MCID: LMY002
MIFTS: 68

Leiomyoma malady

Cancer diseases category

Summaries for Leiomyoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 A leiomyoma (plural leiomyomas or leiomyomata) (leio- + myo- + -oma, \"smooth-muscle tumor\") is a... more...

MalaCards: Leiomyoma, also known as leiomyomatous neoplasm nos, is related to leiomyosarcoma and esophagitis. An important gene associated with Leiomyoma is DES (desmin), and among its related pathways are Rho Family GTPases and Cytoskeletal Signaling. The drugs leuprolide and leuprolide acetate and the compounds retinoic acid and progesterone have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, uterus and lung, and related mouse phenotypes are homeostasis/metabolism and behavior/neurological.

Disease Ontology:8 A cell type benign neoplasm that is a benign tumor of smooth muscle cells.

Aliases & Classifications for Leiomyoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

leiomyoma 8 10 44
leiomyomatous neoplasm nos 8
leiomyomatous neoplasm 8
leiomyomatous tumor 8
leiomyoma nos 8
fibroid tumor 60


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Disease Ontology8 DOID:127
MeSH34 D007889
NCIt39 C3157

Related Diseases for Leiomyoma

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17GeneCards, 18GeneDecks
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Diseases related to Leiomyoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 365)
idRelated DiseaseScoreTop Affiliating Genes
1leiomyosarcoma31.0ACTC1, PGR, MYOG, DES, FH, S100A1
2esophagitis30.7CCL11
3leiomyomatosis30.7ESR1, PGR, FH, GNRH1
4sarcoma30.6ACTC1, HMGA2, MYOG, DES, S100A1, VIM
5uterine fibroid30.6ESR1, HMGA2, PGR, FH, GNRH1
6gastrointestinal stromal tumor30.5ACTC1, PCNA, DES, S100A1, VIM
7endometriosis30.5ESR2, ESR1, ACTC1, PGR, CYP17A1, CYP19A1
8smooth muscle tumor30.4ESR1, ACTC1, HMGA2, PGR, PCNA, DCAF5
9myoma30.3ESR1, HMGA2, PGR, CYP19A1, FH, GNRHR
10lymphangioleiomyomatosis30.3ESR1, PGR, DES
11endometrial stromal sarcoma30.2ESR2, ESR1, ACTC1, PGR, CYP19A1, DES
12breast cancer30.2ESR2, ESR1, GJA1, PGR, CYP19A1
13adenoma30.1ESR2, ACTC1, HMGA2, GJA1, CYP17A1, PCNA
14infertility30.1ESR2, ESR1, CYP19A1, GNRHR, GNRH1
15ovarian cyst30.1ESR2, CYP19A1, GNRH1
16gynecomastia30.0ESR1, PGR, CYP17A1, CYP19A1, GNRH1
17lipoma30.0HMGA2, DES, S100A1
18hepatitis30.0CCL11
19malignant mesenchymoma30.0MYOG
20neurilemmoma29.9ACTC1, DES, S100A1, VIM
21papillary carcinoma29.9ESR1, ACTC1, PGR, S100A1
22leukemia29.9ESR2, HMGA2, CCL11
23liposarcoma29.9HMGA2, DES, VIM
24paraganglioma29.9FH, S100A1
25bladder carcinoma29.9PCNA, FH
26adenocarcinoma29.7TGFB3, ADM, ESR2, ESR1, ACTC1, HMGA2
27melanoma29.6TGFB3, ACTC1, GJA1, PCNA, DES, S100A1
28squamous cell carcinoma29.6TGFB3, ADM, ACTC1, HMGA2, GJA1, PCNA
29pituitary adenoma29.6ADM, ESR2, HMGA2, PCNA, GNRHR, GNRH1
30osteosarcoma29.6TGFB3, ESR2, ESR1, HMGA2, GJA1
31choriocarcinoma29.6ADM, ESR2, CYP19A1, GNRHR, GNRH1
32benign mesothelioma29.6ACTC1, MYOG, DES, S100A1, VIM
33hemangiopericytoma29.6ACTC1, DES, S100A1, VIM
34papilloma29.6ACTC1, GJA1, PCNA
35fibrous histiocytoma29.6ACTC1, DES, VIM
36retinoblastoma29.6ESR1, PCNA, MYOG
37angiosarcoma29.6ACTC1, VIM
38pleomorphic adenoma29.6HMGA2
39prostatic hypertrophy29.6GNRH1
40hemangioma29.6ACTC1
41lung cancer29.6PCNA
42neurofibroma29.6ACTC1, S100A1, VIM
43amenorrhea29.6GNRH1
44asthma29.6TGFB3, ADM, CCL11
45gastric leiomyoma10.7
46bladder leiomyoma10.6
47bizarre leiomyoma10.5
48cellular leiomyoma10.5
49lung leiomyoma10.5
50leiomyoma cutis10.5

Graphical network of the top 20 diseases related to Leiomyoma:



Diseases related to leiomyoma

Clinical Features for Leiomyoma

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Drugs & Therapeutics for Leiomyoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Leiomyoma

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Anatomical Context for Leiomyoma

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32MalaCards
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MalaCards organs/tissues related to Leiomyoma:

32
Smooth muscle, Uterus, Lung, Breast, Prostate, Ovary, Endothelial, Colon, Small intestine, Liver, Trachea, Placenta, Testis, Kidney, Heart, Pituitary, Lymph node, B cells, Myeloid, Adrenal gland, Spleen, Thyroid, Skeletal muscle, Salivary gland, Cervix, Pancreas, T cells, Testes, Adipocyte, Brain, Spinal cord, Bone, B lymphoblasts

Animal Models for Leiomyoma or affiliated genes

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36MGI
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Publications for Leiomyoma

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50PubMed
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Articles related to Leiomyoma:

(show top 50)    (show all 1337)
idTitleAuthorsYear
1
Giant leiomyoma of the retzius space: a case report. (23585976)
2013
2
Identification of CUX1 as the recurrent chromosomal band 7q22 target gene in human uterine leiomyoma. (22965931)
2013
3
Vascular leiomyoma of the foot: Ultrasound and histologic correlation. (24269072)
2013
4
Measurement of phenolic environmental estrogens in human urine samples by HPLC-MS/MS and primary discussion the possible linkage with uterine leiomyoma. (24060595)
2013
5
Phosphohistone-H3 and Ki-67 immunostaining in cutaneous pilar leiomyoma and leiomyosarcoma (atypical intradermal smooth muscle neoplasm). (23550775)
2013
6
Uterine artery embolization in single symptomatic leiomyoma: do anatomical imaging criteria predict clinical presentation and long-term outcome? (23943627)
2013
7
Cotyledonoid dissecting leiomyoma of the uterus with intravascular luminal growth: a case study. (24255637)
2013
8
Paraurethral leiomyoma. (24136487)
2013
9
Esophageal leiomyoma: experience from a single institution. (22458777)
2013
10
Obstructive uropathy secondary to uterine leiomyoma in a chimpanzee (Pan troglodytes). (23561890)
2012
11
Multifocal osteolytic lesions within lumbar spine in a middle-aged Chinese woman: a benign metastasizing leiomyoma? (21857396)
2012
12
Lenticular meridional astigmatism secondary to iris mesectodermal leiomyoma. (22153095)
2012
13
Leiomyoma of the kidney parenchyma. (21790866)
2011
14
Pulmonary and retroperitoneal benign metastasizing leiomyoma. (22384439)
2011
15
Expression of mucin-1, galectin-1 and galectin-3 in human leiomyosarcoma in comparison to leiomyoma and myometrium. (21378323)
2011
16
Outcome of arterial embolization of uterine leiomyoma: case report. (21793290)
2011
17
Video-assisted lobectomy for endobronchial leiomyoma. (21123193)
2011
18
Severe life-threatening hemoperitoneum from posttraumatic avulsion of a pedunculated uterine leiomyoma. (20728826)
2010
19
Hypovolemic shock due to giant uterus leiomyoma detachment. (21265397)
2010
20
Characteristics indicating adenomyosis coexisting with leiomyomas: a case-control study. (20176591)
2010
21
Tumor necrosis factor in uterine leiomyomas at various stages of tumor growth]. (20695192)
2010
22
Changes of mRNAs encoding alternatively spliced variants of procollagen C-endopeptidase in leiomyomas uteri depending on the phase of menstrual cycle and in postmenopausal women]. (19323056)
2009
23
A huge renal capsular leiomyoma mimicking retroperitoneal sarcoma. (19861873)
2009
24
Recurrent benign metastasizing leiomyoma after hysterectomy and bilateral salpingo-oophorectomy. (18259767)
2008
25
Cutaneous malignant melanoma metastatic to a uterine leiomyoma: a case report. (18839825)
2008
26
Bladder leiomyoma with right hydronephrosis. (16733626)
2007
27
Adenovirus-mediated delivery of a dominant-negative estrogen receptor gene in uterine leiomyoma cells abrogates estrogen- and progesterone-regulated gene expression. (17635941)
2007
28
Progesterone and progesterone receptor modulator in uterine leiomyoma growth. (17505936)
2007
29
"Seedling" mesenchymal tumors (gastrointestinal stromal tumors and leiomyomas) are common incidental tumors of the esophagogastric junction. (18059218)
2007
30
p53, epidermal growth factor, and platelet-derived growth factor in uterine leiomyosarcoma and leiomyomas. (16681772)
2006
31
Expression of Ets-1 proto-oncoprotein in gastrointestinal stromal tumors, leiomyomas and schwannomas. (16586544)
2006
32
A new case of Carney triad: gastrointestinal stromal tumours and leiomyoma of the oesophagus do not show activating mutations of KIT and platelet-derived growth factor receptor alpha. (17021135)
2006
33
No evidence for epigenetic inactivation of fumarate hydratase in leiomyomas and leiomyosarcomas. (15949892)
2006
34
A huge 'prostate-mimicking' vaginal leiomyoma with simultaneous expression of oestrogen and progesterone receptors. (16953866)
2006
35
Estrogen-induced changes in IGF-I, Myb family and MAP kinase pathway genes in human uterine leiomyoma and normal uterine smooth muscle cell lines. (15879465)
2005
36
Familial multiple cutaneous and uterine leiomyomas associated with papillary renal cell cancer. (15663510)
2005
37
Progesterone receptor modulator CDB-2914 down-regulates proliferative cell nuclear antigen and Bcl-2 protein expression and up-regulates caspase-3 and poly(adenosine 5'-diphosphate-ribose) polymerase expression in cultured human uterine leiomyoma cells. (15572421)
2005
38
Non-surgical management of leiomyoma: impact on fertility. (15129053)
2004
39
Differential expression, regulation, and induction of Smads, transforming growth factor-beta signal transduction pathway in leiomyoma, and myometrial smooth muscle cells and alteration by gonadotropin-releasing hormone analog. (12629129)
2003
40
Clinical implications of coexpression of growth arrest-specific gene 6 and receptor tyrosine kinases Axl and Sky in human uterine leiomyoma. (14561812)
2003
41
A comparative analysis of structure and spatial distribution of decorin in human leiomyoma and normal myometrium. (12495820)
2003
42
Comparative analysis of cyclin D1 and oestrogen receptor (alpha and beta) levels in human leiomyoma and adjacent myometrium. (11675476)
2001
43
Expression of the hypoxically regulated angiogenic factor adrenomedullin correlates with uterine leiomyoma vascular density. (10914728)
2000
44
Effects of progesterone on uterine leiomyoma growth and apoptosis. (11108863)
2000
45
Maintenance of imprinting of the insulin-like growth factor II gene (IGF2) and the small nuclear ribonucleoprotein polypeptide N gene (SNRPN) in the human uterus and leiomyoma. (8821886)
1996
46
Leiomyoma primary cultures have elevated transcriptional response to estrogen compared with autologous myometrial cultures. (9420857)
1995
47
MR appearance of an orbital leiomyoma. (8456731)
1993
48
Implantation site on a cellular leiomyoma: a light microscopic and immunohistochemical study. (2807023)
1989
49
Use of LHRH analogue to obtain reversible castration in a patient with benign metastasizing leiomyoma. (3085706)
1986
50
Ultrastructure of gastric leiomyoma. (5782439)
1969

Genetic Variations for Leiomyoma

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Expression for genes affiliated with Leiomyoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Leiomyoma

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Pathways for genes affiliated with Leiomyoma

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51QIAGEN, 4Cell Signaling Technology, 29KEGG, 37NCBI BioSystems Database, 53Reactome, 49PharmGKB, 52R&D Systems
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Compounds for genes affiliated with Leiomyoma

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44Novoseek, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 2BitterDB
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Compounds related to Leiomyoma according to GeneCards/GeneDecks:

(show top 50)    (show all 197)
idCompoundScoreTop Affiliating Genes
1retinoic acid44 2413.6PGR, CYP17A1, CYP19A1, PCNA, MYOG, DES
2progesterone44 59 28 11 2416.5VIM, S100A1, GNRH1, TGFB3, ADM, ESR2
3testosterone44 59 11 2415.4DES, GNRHR, GNRH1, VIM, MYOG, PCNA
4paraffin4412.2TGFB3, ADM, ESR2, ESR1, ACTC1, HMGA2
5estradiol44 11 2414.1TGFB3, ESR2, ESR1, GJA1, PGR, CYP17A1
6vegf4412.1TGFB3, PGR, ADM, ESR2, ESR1, VIM
7tamoxifen44 49 28 1115.1GNRHR, GNRH1, VIM, PCNA, CYP19A1, PGR
8steroid4412.0TGFB3, ADM, ESR1, ACTC1, CYP17A1, CYP19A1
9progestin4412.0GJA1, ESR1, ESR2, TGFB3, CYP19A1, CYP17A1
10dihydrotestosterone44 28 11 2414.8CYP17A1, PGR, ESR1, CYP19A1, GNRHR, DES
11gnrh4411.8ESR1, ESR2, GNRHR, VIM, GNRH1, CYP17A1
12ribonucleic acid4411.8ESR2, GNRH1, GNRHR, MYOG, CYP17A1, PGR
13doxorubicin44 49 1113.8ESR2, ESR1, VIM, GNRHR, DES, CYP19A1
14actinomycin d4411.8VIM, ADM, ESR2, HMGA2, DES, GNRHR
15oxygen44 2412.8ACTC1, GJA1, CYP17A1, CYP19A1, MYOG, DES
16genistein44 28 59 2 11 2416.8PGR, GJA1, ESR1, ESR2, CYP19A1, PCNA
17adenylate4411.7DES, MYOG, PGR, ESR2, ADM, VIM
18cysteine4411.7GJA1, VIM, PGR, PCNA, DES, S100A1
19leuprolide acetate4411.6TGFB3, ESR2, ESR1, PGR, CYP19A1, GNRHR
20raloxifene44 28 49 1114.6ESR2, ESR1, CYP19A1, GNRHR, GNRH1, PGR
21dexamethasone44 49 28 1114.5PCNA, TGFB3, GNRH1, CCL11, GJA1, CYP17A1
22steroidal4411.5CYP17A1, CYP19A1, PGR, ESR1, ESR2, GNRH1
23thymidine44 2412.5ADM, CCL11, GNRHR, PCNA, TGFB3, DES
24diethylstilbestrol44 28 1113.5CYP17A1, GNRH1, ESR2, ESR1, PGR, CYP19A1
25arginine4411.5DES, CYP19A1, VIM, GNRH1, PCNA, GNRHR
264-hydroxytamoxifen4411.4ESR1, TGFB3, ESR2, PGR, CYP19A1, VIM
2712-o-tetradecanoylphorbol 13-acetate4411.4CYP17A1, DES, ADM, GJA1, GNRHR, VIM
28danazol44 11 2413.4GNRHR, PCNA, PGR, ESR1, CYP19A1
29estrone44 28 11 2414.4GNRH1, CYP17A1, ESR1, PGR, ESR2, CYP19A1
30estradiol benzoate4411.4PGR, CYP19A1, GNRH1, ESR1, ESR2
31exemestane49 44 59 1114.4ESR2, ESR1, PGR, CYP17A1, CYP19A1
32bisphenol a4411.4CYP17A1, PGR, ESR1, CYP19A1, ESR2
33clomiphene citrate4411.4ESR1, CYP19A1, GNRH1, PGR, ESR2
34toremifene44 1112.3CYP19A1, GNRH1, PGR, ESR1, ESR2
35fulvestrant44 49 28 1114.3ESR2, ESR1, PGR, CYP19A1, PCNA
36letrozole44 49 59 1114.3CYP19A1, CYP17A1, PGR, ESR1, ESR2
37b 7234411.3PCNA, S100A1, VIM, ACTC1, DES
383beta-hydroxysteroid4411.2CYP17A1, PGR, CYP19A1, GJA1, ESR2
3917beta-hydroxysteroid4411.2ESR1, CYP17A1, PGR, CYP19A1, ESR2
40nandrolone44 2412.2ESR2, ESR1, CYP19A1, PGR
41progestins4411.2CYP19A1, PGR, ESR1, ESR2, GNRH1
42goserelin44 28 1113.1GNRHR, GNRH1
43estrogen4411.0MYOG
44reticulin4411.0VIM, DES, PCNA, ACTC1
45cycloheximide4411.0GNRHR, GJA1
46creatinine4410.9ACTC1, GNRH1, FH
47buserelin44 28 1112.9CYP19A1, GNRH1, PGR, GNRHR
48acetylcholine44 49 28 11 2414.9ADM, GJA1, S100A1, MYOG
49formaldehyde44 2411.8DES, ACTC1, GNRH1, CYP19A1, VIM, PCNA
50mucicarmine4410.8VIM, S100A1, DES, ACTC1

GO Terms for genes affiliated with Leiomyoma

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16Gene Ontology
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Cellular components related to Leiomyoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fascia adherensGO:00591610.7GJA1, DES
2protein-DNA complexGO:03299310.4HMGA2, MYOG

Biological processes related to Leiomyoma according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1signal transductionGO:00716511.4CCL11, GNRH1, PGR, GJA1, ESR1, ESR2
2cell-cell signalingGO:00726711.2GNRH1, PGR, GJA1, ESR2, ADM
3negative regulation of cell proliferationGO:00828511.1GNRH1, MYOG, TGFB3, ADM, GJA1
4androgen metabolic processGO:00820911.0ADM, CYP19A1, ESR1
5muscle filament slidingGO:03004910.9VIM, ACTC1, DES
6negative regulation of gene expressionGO:01062910.8ESR1, GJA1, PGR
7epithelial cell maturationGO:00207010.7GJA1, PGR
8vagina developmentGO:06006810.7ESR2, ESR1
9uterus developmentGO:06006510.6ESR1, ESR2
10female pregnancyGO:00756510.5TGFB3, ADM, GNRH1

Molecular functions related to Leiomyoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:04280211.2VIM, TGFB3, PCNA, DES, ESR1, S100A1
2steroid bindingGO:00549610.9ESR2, ESR1, PGR
3steroid hormone receptor activityGO:00370710.7PGR, ESR1, ESR2
4estrogen response element bindingGO:03405610.7ESR2, ESR1
5core promoter sequence-specific DNA bindingGO:00104610.7ESR1, ESR2
6estrogen receptor activityGO:03028410.4ESR1, ESR2

Products for genes affiliated with Leiomyoma

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Sources for Leiomyoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet