MCID: LMY002
MIFTS: 68

Leiomyoma malady

Cancer diseases category

Summaries for Leiomyoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 A leiomyoma (plural leiomyomas or leiomyomata) (leio- + myo- + -oma, \"smooth-muscle tumor\") is a... more...

MalaCards: Leiomyoma, also known as leiomyomatous neoplasm nos, is related to leiomyosarcoma and esophagitis. An important gene associated with Leiomyoma is DES (desmin), and among its related pathways are Rho Family GTPases and Cytoskeletal Signaling. The drugs leuprolide and leuprolide acetate and the compounds retinoic acid and progesterone have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, uterus and lung, and related mouse phenotypes are homeostasis/metabolism and behavior/neurological.

Disease Ontology:8 A cell type benign neoplasm that is a benign tumor of smooth muscle cells.

Aliases & Classifications for Leiomyoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

leiomyoma 8 10 44
leiomyomatous neoplasm nos 8
leiomyomatous neoplasm 8
leiomyomatous tumor 8
leiomyoma nos 8
fibroid tumor 60


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Disease Ontology8 DOID:127
MeSH34 D007889
NCIt39 C3157

Related Diseases for Leiomyoma

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17GeneCards, 18GeneDecks
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Diseases related to Leiomyoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 365)
idRelated DiseaseScoreTop Affiliating Genes
1leiomyosarcoma31.0ACTC1, PGR, MYOG, DES, FH, S100A1
2esophagitis30.7CCL11
3leiomyomatosis30.7ESR1, PGR, FH, GNRH1
4sarcoma30.6ACTC1, HMGA2, MYOG, DES, S100A1, VIM
5uterine fibroid30.6ESR1, HMGA2, PGR, FH, GNRH1
6gastrointestinal stromal tumor30.5ACTC1, PCNA, DES, S100A1, VIM
7endometriosis30.5ESR2, ESR1, ACTC1, PGR, CYP17A1, CYP19A1
8smooth muscle tumor30.4ESR1, ACTC1, HMGA2, PGR, PCNA, DCAF5
9myoma30.3ESR1, HMGA2, PGR, CYP19A1, FH, GNRHR
10lymphangioleiomyomatosis30.3ESR1, PGR, DES
11endometrial stromal sarcoma30.2ESR2, ESR1, ACTC1, PGR, CYP19A1, DES
12breast cancer30.2ESR2, ESR1, GJA1, PGR, CYP19A1
13adenoma30.1ESR2, ACTC1, HMGA2, GJA1, CYP17A1, PCNA
14infertility30.1ESR2, ESR1, CYP19A1, GNRHR, GNRH1
15ovarian cyst30.1ESR2, CYP19A1, GNRH1
16gynecomastia30.0ESR1, PGR, CYP17A1, CYP19A1, GNRH1
17lipoma30.0HMGA2, DES, S100A1
18hepatitis30.0CCL11
19malignant mesenchymoma30.0MYOG
20neurilemmoma29.9ACTC1, DES, S100A1, VIM
21papillary carcinoma29.9ESR1, ACTC1, PGR, S100A1
22leukemia29.9ESR2, HMGA2, CCL11
23liposarcoma29.9HMGA2, DES, VIM
24paraganglioma29.9FH, S100A1
25bladder carcinoma29.9PCNA, FH
26adenocarcinoma29.7TGFB3, ADM, ESR2, ESR1, ACTC1, HMGA2
27melanoma29.6TGFB3, ACTC1, GJA1, PCNA, DES, S100A1
28squamous cell carcinoma29.6TGFB3, ADM, ACTC1, HMGA2, GJA1, PCNA
29pituitary adenoma29.6ADM, ESR2, HMGA2, PCNA, GNRHR, GNRH1
30osteosarcoma29.6TGFB3, ESR2, ESR1, HMGA2, GJA1
31choriocarcinoma29.6ADM, ESR2, CYP19A1, GNRHR, GNRH1
32benign mesothelioma29.6ACTC1, MYOG, DES, S100A1, VIM
33hemangiopericytoma29.6ACTC1, DES, S100A1, VIM
34papilloma29.6ACTC1, GJA1, PCNA
35fibrous histiocytoma29.6ACTC1, DES, VIM
36retinoblastoma29.6ESR1, PCNA, MYOG
37angiosarcoma29.6ACTC1, VIM
38pleomorphic adenoma29.6HMGA2
39prostatic hypertrophy29.6GNRH1
40hemangioma29.6ACTC1
41lung cancer29.6PCNA
42neurofibroma29.6ACTC1, S100A1, VIM
43amenorrhea29.6GNRH1
44asthma29.6TGFB3, ADM, CCL11
45gastric leiomyoma10.7
46bladder leiomyoma10.6
47bizarre leiomyoma10.5
48cellular leiomyoma10.5
49lung leiomyoma10.5
50leiomyoma cutis10.5

Graphical network of the top 20 diseases related to Leiomyoma:



Diseases related to leiomyoma

Clinical Features for Leiomyoma

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Drugs & Therapeutics for Leiomyoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Leiomyoma

Drug clinical trials:

Search ClinicalTrials for Leiomyoma

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Search CenterWatch for Leiomyoma

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Leiomyoma

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Anatomical Context for Leiomyoma

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32MalaCards
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MalaCards organs/tissues related to Leiomyoma:

32
Smooth muscle, Uterus, Lung, Breast, Prostate, Endothelial, Ovary, Colon, Small intestine, Liver, Placenta, Trachea, Kidney, Testis, Adrenal gland, Thyroid, Pituitary, B cells, Heart, Spleen, Lymph node, Myeloid, Skeletal muscle, T cells, B lymphoblasts, Cervix, Testes, Salivary gland, Pancreas, Adipocyte, Spinal cord, Brain, Bone

Animal Models for Leiomyoma or affiliated genes

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36MGI
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Publications for Leiomyoma

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50PubMed
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Articles related to Leiomyoma:

(show top 50)    (show all 1337)
idTitleAuthorsYear
1
Differential expression of G-protein-coupled estrogen receptor-30 in human myometrial and uterine leiomyoma smooth muscle. (23043685)
2013
2
Endometrium evaluation with high-field (3-Tesla) magnetic resonance imaging in patients submitted to uterine leiomyoma embolization. (23579745)
2013
3
Frequency of endometriosis and adenomyosis in patients with leiomyomas, gynecologic premalignant, and malignant neoplasias. (23724504)
2013
4
Measurement of phenolic environmental estrogens in women with uterine leiomyoma. (24255718)
2013
5
Delayed diagnosis of vaginal leiomyoma following misrepresentative core biopsy. (23635824)
2013
6
Extracellular matrix collagen alters cell proliferation and cell cycle progression of human uterine leiomyoma smooth muscle cells. (24040420)
2013
7
Acute abdomen caused by huge pedunculated uterine leiomyoma in torsion. (23350986)
2013
8
Intragastric endoscopic assisted single incision surgery for gastric leiomyoma of the esophagogastric junction. (24416603)
2013
9
Effect of the aromatase inhibitor anastrozole on uterine and leiomyoma Doppler blood flow in patients scheduled for hysterectomy: a pilot study. (22102490)
2012
10
Cystoscopic enucleation of bladder leiomyoma. (22346100)
2012
11
A uterine leiomyoma in which a leiomyosarcoma with osteoclast-like giant cells and a metastasis of a ductal breast carcinoma are present. (21216642)
2012
12
Diameter of dominant leiomyoma is a possible determinant to predict coexistent endometriosis. (22377227)
2012
13
An unusual case of an osteosarcoma arising in a leiomyoma of the uterus. (22634486)
2012
14
Evaluation of 14-3-3 protein family levels and associated receptor expression of estrogen and progesterone in human uterine leiomyomas. (22329840)
2012
15
Pulmonary artery extension of uterine leiomyoma. (22640175)
2012
16
Giant uterine leiomyoma. (22165069)
2011
17
Hypermethylated DAPK in serum DNA of women with uterine leiomyoma is a biomarker not restricted to cancer. (21159370)
2011
18
Leiomyoma of oral cavity: case report and literature review. (22238716)
2011
19
A case of endobronchial leiomyoma and carcinoma in situ treated with electrocautery using flexible bronchoscopy. (23168519)
2009
20
Endobronchial leiomyoma: an unusual non-defining neoplasm in a patient with AIDS. (19229392)
2009
21
Intramural bladder leiomyoma appearing as a pelvic tumor: a case report. (17270338)
2008
22
Memy I: a novel murine model for uterine leiomyoma using adenovirus-enhanced human fibroid explants in severe combined immune deficiency mice. (18468574)
2008
23
Prolactin receptors in uterine leiomyomas. (18998007)
2008
24
Expression of mRNA for chemokines and chemokine receptors in tissues of the myometrium and uterine leiomyoma. (19024011)
2008
25
Association of the CYP17 gene polymorphism with risk for uterine leiomyoma in Brazilian women. (18645709)
2008
26
Reduced expression of 14-3-3 gamma in uterine leiomyoma as identified by proteomics. (18054924)
2008
27
Estrogen receptor alpha (ERalpha) phospho-serine-118 is highly expressed in human uterine leiomyomas compared to matched myometrium. (18853184)
2008
28
The expression of estrogen receptor isoforms alpha, beta and insulin-like growth factor-I in uterine leiomyoma. (19012097)
2008
29
A comparative study of the effect of raloxifene and gosereline on uterine leiomyoma volume changes and estrogen receptor, progesterone receptor, bcl-2 and p53 expression immunohistochemically in premenopausal women. (16973256)
2007
30
Novel method to characterize primary cultures of leiomyoma and myometrium with the use of confirmatory biomarker gene arrays. (17222838)
2007
31
Fundal leiomyoma presenting as acute on chronic uterine inversion. (16368606)
2005
32
Leiomyoma of the orbit and periocular region: a clinicopathologic study of four cases. (15677948)
2005
33
Insulin-like growth factor 1 receptor mRNA expression and autophosphorylation in human myometrium and leiomyoma. (14963370)
2004
34
Immunohistochemical markers in differential diagnosis of endometrial stromal sarcoma and cellular leiomyoma. (14751141)
2004
35
Sex steroidal regulation of uterine leiomyoma growth and apoptosis. (15140868)
2004
36
Laparoscopic wedge resection of gastric leiomyoma. (14974670)
2004
37
Uterus didelphys with cervical agenesis associated with adenomyosis, a leiomyoma and ovarian endometriosis. A case report. (12497685)
2002
38
Interleukin 8 production and interleukin 8 receptor expression in human myometrium and leiomyoma. (11262453)
2001
39
MRI of round ligament leiomyoma associated with Mayer-Rokitansky-Kuster-Hauser syndrome. (10024414)
1999
40
Comparative messenger ribonucleic acid analysis of immediate early genes and sex steroid receptors in human leiomyoma and healthy myometrium. (9253340)
1997
41
Expression of thymidine phosphorylase in uterine sarcoma and uterine leiomyoma: association with microvessel density and Doppler blood flow analysis. (9263424)
1997
42
Combined laparoscopic and endoscopic approach to resection of gastric leiomyoma. (7612942)
1995
43
Mitogenic effect of basic fibroblast growth factor and estradiol on cultured human myometrial and leiomyoma cells. (7645636)
1995
44
Leiomyoma of the oral cavity: a light microscopic and immunohistochemical study with review of the literature from 1884 to 1992. (9135966)
1994
45
Raised serum CA125 level in leiomyoma and leiomyosarcoma of gastrointestinal origin. (8205452)
1994
46
Raised serum CA125 level in leiomyoma and leiomyosarcoma of gastrointestinal origin. (8298923)
1993
47
Benign metastasizing leiomyoma. (6703252)
1984
48
Benign mesothelioma simulating a uterine leiomyoma. (686114)
1978
49
Giant esophageal leiomyoma with secondary megaesophagus. (1257906)
1976
50
Leiomyoma of the esophagus: an unusual smooth muscle tumor. (13901326)
1961

Genetic Variations for Leiomyoma

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Expression for genes affiliated with Leiomyoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Leiomyoma

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Pathways for genes affiliated with Leiomyoma

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51QIAGEN, 4Cell Signaling Technology, 29KEGG, 37NCBI BioSystems Database, 53Reactome, 49PharmGKB, 52R&D Systems
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Compounds for genes affiliated with Leiomyoma

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44Novoseek, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 2BitterDB
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Compounds related to Leiomyoma according to GeneCards/GeneDecks:

(show top 50)    (show all 197)
idCompoundScoreTop Affiliating Genes
1retinoic acid44 2413.6PGR, CYP17A1, CYP19A1, PCNA, MYOG, DES
2progesterone44 59 28 11 2416.5VIM, S100A1, GNRH1, TGFB3, ADM, ESR2
3testosterone44 59 11 2415.4DES, GNRHR, GNRH1, VIM, MYOG, PCNA
4paraffin4412.2TGFB3, ADM, ESR2, ESR1, ACTC1, HMGA2
5estradiol44 11 2414.1TGFB3, ESR2, ESR1, GJA1, PGR, CYP17A1
6vegf4412.1TGFB3, PGR, ADM, ESR2, ESR1, VIM
7tamoxifen44 49 28 1115.1GNRHR, GNRH1, VIM, PCNA, CYP19A1, PGR
8steroid4412.0TGFB3, ADM, ESR1, ACTC1, CYP17A1, CYP19A1
9progestin4412.0GJA1, ESR1, ESR2, TGFB3, CYP19A1, CYP17A1
10dihydrotestosterone44 28 11 2414.8CYP17A1, PGR, ESR1, CYP19A1, GNRHR, DES
11gnrh4411.8ESR1, ESR2, GNRHR, VIM, GNRH1, CYP17A1
12ribonucleic acid4411.8ESR2, GNRH1, GNRHR, MYOG, CYP17A1, PGR
13doxorubicin44 49 1113.8ESR2, ESR1, VIM, GNRHR, DES, CYP19A1
14actinomycin d4411.8VIM, ADM, ESR2, HMGA2, DES, GNRHR
15oxygen44 2412.8ACTC1, GJA1, CYP17A1, CYP19A1, MYOG, DES
16genistein44 28 59 2 11 2416.8PGR, GJA1, ESR1, ESR2, CYP19A1, PCNA
17adenylate4411.7DES, MYOG, PGR, ESR2, ADM, VIM
18cysteine4411.7GJA1, VIM, PGR, PCNA, DES, S100A1
19leuprolide acetate4411.6TGFB3, ESR2, ESR1, PGR, CYP19A1, GNRHR
20raloxifene44 28 49 1114.6ESR2, ESR1, CYP19A1, GNRHR, GNRH1, PGR
21dexamethasone44 49 28 1114.5PCNA, TGFB3, GNRH1, CCL11, GJA1, CYP17A1
22steroidal4411.5CYP17A1, CYP19A1, PGR, ESR1, ESR2, GNRH1
23thymidine44 2412.5ADM, CCL11, GNRHR, PCNA, TGFB3, DES
24diethylstilbestrol44 28 1113.5CYP17A1, GNRH1, ESR2, ESR1, PGR, CYP19A1
25arginine4411.5DES, CYP19A1, VIM, GNRH1, PCNA, GNRHR
264-hydroxytamoxifen4411.4ESR1, TGFB3, ESR2, PGR, CYP19A1, VIM
2712-o-tetradecanoylphorbol 13-acetate4411.4CYP17A1, DES, ADM, GJA1, GNRHR, VIM
28danazol44 11 2413.4GNRHR, PCNA, PGR, ESR1, CYP19A1
29estrone44 28 11 2414.4GNRH1, CYP17A1, ESR1, PGR, ESR2, CYP19A1
30estradiol benzoate4411.4PGR, CYP19A1, GNRH1, ESR1, ESR2
31exemestane49 44 59 1114.4ESR2, ESR1, PGR, CYP17A1, CYP19A1
32bisphenol a4411.4CYP17A1, PGR, ESR1, CYP19A1, ESR2
33clomiphene citrate4411.4ESR1, CYP19A1, GNRH1, PGR, ESR2
34toremifene44 1112.3CYP19A1, GNRH1, PGR, ESR1, ESR2
35fulvestrant44 49 28 1114.3ESR2, ESR1, PGR, CYP19A1, PCNA
36letrozole44 49 59 1114.3CYP19A1, CYP17A1, PGR, ESR1, ESR2
37b 7234411.3PCNA, S100A1, VIM, ACTC1, DES
383beta-hydroxysteroid4411.2CYP17A1, PGR, CYP19A1, GJA1, ESR2
3917beta-hydroxysteroid4411.2ESR1, CYP17A1, PGR, CYP19A1, ESR2
40nandrolone44 2412.2ESR2, ESR1, CYP19A1, PGR
41progestins4411.2CYP19A1, PGR, ESR1, ESR2, GNRH1
42goserelin44 28 1113.1GNRHR, GNRH1
43estrogen4411.0MYOG
44reticulin4411.0VIM, DES, PCNA, ACTC1
45cycloheximide4411.0GNRHR, GJA1
46creatinine4410.9ACTC1, GNRH1, FH
47buserelin44 28 1112.9CYP19A1, GNRH1, PGR, GNRHR
48acetylcholine44 49 28 11 2414.9ADM, GJA1, S100A1, MYOG
49formaldehyde44 2411.8DES, ACTC1, GNRH1, CYP19A1, VIM, PCNA
50mucicarmine4410.8VIM, S100A1, DES, ACTC1

GO Terms for genes affiliated with Leiomyoma

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16Gene Ontology
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Cellular components related to Leiomyoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fascia adherensGO:00591610.7GJA1, DES
2protein-DNA complexGO:03299310.4HMGA2, MYOG

Biological processes related to Leiomyoma according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1signal transductionGO:00716511.4CCL11, GNRH1, PGR, GJA1, ESR1, ESR2
2cell-cell signalingGO:00726711.2GNRH1, PGR, GJA1, ESR2, ADM
3negative regulation of cell proliferationGO:00828511.1TGFB3, ADM, GJA1, MYOG, GNRH1
4androgen metabolic processGO:00820911.0ADM, ESR1, CYP19A1
5muscle filament slidingGO:03004910.9VIM, DES, ACTC1
6negative regulation of gene expressionGO:01062910.8PGR, GJA1, ESR1
7epithelial cell maturationGO:00207010.7GJA1, PGR
8vagina developmentGO:06006810.7ESR2, ESR1
9uterus developmentGO:06006510.6ESR2, ESR1
10female pregnancyGO:00756510.5TGFB3, ADM, GNRH1

Molecular functions related to Leiomyoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:04280211.2TGFB3, VIM, S100A1, DES, PCNA, ESR1
2steroid bindingGO:00549610.9ESR2, ESR1, PGR
3steroid hormone receptor activityGO:00370710.7ESR2, ESR1, PGR
4estrogen response element bindingGO:03405610.7ESR1, ESR2
5core promoter sequence-specific DNA bindingGO:00104610.7ESR2, ESR1
6estrogen receptor activityGO:03028410.4ESR2, ESR1

Products for genes affiliated with Leiomyoma

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Sources for Leiomyoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet