MCID: LMY002
MIFTS: 61

Leiomyoma malady

Summaries for Leiomyoma

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Wikipedia:64 A leiomyoma (plural leiomyomas or leiomyomata) (leio- + myo- + -oma, \"smooth-muscle tumor\") is a... more...

MalaCards: Leiomyoma, also known as leiomyomatous neoplasm nos, is related to uterine fibroid and gastrointestinal stromal tumor. An important gene associated with Leiomyoma is DES (desmin), and among its related pathways are Rho Family GTPases and Cytoskeletal Signaling. The drugs leuprolide and leuprolide acetate and the compounds retinoic acid and progesterone have been mentioned in the context of this disorder. Related mouse phenotypes are homeostasis/metabolism and behavior/neurological.

Disease Ontology:8 A cell type benign neoplasm that is a benign tumor of smooth muscle cells.

Aliases & Classifications for Leiomyoma

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt
See all sources

Aliases & Descriptions:

leiomyoma 8 10 45
leiomyomatous neoplasm nos 8
leiomyomatous neoplasm 8
leiomyomatous tumor 8
leiomyoma nos 8
fibroid tumor 61


External Ids:

Disease Ontology8 DOID:127
MeSH35 D007889
NCIt40 C3157

Related Diseases for Leiomyoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Leiomyoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 346)
idRelated DiseaseScoreTop Affiliating Genes
1uterine fibroid30.6ESR1, HMGA2, PGR, FH, GNRH1
2gastrointestinal stromal tumor30.6ACTC1, PCNA, DES, S100A1, VIM
3uterine sarcoma30.5ESR1, CYP19A1, DES
4smooth muscle tumor30.4ESR1, ACTC1, HMGA2, PGR, PCNA, DCAF5
5myoma30.4PGR, DES
6lymphangioleiomyomatosis30.3ESR1, PGR, DES
7endometrial stromal sarcoma30.3ESR2, ESR1, ACTC1, PGR, CYP19A1, DES
8adenoma30.2ESR2, ACTC1, HMGA2, GJA1, CYP17A1, PCNA
9gynecomastia30.1ESR1, PGR, CYP17A1, CYP19A1, GNRH1
10teratoma30.0ACTC1
11infertility29.9ESR2, ESR1, CYP19A1, GNRHR, GNRH1
12papillary carcinoma29.9ESR1, ACTC1, PGR, S100A1
13paraganglioma29.9FH, S100A1
14bladder carcinoma29.9PCNA, FH
15adenocarcinoma29.7TGFB3, ADM, ESR2, ESR1, ACTC1, HMGA2
16squamous cell carcinoma29.7TGFB3, ADM, ACTC1, HMGA2, GJA1, PCNA
17fibromatosis29.7TGFB3, ACTC1, PGR, DES, S100A1, VIM
18benign mesothelioma29.7ACTC1, MYOG, DES, S100A1, VIM
19wilms tumor29.7ACTC1, MYOG, DES, VIM
20fibrous histiocytoma29.7ACTC1, DES, VIM
21breast cancer, invasive ductal29.7ESR1, PGR, PCNA
22desmoid tumor29.7ACTC1, DES
23angiosarcoma29.7ACTC1, VIM
24pleomorphic adenoma29.7HMGA2
25amenorrhea29.7GNRH1
26asthma29.7TGFB3, ADM, CCL11
27benign metastasizing leiomyoma10.8
28gastric leiomyoma10.7
29bladder leiomyoma10.7
30bizarre leiomyoma10.5
31adenomyosis10.5
32cellular leiomyoma10.5
33leiomyoma cutis10.5
34vagina leiomyoma10.5
35breast leiomyoma10.4
36endobronchial leiomyoma10.4
37orbital leiomyoma10.4
38esophagus leiomyoma10.3
39urethra leiomyoma10.3
40meigs syndrome10.3
41vulvar leiomyoma10.3
42pseudo-meigs syndrome10.3
43colon leiomyoma10.3
44prostate leiomyoma10.3
45trachea leiomyoma10.3
46small intestine leiomyoma10.3
47liver leiomyoma10.3
48leiomyoma, uterine, somatic10.3
49intravenous leiomyomatosis10.2
50deep leiomyoma10.2

Graphical network of the top 20 diseases related to Leiomyoma:



Diseases related to leiomyoma

Clinical Features for Leiomyoma

Drugs & Therapeutics for Leiomyoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Leiomyoma

Drug clinical trials:

Search ClinicalTrials for Leiomyoma

Search NIH Clinical Center for Leiomyoma

Search CenterWatch for Leiomyoma

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Leiomyoma

Anatomical Context for Leiomyoma

Animal Models for Leiomyoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Leiomyoma

Sources:
51PubMed
See all sources

Articles related to Leiomyoma:

(show top 50)    (show all 1942)
idTitleAuthorsYear
1
Uterine Intravenous Leiomyomatosis with Right Ventricular Extension. (24429697)
2014
2
Polymorphism of catechol-o-methyltransferase and uterine leiomyoma. (23238870)
2013
3
Disseminated Peritoneal Leiomyomatosis Clinically and Radiologically Mimicking Malignancy. (24196195)
2013
4
A rare pancreatic tumor in a 52-year-old Chinese woman. Pancreatic benign metastasizing leiomyoma. (23333466)
2013
5
Human prolyl hydroxylase expression in uterine leiomyoma during the menstrual cycle. (23241241)
2012
6
Leiomyoma recurrent at the cervical stump: report of two cases. (22196264)
2012
7
Humoral hypercalcemic crisis in a pregnant woman with uterine leiomyoma. (22416164)
2012
8
Successful extraction of cardiac-extending intravenous leiomyomatosis through gonadal vein. (22902061)
2012
9
Education and imaging: gastrointestinal: leiomyoma of the oesophagus. (23304729)
2012
10
Strong family history of uterine leiomyomatosis warrants fumarate hydratase mutation screening. (22473397)
2012
11
Intravenous leiomyomatosis of the uterus with extension to the right heart. (21943238)
2011
12
Abuse in childhood and risk of uterine leiomyoma: the role of emotional support in biologic resilience. (21068667)
2011
13
Enhanced transcription of estrogen receptor I+ and mitochondrial cytochrome b genes in uterine leiomyomas. (21506659)
2011
14
Plexiform leiomyoma of the esophagus: a complex radiographic, pathologic and endoscopic diagnosis. (21723760)
2011
15
Benign metastasizing leiomyoma with multiple lymph node metastasis: a case report. (21811430)
2011
16
Serial spread of benign metastasizing leiomyoma to the thoracic spine. (21658956)
2011
17
Endobronchial leiomyoma; report of a case successfully treated by bronchoscopic resection. (21526110)
2010
18
Progesterone and mifepristone regulate L-type amino acid transporter 2 and 4F2 heavy chain expression in uterine leiomyoma cells. (19808856)
2009
19
Acetaldehyde differentially affects the growth of uterine leiomyomata and myometrial cells in tissue cultures. (18304535)
2009
20
Disseminated peritoneal leiomyomatosis: an unusual complication of laparoscopic myomectomy. (18193441)
2008
21
Cystadenocarcinoma and leiomyoma in a peregrine falcon (Falco peregrinus brookei). (18587064)
2008
22
Mechanisms of disease: hereditary leiomyomatosis and renal cell cancer--a distinct form of hereditary kidney cancer. (17287871)
2007
23
Human myometrium and leiomyomas express gonadotropin-releasing hormone 2 and gonadotropin-releasing hormone 2 receptor. (17296196)
2007
24
Computed tomography of pancreatic implantation with malignant transformation of leiomyomatosis peritonealis disseminata in a man. (17415642)
2007
25
Benign metastasizing leiomyoma: clonality, telomere length and clinicopathologic analysis. (16357844)
2006
26
Evidence of increased microvessel density and activation of the hypoxia pathway in tumours from the hereditary leiomyomatosis and renal cell cancer syndrome. (15586379)
2005
27
Estrogen-induced changes in IGF-I, Myb family and MAP kinase pathway genes in human uterine leiomyoma and normal uterine smooth muscle cell lines. (15879465)
2005
28
Frequency, histological, and immunohistochemical properties of massive inflammatory lymphocytic infiltration of leiomyomas of the uterus: an entity causing diagnostic difficulties. (16175076)
2005
29
Expression of the mitogen-inducible gene-2 (mig-2) is elevated in human uterine leiomyomas but not in leiomyosarcomas. (14745725)
2004
30
Gonadotropin releasing hormone analogue therapy alters signal transduction pathways involving mitogen-activated protein and focal adhesion kinases in leiomyoma. (12517589)
2003
31
Benign myometrial conditions: leiomyomas and adenomyosis. (14578775)
2003
32
Recurrent bladder leiomyoma with ovarian steroid hormone receptors. (11832749)
2002
33
Urinary bladder leiomyoma during pregnancy: report of one case with immunohistochemical studies. (12554266)
2002
34
Cotyledonoid hydropic intravenous leiomyomatosis: a new variant leiomyoma. (11895490)
2002
35
A clinicopathological study of bizarre leiomyoma]. (12485480)
2002
36
Intravenous leiomyomatosis with cardiac extension in an elderly woman: report of a case]. (11517553)
2001
37
Genotype distribution of estrogen receptor-alpha gene polymorphisms in Italian women with surgical uterine leiomyomas. (11239543)
2001
38
Cutaneous leiomyomatosis with type 2 segmental involvement. (11436362)
2001
39
Progressive esophageal leiomyomatosis with respiratory compromise. (10789903)
2000
40
Topoisomerase I and II consensus sequences in a 17-kb deletion junction of the COL4A5 and COL4A6 genes and immunohistochemical analysis of esophageal leiomyomatosis associated with Alport syndrome. (9463311)
1998
41
Characteristics of bladder leiomyoma as noted on magnetic resonance imaging. (9836573)
1998
42
Hydropic degenerating leiomyoma presenting as pseudo-Meigs syndrome with elevated CA 125. (9764648)
1998
43
Diffuse leiomyomatosis associated with X-linked Alport syndrome: extracellular matrix study using immunohistochemistry and in situ hybridization. (9042160)
1997
44
Analysis of Ki-ras, p53, and MDM2 genes in uterine leiomyomas and leiomyosarcomas. (9159347)
1997
45
Estradiol-dependent uterine leiomyomas in transgenic mice. (8698870)
1996
46
Case report: intravenous leiomyomatosis, an unusual cause of intracardiac filling defect. (7867263)
1995
47
Presence of messenger ribonucleic acid for epidermal growth factor (EGF) and EGF receptor demonstrable in monolayer cell cultures of myometria and leiomyomata. (1936340)
1991
48
Intravenous leiomyomatosis of the uterus. A report of four cases. (13904785)
1961
49
GASTRIC leiomyoma; clinical conditions for diagnosis. (13638965)
1959
50
Calcified gastric leiomyoma. (14781350)
1950

Genetic Variations for Leiomyoma

Expression for genes affiliated with Leiomyoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Leiomyoma

Search GEO for disease gene expression data for Leiomyoma.

Pathways for genes affiliated with Leiomyoma

Sources:
52QIAGEN, 4Cell Signaling Technology, 30KEGG, 38NCBI BioSystems Database, 54Reactome, 50PharmGKB, 53R&D Systems
See all sources

Compounds for genes affiliated with Leiomyoma

Sources:
45Novoseek, 24HMDB, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Leiomyoma according to GeneCards/GeneDecks:

(show top 50)    (show all 197)
idCompoundScoreTop Affiliating Genes
1retinoic acid45 2413.6PGR, CYP17A1, CYP19A1, PCNA, MYOG, DES
2progesterone45 60 29 11 2416.5VIM, S100A1, GNRH1, TGFB3, ADM, ESR2
3testosterone45 60 11 2415.4DES, GNRHR, GNRH1, VIM, MYOG, PCNA
4paraffin4512.2TGFB3, ADM, ESR2, ESR1, ACTC1, HMGA2
5estradiol45 11 2414.1TGFB3, ESR2, ESR1, GJA1, PGR, CYP17A1
6vegf4512.1TGFB3, PGR, ADM, ESR2, ESR1, VIM
7tamoxifen45 50 29 1115.1GNRHR, GNRH1, VIM, PCNA, CYP19A1, PGR
8steroid4512.0TGFB3, ADM, ESR1, ACTC1, CYP17A1, CYP19A1
9progestin4512.0GJA1, ESR1, ESR2, TGFB3, CYP19A1, CYP17A1
10dihydrotestosterone45 29 11 2414.8CYP17A1, PGR, ESR1, CYP19A1, GNRHR, DES
11gnrh4511.8ESR1, ESR2, GNRHR, VIM, GNRH1, CYP17A1
12ribonucleic acid4511.8ESR2, GNRH1, GNRHR, MYOG, CYP17A1, PGR
13doxorubicin45 50 1113.8ESR2, ESR1, VIM, GNRHR, DES, CYP19A1
14actinomycin d4511.8VIM, ADM, ESR2, HMGA2, DES, GNRHR
15oxygen45 2412.8ACTC1, GJA1, CYP17A1, CYP19A1, MYOG, DES
16genistein45 29 60 2 11 2416.8PGR, GJA1, ESR1, ESR2, CYP19A1, PCNA
17adenylate4511.7DES, MYOG, PGR, ESR2, ADM, VIM
18cysteine4511.7GJA1, VIM, PGR, PCNA, DES, S100A1
19leuprolide acetate4511.6TGFB3, ESR2, ESR1, PGR, CYP19A1, GNRHR
20raloxifene45 29 50 1114.6ESR2, ESR1, CYP19A1, GNRHR, GNRH1, PGR
21dexamethasone45 50 29 1114.5PCNA, TGFB3, GNRH1, CCL11, GJA1, CYP17A1
22steroidal4511.5CYP17A1, CYP19A1, PGR, ESR1, ESR2, GNRH1
23thymidine45 2412.5ADM, CCL11, GNRHR, PCNA, TGFB3, DES
24diethylstilbestrol45 29 1113.5CYP17A1, GNRH1, ESR2, ESR1, PGR, CYP19A1
25arginine4511.5DES, CYP19A1, VIM, GNRH1, PCNA, GNRHR
264-hydroxytamoxifen4511.4ESR1, TGFB3, ESR2, PGR, CYP19A1, VIM
2712-o-tetradecanoylphorbol 13-acetate4511.4CYP17A1, DES, ADM, GJA1, GNRHR, VIM
28danazol45 11 2413.4GNRHR, PCNA, PGR, ESR1, CYP19A1
29estrone45 29 11 2414.4GNRH1, CYP17A1, ESR1, PGR, ESR2, CYP19A1
30estradiol benzoate4511.4PGR, CYP19A1, GNRH1, ESR1, ESR2
31exemestane50 45 60 1114.4ESR2, ESR1, PGR, CYP17A1, CYP19A1
32bisphenol a4511.4CYP17A1, PGR, ESR1, CYP19A1, ESR2
33clomiphene citrate4511.4ESR1, CYP19A1, GNRH1, PGR, ESR2
34toremifene45 1112.3CYP19A1, GNRH1, PGR, ESR1, ESR2
35fulvestrant45 50 29 1114.3ESR2, ESR1, PGR, CYP19A1, PCNA
36letrozole45 50 60 1114.3CYP19A1, CYP17A1, PGR, ESR1, ESR2
37b 7234511.3PCNA, S100A1, VIM, ACTC1, DES
383beta-hydroxysteroid4511.2CYP17A1, PGR, CYP19A1, GJA1, ESR2
3917beta-hydroxysteroid4511.2ESR1, CYP17A1, PGR, CYP19A1, ESR2
40nandrolone45 2412.2ESR2, ESR1, CYP19A1, PGR
41progestins4511.2CYP19A1, PGR, ESR1, ESR2, GNRH1
42goserelin45 29 1113.1GNRHR, GNRH1
43estrogen4511.0MYOG
44reticulin4511.0VIM, DES, PCNA, ACTC1
45cycloheximide4511.0GNRHR, GJA1
46creatinine4510.9ACTC1, GNRH1, FH
47buserelin45 29 1112.9CYP19A1, GNRH1, PGR, GNRHR
48acetylcholine45 50 29 11 2414.9ADM, GJA1, S100A1, MYOG
49formaldehyde45 2411.8DES, ACTC1, GNRH1, CYP19A1, VIM, PCNA
50mucicarmine4510.8VIM, S100A1, DES, ACTC1

GO Terms for genes affiliated with Leiomyoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Leiomyoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fascia adherensGO:00591610.7GJA1, DES
2protein-DNA complexGO:03299310.4HMGA2, MYOG

Biological processes related to Leiomyoma according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1signal transductionGO:00716511.4CCL11, GNRH1, PGR, GJA1, ESR1, ESR2
2cell-cell signalingGO:00726711.2GNRH1, PGR, GJA1, ESR2, ADM
3negative regulation of cell proliferationGO:00828511.1TGFB3, ADM, GJA1, MYOG, GNRH1
4androgen metabolic processGO:00820911.0ADM, ESR1, CYP19A1
5muscle filament slidingGO:03004910.9VIM, DES, ACTC1
6negative regulation of gene expressionGO:01062910.8PGR, GJA1, ESR1
7epithelial cell maturationGO:00207010.7GJA1, PGR
8vagina developmentGO:06006810.7ESR2, ESR1
9uterus developmentGO:06006510.6ESR2, ESR1
10female pregnancyGO:00756510.5TGFB3, ADM, GNRH1

Molecular functions related to Leiomyoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:04280211.2TGFB3, VIM, S100A1, DES, PCNA, ESR1
2steroid bindingGO:00549610.9ESR2, ESR1, PGR
3steroid hormone receptor activityGO:00370710.7ESR2, ESR1, PGR
4estrogen response element bindingGO:03405610.7ESR1, ESR2
5core promoter sequence-specific DNA bindingGO:00104610.7ESR2, ESR1
6estrogen receptor activityGO:03028410.4ESR2, ESR1

Products for genes affiliated with Leiomyoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Leiomyoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet