Aliases & Classifications for Leiomyomatosis

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Aliases & Descriptions for Leiomyomatosis:

Name: Leiomyomatosis 10 47 12 36 65
 
Leiomyomatosis, No Icd-O Subtype 10

Classifications:



External Ids:

Disease Ontology10 DOID:5138
MeSH36 D018231
SNOMED-CT59 189789002, 75210008
NCIt42 C3748
UMLS65 C0206654

Summaries for Leiomyomatosis

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Wikipedia:68 A leiomyoma (plural leiomyomas or leiomyomata) (leio- + myo- + -oma, \"smooth-muscle tumor\") is a... more...

MalaCards based summary: Leiomyomatosis, also known as leiomyomatosis, no icd-o subtype, is related to leiomyomatosis and renal cell cancer and leiomyoma. An important gene associated with Leiomyomatosis is FH (Fumarate Hydratase), and among its related pathways are NCAM1 interactions and AGE-RAGE signaling pathway in diabetic complications. Affiliated tissues include uterus, breast and smooth muscle, and related mouse phenotypes are renal/urinary system and normal.

Related Diseases for Leiomyomatosis

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Diseases related to Leiomyomatosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 150)
idRelated DiseaseScoreTop Affiliating Genes
1leiomyomatosis and renal cell cancer33.7FH, LDHA, SDHB
2leiomyoma30.5ESR1, PGR
3intravenous leiomyomatosis12.3
4disseminated peritoneal leiomyomatosis12.3
5diffuse peritoneal leiomyomatosis12.1
6leiomyomatosis, esophageal and vulval, with nephropathy12.0
7uterus intravascular leiomyomatosis11.9
8uterine corpus leiomyomatosis11.9
9uterine corpus diffuse leiomyomatosis11.9
10leiomyomatosis of esophagus, cataract and hematuria11.8
11x-linked diffuse leiomyomatosis-alport syndrome11.8
12leiomyoma of vulva and esophagus11.0
13multiple cutaneous and uterine leiomyomas11.0
14alport syndrome10.8
15autosomal dominant striatal neurodegeneration10.7COL4A5, COL4A6
16ataxia with vitamin e deficiency10.5COL4A4, COL4A5
17hematuria, benign familial10.5COL4A4, COL4A5
18familial stomach cancer10.5FH, SDHB
19alport syndrome, autosomal recessive10.5COL4A4, COL4A5
20esophagitis10.5
21peritonitis10.5
22basilar migraine10.4COL4A4, COL4A5
23hypersensitivity vasculitis10.4COL4A4, COL4A5
24renal cell carcinoma10.4
25syringoma10.3ESR1, PGR
26endocrine organ benign neoplasm10.3ESR1, PGR
27cervical benign neoplasm10.3ESR1, PGR
28large bowel leiomyoma10.3ESR1, PGR
29bile duct cystadenoma10.3ESR1, PGR
30glaucoma iridogoniodysgenesia10.3ESR1, PGR
31venous tributary occlusion of retina10.3ESR1, PGR
32deafness, autosomal dominant 8/1210.3ESR1, PGR
33peroneal nerve paralysis10.3ESR1, PGR
34situs inversus10.3ESR1, PGR
35vulvar squamous papilloma10.3ESR1, PGR
36heritable pulmonary arterial hypertension10.3FH, SDHB
37childhood choriocarcinoma of the ovary10.3ESR1, PGR
38extragonadal nonseminomatous germ cell tumor10.3ESR1, PGR
39esophageal adenoid cystic carcinoma10.3ESR1, PGR
40ureter adenocarcinoma10.3ESR1, PGR
41dental pulp calcification10.3ESR1, PGR
42spondylitis10.3ESR1, PGR
43vulvar alveolar soft part sarcoma10.3ESR1, PGR
44rectum mucinous adenocarcinoma10.3ESR1, PGR
45follicular basal cell carcinoma10.3ESR1, PGR
46childhood mediastinal neurogenic tumor10.3ESR1, PGR
47apocrine adenosis of breast10.3ESR1, PGR
48retroperitoneal sarcoma10.3ESR1, PGR
49uterine corpus adenosarcoma10.3ESR1, PGR
50renal pelvis squamous cell carcinoma10.3ESR1, PGR

Graphical network of the top 20 diseases related to Leiomyomatosis:



Diseases related to leiomyomatosis

Symptoms for Leiomyomatosis

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Drugs & Therapeutics for Leiomyomatosis

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Drugs for Leiomyomatosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Phase 4
2
Bevacizumabapproved, investigationalPhase 21875216974-75-3
Synonyms:
216974-75-3
Avastin
Avastin (TN)
Bevacizumab
Bevacizumab (genetical recombination)
 
Bevacizumab (genetical recombination) (JAN)
D06409
R-435
anti-VEGF monoclonal antibody
antiVEGF
bevacizumab
3
MetforminapprovedPhase 1, Phase 21645657-24-9, 1115-70-414219, 4091
Synonyms:
1,1-Dimethyl biguanide
1,1-Dimethylbiguanide
3-(diaminomethylidene)-1,1-dimethylguanidine
657-24-9
AC1L1HE4
AKOS000121065
Apo-Metformin
BIDD:GT0697
BPBio1_000009
BRD-K79602928-003-04-1
BSPBio_000007
BSPBio_002314
C07151
C4H11N5
CAS-1115-70-4
CCRIS 9321
CHEBI:6801
CHEMBL1431
CID4091
D04966
DB00331
DMBG
DMGG
Diabefagos
Diabetosan
Diabex
Diaformin
Dianben
Dimethylbiguanid
Dimethylbiguanide
Dimethylbiguanidine
Dimethyldiguanide
Dimethylguanylguanidine
EINECS 211-517-8
Fluamine
Flumamine
Fortamet
Gen-Metformin
Glifage
Gliguanid
Glucophage
Glucophage XR
Glumetza
Glycon
HMS2089D19
HSCI1_000295
Haurymelin
Haurymellin
Islotin
KBio2_002310
KBio2_004878
KBio2_007446
KBio3_002790
KBioGR_002310
 
KBioSS_002312
LA-6023
LS-43899
Meguan
Melbin
Metformin
Metformin (USAN/INN)
Metformin HCL
Metformin Hydrochloride
Metformin [USAN:INN:BAN]
Metformina
Metformina [DCIT]
Metformina [Spanish]
Metformine
Metformine [INN-French]
Metformine pamoate
Metforminum
Metforminum [INN-Latin]
Metiguanide
MolPort-002-929-560
MolPort-004-288-389
MolPort-005-767-418
Mylan-Metformin
N,N-Dimethylbiguanide
N,N-Dimethyldiguanide
N,N-Dimethylimidodicarbonimidic diamide
N,N-dimethylimidodicarbonimidic diamide
N1,N1-Dimethylbiguanide
NCGC00016564-01
NCGC00016564-02
NCGC00016564-03
NNDG
Novo-Metformin
Nu-Metformin
Obimet
PMS-Metformin
Prestwick0_000004
Prestwick1_000004
Prestwick2_000004
Prestwick3_000004
Ran-Metformin
Ratio-Metformin
Riomet
S2483_Selleck
SPBio_001928
STK011633
Sandoz Metformin
Siofor
T5895664
Teva-Metformin
UNII-9100L32L2N
ZINC12859773
cMAP_000016
metformin
metformin hydrochloride
4
AcetylcholineexperimentalPhase 268951-84-3187
Synonyms:
ACh
Acetyl choline ion
Acetylcholine Chloride
Acetylcholine cation
 
Acetylcholinium: acetyl-Choline
Choline acetate
Choline acetate (ester)
Miochol E
O-Acetylcholine
acetylcholine chloride
5Neurotransmitter AgentsPhase 214795
6Peripheral Nervous System AgentsPhase 218510
7Neuromuscular AgentsPhase 2922
8OnabotulinumtoxinAPhase 2588
9AbobotulinumtoxinAPhase 2588
10IncobotulinumtoxinAPhase 2599
11Botulinum ToxinsPhase 2616
12Botulinum Toxins, Type APhase 2588
13Cholinergic AgentsPhase 23243
14Hypoglycemic AgentsPhase 1, Phase 24503
15Protein Kinase InhibitorsPhase 23162
16
Erlotinib HydrochloridePhase 2781183319-69-9176871
Synonyms:
 
erlotinib hydrochloride
17Angiogenesis InhibitorsPhase 23688
18Angiogenesis Modulating AgentsPhase 23611
19
Progesteroneapproved50057-83-05994
Synonyms:
(S)-4-Pregnene-3,20-dione
(S)-Pregn-4-en-3,20-dione
(S)-Progesterone
.beta.-Progesterone
.delta.(sup4)-Pregnene-3,20-dione
.delta.4-Pregnene-3,20-dione
17.alpha.-Progesterone
17a-Progesterone
17alpha-Progesterone
17alpha-progesterone
17α-progesterone
1dbb
1h60
257630-50-5
3,20-Pregnene-4
32104FB6-BF81-4F6E-83C2-024DEEAEB272
4-Pregnen-3,20-dione
4-Pregnene-3,20-dione
46665_FLUKA
46665_RIEDEL
57-83-0
753497-20-0
8012-32-6
8023-13-0
AC-700
AC1L1LKF
AI3-51682
Agolutin
Akrolutin
BB_NC-0185
BHR-100
BIDD:ER0547
BIDD:PXR0094
BPBio1_000676
BRD-K64994968-001-03-6
BSPBio_000614
Bio-luton
C00410
CCRIS 533
CHEBI:17026
CHEMBL103
CID5994
CIDR
CMC_13406
COL-1620
CPD000058345
Colprosterone
Corlutin
Corlutina
Corluvite
Corporin
Corpus Luteum Hormone
Corpus luteum hormone
Crinone
Crinone (TN)
Crinone progesterone gel
Curretab
Cyclogest
Cyclogesterin
D00066
D4-Pregnene-3,20-dione
DB00396
DR-2011
Delalutin
Delta(4)-pregnene-3,20-dione
Duraprogen
EINECS 200-350-6
ETI-411
EU-0100895
Endometrin
Estima
FE-999913
Flavolutan
Fologenon
Gelbkoerperhormon
Gesterol
Gesterol 100
Gesterol 50
Gestiron
Gestone
Gestormone
Gestron
Glanducorpin
Gynlutin
Gynoluton
Gynolutone
HMS1569O16
HMS2051O05
HMS2090J07
HSDB 3389
Hormoflaveine
Hormoluton
Hydroxyprogesterone Caproate
Hydroxyprogesterone Caproic acid
LMST02030159
LS-234
Lingusorbs
Lipo-Lutin
Lipolutin
Lopac0_000895
Lucorteum
Lucorteum Sol
Lucorteum sol
Lugesteron
Luteal hormone
Luteinique
Luteocrin normale
Luteodyn
Luteogan
Luteohormone
Luteol
Luteol (VAN)
Luteopur
Luteosan
Luteostab
Luteovis
Luteum
Lutex
Lutidon
Lutin
Lutinus
Lutociclina
Lutocuclin M
Lutocyclin
Lutocyclin M
 
Lutocyclin m
Lutocylin
Lutocylol
Lutoform
Lutogyl
Lutogynon
Lutren
Lutromone
MLS000028517
MLS000758277
MLS001074187
MLS002222367
MPA
Membrettes
Methylpregnone
Micronized Progesterone
MolPort-001-794-643
NCGC00022185-03
NCGC00022185-04
NCGC00022185-05
NCGC00022185-06
NCGC00022185-07
NCGC00022185-08
NCGC00022185-09
NCGC00090798-01
NCGC00090798-02
NCI60_042166
NSC 64377
NSC 9704
NSC-9704
NSC64377
NSC9704
Nalutron
Natural Progesterone
P 0130
P0130_SIGMA
P0478
P3972_SIGMA
P6149_SIGMA
P7556_ALDRICH
P7556_SIGMA
P8783_SIGMA
P9776_SIGMA
PROGESTERONE
Percutacrine
Percutacrine Luteinique
Piaponon
Pranone
Pregn-4-en-3,20-dione
Pregn-4-ene-3,20-dione
Pregnene-3,20-dione
Pregnenedione
Prestwick0_000477
Prestwick1_000477
Prestwick2_000477
Prestwick3_000477
Prestwick_411
Primolut
Prochieve
Progeffik
Progekan
Progestan
Progestasert
Progesterol
Progesteron
Progesterona
Progesterona [INN-Spanish]
Progesterone
Progesterone (JP15/USP/INN)
Progesterone [INN:BAN:JAN]
Progesterone [Progestins]
Progesterone, water-soluble
Progesterone-Water Soluble
Progesterone: HBC complex
Progesteronum
Progesteronum [INN-Latin]
Progestin
Progestogel
Progestol
Progeston
Progestone
Progestosol
Progestrel
Progestron
Progestronol
Progestérone
Projestaject
Prolets
Prolidon
Prolutin
Proluton
Prolutone
Prometrium
Prometrium (TN)
Prontogest
Protormone
S00293
S1705_Selleck
SAM001247039
SMR000058345
SMR000653542
SPBio_002553
SR-01000000088
SR-01000000088-5
Spectrum5_002053
Syngesterone
Syngestrets
Synovex S
Syntolutan
U 3672
UNII-4G7DS2Q64Y
Utrogest
Utrogestan
Vitarrine
WLN: L E5 B666 OV MUTJ A1 E1 FV1
ZINC04428529
beta-Progesterone
bmse000482
component of Cyclogesterin
corpus luteum hormone
delta(4)-Pregnene-3,20-dione
delta(Sup 4)-Pregnene-3,20-dione
delta(Sup4)-pregnene-3,20-dione
delta(sup 4)-Pregnene-3,20-dione
delta4-Pregnene-3,20-dione
luteohormone
nchembio.2007.53-comp14

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Prospective Study Comparing Contour SE™ Microspheres to Embosphere® Microspheres for Treating Symptomatic Uterine Fibroids With Uterine Fibroid Embolization (UFE)CompletedNCT00628901Phase 4
2Randomized Pilot Study for the Treatment of Cutaneous Leiomyomas With Botulinum ToxinCompletedNCT00971620Phase 2
3A Phase II Study of Bevacizumab and Erlotinib in Subjects With Advanced Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC) or Sporadic Papillary Renal Cell CancerRecruitingNCT01130519Phase 2
4Vandetanib in Combination With Metformin in People With HLRCC or SDH-Associated Kidney Cancer or Sporadic Papillary Renal Cell CarcinomaRecruitingNCT02495103Phase 1, Phase 2
5Comparison Study in the Treatment of Uterine Fibroids Uterine Fibroid Embolization Using BeadBlock™ Embolic AgentCompletedNCT00361036Phase 1
6Surgery for Intravenous LeiomyomatosisCompletedNCT01707862
7Official Record of Patients Diagnosed With Lymphangioleiomyomatosis (LAM)CompletedNCT00001869
8Establishment of Fibroid Tissue BankCompletedNCT00710346
9Hereditary Leiomyomatosis Renal Cell Cancer - Study of the Genetic Cause and the Predisposition to Renal CancerRecruitingNCT00050752

Search NIH Clinical Center for Leiomyomatosis


Cochrane evidence based reviews: leiomyomatosis

Genetic Tests for Leiomyomatosis

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Anatomical Context for Leiomyomatosis

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MalaCards organs/tissues related to Leiomyomatosis:

33
Uterus, Breast, Smooth muscle, Heart, Thyroid, Prostate, Ovary

Animal Models for Leiomyomatosis or affiliated genes

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MGI Mouse Phenotypes related to Leiomyomatosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.5COL4A4, COL4A5, ESR1, FH, GNRH1
2MP:00028738.0COL4A6, ESR1, GNRH1, LDHA, MED12, PGR
3MP:00053857.4COL4A5, ESR1, LDHA, MED12, PGR, SDHB
4MP:00107686.3COL4A4, COL4A5, ESR1, FH, LDHA, MED12

Publications for Leiomyomatosis

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Articles related to Leiomyomatosis:

(show top 50)    (show all 614)
idTitleAuthorsYear
1
Intravenous leiomyomatosis: an unusual intermediate between benign and malignant uterine smooth muscle tumors. (26892441)
2016
2
Immunohistochemistry for 2-Succinocysteine (2SC) and Fumarate Hydratase (FH) in Cutaneous Leiomyomas May Aid in Identification of Patients With HLRCC (Hereditary Leiomyomatosis and Renal Cell Carcinoma Syndrome). (26945337)
2016
3
A Case of Hereditary Leiomyomatosis and Renal Cell Carcinoma. (27144040)
2016
4
Single-stage operation using hypothermic circulatory arrest to remove uterine intravenous leiomyomatosis extended to the vena cava and right atrium. (25579748)
2015
5
Molecular Genetic Alterations in Renal Cell Carcinomas With Tubulocystic Pattern: Tubulocystic Renal Cell Carcinoma, Tubulocystic Renal Cell Carcinoma With Heterogenous Component and Familial Leiomyomatosis-associated Renal Cell Carcinoma. Clinicopathologic and Molecular Genetic Analysis of 15 Cases. (26447894)
2015
6
Leiomyomas beyond the uterus; benign metastasizing leiomyomatosis with paraaortic metastasizing endometriosis and intravenous leiomyomatosis: a case series and review of the literature. (25047270)
2014
7
Post-transplant diagnosis of hereditary leiomyomatosis and renal cell carcinoma syndrome in a kidney donor. (25859385)
2014
8
eComment. Misdiagnosis of intravenous leiomyomatosis with cardiac extension. (23785088)
2013
9
Diffuse peritoneal leiomyomatosis. (23815223)
2013
10
Cutaneous clues to renal cell carcinoma: hereditary leiomyomatosis and renal cell carcinoma. (23652956)
2013
11
Management of intravascular leiomyomatosis: laparoscopic surgery for ordinary uterine fibroids led to an extraordinary finding. (23454251)
2013
12
A case of intravenous leiomyomatosis of uterine origin, extending through the inferior vena cava to right atrium. (22627954)
2013
13
Diffuse uterine leiomyomatosis in a child. (21710273)
2012
14
Intracardiac and intravenous leiomyomatosis. (23036637)
2012
15
Case 188: Intravenous leiomyomatosis with intracaval and intracardiac involvement. (23175549)
2012
16
Intravenous leiomyomatosis of the uterus with extension to the right heart. (21943238)
2011
17
Partial resection of intravenous leiomyomatosis with cardiac extension. (21225399)
2011
18
AIRP best cases in radiologic-pathologic correlation: intravenous leiomyomatosis. (21768238)
2011
19
Novel FH mutation in a patient with cutaneous leiomyomatosis associated with cutis verticis gyrata, eruptive collagenoma and Charcot-Marie-Tooth disease. (20560959)
2010
20
Intravenous leiomyomatosis with intracardiac extension: first reported case in Australia. (19423390)
2010
21
Evidence for a new fumarate hydratase gene mutation in a unilateral type 2 segmental leiomyomatosis. (20628236)
2010
22
Type 2 segmental cutaneous leiomyomatosis: an example of mosaicism. (19109093)
2009
23
Leiomyomatosis of the esophagus: experience over a decade. (18818979)
2009
24
Wilms tumour as a possible early manifestation of hereditary leiomyomatosis and renal cell cancer? (19183174)
2009
25
Esophageal leiomyomatosis combined with intrathoracic stomach and gastric volvulus. (19793488)
2009
26
Successful management of a leiomyomatosis peritonealis disseminata with an aromatase inhibitor. (18669776)
2008
27
Mechanisms of disease: hereditary leiomyomatosis and renal cell cancer--a distinct form of hereditary kidney cancer. (17287871)
2007
28
From gene to disease; cutaneous leiomyomatosis]. (17326474)
2007
29
Uterine plexiform leiomyomatosis with an intrinsic granulomatous response. (16581663)
2006
30
Type 2 segmental manifestation of cutaneous leiomyomatosis in four unrelated women with additional uterine leiomyomas (Reed's Syndrome). (16319483)
2006
31
Intravenous uterine leiomyomatosis with right heart extension: successful two-stage surgical removal. (16583249)
2006
32
Missense mutations in fumarate hydratase in multiple cutaneous and uterine leiomyomatosis and renal cell cancer. (16237213)
2005
33
Pre- and postoperative MRI of esophageal and gastric leiomyomatosis in a pediatric patient. (15728005)
2005
34
Hereditary leiomyomatosis associated with bilateral, massive, macronodular adrenocortical disease and atypical cushing syndrome: a clinical and molecular genetic investigation. (15741255)
2005
35
Esophageal leiomyomatosis diagnosed by endoscopic ultrasound. (15731952)
2005
36
Successful one-stage radical removal of intravenous leiomyomatosis extending to the right ventricle. (15121610)
2004
37
Low frequency of somatic mutations in the FH/multiple cutaneous leiomyomatosis gene in sporadic leiomyosarcomas and uterine leiomyomas. (12177782)
2002
38
Ovarian endometriosis and clear cell carcinoma, leiomyomatosis peritonealis disseminata, and endometrial adenocarcinoma: an unusual, pathogenetically related association. (11444203)
2001
39
Late intracaval and intracardiac leiomyomatosis following hysterectomy for benign myomas treated by surgery and GnRH agonist. (11606110)
2001
40
Diffuse esophageal leiomyomatosis: another cause of pseudoachalasia. (14601910)
2000
41
Diffuse leiomyomatosis of the uterus: a case report with clonality analysis. (11112221)
2000
42
Intravenous leiomyomatosis with caval involvement: report of a case with radical resection and venous replacement. (9565130)
1998
43
Topoisomerase I and II consensus sequences in a 17-kb deletion junction of the COL4A5 and COL4A6 genes and immunohistochemical analysis of esophageal leiomyomatosis associated with Alport syndrome. (9463311)
1998
44
Leiomyomatosis peritonealis disseminata occurring in a postmenopausal woman: report of a case. (8883241)
1996
45
Leuprolide acetate and intravascular leiomyomatosis. (7675416)
1995
46
Leiomyomatosis peritonealis disseminata. A report of two cases. (7996533)
1994
47
Recurrent pelvic intravenous leiomyomatosis. (7465135)
1981
48
Intravenous leiomyomatosis of the uterus with extension into the heart. (7416191)
1980
49
Intravenous leiomyomatosis of the uterus. A report of four cases. (13904785)
1961
50

Variations for Leiomyomatosis

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Expression for genes affiliated with Leiomyomatosis

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Search GEO for disease gene expression data for Leiomyomatosis.

GO Terms for genes affiliated with Leiomyomatosis

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Cellular components related to Leiomyomatosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1perikaryonGO:004320410.0ESR1, GNRH1
2collagen type IV trimerGO:00055879.7COL4A4, COL4A5, COL4A6
3mitochondrionGO:00057398.5ESR1, FH, GNRH1, SDHB

Biological processes related to Leiomyomatosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1collagen catabolic processGO:00305749.6COL4A4, COL4A6
2transcription initiation from RNA polymerase II promoterGO:00063679.3ESR1, MED12, PGR
3extracellular matrix disassemblyGO:00226179.3COL4A4, COL4A5, COL4A6
4response to estrogenGO:00436279.2ESR1, LDHA

Sources for Leiomyomatosis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet