Leiomyomatosis malady

Wikipedia: A leiomyoma (plural is \'leiomyomata\') is a benign smooth muscle neoplasm that is very rarely (0.1%)...⁴⁴ more...

MalaCards: Leiomyomatosis, also known as leiomyomatosis, no icd-o subtype (morphologic abnormality), is related to hereditary leiomyomatosis and renal cell cancer and leiomyomatosis and renal cell cancer. An important gene associated with Leiomyomatosis is COL4A6 (collagen, type IV, alpha 6), and among its related pathways are Selected targets of ESR1 and Protein digestion and absorption. The compounds Ethynodiol Diacetate and ici 164384 have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, colon and kidney, and related mouse phenotypes are embryogenesis and normal.

Aliases & Descriptions:

leiomyomatosis 6 7 8 32 43 leiomyomatosis, no icd-o subtype (morphologic abnormality) 6

Diseases related to leiomyomatosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 255)

id	Related Disease	Score	Top Affiliating Genes
1	hereditary leiomyomatosis and renal cell cancer	35.1	SDHB, FH
2	leiomyomatosis and renal cell cancer	33.8	BNIP3, LDHA, FH, THBS1
3	alport syndrome	32.3	COL4A5, COL4A6, COL4A3, COL4A4
4	intravenous leiomyomatosis	32.2	IVL, ESR1, NT5C1B, ACTC1, DES
5	myoma	28.0	DES, PGR
6	kidney cancer	27.3	VHL, SDHB, FLCN, FH
7	lymphangioleiomyomatosis	27.1	TSC1, DES
8	uterine fibroid	27.0	FH, GNRH1, ESR1, THBS1, DES, PGR
9	ovarian endometriosis	26.4	INHA, ESR1, PGR
10	esophagitis	26.2	VIM, VHL, IVL, ESR1, COL4A5, COL4A6
11	cushing's syndrome	26.1	LHCGR, INHA, GNRH1
12	leiomyosarcoma	25.5	VIM, INHA, FH, GNRH1, ESR1, ACTC1
13	renal cell carcinoma	25.4	VIM, VHL, SDHB, FLCN, INHA, FH
14	renal carcinoma	25.3	VIM, VHL, LDHA, FLCN, FH, TSC1
15	tuberous sclerosis	24.9	VIM, VHL, FLCN, ESR1, ACTC1, TSC1
16	peritonitis	24.5	VIM, VHL, BNIP3, ITGA5, INHA, GNRH1
17	endometriosis	24.1	VIM, LAMB1, ITGA5, INHA, GNRH1, ESR1
18	leiomyoma	23.9	VIM, LAMB1, IVL, FLCN, FH, GNRH1
19	nephropathy	23.7	SDHB, LAMB1, ESR1, COL4A5, COL4A3, COL4A4
20	hypoxia	22.9	VHL, BNIP3, SDHB, LHCGR, LDHA, IVL
21	adenocarcinoma	21.7	VIM, VHL, BNIP3, LDHA, LAMB1, IVL
22	carcinoma	21.0	VIM, VHL, BNIP3, SDHB, LHCGR, LDHA
23	malignant giant cell tumor of soft parts	13.6	ACTC1, DES
24	vulvar syringoma	13.6	ESR1, PGR
25	leydig cell adenoma	13.5	LHCGR, GNRH1
26	glassy cell carcinoma of the cervix	13.5	ESR1, PGR
27	cribriform carcinoma	13.5	ESR1, PGR
28	progesterone resistance	13.5	ESR1, PGR
29	vhl-related pheochromocytoma	13.5	VHL, SDHB
30	gastric leiomyosarcoma	13.5	DES, PGR
31	glomangioma	13.5	ACTC1, DES
32	gender identity disorder	13.5	ESR1, PGR
33	progesterone-receptor positive breast cancer	13.4	ESR1, PGR
34	mammary paget's disease	13.4	ESR1, PGR
35	cellular leiomyoma	13.4	ESR1, DES, PGR
36	cystic fibrosis	13.4	ESR1, PGR
37	carney triad	13.4	SDHB, ACTC1, DES
38	meningioma	13.4	ESR1, PGR
39	familial renal cell carcinoma	13.4	VHL, SDHB, FH
40	catamenial pneumothorax	13.4	GNRH1, ESR1, PGR
41	breast fibroadenoma	13.4	ESR1, THBS1, PGR
42	tubular adenocarcinoma	13.4	ESR1, ACTC1, PGR
43	cervical endometrioid adenocarcinoma	13.3	ESR1, PGR
44	transsexualism	13.3	GNRH1, ESR1, PGR
45	prostatic hypertrophy	13.3	GNRH1, ESR1, PGR
46	lymph node palisaded myofibroblastoma	13.3	VIM, DES
47	myxosarcoma	13.3	VIM, DES
48	infantile digital fibromatosis	13.3	VIM, DES
49	prostate leiomyoma	13.3	VIM, DES
50	meninges sarcoma	13.3	VIM, DES

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to leiomyomatosis:

²²

MGI Mouse Phenotypes related to leiomyomatosis:

²⁵ (show all 12)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	embryogenesis phenotype	MP:0005380	8.2	PGR, PPRC1, FLCN, ITGA5, VHL, VIM
2	normal phenotype	MP:0002873	8.1	ACTC1, COL4A6, GNRH1, INHA, ITGA5, IVL
3	muscle phenotype	MP:0005369	8.1	PGR, DES, THBS1, TSC1, ACTC1, ESR1
4	tumorigenesis	MP:0002006	7.9	PGR, THBS1, TSC1, ESR1, GNRH1, INHA
5	reproductive system phenotype	MP:0005389	7.2	PGR, PRND, THBS1, TSC1, ESR1, GNRH1
6	renal/urinary system phenotype	MP:0005367	7.1	THBS1, TSC1, COL4A4, COL4A3, COL4A5, ESR1
7	cellular phenotype	MP:0005384	6.9	ESR1, ACTC1, TSC1, THBS1, PGR, GNRH1
8	immune system phenotype	MP:0005387	6.8	COL4A5, COL4A3, THBS1, PRND, PGR, ESR1
9	mortality/aging	MP:0010768	6.1	DES, TSC1, COL4A4, COL4A3, COL4A5, PPRC1
10	growth/size phenotype	MP:0005378	6.1	COL4A3, COL4A4, ACTC1, TSC1, THBS1, ESR1
11	cardiovascular system phenotype	MP:0005385	5.8	COL4A3, ACTC1, TSC1, THBS1, DES, PGR
12	homeostasis/metabolism phenotype	MP:0005376	5.1	VIM, PGR, DES, THBS1, TSC1, ACTC1

Articles related to leiomyomatosis:

(show top 50)    (show all 61)

id	Title	Authors	Year	Affiliating Genes
1	Clonal overgrowth of esophageal smooth muscle cells i n diffuse leiomyomatosis-Alport syndrome caused by partial deletion in COL4A5 a nd COL4A6 genes. (20951201)	Oohashi T.... Ninomiya Y.	2011	COL4A6, COL4A5
2	Alport syndrome and leiomyomatosis: the first deletio n extending beyond COL4A6 intron 2. (21380622)	Uliana V.... Salviati L.	2011	COL4A6, COL4A5
3	Hereditary leiomyomatosis and renal cell cancer in fa milies referred for fumarate hydratase germline mutation analysis. (20618355)	Smit D.L.... Menko F.H.	2011	FH
4	UOK 262 cell line, fumarate hydratase deficient (FH-/ FH-) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer. (19963135)	Yang Y.... Linehan W.M.	2010	LDHA, FH
5	Clinical and molecular genetic aspects of hereditary multiple cutaneous leiomyomatosis. (19939761)	Badeloe S.... Frank J.	2009	FH
6	Array comparative genomic hybridization identifies a distinct DNA copy number profile in renal cell cancer associated with hereditar y leiomyomatosis and renal cell cancer. (19373782)	Koski T.A.... Launonen V.	2009	FH
7	LDH-A inhibition, a therapeutic strategy for treatmen t of hereditary leiomyomatosis and renal cell cancer. (19276158)	Xie H.... Seth P.	2009	LDHA, FH
8	Intravenous leiomyomatosis with intracardiac extension: a case report (19088839)	Zhang T.... Li Q.L.	2008	DES
9	Association of germline mutations in the fumarate hydratase gene and uterine fibroids in women with hereditary leiomyomatosis and renal cell cancer. (19075141)	Stewart L.... Toro J.R.	2008	FH
10	Mutation screening of fumarate hydratase by multiplex ligation-dependent probe amplification: detection of exonic deletion in a patient with leiomyomatosis and renal cell cancer. (18503824)	Ahvenainen T.... Launonen V.	2008	FH
11	Mechanisms of disease: hereditary leiomyomatosis and renal cell cancer--a distinct form of hereditary kidney cancer. (17287871)	Sudarshan S.... Linehan W.M.	2007	FH
12	From gene to disease; cutaneous leiomyomatosis (17326474)	Badeloe S.... Frank J.A.	2007	FH
13	Hereditary leiomyomatosis and renal cell cancer: an unusual and aggressive form of hereditary renal carcinoma. (17392716)	Refae M.A.... Foulkes W.D.	2007	FH
14	The morphologic spectrum of kidney tumors in hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndrome. (17895761)	Merino M.J.... Linehan W.M.	2007	FH
15	Diffuse and segmental variants of cutaneous leiomyomatosis: novel mutations in the fumarate hydratase gene and review of the literature. (16881969)	Badeloe S.... Poblete-Gutierrez P.	2006	FH
16	Disseminated peritoneal leiomyomatosis coexisting wit h leiomyoma of the uterine body. (16341539)	Surmacki P.... Lasota J.	2006	ACTC1
17	CD10 in diffuse uterine leiomyomatosis: a case report along with a few comments on histogenesis. (17001917)	Jambhekar N.A.... Chaturvedi A.	2006	VIM, DES, ACTC1
18	Novel mutations in FH and expansion of the spectrum of phenotypes expressed in families with hereditary leiomyomatosis and renal cell cancer. (15937070)	Wei M.H.... Toro J.R.	2006	FH
19	Hereditary leiomyomatosis associated with bilateral, massive, macronodular adrenocortical disease and atypical cushing syndrome: a clinical and molecular genetic investigation. (15741255)	Matyakhina L.... Stratakis C.A.	2005	FH
20	Evidence of increased microvessel density and activation of the hypoxia pathway in tumours from the hereditary leiomyomatosis and renal cell cancer syndrome. (15586379)	Pollard P.... Tomlinson I.	2005	THBS1, FH, BNIP3
21	Clinical features of multiple cutaneous and uterine leiomyomatosis: an underdiagnosed tumor syndrome. (15724016)	Alam N.A.... Tomlinson I.P.	2005	FH
22	Mutations in fumarate hydratase during cutaneous and uterine leiomyomatosis associated with renal cancer (15924063)	Dereure O.	2005	FH
23	Missense mutations in fumarate hydratase in multiple cutaneous and uterine leiomyomatosis and renal cell cancer. (16237213)	Alam N.A.... Weaver T.	2005	FH
24	Familial leiomyomatosis cutis et uteri. (15748575)	Cassetty C.T.	2004	FH
25	Hereditary leiomyomatosis and renal cell cancer (HLRCC). (15579034)	Kiuru M.... Launonen V.	2004	FH
26	Familial leiomyomatosis: a review and discussion of pathogenesis. (12920381)	Garman M.E.... Raimer S.S.	2003	FH
27	Mutations in the fumarate hydratase gene cause hereditary leiomyomatosis and renal cell cancer in families in North America. (12772087)	Toro J.R.... Zbar B.	2003	FH
28	Alport syndrome with diffuse leiomyomatosis. (12784310)	Anker M.C.... Koenig R.	2003	COL4A6, COL4A5
29	Genetic and functional analyses of FH mutations in multiple cutaneous and uterine leiomyomatosis, hereditary leiomyomatosis and renal cancer, and fumarate hydratase deficiency. (12761039)	Alam N.A.... Tomlinson I.P.	2003	FH
30	Deletion mapping in Alport syndrome and Alport syndrome-diffuse leiomyomatosis reveals potential mechanisms of visceral smooth muscle overgrowth. (14517961)	Thielen B.K.... Segal Y.	2003	COL4A6, COL4A5
31	Low frequency of somatic mutations in the FH/multiple cutaneous leiomyomatosis gene in sporadic leiomyosarcomas and uterine leiomyomas. (12177782)	Barker K.T.... Houlston R.S.	2002	FH
32	Few FH mutations in sporadic counterparts of tumor types observed in hereditary leiomyomatosis and renal cell cancer families. (12183404)	Kiuru M.... Aaltonen L.A.	2002	FH
33	Alport syndrome associated with diffuse leiomyomatosis: COL4A5-COL4A6 deletion associated with a mild form of Alport nephropathy. (11773466)	Mothes H.... Scheele J.	2002	COL4A5
34	Ovarian endometriosis and clear cell carcinoma, leiomyomatosis peritonealis disseminata, and endometrial adenocarcinoma: an unusual, pathogenetically related association. (11444203)	Guarch R.... Nogales F.F.	2001	INHA
35	Intravenous leiomyomatosis with cardiac extension in an elderly woman: report of a case (11517553)	Kanno M.... Wada Y.	2001	ACTC1
36	Leiomyomatosis-like lymphangioleiomyomatosis of the colon in a female with tuberous sclerosis. (11706076)	Goh S.G.... Riddell R.H.	2001	TSC1
37	Late intracaval and intracardiac leiomyomatosis following hysterectomy for benign myomas treated by surgery and GnRH agonist. (11606110)	Morice P.... LhommAc C.	2001	GNRH1
38	Progesterone receptor activity in leiomyomatosis peritonealis disseminata. (12090595)	Butnor K.J.... Robboy S.J.	1999	PGR, VIM, DES
39	LINE-1 elements at the sites of molecular rearrangements in Alport syndrome-diffuse leiomyomatosis. (9915944)	Segal Y.... Zhou J.	1999	COL4A6
40	Absence of the alpha6(IV) chain of collagen type IV in Alport syndrome is related to a failure at the protein assembly level and does not result in diffuse leiomyomatosis. (10362815)	Zheng K.... Thorner P.S.	1999	COL4A6, COL4A5
41	GnRH agonist for intravenous leiomyomatosis with card iac extension. A case report. (10554751)	Mitsuhashi A.... Sekiya S.	1999	ESR1
42	Topoisomerase I and II consensus sequences in a 17-kb deletion junction of the COL4A5 and COL4A6 genes and immunohistochemical analysis of esophageal leiomyomatosis associated with Alport syndrome. (9463311)	Ueki Y.... Ninomiya Y.	1998	COL4A6, COL4A5
43	Novel COL4A5/COL4A6 deletions and further characterization of the diffuse leiomyomatosis-Alport syndrome (DL-AS) locus define the DL critical region. (9465897)	Heidet L.... Antignac C.	1997	COL4A6, COL4A5
44	Structure of the human type IV collagen COL4A6 gene, which is mutated in Alport syndrome-associated leiomyomatosis. (8661006)	Zhang X.... Tryggvason K.	1996	COL4A3, COL4A6, COL4A5
45	Leiomyomatosis peritonealis disseminata (LPD) with acute ascites induced by gonadotropin-releasing hormone (GnRH) agonist: a case report. (9041767)	Tseng C.W.... Chang S.Y.	1996	GNRH1
46	Short-term treatment with leuprolide acetate depot b efore surgical intervention for uterine leiomyomatosis (7936386)	D'Anna R.... Leonardi I.	1994	ESR1
47	Type IV collagen: structure, gene organization, and role in human diseases. Molecular basis of Goodpasture and Alport syndromes and diffuse leiomyomatosis. (8253711)	Hudson B.G.... Tryggvason K.	1993	COL4A4
48	Hereditary Leiomyomatosis and Re nal Cell Cancer (20301430)	Pithukpakorn M.... Toro J.R.	1993	FH
49	Alport syndrome and diffuse leiomyomatosis: deletions in the 5' end of the COL4A5 collagen gene. (1453602)	Antignac C.... Tryggvason K.	1992	COL4A5
50	Medical treatment of uterine leiomyomatosis with an agonist of pituitary gonadotropins (GnRH). Presentation of a case (2125961)	Bustos H.H.... Ayala Ruiz A.	1990	GNRH1

Genes related to leiomyomatosis according to GeneCards:

(show all 27)

id	Symbol	Description	Score	GeneCards Section Context
1	COL4A6	collagen, type IV, alpha 6	11.1	Summaries, Publications
2	FH	fumarate hydratase	11.0	Publications
3	LDHA	lactate dehydrogenase A	11.0	Publications
4	BNIP3	BCL2/adenovirus E1B 19kDa interacting protein 3	11.0	Publications
5	THBS1	thrombospondin 1	11.0	Publications
6	ESR1	estrogen receptor 1	11.0	Publications
7	NT5C1B	5'-nucleotidase, cytosolic IB	11.0
8	COL4A5	collagen, type IV, alpha 5	11.0	Publications
9	ACTC1	actin, alpha, cardiac muscle 1	11.0	Publications
10	LHCGR	luteinizing hormone/choriogonadotropin receptor	11.0	Publications
11	DES	desmin	11.0	Publications
12	IVL	involucrin	11.0
13	VHL	von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase	11.0
14	GNRH1	gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)	11.0	Publications
15	SDHB	succinate dehydrogenase complex, subunit B, iron sulfur (Ip)	11.0
16	PGR	progesterone receptor	11.0	Publications
17	PPRC1	peroxisome proliferator-activated receptor gamma, coactivator-related 1	11.0
18	PRND	prion protein 2 (dublet)	11.0
19	COL9A2	collagen, type IX, alpha 2	11.0	Orthologs
20	FLCN	folliculin	11.0
21	ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	11.0	Publications
22	LAMB1	laminin, beta 1	11.0	Publications
23	COL4A4	collagen, type IV, alpha 4	11.0	Publications
24	INHA	inhibin, alpha	11.0	Publications
25	TSC1	tuberous sclerosis 1	11.0	Publications
26	COL4A3	collagen, type IV, alpha 3 (Goodpasture antigen)	11.0	Publications
27	VIM	vimentin	11.0	Publications

Pathways related to leiomyomatosis according to GeneDecks:

(show all 35)

id	Pathway	Score	Top Affiliating Genes
1	Selected targets of ESR110	9.8	ESR1, COL9A2, THBS1
2	Protein digestion and absorption20	9.4	COL4A5, COL9A2, COL4A6, COL4A4
3	Small cell lung cancer20	9.3	COL4A4, COL4A6, COL4A5, LAMB1
4	Pathways in cancer20	9.2	COL4A4, COL4A6, COL4A5, FH, LAMB1
5	ECM-receptor interaction20	9.1	THBS1, COL4A4, COL4A6, COL4A5, ITGA5, LAMB1
6	Platelet Aggregation Inhibitor Pathway, Pharmacodynamics34	9.0	COL4A4, COL4A3, COL4A6, COL4A5
7	Amoebiasis20	9.0	COL4A4, COL4A6, COL4A5, LAMB1
8	Focal adhesion20	8.9	THBS1, COL4A4, COL4A6, COL4A5, ITGA5, LAMB1
9	Intrinsic Prothrombin Activation Pathway36	8.8	COL4A4, COL4A3, COL4A6, COL9A2, COL4A5
10	Cell adhesion_Plasmin signaling41	8.8	COL4A4, COL4A3, COL4A6, COL4A5, LAMB1
11	Blood Coagulation Cascade36	8.8	COL4A4, COL4A3, COL4A6, COL9A2, COL4A5
12	Cell adhesion Plasmin signaling10	8.8	COL4A4, COL4A3, COL4A6, COL4A5, LAMB1
13	Metalloproteases in connective tissue degradation10	8.8	COL4A4, COL4A3, COL4A6, COL4A5, LAMB1
14	Cell adhesion Endothelial cell contacts by non-junctional mechanisms10	8.5	LAMB1, COL4A4, COL4A3, COL4A6, COL4A5, ITGA5
15	Cell adhesion_Endothelial cell contacts by non-junctional mechanisms41	8.5	COL4A4, COL4A3, COL4A6, COL4A5, ITGA5, LAMB1
16	Cell adhesion_ECM remodeling41	8.5	ITGA5, COL4A5, COL4A6, COL4A3, COL4A4, LAMB1
17	Cell adhesion ECM remodeling10	8.5	COL4A4, LAMB1, ITGA5, COL4A5, COL4A6, COL4A3
18	Cytoskeleton remodeling_Integrin outside-in signaling41	8.5	ITGA5, COL4A5, COL4A6, COL4A3, COL4A4, LAMB1
19	Cytoskeleton remodeling Integrin outside-in signaling10	8.5	COL4A4, COL4A3, COL4A6, COL4A5, ITGA5, LAMB1
20	Cell adhesion_Integrin-mediated cell adhesion and migration41	8.4	COL4A4, COL4A3, COL4A6, COL4A5, ITGA5, LAMB1
21	Molecular Mechanisms of Cancer36	8.4	TSC1, COL4A4, COL4A6, COL9A2, COL4A5, GNRH1
22	Cell adhesion Integrin-mediated cell adhesion and migration10	8.4	COL4A4, COL4A3, COL4A6, COL4A5, ITGA5, LAMB1
23	Inhibition of Angiogenesis by TSP136	8.4	THBS1, COL4A4, COL4A3, COL4A6, COL9A2, COL4A5
24	Axon guidance38	8.2	LAMB1, COL4A5, COL9A2, COL4A3, COL4A4
25	UPA-UPAR Pathway36	8.1	COL4A4, COL4A3, COL4A6, COL9A2, COL4A5, ITGA5
26	FAK1 Signaling36	8.1	COL4A4, COL4A3, COL4A6, COL9A2, COL4A5, ITGA5
27	Integrin Pathway36	8.1	COL4A4, COL4A3, COL4A6, COL9A2, COL4A5, ITGA5
28	Transendothelial Migration of Leukocytes36	7.9	COL4A4, COL4A3, COL4A6, COL9A2, COL4A5, ITGA5
29	GnRH Signaling36	7.9	COL4A4, COL4A3, COL4A6, COL9A2, COL4A5, GNRH1
30	PTEN Pathway36	7.9	COL4A4, COL4A3, COL4A6, COL9A2, COL4A5, GNRH1
31	Phospholipase-C Pathway36	7.8	COL4A4, COL4A3, COL4A6, COL9A2, COL4A5, GNRH1
32	MAPK Signaling36	7.7	COL4A4, COL4A3, COL4A6, COL9A2, COL4A5, GNRH1
33	ILK Signaling36	7.6	COL4A4, COL4A3, COL4A6, COL9A2, COL4A5, GNRH1
34	ERK Signaling36	7.6	COL4A4, COL4A3, COL4A6, COL9A2, COL4A5, ESR1
35	Rho Family GTPases36	7.2	DES, COL4A4, COL4A3, COL4A6, COL9A2, COL4A5

Compounds related to leiomyomatosis according to GeneDecks:

(show top 50)    (show all 74)

id	Compound	Score	Top Affiliating Genes
1	Ethynodiol Diacetate9 9	11.3	PGR, ESR1
2	ici 16438432	10.3	PGR, ESR1
3	estradiol benzoate32	10.2	PGR, ESR1, GNRH1
4	gestrinone32	10.2	PGR, GNRH1
5	fumarate32 9 9	12.1	FH, SDHB, VHL
6	buserelin32 9 9	12.1	PGR, GNRH1, LHCGR
7	clomiphene citrate32	10.1	PGR, ESR1, GNRH1
8	toremifene32 9 9	12.0	PGR, ESR1, GNRH1
9	Allylestrenol9 9	11.0	ESR1, PGR
10	goserelin32 9 9	12.0	PGR, ESR1, GNRH1, LHCGR
11	leuprolide acetate32	10.0	PGR, ESR1, GNRH1, LHCGR
12	flutamide32 9 9	12.0	PGR, ESR1, GNRH1, LHCGR
13	raloxifene32 9 9	12.0	PGR, THBS1, ESR1, GNRH1
14	progestins32	10.0	PGR, THBS1, ESR1, GNRH1
15	tibolone32	10.0	GNRH1, ESR1, PGR
16	orcein32	10.0	VIM, ACTC1, DES
17	s 10032	9.9	DES, ACTC1, VIM
18	danazol32 9 18 9	12.9	PGR, ESR1, GNRH1
19	reticulin32	9.9	VIM, ACTC1, DES
20	mucicarmine32	9.9	DES, ACTC1, VIM
21	retinoic acid32 42 18	11.7	LAMB1, GNRH1, ESR1, PGR
22	idoxifene32	9.7	ESR1, PGR
23	5fluorouracil32	9.6	PGR, THBS1, ESR1, GNRH1, IVL, BNIP3
24	mifepristone32 42 9 9	12.6	GNRH1, ESR1, THBS1, PGR
25	procollagen32	9.4	DES, THBS1, ACTC1, ITGA5, VIM
26	dihydrotestosterone32 9 18 9	12.4	PGR, DES, ESR1, GNRH1, VIM
27	nad+32	9.4	DES, FH, INHA, SDHB
28	5-aza-2deoxycytidine32	9.4	PGR, THBS1, ESR1, BNIP3, VHL, VIM
29	dmso32	9.3	PGR, THBS1, GNRH1, SDHB, VIM
30	progestin32	9.3	PGR, DES, ESR1, GNRH1, LHCGR, VIM
31	heparan sulfate32 18	10.3	DES, THBS1, IVL, LAMB1, VIM
32	ribonucleic acid32	9.3	LHCGR, INHA, GNRH1, ACTC1, THBS1, PGR
33	hematoxylin32	9.2	DES, ACTC1, INHA, IVL, VIM
34	oxygen32 18	10.1	DES, THBS1, ACTC1, FH, IVL, LDHA
35	proline32	9.1	VIM, VHL, LHCGR, IVL, FH, DES
36	estradiol32 9 18 9	12.0	PGR, DES, ESR1, INHA, LHCGR, VIM
37	lactate32	9.0	DES, GNRH1, FH, IVL, LDHA, SDHB
38	gnrh32	9.0	PGR, ESR1, GNRH1, INHA, LHCGR, VIM
39	steroid32	8.8	PGR, DES, ACTC1, ESR1, GNRH1, INHA
40	glucose32	8.8	DES, TSC1, ACTC1, FH, LAMB1, LDHA
41	glycogen32 18	9.8	DES, TSC1, ACTC1, SDHB, VHL, VIM
42	iron32 18	9.7	DES, ACTC1, IVL, SDHB, VHL, VIM
43	cyclosporin a32 42	9.7	PGR, THBS1, ACTC1, COL4A3, GNRH1, IVL
44	progesterone32 42 9 18 9	12.4	PGR, DES, THBS1, ACTC1, ESR1, GNRH1
45	testosterone32 9 18 9	11.2	PGR, DES, THBS1, ACTC1, ESR1, GNRH1
46	paraffin32	8.0	PGR, DES, THBS1, TSC1, ACTC1, ESR1
47	alanine32	8.0	PGR, THBS1, TSC1, GNRH1, INHA, LHCGR
48	estrogen32	7.8	ESR1, ACTC1, THBS1, DES, PGR, GNRH1
49	tyrosine32	7.7	ACTC1, TSC1, THBS1, DES, FH, INHA
50	vegf32	6.6	VIM, PGR, DES, THBS1, TSC1, ACTC1

Cellular components related to leiomyomatosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	collagen type IV	GO:005587	8.8	COL4A5, COL4A6, COL4A3, COL4A4
2	endoplasmic reticulum lumen	GO:005788	8.2	COL4A4, COL4A3, COL4A6, COL9A2, COL4A5
3	extracellular region	GO:005576	7.2	COL4A4, COL4A3, COL4A6, COL9A2, COL4A5, GNRH1

Biological processes related to leiomyomatosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	muscle filament sliding	GO:030049	9.2	DES, ACTC1, VIM
2	induction of apoptosis	GO:006917	8.8	BNIP3, INHA, COL4A3, THBS1
3	extracellular matrix organization	GO:030198	8.5	COL4A5, COL9A2, COL4A6, COL4A3, COL4A4
4	axon guidance	GO:007411	7.8	COL4A4, COL4A3, COL9A2, COL4A5, ITGA5, LAMB1

Molecular functions related to leiomyomatosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	integrin binding	GO:005178	9.5	LAMB1, ITGA5, THBS1
2	extracellular matrix structural constituent	GO:005201	8.2	LAMB1, COL4A5, COL4A6, COL4A3, COL4A4