Aliases & Classifications for Leiomyoma

MalaCards integrated aliases for Leiomyoma:

Name: Leiomyoma 12 52 42 14
Leiomyomatous Neoplasm 12
Leiomyomatous Tumor 12
Uterine Fibroids 69
Fibroid Tumor 69

Classifications:



External Ids:

Disease Ontology 12 DOID:127
MeSH 42 D007889
NCIt 47 C3157
ICD10 33 D25.9
UMLS 69 C0023267

Summaries for Leiomyoma

Disease Ontology : 12 A cell type benign neoplasm that is a benign tumor of smooth muscle cells.

MalaCards based summary : Leiomyoma, also known as leiomyomatous neoplasm, is related to gallbladder leiomyoma and leiomyoma cutis, and has symptoms including pelvic pain An important gene associated with Leiomyoma is HMGA2 (High Mobility Group AT-Hook 2), and among its related pathways/superpathways are AGE-RAGE signaling pathway in diabetic complications and Amoebiasis. The drugs Desogestrel and Dienogest have been mentioned in the context of this disorder. Affiliated tissues include uterus, smooth muscle and prostate, and related phenotypes are Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) and homeostasis/metabolism

Wikipedia : 72 A leiomyoma, also known as fibroids, is a benign smooth muscle tumor that very rarely becomes cancer... more...

Related Diseases for Leiomyoma

Diseases related to Leiomyoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 364)
id Related Disease Score Top Affiliating Genes
1 gallbladder leiomyoma 34.2 ESR1 PGR
2 leiomyoma cutis 34.0 ACTC1 PGR
3 dartoic leiomyoma 33.9 ESR1 PGR
4 uterine corpus apoplectic leiomyoma 32.6 ESR1 MME PGR
5 large bowel leiomyoma 31.9 COL4A5 COL4A6 ESR1 FH GNRH1 PGR
6 gastrointestinal stromal tumor 31.1 ACTC1 CD34 DES IGF2 MKI67 S100A1
7 myoma 31.0 ACTC1 DES
8 thyroiditis 30.6 CD34 PGR
9 cutaneous leiomyosarcoma 30.4 ACTC1 PGR
10 transitional cell carcinoma 30.3 DES HMGA2
11 myxoid leiomyosarcoma 30.0 ACTC1 DES
12 small cell neuroendocrine carcinoma 29.4 ACTC1 CD34 DES S100A1
13 histiocytoma 28.4 ACTC1 CYP19A1 DES ESR1 MME PGR
14 benign metastasizing leiomyoma 12.1
15 bizarre leiomyoma 11.9
16 gastric leiomyoma 11.9
17 uterine fibroid 11.8
18 leiomyomatosis and renal cell cancer 11.8
19 bladder leiomyoma 11.8
20 prostate leiomyoma 11.8
21 multiple cutaneous and uterine leiomyomas 11.8
22 liver leiomyoma 11.8
23 small intestine leiomyoma 11.8
24 lung leiomyoma 11.8
25 uterus interstitial leiomyoma 11.8
26 vulvar leiomyoma 11.8
27 deep leiomyoma 11.8
28 colon leiomyoma 11.8
29 endobronchial leiomyoma 11.7
30 orbital leiomyoma 11.7
31 breast leiomyoma 11.7
32 esophagus leiomyoma 11.7
33 leiomyoma, uterine, somatic 11.7
34 ureter leiomyoma 11.7
35 trachea leiomyoma 11.7
36 extrahepatic bile duct leiomyoma 11.6
37 central nervous system leiomyoma 11.6
38 anus leiomyoma 11.6
39 pericardium leiomyoma 11.6
40 urethra leiomyoma 11.6
41 vagina leiomyoma 11.6
42 appendix leiomyoma 11.6
43 uterine corpus bizarre leiomyoma 11.6
44 mediastinum leiomyoma 11.6
45 rectum leiomyoma 11.6
46 uterine corpus cellular leiomyoma 11.6
47 leiomyoma of vulva and esophagus 11.6
48 uterine corpus epithelioid leiomyoma 11.6
49 larynx leiomyoma 11.6
50 uterine corpus dissecting leiomyoma 11.6

Graphical network of the top 20 diseases related to Leiomyoma:



Diseases related to Leiomyoma

Symptoms & Phenotypes for Leiomyoma

UMLS symptoms related to Leiomyoma:


pelvic pain

GenomeRNAi Phenotypes related to Leiomyoma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 9.1 ESR1 ESR2 FH IGF2 MKI67 RAD51B

MGI Mouse Phenotypes related to Leiomyoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.21 TGFB3 ACTC1 CD34 COL4A5 CYP19A1 DES
2 cellular MP:0005384 10.17 IGF2 PGR S100A1 TGFB3 ACTC1 CD34
3 cardiovascular system MP:0005385 10.16 ACTC1 COL4A5 CYP19A1 DES ESR1 ESR2
4 immune system MP:0005387 10.06 CD34 COL4A5 CYP19A1 ESR1 ESR2 GNRH1
5 digestive/alimentary MP:0005381 9.95 CYP19A1 ESR1 ESR2 GNRH1 IGF2 IL17B
6 integument MP:0010771 9.91 CD34 CYP19A1 DPT ESR1 ESR2 GNRH1
7 muscle MP:0005369 9.76 ACTC1 CYP19A1 DES ESR1 ESR2 IGF2
8 normal MP:0002873 9.65 ACTC1 COL4A6 CYP19A1 ESR1 ESR2 GNRH1
9 renal/urinary system MP:0005367 9.17 COL4A5 CYP19A1 ESR1 ESR2 FH GNRH1

Drugs & Therapeutics for Leiomyoma

Drugs for Leiomyoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 253)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Desogestrel Approved Phase 4 54024-22-5 40973
2
Dienogest Approved Phase 4 65928-58-7
3
Goserelin Approved Phase 4,Phase 3,Phase 2 65807-02-5 47725 5311128
4
Nandrolone Approved, Experimental, Illicit Phase 4 434-22-0, 62-90-8 9904 229455
5
Nandrolone decanoate Approved, Illicit Phase 4 360-70-3 9677
6
Dimenhydrinate Approved Phase 4 523-87-5 441281
7
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741 24759
8
Calcium Carbonate Approved Phase 4,Phase 3 471-34-1
9
Leuprolide Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 53714-56-0 3911 657181
10
Hydroxocobalamin Approved Phase 4 13422-51-0 11953898 5460373 44475014
11
Zinc Approved Phase 4 7440-66-6 32051 23994
12
Zinc oxide Approved Phase 4 1314-13-2
13
Cetrorelix Approved, Investigational Phase 4 120287-85-6 16129715 25074887
14
Ethanol Approved Phase 4 64-17-5 702
15
Lidocaine Approved, Vet_approved Phase 4,Phase 2 137-58-6 3676
16
Acetaminophen Approved Phase 4 103-90-2 1983
17
Ibuprofen Approved Phase 4 15687-27-1 3672
18
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
19
Morphine Approved, Investigational Phase 4 57-27-2 5288826
20
Prilocaine Approved Phase 4 721-50-6 4906
21
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
22
Remifentanil Approved Phase 4 132875-61-7 60815
23
Dinoprostone Approved Phase 4 363-24-6 5280360
24
Misoprostol Approved Phase 4,Phase 3,Phase 2 59122-46-2 5282381
25
Mifepristone Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 84371-65-3 55245
26
Progesterone Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 57-83-0 5994
27
Benzocaine Approved Phase 4 1994-09-7, 94-09-7 2337
28
Letrozole Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 112809-51-5 3902
29
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
30
Tranexamic Acid Approved Phase 4,Phase 3,Phase 1 1197-18-8 5526
31
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
32
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
33
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
34
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
35
Vitamin C Approved, Nutraceutical Phase 4,Phase 3 50-81-7 5785 54670067
36
Glycine Approved, Nutraceutical, Vet_approved Phase 4 56-40-6 750
37
B-Carotene Approved, Nutraceutical Phase 4 7235-40-7 5280489
38
Cholecalciferol Approved, Nutraceutical Phase 4 67-97-0 6221 10883523 5280795
39
Cyanocobalamin Approved, Nutraceutical Phase 4 68-19-9 44176380
40
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
41
leucovorin Approved, Nutraceutical Phase 4 58-05-9 143 6006
42
Niacin Approved, Investigational, Nutraceutical Phase 4 59-67-6 938
43
Nicotinamide Approved, Nutraceutical Phase 4 98-92-0 936
44
Pyridoxal Approved, Nutraceutical Phase 4 66-72-8 1050
45
Pyridoxine Approved, Nutraceutical, Vet_approved Phase 4 65-23-6 1054
46
Riboflavin Approved, Nutraceutical, Vet_approved Phase 4 83-88-5 493570
47
Thiamine Approved, Nutraceutical, Vet_approved Phase 4 59-43-8 1130
48 Tocopherol Approved, Nutraceutical Phase 4
49
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
50 tannic acid Approved, Nutraceutical Phase 4

Interventional clinical trials:

(show top 50) (show all 313)

id Name Status NCT ID Phase Drugs
1 Study of the Efficacy of Dienogest in the Treatment of Uterine Leiomyomas When Compared to Desogestrel and Goserelin Unknown status NCT01738724 Phase 4 Dienogest;Goserelin;Desogestrel
2 High Intensity Focused Ultrasound Ablation Virus Myomectomy to Treat Uterine Fibroids Unknown status NCT01239641 Phase 4
3 Ambulatory Oxygen in Fibrotic Lung Disease (FLD) (AmbOx) Unknown status NCT02286063 Phase 4 Ambulatory Oxygen
4 Seprafilm Slurry in the Prevention of Uterine Scarring in Patients Undergoing Hysteroscopic Myomectomy Unknown status NCT01632202 Phase 4
5 Fibroids in Women of Reproductive Age and Women Pregnancy Completed NCT02620345 Phase 4 Dydrogesterone M ( case 1 );Dydrogesterone M ( case 2 )
6 Novel MRI Strategies as a Non-invasive Biomarker in Women With Uterine Fibroids Completed NCT00746031 Phase 4 GnRH analogue (Zoladex);GnRH antagonist-Cetrorelix
7 A Prospective Study Comparing Contour SE™ Microspheres to Embosphere® Microspheres for Treating Symptomatic Uterine Fibroids With Uterine Fibroid Embolization (UFE) Completed NCT00628901 Phase 4
8 MR Guided Focused Ultrasound Surgery in the Treatment of Uterine Fibroids Completed NCT00166270 Phase 4
9 Efficacy Study of Magnetic Resonance (MR) Guided Focused Ultrasound in the Treatment of Large Fibroids Completed NCT00159328 Phase 4
10 Safety Study of ExAblate for the Treatment of Uterine Fibroids Completed NCT01142791 Phase 4
11 Intra-arterial Lidocaine for Pain Control Post Uterine Fibroid Embolization Completed NCT02293447 Phase 4 Lidocaine per-embolization;Lidocaine post-embolization
12 Safety Trial of Magnetic Resonance (MR) Guided Focused Ultrasound Surgery (FUS) in Women With Uterine Fibroids Wishing to Pursue Pregnancy in the Future Completed NCT00180739 Phase 4
13 Effectiveness of IV Acetaminophen and IV Ibuprofen in Reducing Post Procedural Pain in the UFE Procedure Completed NCT02227316 Phase 4 IV Ibuprofen;IV Acetaminophen;IV Placebo
14 Randomized Controlled Trial (RCT)Comparing GYNAECARE MORCELLEX Versus ROTOCUT GI Tissue Morcellators Completed NCT00743080 Phase 4
15 Efficacity Assessment of PREVADH® in Adhesion Prevention in Gynaecologic Surgery Completed NCT01388907 Phase 4
16 Vasopressin Administration During Laparoscopic Myomectomy: a Randomized Controlled Trial Completed NCT01393704 Phase 4 Vasopressin
17 Intravenous or Intra-abdominal Local Anesthetics for Postoperative Pain Management. Completed NCT01492179 Phase 4 Normal saline;Intravenous Lidocaine;Intra-abdominal Lidocaine
18 Comparing Two Types of Sedation to Gynaecological Patients Completed NCT01412632 Phase 4 Remifentanil, propofol and citanest
19 Single Versus Double Dose Intra-vaginal Prostaglandin E2 "Misoprostol" Prior Abdominal Myomectomy Completed NCT02154932 Phase 4 2 doses 400 microgram misoprostol;single dose misoprostol
20 Ulipristal Acetate for the Preoperative Management of Hypoechoic Cellular Leiomyomas Recruiting NCT02361905 Phase 4 ulipristal acetate;Leuprolide acetate
21 Ulipristal Acetate Versus GnRH Analogue Treatment Before Hysteroscopic Resection of Uterine Leiomyoma Recruiting NCT02361879 Phase 4 ulipristal acetate;Leuprolide acetate
22 Ulipristal Acetate Versus GnRH Analogue and Myometrial Preservation Recruiting NCT02357563 Phase 4 ulipristal acetate;Leuprolide acetate
23 Misoprostol for Reduction of Blood Loss During Fibroid Surgery Recruiting NCT02209545 Phase 4 Misoprostol;Placebo
24 A Study on the Mifepristone Tablets in the Treatment of Symptomatic Uterine Fibroids With Safety and Efficacy Recruiting NCT03210324 Phase 4 Mifepristone tablets
25 Ulipristal Use in Chinese Population Recruiting NCT02825719 Phase 4 Ulipristal acetate;Ferrous sulphate;Tranexamic Acid
26 Ulipristal vs. GnRHa Prior to Laparoscopic Myomectomy Recruiting NCT02288130 Phase 4 GnRHa;Ulipristal
27 The Effect of Ulipristal Acetate (UPA) on Women Ovarian Reserve Recruiting NCT02361892 Phase 4 ulipristal acetate
28 Surgical Success After Laparoscopic vs Abdominal Hysterectomy Recruiting NCT01793584 Phase 4
29 Deep Versus Moderate Neuromuscular Blockade During Laparoscopic Surgery Recruiting NCT02812186 Phase 4 Rocuronium
30 Uterine Leiomyoma Treatment With Radiofrequency Ablation Active, not recruiting NCT01840124 Phase 4
31 Pilot of Letrozole for Uterine Myomas Active, not recruiting NCT02470741 Phase 4 Letrozole
32 The FIRSTT: Comparing MRgFUS(MR-guided Focused Ultrasound) Versus UAE (Uterine Artery Embolization)for Uterine Fibroids. Active, not recruiting NCT00995878 Phase 4
33 Feasibility and Yield of a New 20 G ProCore Needle With Coiled Sheath in the Gastrointestinal Subepithelial Tumors Enrolling by invitation NCT02884154 Phase 4
34 IVF Outcome Following Treatment With Ulipristal Acetate for Myomatous Uterus After at Least One IVF Failure Not yet recruiting NCT02601196 Phase 4 Ulipristal acetate
35 Endometrial Preparation Before Operative Hysteroscopy in Premenopausal Women Not yet recruiting NCT02440750 Phase 4 Dienogest;Ulipristal acetate
36 ExAblate Treatment of Uterine Fibroids for Fertility Enhancement Terminated NCT00730886 Phase 4
37 Study to Evaluate the Safety and Effectiveness of MRgFUS Compared With Myomectomy for the Treatment of Uterine Fibroids Terminated NCT01328067 Phase 4
38 Uterine Fibroid Pregnancy Registry Terminated NCT00232713 Phase 4
39 Preemptive Analgesia Following Uterine Artery Embolization Terminated NCT01555073 Phase 4 pregabalin/celecoxib;pregabalin/placebo;celecoxib/placebo;Placebo group
40 Peritoneal Cavity Conditioning Decreases Pain, Inflammation and Adhesions Terminated NCT01344486 Phase 4
41 Influence of Aromatase Inhibitors and GnRH Analogs to Treat Uterine Leiomyoma by Vaginal Hysterectomy Unknown status NCT01280045 Phase 3
42 Study of Tumor-shrinking Decoction (TSD) to Treat Symptomatic Uterine Fibroids Unknown status NCT02189083 Phase 3 TSD
43 Study on the Effect of Intravenous Ascorbic Acid on Intraoperative Blood Loss in Women With Uterine Myoma Unknown status NCT01715597 Phase 3 ascorbic acid
44 The Use of Doppler to Diagnose Myometrial Masses Unknown status NCT01833871 Phase 2, Phase 3
45 Single Incision Laparoscopic Surgery (SILS) Versus Conventional Laparoscopic Hysterectomy Unknown status NCT01483417 Phase 3
46 Single-port Access Laparoscopic-assisted Vaginal Hysterectomy Unknown status NCT01048931 Phase 3
47 Long Term Prevention of Nausea and Vomiting in Gynecologic Laparoscopy Unknown status NCT02011659 Phase 3 Ramosetron
48 Understanding Experimentally Induced Hot Flushes Unknown status NCT00455689 Phase 2, Phase 3 Leuprolide acetate (Lupron)
49 Therapeutic MRI Guided High Intensity Focused Ultrasound Ablation of Uterine Fibroids Completed NCT01141062 Phase 3
50 Therapeutic MRI-HIFU Ablation of Uterine Fibroids in a 3T MRI Scanner Completed NCT01064960 Phase 3

Search NIH Clinical Center for Leiomyoma

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: leiomyoma

Genetic Tests for Leiomyoma

Anatomical Context for Leiomyoma

MalaCards organs/tissues related to Leiomyoma:

39
Uterus, Smooth Muscle, Prostate, Breast, Lung, Bone, Endothelial

Publications for Leiomyoma

Articles related to Leiomyoma:

(show top 50) (show all 1640)
id Title Authors Year
1
The effect of uterine leiomyoma on the risk of malpresentation and cesarean: a meta-analysis. ( 28027686 )
2017
2
Association between urinary phthalate metabolites and risk of breast cancer and uterine leiomyoma. ( 28951174 )
2017
3
Surgical management of a large neurilemmoma-like leiomyoma of the uterine cervix mimicking a retroperitoneal tumor. ( 28702500 )
2017
4
Benign metastasizing leiomyoma and 18-FDG-PET/CT: A case report and literature review. ( 28927125 )
2017
5
Giant leiomyoma with extensive myxoid degeneration in Mayer-Rokitansky-KA1ster-Hauser syndrome. ( 28369817 )
2017
6
Massively parallel sequencing and genome-wide copy number analysis revealed a clonal relationship in benign metastasizing leiomyoma. ( 28533481 )
2017
7
Highly heterogeneous genomic landscape of uterine leiomyomas byA whole exome sequencing and genome-wide arrays. ( 27889101 )
2017
8
Intragastric Single-Incision Laparoscopic Surgery for Gastric Leiomyoma: A Stepwise Approach. ( 28466402 )
2017
9
Cystoscopic Evaluation of Bladder Leiomyoma. ( 28161381 )
2017
10
A Large Posteriorly Located Prostatic Mass Lesion Challenging the Robotic Surgeon: Prostate Leiomyoma. ( 28560353 )
2017
11
A case of otitis media with effusion due to leiomyoma of the Eustachian tube. ( 28818348 )
2017
12
A large uterine leiomyoma leading to non-puerperal uterine inversion: A case report. ( 28280801 )
2017
13
Benign metastasizing leiomyoma presenting as multiple cystic pulmonary nodules: a case report. ( 28899426 )
2017
14
Non-neural granular cell tumor of the uterine corpus mimicking uterine leiomyoma: A case report. ( 28781812 )
2017
15
A Case of Simultaneous Benign Metastasizing Leiomyomas and Disseminated Peritoneal Leiomyomatosis Following Endoscopic Power Morcellation for Uterine Disease. ( 27748666 )
2017
16
Review of the pathophysiology, diagnosis, and therapy of vulvar leiomyoma, a rare gynecological tumor. ( 28875758 )
2017
17
Metastasising leiomyoma of the uterus with pulmonary involvement - case report. ( 28871589 )
2017
18
Expression Profiling of lncRNAs, miRNAs, and mRNAs and Their Differential Expression in Leiomyoma Using Next-Generation RNA Sequencing. ( 28587571 )
2017
19
Primary Cardiac Leiomyoma Causing Right Ventricular Obstruction and Tricuspid Regurgitation. ( 28838514 )
2017
20
Benign metastasizing leiomyoma: A review of current literature in respect to the time and type of previous gynecological surgery. ( 28426767 )
2017
21
Transurethral Resection of a Large Urinary Bladder Leiomyoma: A Rare Case Report. ( 28670675 )
2017
22
Malignant Transformation of Pulmonary Benign Metastasizing Leiomyoma. ( 28180107 )
2017
23
Differential Diagnosis between Bartholin Cyst and Vulvar Leiomyoma: Case Report. ( 28783860 )
2017
24
Intraparenchymal Leiomyoma of the Breast: A Rare Location for an Infrequent Tumor. ( 28894856 )
2017
25
Metastases of breast cancer to a uterine leiomyoma. ( 28925535 )
2017
26
Pulmonary benign metastasizing leiomyoma presented as acute respiratory distress. ( 28116091 )
2017
27
Total Laparoscopic Treatment With Cystotomy for Intramural Bladder Leiomyoma. ( 28373126 )
2017
28
Bladder Leiomyoma. ( 28406781 )
2017
29
Human Chorionic Gonadotrophin as a Possible Mediator of Leiomyoma Growth during Pregnancy: Molecular Mechanisms. ( 28930160 )
2017
30
Submucosal tunneling endoscopic resection of a gigantic esophageal leiomyoma. ( 28946172 )
2017
31
Symplastic epididymal leiomyoma with bizarre cytology. ( 28868647 )
2017
32
Endoscopic Laser Management of a Leiomyoma of the Left Main Stem Bronchus. ( 27984395 )
2017
33
Differential DNA Hydroxymethylation in Human Uterine Leiomyoma Cells Depending on the Phase of Menstrual Cycle and Presence of MED12 Gene Mutations. ( 28944423 )
2017
34
Monitoring Leiomyoma Response to Uterine Artery Embolization Using Diffusion and Perfusion Indices from Diffusion-Weighted Imaging. ( 28929111 )
2017
35
Bladder leiomyoma. ( 28794597 )
2017
36
Fumarate Hydratase Mutations and Alterations in Leiomyoma With Bizarre Nuclei. ( 28863073 )
2017
37
A Case of Pedunculated Esophageal Leiomyoma Successfully Treated by Endoscopic Mucosal Resection. ( 28871579 )
2017
38
Novel Fumarate Hydratase Mutation in Siblings With Early Onset Uterine Leiomyomas and Hereditary Leiomyomatosis and Renal Cell Cancer Syndrome. ( 28700432 )
2017
39
Leiomyoma of the urinary bladder. ( 28924293 )
2017
40
Catechol-O-methyltransferase Val158Met polymorphism is associated with increased risk of multiple uterine leiomyomas either positive or negative for MED12 exon 2 mutations. ( 27491313 )
2017
41
Immunohistochemical Characterization of Fumarate Hydratase (FH) and Succinate Dehydrogenase (SDH) in Cutaneous Leiomyomas for Detection of Familial Cancer Syndromes. ( 28288038 )
2017
42
Aspirin inhibits the proliferation of human uterine leiomyoma cells by downregulation of Ka89Rasa89p110I+ interaction. ( 28849118 )
2017
43
Inguinal canal spermatic cord leiomyoma presenting as an incarcerated inguinal hernia. ( 28821481 )
2017
44
Treatment of cutaneous leiomyomas with 5% lidocaine patches in a patient with hereditary leiomyomatosis and renal cell cancer (Reed syndrome). ( 28884140 )
2017
45
Leiomyoma of the Palpebral Conjunctiva. ( 27993264 )
2017
46
Replication of GWAS loci revealed the moderate effect of TNRC6B locus on susceptibility of Saudi women to develop uterine leiomyomas. ( 27987337 )
2017
47
Anterior abdominal wall parasitic leiomyoma: case report. ( 28925767 )
2017
48
Endoscopic dissection of a symptomatic giant gastric leiomyoma arising from the muscularis propria. ( 28355652 )
2017
49
Efficacy of PET/CT to exclude leiomyoma in patients with lesions suspicious for uterine sarcoma on MRI. ( 28805609 )
2017
50
Leiomyoma of the Vulva. ( 27158878 )
2016

Variations for Leiomyoma

Expression for Leiomyoma

Search GEO for disease gene expression data for Leiomyoma.

Pathways for Leiomyoma

GO Terms for Leiomyoma

Cellular components related to Leiomyoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 CD34 COL4A5 COL4A6 ESR2 GNRH1 IGF2
2 collagen type IV trimer GO:0005587 8.62 COL4A5 COL4A6

Biological processes related to Leiomyoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 androgen metabolic process GO:0008209 9.37 CYP19A1 ESR1
2 steroid hormone mediated signaling pathway GO:0043401 9.33 ESR1 ESR2 PGR
3 uterus development GO:0060065 9.32 CYP19A1 ESR1
4 collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 9.26 COL4A5 COL4A6
5 paracrine signaling GO:0038001 8.96 CD34 PGR
6 mammary gland development GO:0030879 8.62 CYP19A1 TGFB3

Molecular functions related to Leiomyoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 ATPase binding GO:0051117 9.58 ESR1 PGR S100A1
2 steroid hormone receptor activity GO:0003707 9.54 ESR1 ESR2 PGR
3 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0004879 9.43 ESR1 ESR2 PGR
4 estrogen receptor activity GO:0030284 9.32 ESR1 ESR2
5 estrogen response element binding GO:0034056 9.16 ESR1 ESR2
6 steroid binding GO:0005496 9.13 ESR1 ESR2 PGR
7 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding GO:0038052 8.62 ESR1 ESR2

Sources for Leiomyoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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