GeneCards Suite gene sharing:

(show all 11)
idSuper pathwaysScoreTop Affiliating Genes
19.6COL2A1, SERPINE1
29.6CD40LG, COL2A1
39.3CD40LG, SELP
4
Show member pathways
9.3COL2A1, SERPINC1, THBD
5
Show member pathways
9.1SERPINC1, SERPINE1, THBD
6
Show member pathways
9.1SERPINC1, SERPINE1, THBD
78.7SELE, SERPINE1, THBD
8
Show member pathways
8.6SELE, SELP, THBD
98.5CD40LG, SELE, SELP
108.5CD40LG, SELE, SELP
11
Show member pathways
7.7SELE, SELP, SERPINC1, SERPINE1, THBD

GO Terms for genes affiliated with Legg-Calve-Perthes Disease

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Cellular components related to Legg-Calve-Perthes Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056156.8CD40LG, COL2A1, SELE, SELP, SERPINC1, SERPINE1

Biological processes related to Legg-Calve-Perthes Disease according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1collagen catabolic processGO:003057410.1COL2A1, PEPD
2negative regulation of blood coagulationGO:003019510.1SERPINE1, THBD
3negative regulation of fibrinolysisGO:005191810.0SERPINE1, THBD
4leukocyte tethering or rollingGO:00509019.6SELE, SELP
5heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesGO:00071579.4SELE, SELP
6defense response to Gram-negative bacteriumGO:00508299.0SELP, SERPINE1
7leukocyte cell-cell adhesionGO:00071599.0CD40LG, SELE, SELP
8inflammatory responseGO:00069548.6CD40LG, SELE, SELP
9leukocyte migrationGO:00509008.6SELE, SELP, THBD
10response to lipopolysaccharideGO:00324968.5SELE, SELP, THBD

Molecular functions related to Legg-Calve-Perthes Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1sialic acid bindingGO:00336919.0SELE, SELP
2oligosaccharide bindingGO:00704929.0SELE, SELP

Sources for Legg-Calve-Perthes Disease

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet