MCID: LMY005
MIFTS: 58

Leiomyomatosis and Renal Cell Cancer malady

Genetic diseases, Rare diseases, Nephrological diseases, Skin diseases, Cancer diseases categories

Summaries for Leiomyomatosis and Renal Cell Cancer

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OMIM:47 Hereditary leiomyomatosis and renal cell cancer is an autosomal dominant tumor predisposition syndrome characterized by... (150800) more...

MalaCards based summary: Leiomyomatosis and Renal Cell Cancer, also known as hereditary leiomyomatosis and renal cell cancer, is related to uterine fibroid and leiomyomatosis, and has symptoms including abnormality of the musculature, neoplasm of the skin and pruritus. An important gene associated with Leiomyomatosis and Renal Cell Cancer is FH (fumarate hydratase), and among its related pathways are Glucose / Energy Metabolism and Citric acid cycle (TCA cycle). The compounds 5-aza-2deoxycytidine and 5fluorouracil have been mentioned in the context of this disorder. Affiliated tissues include uterus, skin and kidney, and related mouse phenotype homeostasis/metabolism.

Genetics Home Reference:23 Hereditary leiomyomatosis and renal cell cancer (HLRCC) is a disorder in which affected individuals tend to develop benign tumors containing smooth muscle tissue (leiomyomas) in the skin and, in females, the uterus. This condition also increases the risk of kidney cancer.

NIH Rare Diseases:43 Hereditary leiomyomatosis and renal cell cancer (hlrcc) is a condition that causes benign tumors of smooth muscle tissue in the skin (cutaneous leiomyomas) and in the uterus in females (uterine leiomyomas, or fibroids). the condition also increases the risk of kidney cancer. signs and symptoms usually begin in adulthood as skin growths appear on the torso, arms, legs, and occasionally on the face. they tend to increase in size and number over time. about 10% to 16% of people with hlrcc develop a type of kidney cancer called renal cell cancer; symptoms of this cancer may include lower back pain, blood in the urine, and/or a mass in the kidney that can be felt by a physician. some people have no symptoms until the cancer is advanced. hlrcc is caused by mutations in the fh gene and is inherited in an autosomal dominant manner. last updated: 1/9/2014

Wikipedia:65 Reed?s syndrome (or familial leiomyomatosis cutis et uteri) is a rare inherited condition characterised... more...

GeneReviews summary for hlrcc

Aliases & Classifications for Leiomyomatosis and Renal Cell Cancer

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Sources:
47OMIM, 11diseasecard, 23Genetics Home Reference, 21GeneReviews, 43NIH Rare Diseases, 49Orphanet, 45Novoseek, 22GeneTests, 24GTR, 28ICD10 via Orphanet
See all sources

Leiomyomatosis and Renal Cell Cancer, Aliases & Descriptions:

Name: Leiomyomatosis and Renal Cell Cancer 47 11 23
Hereditary Leiomyomatosis and Renal Cell Cancer 47 21 43 23 49
Hlrcc 21 43 23 45 49
Multiple Cutaneous and Uterine Leiomyomas 43 22 49
Mcul 43 23 49
Hereditary Leiomyomatosis and Renal Cell Carcinoma 23 24
Leiomyomatosis and Renal Cell Cancer, Hereditary 43 22
Hereditary Leiomyomatosis with Renal Carcinoma 43 49
Familial Leiomyomatosis and Renal Cell Cancer 43 49
Familial Leiomyomatosis with Renal Carcinoma 43 49
Multiple Cutaneous and Uterine Leiomyomata 43 23
Hereditary Multiple Cutaneous Leiomyomas 43 49
 
Familial Multiple Cutaneous Leiomyomas 43 49
Familial Leiomyomatosis Cutis Et Uteri 43 49
Hereditary Leiomyomatosis 43 49
Leiomyomatosis Familial 43 24
Reed's Syndrome 43 23
Reed Syndrome 43 49
Lrcc 43 23
Mcl 43 23
Multiple Cutaneous Leiomyomata 43
Multiple Cutaneous Leiomyoma 23
Familial Leiomyomatosis 43


Classifications:



Characteristics (Orphanet epidemiological data):

49
hereditary leiomyomatosis and renal cell cancer:
Inheritance: Autosomal dominant; Age of onset: Adolescent,Adult,Elderly


External Ids:

OMIM47 150800
Orphanet49 523
ICD10 via Orphanet28 D23

Related Diseases for Leiomyomatosis and Renal Cell Cancer

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Diseases related to Leiomyomatosis and Renal Cell Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 19)
idRelated DiseaseScoreTop Affiliating Genes
1uterine fibroid30.5FH, THBS1
2leiomyomatosis11.1
3kidney cancer10.5
4cerebritis10.3
5renal cell carcinoma10.3
6leiomyoma10.3
7myopathy10.3
8hypoxia10.3
9male infertility10.1
10infertility10.1
11myoma10.1
12night blindness skeletal anomalies unusual facies10.1
13night blindness - skeletal anomalies - dysmorphism10.1
14fumarase deficiency10.0
15fumarate hydratase deficiency10.0
16bladder cancer, somatic10.0FH, THBS1
17malignant glioma10.0THBS1, BNIP3
18breast cancer9.9LDHA, BNIP3, THBS1
19prostate cancer9.9FH, BNIP3, THBS1

Graphical network of diseases related to Leiomyomatosis and Renal Cell Cancer:



Diseases related to leiomyomatosis and renal cell cancer

Symptoms for Leiomyomatosis and Renal Cell Cancer

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Symptoms by clinical synopsis from OMIM:

150800

Clinical features from OMIM:

150800

Symptoms:

 49 (show all 10)
  • skin tumors/lumps/epidermal cysts
  • muscle anomalies
  • autosomal dominant inheritance
  • pruritus/itching
  • cataract/lens opacification
  • megaesophagus/cardiospasm/congenital dilation of the esophagus/achalasia
  • esophageal neoplasm/tumor/carcinoma/cancer
  • uterus/uterine/cervix/endometrium neoplasm/tumor/carcinoma/cancer
  • vaginal/vulvar neoplasm/tumor/carcinoma/cancer
  • kidney/renal neoplasm/tumor/carcinoma/cancer

HPO human phenotypes related to Leiomyomatosis and Renal Cell Cancer:

(show all 16)
id Description Frequency HPO Source Accession
1 abnormality of the musculature hallmark (90%) HP:0003011
2 neoplasm of the skin hallmark (90%) HP:0008069
3 pruritus typical (50%) HP:0000989
4 cataract occasional (7.5%) HP:0000518
5 renal neoplasm occasional (7.5%) HP:0009726
6 uterine neoplasm occasional (7.5%) HP:0010784
7 vaginal neoplasm occasional (7.5%) HP:0100650
8 esophageal neoplasm occasional (7.5%) HP:0100751
9 cutaneous leiomyosarcoma rare (5%) HP:0006755
10 autosomal dominant inheritance HP:0000006
11 uterine leiomyoma HP:0000131
12 uterine leiomyosarcoma HP:0002891
13 decreased fumarate hydratase activity HP:0003536
14 incomplete penetrance HP:0003829
15 multiple cutaneous leiomyomas HP:0007437
16 cutaneous leiomyoma HP:0007620

Drugs & Therapeutics for Leiomyomatosis and Renal Cell Cancer

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Drug clinical trials:

Search ClinicalTrials for Leiomyomatosis and Renal Cell Cancer

Search NIH Clinical Center for Leiomyomatosis and Renal Cell Cancer

Genetic Tests for Leiomyomatosis and Renal Cell Cancer

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Genetic tests related to Leiomyomatosis and Renal Cell Cancer:

id Genetic test Affiliating Genes
1 Hereditary Leiomyomatosis and Renal Cell Cancer22 24 FH
2 Multiple Cutaneous and Uterine Leiomyomas22 FH
3 Leiomyomatosis Familial24

Anatomical Context for Leiomyomatosis and Renal Cell Cancer

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MalaCards organs/tissues related to Leiomyomatosis and Renal Cell Cancer:

33
Uterus, Skin, Kidney, Smooth muscle, Cervix

Animal Models for Leiomyomatosis and Renal Cell Cancer or affiliated genes

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MGI Mouse Phenotypes related to Leiomyomatosis and Renal Cell Cancer:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.0FH, LDHA, BNIP3, THBS1

Publications for Leiomyomatosis and Renal Cell Cancer

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Articles related to Leiomyomatosis and Renal Cell Cancer:

(show all 32)
idTitleAuthorsYear
1
Hereditary leiomyomatosis and renal cell cancer (HLRCC): renal cancer risk, surveillance and treatment. (25012257)
2014
2
Myopathy in hereditary leiomyomatosis and renal cell cancer in an extended family. (25354562)
2014
3
Fumarate hydratase immunohistochemical staining may help to identify patients with multiple cutaneous and uterine leiomyomatosis (MCUL) and hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome. (25292446)
2014
4
Adrenal nodular hyperplasia in hereditary leiomyomatosis and renal cell cancer. (22982371)
2013
5
Bilateral ovarian steroid cell tumours and massive macronodular adrenocortical disease in a patient with hereditary leiomyomatosis and renal cell cancer syndrome. (22565324)
2012
6
Hereditary leiomyomatosis and renal cell cancer presenting as metastatic kidney cancer at 18 years of age: implications for surveillance. (22086304)
2012
7
Familial renal cancer as an indicator of hereditary leiomyomatosis and renal cell cancer syndrome. (22127509)
2012
8
Protein Profiling of Blood Samples from Patients with Hereditary Leiomyomatosis and Renal Cell Cancer by Surface-Enhanced Laser Desorption/Ionization Time-of-Flight Mass Spectrometry. (23203078)
2012
9
Novel FH mutations in families with hereditary leiomyomatosis and renal cell cancer (HLRCC) and patients with isolated type 2 papillary renal cell carcinoma. (21398687)
2011
10
Hereditary leiomyomatosis and renal cell cancer in families referred for fumarate hydratase germline mutation analysis. (20618355)
2011
11
Hereditary leiomyomatosis and renal cell cancer: update on clinical and molecular characteristics. (21404119)
2011
12
A case report of hereditary leiomyomatosis and renal cell cancer. (20510956)
2010
13
Wilms tumour as a possible early manifestation of hereditary leiomyomatosis and renal cell cancer? (19183174)
2009
14
Array comparative genomic hybridization identifies a distinct DNA copy number profile in renal cell cancer associated with hereditary leiomyomatosis and renal cell cancer. (19373782)
2009
15
LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer. (19276158)
2009
16
Evidence for a founder effect of the germline fumarate hydratase gene mutation R58P causing hereditary leiomyomatosis and renal cell cancer (HLRCC). (17908262)
2008
17
Mutation screening of fumarate hydratase by multiplex ligation-dependent probe amplification: detection of exonic deletion in a patient with leiomyomatosis and renal cell cancer. (18503824)
2008
18
Association of germline mutations in the fumarate hydratase gene and uterine fibroids in women with hereditary leiomyomatosis and renal cell cancer. (19075141)
2008
19
Mechanisms of disease: hereditary leiomyomatosis and renal cell cancer--a distinct form of hereditary kidney cancer. (17287871)
2007
20
Compensatory alterations in energy homeostasis characterized in uterine tumors from hereditary leiomyomatosis and renal cell cancer. (17383644)
2007
21
Hereditary leiomyomatosis and renal cell cancer: a syndrome associated with an aggressive form of inherited renal cancer. (17509289)
2007
22
Hereditary leiomyomatosis and renal cell cancer: an unusual and aggressive form of hereditary renal carcinoma. (17392716)
2007
23
The syndrome of hereditary leiomyomatosis and renal cell cancer (HLRCC): The clinical features of an individual with a fumarate hydratase gene mutation. (17034471)
2006
24
Fumarate hydratase enzyme activity in lymphoblastoid cells and fibroblasts of individuals in families with hereditary leiomyomatosis and renal cell cancer. (16597677)
2006
25
Novel mutations in FH and expansion of the spectrum of phenotypes expressed in families with hereditary leiomyomatosis and renal cell cancer. (15937070)
2006
26
Cutaneous leiomyomas: a clinical marker of risk for hereditary leiomyomatosis and renal cell cancer. (16948378)
2006
27
Missense mutations in fumarate hydratase in multiple cutaneous and uterine leiomyomatosis and renal cell cancer. (16237213)
2005
28
Evidence of increased microvessel density and activation of the hypoxia pathway in tumours from the hereditary leiomyomatosis and renal cell cancer syndrome. (15586379)
2005
29
Hereditary leiomyomatosis and renal cell cancer (HLRCC). (15579034)
2004
30
Mutations in the fumarate hydratase gene cause hereditary leiomyomatosis and renal cell cancer in families in North America. (12772087)
2003
31
Few FH mutations in sporadic counterparts of tumor types observed in hereditary leiomyomatosis and renal cell cancer families. (12183404)
2002
32
Hereditary Leiomyomatosis and Renal Cell Cancer (20301430)
1993

Variations for Leiomyomatosis and Renal Cell Cancer

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UniProtKB/Swiss-Prot genetic disease variations for Leiomyomatosis and Renal Cell Cancer:

64
id Symbol AA change Variation ID SNP ID
1FHp.Lys230ArgVAR_002445
2FHp.Asn107ThrVAR_013497
3FHp.Ala117ProVAR_013498
4FHp.His180ArgVAR_013499
5FHp.Gln185ArgVAR_013500
6FHp.Arg233HisVAR_013501rs28933069
7FHp.Gly282ValVAR_013502
8FHp.Met328ArgVAR_013503

Clinvar genetic disease variations for Leiomyomatosis and Renal Cell Cancer:

7
id Gene Variation Type Significance SNP ID Assembly Location
1FHNM_000143.3(FH): c.301C> T (p.Arg101Ter)single nucleotide variantPathogenicrs121913120GRCh37Chr 1, 241676980: 241676980
2FHFH, 2-BP DELdeletionPathogenic
3FHNM_000143.3(FH): c.1027C> T (p.Arg343Ter)single nucleotide variantPathogenicrs121913122GRCh37Chr 1, 241667423: 241667423
4FHNM_000143.3(FH): c.698G> A (p.Arg233His)single nucleotide variantPathogenicrs121913123GRCh37Chr 1, 241671943: 241671943
5FHNM_000143.3(FH): c.698G> T (p.Arg233Leu)single nucleotide variantPathogenicrs121913123GRCh37Chr 1, 241671943: 241671943
6FHNM_000143.3(FH): c.302G> C (p.Arg101Pro)single nucleotide variantPathogenicrs75086406GRCh37Chr 1, 241676979: 241676979
7FHNM_000143.3(FH): c.320A> C (p.Asn107Thr)single nucleotide variantPathogenicrs121913121GRCh37Chr 1, 241676961: 241676961

Cosmic variations for Leiomyomatosis and Renal Cell Cancer:

8 (show all 89)
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
114312VHLkidney,NS,carcinoma,renal cell carcinoma3
218346VHLkidney,NS,carcinoma,papillary renal cell carcinoma3
317807VHLkidney,NS,carcinoma,papillary renal cell carcinoma3
414311VHLkidney,NS,carcinoma,papillary renal cell carcinoma3
517983VHLkidney,NS,carcinoma,renal cell carcinoma3
614284VHLkidney,NS,carcinoma,renal cell carcinoma3
717957VHLkidney,NS,carcinoma,renal cell carcinoma3
825673VHLkidney,NS,carcinoma,papillary renal cell carcinoma3
930286VHLkidney,NS,carcinoma,papillary renal cell carcinoma3
1017808VHLkidney,NS,carcinoma,papillary renal cell carcinoma3
1114382VHLkidney,NS,carcinoma,renal cell carcinoma3
1230410VHLkidney,NS,carcinoma,renal cell carcinoma3
13690METkidney,NS,carcinoma,papillary renal cell carcinoma3
14704METkidney,NS,carcinoma,papillary renal cell carcinoma3
15698METkidney,NS,carcinoma,papillary renal cell carcinoma3
16689METkidney,NS,carcinoma,papillary renal cell carcinoma3
17484661METkidney,NS,carcinoma,papillary renal cell carcinoma3
18697METkidney,NS,carcinoma,papillary renal cell carcinoma3
19696METkidney,NS,carcinoma,papillary renal cell carcinoma3
20688METkidney,NS,carcinoma,papillary renal cell carcinoma3
21691METkidney,NS,carcinoma,papillary renal cell carcinoma3
2211984TP53kidney,NS,carcinoma,renal cell carcinoma3
2310709TP53kidney,NS,carcinoma,papillary renal cell carcinoma3
2410648TP53kidney,NS,carcinoma,renal cell carcinoma3
2510656TP53kidney,NS,carcinoma,renal cell carcinoma3
2643697TP53kidney,NS,carcinoma,papillary renal cell carcinoma3
2743850TP53kidney,NS,carcinoma,papillary renal cell carcinoma3
28462BRAFkidney,NS,carcinoma,papillary renal cell carcinoma3
291131BRAFkidney,NS,carcinoma,papillary renal cell carcinoma3
30760PIK3CAkidney,NS,carcinoma,papillary renal cell carcinoma3
31763PIK3CAkidney,NS,carcinoma,papillary renal cell carcinoma3
321676793KRASkidney,NS,carcinoma,renal cell carcinoma3
33521KRASkidney,NS,carcinoma,papillary renal cell carcinoma3
34718FGFR3kidney,NS,carcinoma,papillary renal cell carcinoma3
353993568FGFR3kidney,NS,carcinoma,papillary renal cell carcinoma3
36307445GIT2kidney,NS,carcinoma,renal cell carcinoma3
371677336GIT2kidney,NS,carcinoma,renal cell carcinoma3
381682757KLHL4kidney,NS,carcinoma,renal cell carcinoma3
391683084FBXW4kidney,NS,carcinoma,renal cell carcinoma3
4014060ERBB2kidney,NS,carcinoma,papillary renal cell carcinoma3
4121945EGFRkidney,NS,carcinoma,papillary renal cell carcinoma3
421680669EPORkidney,NS,carcinoma,renal cell carcinoma3
431675310HKDC1kidney,NS,carcinoma,renal cell carcinoma3
4422853E2F7kidney,NS,carcinoma,renal cell carcinoma3
451682806GUCY2Fkidney,NS,carcinoma,renal cell carcinoma3
46188258HIVEP3kidney,NS,carcinoma,papillary renal cell carcinoma3
47742462GFRALkidney,NS,carcinoma,papillary renal cell carcinoma3
481670294FLNBkidney,NS,carcinoma,renal cell carcinoma3
4924266DGKIkidney,NS,carcinoma,renal cell carcinoma3
50375284ANKHD1kidney,NS,carcinoma,papillary renal cell carcinoma3
51375283ANKHD1-EIF4EBP3kidney,NS,carcinoma,papillary renal cell carcinoma3
521671070ANKRD17kidney,NS,carcinoma,renal cell carcinoma3
531671225ANK2kidney,NS,carcinoma,renal cell carcinoma3
5422805ADAM7kidney,NS,carcinoma,renal cell carcinoma3
551181978ADARB1kidney,NS,carcinoma,papillary renal cell carcinoma3
5625413ANKRD60kidney,NS,carcinoma,renal cell carcinoma3
571681624CBFA2T2kidney,NS,carcinoma,renal cell carcinoma3
58302052DHX9kidney,NS,carcinoma,papillary renal cell carcinoma3
591583146DNMT3Akidney,NS,carcinoma,papillary renal cell carcinoma3
6013489CDKN2Akidney,NS,carcinoma,renal cell carcinoma3
611683097CDC42BPBkidney,NS,carcinoma,renal cell carcinoma3
62274461CDC73kidney,NS,carcinoma,papillary renal cell carcinoma3
631676177DPF2kidney,NS,carcinoma,renal cell carcinoma3
6421103ROR1kidney,NS,carcinoma,renal cell carcinoma3
651669645SATB2kidney,NS,carcinoma,renal cell carcinoma3
66487039SCAIkidney,NS,carcinoma,papillary renal cell carcinoma3
67485065RHEBkidney,NS,carcinoma,papillary renal cell carcinoma3
681222993RAD23Bkidney,NS,carcinoma,papillary renal cell carcinoma3
691675206RBP3kidney,NS,carcinoma,renal cell carcinoma3
701675176RETkidney,NS,carcinoma,renal cell carcinoma3
7124274SMAD4kidney,NS,carcinoma,renal cell carcinoma3
72110414SMARCB1kidney,NS,carcinoma,papillary renal cell carcinoma3
7325383TRPA1kidney,NS,carcinoma,renal cell carcinoma3
741683057TTF2kidney,NS,carcinoma,renal cell carcinoma3
751674226ZFP41kidney,NS,carcinoma,renal cell carcinoma3
761268384TP63kidney,NS,carcinoma,papillary renal cell carcinoma3
771360764SOX5kidney,NS,carcinoma,papillary renal cell carcinoma3
781683105TEX14kidney,NS,carcinoma,renal cell carcinoma3
79322959RAB3Ckidney,NS,carcinoma,renal cell carcinoma3
8021092NEK6kidney,NS,carcinoma,renal cell carcinoma3
81163384PDGFRAkidney,NS,carcinoma,papillary renal cell carcinoma3
821680798PIK3R2kidney,NS,carcinoma,renal cell carcinoma3
8327222MMP2kidney,NS,carcinoma,renal cell carcinoma3
841680950ZNF383kidney,NS,carcinoma,renal cell carcinoma3
851677789LIG4kidney,NS,carcinoma,renal cell carcinoma3
86964299MAP2K5kidney,NS,carcinoma,papillary renal cell carcinoma3
871669602WDR75kidney,NS,carcinoma,renal cell carcinoma3
8821735PMLkidney,NS,carcinoma,renal cell carcinoma3
89485575PMS2P11kidney,NS,carcinoma,papillary renal cell carcinoma3
901683107PTPRMkidney,NS,carcinoma,renal cell carcinoma3
911681684PTPRTkidney,NS,carcinoma,renal cell carcinoma3
921682139RAB36kidney,NS,carcinoma,renal cell carcinoma3
931673226PTPN12kidney,NS,carcinoma,renal cell carcinoma3
941677360PTPN11kidney,NS,carcinoma,renal cell carcinoma3
9523140PPP1R10kidney,NS,carcinoma,renal cell carcinoma3
9621847PREX2kidney,NS,carcinoma,renal cell carcinoma3
975260PTENkidney,NS,carcinoma,papillary renal cell carcinoma3

Expression for genes affiliated with Leiomyomatosis and Renal Cell Cancer

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Search GEO for disease gene expression data for Leiomyomatosis and Renal Cell Cancer.

Pathways for genes affiliated with Leiomyomatosis and Renal Cell Cancer

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Pathways related to Leiomyomatosis and Renal Cell Cancer according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1FH, LDHA
2
Show member pathways
TCA cycle38
pyruvate decarboxylation to acetyl CoA38
NAD phosphorylation and dephosphorylation38
TCA Cycle38
conversion of glucose to acetyl CoA and entry into the TCA cycle38
9.1FH, LDHA
39.1LDHA, BNIP3

Compounds for genes affiliated with Leiomyomatosis and Renal Cell Cancer

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Compounds related to Leiomyomatosis and Renal Cell Cancer according to GeneCards/GeneDecks:

(show all 13)
idCompoundScoreTop Affiliating Genes
15-aza-2deoxycytidine459.5BNIP3, THBS1
25fluorouracil459.4BNIP3, THBS1
3sb 20358045 6110.3THBS1, BNIP3
4paclitaxel45 51 1311.3BNIP3, THBS1
5pyruvate459.2FH, LDHA
6agarose459.2THBS1, LDHA
7lactate458.8BNIP3, LDHA, FH
8nadh45 26 1310.8FH, LDHA
9vegf458.7LDHA, BNIP3, THBS1
10nitric oxide45 26 1310.7LDHA, BNIP3, THBS1
11tyrosine458.4FH, LDHA, THBS1
12oxygen45 269.3FH, LDHA, BNIP3, THBS1
13glucose458.2FH, LDHA, BNIP3, THBS1

GO Terms for genes affiliated with Leiomyomatosis and Renal Cell Cancer

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Cellular components related to Leiomyomatosis and Renal Cell Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:00700628.5FH, LDHA, THBS1
2mitochondrionGO:00057398.3FH, LDHA, BNIP3

Biological processes related to Leiomyomatosis and Renal Cell Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to hypoxiaGO:00016669.3BNIP3, THBS1
2cellular metabolic processGO:00442378.8FH, LDHA

Products for genes affiliated with Leiomyomatosis and Renal Cell Cancer

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Sources for Leiomyomatosis and Renal Cell Cancer

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet