MCID: LGN002
MIFTS: 65

Legionellosis

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Legionellosis

MalaCards integrated aliases for Legionellosis:

Name: Legionellosis 12 72 49 55 28 3 41 14 69
Legionella Infection 12 49
Legionnaires Disease 55 51
Pontiac Fever 49 69
Legionaire Disease, Susceptibility to 13
Legionnaires' Disease 69
Legionnaire's Disease 49

Characteristics:

Orphanet epidemiological data:

55
legionellosis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe),1-9/100000 (France); Age of onset: All ages;

Classifications:

Orphanet: 55  
Rare infectious diseases


Summaries for Legionellosis

CDC : 3 Legionnaires’ (LEE-juh-nares) disease is caused by a type of bacterium called Legionella (LEE-juh-nell-a). The bacterium is named after a 1976 outbreak, during which some people who went to a Philadelphia convention of the American Legion suffered from a new type of pneumonia (lung infection) that became known as Legionnaires’ disease. A milder infection, also caused by Legionella, is called Pontiac fever. The term “legionellosis” (LEE-juh-nuh-low-sis) may be used to refer to either Legionnaires’ disease or Pontiac fever.

MalaCards based summary : Legionellosis, also known as legionella infection, is related to legionnaires' disease and brucellosis, and has symptoms including renal insufficiency, proteinuria and hallucinations. An important gene associated with Legionellosis is TLR5 (Toll Like Receptor 5), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Azithromycin and Clarithromycin have been mentioned in the context of this disorder. Affiliated tissues include respiratory tract, lung and testes, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Disease Ontology : 12 A primary bacterial infectious disease that results_in infection located in respiratory tract, has material basis in Legionella pneumophila, which is transmitted_by inhalation of droplets containing bacteria. The symptoms include dry cough, fever, headache and diarrhea.

Wikipedia : 72 Legionnaires\' disease is a form of atypical pneumonia caused by any type of Legionella bacteria. Signs... more...

Related Diseases for Legionellosis

Diseases related to Legionellosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 117)
# Related Disease Score Top Affiliating Genes
1 legionnaires' disease 30.6 CASP1 CD40LG NLRC4 PIK3C2A TLR4 TLR5
2 brucellosis 28.9 CD40LG TLR4 TNF
3 pneumonia 28.5 CD40LG PIK3C2A TLR2 TLR4 TLR5 TNF
4 pontiac fever 11.3
5 prosthetic joint infection 10.3 TLR2 TLR4
6 retinitis pigmentosa 49 10.3 EEF1A2 HBS1L
7 enterocolitis 10.3 NLRC4 TLR4
8 acute cervicitis 10.3 TLR2 TLR4
9 granulomatous myositis 10.2 NAIP PIK3C2A
10 suppurative otitis media 10.2 TLR2 TLR4 TLR5
11 paratyphoid fever 10.2 CASP1 TNF
12 macrophage activation syndrome 10.2 NLRC4 TNF
13 legionnaire disease 10.1
14 spondylarthropathy 10.1 TLR4 TNF
15 tympanosclerosis 10.1 TLR4 TNF
16 haemophilus influenzae 10.1 TLR2 TNF
17 ocular toxoplasmosis 10.1 CD40LG TLR5
18 nontuberculous mycobacterial lung disease 10.0 TLR2 TNF
19 anterior uveitis 10.0 TLR4 TNF
20 heavy chain disease 10.0 CD40LG MYD88
21 monoclonal paraproteinemia 10.0 CD40LG MYD88
22 mycobacterium abscessus 10.0 TLR2 TNF
23 erysipelas 10.0 PIK3C2A TNF
24 myd88 deficiency 9.9 MYD88 TLR2 TLR4 TLR5
25 irak4 deficiency 9.9 MYD88 TLR2 TLR4 TLR5
26 coccidioidomycosis 9.9 CD40LG TLR4
27 trichostrongyloidiasis 9.9 CD40LG PIK3C2A
28 penicilliosis 9.9 TLR2 TLR4 TNF
29 alveolar echinococcosis 9.9 TLR2 TLR4 TNF
30 bacterial vaginosis 9.9 TLR2 TLR4 TNF
31 paracoccidioidomycosis 9.9 TLR2 TLR4 TNF
32 ornithosis 9.9 CD40LG PIK3C2A
33 filariasis 9.9 TLR2 TLR4 TNF
34 tularemia 9.9 CASP1 TLR2
35 cutaneous leishmaniasis 9.9 TLR2 TLR4 TNF
36 lymphoplasmacytic lymphoma 9.9 CD40LG MYD88
37 periodontitis 9.9 TLR2 TLR4 TNF
38 chagas disease 9.9 TLR2 TLR4 TNF
39 visceral leishmaniasis 9.9 TLR2 TLR4 TNF
40 plasma protein metabolism disease 9.8 CD40LG MYD88
41 leishmaniasis 9.8 TLR2 TLR4 TNF
42 periodontal disease 9.8 TLR2 TLR4 TNF
43 aspergillosis 9.8
44 leukemia 9.8
45 invasive aspergillosis 9.8
46 lung abscess 9.8
47 pertussis 9.8
48 encephalitozoonosis 9.8 CD40LG TNF
49 rheumatoid lung disease 9.8 CD40LG TNF
50 bacterial meningitis 9.8 PIK3C2A TLR2 TNF

Graphical network of the top 20 diseases related to Legionellosis:



Diseases related to Legionellosis

Symptoms & Phenotypes for Legionellosis

Human phenotypes related to Legionellosis:

55 31 (show all 43)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 renal insufficiency 55 31 occasional (7.5%) Occasional (29-5%) HP:0000083
2 proteinuria 55 31 occasional (7.5%) Occasional (29-5%) HP:0000093
3 hallucinations 55 31 occasional (7.5%) Occasional (29-5%) HP:0000738
4 hematuria 55 31 occasional (7.5%) Occasional (29-5%) HP:0000790
5 jaundice 55 31 occasional (7.5%) Occasional (29-5%) HP:0000952
6 ataxia 55 31 occasional (7.5%) Occasional (29-5%) HP:0001251
7 muscle weakness 55 31 occasional (7.5%) Occasional (29-5%) HP:0001324
8 pericarditis 55 31 occasional (7.5%) Occasional (29-5%) HP:0001701
9 pancreatitis 55 31 occasional (7.5%) Occasional (29-5%) HP:0001733
10 splenomegaly 55 31 occasional (7.5%) Occasional (29-5%) HP:0001744
11 lymphopenia 55 31 occasional (7.5%) Occasional (29-5%) HP:0001888
12 fever 55 31 hallmark (90%) Very frequent (99-80%) HP:0001945
13 diarrhea 55 31 occasional (7.5%) Occasional (29-5%) HP:0002014
14 nausea and vomiting 55 31 occasional (7.5%) Occasional (29-5%) HP:0002017
15 abdominal pain 55 31 occasional (7.5%) Occasional (29-5%) HP:0002027
16 anorexia 55 31 occasional (7.5%) Occasional (29-5%) HP:0002039
17 migraine 55 31 occasional (7.5%) Occasional (29-5%) HP:0002076
18 respiratory insufficiency 55 31 frequent (33%) Frequent (79-30%) HP:0002093
19 abnormality of the pleura 55 31 occasional (7.5%) Occasional (29-5%) HP:0002103
20 hemoptysis 55 31 occasional (7.5%) Occasional (29-5%) HP:0002105
21 pulmonary infiltrates 55 31 hallmark (90%) Very frequent (99-80%) HP:0002113
22 encephalitis 55 31 occasional (7.5%) Occasional (29-5%) HP:0002383
23 hypotension 55 31 occasional (7.5%) Occasional (29-5%) HP:0002615
24 lymphadenopathy 55 31 occasional (7.5%) Occasional (29-5%) HP:0002716
25 arthralgia 55 31 occasional (7.5%) Occasional (29-5%) HP:0002829
26 hyponatremia 55 31 occasional (7.5%) Occasional (29-5%) HP:0002902
27 myalgia 55 31 hallmark (90%) Very frequent (99-80%) HP:0003326
28 reduced consciousness/confusion 55 31 occasional (7.5%) Occasional (29-5%) HP:0004372
29 bone marrow hypocellularity 55 31 occasional (7.5%) Occasional (29-5%) HP:0005528
30 peripheral neuropathy 55 31 occasional (7.5%) Occasional (29-5%) HP:0009830
31 arrhythmia 55 31 frequent (33%) Frequent (79-30%) HP:0011675
32 hepatitis 55 31 occasional (7.5%) Occasional (29-5%) HP:0012115
33 fatigue 55 31 hallmark (90%) Very frequent (99-80%) HP:0012378
34 cough 55 31 hallmark (90%) Very frequent (99-80%) HP:0012735
35 myocarditis 55 31 occasional (7.5%) Occasional (29-5%) HP:0012819
36 endocarditis 55 31 occasional (7.5%) Occasional (29-5%) HP:0100584
37 cellulitis 55 31 occasional (7.5%) Occasional (29-5%) HP:0100658
38 chest pain 55 31 frequent (33%) Frequent (79-30%) HP:0100749
39 recurrent pharyngitis 55 31 occasional (7.5%) Occasional (29-5%) HP:0100776
40 sepsis 55 31 occasional (7.5%) Occasional (29-5%) HP:0100806
41 abnormality of lung morphology 55 Very frequent (99-80%)
42 restrictive lung disease 55 Occasional (29-5%)
43 restrictive ventilatory defect 31 occasional (7.5%) HP:0002091

UMLS symptoms related to Legionellosis:


snoring, pruritus, fever, coughing

GenomeRNAi Phenotypes related to Legionellosis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.32 CASP1 CD40LG MYD88 TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.32 CASP1 CD40LG MYD88 NAIP NLRC4 TNF

MGI Mouse Phenotypes related to Legionellosis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.1 TLR4 MYD88 TNF CASP1 NLRC4 PIK3C2A
2 cardiovascular system MP:0005385 10.03 TLR5 MYD88 TNF CASP1 PIK3C2A CD40LG
3 adipose tissue MP:0005375 10 HBS1L TLR4 MYD88 TNF PIK3C2A TLR2
4 hematopoietic system MP:0005397 10 TLR4 MYD88 TNF CASP1 NLRC4 PIK3C2A
5 immune system MP:0005387 9.9 TLR4 MYD88 TNF CASP1 NLRC4 PIK3C2A
6 endocrine/exocrine gland MP:0005379 9.87 TLR5 MYD88 TNF CASP1 CD40LG EEF1A2
7 digestive/alimentary MP:0005381 9.85 TLR5 MYD88 TNF CASP1 TLR4 TLR2
8 mortality/aging MP:0010768 9.65 TLR5 ARF1 MYD88 TNF CASP1 PIK3C2A
9 renal/urinary system MP:0005367 9.1 MYD88 CASP1 PIK3C2A CD40LG TLR4 TLR2

Drugs & Therapeutics for Legionellosis

Drugs for Legionellosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4 83905-01-5 53477736 447043 55185
2
Clarithromycin Approved Phase 4 81103-11-9 84029
3
Erythromycin Approved, Investigational, Vet_approved Phase 4 114-07-8 12560
4 Anti-Bacterial Agents Phase 4,Phase 1
5 Antibiotics, Antitubercular Phase 4,Phase 1
6 Anti-Infective Agents Phase 4,Phase 1
7 Antitubercular Agents Phase 4,Phase 1
8 Cytochrome P-450 CYP3A Inhibitors Phase 4
9 Cytochrome P-450 Enzyme Inhibitors Phase 4
10 Erythromycin Estolate Phase 4
11 Erythromycin Ethylsuccinate Phase 4
12 Erythromycin stearate Phase 4
13
Estradiol Approved, Investigational, Vet_approved Phase 1 50-28-2 5757
14
Ethinyl Estradiol Approved Phase 1 57-63-6 5991
15
Isoniazid Approved, Investigational Phase 1 54-85-3 3767
16
Kanamycin Approved, Investigational, Vet_approved Phase 1 59-01-8, 8063-07-8 6032
17
Moxifloxacin Approved, Investigational Phase 1 151096-09-2, 354812-41-2 152946
18
Norgestimate Approved, Investigational Phase 1 35189-28-7 6540478
19
Pyrazinamide Approved, Investigational Phase 1 98-96-4 1046
20
Rifampin Approved Phase 1 13292-46-1 5381226 5458213
21
Streptomycin Approved, Vet_approved Phase 1 57-92-1 19649
22
Niacin Approved, Investigational, Nutraceutical Phase 1 59-67-6 938
23
Nicotinamide Approved, Investigational, Nutraceutical Phase 1 98-92-0 936
24 Antimetabolites Phase 1
25 Catalase Phase 1
26 Contraceptive Agents Phase 1
27 Contraceptives, Oral Phase 1
28 Contraceptives, Oral, Combined Phase 1
29 Cytochrome P-450 CYP3A Inducers Phase 1
30 Estradiol 17 beta-cypionate Phase 1
31 Estradiol 3-benzoate Phase 1
32 Estradiol valerate Phase 1 979-32-8
33 Fluoroquinolones Phase 1
34 Hypolipidemic Agents Phase 1
35 Lipid Regulating Agents Phase 1
36 Nicotinic Acids Phase 1
37 Norgestimate, ethinyl estradiol drug combination Phase 1
38 Nucleic Acid Synthesis Inhibitors Phase 1
39 Polyestradiol phosphate Phase 1
40 Topoisomerase Inhibitors Phase 1
41 Vitamin B3 Nutraceutical Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Aizthromycin or Clarithromycin in H-pylori Eradication Regimen Completed NCT01667692 Phase 4 azithromycin;clarithmycin
2 Measurement of Anti-TB Drugs in Lung Tissue From Patients Having Surgery to Treat Tuberculosis Completed NCT00816426 Phase 1 Rifampicin;Isoniazid;Pyrazinamide;Kanamycin;Moxifloxacin
3 Severe Legionellosis Cases Admitted to Grenoble University Hospital, 2006-2011. Completed NCT02884700
4 Special Investigation Of Azithromycin IV For Legionnaires' Disease (Regulatory Post Marketing Commitment Plan) Completed NCT01784770 Azithromycin IV
5 Community Acquired Pneumonia in Telemark and Ostfold Completed NCT00467701
6 Legionnaires' Effect on Smell Recruiting NCT03321786
7 Bacterial and Human Biomarkers of Prognostic Value for Severe Legionnaire's Disease Not yet recruiting NCT03064737
8 Impact of Legionella Urine Antigen Testing (LUAT) on the Local Epidemiology and Diagnosis of Legionella Pneumonia Not yet recruiting NCT03200275
9 Evaluation of Legionella PCR Techniques for the Routine Diagnosis of Legionellosis Terminated NCT00452153

Search NIH Clinical Center for Legionellosis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: legionellosis

Genetic Tests for Legionellosis

Genetic tests related to Legionellosis:

# Genetic test Affiliating Genes
1 Legionellosis 28 TLR5

Anatomical Context for Legionellosis

The Foundational Model of Anatomy Ontology organs/tissues related to Legionellosis:

18
Respiratory Tract

MalaCards organs/tissues related to Legionellosis:

38
Lung, Testes, Bone Marrow, Bone, Colon, Heart, T Cells

Publications for Legionellosis

Articles related to Legionellosis:

(show top 50) (show all 325)
# Title Authors Year
1
Of Time and the River: How Our Understanding of Legionellosis Has Changed Since 1976. ( 29211906 )
2018
2
Combining Environmental Investigation and a Dual-Analytical Strategy to Isolate the Legionella longbeachae Strain Linked to Two Occupational Cases of Legionellosis. ( 29304227 )
2018
3
Association Between Sporadic Legionellosis and River Systems in Connecticut. ( 29211873 )
2018
4
Genome Sequencing Links Persistent Outbreak of Legionellosis in Sydney (New South Wales, Australia) to an Emerging Clone of Legionella pneumophila Sequence Type 211. ( 29247056 )
2018
5
Notes from the Field: Legionellosis Outbreak Associated with a Hotel Aquatics Facility - Tennessee, 2017. ( 29346335 )
2018
6
Legionella prevalence and risk of legionellosis in Japanese households. ( 28166862 )
2017
7
Nosocomial legionellosis and invasive aspergillosis in a child with T-lymphoblastic leukemia. ( 28529020 )
2017
8
Legionnaires' Disease (Legionella Infection) ( 28613558 )
2017
9
Comparison of sputum microbiome of legionellosis-associated patients and other pneumonia patients: indications for polybacterial infections. ( 28059171 )
2017
10
Diagnosis of Extrapulmonary Legionellosis in Allogeneic Hematopoietic Cell Transplant Recipients by Direct 16S Ribosomal Ribonucleic Acid Sequencing and Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry. ( 28852679 )
2017
11
From 'Legionellosis acquired through a dental unit' to 'Was Legionellosis acquired through a dental unit?' ( 28457583 )
2017
12
Male Neonate with Legionellosis. ( 29194478 )
2017
13
Is Legionellosis Present and Important in Colombia? An Analyses of Cases from 2009 to 2013. ( 28465870 )
2017
14
Risk assessment of legionellosis in cardiology units. ( 28900358 )
2017
15
Legionellosis: a Walk-through to Identification of the Source of Infection. ( 29022684 )
2017
16
Legionellosis following water birth in a hot tub in a Canadian neonate. ( 29061856 )
2017
17
Analysis of population-level determinants of legionellosis: spatial and geovisual methods for enhancing classification of high-risk areas. ( 29197383 )
2017
18
Legionellosis in the occupational setting. ( 27717486 )
2017
19
Legionella longbeachae detected in an industrial cooling tower linked to a legionellosis outbreak, New Zealand, 2015; possible waterborne transmission? ( 28625225 )
2017
20
Legionellosis in Poland in 2015 ( 29181967 )
2017
21
Legionellosis acquired through a dental unit: a case study. ( 28228245 )
2017
22
A single Legionella pneumophila genotype in the freshwater system in a ship experiencing three separate outbreaks of legionellosis in 6 years. ( 27515183 )
2016
23
Case of Legionella pneumophila pneumonia (legionellosis) developed in a psoriatic arthritis patient receiving adalimumab. ( 27651216 )
2016
24
Legionellosis in Poland in 2014 ( 27779835 )
2016
25
Pulmonary Legionellosis in Oncologic Patients: Findings on Chest CT. ( 27454787 )
2016
26
Legionellosis protection requirements. How to comply with ASHRAE's standard for building water systems. ( 27323504 )
2016
27
Legionellosis in Transplantation. ( 26857395 )
2016
28
Microbiological diagnosis and molecular typing of Legionella strains during an outbreak of legionellosis in Southern Germany. ( 26868659 )
2016
29
Under the Weather: Legionellosis and Meteorological Factors. ( 26993637 )
2016
30
Fatal legionellosis after water birth, Texas, USA, 2014. ( 25531804 )
2015
31
Legionellosis Outbreak Associated With a Hotel Fountain. ( 26716104 )
2015
32
Cross-reactions in IgM ELISA tests to Legionella pneumophila sg1 and Bordetella pertussis among children suspected of legionellosis; potential impact of vaccination against pertussis? ( 26557032 )
2015
33
Microbiological and Clinical Studies of Legionellosis in 33 Patients with Cancer. ( 25926494 )
2015
34
Active Bacterial Core Surveillance for Legionellosis - United States, 2011-2013. ( 26513329 )
2015
35
Reducing the risk of legionellosis in stem cell transplant recipients. ( 25581611 )
2015
36
Legionellosis and psoriasis in biologic era. ( 25686289 )
2015
37
A Review of Guidelines for the Primary Prevention of Legionellosis inA Long-Term Care Facilities. ( 26155722 )
2015
38
Legionellosis in Poland in 2013. ( 26233078 )
2015
39
Problem of immunoglobulin M co-detection in serological response to bacterial and viral respiratory pathogens among children suspected of legionellosis. ( 26557031 )
2015
40
Utility of PCR, Culture, and Antigen Detection Methods for Diagnosis of Legionellosis. ( 26292304 )
2015
41
Post-Legionellosis Proliferative Glomerulonephritis. ( 26648502 )
2015
42
Reducing the risk for waterborne nosocomial neonatal legionellosis. ( 25988326 )
2015
43
Legionella prevalence and risk of legionellosis in Hungarian hospitals. ( 26689882 )
2015
44
Genomic Investigation of a Legionellosis Outbreak in a Persistently Colonized Hotel. ( 26834713 )
2015
45
Cutaneous legionellosis: case report and review of the medical literature. ( 24628820 )
2014
46
Legionellosis in Military Health System beneficiaries, 1998-2013. ( 24684614 )
2014
47
Granulocyte-macrophage colony stimulating factor for non-resolving legionellosis. ( 25342420 )
2014
48
Molecular Characterization of Legionellosis Drug Target Candidate Enzyme Phosphoglucosamine Mutase from Legionella pneumophila (strain Paris): An In Silico Approach. ( 25705169 )
2014
49
Draft Genome Sequence of a Legionella pneumophila Serogroup 4 Strain Causing Legionellosis. ( 24948769 )
2014
50
Community outbreak of legionellosis and an environmental investigation into a community water system. ( 25083716 )
2014

Variations for Legionellosis

Expression for Legionellosis

Search GEO for disease gene expression data for Legionellosis.

Pathways for Legionellosis

Pathways related to Legionellosis according to GeneCards Suite gene sharing:

(show all 37)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.9 ARF1 CASP1 CD40LG MYD88 NLRC4 TLR2
2
Show member pathways
13.28 CD40LG MYD88 TLR2 TLR4 TLR5 TNF
3
Show member pathways
13.08 MYD88 PIK3C2A TLR2 TLR4 TLR5 TNF
4
Show member pathways
12.69 CASP1 MYD88 TLR2 TLR4 TNF
5
Show member pathways
12.68 CASP1 MYD88 NAIP NLRC4 TLR2 TLR4
6
Show member pathways
12.57 CD40LG MYD88 TLR2 TLR4 TLR5 TNF
7
Show member pathways
12.49 TLR2 TLR4 TLR5 TNF
8
Show member pathways
12.46 MYD88 TLR2 TLR4 TNF
9 12.45 CD40LG MYD88 TLR2 TNF
10
Show member pathways
12.44 CASP1 CD40LG MYD88 TLR2 TLR4 TLR5
11
Show member pathways
12.42 MYD88 TLR2 TLR4 TLR5 TNF
12
Show member pathways
12.14 MYD88 TLR4 TNF
13 12.13 MYD88 TLR2 TLR4 TNF
14
Show member pathways
12.13 MYD88 TLR2 TLR4 TLR5 TNF
15
Show member pathways
12.1 CD40LG MYD88 TLR2 TLR4 TNF
16 12.09 TLR2 TLR4 TLR5 TNF
17
Show member pathways
12.02 MYD88 TLR2 TLR4 TLR5 TNF
18 11.95 TLR2 TLR4 TLR5
19
Show member pathways
11.94 PIK3C2A TLR2 TLR4 TLR5
20
Show member pathways
11.84 TLR2 TLR4 TLR5 TNF
21 11.79 TLR2 TLR4 TNF
22 11.79 CD40LG MYD88 TLR4 TNF
23
Show member pathways
11.76 TLR2 TLR4 TLR5
24 11.75 TLR2 TLR4 TNF
25 11.72 TLR2 TLR4 TLR5
26 11.68 CASP1 MYD88 TLR4 TNF
27 11.65 CASP1 MYD88 NLRC4 TLR4 TLR5
28 11.63 MYD88 TLR4 TNF
29 11.5 MYD88 TLR4 TNF
30 11.44 TLR2 TLR4 TNF
31 11.37 CD40LG TLR2 TLR4 TLR5 TNF
32 11.35 CASP1 NAIP NLRC4
33 11.1 ARF1 CASP1 EEF1A2 HBS1L MYD88 NAIP
34 11.07 MYD88 TLR2
35 11.04 CD40LG MYD88 TLR2 TLR4 TNF
36 11.01 CASP1 TNF
37 10.98 MYD88 TLR2

GO Terms for Legionellosis

Cellular components related to Legionellosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intracellular GO:0005622 9.5 ARF1 CD40LG HBS1L NLRC4 PIK3C2A TLR4
2 IPAF inflammasome complex GO:0072557 8.62 CASP1 NLRC4

Biological processes related to Legionellosis according to GeneCards Suite gene sharing:

(show all 45)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.99 MYD88 TLR2 TLR4 TNF
2 innate immune response GO:0045087 9.99 MYD88 NAIP NLRC4 TLR2 TLR4 TLR5
3 immune system process GO:0002376 9.95 MYD88 NAIP NLRC4 TLR2 TLR4 TLR5
4 defense response to bacterium GO:0042742 9.92 NLRC4 TLR4 TLR5 TNF
5 response to lipopolysaccharide GO:0032496 9.91 CASP1 MYD88 TLR2 TLR4
6 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.88 CASP1 MYD88 TLR4 TNF
7 cellular response to lipopolysaccharide GO:0071222 9.86 CASP1 TLR4 TLR5 TNF
8 defense response to Gram-positive bacterium GO:0050830 9.84 MYD88 TLR2 TNF
9 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.83 CASP1 NLRC4 TNF
10 positive regulation of JNK cascade GO:0046330 9.8 MYD88 TLR4 TNF
11 positive regulation of tumor necrosis factor production GO:0032760 9.77 MYD88 TLR2 TLR4
12 toll-like receptor signaling pathway GO:0002224 9.76 MYD88 TLR2 TLR4
13 cellular response to mechanical stimulus GO:0071260 9.76 CASP1 MYD88 TLR4 TLR5
14 positive regulation of nitric oxide biosynthetic process GO:0045429 9.74 TLR4 TLR5 TNF
15 regulation of inflammatory response GO:0050727 9.73 CASP1 MYD88 TLR4 TNF
16 positive regulation of interleukin-12 production GO:0032735 9.72 CD40LG TLR2 TLR4
17 positive regulation of interleukin-10 production GO:0032733 9.71 CD40LG TLR2 TLR4
18 negative regulation of interleukin-6 production GO:0032715 9.7 TLR4 TNF
19 positive regulation of NF-kappaB import into nucleus GO:0042346 9.7 TLR2 TLR4 TNF
20 positive regulation of interferon-beta production GO:0032728 9.69 TLR2 TLR4
21 positive regulation of interleukin-1 beta secretion GO:0050718 9.69 CASP1 TLR4
22 activation of innate immune response GO:0002218 9.69 NLRC4 TLR4
23 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.68 MYD88 TLR4
24 negative regulation of growth of symbiont in host GO:0044130 9.68 MYD88 TNF
25 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.68 TLR2 TLR4
26 I-kappaB phosphorylation GO:0007252 9.67 TLR2 TLR4
27 positive regulation of chemokine production GO:0032722 9.67 TLR2 TLR4 TNF
28 positive regulation of interleukin-6 production GO:0032755 9.67 MYD88 TLR2 TLR4 TNF
29 cellular response to lipoteichoic acid GO:0071223 9.66 TLR2 TLR4
30 inhibition of cysteine-type endopeptidase activity involved in apoptotic process GO:1990001 9.66 NAIP NLRC4
31 interleukin-1 beta secretion GO:0050702 9.65 NLRC4 TLR4
32 positive regulation of chemokine biosynthetic process GO:0045080 9.65 MYD88 TNF
33 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.64 TLR4 TNF
34 positive regulation of lymphocyte proliferation GO:0050671 9.64 MYD88 TLR4
35 pyroptosis GO:0070269 9.63 CASP1 NLRC4
36 cellular response to oxidised low-density lipoprotein particle stimulus GO:0140052 9.62 MYD88 TLR4
37 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.62 MYD88 TLR2 TLR4 TLR5
38 regulation of immunoglobulin secretion GO:0051023 9.61 CD40LG TNF
39 positive regulation of toll-like receptor signaling pathway GO:0034123 9.59 TLR2 TLR5
40 regulation of cytokine secretion GO:0050707 9.58 TLR2 TLR4 TLR5
41 lipopolysaccharide-mediated signaling pathway GO:0031663 9.56 MYD88 TLR2 TLR4 TNF
42 positive regulation of interleukin-8 production GO:0032757 9.46 TLR2 TLR4 TLR5 TNF
43 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.43 CD40LG MYD88 NLRC4 TLR2 TLR4 TNF
44 inflammatory response GO:0006954 9.23 CD40LG MYD88 NAIP NLRC4 TLR2 TLR4
45 apoptotic process GO:0006915 10.07 CASP1 MYD88 NAIP NLRC4 TLR2

Molecular functions related to Legionellosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043027 9.32 NAIP NLRC4
2 translation elongation factor activity GO:0003746 9.26 EEF1A2 HBS1L
3 interleukin-1 receptor binding GO:0005149 9.16 MYD88 TLR5
4 Toll-like receptor binding GO:0035325 8.96 MYD88 TLR2
5 lipopolysaccharide receptor activity GO:0001875 8.62 TLR2 TLR4

Sources for Legionellosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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