MCID: LMY002
MIFTS: 69

Leiomyoma malady

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Summaries for Leiomyoma

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Wikipedia:65 A leiomyoma (plural leiomyomas or leiomyomata) (leio- + myo- + -oma, \"smooth-muscle tumor\") is a... more...

MalaCards based summary: Leiomyoma, also known as leiomyomatous neoplasm, is related to leiomyomatosis and uterine sarcoma. An important gene associated with Leiomyoma is DES (desmin), and among its related pathways are MNAR-PELP1 and Estrogen Receptor Interaction and Striated Muscle Contraction. The drugs leuprolide and leuprolide acetate and the compounds idoxifene and goserelin have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, uterus and lung, and related mouse phenotypes are limbs/digits/tail and adipose tissue.

Disease Ontology:8 A cell type benign neoplasm that is a benign tumor of smooth muscle cells.

Aliases & Classifications for Leiomyoma

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 34MeSH, 57SNOMED-CT, 39NCIt
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Leiomyoma, Aliases & Descriptions:

Name: Leiomyoma 8 10 44
Leiomyomatous Neoplasm 8 62
 
Leiomyomatous Tumor 8 62
Fibroid Tumor 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:127
MeSH34 D007889
NCIt39 C3157

Related Diseases for Leiomyoma

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Diseases related to Leiomyoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 320)
idRelated DiseaseScoreTop Affiliating Genes
1leiomyomatosis31.2GNRH1, PGR, ESR1, FH
2uterine sarcoma31.0CYP19A1, DES, ESR1
3lymphangioleiomyomatosis31.0DES, PGR, ESR1
4uterine fibroid30.9GNRH1, PGR, ESR1, FH, HMGA2
5myoma30.9DES, MYOG
6gastrointestinal stromal tumor30.8DES, VIM, ACTC1, PCNA, S100A1
7lipoma30.6DES, S100A1, HMGA2
8ovarian cyst30.5ESR2, GNRH1, CYP19A1
9sarcoma30.5DES, VIM, MYOG, ACTC1, S100A1, HMGA2
10breast cancer30.5CYP19A1, PGR, ESR2, ESR1
11gynecomastia30.5ESR1, PGR, GNRH1, CYP19A1
12liposarcoma30.5HMGA2, VIM, DES
13chondroma30.4HMGA2
14leiomyosarcoma30.4S100A1, FH, ACTC1, CCL11, MYOG, VIM
15desmoid tumor30.4DES, ACTC1
16infertility30.4CYP19A1, GNRH1, ESR2, ESR1
17malignant mixed mullerian tumor30.3VIM, ESR1, PGR
18paraganglioma30.3DES, VIM, ACTC1, S100A1
19fibrous histiocytoma30.3DES, VIM, ACTC1
20neurofibroma30.1S100A1, ACTC1, VIM
21endometrial stromal sarcoma30.1ACTC1, VIM, ESR1, ESR2, PGR, CYP19A1
22pituitary tumors30.0GNRH1, ESR2, ESR1
23hemangiopericytoma30.0S100A1, ACTC1, VIM, DES
24fibroma30.0DES, VIM, ACTC1, S100A1
25neurilemmoma30.0S100A1, ACTC1, VIM, DES
26adenoma30.0GNRH1, ESR2, ACTC1, PCNA, S100A1, HMGA2
27choriocarcinoma29.8ADM, ESR2, GNRH1, CYP19A1
28pituitary adenoma29.7HMGA2, PCNA, ADM, ESR2, GNRH1
29fibromatosis29.7DES, TGFB3, PGR, VIM, ACTC1, S100A1
30smooth muscle tumor29.6DES, HMGA2, S100A1, PCNA, ACTC1, CCL11
31osteosarcoma29.5TGFB3, ESR2, ESR1, OXTR, HMGA2
32wilms tumor29.4DES, CYR61, VIM, MYOG, ACTC1
33endometriosis29.3OXTR, ESR1, ESR2, PGR, GNRH1, CYP19A1
34lung cancer29.0CYR61, ESR2, OXTR, PCNA, S100A1, HMGA2
35melanoma28.8DES, CYR61, TGFB3, VIM, CCL11, ACTC1
36adenocarcinoma28.5CYR61, TGFB3, PGR, ESR2, ESR1, VIM
37benign metastasizing leiomyoma10.8
38gastric leiomyoma10.8
39bladder leiomyoma10.6
40infantile myofibromatosis10.6DES
41bizarre leiomyoma10.6
42esophagitis10.6
43adenomyosis10.6
44leiomyoma cutis10.5
45syringoma10.5S100A1
46cerebral meningioma10.5PGR
47fasciitis10.5ACTC1
48progesterone resistance10.5PGR, ESR1
49breast fibroadenoma10.5PGR, ESR1
50endobronchial leiomyoma10.5

Graphical network of the top 20 diseases related to Leiomyoma:



Diseases related to leiomyoma

Symptoms for Leiomyoma

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Drugs & Therapeutics for Leiomyoma

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Drug clinical trials:

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Search NIH Clinical Center for Leiomyoma

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Leiomyoma

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Anatomical Context for Leiomyoma

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MalaCards organs/tissues related to Leiomyoma:

32
Smooth muscle, Uterus, Lung, Breast, Prostate, Ovary, Endothelial, Colon, Small intestine, Liver, Placenta, Trachea, Kidney, Testis, Bone, Lymph node, Spleen, Heart, Thyroid, Adrenal gland, Cervix, Myeloid, B cells, Pituitary, Skeletal muscle, Brain, Spinal cord, Adipocyte, Pancreas, Salivary gland, Testes, T cells, B lymphoblasts

Animal Models for Leiomyoma or affiliated genes

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MGI Mouse Phenotypes related to Leiomyoma:

36 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053719.2HMGA2, ESR1, ESR2, PGR, TGFB3
2MP:00053758.6CYP19A1, ESR2, ESR1, MYOG, PCNA, HMGA2
3MP:00053908.4CYP19A1, GNRH1, TGFB3, PGR, ESR2, ESR1
4MP:00053888.3TGFB3, ESR2, ESR1, VIM, MYOG, ADM
5MP:00053798.3CYP19A1, GNRH1, PGR, ESR2, ESR1, OXTR
6MP:00053708.1CYR61, CYP19A1, GNRH1, ESR2, ESR1, ADM
7MP:00107718.0CYP19A1, GNRH1, PGR, ESR2, ESR1, MYOG
8MP:00036317.9CYP19A1, GNRH1, TGFB3, ESR2, ESR1, VIM
9MP:00053977.8CYP19A1, GNRH1, PGR, ESR2, ESR1, VIM
10MP:00053807.8CYR61, TGFB3, PGR, ESR1, VIM, MYOG
11MP:00053877.8CYP19A1, GNRH1, PGR, ESR2, ESR1, VIM
12MP:00053897.7ESR2, PGR, GNRH1, CYP19A1, ESR1, VIM
13MP:00053847.5CYR61, CYP19A1, TGFB3, PGR, ESR2, ESR1
14MP:00053787.4CYP19A1, GNRH1, ESR2, ESR1, VIM, MYOG
15MP:00028737.2PGR, TGFB3, GNRH1, CYP19A1, ESR2, MYOG
16MP:00053697.2S100A1, DES, CYP19A1, PGR, ESR2, ESR1
17MP:00053857.0DES, CYR61, CYP19A1, TGFB3, PGR, ESR2
18MP:00053866.9DES, CYP19A1, TGFB3, PGR, ESR2, ESR1
19MP:00107686.5ESR2, PGR, TGFB3, CYR61, DES, ESR1
20MP:00053766.4PGR, TGFB3, GNRH1, CYP19A1, CYR61, DES

Publications for Leiomyoma

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Articles related to Leiomyoma:

(show top 50)    (show all 1368)
idTitleAuthorsYear
1
Simvastatin Potently Induces Calcium-Dependent Apoptosis of Human Leiomyoma Cells. (25359773)
2014
2
Leiomyomas beyond the uterus; benign metastasizing leiomyomatosis with paraaortic metastasizing endometriosis and intravenous leiomyomatosis: a case series and review of the literature. (25047270)
2014
3
Giant leiomyoma of the retzius space: a case report. (23585976)
2013
4
Angiomatous leiomyoma of the urachus: A rare entity masquerading as extraluminal gastrointestinal stromal tumor. (24049386)
2013
5
Human prolyl hydroxylase expression in uterine leiomyoma during the menstrual cycle. (23241241)
2012
6
Gonadotropin-releasing hormone (GnRH) agonist leuprolide acetate and GnRH antagonist cetrorelix acetate directly inhibit leiomyoma extracellular matrix production. (22901846)
2012
7
Effect of the aromatase inhibitor anastrozole on uterine and leiomyoma Doppler blood flow in patients scheduled for hysterectomy: a pilot study. (22102490)
2012
8
Leiomyoma of the Round Ligament of the Uterus: Case report and review of literature. (22912930)
2012
9
Obstructive uropathy secondary to uterine leiomyoma in a chimpanzee (Pan troglodytes). (23561890)
2012
10
Cystoscopic enucleation of bladder leiomyoma. (22346100)
2012
11
Hypoxia: the driving force of uterine myometrial stem cells differentiation into leiomyoma cells. (21903341)
2011
12
Massive Uterine Leiomyoma in a Patient with Friedreich's Ataxia: Is There a Possible Association? (21869894)
2011
13
MAPK14 cooperates with MAPK3/1 to regulate endothelin-1-mediated prostaglandin synthase 2 induction and survival in leiomyoma but not in normal myometrial cells. (21084714)
2011
14
Carcinosarcoma arising in a uterine leiomyoma: report of a unique neoplasm. (21979594)
2011
15
Resolution of eosinophilic gastroenteritis after resection of uterine leiomyomas. (22009412)
2011
16
Leiomyoma of the urinary bladder: a series of nine cases and review of the literature. (20947147)
2010
17
Submucosal uterine leiomyomas have a global effect on molecular determinants of endometrial receptivity. (18555231)
2010
18
Progesterone is essential for maintenance and growth of uterine leiomyoma. (20375184)
2010
19
Progesterone receptor action in leiomyoma and endometrial cancer. (20374701)
2009
20
Estrogen receptor alpha-351 XbaI*G and -397 PvuII*C-related genotypes and alleles are associated with higher susceptibilities of endometriosis and leiomyoma. (17121748)
2007
21
A novel selective progesterone receptor modulator asoprisnil activates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated signaling pathway in cultured human uterine leiomyoma cells in the absence of comparable effects on myometrial cells. (17105846)
2007
22
Value of dynamic enhanced magnetic resonance imaging for distinguishing between ovarian fibroma and subserous uterine leiomyoma. (17414760)
2007
23
Color Doppler imaging and 3-dimensional sonographic findings of urinary bladder leiomyoma. (17460009)
2007
24
Progesterone receptor regulates Bcl-2 gene expression through direct binding to its promoter region in uterine leiomyoma cells. (17785366)
2007
25
Early growth response gene-1 plays a pivotal role in down-regulation of a cohort of genes in uterine leiomyoma. (17975260)
2007
26
Interleukin-6 -174G/C polymorphism in breast cancer and uterine leiomyoma patients: a population-based case control study. (18199986)
2007
27
Predictive value of magnetic resonance imaging in differentiating between leiomyoma and adenomyosis. (16882423)
2006
28
Ethnic distribution of estrogen receptor-alpha polymorphism is associated with a higher prevalence of uterine leiomyomas in black Americans. (16860797)
2006
29
Skeletal muscle-like and rhabdoid cells in uterine leiomyomas. (16175075)
2005
30
Combination of uterine adenomyosis with leiomyoma]. (16075610)
2005
31
Anterior orbital leiomyoma: possible pulley smooth muscle tissue tumor. (16286632)
2005
32
Bcl-2 receptor expression in patients with uterine smooth muscle tumors: an immunohistochemical analysis comparing leiomyoma, uterine smooth muscle tumor of uncertain malignant potential, and leiomyosarcoma. (15051039)
2004
33
An unusual gestational choriocarcinoma occurring primarily on the surface of a subserous leiomyoma. (14723763)
2004
34
Expression, menstrual cycle-dependent activation, and bimodal mitogenic effect of transforming growth factor-beta1 in human myometrium and leiomyoma. (12548199)
2003
35
A benefit-risk assessment of medical treatment for uterine leiomyomas. (12222988)
2002
36
Estrogen receptor-alpha and -beta expression in microvascular endothelial cells and smooth muscle cells of myometrium and leiomyoma. (12149410)
2002
37
Recurrent bladder leiomyoma with ovarian steroid hormone receptors. (11832749)
2002
38
Non-puerperal uterine inversion associated with an atypical leiomyoma. (11284635)
2001
39
Retroperitoneal leiomyomas: a clinicopathologic and immunohistochemical study of 56 cases with a comparison to retroperitoneal leiomyosarcomas. (11684951)
2001
40
Comparative analysis of cyclin D1 and oestrogen receptor (alpha and beta) levels in human leiomyoma and adjacent myometrium. (11675476)
2001
41
Bizarre leiomyoma of the epididymis. A case report. (11517827)
2000
42
Transforming growth factor-beta3 is expressed at high levels in leiomyoma where it stimulates fibronectin expression and cell proliferation. (10785229)
2000
43
Cellular leiomyoma mimicking endometrial stromal neoplasm in association with GnRH agonist goserelin. (10064405)
1999
44
Expression and imprinting of insulin-like growth factor II (IGF2) and H19 genes in uterine leiomyomas. (10479496)
1999
45
Genomic and functional map of the chromosome 14 t(12;14) breakpoint cluster region in uterine leiomyoma. (9740667)
1998
46
Laparoscopic intragastric surgery for gastric leiomyoma. (9079613)
1997
47
Calcified leiomyoma of deep soft tissue. Report of a case in childhood. (7952507)
1994
48
Endobronchial leiomyoma. (8500802)
1993
49
Urinary bladder leiomyoma: magnetic resonance imaging findings. (1290211)
1992
50
Giant esophageal leiomyoma with secondary megaesophagus. (1257906)
1976

Variations for Leiomyoma

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Expression for genes affiliated with Leiomyoma

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Expression patterns in normal tissues for genes affiliated with Leiomyoma

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Pathways for genes affiliated with Leiomyoma

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Compounds for genes affiliated with Leiomyoma

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Compounds related to Leiomyoma according to GeneCards/GeneDecks:

(show top 50)    (show all 185)
idCompoundScoreTop Affiliating Genes
1idoxifene449.9CYP19A1, ESR1, PGR
2goserelin44 28 1111.9CYP19A1, GNRH1, PGR, ESR1
3nandrolone44 2410.8ESR2, ESR1, CYP19A1, PGR
4exemestane44 50 61 1112.7PGR, CYP19A1, ESR2, ESR1
5anastrozole44 50 1111.7ESR2, PGR, CYP19A1, ESR1
6bisphenol a449.6PGR, CYP19A1, ESR2, ESR1
7estradiol benzoate449.6PGR, CYP19A1, ESR1, GNRH1, ESR2
8clomiphene citrate449.6ESR1, ESR2, PGR, GNRH1, CYP19A1
9toremifene44 1110.6GNRH1, PGR, ESR2, ESR1, CYP19A1
10reticulin449.5VIM, DES, PCNA, ACTC1
11tibolone449.5GNRH1, ESR1, CYP19A1, PGR
12diethylstilbestrol44 28 1111.5CYP19A1, GNRH1, ESR1, ESR2, PGR
13progestins449.5ESR1, PGR, GNRH1, ESR2, CYP19A1
14mucicarmine449.4VIM, ACTC1, S100A1, DES
15danazol44 24 1111.4CYP19A1, PCNA, PGR, GNRH1, ESR1
16leuprolide acetate449.3ESR1, ESR2, PGR, TGFB3, GNRH1, CYP19A1
17fulvestrant44 50 28 1112.3PCNA, ESR1, ESR2, PGR, CYP19A1
18raloxifene44 50 28 1112.3PGR, ESR2, ESR1, TGFB3, GNRH1, CYP19A1
194-hydroxytamoxifen449.2ESR2, PGR, ESR1, VIM, CYP19A1, TGFB3
20steroidal449.2CYP19A1, ESR2, GNRH1, OXTR, ESR1, PGR
21mifepristone44 28 61 1112.1CYP19A1, GNRH1, PGR, ESR2, ESR1, OXTR
22letrozole44 50 61 1112.1ESR1, CYP19A1, ESR2, PGR
23dihydrotestosterone44 28 24 1112.1CYP19A1, DES, PGR, ESR2, GNRH1, ESR1
24procollagen449.1PCNA, ACTC1, VIM, DES, ADM
25doxorubicin44 50 1111.1CYP19A1, DES, VIM, ESR2, PGR, ESR1
26formaldehyde44 2410.0PCNA, ACTC1, DES, GNRH1, CYP19A1, VIM
27b 723449.0PCNA, DES, ACTC1, S100A1, VIM
28hematoxylin448.9DES, S100A1, PCNA, VIM, ACTC1
295fluorouracil448.8ESR1, PCNA, CYP19A1, GNRH1, PGR, TGFB3
30gnrh448.6ESR1, ESR2, TGFB3, PGR, VIM, GNRH1
31ribonucleic acid448.6ACTC1, OXTR, MYOG, ESR2, PGR, TGFB3
32genistein44 28 61 2 24 1113.5ESR2, CYP19A1, PGR, ESR1, PCNA, VIM
33indomethacin44 28 61 1111.5PCNA, CCL11, OXTR, VIM, CYP19A1, PGR
34progestin448.4OXTR, DES, CYP19A1, GNRH1, TGFB3, PGR
35adenylate448.3PGR, DES, OXTR, ADM, MYOG, VIM
36creatinine448.3DES, GNRH1, PCNA, VIM, FH, MYOG
37tamoxifen44 50 28 1111.1PGR, ADM, GNRH1, OXTR, PCNA, VIM
38estradiol44 24 119.9CYP19A1, GNRH1, TGFB3, PGR, ESR2, ESR1
39actinomycin d447.9VIM, ADM, CCL11, HMGA2, ESR1, ESR2
40arginine447.8CYP19A1, GNRH1, OXTR, DES, VIM, ADM
41thymidine44 248.5PCNA, CCL11, OXTR, DES, TGFB3, CYR61
42dexamethasone44 50 28 1110.4TGFB3, ESR2, VIM, PGR, CYP19A1, PCNA
43paraffin447.0HMGA2, S100A1, PCNA, ACTC1, ADM, MYOG
44cysteine446.9PCNA, MYOG, VIM, ESR2, PGR, CYR61
45testosterone44 61 24 119.9TGFB3, GNRH1, CYP19A1, DES, ESR1, VIM
46steroid446.5ACTC1, CCL11, OXTR, ADM, MYOG, ESR1
47vegf446.2PCNA, ACTC1, CCL11, OXTR, ADM, MYOG
48retinoic acid44 247.0HMGA2, S100A1, PCNA, ACTC1, CCL11, ADM
49progesterone44 28 61 24 119.9ACTC1, OXTR, ADM, VIM, ESR1, ESR2
50estrogen445.4MYOG, ESR1, ESR2, PGR, TGFB3, GNRH1

GO Terms for genes affiliated with Leiomyoma

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Cellular components related to Leiomyoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein-DNA complexGO:0329939.4MYOG, HMGA2
2nucleoplasmGO:0056548.4HMGA2, PCNA, MYOG, ESR1, ESR2, PGR
3extracellular regionGO:0055768.1CCL11, ADM, ESR2, TGFB3, GNRH1, CYR61

Biological processes related to Leiomyoma according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1uterus developmentGO:06006510.2ESR1, ESR2
2vagina developmentGO:06006810.2ESR2, ESR1
3muscle filament slidingGO:03004910.1DES, VIM, ACTC1
4androgen metabolic processGO:00820910.0ADM, ESR1, CYP19A1
5intracellular estrogen receptor signaling pathwayGO:03052010.0ESR1, ESR2
6positive regulation of sequence-specific DNA binding transcription factor activityGO:05109110.0HMGA2, ESR1, ESR2
7cellular response to estradiol stimulusGO:0713929.9MYOG, ESR1
8ERK1 and ERK2 cascadeGO:0703719.8OXTR, CCL11
9digestive tract developmentGO:0485659.8OXTR, TGFB3
10positive regulation of cell cycle arrestGO:0711589.7HMGA2, MYOG
11positive regulation of cytosolic calcium ion concentrationGO:0072049.7ESR1, ADM, OXTR
12cell-cell signalingGO:0072679.6ADM, ESR2, PGR, GNRH1
13female pregnancyGO:0075659.5GNRH1, TGFB3, ADM, OXTR
14negative regulation of cell proliferationGO:0082859.3ADM, MYOG, TGFB3, GNRH1
15heart developmentGO:0075079.1ADM, OXTR, PCNA
16positive regulation of apoptotic processGO:0430659.1CYR61, TGFB3, ADM, HMGA2
17signal transductionGO:0071658.9GNRH1, PGR, ESR2, ESR1, ADM, CCL11
18negative regulation of apoptotic processGO:0430668.7HMGA2, ACTC1, GNRH1, CYR61
19positive regulation of transcription from RNA polymerase II promoterGO:0459448.6HMGA2, MYOG, ESR1, TGFB3, CYR61

Molecular functions related to Leiomyoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1estrogen response element bindingGO:03405610.0ESR1, ESR2
2estrogen receptor activityGO:0302849.9ESR1, ESR2
3core promoter sequence-specific DNA bindingGO:0010469.9ESR1, ESR2
4steroid bindingGO:0054969.9ESR1, ESR2, PGR
5steroid hormone receptor activityGO:0037079.8PGR, ESR2, ESR1
6enzyme bindingGO:0198999.4PGR, ESR2, ESR1, HMGA2
7identical protein bindingGO:0428028.5S100A1, DES, TGFB3, ESR1, VIM, PCNA
8protein bindingGO:0055156.6DES, TGFB3, PGR, ESR2, ESR1, VIM

Products for genes affiliated with Leiomyoma

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Sources for Leiomyoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet