MCID: LMY004
MIFTS: 62

Leiomyosarcoma malady

Cancer diseases category

Summaries for Leiomyosarcoma

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8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Leiomyosarcoma is a rare cancerous tumor that consists of smooth (involuntary) muscle cells. leiomyosarcoma is a type of sarcoma. it spreads through the blood stream and can affect the lungs, liver, blood vessels, or any other soft tissue in the body. it is most often found in the uterus or abdomen. last updated: 8/3/2010

MalaCards: Leiomyosarcoma, also known as leiomyomosarcoma, no subtype, is related to epithelioid leiomyosarcoma and leiomyoma. An important gene associated with Leiomyosarcoma is DES (desmin), and among its related pathways are Rho Family GTPases and PIP3 activates AKT signaling. The compounds paraffin and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include uterus, smooth muscle and liver, and related mouse phenotypes are behavior/neurological and normal.

Disease Ontology:8 A malignant smooth muscle cancer that can arise almost anywhere in the body, but is most common in the uterus, abdomen, or pelvis.

Wikipedia:63 Leiomyosarcoma (Gr. \"smooth muscle connective tissue tumor\"), aka LMS, is a malignant (cancer) smooth... more...

Aliases & Classifications for Leiomyosarcoma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

leiomyosarcoma 8 42 10 44 48 60
leiomyomosarcoma, no subtype 8
leiomyosarcoma nos 8
leiomyosarcomas 8


External Ids:

Disease Ontology8 DOID:1967
MeSH34 D007890
NCIt39 C3158
MESH via Orphanet35 D007890
SNOMED-CT via Orphanet57 443719001, 51549004
UMLS via Orphanet61 C0023269

Related Diseases for Leiomyosarcoma

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17GeneCards, 18GeneDecks
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Diseases in the Leiomyosarcoma family:

Inflammatory Leiomyosarcoma

Diseases related to Leiomyosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 316)
idRelated DiseaseScoreTop Affiliating Genes
1epithelioid leiomyosarcoma31.1ACTC1, DES, VIM
2leiomyoma30.9S100A1, PDGFRA, FH, DES, MYOG, PGR
3retroperitoneal leiomyosarcoma30.9SMARCB1
4sarcoma30.7VIM, CALD1, S100B, S100A1, PDGFRA, WT1
5endometrial stromal sarcoma30.4KIT, PGR, DES, PDGFRA, VIM, ACTC1
6gastrointestinal stromal tumor30.4PDGFRA, KIT
7smooth muscle tumor30.4VIM, CALD1, S100B, S100A1, DES, PGR
8retinoblastoma30.4WT1, MDM2, MYOG, ENO2, SMARCB1
9prostate leiomyosarcoma30.4PLCB2
10chondroma30.3PDGFRA
11liposarcoma30.3VIM, MDM2, DES
12paraganglioma30.2S100B, S100A1, FH, KIT, ENO2
13uterine carcinosarcoma30.2KIT
14rhabdomyosarcoma30.2S100B, S100A1, PDGFRA, WT1, MDM2, DES
15uterine fibroid30.2S100A1, FH, DES, MYOG, PGR
16fibrous histiocytoma30.2ACTC1, DES, S100B, VIM
17adenocarcinoma30.1VIM, WT1, MDM2, MUC1, PGR, ACTC1
18squamous cell carcinoma30.1VIM, S100A1, PDGFRA, MDM2, MUC1, ACTC1
19leiomyomatosis30.1FH, PGR
20synovial sarcoma30.0VIM, S100B, MDM2, DES, MUC1, KIT
21giant cell tumor30.0VIM, S100B, DES, MUC1, ACTC1
22osteosarcoma30.0MDM2, PDGFRA
23myoma30.0FH, PGR
24vascular cancer30.0CALD1
25glomus tumor29.9VIM, S100A1, DES, ACTC1
26fibrosarcoma29.9ACTC1, DES, MDM2, PDGFRA, VIM
27embryonal rhabdomyosarcoma29.9WT1, DES, MYOG, ACTC1
28colorectal cancer29.9PDGFRA, MDM2, MUC1
29epithelioid sarcoma29.9VIM, MUC1, SMARCB1
30malignant mesenchymoma29.9MYOG
31colon cancer29.9MDM2
32chondrosarcoma29.7VIM, S100B, S100A1, PDGFRA, MDM2, DES
33melanoma29.7VIM, S100B, S100A1, PDGFRA, MDM2, DES
34angiosarcoma29.7VIM, PDGFRA, MUC1, ACTC1
35alveolar rhabdomyosarcoma29.7WT1, MDM2, DES, MYOG, ENO2
36granular cell tumor29.7VIM, S100B, S100A1, DES, ENO2
37glioblastoma multiforme29.7S100B, PDGFRA, MDM2, KIT, SMARCB1
38lipoma29.7DES, MDM2, S100A1
39breast cancer29.7VIM, S100A1, MDM2, MUC1, PGR, ACTC1
40neurofibromatosis29.7S100B, PDGFRA, KIT, ENO2
41lymphangioleiomyomatosis29.7PGR, DES
42mesenchymal chondrosarcoma29.7VIM, DES, MUC1
43papillary carcinoma29.7ACTC1, PGR, MUC1, S100A1
44carney triad29.7PDGFRA, KIT
45kidney cancer29.7FH
46prostate cancer29.7ENO2, MDM2, FH, PDGFRA
47endometriosis29.7ACTC1, PGR, PDGFRA
48neurilemmoma29.7SMARCB1, ENO2
49bladder carcinoma29.7MDM2, FH
50pheochromocytoma29.7ENO2, FH

Graphical network of the top 20 diseases related to Leiomyosarcoma:



Diseases related to leiomyosarcoma

Clinical Features for Leiomyosarcoma

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Drugs & Therapeutics for Leiomyosarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Leiomyosarcoma

Drug clinical trials:

Search ClinicalTrials for Leiomyosarcoma

Search NIH Clinical Center for Leiomyosarcoma

Search CenterWatch for Leiomyosarcoma

Genetic Tests for Leiomyosarcoma

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Anatomical Context for Leiomyosarcoma

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32MalaCards
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MalaCards organs/tissues related to Leiomyosarcoma:

32
Uterus, Smooth muscle, Liver, Lung, Breast, Bone, Colon, Thyroid, Pancreas, Lymph node, Heart, Cervix, Kidney, Skin, Prostate, Tongue, Ovary, Small intestine, Adrenal gland, Endothelial, Spinal cord, Skeletal muscle, Brain, Testes, Tonsil, Myeloid, Testis

Animal Models for Leiomyosarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Leiomyosarcoma:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538611.0PDGFRA, S100A1, S100B, VIM, MDM2, DES
2MP:000287311.0S100B, S100A1, PDGFRA, WT1, MDM2, MYOG
3MP:000537611.0PDGFRA, FH, DES, MYOG, PGR, PLCB2
4MP:000538511.0WT1, PDGFRA, S100A1, VIM, MDM2, DES
5MP:000538410.9MDM2, WT1, PDGFRA, VIM, PGR, GPSM3
6MP:001076810.9WT1, FH, PDGFRA, CALD1, VIM, MDM2
7MP:000536910.8ACTC1, MDM2, WT1, PDGFRA
8MP:000538710.8PDGFRA, WT1, MDM2, PGR, GPSM3, PLCB2
9MP:000538010.6VIM, PDGFRA, WT1, MDM2, MYOG, PGR
10MP:001077110.6S100B, PDGFRA, MDM2, MYOG, PLCB2
11MP:000200610.4PDGFRA, MDM2, MUC1, PGR, KIT, SMARCB1

Publications for Leiomyosarcoma

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50PubMed
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Articles related to Leiomyosarcoma:

(show top 50)    (show all 986)
idTitleAuthorsYear
1
The uncovered story of leiomyosarcoma of the cervix: a rare case report and review of literature. (23519508)
2013
2
Long lasting clinical response to chemotherapy for advanced uterine leiomyosarcoma: a case report. (23347560)
2013
3
Primary low grade intratesticular leiomyosarcoma: case report and review of the literature. (24022314)
2013
4
Tumour-to-tumour metastasis of laryngeal leiomyosarcoma to an axillary hibernoma. (23609169)
2013
5
Tonsillar leiomyosarcoma. (24220466)
2013
6
Analysis of molecular cytogenetic alterations in uterine leiomyosarcoma by array-based comparative genomic hybridization. (22419440)
2012
7
Leiomyosarcoma leptomeningeal brain metastases. (24029094)
2012
8
Leiomyosarcoma of the sigmoid colon with multiple liver metastases and gastric cancer: a case report. (22849696)
2012
9
Primary leiomyosarcoma of bone: analysis of prognosis. (22550421)
2012
10
Conjunctival leiomyosarcoma. (21718409)
2012
11
It's not just who you are, it's also where you are: the cutaneous leiomyosarcoma dilemma. (22324176)
2012
12
Leiomyosarcoma of the inferior vena cava in a patient with double inferior vena cava. (22717359)
2012
13
Leiomyosarcoma with partial rhabdomyoblastic differentiation: first case report of primary cardiac origin. (21329505)
2011
14
Vascularity of nongynecological leiomyosarcoma depends on colony-stimulating factor 1 but not on vascular endothelial growth factor. (21839060)
2011
15
Choroidal metastasis from primary pulmonary leiomyosarcoma. (22452689)
2011
16
A rare tumor of the female genital tract: primary ovarian leiomyosarcoma. (21061129)
2011
17
The treatment of uterine leiomyosarcoma: clinical outcomes of 18 cases and the effectiveness of chemotherapy. (22335027)
2011
18
Case Report of Suspected Rhabdomyolysis during Treatment with Trabectedin in a Patient with Metastatic Leiomyosarcoma. (21611101)
2010
19
Myxoid leiomyosarcoma of the uterus: a diagnostic challenge. (20882892)
2010
20
Leiomyosarcoma of the inferior vena cava: a case report and review of the literature. (20178598)
2010
21
Unusually young age distribution of primary hepatic leiomyosarcoma: case series and review of the adult literature. (20594305)
2010
22
Uterine composite tumor composed of leiomyosarcoma and embryonal rhabdomyosarcoma with immature cartilage. (19483631)
2009
23
Coordinate expression of colony-stimulating factor-1 and colony-stimulating factor-1-related proteins is associated with poor prognosis in gynecological and nongynecological leiomyosarcoma. (19443701)
2009
24
Leiomyosarcoma of the hypopharynx: a case report. (18258399)
2008
25
Epithelioid leiomyosarcoma with rhabdoid features. (17943409)
2007
26
Cutaneous leiomyosarcoma, trichoblastoma, and syringocystadenoma papilliferum arising from nevus sebaceus. (17343592)
2007
27
Cutaneous leiomyosarcoma with myxoid alteration arising in a setting of multiple cutaneous smooth muscle neoplasms. (16972948)
2006
28
Prognoses and prognostic factors of carcinosarcoma, endometrial stromal sarcoma and uterine leiomyosarcoma: a comparison with uterine endometrial adenocarcinoma. (17690557)
2006
29
Retroperitoneal leiomyosarcoma infiltrating the inferior vena cava (IVC)--a case report. (16512470)
2005
30
Uterine leiomyosarcomas express KIT protein but lack mutation(s) in exon 9 of c-KIT. (16039311)
2005
31
Uterine smooth-muscle tumor of uncertain malignant potential metastasizing to the humerus as a high-grade leiomyosarcoma. (15350379)
2004
32
Oral leiomyosarcoma: review of the literature and report of two cases with assessment of the prognostic and diagnostic significance of immunohistochemical and molecular markers. (11854069)
2002
33
Peritoneal washing cytology findings of disseminated myxoid leiomyosarcoma of uterus: report of a case with emphasis on possible differential diagnosis. (12112816)
2002
34
Myxoid leiomyosarcoma of the gizzard in a broiler chicken. (11922347)
2002
35
Metastatic cutaneous leiomyosarcoma from primary neoplasm of the mesentery. (11703527)
2001
36
Gastrointestinal stromal tumors, intramural leiomyomas, and leiomyosarcomas in the rectum and anus: a clinicopathologic, immunohistochemical, and molecular genetic study of 144 cases. (11688571)
2001
37
Epithelioid leiomyosarcoma with osteoclast-like giant cells in the rectum. (10705403)
2000
38
Primary orbital leiomyoma and leiomyosarcoma. (10202288)
1999
39
Gastric leiomyosarcoma presenting as a sentinel hemorrhage. (10578561)
1999
40
Epithelioid lymphangioleiomyomatosis-like tumour of the uterus in a patient without tuberous sclerosis: a lesion mimicking epithelioid leiomyosarcoma. (9726062)
1998
41
Molecular characterization and liposomal transfection of a p53-mutated cell line established from a poorly differentiated leiomyosarcoma. (9664117)
1998
42
Epithelioid leiomyosarcoma of the larynx. (9702545)
1998
43
Analysis of Ki-ras, p53, and MDM2 genes in uterine leiomyomas and leiomyosarcomas. (9159347)
1997
44
Primary multiple epithelioid leiomyosarcoma of the liver. (8975973)
1996
45
Leiomyosarcoma in leiomyomatosis of the small intestine. (7971636)
1994
46
Uterine myxoid leiomyosarcoma and CYVADIC-etoposide therapy. (7806003)
1994
47
Two autopsy cases of primary leiomyosarcoma of the liver. Superiority of muscle-specific actin immunoreactivity in diagnosis. (1950562)
1991
48
Retroperitoneal leiomyosarcoma. (3661002)
1987
49
A comparative ultrastuctural study of leiomyosarcoma, cellular leiomyoma, and leiomyoma of the uterus. (5111736)
1971
50
Leiomyoma and leiomyosarcoma of the small intestine. Value of selective angiography]. (5503857)
1970

Genetic Variations for Leiomyosarcoma

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Expression for genes affiliated with Leiomyosarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Leiomyosarcoma

Search GEO for disease gene expression data for Leiomyosarcoma.

Pathways for genes affiliated with Leiomyosarcoma

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51QIAGEN, 53Reactome, 37NCBI BioSystems Database, 4Cell Signaling Technology
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Compounds for genes affiliated with Leiomyosarcoma

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44Novoseek, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB
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Compounds related to Leiomyosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
1paraffin4411.3KIT, PGR, MUC1, VIM, S100B, S100A1
2retinoic acid44 2412.3DES, WT1, PDGFRA, VIM, S100B, MUC1
3vegf4411.3MYOG, ENO2, VIM, ACTC1, KIT, PGR
4progesterone44 59 28 11 2415.3ENO2, ACTC1, KIT, PGR, MUC1, DES
5testosterone44 59 11 2414.3MDM2, WT1, S100B, MYOG, MUC1, PGR
6tyrosine4411.3KIT, ENO2, ACTC1, MUC1, MYOG, DES
7calcium44 49 11 2414.2PDGFRA, DES, MYOG, MUC1, PLCB2, S100A1
8cysteine4411.2VIM, S100B, WT1, MDM2, DES, MYOG
9hematoxylin4411.2VIM, DES, MUC1, KIT, ACTC1, ENO2
10b 7234411.2ACTC1, MUC1, DES, WT1, S100A1, S100B
11nitric oxide44 11 2413.1ENO2, KIT, MUC1, MYOG, DES, WT1
12formaldehyde44 2412.1ENO2, VIM, KIT, MUC1, DES, S100B
13s 1004411.1S100B, ENO2, ACTC1, MUC1, DES, VIM
14imatinib44 49 1113.1PDGFRA, KIT, S100B, DES, MDM2, ACTC1
15thymidine44 2412.1WT1, S100B, MDM2, DES, PDGFRA, MUC1
16mucicarmine4411.1DES, S100A1, MUC1, S100B, VIM, ACTC1
17ribonucleic acid4411.1ACTC1, KIT, PGR, MUC1, MYOG, WT1
18reticulin4411.1VIM, ACTC1, S100B, MUC1, DES
19iron44 2412.1ENO2, S100A1, ACTC1, VIM, S100B, MDM2
20steroid4411.1WT1, MDM2, MYOG, DES, RASD1, ACTC1
21toluidine4411.1ENO2, S100A1, KIT, DES, VIM
22methotrexate44 49 1113.0MUC1, MDM2, VIM, PGR, ENO2, KIT
23orcein4411.0VIM, S100B, DES, ACTC1
24aspartate4411.0ENO2, PDGFRA, FH, MDM2, PGR
25glycogen44 2412.0ACTC1, KIT, MDM2
26biotin44 11 2413.0VIM, S100A1, DES, MUC1, ACTC1
27creatinine4411.0WT1, ACTC1, FH
28adriamycin4411.0DES, MUC1, PGR, MDM2, VIM
29doxorubicin44 49 1113.0MDM2, KIT, PGR, DES, WT1, VIM
30bromodeoxyuridine4411.0ENO2, MYOG, S100B, DES, VIM
31dexamethasone44 49 28 1114.0ENO2, S100B, MDM2, RASD1
32oxygen44 2411.9FH, MYOG, DES, MDM2, MUC1, S100B
33actomyosin4410.9CALD1, S100A1, VIM, ACTC1
34estrogen4410.9MYOG
35hyaluronic acid44 2411.9VIM, ENO2, WT1, DES, MUC1
36eosin4410.9MUC1, VIM, S100B
37forskolin44 49 1112.9WT1, VIM, ENO2, MYOG, S100B, MUC1
38proline4410.9DES, MDM2, WT1, FH, S100B, VIM
39trastuzumab44 49 1112.9MDM2, PGR, MUC1, KIT
40acetylcholine44 49 28 11 2414.9ENO2, MYOG, S100A1
412-methoxyethanol4410.8ACTC1, S100A1, VIM
42lactate4410.8ENO2, DES, FH, S100B, VIM, KIT
43glucose4410.8ACTC1, MUC1, MYOG
44progestin4410.7PGR, DES, VIM, MUC1
45glutamine4410.7ENO2, WT1
46etoposide44 49 59 1113.7VIM, S100B, WT1, MDM2, ENO2
4712-o-tetradecanoylphorbol 13-acetate4410.6MYOG, DES, WT1, VIM, MUC1
48paclitaxel44 49 1112.6PGR, MDM2, S100B
49adenylate4410.6ENO2, MYOG, DES, S100B, VIM, PGR
50vincristine44 49 1112.3MDM2, WT1, VIM, KIT

GO Terms for genes affiliated with Leiomyosarcoma

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16Gene Ontology
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Biological processes related to Leiomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cardiac myofibril assemblyGO:05500310.5ACTC1, PDGFRA
2muscle filament slidingGO:03004910.5ACTC1, DES, VIM
3positive regulation of phospholipase C activityGO:01086310.2KIT, PDGFRA

Molecular functions related to Leiomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1S100 protein bindingGO:04454810.5S100A1, S100B
2p53 bindingGO:00203910.5SMARCB1, MUC1, MDM2
3identical protein bindingGO:04280210.3VIM, S100B, S100A1, MDM2, DES

Products for genes affiliated with Leiomyosarcoma

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Sources for Leiomyosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet