Legius Syndrome

Categories: Genetic diseases, Rare diseases, Neuronal diseases, Skin diseases, Fetal diseases

Aliases & Classifications for Legius Syndrome

MalaCards integrated aliases for Legius Syndrome:

Name: Legius Syndrome 53 23 49 24 55 71 36 28 13
Neurofibromatosis Type 1-Like Syndrome 53 23 24
Nfls 53 24 71
Neurofibromatosis 1-Like Syndrome 55 71
Neurofibromatosis Type 1-Like Syndrome; Nfls 53
Neurofibromatosis, Type 1-Like Syndrome 69
Neurofibromatosis Type 1 Like Syndrome 49
Cafe-Au-Lait Spots 41
Nf1-Like Syndrome 55
Cafe-Au-Lait Spot 28


Orphanet epidemiological data:

legius syndrome
Inheritance: Autosomal dominant; Prevalence: 1-9/100000 (Worldwide); Age of onset: Childhood,Infancy,Neonatal; Age of death: normal life expectancy;


autosomal dominant

some patients do not have dysmorphic features
phenotypic overlap with neurofibromatosis 1 (nf1, )


legius syndrome:
Inheritance autosomal dominant inheritance


Penetrance The vast majority of individuals with spred1 pathogenic variants have café au lait macules and/or freckling; however, the age of pigment penetrance is not established. only two individuals (a 60-year-old male and a 2-year-old child), each with a presumed spred1 pathogenic variant, were reported not to have café au lait macules or freckling [brems et al 2007, messiaen et al 2009]...


External Ids:

OMIM 53 611431
Orphanet 55 ORPHA137605
MESH via Orphanet 42 C548032
UMLS via Orphanet 70 C1969623
ICD10 via Orphanet 33 Q85.0
MedGen 39 C1969623
MeSH 41 D019080
KEGG 36 H01986
UMLS 69 C1969623

Summaries for Legius Syndrome

NIH Rare Diseases : 49 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 137605Disease definitionLegius syndrome, also known as NF1-like syndrome, is a rare, genetic skin pigmentation disorder characterized by multiple café-au-lait macules with or without axillary or inguinal freckling.EpidemiologyThe prevalence of Legius syndrome is not known. Fewer than 200 cases have been reported to date. Prevalence may be higher than expected due to misdiagnosis of cases as neurofibromatosis type 1 (NF1, see this term). The incidence of NF1 is reported to be 1/3000, and about 2% of patients fulfilling diagnostic criteria for NF1 are found to have the genetic mutation underlying Legius syndrome (SPRED1).Clinical descriptionThe clinical presentation of Legius syndrome is very similar to that of NF1. Patients typically present with multiple café-au-lait spots sometimes associated with intertriginous freckling, but lack Lisch nodules, optic pathway gliomas, bone abnormalities, neurofibromas or other tumor manifestations. The number of café-au-lait macules tends to increase with age during childhood. Other less common manifestations include short stature, macrocephaly, Noonan-like facies, pectus excavatum/carinatum, lipomas, hypopigmented macules, vascular lesions, learning disabilities, attention deficit/hyperactivity disorder (ADHD), and developmental delay.EtiologyLegius syndrome is caused by heterozygous inactivating mutations in the SPRED1 gene (15q14), involved in regulation of the RAS-MAPK signal transduction pathway. Nearly 100 different mutations in this gene have been identified. The proportion of cases related to de novo mutations is not yet known. No genotype-phenotype correlations have been found.Diagnostic methodsAbout 50% of patients with Legius syndrome fulfill the diagnostic criteria for NF1, but they have a far milder phenotype compared to NF1 patients. Diagnosis based solely on the presence of clinical features is difficult, given the overlap with other disorders characterized by multiple café-au-lait spots. The presence of characteristic clinical signs in parents of affected individuals is supportive of diagnosis. However, molecular genetic testing is required to confirm the diagnosis and testing is available on a clinical basis.Differential diagnosisLegius syndrome is differentiated from NF1 by the absence of the non-pigmentary clinical manifestations seen in this disorder (i.e. Lisch nodules, neurofibromas, optic glioma, bone abnormalities). Correct diagnosis is essential because of the differences in prognosis and long-term monitoring between Legius syndrome and NF1. Other disorders to consider include Noonan syndrome, Noonan syndrome with lentigines (LEOPARD syndrome), and McCune-Albright syndrome (see these terms).Antenatal diagnosisPrenatal diagnosis is possible and requires prior identification of the disease-causing mutation in the family.Genetic counselingLegius syndrome follows an autosomal dominant pattern of inheritance. Genetic counseling should be provided to affected families.Management and treatmentDrug therapy should be considered for the behavioral manifestations of the disorder (ADHD). Physical, speech, and occupational therapy is recommended for those with developmental delay and educational support for those with learning difficulties.PrognosisGiven the current knowledge of disease manifestations and complications, the prognosis for patients with Legius syndrome is considered to be very good.Visit the Orphanet disease page for more resources. Last updated: 7/2/2014

MalaCards based summary : Legius Syndrome, also known as neurofibromatosis type 1-like syndrome, is related to noonan syndrome 1 and neurofibromatosis, type iv, of riccardi, and has symptoms including macrocephaly, hypertelorism and short neck. An important gene associated with Legius Syndrome is SPRED1 (Sprouty Related EVH1 Domain Containing 1), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Negative regulation of FGFR3 signaling. Affiliated tissues include skin, bone and testes, and related phenotypes are craniofacial and limbs/digits/tail

Genetics Home Reference : 24 Legius syndrome is a condition characterized by changes in skin coloring (pigmentation). Almost all affected individuals have multiple café-au-lait spots, which are flat patches on the skin that are darker than the surrounding area. Another pigmentation change, freckles in the armpits and groin, may occur in some affected individuals.

OMIM : 53 Legius syndrome is an autosomal dominant disorder that shows some similarities to neurofibromatosis type I (NF1; 162200), which is caused by mutation in the neurofibromin gene (613113); however, Legius syndrome is less severe. Individuals with Legius syndrome typically have multiple cafe-au-lait spots, sometimes associated with skin fold freckling, variable dysmorphic features such as hypertelorism or macrocephaly, lipomas, and mild learning disabilities or attention problems. Legius syndrome is not associated with neurofibromas, optic gliomas, Lisch nodules, or tumor predisposition. The SPRED1 gene encodes a negative regulator of the RAS-MAPK pathway, similar to neurofibromin, and thus may be considered a RASopathy (review by Brems et al., 2012). (611431)

UniProtKB/Swiss-Prot : 71 Neurofibromatosis 1-like syndrome: A disorder characterized mainly by cafe au lait macules without neurofibromas or other tumor manifestations of neurofibromatosis type 1, axillary freckling, and macrocephaly. Additional clinical manifestations include Noonan-like facial dysmorphism, lipomas, learning disabilities and attention deficit-hyperactivity.

Wikipedia : 72 Legius syndrome (LS) is an autosomal dominant condition characterized by cafe au lait spots. It was... more...

GeneReviews: NBK47312

Related Diseases for Legius Syndrome

Diseases related to Legius Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
# Related Disease Score Top Affiliating Genes
1 noonan syndrome 1 31.5 NF1 PTPN11 SPRED1
2 neurofibromatosis, type iv, of riccardi 29.2 MSH2 MSH6 NF1 PTPN11
3 cafe-au-lait spots, multiple 12.8
4 watson syndrome 12.4
5 neurofibromatosis, type i 11.0
6 plexiform neurofibroma 10.4 NF1 SPRED1
7 adrenal cortical adenocarcinoma 10.2 SPRY1 SPRY2
8 neurofibromatosis-noonan syndrome 10.2 NF1 PTPN11
9 pulmonary valve stenosis 10.2 PTPN11 SPRED1
10 pulmonary valve disease 10.2 PTPN11 SPRED1
11 deafness, autosomal recessive 26 10.2 PTPN11 SPRY2
12 myelodysplastic myeloproliferative cancer 10.2 NF1 PTPN11
13 pulmonic stenosis 10.1 NF1 PTPN11
14 leopard syndrome 10.0 NF1 PTPN11 SPRED1
15 cardiofaciocutaneous syndrome 1 10.0 PTPN11 SPRED1
16 amyotrophic lateral sclerosis 1 10.0
17 lateral sclerosis 10.0
18 juvenile myelomonocytic leukemia 10.0 NF1 PTPN11 SPRED1
19 neuronitis 9.9
20 encephalopathy 9.9
21 choroiditis 9.9
22 autosomal dominant café au lait spots 9.8 NF1 PTPN11 SPRED1 SPRED2
23 appendix carcinoid tumor 9.8 MSH2 MSH6
24 adenosquamous colon carcinoma 9.8 MSH2 MSH6
25 hydrocephalus, normal-pressure 9.8
26 charcot-marie-tooth disease 9.8
27 hydrocephalus 9.8
28 tooth disease 9.8
29 substance abuse 9.8
30 retinitis 9.8
31 craniopharyngioma 9.8
32 neuropathy 9.8
33 glioma 9.8
34 head injury 9.8
35 subcortical arteriosclerotic encephalopathy 9.8
36 sebaceous adenoma 9.8 MSH2 MSH6
37 attenuated familial adenomatous polyposis 9.8 MSH2 MSH6
38 lynch syndrome i 9.7 MSH2 MSH6
39 cecum adenocarcinoma 9.7 MSH2 MSH6
40 sebaceous adenocarcinoma 9.6 MSH2 MSH6
41 small intestine cancer 9.6 MSH2 MSH6
42 muir-torre syndrome 9.6 MSH2 MSH6
43 autosomal genetic disease 9.6 MSH2 MSH6 NF1
44 autosomal dominant disease 9.6 MSH2 MSH6 NF1
45 skin benign neoplasm 9.5 MSH2 MSH6
46 hereditary breast ovarian cancer syndrome 9.4 MSH2 MSH6
47 mismatch repair cancer syndrome 9.3 MSH2 MSH6

Graphical network of the top 20 diseases related to Legius Syndrome:

Diseases related to Legius Syndrome

Symptoms & Phenotypes for Legius Syndrome

Symptoms via clinical synopsis from OMIM:

Head And Neck Eyes:
downslanting palpebral fissures
epicanthal folds

Skin Nails Hair Hair:
low posterior hairline

Neurologic Central Nervous System:
no neurofibromas
learning difficulties

Head And Neck Ears:
low-set posteriorly rotated ears

Chest RibsSternum Clavicles And Scapulae:
pectus deformities (in some patients)

Head And Neck Face:
noonan-like facies in a minority of patients
triangular face with age

Head And Neck Mouth:
short neck
high arched palate
deeply grooved philtrum
high peaks of upper lip vermilion border

Muscle Soft Tissue:

Skin Nails Hair Skin:
cafe-au-lait spots
axillary freckling

Neurologic Behavioral Psychiatric Manifestations:
attention deficit-hyperactivity

Head And Neck Head:
macrocephaly (less common)

Clinical features from OMIM:


Human phenotypes related to Legius Syndrome:

31 (show all 19)
# Description HPO Frequency HPO Source Accession
1 macrocephaly 31 HP:0000256
2 hypertelorism 31 HP:0000316
3 short neck 31 HP:0000470
4 ptosis 31 HP:0000508
5 micrognathia 31 HP:0000347
6 epicanthus 31 HP:0000286
7 attention deficit hyperactivity disorder 31 HP:0007018
8 specific learning disability 31 HP:0001328
9 low posterior hairline 31 HP:0002162
10 high, narrow palate 31 HP:0002705
11 multiple lipomas 31 HP:0001012
12 low-set, posteriorly rotated ears 31 HP:0000368
13 downslanted palpebral fissures 31 HP:0000494
14 triangular face 31 HP:0000325
15 abnormality of the sternum 31 occasional (7.5%) HP:0000766
16 cafe-au-lait spot 31 HP:0000957
17 generalized hypotonia 31 HP:0001290
18 neurofibromas 31 HP:0001067
19 axillary freckling 31 HP:0000997

MGI Mouse Phenotypes related to Legius Syndrome:

# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.65 NF1 PTPN11 SPRED1 SPRY2 SPRY4
2 limbs/digits/tail MP:0005371 9.63 NF1 PTPN11 SPRED1 SPRED2 SPRY2 SPRY4
3 neoplasm MP:0002006 9.43 MSH2 MSH6 NF1 PTPN11 SPRY1 SPRY2
4 respiratory system MP:0005388 9.02 NF1 PTPN11 SPRED1 SPRY2 SPRY4

Drugs & Therapeutics for Legius Syndrome

Interventional clinical trials:

# Name Status NCT ID Phase Drugs
1 Study of Disease Severity in Adults With Neurofibromatosis Type 1 (NF1) Active, not recruiting NCT00111384

Search NIH Clinical Center for Legius Syndrome

Cochrane evidence based reviews: cafe-au-lait spots

Genetic Tests for Legius Syndrome

Genetic tests related to Legius Syndrome:

# Genetic test Affiliating Genes
1 Legius Syndrome 28 SPRED1
2 Cafe-Au-Lait Spot 28

Anatomical Context for Legius Syndrome

MalaCards organs/tissues related to Legius Syndrome:

Skin, Bone, Testes

Publications for Legius Syndrome

Articles related to Legius Syndrome:

(show all 24)
# Title Authors Year
The absence that makes the difference: choroidal abnormalities in Legius syndrome. ( 28747691 )
Legius syndrome: A case report. ( 28378438 )
The first Slovak Legius syndrome patient carrying the SPRED1 gene mutation. ( 28150585 )
Interaction between a Domain of the Negative Regulator of the Ras-ERK Pathway, SPRED1 Protein, and the GTPase-activating Protein-related Domain of Neurofibromin Is Implicated in Legius Syndrome and Neurofibromatosis Type 1. ( 26635368 )
Legius syndrome: case report and review of literature. ( 25883013 )
Legius Syndrome: two novel mutations in the SPRED1 gene. ( 27081556 )
Family with Legius syndrome (neurofibromatosis type 1-like syndrome). ( 25981987 )
SPRED1, a RAS MAPK pathway inhibitor that causes Legius syndrome, is a tumour suppressor downregulated in paediatric acute myeloblastic leukaemia. ( 24469042 )
Legius Syndrome, an Update.Molecular Pathology of Mutations in SPRED1. ( 24334617 )
A shared molecular mechanism underlies the human rasopathies Legius syndrome and Neurofibromatosis-1. ( 22751498 )
CafAc-au-lait macules and intertriginous freckling in piebaldism: clinical overlap with neurofibromatosis type 1 and Legius syndrome. ( 22438235 )
Review and update of SPRED1 mutations causing Legius syndrome. ( 22753041 )
Observations on intelligence and behavior in 15 patients with Legius syndrome. ( 21495177 )
The SPRED1 Variants Repository for Legius Syndrome. ( 22384355 )
Identification of five novel SPRED1 germline mutations in Legius syndrome. ( 21649642 )
Legius syndrome in fourteen families. ( 21089071 )
Novel human pathological mutations. Gene symbol: SPRED1. Disease: Legius syndrome. ( 20108386 )
Novel human pathological mutations. Gene symbol: SPRED1. Disease: Legius syndrome. ( 20108421 )
Novel human pathological mutations. Gene symbol: SPRED1. Disease: Legius syndrome. ( 20108422 )
Novel human pathological mutations. Gene symbol: SPRED1. Disease: Legius syndrome. ( 20108420 )
Novel human pathological mutations. Gene symbol: SPRED1. Disease: Legius syndrome. ( 20108385 )
SPRED1 mutations (Legius syndrome): another clinically useful genotype for dissecting the neurofibromatosis type 1 phenotype. ( 19443465 )
Pigmentary findings in neurofibromatosis type 1-like syndrome (Legius syndrome): potential diagnostic dilemmas. ( 19920242 )
Legius Syndrome ( 20945555 )

Variations for Legius Syndrome

UniProtKB/Swiss-Prot genetic disease variations for Legius Syndrome:

# Symbol AA change Variation ID SNP ID
1 SPRED1 p.Trp31Cys VAR_064827
2 SPRED1 p.Val44Asp VAR_064828 rs121434318

ClinVar genetic disease variations for Legius Syndrome:

6 (show all 18)
# Gene Variation Type Significance SNP ID Assembly Location
1 SPRED1 SPRED1, 2-BP DEL, 1045AG deletion Pathogenic
2 NF1 NM_000267.3(NF1): c.2041C> T (p.Arg681Ter) single nucleotide variant Pathogenic rs768638173 GRCh37 Chromosome 17, 29553492: 29553492
3 SPRED1 NM_152594.2(SPRED1): c.349C> T (p.Arg117Ter) single nucleotide variant Pathogenic rs121434312 GRCh37 Chromosome 15, 38614583: 38614583
4 SPRED1 NM_152594.2(SPRED1): c.70C> T (p.Arg24Ter) single nucleotide variant Pathogenic rs121434313 GRCh37 Chromosome 15, 38591611: 38591611
5 SPRED1 SPRED1, IVS5DS, G-A, +1 single nucleotide variant Pathogenic
6 SPRED1 NM_152594.2(SPRED1): c.643C> T (p.Gln215Ter) single nucleotide variant Pathogenic rs121434314 GRCh37 Chromosome 15, 38641683: 38641683
7 SPRED1 NM_152594.2(SPRED1): c.190C> T (p.Arg64Ter) single nucleotide variant Pathogenic rs121434315 GRCh37 Chromosome 15, 38591731: 38591731
8 SPRED1 NM_152594.2(SPRED1): c.637C> T (p.Gln213Ter) single nucleotide variant Pathogenic rs121434316 GRCh37 Chromosome 15, 38641677: 38641677
9 SPRED1 NM_152594.2(SPRED1): c.784A> T (p.Arg262Ter) single nucleotide variant Pathogenic rs121434317 GRCh37 Chromosome 15, 38643314: 38643314
10 SPRED1 NM_152594.2(SPRED1): c.131T> A (p.Val44Asp) single nucleotide variant Pathogenic rs121434318 GRCh37 Chromosome 15, 38591672: 38591672
11 SPRED1 NM_152594.2(SPRED1): c.796_797delAT (p.Met266Valfs) deletion Pathogenic rs864622410 GRCh37 Chromosome 15, 38643326: 38643327
12 SPRED1 NM_152594.2(SPRED1): c.1151_1152delAG (p.Glu384Glyfs) deletion Pathogenic rs878855228 GRCh37 Chromosome 15, 38643681: 38643682
13 SPRED1 NM_152594.2(SPRED1): c.973C> T (p.Arg325Ter) single nucleotide variant Pathogenic rs1057518683 GRCh38 Chromosome 15, 38351302: 38351302
14 SPRED1 NC_000015.10: g.(?_38299373)_(38357249_?)del deletion Pathogenic GRCh37 Chromosome 15, 38591574: 38649450
15 SPRED1 NM_152594.2(SPRED1): c.421C> T (p.Gln141Ter) single nucleotide variant Pathogenic rs1060502505 GRCh38 Chromosome 15, 38324807: 38324807
16 SPRED1 NM_152594.2(SPRED1): c.1196dup (p.Phe400Valfs) duplication Likely pathogenic GRCh38 Chromosome 15, 38351525: 38351525
17 SPRED1 NM_152594.2(SPRED1): c.923_924delCT (p.Ser308Cysfs) deletion Pathogenic GRCh37 Chromosome 15, 38643453: 38643454
18 SPRED1 NM_152594.2(SPRED1): c.1099_1102delAGTT (p.Ser367Alafs) deletion Pathogenic GRCh37 Chromosome 15, 38643629: 38643632

Copy number variations for Legius Syndrome from CNVD:

# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 91538 15 31400000 37900000 Copy number SPRED1 Legius syndrome

Expression for Legius Syndrome

Search GEO for disease gene expression data for Legius Syndrome.

Pathways for Legius Syndrome

Pathways related to Legius Syndrome according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
Show member pathways
Show member pathways
5 11.73 MSH2 MSH6 NF1
6 11.66 SPRED1 SPRY1 SPRY2
Show member pathways
8 11.17 PTPN11 SPRY2
9 11.14 MSH2 MSH6
10 10.98 NF1 PTPN11 SPRY1 SPRY2
11 10.9 MSH2 MSH6

GO Terms for Legius Syndrome

Cellular components related to Legius Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MutSalpha complex GO:0032301 8.62 MSH2 MSH6

Biological processes related to Legius Syndrome according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.87 SPRED1 SPRED2 SPRED3 SPRY1 SPRY2 SPRY3
2 fibroblast growth factor receptor signaling pathway GO:0008543 9.71 PTPN11 SPRED1 SPRED2
3 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.64 MSH2 MSH6
4 regulation of MAPK cascade GO:0043408 9.63 NF1 SPRED1
5 negative regulation of GTPase activity GO:0034260 9.63 SPRY1 SPRY2
6 metanephros development GO:0001656 9.62 NF1 SPRY1
7 mismatch repair GO:0006298 9.62 MSH2 MSH6
8 negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 9.61 SPRY1 SPRY2
9 inactivation of MAPK activity GO:0000188 9.61 SPRED1 SPRED2
10 negative regulation of MAPK cascade GO:0043409 9.6 NF1 SPRED1
11 establishment of mitotic spindle orientation GO:0000132 9.59 SPRY1 SPRY2
12 somatic hypermutation of immunoglobulin genes GO:0016446 9.58 MSH2 MSH6
13 isotype switching GO:0045190 9.58 MSH2 MSH6
14 negative regulation of fibroblast growth factor receptor signaling pathway GO:0040037 9.57 SPRY1 SPRY2
15 determination of adult lifespan GO:0008340 9.56 MSH2 MSH6
16 positive regulation of DNA damage response, signal transduction by p53 class mediator GO:0043517 9.55 SPRED1 SPRED2
17 negative regulation of Ras protein signal transduction GO:0046580 9.54 NF1 SPRY1 SPRY2
18 bud elongation involved in lung branching GO:0060449 9.52 SPRY1 SPRY2
19 positive regulation of helicase activity GO:0051096 9.51 MSH2 MSH6
20 negative regulation of DNA recombination GO:0045910 9.49 MSH2 MSH6
21 maintenance of DNA repeat elements GO:0043570 9.48 MSH2 MSH6
22 somatic recombination of immunoglobulin gene segments GO:0016447 9.46 MSH2 MSH6
23 negative regulation of ERK1 and ERK2 cascade GO:0070373 9.46 SPRED1 SPRY1 SPRY2 SPRY4
24 negative regulation of neurotrophin TRK receptor signaling pathway GO:0051387 9.43 SPRY1 SPRY2
25 negative regulation of peptidyl-threonine phosphorylation GO:0010801 9.43 SPRED1 SPRED2 SPRY2
26 regulation of protein deacetylation GO:0090311 9.4 SPRED1 SPRED2
27 negative regulation of MAP kinase activity GO:0043407 9.26 NF1 SPRY1 SPRY2 SPRY4
28 regulation of signal transduction GO:0009966 9.17 SPRED1 SPRED2 SPRED3 SPRY1 SPRY2 SPRY3

Molecular functions related to Legius Syndrome according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.78 MSH2 SPRED1 SPRED2 SPRY2
2 DNA-dependent ATPase activity GO:0008094 9.51 MSH2 MSH6
3 ADP binding GO:0043531 9.49 MSH2 MSH6
4 four-way junction DNA binding GO:0000400 9.46 MSH2 MSH6
5 mismatched DNA binding GO:0030983 9.43 MSH2 MSH6
6 oxidized purine DNA binding GO:0032357 9.4 MSH2 MSH6
7 MutLalpha complex binding GO:0032405 9.37 MSH2 MSH6
8 guanine/thymine mispair binding GO:0032137 9.32 MSH2 MSH6
9 single guanine insertion binding GO:0032142 9.26 MSH2 MSH6
10 stem cell factor receptor binding GO:0005173 9.16 SPRED1 SPRED2
11 single thymine insertion binding GO:0032143 8.96 MSH2 MSH6
12 protein serine/threonine kinase inhibitor activity GO:0030291 8.8 SPRED1 SPRED2 SPRY2

Sources for Legius Syndrome

9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
51 Novoseek
54 OMIM via Orphanet
58 PubMed
66 SNOMED-CT via Orphanet
68 Tocris
70 UMLS via Orphanet
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