Aliases & Classifications for Leiomyoma

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 55SNOMED-CT, 33MeSH, 38NCIt, 25ICD10
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Leiomyoma, Aliases & Descriptions:

Name: Leiomyoma 9 11 43
Leiomyomatous Neoplasm 9
Leiomyomatous Tumor 9
 
Uterine Fibroids 60
Fibroid Tumor 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology9 DOID:127
MeSH33 D007889
NCIt38 C3157
ICD1025 D25.9

Summaries for Leiomyoma

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Wikipedia:63 A leiomyoma (plural leiomyomas or leiomyomata) (leio- + myo- + -oma, \"smooth-muscle tumor\") is a... more...

MalaCards based summary: Leiomyoma, also known as leiomyomatous neoplasm, is related to leiomyomatosis and renal cell carcinoma. An important gene associated with Leiomyoma is DES (desmin), and among its related pathways are MNAR-PELP1 and Estrogen Receptor Interaction and Striated Muscle Contraction. The drugs leuprolide and leuprolide acetate and the compounds idoxifene and goserelin have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, uterus and lung, and related mouse phenotypes are limbs/digits/tail and adipose tissue.

Disease Ontology:9 A cell type benign neoplasm that is a benign tumor of smooth muscle cells.

Related Diseases for Leiomyoma

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Diseases related to Leiomyoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 312)
idRelated DiseaseScoreTop Affiliating Genes
1leiomyomatosis31.2GNRH1, PGR, ESR1, FH
2renal cell carcinoma31.2FH
3uterine sarcoma31.0CYP19A1, DES, ESR1
4lymphangioleiomyomatosis31.0DES, PGR, ESR1
5myoma30.9DES, MYOG
6uterine fibroid30.8GNRH1, PGR, ESR1, FH, HMGA2
7gastrointestinal stromal tumor30.8DES, VIM, ACTC1, PCNA, S100A1
8lipoma30.6DES, S100A1, HMGA2
9sarcoma30.5DES, VIM, MYOG, ACTC1, S100A1, HMGA2
10ovarian cyst30.5ESR2, GNRH1, CYP19A1
11breast cancer30.5CYP19A1, PGR, ESR2, ESR1
12gynecomastia30.5ESR1, PGR, GNRH1, CYP19A1
13liposarcoma30.5HMGA2, VIM, DES
14chondroma30.4HMGA2
15leiomyosarcoma30.4S100A1, FH, ACTC1, CCL11, MYOG, VIM
16endometrial cancer30.4ESR1, ESR2, PGR
17infertility30.3CYP19A1, GNRH1, ESR2, ESR1
18malignant mixed mullerian tumor30.3VIM, ESR1, PGR
19fibrous histiocytoma30.3DES, VIM, ACTC1
20neurilemmoma30.2S100A1, ACTC1, VIM, DES
21neurofibroma30.1S100A1, ACTC1, VIM
22endometrial stromal sarcoma30.1ACTC1, VIM, ESR1, ESR2, PGR, CYP19A1
23pituitary tumors30.0GNRH1, ESR2, ESR1
24hemangiopericytoma30.0S100A1, ACTC1, VIM, DES
25fibroma30.0DES, VIM, ACTC1, S100A1
26adenoma30.0GNRH1, ESR2, ACTC1, PCNA, S100A1, HMGA2
27choriocarcinoma29.8ADM, ESR2, GNRH1, CYP19A1
28pituitary adenoma29.7HMGA2, PCNA, ADM, ESR2, GNRH1
29mesothelioma29.7DES, VIM, MYOG, ACTC1, S100A1
30fibromatosis29.7DES, TGFB3, PGR, VIM, ACTC1, S100A1
31smooth muscle tumor29.6DES, HMGA2, S100A1, PCNA, ACTC1, CCL11
32wilms tumor29.4DES, CYR61, VIM, MYOG, ACTC1
33endometriosis29.3OXTR, ESR1, ESR2, PGR, GNRH1, CYP19A1
34lung cancer29.1PCNA, OXTR, ESR2, CYR61
35melanoma28.8DES, CYR61, TGFB3, VIM, CCL11, ACTC1
36adenocarcinoma28.5CYR61, TGFB3, PGR, ESR2, ESR1, VIM
37benign metastasizing leiomyoma10.8
38gastric leiomyoma10.8
39bladder leiomyoma10.6
40infantile myofibromatosis10.6DES
41adenomyosis10.6
42esophagitis10.6
43bizarre leiomyoma10.6
44leiomyoma cutis10.5
45syringoma10.5S100A1
46cerebral meningioma10.5PGR
47cellular leiomyoma10.5
48fasciitis10.5ACTC1
49endobronchial leiomyoma10.5
50progesterone resistance10.5PGR, ESR1

Graphical network of the top 20 diseases related to Leiomyoma:



Diseases related to leiomyoma

Symptoms for Leiomyoma

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Drugs & Therapeutics for Leiomyoma

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Drug clinical trials:

Search ClinicalTrials for Leiomyoma

Search NIH Clinical Center for Leiomyoma

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Leiomyoma

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Anatomical Context for Leiomyoma

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MalaCards organs/tissues related to Leiomyoma:

31
Smooth muscle, Uterus, Lung, Breast, Prostate, Ovary, Endothelial, Colon, Small intestine, Liver, Placenta, Trachea, Kidney, Testis, Bone, Lymph node, Spleen, Heart, Thyroid, Adrenal gland, Cervix, Myeloid, B cells, Pituitary, Skeletal muscle, Brain, Spinal cord, Adipocyte, Pancreas, Salivary gland, Testes, T cells, B lymphoblasts, Appendix

Animal Models for Leiomyoma or affiliated genes

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MGI Mouse Phenotypes related to Leiomyoma:

35 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053719.2HMGA2, ESR1, ESR2, PGR, TGFB3
2MP:00053758.6CYP19A1, ESR2, ESR1, MYOG, PCNA, HMGA2
3MP:00053908.4CYP19A1, GNRH1, TGFB3, PGR, ESR2, ESR1
4MP:00053888.3TGFB3, ESR2, ESR1, VIM, MYOG, ADM
5MP:00053798.3CYP19A1, GNRH1, PGR, ESR2, ESR1, OXTR
6MP:00053708.1CYR61, CYP19A1, GNRH1, ESR2, ESR1, ADM
7MP:00107718.0CYP19A1, GNRH1, PGR, ESR2, ESR1, MYOG
8MP:00036317.9CYP19A1, GNRH1, TGFB3, ESR2, ESR1, VIM
9MP:00053977.8CYP19A1, GNRH1, PGR, ESR2, ESR1, VIM
10MP:00053807.8CYR61, TGFB3, PGR, ESR1, VIM, MYOG
11MP:00053877.8CYP19A1, GNRH1, PGR, ESR2, ESR1, VIM
12MP:00053897.7ESR2, PGR, GNRH1, CYP19A1, ESR1, VIM
13MP:00053847.5CYR61, CYP19A1, TGFB3, PGR, ESR2, ESR1
14MP:00053787.4CYP19A1, GNRH1, ESR2, ESR1, VIM, MYOG
15MP:00028737.2PGR, TGFB3, GNRH1, CYP19A1, ESR2, MYOG
16MP:00053697.2S100A1, DES, CYP19A1, PGR, ESR2, ESR1
17MP:00053857.0DES, CYR61, CYP19A1, TGFB3, PGR, ESR2
18MP:00053866.9DES, CYP19A1, TGFB3, PGR, ESR2, ESR1
19MP:00107686.5ESR2, PGR, TGFB3, CYR61, DES, ESR1
20MP:00053766.4PGR, TGFB3, GNRH1, CYP19A1, CYR61, DES

Publications for Leiomyoma

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Articles related to Leiomyoma:

(show top 50)    (show all 1402)
idTitleAuthorsYear
1
Simvastatin Potently Induces Calcium-Dependent Apoptosis of Human Leiomyoma Cells. (25359773)
2014
2
Leiomyomas beyond the uterus; benign metastasizing leiomyomatosis with paraaortic metastasizing endometriosis and intravenous leiomyomatosis: a case series and review of the literature. (25047270)
2014
3
Epigenetic alterations in a gastric leiomyoma. (25544907)
2014
4
Giant leiomyoma of the retzius space: a case report. (23585976)
2013
5
Angiomatous leiomyoma of the urachus: A rare entity masquerading as extraluminal gastrointestinal stromal tumor. (24049386)
2013
6
Human prolyl hydroxylase expression in uterine leiomyoma during the menstrual cycle. (23241241)
2012
7
Gonadotropin-releasing hormone (GnRH) agonist leuprolide acetate and GnRH antagonist cetrorelix acetate directly inhibit leiomyoma extracellular matrix production. (22901846)
2012
8
Effect of the aromatase inhibitor anastrozole on uterine and leiomyoma Doppler blood flow in patients scheduled for hysterectomy: a pilot study. (22102490)
2012
9
Leiomyoma of the Round Ligament of the Uterus: Case report and review of literature. (22912930)
2012
10
Obstructive uropathy secondary to uterine leiomyoma in a chimpanzee (Pan troglodytes). (23561890)
2012
11
Cystoscopic enucleation of bladder leiomyoma. (22346100)
2012
12
Hypoxia: the driving force of uterine myometrial stem cells differentiation into leiomyoma cells. (21903341)
2011
13
Massive Uterine Leiomyoma in a Patient with Friedreich's Ataxia: Is There a Possible Association? (21869894)
2011
14
MAPK14 cooperates with MAPK3/1 to regulate endothelin-1-mediated prostaglandin synthase 2 induction and survival in leiomyoma but not in normal myometrial cells. (21084714)
2011
15
Carcinosarcoma arising in a uterine leiomyoma: report of a unique neoplasm. (21979594)
2011
16
Resolution of eosinophilic gastroenteritis after resection of uterine leiomyomas. (22009412)
2011
17
Leiomyoma of the urinary bladder: a series of nine cases and review of the literature. (20947147)
2010
18
Submucosal uterine leiomyomas have a global effect on molecular determinants of endometrial receptivity. (18555231)
2010
19
Progesterone is essential for maintenance and growth of uterine leiomyoma. (20375184)
2010
20
Progesterone receptor action in leiomyoma and endometrial cancer. (20374701)
2009
21
Estrogen receptor alpha-351 XbaI*G and -397 PvuII*C-related genotypes and alleles are associated with higher susceptibilities of endometriosis and leiomyoma. (17121748)
2007
22
A novel selective progesterone receptor modulator asoprisnil activates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated signaling pathway in cultured human uterine leiomyoma cells in the absence of comparable effects on myometrial cells. (17105846)
2007
23
Value of dynamic enhanced magnetic resonance imaging for distinguishing between ovarian fibroma and subserous uterine leiomyoma. (17414760)
2007
24
Color Doppler imaging and 3-dimensional sonographic findings of urinary bladder leiomyoma. (17460009)
2007
25
Progesterone receptor regulates Bcl-2 gene expression through direct binding to its promoter region in uterine leiomyoma cells. (17785366)
2007
26
Early growth response gene-1 plays a pivotal role in down-regulation of a cohort of genes in uterine leiomyoma. (17975260)
2007
27
Interleukin-6 -174G/C polymorphism in breast cancer and uterine leiomyoma patients: a population-based case control study. (18199986)
2007
28
Predictive value of magnetic resonance imaging in differentiating between leiomyoma and adenomyosis. (16882423)
2006
29
Ethnic distribution of estrogen receptor-alpha polymorphism is associated with a higher prevalence of uterine leiomyomas in black Americans. (16860797)
2006
30
Skeletal muscle-like and rhabdoid cells in uterine leiomyomas. (16175075)
2005
31
Combination of uterine adenomyosis with leiomyoma]. (16075610)
2005
32
Anterior orbital leiomyoma: possible pulley smooth muscle tissue tumor. (16286632)
2005
33
Bcl-2 receptor expression in patients with uterine smooth muscle tumors: an immunohistochemical analysis comparing leiomyoma, uterine smooth muscle tumor of uncertain malignant potential, and leiomyosarcoma. (15051039)
2004
34
An unusual gestational choriocarcinoma occurring primarily on the surface of a subserous leiomyoma. (14723763)
2004
35
Expression, menstrual cycle-dependent activation, and bimodal mitogenic effect of transforming growth factor-beta1 in human myometrium and leiomyoma. (12548199)
2003
36
A benefit-risk assessment of medical treatment for uterine leiomyomas. (12222988)
2002
37
Estrogen receptor-alpha and -beta expression in microvascular endothelial cells and smooth muscle cells of myometrium and leiomyoma. (12149410)
2002
38
Recurrent bladder leiomyoma with ovarian steroid hormone receptors. (11832749)
2002
39
Non-puerperal uterine inversion associated with an atypical leiomyoma. (11284635)
2001
40
Retroperitoneal leiomyomas: a clinicopathologic and immunohistochemical study of 56 cases with a comparison to retroperitoneal leiomyosarcomas. (11684951)
2001
41
Comparative analysis of cyclin D1 and oestrogen receptor (alpha and beta) levels in human leiomyoma and adjacent myometrium. (11675476)
2001
42
Bizarre leiomyoma of the epididymis. A case report. (11517827)
2000
43
Cellular leiomyoma mimicking endometrial stromal neoplasm in association with GnRH agonist goserelin. (10064405)
1999
44
Expression and imprinting of insulin-like growth factor II (IGF2) and H19 genes in uterine leiomyomas. (10479496)
1999
45
Genomic and functional map of the chromosome 14 t(12;14) breakpoint cluster region in uterine leiomyoma. (9740667)
1998
46
Laparoscopic intragastric surgery for gastric leiomyoma. (9079613)
1997
47
Calcified leiomyoma of deep soft tissue. Report of a case in childhood. (7952507)
1994
48
Endobronchial leiomyoma. (8500802)
1993
49
Urinary bladder leiomyoma: magnetic resonance imaging findings. (1290211)
1992
50
Giant esophageal leiomyoma with secondary megaesophagus. (1257906)
1976

Variations for Leiomyoma

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Expression for genes affiliated with Leiomyoma

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Search GEO for disease gene expression data for Leiomyoma.

Pathways for genes affiliated with Leiomyoma

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Compounds for genes affiliated with Leiomyoma

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Compounds related to Leiomyoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 185)
idCompoundScoreTop Affiliating Genes
1idoxifene439.9CYP19A1, ESR1, PGR
2goserelin43 28 1211.9CYP19A1, GNRH1, PGR, ESR1
3nandrolone43 2410.8ESR2, ESR1, CYP19A1, PGR
4exemestane43 49 59 1212.7PGR, CYP19A1, ESR2, ESR1
5anastrozole43 49 1211.7ESR2, PGR, CYP19A1, ESR1
6bisphenol a439.6PGR, CYP19A1, ESR2, ESR1
7estradiol benzoate439.6PGR, CYP19A1, ESR1, GNRH1, ESR2
8clomiphene citrate439.6ESR1, ESR2, PGR, GNRH1, CYP19A1
9toremifene43 1210.6GNRH1, PGR, ESR2, ESR1, CYP19A1
10reticulin439.5VIM, DES, PCNA, ACTC1
11tibolone439.5GNRH1, ESR1, CYP19A1, PGR
12diethylstilbestrol43 28 1211.5CYP19A1, GNRH1, ESR1, ESR2, PGR
13progestins439.5ESR1, PGR, GNRH1, ESR2, CYP19A1
14mucicarmine439.4VIM, ACTC1, S100A1, DES
15danazol43 24 1211.4CYP19A1, PCNA, PGR, GNRH1, ESR1
16leuprolide acetate439.3ESR1, ESR2, PGR, TGFB3, GNRH1, CYP19A1
17fulvestrant43 49 28 1212.3PCNA, ESR1, ESR2, PGR, CYP19A1
18raloxifene43 49 28 1212.3PGR, ESR2, ESR1, TGFB3, GNRH1, CYP19A1
194-hydroxytamoxifen439.2ESR2, PGR, ESR1, VIM, CYP19A1, TGFB3
20steroidal439.2CYP19A1, ESR2, GNRH1, OXTR, ESR1, PGR
21mifepristone43 28 59 1212.1CYP19A1, GNRH1, PGR, ESR2, ESR1, OXTR
22letrozole43 49 59 1212.1ESR1, CYP19A1, ESR2, PGR
23dihydrotestosterone43 28 24 1212.1CYP19A1, DES, PGR, ESR2, GNRH1, ESR1
24procollagen439.1PCNA, ACTC1, VIM, DES, ADM
25doxorubicin43 49 1211.1CYP19A1, DES, VIM, ESR2, PGR, ESR1
26formaldehyde43 2410.0PCNA, ACTC1, DES, GNRH1, CYP19A1, VIM
27b 723439.0PCNA, DES, ACTC1, S100A1, VIM
28hematoxylin438.9DES, S100A1, PCNA, VIM, ACTC1
295fluorouracil438.8ESR1, PCNA, CYP19A1, GNRH1, PGR, TGFB3
30gnrh438.6ESR1, ESR2, TGFB3, PGR, VIM, GNRH1
31ribonucleic acid438.6ACTC1, OXTR, MYOG, ESR2, PGR, TGFB3
32genistein43 28 59 2 24 1213.5ESR2, CYP19A1, PGR, ESR1, PCNA, VIM
33indomethacin43 28 59 1211.5PCNA, CCL11, OXTR, VIM, CYP19A1, PGR
34progestin438.4OXTR, DES, CYP19A1, GNRH1, TGFB3, PGR
35adenylate438.3PGR, DES, OXTR, ADM, MYOG, VIM
36creatinine438.3DES, GNRH1, PCNA, VIM, FH, MYOG
37tamoxifen43 49 28 1211.1PGR, ADM, GNRH1, OXTR, PCNA, VIM
38estradiol43 24 129.9CYP19A1, GNRH1, TGFB3, PGR, ESR2, ESR1
39actinomycin d437.9VIM, ADM, CCL11, HMGA2, ESR1, ESR2
40arginine437.8CYP19A1, GNRH1, OXTR, DES, VIM, ADM
41thymidine43 248.5PCNA, CCL11, OXTR, DES, TGFB3, CYR61
42dexamethasone43 49 28 1210.4TGFB3, ESR2, VIM, PGR, CYP19A1, PCNA
43paraffin437.0HMGA2, S100A1, PCNA, ACTC1, ADM, MYOG
44cysteine436.9PCNA, MYOG, VIM, ESR2, PGR, CYR61
45testosterone43 59 24 129.9TGFB3, GNRH1, CYP19A1, DES, ESR1, VIM
46steroid436.5ACTC1, CCL11, OXTR, ADM, MYOG, ESR1
47vegf436.2PCNA, ACTC1, CCL11, OXTR, ADM, MYOG
48retinoic acid43 247.0HMGA2, S100A1, PCNA, ACTC1, CCL11, ADM
49progesterone43 28 59 24 129.9ACTC1, OXTR, ADM, VIM, ESR1, ESR2
50estrogen435.4MYOG, ESR1, ESR2, PGR, TGFB3, GNRH1

GO Terms for genes affiliated with Leiomyoma

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Cellular components related to Leiomyoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein-DNA complexGO:00329939.4MYOG, HMGA2
2nucleoplasmGO:00056548.4HMGA2, PCNA, MYOG, ESR1, ESR2, PGR
3extracellular regionGO:00055768.1CCL11, ADM, ESR2, TGFB3, GNRH1, CYR61

Biological processes related to Leiomyoma according to GeneCards Suite gene sharing:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1uterus developmentGO:006006510.2ESR1, ESR2
2vagina developmentGO:006006810.2ESR2, ESR1
3muscle filament slidingGO:003004910.1DES, VIM, ACTC1
4androgen metabolic processGO:000820910.0ADM, ESR1, CYP19A1
5intracellular estrogen receptor signaling pathwayGO:003052010.0ESR1, ESR2
6positive regulation of sequence-specific DNA binding transcription factor activityGO:005109110.0HMGA2, ESR1, ESR2
7cellular response to estradiol stimulusGO:00713929.9MYOG, ESR1
8ERK1 and ERK2 cascadeGO:00703719.8OXTR, CCL11
9digestive tract developmentGO:00485659.8OXTR, TGFB3
10positive regulation of cell cycle arrestGO:00711589.7HMGA2, MYOG
11positive regulation of cytosolic calcium ion concentrationGO:00072049.7ESR1, ADM, OXTR
12cell-cell signalingGO:00072679.6ADM, ESR2, PGR, GNRH1
13female pregnancyGO:00075659.5GNRH1, TGFB3, ADM, OXTR
14negative regulation of cell proliferationGO:00082859.3ADM, MYOG, TGFB3, GNRH1
15heart developmentGO:00075079.1ADM, OXTR, PCNA
16positive regulation of apoptotic processGO:00430659.1CYR61, TGFB3, ADM, HMGA2
17signal transductionGO:00071658.9GNRH1, PGR, ESR2, ESR1, ADM, CCL11
18negative regulation of apoptotic processGO:00430668.7HMGA2, ACTC1, GNRH1, CYR61
19positive regulation of transcription from RNA polymerase II promoterGO:00459448.6HMGA2, MYOG, ESR1, TGFB3, CYR61

Molecular functions related to Leiomyoma according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1estrogen response element bindingGO:003405610.0ESR1, ESR2
2estrogen receptor activityGO:00302849.9ESR1, ESR2
3core promoter sequence-specific DNA bindingGO:00010469.9ESR1, ESR2
4steroid bindingGO:00054969.9ESR1, ESR2, PGR
5steroid hormone receptor activityGO:00037079.8PGR, ESR2, ESR1
6enzyme bindingGO:00198999.4PGR, ESR2, ESR1, HMGA2
7identical protein bindingGO:00428028.5S100A1, DES, TGFB3, ESR1, VIM, PCNA
8protein bindingGO:00055156.6DES, TGFB3, PGR, ESR2, ESR1, VIM

Products for genes affiliated with Leiomyoma

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Sources for Leiomyoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet