MCID: LMY004
MIFTS: 62

Leiomyosarcoma malady

Rare diseases, Cancer diseases categories
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Summaries for Leiomyosarcoma

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NIH Rare Diseases:42 Leiomyosarcoma is a rare cancerous tumor that consists of smooth (involuntary) muscle cells. leiomyosarcoma is a type of sarcoma. it spreads through the blood stream and can affect the lungs, liver, blood vessels, or any other soft tissue in the body. it is most often found in the uterus or abdomen. last updated: 8/3/2010

MalaCards based summary: Leiomyosarcoma, also known as leiomyosarcomas, is related to epithelioid leiomyosarcoma and retroperitoneal leiomyosarcoma. An important gene associated with Leiomyosarcoma is DES (desmin), and among its related pathways are Aurora B signaling and Nuclear signaling by ERBB4. The compounds toluidine and eosin have been mentioned in the context of this disorder. Affiliated tissues include uterus, smooth muscle and liver, and related mouse phenotypes are limbs/digits/tail and renal/urinary system.

Disease Ontology:8 A malignant smooth muscle cancer that can arise almost anywhere in the body, but is most common in the uterus, abdomen, or pelvis.

Wikipedia:65 Leiomyosarcoma (Gr. \"smooth muscle connective tissue tumor\"), also referred to as LMS, is a malignant... more...

Aliases & Classifications for Leiomyosarcoma

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 62UMLS, 39NCIt, 57SNOMED-CT, 34MeSH, 35MESH via Orphanet, 63UMLS via Orphanet
See all sources

Leiomyosarcoma, Aliases & Descriptions:

Name: Leiomyosarcoma 8 42 10 44 48 62
 
Leiomyosarcomas 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Orphanet: 48 
Rare tumors


External Ids:

Disease Ontology8 DOID:1967
NCIt39 C3158
MeSH34 D007890
MESH via Orphanet35 D007890
UMLS via Orphanet63 C0023269

Related Diseases for Leiomyosarcoma

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Diseases in the Leiomyosarcoma family:

Inflammatory Leiomyosarcoma

Diseases related to Leiomyosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 300)
idRelated DiseaseScoreTop Affiliating Genes
1epithelioid leiomyosarcoma31.6ACTC1, VIM, DES
2retroperitoneal leiomyosarcoma31.5SMARCB1
3chondroma31.0PDGFRA
4gastrointestinal stromal tumor31.0PDGFRA, KIT
5uterine fibroid30.8PGR, FH
6liposarcoma30.7MDM2, VIM, DES
7leiomyomatosis30.7PGR, FH
8paraganglioma30.7FH, S100B, KIT
9myoma30.6FH, PGR
10kidney cancer30.6FH
11fibrous histiocytoma30.5DES, VIM, ACTC1, S100B
12cystadenocarcinoma30.5MUC1
13smooth muscle tumor30.3KIT, S100B, ACTC1, VIM, PGR, DES
14lymphangioleiomyomatosis30.3DES, PGR
15endometrial stromal sarcoma30.3KIT, PDGFRA, ACTC1, VIM, PGR, DES
16carney triad30.3PDGFRA, KIT
17leiomyoma30.3PGR, DES, VIM, ACTC1, FH, PDGFRA
18embryonal rhabdomyosarcoma30.2DES, ACTC1, WT1
19neurilemmoma30.2SMARCB1
20granular cell tumor30.1DES, VIM, S100B
21lipoma30.1MDM2, DES
22dedifferentiated liposarcoma30.1DES, KIT, MDM2
23uterine sarcoma30.1DES, KIT, MDM2
24papillary carcinoma30.0PGR, MUC1, ACTC1
25endometriosis30.0PGR, ACTC1, PDGFRA
26neurofibromatosis30.0PDGFRA, S100B, KIT
27giant cell tumor29.9DES, VIM, MUC1, ACTC1, S100B
28desmoid tumor29.9DES, ACTC1, PDGFRA, KIT
29fibrosarcoma29.8DES, VIM, ACTC1, PDGFRA, MDM2
30angiosarcoma29.8VIM, MUC1, ACTC1, PDGFRA
31synovial sarcoma29.7DES, VIM, MUC1, S100B, KIT, MDM2
32adenocarcinoma29.6WT1, MDM2, ACTC1, MUC1, VIM, PGR
33breast cancer29.5PGR, VIM, MUC1, ACTC1, MDM2
34ovarian cancer29.4PGR, MUC1, PDGFRA, MDM2
35chondrosarcoma29.2DES, VIM, MUC1, PDGFRA, S100B, MDM2
36glioblastoma29.1SMARCB1, PDGFRA, S100B, KIT, MDM2
37melanoma29.1DES, VIM, ACTC1, PDGFRA, S100B, KIT
38sarcoma28.9WT1, MDM2, KIT, S100B, PDGFRA, ACTC1
39rhabdomyosarcoma28.9DES, SMARCB1, WT1, MDM2, S100B, PDGFRA
40gastric leiomyosarcoma10.7
41cutaneous leiomyosarcoma10.7
42myxoid leiomyosarcoma10.7
43infantile myofibromatosis10.6DES
44fasciitis10.5ACTC1
45progesterone resistance10.5PGR
46pulmonary artery leiomyosarcoma10.5
47dermatofibrosarcoma protuberans10.5MDM2
48juvenile xanthogranuloma10.5S100B
49rosai-dorfman disease10.5S100B
50hidradenoma10.5MUC1

Graphical network of the top 20 diseases related to Leiomyosarcoma:



Diseases related to leiomyosarcoma

Symptoms for Leiomyosarcoma

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Drugs & Therapeutics for Leiomyosarcoma

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Drug clinical trials:

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Genetic Tests for Leiomyosarcoma

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Anatomical Context for Leiomyosarcoma

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MalaCards organs/tissues related to Leiomyosarcoma:

32
Uterus, Smooth muscle, Liver, Lung, Breast, Bone, Colon, Pancreas, Lymph node, Heart, Thyroid, Kidney, Cervix, Skin, Ovary, Prostate, Small intestine, Tongue, Adrenal gland, Endothelial, Brain, Spinal cord, Skeletal muscle, Testis, Testes, Tonsil, Myeloid

Animal Models for Leiomyosarcoma or affiliated genes

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MGI Mouse Phenotypes related to Leiomyosarcoma:

36 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.7MDM2, KIT, PDGFRA, PGR
2MP:00053678.2FH, PDGFRA, KIT, MDM2, WT1
3MP:00107718.1PGR, MUC1, PDGFRA, S100B, KIT, MDM2
4MP:00053867.9DES, PGR, VIM, PDGFRA, S100B, KIT
5MP:00030127.9PGR, MUC1, PDGFRA, KIT, MDM2, WT1
6MP:00053797.9PGR, MUC1, PDGFRA, KIT, WT1
7MP:00053707.8SMARCB1, MUC1, KIT, MDM2, WT1
8MP:00020067.7SMARCB1, PGR, MUC1, PDGFRA, KIT, MDM2
9MP:00053817.7SMARCB1, MUC1, PDGFRA, KIT, MDM2
10MP:00053697.6WT1, DES, PGR, VIM, ACTC1, PDGFRA
11MP:00028737.3PGR, MUC1, ACTC1, PDGFRA, S100B, KIT
12MP:00053807.3SMARCB1, PGR, VIM, PDGFRA, KIT, MDM2
13MP:00053897.2SMARCB1, PGR, VIM, PDGFRA, KIT, MDM2
14MP:00053977.2SMARCB1, PGR, VIM, PDGFRA, KIT, MDM2
15MP:00053877.1SMARCB1, PGR, VIM, PDGFRA, KIT, MDM2
16MP:00053787.1SMARCB1, VIM, ACTC1, PDGFRA, KIT, MDM2
17MP:00053856.8DES, SMARCB1, PGR, VIM, ACTC1, PDGFRA
18MP:00053846.7SMARCB1, PGR, VIM, ACTC1, FH, PDGFRA
19MP:00053766.5DES, SMARCB1, PGR, VIM, MUC1, ACTC1
20MP:00107686.4DES, SMARCB1, PGR, VIM, ACTC1, FH

Publications for Leiomyosarcoma

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Articles related to Leiomyosarcoma:

(show top 50)    (show all 1011)
idTitleAuthorsYear
1
Gastric leiomyosarcoma as a rare cause of gastric outlet obstruction and perforation: a case report. (25069607)
2014
2
Laryngeal leiomyosarcoma, a case report and review of articles. (24303449)
2013
3
Adjuvant therapy for high-grade, uterus-limited leiomyosarcoma: results of a phase 2 trial (SARC 005). (23335221)
2013
4
External validation of a prognostic nomogram for overall survival in women with uterine leiomyosarcoma. (23456762)
2013
5
Recurrent leiomyosarcoma presenting as malignant arterial tumor thrombus. (24371672)
2013
6
Primary leiomyosarcoma of the thyroid. (23833760)
2013
7
Near total occlusion of the main pulmonary artery and destruction of pulmonary valve by leiomyosarcoma. (23223120)
2013
8
Primary adrenal leiomyosarcoma: a case report with immunohistochemical study and review of literature. (23575089)
2013
9
Cell cycle regulatory markers in uterine atypical leiomyoma and leiomyosarcoma: immunohistochemical study of 68 cases with clinical follow-up. (23552380)
2013
10
Leiomyosarcoma after hysteroscopic myomectomy: a case report. (23327066)
2012
11
Intracranial dural metastasis from uterine leiomyosarcoma with orbital extension. (22231469)
2012
12
Leiomyosarcoma of the inferior vena cava extending into the right atrium. A rare differential diagnosis of a right atrial tumor with fatal outcome. (22430283)
2012
13
Case report: leiomyosarcoma of the parapharyngeal space. (22829041)
2012
14
Topoisomerase IIalpha activity and tumor cell proliferation level from the degree of bromodeoxyuridine label in uterine body leiomyosarcoma]. (21506336)
2011
15
Potential role of LMP2 as tumor-suppressor defines new targets for uterine leiomyosarcoma therapy. (22355695)
2011
16
CSF1 expression in nongynecological leiomyosarcoma is associated with increased tumor angiogenesis. (21854753)
2011
17
Phase II study of sunitinib malate, a multitargeted tyrosine kinase inhibitor in patients with relapsed or refractory soft tissue sarcomas. Focus on three prevalent histologies: leiomyosarcoma, liposarcoma and malignant fibrous histiocytoma. (21154746)
2011
18
Successful surgical management of a recurrent leiomyosarcoma of the inferior vena cava. (21283976)
2011
19
Cutaneous leiomyosarcoma originating in a symplastic pilar leiomyoma: a rare occurrence and potential diagnostic pitfall. (19780873)
2011
20
Primary intracranial leiomyosarcoma in an HIV-infected patient. (20676716)
2011
21
Leiomyosarcoma with partial rhabdomyoblastic differentiation: first case report of primary cardiac origin. (21329505)
2011
22
Leiomyosarcoma of the temporal bone. (21879494)
2011
23
Leiomyosarcoma of the inferior vena cava: clinicopathologic study of 40 cases. (20463568)
2010
24
Case Report of Suspected Rhabdomyolysis during Treatment with Trabectedin in a Patient with Metastatic Leiomyosarcoma. (21611101)
2010
25
Surgical resection of the inferior vena cava for leiomyosarcoma. (20494550)
2010
26
A case of high-grade leiomyosarcoma of the bladder with delayed onset and very poor prognosis. (20302611)
2010
27
Mice-lacking LMP2, immuno-proteasome subunit, as an animal model of spontaneous uterine leiomyosarcoma. (21203912)
2010
28
Leiomyosarcoma uteri in a white woman. (20418648)
2010
29
Primary hepatic leiomyosarcoma in a young man after Hodgkin's disease: diagnostic pitfalls and therapeutic challenge. (19688980)
2009
30
Epithelioid leiomyosarcoma with rhabdoid features. (17943409)
2007
31
A high-grade uterine leiomyosarcoma with human chorionic gonadotropin production. (16810064)
2006
32
Oncogenic property of acrogranin in human uterine leiomyosarcoma: direct evidence of genetic contribution in in vivo tumorigenesis. (16533762)
2006
33
p53, epidermal growth factor, and platelet-derived growth factor in uterine leiomyosarcoma and leiomyomas. (16681772)
2006
34
Bcl-2 receptor expression in patients with uterine smooth muscle tumors: an immunohistochemical analysis comparing leiomyoma, uterine smooth muscle tumor of uncertain malignant potential, and leiomyosarcoma. (15051039)
2004
35
Expression of matrix metalloproteinases in patients with uterine smooth muscle tumors: an immunohistochemical analysis of MMP-1 and MMP-2 protein expression in leiomyoma, uterine smooth muscle tumor of uncertain malignant potential, and leiomyosarcoma. (15051038)
2004
36
Ki-67 expression in patients with uterine leiomyomas, uterine smooth muscle tumors of uncertain malignant potential (STUMP) and uterine leiomyosarcomas (LMS). (15488127)
2004
37
Primary paratesticular epithelioid leiomyosarcoma. (12740499)
2003
38
Low frequency of somatic mutations in the FH/multiple cutaneous leiomyomatosis gene in sporadic leiomyosarcomas and uterine leiomyomas. (12177782)
2002
39
Retroperitoneal leiomyomas: a clinicopathologic and immunohistochemical study of 56 cases with a comparison to retroperitoneal leiomyosarcomas. (11684951)
2001
40
Myxoid leiomyosarcoma of the left atrium: a rare malignancy of the heart and its comparison with atrial myxoma. (11264566)
2001
41
Comparative immunohistochemical and molecular analysis of uterine and extrauterine leiomyosarcomas. (10574596)
1999
42
Progesterone receptors in gastric leiomyosarcoma. (9840313)
1998
43
Sclerotic primary cutaneous leiomyosarcoma. (8599440)
1995
44
Pulmonary myxoid leiomyosarcoma. (8581153)
1995
45
Hyponatremic hypertensive syndrome and massive proteinuria in a patient with renin-producing leiomyosarcoma. (8023829)
1994
46
Gastric leiomyosarcoma. (1609721)
1992
47
Leiomyosarcomas have a poorer prognosis than mixed mesodermal tumours when adjusting for known prognostic factors: the result of a retrospective study of 423 cases of uterine sarcoma. (1326319)
1992
48
Intermediate and fine cytofilaments in cutaneous and subcutaneous leiomyosarcomas. (1716444)
1991
49
Uterine malignancy developing after long term use of IUCD additional report of 2 cases: endometrial stromal sarcoma and leiomyosarcoma. (2597086)
1989
50
Occurrence of cicatricial pemphigoid and leiomyosarcoma in a psoriatic patient. (3891438)
1985

Variations for Leiomyosarcoma

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Expression for genes affiliated with Leiomyosarcoma

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Expression patterns in normal tissues for genes affiliated with Leiomyosarcoma

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Pathways for genes affiliated with Leiomyosarcoma

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Pathways related to Leiomyosarcoma according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Signaling by Aurora kinases37
Aurora C signaling37
9.9DES, VIM
2
Show member pathways
9.7S100B, PGR
39.6ACTC1, VIM, DES
4
Show member pathways
9.6ACTC1, VIM, DES
59.3ACTC1, PDGFRA, KIT
69.1MDM2, PDGFRA, VIM
7
Show member pathways
9.1PDGFRA, KIT, MDM2
89.1MDM2, KIT, PDGFRA
98.8WT1, MDM2, PDGFRA
108.8FH, PDGFRA, KIT, MDM2
11
Show member pathways
8.3MDM2, KIT, S100B, PDGFRA, PGR
12
Show member pathways
8.1DES, VIM, MUC1, PDGFRA, KIT, MDM2

Compounds for genes affiliated with Leiomyosarcoma

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Compounds related to Leiomyosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1toluidine449.9DES, VIM, KIT
2eosin449.7VIM, MUC1, S100B
3orcein449.6VIM, S100B, DES, ACTC1
4biotin44 24 1111.5VIM, DES, ACTC1, MUC1
5progestin449.4MUC1, VIM, DES, PGR
6dihydrotestosterone44 28 24 1112.3VIM, DES, PGR, MUC1
7s 100449.2VIM, MUC1, S100B, ACTC1, DES
8reticulin449.2ACTC1, S100B, VIM, DES, MUC1
9mucicarmine449.2MUC1, S100B, ACTC1, VIM, DES
10trastuzumab44 50 1111.2PGR, KIT, MDM2, MUC1
11vincristine44 50 1111.0WT1, MDM2, KIT, VIM
12lactate449.0S100B, FH, VIM, DES, KIT
13hyaluronic acid44 2410.0WT1, MUC1, VIM, DES
14adriamycin448.9DES, VIM, MDM2, MUC1, PGR
15iron44 249.9DES, ACTC1, S100B, MDM2, VIM
16actinomycin d448.9DES, VIM, MUC1, KIT, MDM2
17folate448.9PDGFRA, VIM, PGR, MUC1
18paclitaxel44 50 1110.9PGR, S100B, MDM2, KIT, VIM
19methotrexate50 44 1110.9KIT, VIM, MDM2, PGR, MUC1
20hematoxylin448.9KIT, ACTC1, DES, VIM, MUC1, S100B
21formaldehyde44 249.9MUC1, VIM, DES, ACTC1, S100B, KIT
22estradiol44 24 1110.8MDM2, MUC1, VIM, PGR, DES
23valine448.8S100B, VIM, MDM2, KIT
245fluorouracil448.8MDM2, KIT, MUC1, PGR
25ribonucleic acid448.8PGR, WT1, MUC1, ACTC1, KIT
26glutamine448.7PGR, WT1, KIT, S100B, VIM
27b 723448.6ACTC1, MUC1, WT1, S100B, VIM, DES
28dexamethasone44 50 28 1111.5PGR, MUC1, MDM2, S100B, VIM, ACTC1
29doxorubicin44 50 1110.5PGR, VIM, DES, MDM2, WT1, KIT
30glucose448.4MUC1, DES, ACTC1, KIT, FH, S100B
31proline448.4DES, VIM, WT1, S100B, FH, MDM2
32glycogen44 249.3ACTC1, DES, MDM2, VIM, MUC1, S100B
33oxygen44 249.3FH, S100B, DES, MDM2, ACTC1, MUC1
34cyclic amp44 249.2DES, VIM, MUC1, S100B, MDM2
35creatinine448.2DES, WT1, FH, ACTC1, MUC1, S100B
36nitric oxide44 24 1110.2KIT, WT1, DES, MUC1, S100B, MDM2
37threonine448.2KIT, MDM2, DES, WT1, S100B, MUC1
38aspartate448.1S100B, MDM2, KIT, PDGFRA, FH, VIM
39steroid448.1DES, ACTC1, MDM2, S100B, KIT, WT1
40imatinib44 50 1110.0WT1, MDM2, KIT, S100B, PDGFRA, ACTC1
41serine447.8DES, KIT, S100B, MUC1, WT1, MDM2
42thymidine44 248.8KIT, DES, MUC1, WT1, MDM2, S100B
43cysteine447.6MUC1, S100B, PGR, VIM, WT1, DES
44progesterone44 28 61 24 1111.4DES, KIT, S100B, ACTC1, MUC1, VIM
45testosterone44 61 24 1110.4PGR, VIM, MUC1, ACTC1, S100B, MDM2
46retinoic acid44 248.3MUC1, PGR, ACTC1, S100B, DES, VIM
47tyrosine447.1KIT, MDM2, WT1, ACTC1, S100B, MUC1
48paraffin446.8PGR, VIM, DES, WT1, MDM2, KIT
49vegf446.8WT1, PGR, MUC1, DES, ACTC1, PDGFRA
50estrogen446.8ACTC1, S100B, WT1, MDM2, KIT, PDGFRA

GO Terms for genes affiliated with Leiomyosarcoma

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Cellular components related to Leiomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:0057377.0WT1, MDM2, S100B, PDGFRA, FH, ACTC1

Biological processes related to Leiomyosarcoma according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1cardiac myofibril assemblyGO:0550039.9ACTC1, PDGFRA
2muscle filament slidingGO:0300499.9ACTC1, VIM, DES
3positive regulation of phospholipase C activityGO:0108639.9KIT, PDGFRA
4cell chemotaxisGO:0603269.6KIT, PDGFRA
5positive regulation of phosphatidylinositol 3-kinase activityGO:0435529.5KIT, PDGFRA
6male genitalia developmentGO:0305399.5WT1, PDGFRA
7adrenal gland developmentGO:0303259.4WT1, PDGFRA
8phosphatidylinositol-mediated signalingGO:0480159.3MDM2, KIT, PDGFRA
9fibroblast growth factor receptor signaling pathwayGO:0085439.3PDGFRA, KIT, MDM2
10Fc-epsilon receptor signaling pathwayGO:0380959.3PDGFRA, KIT, MDM2
11epidermal growth factor receptor signaling pathwayGO:0071739.2MDM2, KIT, PDGFRA
12positive regulation of cell proliferationGO:0082849.0PDGFRA, S100B, KIT, MDM2
13neurotrophin TRK receptor signaling pathwayGO:0480118.8MDM2, KIT, PDGFRA
14innate immune responseGO:0450878.7PDGFRA, S100B, KIT, MDM2

Molecular functions related to Leiomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane receptor protein tyrosine kinase activityGO:0047149.6KIT, PDGFRA
2scaffold protein bindingGO:0971109.4MDM2, VIM
3identical protein bindingGO:0428028.9MDM2, S100B, VIM, DES
4p53 bindingGO:0020398.7SMARCB1, MUC1, MDM2
5protein bindingGO:0055155.9WT1, DES, SMARCB1, PGR, VIM, MUC1

Products for genes affiliated with Leiomyosarcoma

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Sources for Leiomyosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet