MCID: LMY004
MIFTS: 62

Leiomyosarcoma malady

Cancer diseases category

Summaries for Leiomyosarcoma

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8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Leiomyosarcoma is a rare cancerous tumor that consists of smooth (involuntary) muscle cells. leiomyosarcoma is a type of sarcoma. it spreads through the blood stream and can affect the lungs, liver, blood vessels, or any other soft tissue in the body. it is most often found in the uterus or abdomen. last updated: 8/3/2010

MalaCards: Leiomyosarcoma, also known as leiomyomosarcoma, no subtype, is related to epithelioid leiomyosarcoma and leiomyoma. An important gene associated with Leiomyosarcoma is DES (desmin), and among its related pathways are Rho Family GTPases and PIP3 activates AKT signaling. The compounds paraffin and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include uterus, smooth muscle and liver, and related mouse phenotypes are behavior/neurological and normal.

Disease Ontology:8 A malignant smooth muscle cancer that can arise almost anywhere in the body, but is most common in the uterus, abdomen, or pelvis.

Wikipedia:63 Leiomyosarcoma (Gr. \"smooth muscle connective tissue tumor\"), aka LMS, is a malignant (cancer) smooth... more...

Aliases & Classifications for Leiomyosarcoma

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

leiomyosarcoma 8 42 10 44 48 60
leiomyomosarcoma, no subtype 8
leiomyosarcoma nos 8
leiomyosarcomas 8


External Ids:

Disease Ontology8 DOID:1967
MeSH34 D007890
NCIt39 C3158
MESH via Orphanet35 D007890
SNOMED-CT via Orphanet57 443719001, 51549004
UMLS via Orphanet61 C0023269

Related Diseases for Leiomyosarcoma

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17GeneCards, 18GeneDecks
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Diseases in the Leiomyosarcoma family:

Inflammatory Leiomyosarcoma

Diseases related to Leiomyosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 316)
idRelated DiseaseScoreTop Affiliating Genes
1epithelioid leiomyosarcoma31.1ACTC1, DES, VIM
2leiomyoma30.9S100A1, PDGFRA, FH, DES, MYOG, PGR
3retroperitoneal leiomyosarcoma30.9SMARCB1
4sarcoma30.7VIM, CALD1, S100B, S100A1, PDGFRA, WT1
5endometrial stromal sarcoma30.4KIT, PGR, DES, PDGFRA, VIM, ACTC1
6gastrointestinal stromal tumor30.4PDGFRA, KIT
7smooth muscle tumor30.4VIM, CALD1, S100B, S100A1, DES, PGR
8retinoblastoma30.4WT1, MDM2, MYOG, ENO2, SMARCB1
9prostate leiomyosarcoma30.4PLCB2
10chondroma30.3PDGFRA
11liposarcoma30.3VIM, MDM2, DES
12paraganglioma30.2S100B, S100A1, FH, KIT, ENO2
13uterine carcinosarcoma30.2KIT
14rhabdomyosarcoma30.2S100B, S100A1, PDGFRA, WT1, MDM2, DES
15uterine fibroid30.2S100A1, FH, DES, MYOG, PGR
16fibrous histiocytoma30.2ACTC1, DES, S100B, VIM
17adenocarcinoma30.1VIM, WT1, MDM2, MUC1, PGR, ACTC1
18squamous cell carcinoma30.1VIM, S100A1, PDGFRA, MDM2, MUC1, ACTC1
19leiomyomatosis30.1FH, PGR
20synovial sarcoma30.0VIM, S100B, MDM2, DES, MUC1, KIT
21giant cell tumor30.0VIM, S100B, DES, MUC1, ACTC1
22osteosarcoma30.0MDM2, PDGFRA
23myoma30.0FH, PGR
24vascular cancer30.0CALD1
25glomus tumor29.9VIM, S100A1, DES, ACTC1
26fibrosarcoma29.9ACTC1, DES, MDM2, PDGFRA, VIM
27embryonal rhabdomyosarcoma29.9WT1, DES, MYOG, ACTC1
28colorectal cancer29.9PDGFRA, MDM2, MUC1
29epithelioid sarcoma29.9VIM, MUC1, SMARCB1
30malignant mesenchymoma29.9MYOG
31colon cancer29.9MDM2
32chondrosarcoma29.7VIM, S100B, S100A1, PDGFRA, MDM2, DES
33melanoma29.7VIM, S100B, S100A1, PDGFRA, MDM2, DES
34angiosarcoma29.7VIM, PDGFRA, MUC1, ACTC1
35alveolar rhabdomyosarcoma29.7WT1, MDM2, DES, MYOG, ENO2
36granular cell tumor29.7VIM, S100B, S100A1, DES, ENO2
37glioblastoma multiforme29.7S100B, PDGFRA, MDM2, KIT, SMARCB1
38lipoma29.7DES, MDM2, S100A1
39breast cancer29.7VIM, S100A1, MDM2, MUC1, PGR, ACTC1
40neurofibromatosis29.7S100B, PDGFRA, KIT, ENO2
41lymphangioleiomyomatosis29.7PGR, DES
42mesenchymal chondrosarcoma29.7VIM, DES, MUC1
43papillary carcinoma29.7ACTC1, PGR, MUC1, S100A1
44carney triad29.7PDGFRA, KIT
45kidney cancer29.7FH
46prostate cancer29.7ENO2, MDM2, FH, PDGFRA
47endometriosis29.7ACTC1, PGR, PDGFRA
48neurilemmoma29.7SMARCB1, ENO2
49bladder carcinoma29.7MDM2, FH
50pheochromocytoma29.7ENO2, FH

Graphical network of the top 20 diseases related to Leiomyosarcoma:



Diseases related to leiomyosarcoma

Clinical Features for Leiomyosarcoma

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Drugs & Therapeutics for Leiomyosarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Leiomyosarcoma

Drug clinical trials:

Search ClinicalTrials for Leiomyosarcoma

Search NIH Clinical Center for Leiomyosarcoma

Search CenterWatch for Leiomyosarcoma

Genetic Tests for Leiomyosarcoma

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Anatomical Context for Leiomyosarcoma

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32MalaCards
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MalaCards organs/tissues related to Leiomyosarcoma:

32
Uterus, Smooth muscle, Liver, Lung, Breast, Bone, Colon, Thyroid, Pancreas, Lymph node, Heart, Kidney, Cervix, Skin, Prostate, Tongue, Ovary, Small intestine, Adrenal gland, Endothelial, Spinal cord, Brain, Skeletal muscle, Myeloid, Testis, Testes, Tonsil

Animal Models for Leiomyosarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Leiomyosarcoma:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538611.0S100B, RASD1, ENO2, PGR, MYOG, S100A1
2MP:000287311.0PGR, WT1, ACTC1, PDGFRA, KIT, MUC1
3MP:000537611.0PGR, DES, PLCB2, PDGFRA, RASD1, MYOG
4MP:000538511.0ACTC1, KIT, PGR, DES, MDM2, WT1
5MP:000538410.9SMARCB1, KIT, ACTC1, RASD1, ENO2, VIM
6MP:001076810.9ACTC1, VIM, CALD1, SMARCB1, KIT, PGR
7MP:000536910.8WT1, ACTC1, PDGFRA, MDM2
8MP:000538710.8GPSM3, PDGFRA, WT1, MDM2, PGR, PLCB2
9MP:000538010.6SMARCB1, KIT, PGR, WT1, MYOG, MDM2
10MP:001077110.6MDM2, PDGFRA, S100B, MYOG, PLCB2
11MP:000200610.4PDGFRA, PGR, MUC1, MDM2, SMARCB1, KIT

Publications for Leiomyosarcoma

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50PubMed
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Articles related to Leiomyosarcoma:

(show top 50)    (show all 986)
idTitleAuthorsYear
1
Pulmonary leiomyosarcoma mimicking glomus tumor at first biopsy and surgically treated with isolated left main bronchus resection: rare clinical documentation. (23636708)
2013
2
Neurofibromatosis type 1, gastrointestinal stromal tumor, leiomyosarcoma and osteosarcoma: four cases of rare tumors and a review of the literature. (23218951)
2013
3
Incidental finding on a SPECT/CT of a retroperitoneal leiomyosarcoma imitating a hiatal hernia in 131I whole-body scan in thyroid cancer evaluation. (23850374)
2013
4
Leiomyosarcoma of the female breast: report of a case. (24426525)
2013
5
A large primary vaginal leiomyosarcoma diagnosed postoperatively and uterine leiomyomas treated with surgery and chemotherapy. (23919878)
2013
6
Iliocaval and aortoiliac reconstruction following en bloc retroperitoneal leiomyosarcoma resection. (23446129)
2013
7
Primary leiomyosarcoma of the mesentery in two sisters: clinical and molecular characteristics. (23625602)
2013
8
Multifocal, recurrent sinonasal leiomyosarcoma: case report and review of literature. (24315734)
2013
9
Complete regression of primary epicardial leiomyosarcoma with single agent doxorubicin in an elderly patient. (24091457)
2013
10
Intraosseous leiomyosarcoma of the mandible: a case report. (23540427)
2013
11
Huge leiomyosarcoma in the left atrium. (23861131)
2013
12
Uterine leiomyosarcoma producing granulocyte colony stimulating factor. (22317876)
2012
13
Adult primary pleomorphic leiomyosarcoma of forearm with axillary lymph node metastasis: a case report and literature review. (23174734)
2012
14
Hepatectomy due to a saphenous vein leiomyosarcoma metastasis. (22578683)
2012
15
Cervical leiomyosarcoma: what is the optimum management? (22884793)
2012
16
Stage IV Primary Vaginal Leiomyosarcoma with Lung and Breast Metastases. (22740804)
2012
17
Ileal leiomyosarcoma and lymph node granuloma. Relevance of a rare association. (22440051)
2012
18
Characterization of giant marker and ring chromosomes in a pleomorphic leiomyosarcoma of soft tissue by spectral karyotyping. (22641359)
2012
19
Multidisciplinary treatment and long-term outcomes in six patients with leiomyosarcoma of the inferior vena cava. (22347712)
2012
20
Potential role of LMP2 as an anti-oncogenic factor in human uterine leiomyosarcoma: morphological significance of calponin h1. (22659265)
2012
21
Thyroid leiomyosarcoma: primary or metastasis? That's the question! (21935659)
2011
22
A case of tumor lysis syndrome following chemotherapy for a uterine epithelioid leiomyosarcoma with focal rhabdomyosarcomatous differentiation. (21410837)
2011
23
Three-dimensional imaging of a huge right atrial leiomyosarcoma. (22257818)
2011
24
Primary renal leiomyosarcoma. (22078358)
2011
25
Patient with synchronous low grade leiomyosarcoma of the thigh, primary pancreatic neuroendocrine tumor, and lung metastases: Why biopsy of metastases should be the standard. (22811838)
2011
26
Pulmonary artery leiomyosarcoma: an unusual cause of shortness of breath. (19921308)
2011
27
Leiomyosarcoma of the tonsil. (21729441)
2011
28
Primary intracranial leiomyosarcoma in an immunocompetent patient: case report. (21063896)
2011
29
A case of high-grade leiomyosarcoma of the bladder with delayed onset and very poor prognosis. (20302611)
2010
30
Prognostic significance of c-Myc expression in soft tissue leiomyosarcoma. (19633646)
2009
31
Primary lung leiomyosarcoma detected by bronchoscopy cytology. (16078256)
2005
32
Inflammatory leiomyosarcoma of the retroperitoneum. (12650517)
2003
33
Differential Expression of IRS-1 and IRS-2 in Uterine Leiomyosarcomas with Distinct Oncogenic Phenotypes: Lack of Correlation with Downstream Signaling Events. (18521338)
2002
34
Specific but variable expression of h-caldesmon in leiomyosarcomas: an immunohistochemical reassessment of a novel myogenic marker. (11759055)
2001
35
Expression of CD44 standard and isoforms V3 and V6 in uterine smooth muscle tumors: a possible diagnostic tool for the diagnosis of leiomyosarcoma. (11727257)
2001
36
Wild-type p53 suppresses angiogenesis in human leiomyosarcoma and synovial sarcoma by transcriptional suppression of vascular endothelial growth factor expression. (10910082)
2000
37
Primary intraoral leiomyosarcoma of the tongue: an immunohistochemical study and review of the literature. (11036245)
2000
38
Epithelioid leiomyosarcoma of the uterine cervix. (9512340)
1998
39
Pulmonary myxoid leiomyosarcoma. (8581153)
1995
40
Retroperitoneal leiomyosarcoma and gastroparesis: a new association and review of tumor-associated intestinal pseudo-obstruction. (7639243)
1995
41
Leiomyosarcoma versus bizarre and cellular leiomyomas of the uterus: a comparative study based on the MIB-1 and proliferating cell nuclear antigen indices, p53 expression, DNA flow cytometry, and muscle specific actins. (8601525)
1995
42
Unique imagings of CT and MR in liver metastasis from gastric leiomyosarcoma. (8082867)
1994
43
Leiomyosarcoma (LMS) and endometrial stromal sarcoma (ESS) of the uterus. A survey of patients treated in the Norwegian Radium Hospital 1976-1985. (11578330)
1993
44
Chromosome aberrations and expression of ras and myc oncogenes in leiomyomas and a leiomyosarcoma of the uterus. (1516585)
1992
45
Pulmonary artery leiomyosarcoma. (1947375)
1991
46
Uterine malignancy developing after long term use of IUCD additional report of 2 cases: endometrial stromal sarcoma and leiomyosarcoma. (2386581)
1990
47
Uterine malignancy developing after long term use of IUCD additional report of 2 cases: endometrial stromal sarcoma and leiomyosarcoma. (2597086)
1989
48
Myxoid leiomyosarcoma of the uterus: case report and review of the literature. (2660575)
1989
49
Primary cutaneous leiomyosarcoma. A histological and immunohistochemical study of 9 cases, with ultrastructural correlation. (3294254)
1988
50
Epithelioid leiomyosarcoma originating in a hamartomatous polyp from a patient with Peutz-Jeghers syndrome. (3972226)
1985

Genetic Variations for Leiomyosarcoma

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Expression for genes affiliated with Leiomyosarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Leiomyosarcoma

Search GEO for disease gene expression data for Leiomyosarcoma.

Pathways for genes affiliated with Leiomyosarcoma

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51QIAGEN, 53Reactome, 37NCBI BioSystems Database, 4Cell Signaling Technology
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Compounds for genes affiliated with Leiomyosarcoma

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44Novoseek, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB
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Compounds related to Leiomyosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
1paraffin4411.3KIT, PGR, MUC1, VIM, S100B, S100A1
2retinoic acid44 2412.3DES, WT1, PDGFRA, VIM, S100B, MUC1
3vegf4411.3MYOG, ENO2, VIM, ACTC1, KIT, PGR
4progesterone44 59 28 11 2415.3ENO2, ACTC1, KIT, PGR, MUC1, DES
5testosterone44 59 11 2414.3MDM2, WT1, S100B, MYOG, MUC1, PGR
6tyrosine4411.3KIT, ENO2, ACTC1, MUC1, MYOG, DES
7calcium44 49 11 2414.2PDGFRA, DES, MYOG, MUC1, PLCB2, S100A1
8cysteine4411.2VIM, S100B, WT1, MDM2, DES, MYOG
9hematoxylin4411.2VIM, DES, MUC1, KIT, ACTC1, ENO2
10b 7234411.2ACTC1, MUC1, DES, WT1, S100A1, S100B
11nitric oxide44 11 2413.1ENO2, KIT, MUC1, MYOG, DES, WT1
12formaldehyde44 2412.1ENO2, VIM, KIT, MUC1, DES, S100B
13s 1004411.1S100B, ENO2, ACTC1, MUC1, DES, VIM
14imatinib44 49 1113.1PDGFRA, KIT, S100B, DES, MDM2, ACTC1
15thymidine44 2412.1WT1, S100B, MDM2, DES, PDGFRA, MUC1
16mucicarmine4411.1DES, S100A1, MUC1, S100B, VIM, ACTC1
17ribonucleic acid4411.1ACTC1, KIT, PGR, MUC1, MYOG, WT1
18reticulin4411.1VIM, ACTC1, S100B, MUC1, DES
19iron44 2412.1ENO2, S100A1, ACTC1, VIM, S100B, MDM2
20steroid4411.1WT1, MDM2, MYOG, DES, RASD1, ACTC1
21toluidine4411.1ENO2, S100A1, KIT, DES, VIM
22methotrexate44 49 1113.0MUC1, MDM2, VIM, PGR, ENO2, KIT
23orcein4411.0VIM, S100B, DES, ACTC1
24aspartate4411.0ENO2, PDGFRA, FH, MDM2, PGR
25glycogen44 2412.0ACTC1, KIT, MDM2
26biotin44 11 2413.0VIM, S100A1, DES, MUC1, ACTC1
27creatinine4411.0WT1, ACTC1, FH
28adriamycin4411.0DES, MUC1, PGR, MDM2, VIM
29doxorubicin44 49 1113.0MDM2, KIT, PGR, DES, WT1, VIM
30bromodeoxyuridine4411.0ENO2, MYOG, S100B, DES, VIM
31dexamethasone44 49 28 1114.0ENO2, S100B, MDM2, RASD1
32oxygen44 2411.9FH, MYOG, DES, MDM2, MUC1, S100B
33actomyosin4410.9CALD1, S100A1, VIM, ACTC1
34estrogen4410.9MYOG
35hyaluronic acid44 2411.9VIM, ENO2, WT1, DES, MUC1
36eosin4410.9MUC1, VIM, S100B
37forskolin44 49 1112.9WT1, VIM, ENO2, MYOG, S100B, MUC1
38proline4410.9DES, MDM2, WT1, FH, S100B, VIM
39trastuzumab44 49 1112.9MDM2, PGR, MUC1, KIT
40acetylcholine44 49 28 11 2414.9ENO2, MYOG, S100A1
412-methoxyethanol4410.8ACTC1, S100A1, VIM
42lactate4410.8ENO2, DES, FH, S100B, VIM, KIT
43glucose4410.8ACTC1, MUC1, MYOG
44progestin4410.7PGR, DES, VIM, MUC1
45glutamine4410.7ENO2, WT1
46etoposide44 49 59 1113.7VIM, S100B, WT1, MDM2, ENO2
4712-o-tetradecanoylphorbol 13-acetate4410.6MYOG, DES, WT1, VIM, MUC1
48paclitaxel44 49 1112.6PGR, MDM2, S100B
49adenylate4410.6ENO2, MYOG, DES, S100B, VIM, PGR
50vincristine44 49 1112.3MDM2, WT1, VIM, KIT

GO Terms for genes affiliated with Leiomyosarcoma

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16Gene Ontology
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Biological processes related to Leiomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cardiac myofibril assemblyGO:05500310.5ACTC1, PDGFRA
2muscle filament slidingGO:03004910.5ACTC1, DES, VIM
3positive regulation of phospholipase C activityGO:01086310.2KIT, PDGFRA

Molecular functions related to Leiomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1S100 protein bindingGO:04454810.5S100A1, S100B
2p53 bindingGO:00203910.5SMARCB1, MUC1, MDM2
3identical protein bindingGO:04280210.3VIM, S100B, S100A1, MDM2, DES

Products for genes affiliated with Leiomyosarcoma

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Sources for Leiomyosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet