MCID: LMY002
MIFTS: 67

Leiomyoma malady

Cancer diseases category

Summaries for Leiomyoma

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9Disease Ontology, 66Wikipedia, 34MalaCards
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Wikipedia:66 A leiomyoma (plural leiomyomas or leiomyomata) (leio- + myo- + -oma, \"smooth-muscle tumor\") is a... more...

MalaCards: Leiomyoma, also known as leiomyomatous neoplasm nos, is related to leiomyomatosis and leiomyosarcoma. An important gene associated with Leiomyoma is DES (desmin), and among its related pathways are MNAR-PELP1 and Estrogen Receptor Interaction and Striated Muscle Contraction. The drugs leuprolide and leuprolide acetate and the compounds idoxifene and goserelin have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, uterus and lung, and related mouse phenotypes are limbs/digits/tail and adipose tissue.

Disease Ontology:9 A cell type benign neoplasm that is a benign tumor of smooth muscle cells.

Aliases & Classifications for Leiomyoma

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9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 36MeSH, 59SNOMED-CT, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

leiomyoma 9 11 46
leiomyomatous neoplasm nos 9
leiomyomatous neoplasm 9
leiomyomatous tumor 9
leiomyoma nos 9
fibroid tumor 63


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Disease Ontology9 DOID:127
MeSH36 D007889
NCIt41 C3157

Related Diseases for Leiomyoma

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18GeneCards, 19GeneDecks
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Diseases related to Leiomyoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 316)
idRelated DiseaseScoreTop Affiliating Genes
1leiomyomatosis30.9GNRH1, PGR, ESR1, FH
2leiomyosarcoma30.9S100A1, FH, ACTC1, CCL11, MYOG, VIM
3uterine fibroid30.7GNRH1, PGR, ESR1, FH, HMGA2
4sarcoma30.7DES, VIM, MYOG, ACTC1, S100A1, HMGA2
5gastrointestinal stromal tumor30.6DES, VIM, ACTC1, PCNA, S100A1
6uterine sarcoma30.6CYP19A1, DES, ESR1
7lymphangioleiomyomatosis30.5DES, PGR, ESR1
8myoma30.4HMGA2, FH, ESR1, PGR, GNRH1, CYP19A1
9breast cancer30.4CYP19A1, PGR, ESR2, ESR1
10endometriosis30.3OXTR, ESR1, ESR2, PGR, GNRH1, CYP19A1
11ovarian cyst30.3ESR2, GNRH1, CYP19A1
12endometrial stromal sarcoma30.3ACTC1, VIM, ESR1, ESR2, PGR, CYP19A1
13infertility30.2CYP19A1, GNRH1, ESR2, ESR1
14lipoma30.2DES, S100A1, HMGA2
15smooth muscle tumor30.2DES, HMGA2, S100A1, PCNA, ACTC1, CCL11
16gynecomastia30.2ESR1, PGR, GNRH1, CYP19A1
17adenoma30.1GNRH1, ESR2, ACTC1, PCNA, S100A1, HMGA2
18liposarcoma30.1HMGA2, VIM, DES
19neurilemmoma30.0S100A1, ACTC1, VIM, DES
20chondroma29.9HMGA2
21desmoid tumor29.9DES, ACTC1
22fibrous histiocytoma29.8DES, VIM, ACTC1
23neurofibroma29.8S100A1, ACTC1, VIM
24pituitary tumors29.8GNRH1, ESR2, ESR1
25hemangiopericytoma29.8S100A1, ACTC1, VIM, DES
26fibroma29.8DES, VIM, ACTC1, S100A1
27choriocarcinoma29.7ADM, ESR2, GNRH1, CYP19A1
28pituitary adenoma29.7HMGA2, PCNA, ADM, ESR2, GNRH1
29benign mesothelioma29.7DES, VIM, MYOG, ACTC1, S100A1
30fibromatosis29.7DES, TGFB3, PGR, VIM, ACTC1, S100A1
31osteosarcoma29.7TGFB3, ESR2, ESR1, OXTR, HMGA2
32wilms tumor29.6DES, CYR61, VIM, MYOG, ACTC1
33lung cancer29.5CYR61, ESR2, OXTR, PCNA, S100A1, HMGA2
34melanoma29.5DES, CYR61, TGFB3, VIM, CCL11, ACTC1
35adenocarcinoma29.4CYR61, TGFB3, PGR, ESR2, ESR1, VIM
36benign metastasizing leiomyoma10.8
37gastric leiomyoma10.8
38bladder leiomyoma10.6
39adenomyosis10.5
40esophagitis10.5
41leiomyoma cutis10.5
42bizarre leiomyoma10.5
43endobronchial leiomyoma10.5
44cellular leiomyoma10.4
45vaginitis10.4
46orbital leiomyoma10.4
47meigs syndrome10.4
48vulvar leiomyoma10.3
49pseudo-meigs syndrome10.3
50prostatitis10.3

Graphical network of the top 20 diseases related to Leiomyoma:



Diseases related to leiomyoma

Symptoms for Leiomyoma

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Drugs & Therapeutics for Leiomyoma

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Leiomyoma

Drug clinical trials:

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Search NIH Clinical Center for Leiomyoma

Search CenterWatch for Leiomyoma

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Leiomyoma

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Anatomical Context for Leiomyoma

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34MalaCards
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MalaCards organs/tissues related to Leiomyoma:

34
Smooth muscle, Uterus, Lung, Breast, Prostate, Ovary, Endothelial, Colon, Trachea, Small intestine, Liver, Placenta, Testis, Kidney, Heart, Spleen, B cells, Pituitary, Myeloid, Lymph node, Thyroid, Adrenal gland, Skeletal muscle, Adipocyte, Cervix, Brain, Salivary gland, Pancreas, Spinal cord, Bone, T cells, Testes, B lymphoblasts

Animal Models for Leiomyoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Leiomyoma:

38 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053719.2HMGA2, ESR1, ESR2, PGR, TGFB3
2MP:00053758.6CYP19A1, ESR2, ESR1, MYOG, PCNA, HMGA2
3MP:00053908.4CYP19A1, GNRH1, TGFB3, PGR, ESR2, ESR1
4MP:00053888.3TGFB3, ESR2, ESR1, VIM, MYOG, ADM
5MP:00053798.3CYP19A1, GNRH1, PGR, ESR2, ESR1, OXTR
6MP:00053708.1CYR61, CYP19A1, GNRH1, ESR2, ESR1, ADM
7MP:00107718.0CYP19A1, GNRH1, PGR, ESR2, ESR1, MYOG
8MP:00036317.9CYP19A1, GNRH1, TGFB3, ESR2, ESR1, VIM
9MP:00053977.8CYP19A1, GNRH1, PGR, ESR2, ESR1, VIM
10MP:00053807.8CYR61, TGFB3, PGR, ESR1, VIM, MYOG
11MP:00053877.8CYP19A1, GNRH1, PGR, ESR2, ESR1, VIM
12MP:00053897.7ESR2, PGR, GNRH1, CYP19A1, ESR1, VIM
13MP:00053847.5CYR61, CYP19A1, TGFB3, PGR, ESR2, ESR1
14MP:00053787.4CYP19A1, GNRH1, ESR2, ESR1, VIM, MYOG
15MP:00028737.2PGR, TGFB3, GNRH1, CYP19A1, ESR2, MYOG
16MP:00053697.2S100A1, DES, CYP19A1, PGR, ESR2, ESR1
17MP:00053857.0DES, CYR61, CYP19A1, TGFB3, PGR, ESR2
18MP:00053866.9DES, CYP19A1, TGFB3, PGR, ESR2, ESR1
19MP:00107686.5ESR2, PGR, TGFB3, CYR61, DES, ESR1
20MP:00053766.4PGR, TGFB3, GNRH1, CYP19A1, CYR61, DES

Publications for Leiomyoma

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53PubMed
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Articles related to Leiomyoma:

(show top 50)    (show all 1323)
idTitleAuthorsYear
1
Giant leiomyoma of the retzius space: a case report. (23585976)
2013
2
Angiomatous leiomyoma of the urachus: A rare entity masquerading as extraluminal gastrointestinal stromal tumor. (24049386)
2013
3
Human prolyl hydroxylase expression in uterine leiomyoma during the menstrual cycle. (23241241)
2012
4
Gonadotropin-releasing hormone (GnRH) agonist leuprolide acetate and GnRH antagonist cetrorelix acetate directly inhibit leiomyoma extracellular matrix production. (22901846)
2012
5
Effect of the aromatase inhibitor anastrozole on uterine and leiomyoma Doppler blood flow in patients scheduled for hysterectomy: a pilot study. (22102490)
2012
6
Leiomyoma of the Round Ligament of the Uterus: Case report and review of literature. (22912930)
2012
7
Obstructive uropathy secondary to uterine leiomyoma in a chimpanzee (Pan troglodytes). (23561890)
2012
8
Cystoscopic enucleation of bladder leiomyoma. (22346100)
2012
9
Hypoxia: the driving force of uterine myometrial stem cells differentiation into leiomyoma cells. (21903341)
2011
10
Massive Uterine Leiomyoma in a Patient with Friedreich's Ataxia: Is There a Possible Association? (21869894)
2011
11
MAPK14 cooperates with MAPK3/1 to regulate endothelin-1-mediated prostaglandin synthase 2 induction and survival in leiomyoma but not in normal myometrial cells. (21084714)
2011
12
Carcinosarcoma arising in a uterine leiomyoma: report of a unique neoplasm. (21979594)
2011
13
Resolution of eosinophilic gastroenteritis after resection of uterine leiomyomas. (22009412)
2011
14
Presentation of bladder leiomyoma concurrent with transitional cell carcinoma. (21333053)
2011
15
Leiomyoma of the urinary bladder: a series of nine cases and review of the literature. (20947147)
2010
16
Submucosal uterine leiomyomas have a global effect on molecular determinants of endometrial receptivity. (18555231)
2010
17
Progesterone is essential for maintenance and growth of uterine leiomyoma. (20375184)
2010
18
Progesterone receptor action in leiomyoma and endometrial cancer. (20374701)
2009
19
Estrogen receptor alpha-351 XbaI*G and -397 PvuII*C-related genotypes and alleles are associated with higher susceptibilities of endometriosis and leiomyoma. (17121748)
2007
20
A novel selective progesterone receptor modulator asoprisnil activates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated signaling pathway in cultured human uterine leiomyoma cells in the absence of comparable effects on myometrial cells. (17105846)
2007
21
Value of dynamic enhanced magnetic resonance imaging for distinguishing between ovarian fibroma and subserous uterine leiomyoma. (17414760)
2007
22
Color Doppler imaging and 3-dimensional sonographic findings of urinary bladder leiomyoma. (17460009)
2007
23
Progesterone receptor regulates Bcl-2 gene expression through direct binding to its promoter region in uterine leiomyoma cells. (17785366)
2007
24
Early growth response gene-1 plays a pivotal role in down-regulation of a cohort of genes in uterine leiomyoma. (17975260)
2007
25
Interleukin-6 -174G/C polymorphism in breast cancer and uterine leiomyoma patients: a population-based case control study. (18199986)
2007
26
Predictive value of magnetic resonance imaging in differentiating between leiomyoma and adenomyosis. (16882423)
2006
27
Ethnic distribution of estrogen receptor-alpha polymorphism is associated with a higher prevalence of uterine leiomyomas in black Americans. (16860797)
2006
28
Skeletal muscle-like and rhabdoid cells in uterine leiomyomas. (16175075)
2005
29
Combination of uterine adenomyosis with leiomyoma]. (16075610)
2005
30
Anterior orbital leiomyoma: possible pulley smooth muscle tissue tumor. (16286632)
2005
31
Bcl-2 receptor expression in patients with uterine smooth muscle tumors: an immunohistochemical analysis comparing leiomyoma, uterine smooth muscle tumor of uncertain malignant potential, and leiomyosarcoma. (15051039)
2004
32
An unusual gestational choriocarcinoma occurring primarily on the surface of a subserous leiomyoma. (14723763)
2004
33
Expression, menstrual cycle-dependent activation, and bimodal mitogenic effect of transforming growth factor-beta1 in human myometrium and leiomyoma. (12548199)
2003
34
A benefit-risk assessment of medical treatment for uterine leiomyomas. (12222988)
2002
35
Estrogen receptor-alpha and -beta expression in microvascular endothelial cells and smooth muscle cells of myometrium and leiomyoma. (12149410)
2002
36
Recurrent bladder leiomyoma with ovarian steroid hormone receptors. (11832749)
2002
37
Non-puerperal uterine inversion associated with an atypical leiomyoma. (11284635)
2001
38
Retroperitoneal leiomyomas: a clinicopathologic and immunohistochemical study of 56 cases with a comparison to retroperitoneal leiomyosarcomas. (11684951)
2001
39
Comparative analysis of cyclin D1 and oestrogen receptor (alpha and beta) levels in human leiomyoma and adjacent myometrium. (11675476)
2001
40
Bizarre leiomyoma of the epididymis. A case report. (11517827)
2000
41
Transforming growth factor-beta3 is expressed at high levels in leiomyoma where it stimulates fibronectin expression and cell proliferation. (10785229)
2000
42
Cellular leiomyoma mimicking endometrial stromal neoplasm in association with GnRH agonist goserelin. (10064405)
1999
43
Expression and imprinting of insulin-like growth factor II (IGF2) and H19 genes in uterine leiomyomas. (10479496)
1999
44
Genomic and functional map of the chromosome 14 t(12;14) breakpoint cluster region in uterine leiomyoma. (9740667)
1998
45
Somatic deletion of the 5' ends of both the COL4A5 and COL4A6 genes in a sporadic leiomyoma of the esophagus. (9502408)
1998
46
Laparoscopic intragastric surgery for gastric leiomyoma. (9079613)
1997
47
Calcified leiomyoma of deep soft tissue. Report of a case in childhood. (7952507)
1994
48
Endobronchial leiomyoma. (8500802)
1993
49
Urinary bladder leiomyoma: magnetic resonance imaging findings. (1290211)
1992
50
Giant esophageal leiomyoma with secondary megaesophagus. (1257906)
1976

Variations for Leiomyoma

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Expression for genes affiliated with Leiomyoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Leiomyoma

Search GEO for disease gene expression data for Leiomyoma.

Pathways for genes affiliated with Leiomyoma

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Sources:
51PathCards, 54QIAGEN, 39NCBI BioSystems Database, 56Reactome, 31KEGG, 52PharmGKB, 55R&D Systems
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Compounds for genes affiliated with Leiomyoma

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46Novoseek, 30IUPHAR, 12DrugBank, 25HMDB, 52PharmGKB, 62Tocris Bioscience, 3BitterDB
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Compounds related to Leiomyoma according to GeneCards/GeneDecks:

(show top 50)    (show all 185)
idCompoundScoreTop Affiliating Genes
1idoxifene469.9CYP19A1, ESR1, PGR
2goserelin46 30 1211.9CYP19A1, GNRH1, PGR, ESR1
3nandrolone46 2510.8ESR2, ESR1, CYP19A1, PGR
4exemestane46 52 62 1212.7PGR, CYP19A1, ESR2, ESR1
5anastrozole46 52 1211.7ESR2, PGR, CYP19A1, ESR1
6bisphenol a469.6PGR, CYP19A1, ESR2, ESR1
7estradiol benzoate469.6PGR, CYP19A1, ESR1, GNRH1, ESR2
8clomiphene citrate469.6ESR1, ESR2, PGR, GNRH1, CYP19A1
9toremifene46 1210.6GNRH1, PGR, ESR2, ESR1, CYP19A1
10reticulin469.5VIM, DES, PCNA, ACTC1
11tibolone469.5GNRH1, ESR1, CYP19A1, PGR
12diethylstilbestrol46 30 1211.5CYP19A1, GNRH1, ESR1, ESR2, PGR
13progestins469.5ESR1, PGR, GNRH1, ESR2, CYP19A1
14mucicarmine469.4VIM, ACTC1, S100A1, DES
15danazol46 25 1211.4CYP19A1, PCNA, PGR, GNRH1, ESR1
16leuprolide acetate469.3ESR1, ESR2, PGR, TGFB3, GNRH1, CYP19A1
17fulvestrant46 52 30 1212.3PCNA, ESR1, ESR2, PGR, CYP19A1
18raloxifene46 52 30 1212.3PGR, ESR2, ESR1, TGFB3, GNRH1, CYP19A1
194-hydroxytamoxifen469.2ESR2, PGR, ESR1, VIM, CYP19A1, TGFB3
20steroidal469.2CYP19A1, ESR2, GNRH1, OXTR, ESR1, PGR
21mifepristone46 30 62 1212.1CYP19A1, GNRH1, PGR, ESR2, ESR1, OXTR
22letrozole46 52 62 1212.1ESR1, CYP19A1, ESR2, PGR
23dihydrotestosterone46 30 25 1212.1CYP19A1, DES, PGR, ESR2, GNRH1, ESR1
24procollagen469.1PCNA, ACTC1, VIM, DES, ADM
25doxorubicin46 52 1211.1CYP19A1, DES, VIM, ESR2, PGR, ESR1
26formaldehyde46 2510.0PCNA, ACTC1, DES, GNRH1, CYP19A1, VIM
27b 723469.0PCNA, DES, ACTC1, S100A1, VIM
28hematoxylin468.9DES, S100A1, PCNA, VIM, ACTC1
295fluorouracil468.8ESR1, PCNA, CYP19A1, GNRH1, PGR, TGFB3
30gnrh468.6ESR1, ESR2, TGFB3, PGR, VIM, GNRH1
31ribonucleic acid468.6ACTC1, OXTR, MYOG, ESR2, PGR, TGFB3
32genistein46 30 62 3 25 1213.5ESR2, CYP19A1, PGR, ESR1, PCNA, VIM
33indomethacin46 30 62 1211.5PCNA, CCL11, OXTR, VIM, CYP19A1, PGR
34progestin468.4OXTR, DES, CYP19A1, GNRH1, TGFB3, PGR
35adenylate468.3PGR, DES, OXTR, ADM, MYOG, VIM
36creatinine468.3DES, GNRH1, PCNA, VIM, FH, MYOG
37tamoxifen46 52 30 1211.1PGR, ADM, GNRH1, OXTR, PCNA, VIM
38estradiol46 25 129.9CYP19A1, GNRH1, TGFB3, PGR, ESR2, ESR1
39actinomycin d467.9VIM, ADM, CCL11, HMGA2, ESR1, ESR2
40arginine467.8CYP19A1, GNRH1, OXTR, DES, VIM, ADM
41thymidine46 258.5PCNA, CCL11, OXTR, DES, TGFB3, CYR61
42dexamethasone46 52 30 1210.4TGFB3, ESR2, VIM, PGR, CYP19A1, PCNA
43paraffin467.0HMGA2, S100A1, PCNA, ACTC1, ADM, MYOG
44cysteine466.9PCNA, MYOG, VIM, ESR2, PGR, CYR61
45testosterone46 62 25 129.9TGFB3, GNRH1, CYP19A1, DES, ESR1, VIM
46steroid466.5ACTC1, CCL11, OXTR, ADM, MYOG, ESR1
47vegf466.2PCNA, ACTC1, CCL11, OXTR, ADM, MYOG
48retinoic acid46 257.0HMGA2, S100A1, PCNA, ACTC1, CCL11, ADM
49progesterone46 30 62 25 129.9ACTC1, OXTR, ADM, VIM, ESR1, ESR2
50estrogen465.4MYOG, ESR1, ESR2, PGR, TGFB3, GNRH1

GO Terms for genes affiliated with Leiomyoma

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17Gene Ontology
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Cellular components related to Leiomyoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein-DNA complexGO:0329939.4MYOG, HMGA2
2nucleoplasmGO:0056548.4HMGA2, PCNA, MYOG, ESR1, ESR2, PGR
3extracellular regionGO:0055768.1CCL11, ADM, ESR2, TGFB3, GNRH1, CYR61

Biological processes related to Leiomyoma according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1uterus developmentGO:06006510.2ESR1, ESR2
2vagina developmentGO:06006810.2ESR2, ESR1
3muscle filament slidingGO:03004910.1DES, VIM, ACTC1
4androgen metabolic processGO:00820910.0ADM, ESR1, CYP19A1
5intracellular estrogen receptor signaling pathwayGO:03052010.0ESR1, ESR2
6positive regulation of sequence-specific DNA binding transcription factor activityGO:05109110.0HMGA2, ESR1, ESR2
7cellular response to estradiol stimulusGO:0713929.9MYOG, ESR1
8ERK1 and ERK2 cascadeGO:0703719.8OXTR, CCL11
9digestive tract developmentGO:0485659.8OXTR, TGFB3
10positive regulation of cell cycle arrestGO:0711589.7HMGA2, MYOG
11positive regulation of cytosolic calcium ion concentrationGO:0072049.7ESR1, ADM, OXTR
12cell-cell signalingGO:0072679.6ADM, ESR2, PGR, GNRH1
13female pregnancyGO:0075659.5GNRH1, TGFB3, ADM, OXTR
14negative regulation of cell proliferationGO:0082859.3ADM, MYOG, TGFB3, GNRH1
15heart developmentGO:0075079.1ADM, OXTR, PCNA
16positive regulation of apoptotic processGO:0430659.1CYR61, TGFB3, ADM, HMGA2
17signal transductionGO:0071658.9GNRH1, PGR, ESR2, ESR1, ADM, CCL11
18negative regulation of apoptotic processGO:0430668.7HMGA2, ACTC1, GNRH1, CYR61
19positive regulation of transcription from RNA polymerase II promoterGO:0459448.6HMGA2, MYOG, ESR1, TGFB3, CYR61

Molecular functions related to Leiomyoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1estrogen response element bindingGO:03405610.0ESR1, ESR2
2estrogen receptor activityGO:0302849.9ESR1, ESR2
3core promoter sequence-specific DNA bindingGO:0010469.9ESR1, ESR2
4steroid bindingGO:0054969.9ESR1, ESR2, PGR
5steroid hormone receptor activityGO:0037079.8PGR, ESR2, ESR1
6enzyme bindingGO:0198999.4PGR, ESR2, ESR1, HMGA2
7identical protein bindingGO:0428028.5S100A1, DES, TGFB3, ESR1, VIM, PCNA
8protein bindingGO:0055156.6DES, TGFB3, PGR, ESR2, ESR1, VIM

Products for genes affiliated with Leiomyoma

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Sources for Leiomyoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet