Aliases & Classifications for Leiomyoma

MalaCards integrated aliases for Leiomyoma:

Name: Leiomyoma 12 72 51 41 14
Leiomyomatous Neoplasm 12
Leiomyomatous Tumor 12
Uterine Fibroids 69
Fibroid Tumor 69

Classifications:



External Ids:

Disease Ontology 12 DOID:127
MeSH 41 D007889
NCIt 46 C3157
ICD10 32 D25.9
UMLS 69 C0023267

Summaries for Leiomyoma

Disease Ontology : 12 A cell type benign neoplasm that is a benign tumor of smooth muscle cells.

MalaCards based summary : Leiomyoma, also known as leiomyomatous neoplasm, is related to lung leiomyoma and vulvar leiomyoma, and has symptoms including pelvic pain An important gene associated with Leiomyoma is HMGA2 (High Mobility Group AT-Hook 2), and among its related pathways/superpathways are Gastric cancer and Pathways in cancer. The drugs Desogestrel and Dienogest have been mentioned in the context of this disorder. Affiliated tissues include uterus, smooth muscle and prostate, and related phenotypes are Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) and homeostasis/metabolism

Wikipedia : 72 A leiomyoma, also known as fibroids, is a benign smooth muscle tumor that very rarely becomes cancer... more...

Related Diseases for Leiomyoma

Diseases related to Leiomyoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 385)
# Related Disease Score Top Affiliating Genes
1 lung leiomyoma 33.9 ESR1 PGR
2 vulvar leiomyoma 33.9 ESR1 PGR
3 benign metastasizing leiomyoma 33.9 ACTC1 CYP19A1 DES PGR
4 bizarre leiomyoma 33.8 ACTC1 PGR
5 orbital leiomyoma 33.6 GNRH1 S100A1
6 leiomyoma, uterine 33.0 CYP19A1 ESR1 ESR2 FH GNRH1 HMGA2
7 leiomyosarcoma 32.5 ACTC1 DES FH IGF2 PGR
8 gastrointestinal stromal tumor 31.8 ACTC1 CD34 DES MKI67 S100A1
9 lymphangioleiomyomatosis 30.5 DES ESR1 PGR
10 mesenchymoma 30.4 DES HMGA2
11 endometriosis 30.3 CYP19A1 ESR1 ESR2 GNRH1 PGR
12 gynecomastia 30.3 CYP19A1 ESR1 PGR
13 myoma 30.2 CYP19A1 ESR1 GNRH1 HMGA2 PGR
14 liposarcoma 30.1 CD34 DES HMGA2
15 intravenous leiomyomatosis 30.1 DES ESR1 MME
16 myxoid leiomyosarcoma 30.0 ACTC1 PGR
17 infertility 30.0 CYP19A1 ESR2 GNRH1 PGR
18 cutaneous leiomyosarcoma 30.0 ACTC1 DES FH
19 hemangiopericytoma, malignant 30.0 ACTC1 DES IGF2
20 prostatic hypertrophy 30.0 CYP19A1 ESR1 PGR
21 endometriosis of ovary 29.9 CYP19A1 ESR1 ESR2 PGR
22 leiomyomatosis 29.9 COL4A5 COL4A6 ESR1 FH GNRH1 PGR
23 uterine sarcoma 29.9 CYP19A1 DES ESR1 MME
24 trigonitis 29.8 CD34 ESR1 PGR
25 angiomyolipoma 29.8 ACTC1 DES ESR1 PGR
26 glomangiomyoma 29.8 ACTC1 CD34 ESR1
27 small intestinal sarcoma 29.7 CD34 IGF2
28 dermatofibrosarcoma protuberans 29.7 ACTC1 CD34 DES
29 smooth muscle tumor 29.5 ACTC1 DES ESR1 HMGA2 MME PGR
30 endometrial stromal nodule 29.3 CYP19A1 MME PGR
31 endometrial stromal sarcoma 29.3 ACTC1 CYP19A1 DES ESR1 MME PGR
32 perivascular epithelioid cell tumor 29.1 ACTC1 DES MME PGR
33 endometrial cancer 28.4 CYP19A1 ESR1 ESR2 GNRH1 MKI67 MME
34 hereditary leiomyomatosis and renal cell cancer 12.0
35 leiomyoma cutis 12.0
36 gastric leiomyoma 12.0
37 bladder leiomyoma 12.0
38 prostate leiomyoma 12.0
39 small intestine leiomyoma 12.0
40 trachea leiomyoma 12.0
41 gallbladder leiomyoma 12.0
42 liver leiomyoma 12.0
43 colon leiomyoma 11.9
44 urethra leiomyoma 11.9
45 deep leiomyoma 11.9
46 appendix leiomyoma 11.9
47 endobronchial leiomyoma 11.9
48 uterus interstitial leiomyoma 11.9
49 breast leiomyoma 11.9
50 larynx leiomyoma 11.9

Graphical network of the top 20 diseases related to Leiomyoma:



Diseases related to Leiomyoma

Symptoms & Phenotypes for Leiomyoma

UMLS symptoms related to Leiomyoma:


pelvic pain

GenomeRNAi Phenotypes related to Leiomyoma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 9.1 ESR1 ESR2 FH IGF2 MKI67 RAD51B

MGI Mouse Phenotypes related to Leiomyoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.21 CYP19A1 FH GNRH1 DES IGF2 ESR1
2 cellular MP:0005384 10.17 ESR2 FH CYP19A1 DES ACTC1 ESR1
3 cardiovascular system MP:0005385 10.16 ESR2 CYP19A1 DES ACTC1 ESR1 COL4A5
4 immune system MP:0005387 10.06 ESR2 CYP19A1 GNRH1 ESR1 CD34 COL4A5
5 digestive/alimentary MP:0005381 9.95 ESR2 CYP19A1 GNRH1 ESR1 TGFB3 IGF2
6 integument MP:0010771 9.91 CYP19A1 GNRH1 DPT ESR1 CD34 ESR2
7 muscle MP:0005369 9.76 CYP19A1 DES ACTC1 ESR1 ESR2 PGR
8 normal MP:0002873 9.65 COL4A6 CYP19A1 GNRH1 ESR1 ACTC1 ESR2
9 renal/urinary system MP:0005367 9.17 COL4A5 ESR2 FH CYP19A1 GNRH1 ESR1

Drugs & Therapeutics for Leiomyoma

Drugs for Leiomyoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 258)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Desogestrel Approved Phase 4 54024-22-5 40973
2
Dienogest Approved Phase 4 65928-58-7
3
Goserelin Approved Phase 4,Phase 3,Phase 2 65807-02-5 5311128 47725
4
Nandrolone Approved, Experimental, Illicit, Investigational Phase 4 62-90-8, 434-22-0 9904 229455
5
Nandrolone decanoate Approved, Illicit Phase 4 360-70-3 9677
6
Dimenhydrinate Approved Phase 4 523-87-5 441281
7
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741 24759
8
Calcium Carbonate Approved, Investigational Phase 4,Phase 3 471-34-1
9
Leuprolide Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 53714-56-0 657181 3911
10
Anastrozole Approved, Investigational Phase 4,Phase 3 120511-73-1 2187
11
Hydroxocobalamin Approved Phase 4 13422-51-0 5460373 44475014 11953898
12
Zinc Approved, Investigational Phase 4 7440-66-6 32051 23994
13
Zinc oxide Approved Phase 4 1314-13-2
14
Cetrorelix Approved, Investigational Phase 4 120287-85-6 25074887 16129715
15
Ethanol Approved Phase 4 64-17-5 702
16
Lidocaine Approved, Vet_approved Phase 4,Phase 2 137-58-6 3676
17
Acetaminophen Approved Phase 4 103-90-2 1983
18
Ibuprofen Approved Phase 4 15687-27-1 3672
19
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
20
Morphine Approved, Investigational Phase 4 57-27-2 5288826
21
Prilocaine Approved Phase 4 721-50-6 4906
22
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
23
Remifentanil Approved Phase 4 132875-61-7 60815
24
Dinoprostone Approved Phase 4 363-24-6 5280360
25
Misoprostol Approved Phase 4,Phase 3,Phase 2 59122-46-2 5282381
26
Mifepristone Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 84371-65-3 55245
27
Levonorgestrel Approved, Investigational Phase 4,Phase 2 797-63-7, 17489-40-6 13109
28
Progesterone Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 57-83-0 5994
29
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
30
Letrozole Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 112809-51-5 3902
31
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
32
Tranexamic Acid Approved Phase 4,Phase 3,Phase 1 1197-18-8 5526
33
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
34
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
35
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
36
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
37
Glycine Approved, Nutraceutical, Vet_approved Phase 4 56-40-6 750
38
B-Carotene Approved, Nutraceutical Phase 4 7235-40-7 5280489
39
Cholecalciferol Approved, Nutraceutical Phase 4 67-97-0 10883523 5280795 6221
40
Cyanocobalamin Approved, Nutraceutical Phase 4 68-19-9 44176380
41
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
42
leucovorin Approved, Nutraceutical Phase 4 58-05-9 143 6006
43
Methylcobalamin Approved, Experimental, Investigational, Nutraceutical Phase 4 13422-55-4
44
Niacin Approved, Investigational, Nutraceutical Phase 4 59-67-6 938
45
Nicotinamide Approved, Investigational, Nutraceutical Phase 4 98-92-0 936
46
Pyridoxal Approved, Nutraceutical Phase 4 66-72-8 1050
47
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 4 65-23-6 1054
48
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 4 83-88-5 493570
49
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 4 59-43-8 1130
50 Tocopherol Approved, Investigational, Nutraceutical Phase 4

Interventional clinical trials:

(show top 50) (show all 334)

# Name Status NCT ID Phase Drugs
1 Study of the Efficacy of Dienogest in the Treatment of Uterine Leiomyomas When Compared to Desogestrel and Goserelin Unknown status NCT01738724 Phase 4 Dienogest;Goserelin;Desogestrel
2 High Intensity Focused Ultrasound Ablation Virus Myomectomy to Treat Uterine Fibroids Unknown status NCT01239641 Phase 4
3 Endometrial Preparation Before Operative Hysteroscopy in Premenopausal Women Unknown status NCT02440750 Phase 4 Dienogest;Ulipristal acetate
4 Ambulatory Oxygen in Fibrotic Lung Disease (FLD) (AmbOx) Unknown status NCT02286063 Phase 4 Ambulatory Oxygen
5 Seprafilm Slurry in the Prevention of Uterine Scarring in Patients Undergoing Hysteroscopic Myomectomy Unknown status NCT01632202 Phase 4
6 Fibroids in Women of Reproductive Age and Women Pregnancy Completed NCT02620345 Phase 4 Dydrogesterone M ( case 1 );Dydrogesterone M ( case 2 )
7 Novel MRI Strategies as a Non-invasive Biomarker in Women With Uterine Fibroids Completed NCT00746031 Phase 4 GnRH analogue (Zoladex);GnRH antagonist-Cetrorelix
8 A Prospective Study Comparing Contour SE™ Microspheres to Embosphere® Microspheres for Treating Symptomatic Uterine Fibroids With Uterine Fibroid Embolization (UFE) Completed NCT00628901 Phase 4
9 The FIRSTT: Comparing MRgFUS(MR-guided Focused Ultrasound) Versus UAE (Uterine Artery Embolization)for Uterine Fibroids. Completed NCT00995878 Phase 4
10 MR Guided Focused Ultrasound Surgery in the Treatment of Uterine Fibroids Completed NCT00166270 Phase 4
11 Intra-arterial Lidocaine for Pain Control Post Uterine Fibroid Embolization Completed NCT02293447 Phase 4 Lidocaine per-embolization;Lidocaine post-embolization
12 Safety Study of ExAblate for the Treatment of Uterine Fibroids Completed NCT01142791 Phase 4
13 Efficacy Study of Magnetic Resonance (MR) Guided Focused Ultrasound in the Treatment of Large Fibroids Completed NCT00159328 Phase 4
14 Safety Trial of Magnetic Resonance (MR) Guided Focused Ultrasound Surgery (FUS) in Women With Uterine Fibroids Wishing to Pursue Pregnancy in the Future Completed NCT00180739 Phase 4
15 Effectiveness of IV Acetaminophen and IV Ibuprofen in Reducing Post Procedural Pain in the UFE Procedure Completed NCT02227316 Phase 4 IV Ibuprofen;IV Acetaminophen;IV Placebo
16 Randomized Controlled Trial (RCT)Comparing GYNAECARE MORCELLEX Versus ROTOCUT GI Tissue Morcellators Completed NCT00743080 Phase 4
17 Efficacity Assessment of PREVADH® in Adhesion Prevention in Gynaecologic Surgery Completed NCT01388907 Phase 4
18 Vasopressin Administration During Laparoscopic Myomectomy: a Randomized Controlled Trial Completed NCT01393704 Phase 4 Vasopressin
19 Intravenous or Intra-abdominal Local Anesthetics for Postoperative Pain Management. Completed NCT01492179 Phase 4 Normal saline;Intravenous Lidocaine;Intra-abdominal Lidocaine
20 Comparing Two Types of Sedation to Gynaecological Patients Completed NCT01412632 Phase 4 Remifentanil, propofol and citanest
21 Single Versus Double Dose Intra-vaginal Prostaglandin E2 "Misoprostol" Prior Abdominal Myomectomy Completed NCT02154932 Phase 4 2 doses 400 microgram misoprostol;single dose misoprostol
22 Impact of Hot Flashes on Sleep and Mood Disturbance Completed NCT01116401 Phase 4 leuprolide
23 Ulipristal Acetate for the Preoperative Management of Hypoechoic Cellular Leiomyomas Recruiting NCT02361905 Phase 4 ulipristal acetate;Leuprolide acetate
24 Ulipristal Acetate Versus GnRH Analogue Treatment Before Hysteroscopic Resection of Uterine Leiomyoma Recruiting NCT02361879 Phase 4 ulipristal acetate;Leuprolide acetate
25 Ulipristal Acetate Versus GnRH Analogue and Myometrial Preservation Recruiting NCT02357563 Phase 4 ulipristal acetate;Leuprolide acetate
26 A Study on the Mifepristone Tablets in the Treatment of Symptomatic Uterine Fibroids With Safety and Efficacy Recruiting NCT03210324 Phase 4 Mifepristone tablets
27 Misoprostol for Reduction of Blood Loss During Fibroid Surgery Recruiting NCT02209545 Phase 4 Misoprostol;Placebo
28 Treatment of Heavy Menstrual Bleeding in Women With Uterine Fibroids Recruiting NCT03317795 Phase 4 Levonorgestrel IUS;Tranexamic Acid
29 Ulipristal Use in Chinese Population Recruiting NCT02825719 Phase 4 Ulipristal acetate;Ferrous sulphate;Tranexamic Acid
30 Aromatase Plus GnRH Analogue Versus Ulippristal Acetate in Uterine Fibroids Recruiting NCT03421639 Phase 4 Ulipristal acetate;Aromatase inhibitor plus GnRH analog
31 Ulipristal vs. GnRHa Prior to Laparoscopic Myomectomy Recruiting NCT02288130 Phase 4 GnRHa;Ulipristal
32 The Effect of Ulipristal Acetate (UPA) on Women Ovarian Reserve Recruiting NCT02361892 Phase 4 ulipristal acetate
33 Deep Versus Moderate Neuromuscular Blockade During Laparoscopic Surgery Recruiting NCT02812186 Phase 4 Rocuronium
34 Pilot of Letrozole for Uterine Myomas Active, not recruiting NCT02470741 Phase 4 Letrozole
35 IVF Outcome Following Treatment With Ulipristal Acetate for Myomatous Uterus After at Least One IVF Failure Not yet recruiting NCT02601196 Phase 4 Ulipristal acetate
36 ExAblate Treatment of Uterine Fibroids for Fertility Enhancement Terminated NCT00730886 Phase 4
37 Study to Evaluate the Safety and Effectiveness of MRgFUS Compared With Myomectomy for the Treatment of Uterine Fibroids Terminated NCT01328067 Phase 4
38 Uterine Fibroid Pregnancy Registry Terminated NCT00232713 Phase 4
39 Preemptive Analgesia Following Uterine Artery Embolization Terminated NCT01555073 Phase 4 pregabalin/celecoxib;pregabalin/placebo;celecoxib/placebo;Placebo group
40 Peritoneal Cavity Conditioning Decreases Pain, Inflammation and Adhesions Terminated NCT01344486 Phase 4
41 Effect of Ulipristal Acetate on Bleeding Patterns and Dysmenorrhea in Women With Adenomyosis Withdrawn NCT03325868 Phase 4 Ulipristal Acetate
42 Influence of Aromatase Inhibitors and GnRH Analogs to Treat Uterine Leiomyoma by Vaginal Hysterectomy Unknown status NCT01280045 Phase 3
43 Study of Tumor-shrinking Decoction (TSD) to Treat Symptomatic Uterine Fibroids Unknown status NCT02189083 Phase 3 TSD
44 The Use of Doppler to Diagnose Myometrial Masses Unknown status NCT01833871 Phase 2, Phase 3
45 Single Incision Laparoscopic Surgery (SILS) Versus Conventional Laparoscopic Hysterectomy Unknown status NCT01483417 Phase 3
46 Single-port Access Laparoscopic-assisted Vaginal Hysterectomy Unknown status NCT01048931 Phase 3
47 Long Term Prevention of Nausea and Vomiting in Gynecologic Laparoscopy Unknown status NCT02011659 Phase 3 Ramosetron
48 Understanding Experimentally Induced Hot Flushes Unknown status NCT00455689 Phase 2, Phase 3 Leuprolide acetate (Lupron)
49 Therapeutic MRI Guided High Intensity Focused Ultrasound Ablation of Uterine Fibroids Completed NCT01141062 Phase 3
50 Therapeutic MRI-HIFU Ablation of Uterine Fibroids in a 3T MRI Scanner Completed NCT01064960 Phase 3

Search NIH Clinical Center for Leiomyoma

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: leiomyoma

Genetic Tests for Leiomyoma

Anatomical Context for Leiomyoma

MalaCards organs/tissues related to Leiomyoma:

38
Uterus, Smooth Muscle, Prostate, Breast, Lung, Endothelial, Bone

Publications for Leiomyoma

Articles related to Leiomyoma:

(show top 50) (show all 1676)
# Title Authors Year
1
The AKT/BCL-2 axis mediates survival of uterine leiomyoma in a novel 3D spheroid model. ( 29381777 )
2018
2
Placenta increta after high intensity-focused ultrasound for the treatment of a uterine leiomyoma. ( 29410151 )
2018
3
Rare symptomatic bladder leiomyoma: case report and literature review. ( 29436249 )
2018
4
Peritoneal sarcomatosis 5 years after laparoscopic morcellation of uterine leiomyoma. ( 29338993 )
2018
5
Utility of Clinical Parameters and Multiparametric MRI as Predictive Factors for Differentiating Uterine Sarcoma From Atypical Leiomyoma. ( 29422425 )
2018
6
What MRI features suspect malignant pure mesenchymal uterine tumors rather than uterine leiomyoma with cystic degeneration? ( 29400019 )
2018
7
Whole exome sequencing of benign pulmonary metastasizing leiomyoma reveals mutation in the BMP8B gene. ( 29386003 )
2018
8
Overexpression of the 14-3-3I^ protein in uterine leiomyoma cells results in growth retardation and increased apoptosis. ( 29382566 )
2018
9
Karakousis's abdominoinguinal approach for the treatment of a primary retroperitoneal parasitic leiomyoma with inguinal extension. A case report. ( 29373207 )
2018
10
Increased Risk of Venous Thromboembolism in Women with Uterine Leiomyoma: A Nationwide, Population-Based Case-Control Study. ( 29375226 )
2018
11
Mesenteric Leiomyoma in Infancy. ( 29386769 )
2018
12
A Huge Prolapsed Pedunculated Necrotizing Submucosal Leiomyoma. ( 29409934 )
2018
13
Association of Uterine Leiomyomas With Central Centrifugal Cicatricial Alopecia. ( 29282458 )
2018
14
A Unique Finding of Small Intestinal Leiomyoma. ( 29410052 )
2018
15
Association between fok1 polymorphism of vitamin D receptor gene with uterine leiomyoma in Turkish populations. ( 29391329 )
2018
16
Irrigation after Laparoscopic Power Morcellation and the Dispersal of Leiomyoma Cells: a Pilot Study. ( 29408695 )
2018
17
Clinical Predictors of Successful Vaginal Myomectomy for Prolapsed Pedunculated Uterine Leiomyoma. ( 29449196 )
2018
18
Painless vascular leiomyoma found after incision of the vaginal wall: A case report. ( 29359115 )
2018
19
Leiomyoma on gingiva with osseous involvement: An unusual presentation. ( 29386803 )
2017
20
Metastases of breast cancer to a uterine leiomyoma. ( 28925535 )
2017
21
Transurethral Resection of a Large Urinary Bladder Leiomyoma: A Rare Case Report. ( 28670675 )
2017
22
Differential DNA Hydroxymethylation in Human Uterine Leiomyoma Cells Depending on the Phase of Menstrual Cycle and Presence of MED12 Gene Mutations. ( 28944423 )
2017
23
Association between urinary phthalate metabolites and risk of breast cancer and uterine leiomyoma. ( 28951174 )
2017
24
ERI+36, a variant of estrogen receptor I+, is predominantly localized in mitochondria of human uterine smooth muscle and leiomyoma cells. ( 29020039 )
2017
25
Treatment of cutaneous leiomyomas with 5% lidocaine patches in a patient with hereditary leiomyomatosis and renal cell cancer (Reed syndrome). ( 28884140 )
2017
26
Anterior abdominal wall parasitic leiomyoma: case report. ( 28925767 )
2017
27
Massively parallel sequencing and genome-wide copy number analysis revealed a clonal relationship in benign metastasizing leiomyoma. ( 28533481 )
2017
28
Replication of GWAS loci revealed the moderate effect of TNRC6B locus on susceptibility of Saudi women to develop uterine leiomyomas. ( 27987337 )
2017
29
Is Immunohistochemical Screening of Cutaneous Leiomyomas for the Early Detection of Hereditary Leiomyomatosis and Renal Cell Carcinoma Syndrome Justified? ( 29053494 )
2017
30
Metastatic Epicardial Leiomyoma with uncertain malignant potential. ( 29423163 )
2017
31
Pulmonary benign metastasizing leiomyoma presented as acute respiratory distress. ( 28116091 )
2017
32
Intragastric Single-Incision Laparoscopic Surgery for Gastric Leiomyoma: A Stepwise Approach. ( 28466402 )
2017
33
Bladder Leiomyoma. ( 28406781 )
2017
34
Benign metastasizing leiomyoma presenting as multiple cystic pulmonary nodules: a case report. ( 28899426 )
2017
35
Versican Proteolysis by ADAMTS Proteases and Its Influence on Sex Steroid Receptor Expression in Uterine Leiomyoma. ( 28323982 )
2017
36
Bladder leiomyoma. ( 28794597 )
2017
37
Inguinal canal spermatic cord leiomyoma presenting as an incarcerated inguinal hernia. ( 28821481 )
2017
38
Leiomyoma of the urinary bladder. ( 28924293 )
2017
39
The effect of uterine leiomyoma on the risk of malpresentation and cesarean: a meta-analysis. ( 28027686 )
2017
40
Metastasising leiomyoma of the uterus with pulmonary involvement - case report. ( 28871589 )
2017
41
Endoscopic Laser Management of a Leiomyoma of the Left Main Stem Bronchus. ( 27984395 )
2017
42
Benign metastasizing leiomyoma and 18-FDG-PET/CT: A case report and literature review. ( 28927125 )
2017
43
A Role for Progesterone-Regulated sFRP4 Expression in Uterine Leiomyomas. ( 28637297 )
2017
44
Total Laparoscopic Treatment With Cystotomy for Intramural Bladder Leiomyoma. ( 28373126 )
2017
45
Monitoring Leiomyoma Response to Uterine Artery Embolization Using Diffusion and Perfusion Indices from Diffusion-Weighted Imaging. ( 28929111 )
2017
46
Surgical management of a large neurilemmoma-like leiomyoma of the uterine cervix mimicking a retroperitoneal tumor. ( 28702500 )
2017
47
Aspirin inhibits the proliferation of human uterine leiomyoma cells by downregulation of Ka89Rasa89p110I+ interaction. ( 28849118 )
2017
48
A Case of Simultaneous Benign Metastasizing Leiomyomas and Disseminated Peritoneal Leiomyomatosis Following Endoscopic Power Morcellation for Uterine Disease. ( 27748666 )
2017
49
Paracrine Pathways in Uterine Leiomyoma Stem Cells Involve Insulinlike Growth Factor 2 and Insulin Receptor A. ( 28324020 )
2017
50
Recurrent Pneumothoraces in a Patient With Pulmonary Benign Metastasizing Leiomyoma. ( 29026364 )
2017

Variations for Leiomyoma

Expression for Leiomyoma

Search GEO for disease gene expression data for Leiomyoma.

Pathways for Leiomyoma

GO Terms for Leiomyoma

Cellular components related to Leiomyoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 CD34 COL4A5 COL4A6 ESR2 GNRH1 IGF2
2 collagen type IV trimer GO:0005587 8.62 COL4A5 COL4A6

Biological processes related to Leiomyoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of DNA binding transcription factor activity GO:0051091 9.58 ESR1 ESR2 HMGA2
2 androgen metabolic process GO:0008209 9.37 CYP19A1 ESR1
3 steroid hormone mediated signaling pathway GO:0043401 9.33 ESR1 ESR2 PGR
4 uterus development GO:0060065 9.32 CYP19A1 ESR1
5 collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 9.26 COL4A5 COL4A6
6 paracrine signaling GO:0038001 8.96 CD34 PGR
7 mammary gland development GO:0030879 8.8 CYP19A1 PGR TGFB3

Molecular functions related to Leiomyoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATPase binding GO:0051117 9.58 ESR1 PGR S100A1
2 steroid hormone receptor activity GO:0003707 9.54 ESR1 ESR2 PGR
3 nuclear receptor activity GO:0004879 9.43 ESR1 ESR2 PGR
4 estrogen receptor activity GO:0030284 9.32 ESR1 ESR2
5 estrogen response element binding GO:0034056 9.16 ESR1 ESR2
6 steroid binding GO:0005496 9.13 ESR1 ESR2 PGR
7 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding GO:0038052 8.62 ESR1 ESR2

Sources for Leiomyoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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