Aliases & Classifications for Leiomyoma

Aliases & Descriptions for Leiomyoma:

Name: Leiomyoma 12 52 42 14
Leiomyomatous Neoplasm 12
Leiomyomatous Tumor 12
Uterine Fibroids 69
Fibroid Tumor 69

Classifications:



External Ids:

Disease Ontology 12 DOID:127
MeSH 42 D007889
NCIt 47 C3157
ICD10 33 D25.9
UMLS 69 C0023267

Summaries for Leiomyoma

Disease Ontology : 12 A cell type benign neoplasm that is a benign tumor of smooth muscle cells.

MalaCards based summary : Leiomyoma, also known as leiomyomatous neoplasm, is related to appendix leiomyoma and pericardium leiomyoma, and has symptoms including pelvic pain An important gene associated with Leiomyoma is FH (Fumarate Hydratase), and among its related pathways/superpathways are TGF-beta Signaling Pathways and AGE-RAGE signaling pathway in diabetic complications. The drugs Hyaluronic acid and Goserelin have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, uterus and lung, and related phenotypes are Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) and homeostasis/metabolism

Wikipedia : 71 A leiomyoma, also known as fibroids, is a benign smooth muscle tumor that very rarely becomes cancer... more...

Related Diseases for Leiomyoma

Diseases related to Leiomyoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 341)
id Related Disease Score Top Affiliating Genes
1 appendix leiomyoma 33.1 ESR1 PGR
2 pericardium leiomyoma 32.9 ACTC1 PGR
3 gastrointestinal stromal tumor 31.8 ACTC1 CD34 DES MKI67 S100A1
4 plexiform neurofibroma 29.7 ESR1 PGR
5 malignant mixed mullerian tumor 29.5 DES HMGA2 S100A1
6 benign metastasizing leiomyoma 12.1
7 bizarre leiomyoma 11.9
8 leiomyoma cutis 11.9
9 leiomyomatosis and renal cell cancer 11.9
10 gastric leiomyoma 11.9
11 uterine fibroid 11.9
12 bladder leiomyoma 11.9
13 prostate leiomyoma 11.8
14 liver leiomyoma 11.8
15 small intestine leiomyoma 11.8
16 lung leiomyoma 11.8
17 gallbladder leiomyoma 11.8
18 vulvar leiomyoma 11.8
19 multiple cutaneous and uterine leiomyomas 11.8
20 colon leiomyoma 11.8
21 deep leiomyoma 11.8
22 uterus interstitial leiomyoma 11.8
23 endobronchial leiomyoma 11.8
24 breast leiomyoma 11.8
25 esophagus leiomyoma 11.8
26 orbital leiomyoma 11.7
27 ureter leiomyoma 11.7
28 leiomyoma, uterine, somatic 11.7
29 trachea leiomyoma 11.7
30 extrahepatic bile duct leiomyoma 11.7
31 central nervous system leiomyoma 11.7
32 urethra leiomyoma 11.7
33 large bowel leiomyoma 11.7
34 uterine corpus bizarre leiomyoma 11.7
35 mediastinum leiomyoma 11.6
36 fallopian tube leiomyoma 11.6
37 rectum leiomyoma 11.6
38 uterine corpus apoplectic leiomyoma 11.6
39 anus leiomyoma 11.6
40 uterine corpus epithelioid leiomyoma 11.6
41 larynx leiomyoma 11.6
42 uterine corpus dissecting leiomyoma 11.6
43 vagina leiomyoma 11.6
44 uterine corpus myxoid leiomyoma 11.6
45 dartoic leiomyoma 11.6
46 leiomyoma of vulva and esophagus 11.6
47 leiomyosarcoma 11.5
48 submucous uterine fibroid 11.2
49 renal cell carcinoma 11.2
50 subserous uterine fibroid 11.1

Graphical network of the top 20 diseases related to Leiomyoma:



Diseases related to Leiomyoma

Symptoms & Phenotypes for Leiomyoma

UMLS symptoms related to Leiomyoma:


pelvic pain

GenomeRNAi Phenotypes related to Leiomyoma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 9.02 ESR1 ESR2 FH IGF2 MKI67

MGI Mouse Phenotypes related to Leiomyoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.21 GNRH1 IGF2 MME PGR S100A1 TGFB3
2 cellular MP:0005384 10.2 ACTC1 CD34 CYP19A1 DES ESR1 ESR2
3 cardiovascular system MP:0005385 10.18 ACTC1 COL4A5 CYP19A1 DES ESR1 ESR2
4 hematopoietic system MP:0005397 10.1 CD34 COL4A5 CYP19A1 ESR1 ESR2 GNRH1
5 immune system MP:0005387 10.06 CD34 COL4A5 CYP19A1 ESR1 ESR2 GNRH1
6 digestive/alimentary MP:0005381 9.98 CYP19A1 ESR1 ESR2 GNRH1 IGF2 IL17B
7 integument MP:0010771 9.91 CD34 CYP19A1 DPT ESR1 ESR2 GNRH1
8 muscle MP:0005369 9.76 ESR2 IGF2 PGR S100A1 ACTC1 CYP19A1
9 normal MP:0002873 9.65 ACTC1 COL4A6 CYP19A1 ESR1 ESR2 GNRH1
10 renal/urinary system MP:0005367 9.17 COL4A5 CYP19A1 ESR1 ESR2 FH GNRH1

Drugs & Therapeutics for Leiomyoma

Drugs for Leiomyoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 255)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741 24759
2
Goserelin Approved Phase 4,Phase 3,Phase 2 65807-02-5 47725 5311128
3
Calcium carbonate Approved Phase 4,Phase 3 471-34-1
4
Desogestrel Approved Phase 4 54024-22-5 40973
5
Nandrolone decanoate Approved, Illicit Phase 4 360-70-3 9677
6
Nandrolone Approved, Experimental, Illicit Phase 4 434-22-0, 62-90-8 9904 229455
7
Leuprolide Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 53714-56-0 3911 657181
8
Dimenhydrinate Approved Phase 4 523-87-5 441281
9 Dienogest Approved Phase 4 65928-58-7
10
Ethanol Approved Phase 4 64-17-5 702
11
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
12
Zinc Approved Phase 4 7440-66-6 32051 23994
13
Progesterone Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 57-83-0 5994
14
Morphine Approved, Investigational Phase 4 57-27-2 5288826
15
Acetaminophen Approved Phase 4 103-90-2 1983
16
Ibuprofen Approved Phase 4 15687-27-1 3672
17
Misoprostol Approved Phase 4,Phase 3,Phase 2 59122-46-2 5282381
18
Lidocaine Approved, Vet_approved Phase 4,Phase 2 137-58-6 3676
19
Letrozole Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 112809-51-5 3902
20
Remifentanil Approved Phase 4 132875-61-7 60815
21
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
22
Cetrorelix Approved, Investigational Phase 4 120287-85-6 16129715 25074887
23
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
24
Benzocaine Approved Phase 4 1994-09-7, 94-09-7 2337
25
Hydroxocobalamin Approved Phase 4 13422-51-0 11953898 5460373 44475014
26
Dinoprostone Approved Phase 4 363-24-6 5280360
27
Prilocaine Approved Phase 4 721-50-6 4906
28
Zinc oxide Approved Phase 4 1314-13-2
29
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
30
Tranexamic Acid Approved Phase 4,Phase 3,Phase 1 1197-18-8 5526
31
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
32
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
33
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
34
Vitamin C Approved, Nutraceutical Phase 4,Phase 3 50-81-7 5785 54670067
35
Pyridoxine Approved, Nutraceutical, Vet_approved Phase 4 65-23-6 1054
36
Niacin Approved, Investigational, Nutraceutical Phase 4 59-67-6 938
37
leucovorin Approved, Nutraceutical Phase 4 58-05-9 54575, 6560146 143
38
Riboflavin Approved, Nutraceutical, Vet_approved Phase 4 83-88-5 493570
39
Nicotinamide Approved, Nutraceutical Phase 4 98-92-0 936
40
Thiamine Approved, Nutraceutical, Vet_approved Phase 4 59-43-8 1130
41
Pyridoxal Approved, Nutraceutical Phase 4 66-72-8 1050
42 tannic acid Approved, Nutraceutical Phase 4
43
Cholecalciferol Approved, Nutraceutical Phase 4 67-97-0 6221 10883523 5280795
44
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
45
Cyanocobalamin Approved, Nutraceutical Phase 4 68-19-9 44176380
46
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
47 Progestins Phase 4,Phase 3,Phase 2,Phase 1
48 Adjuvants, Immunologic Phase 4
49 Gastrointestinal Agents Phase 4,Phase 3
50 Steroid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 306)
id Name Status NCT ID Phase
1 Study of the Efficacy of Dienogest in the Treatment of Uterine Leiomyomas When Compared to Desogestrel and Goserelin Unknown status NCT01738724 Phase 4
2 High Intensity Focused Ultrasound Ablation Virus Myomectomy to Treat Uterine Fibroids Unknown status NCT01239641 Phase 4
3 MyoSure Hysteroscopic Tissue Removal System Registry Study Unknown status NCT01369758 Phase 4
4 Ambulatory Oxygen in Fibrotic Lung Disease (FLD) (AmbOx) Unknown status NCT02286063 Phase 4
5 Seprafilm Slurry in the Prevention of Uterine Scarring in Patients Undergoing Hysteroscopic Myomectomy Unknown status NCT01632202 Phase 4
6 Fibroids in Women of Reproductive Age and Women Pregnancy Completed NCT02620345 Phase 4
7 Novel MRI Strategies as a Non-invasive Biomarker in Women With Uterine Fibroids Completed NCT00746031 Phase 4
8 A Prospective Study Comparing Contour SE™ Microspheres to Embosphere® Microspheres for Treating Symptomatic Uterine Fibroids With Uterine Fibroid Embolization (UFE) Completed NCT00628901 Phase 4
9 MR Guided Focused Ultrasound Surgery in the Treatment of Uterine Fibroids Completed NCT00166270 Phase 4
10 Efficacy Study of Magnetic Resonance (MR) Guided Focused Ultrasound in the Treatment of Large Fibroids Completed NCT00159328 Phase 4
11 Safety Study of ExAblate for the Treatment of Uterine Fibroids Completed NCT01142791 Phase 4
12 Intra-arterial Lidocaine for Pain Control Post Uterine Fibroid Embolization Completed NCT02293447 Phase 4
13 Safety Trial of Magnetic Resonance (MR) Guided Focused Ultrasound Surgery (FUS) in Women With Uterine Fibroids Wishing to Pursue Pregnancy in the Future Completed NCT00180739 Phase 4
14 Effectiveness of IV Acetaminophen and IV Ibuprofen in Reducing Post Procedural Pain in the UFE Procedure Completed NCT02227316 Phase 4
15 Randomized Controlled Trial (RCT)Comparing GYNAECARE MORCELLEX Versus ROTOCUT GI Tissue Morcellators Completed NCT00743080 Phase 4
16 Efficacity Assessment of PREVADH® in Adhesion Prevention in Gynaecologic Surgery Completed NCT01388907 Phase 4
17 Vasopressin Administration During Laparoscopic Myomectomy: a Randomized Controlled Trial Completed NCT01393704 Phase 4
18 Intravenous or Intra-abdominal Local Anesthetics for Postoperative Pain Management. Completed NCT01492179 Phase 4
19 Comparing Two Types of Sedation to Gynaecological Patients Completed NCT01412632 Phase 4
20 Single Versus Double Dose Intra-vaginal Prostaglandin E2 "Misoprostol" Prior Abdominal Myomectomy Completed NCT02154932 Phase 4
21 Ulipristal Acetate for the Preoperative Management of Hypoechoic Cellular Leiomyomas Recruiting NCT02361905 Phase 4
22 Ulipristal Acetate Versus GnRH Analogue Treatment Before Hysteroscopic Resection of Uterine Leiomyoma Recruiting NCT02361879 Phase 4
23 Ulipristal Acetate Versus GnRH Analogue and Myometrial Preservation Recruiting NCT02357563 Phase 4
24 Misoprostol for Reduction of Blood Loss During Fibroid Surgery Recruiting NCT02209545 Phase 4
25 Ulipristal Use in Chinese Population Recruiting NCT02825719 Phase 4
26 Ulipristal vs. GnRHa Prior to Laparoscopic Myomectomy Recruiting NCT02288130 Phase 4
27 The Effect of Ulipristal Acetate (UPA) on Women Ovarian Reserve Recruiting NCT02361892 Phase 4
28 Surgical Success After Laparoscopic vs Abdominal Hysterectomy Recruiting NCT01793584 Phase 4
29 Deep Versus Moderate Neuromuscular Blockade During Laparoscopic Surgery Recruiting NCT02812186 Phase 4
30 Uterine Leiomyoma Treatment With Radiofrequency Ablation Active, not recruiting NCT01840124 Phase 4
31 Pilot of Letrozole for Uterine Myomas Active, not recruiting NCT02470741 Phase 4
32 The FIRSTT: Comparing MRgFUS(MR-guided Focused Ultrasound) Versus UAE (Uterine Artery Embolization)for Uterine Fibroids. Active, not recruiting NCT00995878 Phase 4
33 Laparoscopic Uterine Sparing Techniques Outcomes and Reinterventions Active, not recruiting NCT01750008 Phase 4
34 Feasibility and Yield of a New 20 G ProCore Needle With Coiled Sheath in the Gastrointestinal Subepithelial Tumors Enrolling by invitation NCT02884154 Phase 4
35 IVF Outcome Following Treatment With Ulipristal Acetate for Myomatous Uterus After at Least One IVF Failure Not yet recruiting NCT02601196 Phase 4
36 Endometrial Preparation Before Operative Hysteroscopy in Premenopausal Women Not yet recruiting NCT02440750 Phase 4
37 ExAblate Treatment of Uterine Fibroids for Fertility Enhancement Terminated NCT00730886 Phase 4
38 Study to Evaluate the Safety and Effectiveness of MRgFUS Compared With Myomectomy for the Treatment of Uterine Fibroids Terminated NCT01328067 Phase 4
39 Uterine Fibroid Pregnancy Registry Terminated NCT00232713 Phase 4
40 Preemptive Analgesia Following Uterine Artery Embolization Terminated NCT01555073 Phase 4
41 Peritoneal Cavity Conditioning Decreases Pain, Inflammation and Adhesions Terminated NCT01344486 Phase 4
42 Influence of Aromatase Inhibitors and GnRH Analogs to Treat Uterine Leiomyoma by Vaginal Hysterectomy Unknown status NCT01280045 Phase 3
43 Study of Tumor-shrinking Decoction (TSD) to Treat Symptomatic Uterine Fibroids Unknown status NCT02189083 Phase 3
44 Study on the Effect of Intravenous Ascorbic Acid on Intraoperative Blood Loss in Women With Uterine Myoma Unknown status NCT01715597 Phase 3
45 The Use of Doppler to Diagnose Myometrial Masses Unknown status NCT01833871 Phase 2, Phase 3
46 Single Incision Laparoscopic Surgery (SILS) Versus Conventional Laparoscopic Hysterectomy Unknown status NCT01483417 Phase 3
47 Single-port Access Laparoscopic-assisted Vaginal Hysterectomy Unknown status NCT01048931 Phase 3
48 Long Term Prevention of Nausea and Vomiting in Gynecologic Laparoscopy Unknown status NCT02011659 Phase 3
49 Understanding Experimentally Induced Hot Flushes Unknown status NCT00455689 Phase 2, Phase 3
50 Therapeutic MRI Guided High Intensity Focused Ultrasound Ablation of Uterine Fibroids Completed NCT01141062 Phase 3

Search NIH Clinical Center for Leiomyoma

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: leiomyoma

Genetic Tests for Leiomyoma

Anatomical Context for Leiomyoma

MalaCards organs/tissues related to Leiomyoma:

39
Smooth Muscle, Uterus, Lung, Breast, Prostate, Endothelial, Ovary

Publications for Leiomyoma

Articles related to Leiomyoma:

(show top 50) (show all 1589)
id Title Authors Year
1
A Case of Simultaneous Benign Metastasizing Leiomyomas and Disseminated Peritoneal Leiomyomatosis Following Endoscopic Power Morcellation for Uterine Disease. ( 27748666 )
2017
2
Catechol-O-methyltransferase Val158Met polymorphism is associated with increased risk of multiple uterine leiomyomas either positive or negative for MED12 exon 2 mutations. ( 27491313 )
2017
3
The effect of uterine leiomyoma on the risk of malpresentation and cesarean: a meta-analysis. ( 28027686 )
2017
4
Endoscopic Laser Management of a Leiomyoma of the Left Main Stem Bronchus. ( 27984395 )
2017
5
Giant leiomyoma with extensive myxoid degeneration in Mayer-Rokitansky-KA1ster-Hauser syndrome. ( 28369817 )
2017
6
Leiomyoma of the Palpebral Conjunctiva. ( 27993264 )
2017
7
Massive Broad Ligament Cellular Leiomyoma with Cystic Change: A Diagnostic Dilemma. ( 27190813 )
2016
8
Halofuginone suppresses growth of human uterine leiomyoma cells in a mouse xenograft model. ( 27130615 )
2016
9
Cecal Leiomyoma: Can We Attempt Endoscopic Resection? ( 28058080 )
2016
10
Angiomyomatous Leiomyoma of a Female Urethral Meatus Recurrence After Seven Years of the Resection: A Case Report. ( 27656416 )
2016
11
Genetic variability within Adenosine Deaminase gene and uterine leiomyomas. ( 26918693 )
2016
12
Extraperitoneal leiomyoma of the round ligament of the uterus mimicking adnexal mass. ( 27960563 )
2016
13
Association of FAS A-670G Polymorphism and Risk of Uterine Leiomyoma in a Southeast Iranian Population. ( 28070535 )
2016
14
Benign metastasizing leiomyoma in triple location: lungs, parametria and appendix. ( 27582687 )
2016
15
Mitotically Active Leiomyoma in a Woman with Mayer-Rokitansky-KA1ster-Hauser Syndrome: A Case Report. ( 27424377 )
2016
16
Rare mediastinal leiomyoma in a child. ( 27640051 )
2016
17
Iatrogenic parasitic leiomyoma and leiomyomatosis peritonealis disseminata following uterine morcellation. ( 27125448 )
2016
18
Seminal Vesicle Leiomyoma Mimicking Extra-prostatic Extension ofA Prostatic Adenocarcinoma. ( 27169020 )
2016
19
The study of MED12 gene mutations in uterine leiomyomas from Iranian patients. ( 26298726 )
2016
20
G-protein-coupled estrogen receptor-30 gene polymorphisms are associated with uterine leiomyoma risk. ( 26773178 )
2016
21
Interstitial Cells of Cajal in Deep Esophageal Leiomyoma: Immunohistochemical Mimics of Gastrointestinal Stromal Tumor. ( 27422468 )
2016
22
Round Ligament Leiomyoma Presenting as an Incarcerated Inguinal Hernia: Case Report and Review of the Literature. ( 27144048 )
2016
23
Strong Association Between Endometriosis and Symptomatic Leiomyomas. ( 27647977 )
2016
24
EP32.06: Study of contrast-enhanced ultrasound in evaluating clinical therapeutic response with high intensity focused ultrasound for uterine leiomyoma and follow-up result. ( 27647516 )
2016
25
Leiomyoma in a Renal Allograft. ( 27195169 )
2016
26
MicroRNA-15b regulates reversion-inducing cysteine-rich protein with Kazal motifs (RECK) expression in human uterine leiomyoma. ( 27530410 )
2016
27
Randomized controlled trial of thermal balloon ablation versus vaginal hysterectomy for leiomyoma-induced heavy menstrual bleeding. ( 27575538 )
2016
28
Conjunctival Leiomyoma; a Rare Tumor of the Ocular Surface. ( 27994813 )
2016
29
Uterine angioleiomyoma - a rare variant of uterine leiomyoma: review of literature and case reports. ( 27980528 )
2016
30
A Rare Case of Intra-Endometrial Leiomyoma of Uterus Simulating Degenerated Submucosal Leiomyoma Accompanied by a Large Sertoli-Leydig Cell Tumor. ( 26847310 )
2016
31
Submucosal tunneling endoscopic resection of a symptomatic leiomyoma in the proximal esophagus. ( 27997960 )
2016
32
Vascular leiomyoma of the nasal cavity: case report and literature review. ( 27164945 )
2016
33
Somatic MED12 mutations in prostate cancer and uterine leiomyomas promote tumorigenesis through distinct mechanisms. ( 26383637 )
2016
34
Perineal leiomyoma in a postmenopausal woman: A case report. ( 27602136 )
2016
35
Silencing Med12 Gene Reduces Proliferation of Human Leiomyoma Cells Mediated via Wnt/I^-Catenin Signaling Pathway. ( 27967206 )
2016
36
Leiomyoma of Urinary Bladder Presenting with Febrile Urinary Tract Infection: A Case Report. ( 27621100 )
2016
37
A rare cause of miliary pattern and respiratory failure - Benign metastasizing leiomyoma. ( 27178355 )
2016
38
Young man with dyspnoea for 6a88months; presenting with subacute tracheal obstruction due to leiomyoma. ( 27587746 )
2016
39
Immunohistochemistry for 2-Succinocysteine (2SC) and Fumarate Hydratase (FH) in Cutaneous Leiomyomas May Aid in Identification of Patients With HLRCC (Hereditary Leiomyomatosis and Renal Cell Carcinoma Syndrome). ( 26945337 )
2016
40
Multiple asymptomatic cutaneous pilar leiomyoma versus spontaneous eruptive keloids - a case report. ( 27151722 )
2016
41
Laparoscopic Transgastric Enucleation of a Gastric Leiomyoma near the Esophagogastric Junction and Concomitant Sleeve Gastrectomy: Video Report. ( 26883931 )
2016
42
The effects of p21 gene C98A polymorphism on development of uterine leiomyoma in southeast Iranian women. ( 27337955 )
2016
43
Uterine leiomyoma in a 19-year-old girl: Case report and literature review. ( 27217916 )
2016
44
Uterine Fibroid (Leiomyoma) with Acute Urinary Retention: A Case Series. ( 27190903 )
2016
45
Diffusion-Weighted Imaging for Differentiating Uterine Leiomyosarcoma From Degenerated Leiomyoma. ( 27997438 )
2016
46
Leiomyoma and leiomyoma cellulare of the fallopian tube: review of the literature and case reports. ( 27980525 )
2016
47
Giant oesophageal leiomyoma causing severe hypertension. ( 27624448 )
2016
48
Partial gastrectomy for resection of a gastric leiomyoma in a guinea pig (Cavia porcellus). ( 27901456 )
2016
49
Treatment decision based on the biological behavior of pulmonary benign metastasizing leiomyoma. ( 27621897 )
2016
50
Intraosseous leiomyoma of the calcaneum: An unusual bone tumor of foot and review of literature. ( 28018075 )
2016

Variations for Leiomyoma

Expression for Leiomyoma

Search GEO for disease gene expression data for Leiomyoma.

Pathways for Leiomyoma

GO Terms for Leiomyoma

Cellular components related to Leiomyoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 CD34 COL4A5 COL4A6 ESR2 GNRH1 IGF2
2 collagen type IV trimer GO:0005587 8.62 COL4A5 COL4A6

Biological processes related to Leiomyoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.5 ESR1 ESR2 HMGA2
2 androgen metabolic process GO:0008209 9.37 CYP19A1 ESR1
3 uterus development GO:0060065 9.26 CYP19A1 ESR1
4 collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 9.16 COL4A5 COL4A6
5 steroid hormone mediated signaling pathway GO:0043401 9.13 ESR1 ESR2 PGR
6 paracrine signaling GO:0038001 8.62 CD34 PGR

Molecular functions related to Leiomyoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 ATPase binding GO:0051117 9.58 ESR1 PGR S100A1
2 steroid hormone receptor activity GO:0003707 9.54 ESR1 ESR2 PGR
3 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0004879 9.43 ESR1 ESR2 PGR
4 estrogen receptor activity GO:0030284 9.32 ESR1 ESR2
5 estrogen response element binding GO:0034056 9.16 ESR1 ESR2
6 steroid binding GO:0005496 9.13 ESR1 ESR2 PGR
7 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding GO:0038052 8.62 ESR1 ESR2

Sources for Leiomyoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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