MCID: LMY005
MIFTS: 47

Leiomyomatosis and Renal Cell Cancer malady

Categories: Genetic diseases, Rare diseases, Nephrological diseases, Skin diseases, Cancer diseases

Aliases & Classifications for Leiomyomatosis and Renal Cell Cancer

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Aliases & Descriptions for Leiomyomatosis and Renal Cell Cancer:

Name: Leiomyomatosis and Renal Cell Cancer 49 11 23
Hereditary Leiomyomatosis and Renal Cell Cancer 21 45 22 23 51 67 65
Hlrcc 21 45 22 23 47 51 67
Multiple Cutaneous and Uterine Leiomyomata 45 23 67
Mcul 45 23 51
Lrcc 45 23 67
Mcl 45 23 67
Hereditary Leiomyomatosis and Renal Cell Carcinoma 22 23
Leiomyomatosis and Renal Cell Cancer Hereditary 67 24
Leiomyomatosis Familial 45 24
Reed's Syndrome 45 23
Multiple Cutaneous and Uterine Leiomyomata 1 with or Without Renal Cell Carcinoma 67
Hereditary Leiomyomatosis with Renal Carcinoma 51
 
Familial Leiomyomatosis and Renal Cell Cancer 51
Familial Leiomyomatosis with Renal Carcinoma 51
Multiple Cutaneous and Uterine Leiomyomas 51
Hereditary Multiple Cutaneous Leiomyomas 51
Familial Multiple Cutaneous Leiomyomas 51
Familial Leiomyomatosis Cutis Et Uteri 51
Multiple Cutaneous Leiomyomata 45
Leiomyoma Multiple Cutaneous 67
Multiple Cutaneous Leiomyoma 23
Hereditary Leiomyomatosis 51
Familial Leiomyomatosis 45
Reed Syndrome 51
Mcul1 67

Characteristics:

Orphanet epidemiological data:

51
hereditary leiomyomatosis and renal cell cancer:
Inheritance: Autosomal dominant; Age of onset: Adolescent,Adult,Elderly

HPO:

61
leiomyomatosis and renal cell cancer:
Onset and clinical course: incomplete penetrance
Inheritance: autosomal dominant inheritance


Classifications:



External Ids:

OMIM49 150800
Orphanet51 523
ICD10 via Orphanet28 D23
MeSH36 D018231
UMLS65 C1708350

Summaries for Leiomyomatosis and Renal Cell Cancer

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OMIM:49 Hereditary leiomyomatosis and renal cell cancer is an autosomal dominant tumor predisposition syndrome characterized by... (150800) more...

MalaCards based summary: Leiomyomatosis and Renal Cell Cancer, also known as hereditary leiomyomatosis and renal cell cancer, is related to multiple cutaneous and uterine leiomyomas and renal cell carcinoma, papillary, and has symptoms including neoplasm of the skin, abnormality of the musculature and pruritus. An important gene associated with Leiomyomatosis and Renal Cell Cancer is FH (Fumarate Hydratase), and among its related pathways are Citrate cycle (TCA cycle) and Pyruvate metabolism. Affiliated tissues include uterus, skin and kidney, and related mouse phenotype cardiovascular system.

Genetics Home Reference:23 Hereditary leiomyomatosis and renal cell cancer (HLRCC) is a disorder in which affected individuals tend to develop benign tumors containing smooth muscle tissue (leiomyomas) in the skin and, in females, the uterus. This condition also increases the risk of kidney cancer.

NIH Rare Diseases:45 Hereditary leiomyomatosis and renal cell cancer (hlrcc) is a condition that causes benign tumors of smooth muscle tissue in the skin (cutaneous leiomyomas) and in the uterus in females (uterine leiomyomas, or fibroids). the condition also increases the risk of kidney cancer. signs and symptoms usually begin in adulthood as skin growths appear on the torso, arms, legs, and occasionally on the face. they tend to increase in size and number over time. about 10% to 16% of people with hlrcc develop a type of kidney cancer called renal cell cancer; symptoms of this cancer may include lower back pain, blood in the urine, and/or a mass in the kidney that can be felt by a physician. some people have no symptoms until the cancer is advanced. hlrcc is caused by mutations in the fh gene and is inherited in an autosomal dominant manner. last updated: 1/9/2014

UniProtKB/Swiss-Prot:67 Hereditary leiomyomatosis and renal cell cancer: A disorder characterized by predisposition to cutaneous and uterine leiomyomas, and papillary type 2 renal cancer which occurs in about 20% of patients.

Wikipedia:68 Reed’s syndrome (or familial leiomyomatosis cutis et uteri) is a rare inherited condition... more...

GeneReviews summary for NBK1252

Related Diseases for Leiomyomatosis and Renal Cell Cancer

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Graphical network of the top 20 diseases related to Leiomyomatosis and Renal Cell Cancer:



Diseases related to leiomyomatosis and renal cell cancer

Symptoms for Leiomyomatosis and Renal Cell Cancer

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Symptoms by clinical synopsis from OMIM:

150800

Clinical features from OMIM:

150800

Symptoms:

 51 (show all 10)
  • skin tumors/lumps/epidermal cysts
  • muscle anomalies
  • autosomal dominant inheritance
  • pruritus/itching
  • cataract/lens opacification
  • megaesophagus/cardiospasm/congenital dilation of the esophagus/achalasia
  • esophageal neoplasm/tumor/carcinoma/cancer
  • uterus/uterine/cervix/endometrium neoplasm/tumor/carcinoma/cancer
  • vaginal/vulvar neoplasm/tumor/carcinoma/cancer
  • kidney/renal neoplasm/tumor/carcinoma/cancer

HPO human phenotypes related to Leiomyomatosis and Renal Cell Cancer:

(show all 14)
id Description Frequency HPO Source Accession
1 neoplasm of the skin hallmark (90%) HP:0008069
2 abnormality of the musculature hallmark (90%) HP:0003011
3 pruritus typical (50%) HP:0000989
4 esophageal neoplasm occasional (7.5%) HP:0100751
5 vaginal neoplasm occasional (7.5%) HP:0100650
6 uterine neoplasm occasional (7.5%) HP:0010784
7 cataract occasional (7.5%) HP:0000518
8 cutaneous leiomyosarcoma rare (5%) HP:0006755
9 cutaneous leiomyoma HP:0007620
10 multiple cutaneous leiomyomas HP:0007437
11 renal cell carcinoma HP:0005584
12 decreased fumarate hydratase activity HP:0003536
13 uterine leiomyosarcoma HP:0002891
14 uterine leiomyoma HP:0000131

Drugs & Therapeutics for Leiomyomatosis and Renal Cell Cancer

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Drugs for Leiomyomatosis and Renal Cell Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Bevacizumabapproved, investigationalPhase 21875216974-75-3
Synonyms:
216974-75-3
Avastin
Avastin (TN)
Bevacizumab
Bevacizumab (genetical recombination)
 
Bevacizumab (genetical recombination) (JAN)
D06409
R-435
anti-VEGF monoclonal antibody
antiVEGF
bevacizumab
2
MetforminapprovedPhase 1, Phase 21645657-24-9, 1115-70-414219, 4091
Synonyms:
1,1-Dimethyl biguanide
1,1-Dimethylbiguanide
3-(diaminomethylidene)-1,1-dimethylguanidine
657-24-9
AC1L1HE4
AKOS000121065
Apo-Metformin
BIDD:GT0697
BPBio1_000009
BRD-K79602928-003-04-1
BSPBio_000007
BSPBio_002314
C07151
C4H11N5
CAS-1115-70-4
CCRIS 9321
CHEBI:6801
CHEMBL1431
CID4091
D04966
DB00331
DMBG
DMGG
Diabefagos
Diabetosan
Diabex
Diaformin
Dianben
Dimethylbiguanid
Dimethylbiguanide
Dimethylbiguanidine
Dimethyldiguanide
Dimethylguanylguanidine
EINECS 211-517-8
Fluamine
Flumamine
Fortamet
Gen-Metformin
Glifage
Gliguanid
Glucophage
Glucophage XR
Glumetza
Glycon
HMS2089D19
HSCI1_000295
Haurymelin
Haurymellin
Islotin
KBio2_002310
KBio2_004878
KBio2_007446
KBio3_002790
KBioGR_002310
 
KBioSS_002312
LA-6023
LS-43899
Meguan
Melbin
Metformin
Metformin (USAN/INN)
Metformin HCL
Metformin Hydrochloride
Metformin [USAN:INN:BAN]
Metformina
Metformina [DCIT]
Metformina [Spanish]
Metformine
Metformine [INN-French]
Metformine pamoate
Metforminum
Metforminum [INN-Latin]
Metiguanide
MolPort-002-929-560
MolPort-004-288-389
MolPort-005-767-418
Mylan-Metformin
N,N-Dimethylbiguanide
N,N-Dimethyldiguanide
N,N-Dimethylimidodicarbonimidic diamide
N,N-dimethylimidodicarbonimidic diamide
N1,N1-Dimethylbiguanide
NCGC00016564-01
NCGC00016564-02
NCGC00016564-03
NNDG
Novo-Metformin
Nu-Metformin
Obimet
PMS-Metformin
Prestwick0_000004
Prestwick1_000004
Prestwick2_000004
Prestwick3_000004
Ran-Metformin
Ratio-Metformin
Riomet
S2483_Selleck
SPBio_001928
STK011633
Sandoz Metformin
Siofor
T5895664
Teva-Metformin
UNII-9100L32L2N
ZINC12859773
cMAP_000016
metformin
metformin hydrochloride
3
AcetylcholineexperimentalPhase 268951-84-3187
Synonyms:
ACh
Acetyl choline ion
Acetylcholine Chloride
Acetylcholine cation
 
Acetylcholinium: acetyl-Choline
Choline acetate
Choline acetate (ester)
Miochol E
O-Acetylcholine
acetylcholine chloride
4AbobotulinumtoxinAPhase 2588
5Peripheral Nervous System AgentsPhase 218510
6Neurotransmitter AgentsPhase 214795
7OnabotulinumtoxinAPhase 2588
8Botulinum Toxins, Type APhase 2588
9Neuromuscular AgentsPhase 2922
10Botulinum ToxinsPhase 2616
11IncobotulinumtoxinAPhase 2599
12Cholinergic AgentsPhase 23243
13Hypoglycemic AgentsPhase 1, Phase 24503
14Protein Kinase InhibitorsPhase 23162
15Angiogenesis Modulating AgentsPhase 23611
16Angiogenesis InhibitorsPhase 23688
17
Erlotinib HydrochloridePhase 2781183319-69-9176871
Synonyms:
 
erlotinib hydrochloride

Interventional clinical trials:

idNameStatusNCT IDPhase
1Randomized Pilot Study for the Treatment of Cutaneous Leiomyomas With Botulinum ToxinCompletedNCT00971620Phase 2
2A Phase II Study of Bevacizumab and Erlotinib in Subjects With Advanced Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC) or Sporadic Papillary Renal Cell CancerRecruitingNCT01130519Phase 2
3Vandetanib in Combination With Metformin in People With HLRCC or SDH-Associated Kidney Cancer or Sporadic Papillary Renal Cell CarcinomaRecruitingNCT02495103Phase 1, Phase 2
4Hereditary Leiomyomatosis Renal Cell Cancer - Study of the Genetic Cause and the Predisposition to Renal CancerRecruitingNCT00050752

Search NIH Clinical Center for Leiomyomatosis and Renal Cell Cancer

Genetic Tests for Leiomyomatosis and Renal Cell Cancer

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Genetic tests related to Leiomyomatosis and Renal Cell Cancer:

id Genetic test Affiliating Genes
1 Hereditary Leiomyomatosis and Renal Cell Cancer22 FH

Anatomical Context for Leiomyomatosis and Renal Cell Cancer

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MalaCards organs/tissues related to Leiomyomatosis and Renal Cell Cancer:

33
Uterus, Skin, Kidney, Smooth muscle, Cervix, Brain, Pituitary

Animal Models for Leiomyomatosis and Renal Cell Cancer or affiliated genes

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MGI Mouse Phenotypes related to Leiomyomatosis and Renal Cell Cancer:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.0BNIP3, HIF1A, LDHA, SDHB

Publications for Leiomyomatosis and Renal Cell Cancer

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Articles related to Leiomyomatosis and Renal Cell Cancer:

(show all 37)
idTitleAuthorsYear
1
Triggering Events and New Daily Persistent Headache: Age and Gender Differences and Insights on Pathogenesis-A Clinic-Based Study. (26474179)
2015
2
Postnatal maintenance of the 5-Ht1a-Pet1 autoregulatory loop by serotonin in the raphe nuclei of the brainstem. (24972638)
2014
3
Expression of cancer stem cell markers is more frequent in anaplastic thyroid carcinoma compared to papillary thyroid carcinoma and is related to adverse clinical outcome. (23986551)
2014
4
Intussusception incidence rates in 9 zambian hospitals, 2007-2011: prerotavirus vaccine introduction. (24343623)
2014
5
Early cisplatin induced ototoxicity profile may predict the need for hearing support in children with medulloblastoma. (23002030)
2013
6
Surgery for varicose veins: use of tourniquet. (23749738)
2013
7
The Air Quality Health Index as a predictor of emergency department visits for ischemic stroke in Edmonton, Canada. (24301354)
2013
8
The value of mucosal allergen challenge for the diagnosis of food allergy. (23571410)
2013
9
Molecular and functional studies of 4 candidate loci in Pendred syndrome and nonsyndromic hearing loss. (22285650)
2012
10
Metabolically regulated endoplasmic reticulum-associated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase: evidence for requirement of a geranylgeranylated protein. (21778231)
2011
11
Two- and three-dimensional prenatal sonographic diagnosis of prune-belly syndrome. (20014136)
2010
12
A new isoquinolinium derivative, Cadein1, preferentially induces apoptosis in p53-defective cancer cells with functional mismatch repair via a p38-dependent pathway. (19948725)
2010
13
Molecular prediction of disease risk and severity in a large Dutch Crohn's disease cohort. (18824555)
2009
14
Polymorphisms in mannan-binding lectin (MBL)-associated serine protease 2 affect stability, binding to MBL, and enzymatic activity. (19234189)
2009
15
SPINK9: a selective, skin-specific Kazal-type serine protease inhibitor. (19194479)
2009
16
Mediastinal lymphangiomatosis. (19670583)
2009
17
Clusterin expression in non-neoplastic adenohypophyses and pituitary adenomas: cytoplasmic clusterin localization in adenohypophysis is related to aging. (18239862)
2008
18
Prostacyclin induction by high-density lipoprotein (HDL) in vascular smooth muscle cells depends on sphingosine 1-phosphate receptors: effect of simvastatin. (18612546)
2008
19
Long-term therapy with endothelin-1 antagonist for pulmonary hypertension secondary to systemic sclerosis]. (18686806)
2008
20
Bilateral Candida chorioretinitis following etanercept treatment for hidradenitis suppurativa. (18239677)
2008
21
RNA interference for subacute sclerosing panencephalitis. (17419079)
2007
22
Flavivirus activation of plasmacytoid dendritic cells delineates key elements of TLR7 signaling beyond endosomal recognition. (17082628)
2006
23
Haplotypes in the urotensin II gene and urotensin II receptor gene are associated with insulin resistance and impaired glucose tolerance. (16597476)
2006
24
The neurobiology of the tuberous sclerosis complex. (17028374)
2006
25
Oral pyogenic granuloma: a review. (17220613)
2006
26
NO (nitric oxide) and its significance in regulation of vascular homeostasis]. (12793052)
2003
27
Pharmacologic mitogen-activated protein/extracellular signal-regulated kinase kinase/mitogen-activated protein kinase inhibitors interact synergistically with STI571 to induce apoptosis in Bcr/Abl-expressing human leukemia cells. (11782377)
2002
28
Sequence-specific 1H, 13C and 15N resonance assignments of human GABA receptor associated protein. (11727985)
2001
29
Inositol hexakisphosphate increases L-type Ca2+ channel activity by stimulation of adenylyl cyclase. (11481223)
2001
30
Organophosphate neuropathy due to methamidophos: biochemical and neurophysiological markers. (10447555)
1999
31
Both inducible and constitutive activator protein-1-like transcription factors are used for transcriptional activation of the galanin gene by different first and second messenger pathways. (10385697)
1999
32
Branchio-oto-renal syndrome. (9777487)
1998
33
Mechanical strain increases expression of the brain natriuretic peptide gene in rat cardiac myocytes. (9346958)
1997
34
Structural basis for pleckstrin homology domain mutations in X-linked agammaglobulinemia. (7849006)
1995
35
Acylcarnitine profile in tissues and body fluids of biotin-deficient rats with and without L-carnitine supplementation. (7707691)
1994
36
Prosopagnosia and agnosia for noncanonical views. An autopsied case. (3208058)
1988
37
Lymphoproliferative lesion in congenital thymic aplasia associated with agammaglobulinemia. (4390934)
1969

Variations for Leiomyomatosis and Renal Cell Cancer

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UniProtKB/Swiss-Prot genetic disease variations for Leiomyomatosis and Renal Cell Cancer:

67
id Symbol AA change Variation ID SNP ID
1FHp.Lys230ArgVAR_002445
2FHp.Asn107ThrVAR_013497
3FHp.Ala117ProVAR_013498
4FHp.His180ArgVAR_013499
5FHp.Gln185ArgVAR_013500
6FHp.Arg233HisVAR_013501rs28933069
7FHp.Gly282ValVAR_013502
8FHp.Met328ArgVAR_013503

Clinvar genetic disease variations for Leiomyomatosis and Renal Cell Cancer:

5 (show all 13)
id Gene Variation Type Significance SNP ID Assembly Location
1FHNM_000143.3(FH): c.697C> T (p.Arg233Cys)single nucleotide variantPathogenicrs587781682GRCh37Chr 1, 241671944: 241671944
2FHNM_000143.3(FH): c.301C> T (p.Arg101Ter)single nucleotide variantPathogenicrs121913120GRCh37Chr 1, 241676980: 241676980
3FHNM_000143.3(FH): c.671_672delAG (p.Glu224Valfs)deletionPathogenicrs780001199GRCh37Chr 1, 241671969: 241671970
4FHNM_000143.3(FH): c.1027C> T (p.Arg343Ter)single nucleotide variantPathogenicrs121913122GRCh37Chr 1, 241667423: 241667423
5FHNM_000143.3(FH): c.698G> A (p.Arg233His)single nucleotide variantPathogenicrs121913123GRCh37Chr 1, 241671943: 241671943
6FHNM_000143.3(FH): c.698G> T (p.Arg233Leu)single nucleotide variantPathogenicrs121913123GRCh37Chr 1, 241671943: 241671943
7FHNM_000143.3(FH): c.302G> C (p.Arg101Pro)single nucleotide variantPathogenicrs75086406GRCh37Chr 1, 241676979: 241676979
8FHNM_000143.3(FH): c.1067T> A (p.Leu356Ter)single nucleotide variantLikely pathogenic, Pathogenicrs727503927GRCh38Chr 1, 241504083: 241504083
9FHNM_000143.3(FH): c.556-1G> Csingle nucleotide variantPathogenicrs794727698GRCh37Chr 1, 241672086: 241672086
10FHNM_000143.3(FH): c.912_918delTTTTGTC (p.Phe305Leufs)deletionPathogenicrs794727836GRCh37Chr 1, 241667532: 241667538
11FHNM_000143.3(FH): c.905-1G> Asingle nucleotide variantPathogenicrs797044973GRCh37Chr 1, 241667546: 241667546
12FHNM_000143.3(FH): c.1210G> T (p.Glu404Ter)single nucleotide variantPathogenicrs797044974GRCh38Chr 1, 241502469: 241502469
13FHNM_000143.3(FH): c.320A> C (p.Asn107Thr)single nucleotide variantPathogenicrs121913121GRCh37Chr 1, 241676961: 241676961

Cosmic variations for Leiomyomatosis and Renal Cell Cancer:

7 (show top 50)    (show all 506)
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
1COSM44225TP53skin,arm,carcinoma,NS3
2COSM44225TP53skin,arm,carcinoma,NS3
3COSM44227TP53skin,face,carcinoma,NS3
4COSM44097TP53skin,face,carcinoma,NS3
5COSM44097TP53skin,face,carcinoma,NS3
6COSM44097TP53skin,face,carcinoma,NS3
7COSM44097TP53skin,face,carcinoma,NS3
8COSM44227TP53skin,face,carcinoma,NS3
9COSM44241TP53skin,face,carcinoma,NS3
10COSM44398TP53skin,lower leg,carcinoma,NS3
11COSM44435TP53skin,face,carcinoma,NS3
12COSM44435TP53skin,face,carcinoma,NS3
13COSM44398TP53skin,lower leg,carcinoma,NS3
14COSM44295TP53skin,face,carcinoma,NS3
15COSM44241TP53skin,face,carcinoma,NS3
16COSM44295TP53skin,face,carcinoma,NS3
17COSM43920TP53skin,face,carcinoma,NS3
18COSM43920TP53skin,face,carcinoma,NS3
19COSM43596TP53skin,face,carcinoma,NS3
20COSM43596TP53skin,face,carcinoma,NS3
21COSM43665TP53skin,face,carcinoma,NS3
22COSM43588TP53skin,face,carcinoma,NS3
23COSM43588TP53skin,face,carcinoma,NS3
24COSM10654TP53skin,face,carcinoma,NS3
25COSM43582TP53skin,face,carcinoma,NS3
26COSM43665TP53skin,face,carcinoma,NS3
27COSM43697TP53kidney,NS,carcinoma,papillary renal cell carcinoma3
28COSM43742TP53skin,face,carcinoma,NS3
29COSM43742TP53skin,face,carcinoma,NS3
30COSM43700TP53skin,face,carcinoma,NS3
31COSM43700TP53skin,face,carcinoma,NS3
32COSM43697TP53kidney,NS,carcinoma,papillary renal cell carcinoma3
33COSM43697TP53kidney,NS,carcinoma,papillary renal cell carcinoma3
34COSM44552TP53skin,face,carcinoma,NS3
35COSM44552TP53skin,face,carcinoma,NS3
36COSM10705TP53skin,face,carcinoma,NS3
37COSM10992TP53skin,face,carcinoma,NS3
38COSM10992TP53skin,face,carcinoma,NS3
39COSM10705TP53skin,face,carcinoma,NS3
40COSM10705TP53skin,face,carcinoma,NS3
41COSM10705TP53skin,face,carcinoma,NS3
42COSM10705TP53skin,face,carcinoma,NS3
43COSM44436TP53skin,face,carcinoma,NS3
44COSM44436TP53skin,face,carcinoma,NS3
45COSM10863TP53skin,lower leg,carcinoma,squamous cell carcinoma BRAF inhibitor related3
46COSM45114TP53skin,lower leg,carcinoma,squamous cell carcinoma BRAF inhibitor related3
47COSM45765TP53skin,lower leg,carcinoma,squamous cell carcinoma BRAF inhibitor related3
48COSM44068TP53skin,face,carcinoma,NS3
49COSM44068TP53skin,face,carcinoma,NS3
50COSM11449TP53skin,face,carcinoma,NS3

Expression for genes affiliated with Leiomyomatosis and Renal Cell Cancer

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Search GEO for disease gene expression data for Leiomyomatosis and Renal Cell Cancer.

Pathways for genes affiliated with Leiomyomatosis and Renal Cell Cancer

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GO Terms for genes affiliated with Leiomyomatosis and Renal Cell Cancer

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Biological processes related to Leiomyomatosis and Renal Cell Cancer according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1lactate metabolic processGO:00060899.5HIF1A, LDHA
2positive regulation of macroautophagyGO:00162399.5BNIP3, HIF1A
3cellular response to cobalt ionGO:00712799.5BNIP3, HIF1A
4negative regulation of reactive oxygen species metabolic processGO:20003789.4BNIP3, HIF1A
5positive regulation of autophagyGO:00105089.3BNIP3, HIF1A
6response to glucoseGO:00097499.2HIF1A, LDHA
7cellular response to hypoxiaGO:00714569.1BNIP3, HIF1A
8cellular response to mechanical stimulusGO:00712609.0BNIP3, HIF1A
9response to estrogenGO:00436278.7HIF1A, LDHA

Molecular functions related to Leiomyomatosis and Renal Cell Cancer according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:00428029.3BNIP3, LDHA
2oxidoreductase activityGO:00164919.0LDHA, SDHB

Sources for Leiomyomatosis and Renal Cell Cancer

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet