Aliases & Classifications for Leiomyomatosis

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Aliases & Descriptions for Leiomyomatosis:

Name: Leiomyomatosis 10 47 12 36 65
 
Leiomyomatosis, No Icd-O Subtype 10

Classifications:



External Ids:

Disease Ontology10 DOID:5138
MeSH36 D018231
SNOMED-CT59 189789002, 75210008
NCIt42 C3748
UMLS65 C0206654

Summaries for Leiomyomatosis

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Wikipedia:68 A leiomyoma (plural leiomyomas or leiomyomata) (leio- + myo- + -oma, \"smooth-muscle tumor\") is a... more...

MalaCards based summary: Leiomyomatosis, also known as leiomyomatosis, no icd-o subtype, is related to leiomyomatosis and renal cell cancer and leiomyoma. An important gene associated with Leiomyomatosis is FH (Fumarate Hydratase), and among its related pathways are NCAM1 interactions and AGE-RAGE signaling pathway in diabetic complications. Affiliated tissues include smooth muscle, uterus and thyroid, and related mouse phenotypes are renal/urinary system and normal.

Related Diseases for Leiomyomatosis

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Diseases related to Leiomyomatosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 449)
idRelated DiseaseScoreTop Affiliating Genes
1leiomyomatosis and renal cell cancer34.1FH, LDHA, SDHB
2leiomyoma29.6ESR1, PGR
3disseminated peritoneal leiomyomatosis12.5
4intravenous leiomyomatosis12.5
5leiomyomatosis, esophageal and vulval, with nephropathy12.4
6diffuse peritoneal leiomyomatosis12.3
7uterus intravascular leiomyomatosis12.3
8uterine corpus leiomyomatosis12.3
9uterine corpus diffuse leiomyomatosis12.3
10leiomyomatosis of esophagus, cataract and hematuria12.2
11x-linked diffuse leiomyomatosis-alport syndrome12.2
12leiomyoma of vulva and esophagus11.4
13multiple cutaneous and uterine leiomyomas11.4
14autosomal dominant striatal neurodegeneration10.4COL4A5, COL4A6
15prostatitis10.4
16ataxia with vitamin e deficiency10.3COL4A4, COL4A5
17renal cell carcinoma, papillary10.3
18alport syndrome10.3
19hematuria, benign familial10.3COL4A4, COL4A5
20familial stomach cancer10.3FH, SDHB
21alport syndrome, autosomal recessive10.3COL4A4, COL4A5
22basilar migraine10.3COL4A4, COL4A5
23hypersensitivity vasculitis10.3COL4A4, COL4A5
24prostate cancer10.3
25breast cancer10.3
26thyroiditis10.3
27adenocarcinoma10.2
28syringoma10.2ESR1, PGR
29endocrine organ benign neoplasm10.2ESR1, PGR
30cervical benign neoplasm10.2ESR1, PGR
31large bowel leiomyoma10.2ESR1, PGR
32bile duct cystadenoma10.2ESR1, PGR
33glaucoma iridogoniodysgenesia10.2ESR1, PGR
34venous tributary occlusion of retina10.2ESR1, PGR
35deafness, autosomal dominant 8/1210.2ESR1, PGR
36hepatitis10.2
37leukemia10.2
38lymphoma10.2
39pancreatitis10.2
40endotheliitis10.2
41peroneal nerve paralysis10.2ESR1, PGR
42situs inversus10.2ESR1, PGR
43vulvar squamous papilloma10.2ESR1, PGR
44heritable pulmonary arterial hypertension10.2FH, SDHB
45childhood choriocarcinoma of the ovary10.2ESR1, PGR
46extragonadal nonseminomatous germ cell tumor10.2ESR1, PGR
47esophageal adenoid cystic carcinoma10.2ESR1, PGR
48ureter adenocarcinoma10.2ESR1, PGR
49dental pulp calcification10.2ESR1, PGR
50spondylitis10.2ESR1, PGR

Graphical network of the top 20 diseases related to Leiomyomatosis:



Diseases related to leiomyomatosis

Symptoms for Leiomyomatosis

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Drugs & Therapeutics for Leiomyomatosis

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Drugs for Leiomyomatosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Phase 4
2
Bevacizumabapproved, investigationalPhase 21875216974-75-3
Synonyms:
216974-75-3
Avastin
Avastin (TN)
Bevacizumab
Bevacizumab (genetical recombination)
 
Bevacizumab (genetical recombination) (JAN)
D06409
R-435
anti-VEGF monoclonal antibody
antiVEGF
bevacizumab
3
MetforminapprovedPhase 1, Phase 21645657-24-9, 1115-70-414219, 4091
Synonyms:
1,1-Dimethyl biguanide
1,1-Dimethylbiguanide
3-(diaminomethylidene)-1,1-dimethylguanidine
657-24-9
AC1L1HE4
AKOS000121065
Apo-Metformin
BIDD:GT0697
BPBio1_000009
BRD-K79602928-003-04-1
BSPBio_000007
BSPBio_002314
C07151
C4H11N5
CAS-1115-70-4
CCRIS 9321
CHEBI:6801
CHEMBL1431
CID4091
D04966
DB00331
DMBG
DMGG
Diabefagos
Diabetosan
Diabex
Diaformin
Dianben
Dimethylbiguanid
Dimethylbiguanide
Dimethylbiguanidine
Dimethyldiguanide
Dimethylguanylguanidine
EINECS 211-517-8
Fluamine
Flumamine
Fortamet
Gen-Metformin
Glifage
Gliguanid
Glucophage
Glucophage XR
Glumetza
Glycon
HMS2089D19
HSCI1_000295
Haurymelin
Haurymellin
Islotin
KBio2_002310
KBio2_004878
KBio2_007446
KBio3_002790
KBioGR_002310
 
KBioSS_002312
LA-6023
LS-43899
Meguan
Melbin
Metformin
Metformin (USAN/INN)
Metformin HCL
Metformin Hydrochloride
Metformin [USAN:INN:BAN]
Metformina
Metformina [DCIT]
Metformina [Spanish]
Metformine
Metformine [INN-French]
Metformine pamoate
Metforminum
Metforminum [INN-Latin]
Metiguanide
MolPort-002-929-560
MolPort-004-288-389
MolPort-005-767-418
Mylan-Metformin
N,N-Dimethylbiguanide
N,N-Dimethyldiguanide
N,N-Dimethylimidodicarbonimidic diamide
N,N-dimethylimidodicarbonimidic diamide
N1,N1-Dimethylbiguanide
NCGC00016564-01
NCGC00016564-02
NCGC00016564-03
NNDG
Novo-Metformin
Nu-Metformin
Obimet
PMS-Metformin
Prestwick0_000004
Prestwick1_000004
Prestwick2_000004
Prestwick3_000004
Ran-Metformin
Ratio-Metformin
Riomet
S2483_Selleck
SPBio_001928
STK011633
Sandoz Metformin
Siofor
T5895664
Teva-Metformin
UNII-9100L32L2N
ZINC12859773
cMAP_000016
metformin
metformin hydrochloride
4
AcetylcholineexperimentalPhase 268951-84-3187
Synonyms:
ACh
Acetyl choline ion
Acetylcholine Chloride
Acetylcholine cation
 
Acetylcholinium: acetyl-Choline
Choline acetate
Choline acetate (ester)
Miochol E
O-Acetylcholine
acetylcholine chloride
5Neurotransmitter AgentsPhase 214795
6Peripheral Nervous System AgentsPhase 218510
7Neuromuscular AgentsPhase 2922
8OnabotulinumtoxinAPhase 2588
9AbobotulinumtoxinAPhase 2588
10IncobotulinumtoxinAPhase 2599
11Botulinum ToxinsPhase 2616
12Botulinum Toxins, Type APhase 2588
13Cholinergic AgentsPhase 23243
14Hypoglycemic AgentsPhase 1, Phase 24503
15Protein Kinase InhibitorsPhase 23162
16
Erlotinib HydrochloridePhase 2781183319-69-9176871
Synonyms:
 
erlotinib hydrochloride
17Angiogenesis InhibitorsPhase 23688
18Angiogenesis Modulating AgentsPhase 23611
19
Progesteroneapproved50057-83-05994
Synonyms:
(S)-4-Pregnene-3,20-dione
(S)-Pregn-4-en-3,20-dione
(S)-Progesterone
.beta.-Progesterone
.delta.(sup4)-Pregnene-3,20-dione
.delta.4-Pregnene-3,20-dione
17.alpha.-Progesterone
17a-Progesterone
17alpha-Progesterone
17alpha-progesterone
17α-progesterone
1dbb
1h60
257630-50-5
3,20-Pregnene-4
32104FB6-BF81-4F6E-83C2-024DEEAEB272
4-Pregnen-3,20-dione
4-Pregnene-3,20-dione
46665_FLUKA
46665_RIEDEL
57-83-0
753497-20-0
8012-32-6
8023-13-0
AC-700
AC1L1LKF
AI3-51682
Agolutin
Akrolutin
BB_NC-0185
BHR-100
BIDD:ER0547
BIDD:PXR0094
BPBio1_000676
BRD-K64994968-001-03-6
BSPBio_000614
Bio-luton
C00410
CCRIS 533
CHEBI:17026
CHEMBL103
CID5994
CIDR
CMC_13406
COL-1620
CPD000058345
Colprosterone
Corlutin
Corlutina
Corluvite
Corporin
Corpus Luteum Hormone
Corpus luteum hormone
Crinone
Crinone (TN)
Crinone progesterone gel
Curretab
Cyclogest
Cyclogesterin
D00066
D4-Pregnene-3,20-dione
DB00396
DR-2011
Delalutin
Delta(4)-pregnene-3,20-dione
Duraprogen
EINECS 200-350-6
ETI-411
EU-0100895
Endometrin
Estima
FE-999913
Flavolutan
Fologenon
Gelbkoerperhormon
Gesterol
Gesterol 100
Gesterol 50
Gestiron
Gestone
Gestormone
Gestron
Glanducorpin
Gynlutin
Gynoluton
Gynolutone
HMS1569O16
HMS2051O05
HMS2090J07
HSDB 3389
Hormoflaveine
Hormoluton
Hydroxyprogesterone Caproate
Hydroxyprogesterone Caproic acid
LMST02030159
LS-234
Lingusorbs
Lipo-Lutin
Lipolutin
Lopac0_000895
Lucorteum
Lucorteum Sol
Lucorteum sol
Lugesteron
Luteal hormone
Luteinique
Luteocrin normale
Luteodyn
Luteogan
Luteohormone
Luteol
Luteol (VAN)
Luteopur
Luteosan
Luteostab
Luteovis
Luteum
Lutex
Lutidon
Lutin
Lutinus
Lutociclina
Lutocuclin M
Lutocyclin
Lutocyclin M
 
Lutocyclin m
Lutocylin
Lutocylol
Lutoform
Lutogyl
Lutogynon
Lutren
Lutromone
MLS000028517
MLS000758277
MLS001074187
MLS002222367
MPA
Membrettes
Methylpregnone
Micronized Progesterone
MolPort-001-794-643
NCGC00022185-03
NCGC00022185-04
NCGC00022185-05
NCGC00022185-06
NCGC00022185-07
NCGC00022185-08
NCGC00022185-09
NCGC00090798-01
NCGC00090798-02
NCI60_042166
NSC 64377
NSC 9704
NSC-9704
NSC64377
NSC9704
Nalutron
Natural Progesterone
P 0130
P0130_SIGMA
P0478
P3972_SIGMA
P6149_SIGMA
P7556_ALDRICH
P7556_SIGMA
P8783_SIGMA
P9776_SIGMA
PROGESTERONE
Percutacrine
Percutacrine Luteinique
Piaponon
Pranone
Pregn-4-en-3,20-dione
Pregn-4-ene-3,20-dione
Pregnene-3,20-dione
Pregnenedione
Prestwick0_000477
Prestwick1_000477
Prestwick2_000477
Prestwick3_000477
Prestwick_411
Primolut
Prochieve
Progeffik
Progekan
Progestan
Progestasert
Progesterol
Progesteron
Progesterona
Progesterona [INN-Spanish]
Progesterone
Progesterone (JP15/USP/INN)
Progesterone [INN:BAN:JAN]
Progesterone [Progestins]
Progesterone, water-soluble
Progesterone-Water Soluble
Progesterone: HBC complex
Progesteronum
Progesteronum [INN-Latin]
Progestin
Progestogel
Progestol
Progeston
Progestone
Progestosol
Progestrel
Progestron
Progestronol
Progestérone
Projestaject
Prolets
Prolidon
Prolutin
Proluton
Prolutone
Prometrium
Prometrium (TN)
Prontogest
Protormone
S00293
S1705_Selleck
SAM001247039
SMR000058345
SMR000653542
SPBio_002553
SR-01000000088
SR-01000000088-5
Spectrum5_002053
Syngesterone
Syngestrets
Synovex S
Syntolutan
U 3672
UNII-4G7DS2Q64Y
Utrogest
Utrogestan
Vitarrine
WLN: L E5 B666 OV MUTJ A1 E1 FV1
ZINC04428529
beta-Progesterone
bmse000482
component of Cyclogesterin
corpus luteum hormone
delta(4)-Pregnene-3,20-dione
delta(Sup 4)-Pregnene-3,20-dione
delta(Sup4)-pregnene-3,20-dione
delta(sup 4)-Pregnene-3,20-dione
delta4-Pregnene-3,20-dione
luteohormone
nchembio.2007.53-comp14

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Prospective Study Comparing Contour SE™ Microspheres to Embosphere® Microspheres for Treating Symptomatic Uterine Fibroids With Uterine Fibroid Embolization (UFE)CompletedNCT00628901Phase 4
2Randomized Pilot Study for the Treatment of Cutaneous Leiomyomas With Botulinum ToxinCompletedNCT00971620Phase 2
3A Phase II Study of Bevacizumab and Erlotinib in Subjects With Advanced Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC) or Sporadic Papillary Renal Cell CancerRecruitingNCT01130519Phase 2
4Vandetanib in Combination With Metformin in People With HLRCC or SDH-Associated Kidney Cancer or Sporadic Papillary Renal Cell CarcinomaRecruitingNCT02495103Phase 1, Phase 2
5Comparison Study in the Treatment of Uterine Fibroids Uterine Fibroid Embolization Using BeadBlock™ Embolic AgentCompletedNCT00361036Phase 1
6Surgery for Intravenous LeiomyomatosisCompletedNCT01707862
7Official Record of Patients Diagnosed With Lymphangioleiomyomatosis (LAM)CompletedNCT00001869
8Establishment of Fibroid Tissue BankCompletedNCT00710346
9Hereditary Leiomyomatosis Renal Cell Cancer - Study of the Genetic Cause and the Predisposition to Renal CancerRecruitingNCT00050752

Search NIH Clinical Center for Leiomyomatosis


Cochrane evidence based reviews: leiomyomatosis

Genetic Tests for Leiomyomatosis

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Anatomical Context for Leiomyomatosis

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MalaCards organs/tissues related to Leiomyomatosis:

33
Smooth muscle, Uterus, Thyroid, Breast, Liver, Kidney, Prostate

Animal Models for Leiomyomatosis or affiliated genes

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MGI Mouse Phenotypes related to Leiomyomatosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.5COL4A4, COL4A5, ESR1, FH, GNRH1
2MP:00028738.0COL4A6, ESR1, GNRH1, LDHA, MED12, PGR
3MP:00053857.4COL4A5, ESR1, LDHA, MED12, PGR, SDHB
4MP:00107686.3COL4A4, COL4A5, ESR1, FH, LDHA, MED12

Publications for Leiomyomatosis

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Articles related to Leiomyomatosis:

(show top 50)    (show all 585)
idTitleAuthorsYear
1
Supratentorial extraventricular WHO grade III (anaplastic) ependymoma 17 years after total removal of WHO grade II ependymoma of the fourth ventricle. (27215793)
2016
2
Activin A is associated with asthma in underweight and overweight patients. (25729977)
2015
3
A Novel MGC4607/CCM2 Gene Mutation Associated with Cerebral Spinal and Cutaneous Cavernous Angiomas. (25869611)
2015
4
Heterogeneous expression and biological function of ubiquitin carboxy-terminal hydrolase-L1 in osteosarcoma. (25578779)
2015
5
Analysis of chosen polymorphisms in FoxP3 gene in children and adolescents with autoimmune thyroid diseases. (24784317)
2014
6
Rare variants of cutaneous leishmaniasis presenting as eczematous lesions. (25405136)
2014
7
Postnatal maintenance of the 5-Ht1a-Pet1 autoregulatory loop by serotonin in the raphe nuclei of the brainstem. (24972638)
2014
8
Progressive Increase of Regulatory T Cells and Decrease of CD8+ T Cells and CD8+ T Cells/Regulatory T Cells Ratio during Colorectal Cancer Development. (24255632)
2013
9
A biomechanical comparison of three spondylolysis repair techniques in a calf spine model. (23270724)
2013
10
Profoundly different prion diseases in knock-in mice carrying single PrP codon substitutions associated with human diseases. (23959875)
2013
11
Contribution of bi-allelic germline MUTYH mutations to early-onset and familial colorectal cancer and to low number of adenomatous polyps: case-series and literature review. (23007840)
2013
12
Qualitative dynamics of lowly- and highly-pathogenic avian influenza strains. (23485554)
2013
13
Measles outbreak in Burkina Faso, 2009: a case-control study to determine risk factors and estimate vaccine effectiveness. (22652399)
2012
14
Sensitivity of whole blood clotting time and activated partial thromboplastin time for factor IX: relevance to gene therapy and determination of post-transfusion elimination time of canine factor IX in hemophilia B dogs. (22482117)
2012
15
Antimicrobial photodynamic therapy in the non-surgical treatment of aggressive periodontitis: microbiological profile. (21399951)
2012
16
Mutation screening of the GUCA1B gene in patients with autosomal dominant cone and cone rod dystrophy. (21405999)
2011
17
Glucagon-like peptide-1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway. (20225248)
2010
18
Impaired NK-cell migration in WAS/XLT patients: role of Cdc42/WASp pathway in the control of chemokine-induced beta2 integrin high-affinity state. (20130240)
2010
19
Expression profiling and comparative analyses of seven midgut serine proteases from the yellow fever mosquito, Aedes aegypti. (20100490)
2010
20
Molecular prediction of disease risk and severity in a large Dutch Crohn's disease cohort. (18824555)
2009
21
Metal ion interactions in the DNA cleavage/ligation active site of human topoisomerase IIalpha. (19697956)
2009
22
Consensus guidelines for the management of radiation dermatitis and coexisting acne-like rash in patients receiving radiotherapy plus EGFR inhibitors for the treatment of squamous cell carcinoma of the head and neck. (17785763)
2008
23
Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IkappaB kinase inhibitors. (17322026)
2007
24
A large, travel-associated outbreak of legionellosis among hotel guests: utility of the urine antigen assay in confirming Pontiac fever. (17173221)
2007
25
Marmoset glutathione peroxidases: cDNA sequences, molecular evolution, and gene expression. (16764674)
2006
26
Ischemic damage increases nitric oxide production via inducible nitric oxide synthase in the cochlea. (16154689)
2005
27
Oct-1 counteracts autoinhibition of Runx2 DNA binding to form a novel Runx2/Oct-1 complex on the promoter of the mammary gland-specific gene beta-casein. (15798204)
2005
28
Characterization of human urinary bladder KATP channels containing SUR2B splice variants expressed in L-cells. (14729107)
2004
29
Sixteen cases of sclerosing hemangioma of the lung including unusual presentations. (15201499)
2004
30
Membrane expression of proteinase 3 is genetically determined. (12506139)
2003
31
18q-syndrome and ectodermal dysplasia syndrome: description of a child and his family. (12494443)
2003
32
Bilateral acute anterior uveitis after alendronate. (12446386)
2002
33
Carbachol-stimulated transactivation of epidermal growth factor receptor and mitogen-activated protein kinase in T(84) cells is mediated by intracellular ca(2+), PYK-2, and p60(src). (10777553)
2000
34
Patterns of keratin polypeptides in 110 biphasic, monophasic, and poorly differentiated synovial sarcomas. (11037348)
2000
35
The structure and function of HFE. (10878571)
2000
36
Does aflatoxin B1 play a role in the etiology of hepatocellular carcinoma in the United States? (10624703)
1999
37
Mechanical strain increases expression of the brain natriuretic peptide gene in rat cardiac myocytes. (9346958)
1997
38
Tyrosine residue in exon 14 of the cytoplasmic domain of platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) regulates ligand binding specificity. (9298995)
1997
39
Type I insulin-like growth factor receptor gene expression in normal human breast tissue treated with oestrogen and progesterone. (9010034)
1997
40
13-cis retinoic acid and interferon-alfa-2a as palliative therapy in pretreated, recurrent squamous epithelial carcinoma of the cervix uteri and vulva]. (9036064)
1996
41
Inhibition of RNA splicing at the Rous sarcoma virus src 3' splice site is mediated by an interaction between a negative cis element and a chicken embryo fibroblast nuclear factor. (7609076)
1995
42
Signal transduction by the B-cell antigen receptor. (7486656)
1995
43
Experimental and theoretical study of reversible monoamine oxidase inhibitors: structural approach of the active site of the enzyme. (7931244)
1994
44
The role of cytokines in the pathophysiology of chronic liver diseases. (8123873)
1993
45
Elderly patients with suppressed serum TSH but normal free thyroid hormone levels usually have mild thyroid overactivity and are at increased risk of developing overt hyperthyroidism. (1670067)
1991
46
Prenatal diagnosis of achondrogenesis. (2193886)
1990
47
DNA probes in X-linked disease. (6129448)
1983
48
Cardiomyopathy produced in rats with acute renal hypertension. (7354229)
1980
49
Cerebellar ganglioglioma. Case report. (479941)
1979
50

Variations for Leiomyomatosis

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Expression for genes affiliated with Leiomyomatosis

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Search GEO for disease gene expression data for Leiomyomatosis.

GO Terms for genes affiliated with Leiomyomatosis

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Cellular components related to Leiomyomatosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1perikaryonGO:004320410.0ESR1, GNRH1
2collagen type IV trimerGO:00055879.7COL4A4, COL4A5, COL4A6
3mitochondrionGO:00057398.5ESR1, FH, GNRH1, SDHB

Biological processes related to Leiomyomatosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1collagen catabolic processGO:00305749.6COL4A4, COL4A6
2transcription initiation from RNA polymerase II promoterGO:00063679.3ESR1, MED12, PGR
3extracellular matrix disassemblyGO:00226179.3COL4A4, COL4A5, COL4A6
4response to estrogenGO:00436279.2ESR1, LDHA

Sources for Leiomyomatosis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet