MCID: LMY004
MIFTS: 64

Leiomyosarcoma malady

Rare diseases, Cancer diseases categories
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Summaries for Leiomyosarcoma

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8Disease Ontology, 43NIH Rare Diseases, 65Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Leiomyosarcoma is a rare cancerous tumor that consists of smooth (involuntary) muscle cells. leiomyosarcoma is a type of sarcoma. it spreads through the blood stream and can affect the lungs, liver, blood vessels, or any other soft tissue in the body. it is most often found in the uterus or abdomen. last updated: 8/3/2010

MalaCards: Leiomyosarcoma, also known as leiomyomosarcoma, no subtype, is related to epithelioid leiomyosarcoma and retroperitoneal leiomyosarcoma. An important gene associated with Leiomyosarcoma is DES (desmin), and among its related pathways are Aurora B signaling and Nuclear signaling by ERBB4. The compounds toluidine and eosin have been mentioned in the context of this disorder. Affiliated tissues include uterus, smooth muscle and liver, and related mouse phenotypes are limbs/digits/tail and renal/urinary system.

Disease Ontology:8 A malignant smooth muscle cancer that can arise almost anywhere in the body, but is most common in the uterus, abdomen, or pelvis.

Wikipedia:65 Leiomyosarcoma (Gr. \"smooth muscle connective tissue tumor\"), also referred to as LMS, is a malignant... more...

Aliases & Classifications for Leiomyosarcoma

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 62UMLS, 40NCIt, 35MeSH, 58SNOMED-CT, 36MESH via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Orphanet: 49 
Rare tumors


Aliases & Descriptions:

leiomyosarcoma 8 43 10 45 49 62
leiomyomosarcoma, no subtype 8
leiomyosarcoma nos 8
leiomyosarcomas 8


External Ids:

Disease Ontology8 DOID:1967
NCIt40 C3158
MeSH35 D007890
MESH via Orphanet36 D007890
SNOMED-CT via Orphanet59 443719001, 51549004
UMLS via Orphanet63 C0023269

Related Diseases for Leiomyosarcoma

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17GeneCards, 18GeneDecks
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Diseases in the Leiomyosarcoma family:

Inflammatory Leiomyosarcoma

Diseases related to Leiomyosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 297)
idRelated DiseaseScoreTop Affiliating Genes
1epithelioid leiomyosarcoma31.3ACTC1, VIM, DES
2retroperitoneal leiomyosarcoma31.1SMARCB1
3leiomyoma30.8PGR, DES, VIM, ACTC1, FH, PDGFRA
4gastrointestinal stromal tumor30.6PDGFRA, KIT
5chondroma30.6PDGFRA
6endometrial stromal sarcoma30.5KIT, PDGFRA, ACTC1, VIM, PGR, DES
7liposarcoma30.5MDM2, VIM, DES
8smooth muscle tumor30.4KIT, S100B, ACTC1, VIM, PGR, DES
9paraganglioma30.4FH, S100B, KIT
10uterine fibroid30.4PGR, FH
11sarcoma30.3WT1, MDM2, KIT, S100B, PDGFRA, ACTC1
12leiomyomatosis30.3PGR, FH
13fibrous histiocytoma30.3DES, VIM, ACTC1, S100B
14myoma30.2FH, PGR
15glomus tumor30.1ACTC1, VIM, DES
16adenocarcinoma30.0WT1, MDM2, ACTC1, MUC1, VIM, PGR
17embryonal rhabdomyosarcoma30.0DES, ACTC1, WT1
18synovial sarcoma30.0DES, VIM, MUC1, S100B, KIT, MDM2
19giant cell tumor30.0DES, VIM, MUC1, ACTC1, S100B
20rhabdomyosarcoma29.9DES, SMARCB1, WT1, MDM2, S100B, PDGFRA
21kidney cancer29.9FH
22fibrosarcoma29.9DES, VIM, ACTC1, PDGFRA, MDM2
23cystadenocarcinoma29.9MUC1
24lymphangioleiomyomatosis29.9DES, PGR
25carney triad29.9PDGFRA, KIT
26neurilemmoma29.8SMARCB1
27granular cell tumor29.8DES, VIM, S100B
28lipoma29.8MDM2, DES
29dedifferentiated liposarcoma29.8DES, KIT, MDM2
30uterine sarcoma29.8DES, KIT, MDM2
31papillary carcinoma29.8PGR, MUC1, ACTC1
32endometriosis29.8PGR, ACTC1, PDGFRA
33neurofibromatosis29.8PDGFRA, S100B, KIT
34desmoid tumor29.8DES, ACTC1, PDGFRA, KIT
35angiosarcoma29.7VIM, MUC1, ACTC1, PDGFRA
36breast cancer29.7PGR, VIM, MUC1, ACTC1, MDM2
37ovarian cancer29.7PGR, MUC1, PDGFRA, MDM2
38chondrosarcoma29.6DES, VIM, MUC1, PDGFRA, S100B, MDM2
39glioblastoma multiforme29.6SMARCB1, PDGFRA, S100B, KIT, MDM2
40melanoma29.6DES, VIM, ACTC1, PDGFRA, S100B, KIT
41gastric leiomyosarcoma10.7
42cutaneous leiomyosarcoma10.7
43myxoid leiomyosarcoma10.7
44pulmonary artery leiomyosarcoma10.5
45hepatitis10.4
46pancreatitis10.3
47retinoblastoma10.3
48inflammatory leiomyosarcoma10.3
49thyroiditis10.3
50vulvar leiomyosarcoma10.3

Graphical network of the top 20 diseases related to Leiomyosarcoma:



Diseases related to leiomyosarcoma

Symptoms for Leiomyosarcoma

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Drugs & Therapeutics for Leiomyosarcoma

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Leiomyosarcoma

Search NIH Clinical Center for Leiomyosarcoma

Genetic Tests for Leiomyosarcoma

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Anatomical Context for Leiomyosarcoma

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33MalaCards
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MalaCards organs/tissues related to Leiomyosarcoma:

33
Uterus, Smooth muscle, Liver, Lung, Breast, Bone, Colon, Pancreas, Lymph node, Thyroid, Heart, Kidney, Cervix, Skin, Prostate, Small intestine, Ovary, Tongue, Endothelial, Adrenal gland, Brain, Spinal cord, Skeletal muscle, Myeloid, Testis, Testes, Tonsil

Animal Models for Leiomyosarcoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Leiomyosarcoma:

37 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.7MDM2, KIT, PDGFRA, PGR
2MP:00053678.2FH, PDGFRA, KIT, MDM2, WT1
3MP:00107718.1PGR, MUC1, PDGFRA, S100B, KIT, MDM2
4MP:00053867.9DES, PGR, VIM, PDGFRA, S100B, KIT
5MP:00030127.9PGR, MUC1, PDGFRA, KIT, MDM2, WT1
6MP:00053797.9PGR, MUC1, PDGFRA, KIT, WT1
7MP:00053707.8SMARCB1, MUC1, KIT, MDM2, WT1
8MP:00020067.7SMARCB1, PGR, MUC1, PDGFRA, KIT, MDM2
9MP:00053817.7SMARCB1, MUC1, PDGFRA, KIT, MDM2
10MP:00053697.6WT1, DES, PGR, VIM, ACTC1, PDGFRA
11MP:00028737.3PGR, MUC1, ACTC1, PDGFRA, S100B, KIT
12MP:00053807.3SMARCB1, PGR, VIM, PDGFRA, KIT, MDM2
13MP:00053897.2SMARCB1, PGR, VIM, PDGFRA, KIT, MDM2
14MP:00053977.2SMARCB1, PGR, VIM, PDGFRA, KIT, MDM2
15MP:00053877.1SMARCB1, PGR, VIM, PDGFRA, KIT, MDM2
16MP:00053787.1SMARCB1, VIM, ACTC1, PDGFRA, KIT, MDM2
17MP:00053856.8DES, SMARCB1, PGR, VIM, ACTC1, PDGFRA
18MP:00053846.7SMARCB1, PGR, VIM, ACTC1, FH, PDGFRA
19MP:00053766.5DES, SMARCB1, PGR, VIM, MUC1, ACTC1
20MP:00107686.4DES, SMARCB1, PGR, VIM, ACTC1, FH

Publications for Leiomyosarcoma

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52PubMed
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Articles related to Leiomyosarcoma:

(show top 50)    (show all 975)
idTitleAuthorsYear
1
Laryngeal leiomyosarcoma, a case report and review of articles. (24303449)
2013
2
Adjuvant therapy for high-grade, uterus-limited leiomyosarcoma: results of a phase 2 trial (SARC 005). (23335221)
2013
3
External validation of a prognostic nomogram for overall survival in women with uterine leiomyosarcoma. (23456762)
2013
4
Recurrent leiomyosarcoma presenting as malignant arterial tumor thrombus. (24371672)
2013
5
Primary leiomyosarcoma of the thyroid. (23833760)
2013
6
Near total occlusion of the main pulmonary artery and destruction of pulmonary valve by leiomyosarcoma. (23223120)
2013
7
Primary adrenal leiomyosarcoma: a case report with immunohistochemical study and review of literature. (23575089)
2013
8
Cell cycle regulatory markers in uterine atypical leiomyoma and leiomyosarcoma: immunohistochemical study of 68 cases with clinical follow-up. (23552380)
2013
9
Leiomyosarcoma after hysteroscopic myomectomy: a case report. (23327066)
2012
10
Intracranial dural metastasis from uterine leiomyosarcoma with orbital extension. (22231469)
2012
11
Leiomyosarcoma of the inferior vena cava extending into the right atrium. A rare differential diagnosis of a right atrial tumor with fatal outcome. (22430283)
2012
12
Case report: leiomyosarcoma of the parapharyngeal space. (22829041)
2012
13
Topoisomerase IIalpha activity and tumor cell proliferation level from the degree of bromodeoxyuridine label in uterine body leiomyosarcoma]. (21506336)
2011
14
Potential role of LMP2 as tumor-suppressor defines new targets for uterine leiomyosarcoma therapy. (22355695)
2011
15
CSF1 expression in nongynecological leiomyosarcoma is associated with increased tumor angiogenesis. (21854753)
2011
16
Phase II study of sunitinib malate, a multitargeted tyrosine kinase inhibitor in patients with relapsed or refractory soft tissue sarcomas. Focus on three prevalent histologies: leiomyosarcoma, liposarcoma and malignant fibrous histiocytoma. (21154746)
2011
17
Successful surgical management of a recurrent leiomyosarcoma of the inferior vena cava. (21283976)
2011
18
Cutaneous leiomyosarcoma originating in a symplastic pilar leiomyoma: a rare occurrence and potential diagnostic pitfall. (19780873)
2011
19
Leiomyosarcoma with partial rhabdomyoblastic differentiation: first case report of primary cardiac origin. (21329505)
2011
20
Leiomyosarcoma of the temporal bone. (21879494)
2011
21
Leiomyosarcoma of the inferior vena cava: clinicopathologic study of 40 cases. (20463568)
2010
22
Case Report of Suspected Rhabdomyolysis during Treatment with Trabectedin in a Patient with Metastatic Leiomyosarcoma. (21611101)
2010
23
Surgical resection of the inferior vena cava for leiomyosarcoma. (20494550)
2010
24
A case of high-grade leiomyosarcoma of the bladder with delayed onset and very poor prognosis. (20302611)
2010
25
Mice-lacking LMP2, immuno-proteasome subunit, as an animal model of spontaneous uterine leiomyosarcoma. (21203912)
2010
26
Leiomyosarcoma uteri in a white woman. (20418648)
2010
27
Primary hepatic leiomyosarcoma in a young man after Hodgkin's disease: diagnostic pitfalls and therapeutic challenge. (19688980)
2009
28
Gastric leiomyosarcoma manifesting peculiar findings: radiological-pathological correlation. (19432672)
2009
29
Epithelioid leiomyosarcoma with rhabdoid features. (17943409)
2007
30
A high-grade uterine leiomyosarcoma with human chorionic gonadotropin production. (16810064)
2006
31
Oncogenic property of acrogranin in human uterine leiomyosarcoma: direct evidence of genetic contribution in in vivo tumorigenesis. (16533762)
2006
32
p53, epidermal growth factor, and platelet-derived growth factor in uterine leiomyosarcoma and leiomyomas. (16681772)
2006
33
Bcl-2 receptor expression in patients with uterine smooth muscle tumors: an immunohistochemical analysis comparing leiomyoma, uterine smooth muscle tumor of uncertain malignant potential, and leiomyosarcoma. (15051039)
2004
34
Expression of matrix metalloproteinases in patients with uterine smooth muscle tumors: an immunohistochemical analysis of MMP-1 and MMP-2 protein expression in leiomyoma, uterine smooth muscle tumor of uncertain malignant potential, and leiomyosarcoma. (15051038)
2004
35
Ki-67 expression in patients with uterine leiomyomas, uterine smooth muscle tumors of uncertain malignant potential (STUMP) and uterine leiomyosarcomas (LMS). (15488127)
2004
36
Primary paratesticular epithelioid leiomyosarcoma. (12740499)
2003
37
Low frequency of somatic mutations in the FH/multiple cutaneous leiomyomatosis gene in sporadic leiomyosarcomas and uterine leiomyomas. (12177782)
2002
38
Vulvar leiomyosarcoma: a case report in a Nigerian woman. (12384866)
2002
39
Retroperitoneal leiomyomas: a clinicopathologic and immunohistochemical study of 56 cases with a comparison to retroperitoneal leiomyosarcomas. (11684951)
2001
40
Myxoid leiomyosarcoma of the left atrium: a rare malignancy of the heart and its comparison with atrial myxoma. (11264566)
2001
41
Progesterone receptors in gastric leiomyosarcoma. (9840313)
1998
42
Myxoid leiomyosarcoma of the uterus: a case report and review of the literature. (9811191)
1998
43
Sclerotic primary cutaneous leiomyosarcoma. (8599440)
1995
44
Pulmonary myxoid leiomyosarcoma. (8581153)
1995
45
Hyponatremic hypertensive syndrome and massive proteinuria in a patient with renin-producing leiomyosarcoma. (8023829)
1994
46
Gastric leiomyosarcoma. (1609721)
1992
47
Leiomyosarcomas have a poorer prognosis than mixed mesodermal tumours when adjusting for known prognostic factors: the result of a retrospective study of 423 cases of uterine sarcoma. (1326319)
1992
48
Intermediate and fine cytofilaments in cutaneous and subcutaneous leiomyosarcomas. (1716444)
1991
49
Uterine malignancy developing after long term use of IUCD additional report of 2 cases: endometrial stromal sarcoma and leiomyosarcoma. (2597086)
1989
50
Occurrence of cicatricial pemphigoid and leiomyosarcoma in a psoriatic patient. (3891438)
1985

Variations for Leiomyosarcoma

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Expression for genes affiliated with Leiomyosarcoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Leiomyosarcoma

Search GEO for disease gene expression data for Leiomyosarcoma.

Pathways for genes affiliated with Leiomyosarcoma

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50PathCards, 38NCBI BioSystems Database, 55Reactome, 5Cell Signaling Technology, 30KEGG, 53QIAGEN
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Pathways related to Leiomyosarcoma according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Signaling by Aurora kinases38
Aurora C signaling38
9.9DES, VIM
2
Show member pathways
9.7S100B, PGR
39.6ACTC1, VIM, DES
4
Show member pathways
9.6ACTC1, VIM, DES
59.3ACTC1, PDGFRA, KIT
69.1MDM2, PDGFRA, VIM
7
Show member pathways
9.1PDGFRA, KIT, MDM2
89.1MDM2, KIT, PDGFRA
98.8WT1, MDM2, PDGFRA
108.8FH, PDGFRA, KIT, MDM2
11
Show member pathways
8.3MDM2, KIT, S100B, PDGFRA, PGR
12
Show member pathways
8.1DES, VIM, MUC1, PDGFRA, KIT, MDM2

Compounds for genes affiliated with Leiomyosarcoma

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45Novoseek, 24HMDB, 11DrugBank, 29IUPHAR, 51PharmGKB, 61Tocris Bioscience
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Compounds related to Leiomyosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1toluidine459.9DES, VIM, KIT
2eosin459.7VIM, MUC1, S100B
3orcein459.6VIM, S100B, DES, ACTC1
4biotin45 24 1111.5VIM, DES, ACTC1, MUC1
5progestin459.4MUC1, VIM, DES, PGR
6dihydrotestosterone45 29 24 1112.3VIM, DES, PGR, MUC1
7s 100459.2VIM, MUC1, S100B, ACTC1, DES
8reticulin459.2ACTC1, S100B, VIM, DES, MUC1
9mucicarmine459.2MUC1, S100B, ACTC1, VIM, DES
10trastuzumab45 51 1111.2PGR, KIT, MDM2, MUC1
11vincristine45 51 1111.0WT1, MDM2, KIT, VIM
12lactate459.0S100B, FH, VIM, DES, KIT
13hyaluronic acid45 2410.0WT1, MUC1, VIM, DES
14adriamycin458.9DES, VIM, MDM2, MUC1, PGR
15iron45 249.9DES, ACTC1, S100B, MDM2, VIM
16actinomycin d458.9DES, VIM, MUC1, KIT, MDM2
17folate458.9PDGFRA, VIM, PGR, MUC1
18paclitaxel45 51 1110.9PGR, S100B, MDM2, KIT, VIM
19methotrexate51 45 1110.9KIT, VIM, MDM2, PGR, MUC1
20hematoxylin458.9KIT, ACTC1, DES, VIM, MUC1, S100B
21formaldehyde45 249.9MUC1, VIM, DES, ACTC1, S100B, KIT
22estradiol45 24 1110.8MDM2, MUC1, VIM, PGR, DES
23valine458.8S100B, VIM, MDM2, KIT
245fluorouracil458.8MDM2, KIT, MUC1, PGR
25ribonucleic acid458.8PGR, WT1, MUC1, ACTC1, KIT
26glutamine458.7PGR, WT1, KIT, S100B, VIM
27b 723458.6ACTC1, MUC1, WT1, S100B, VIM, DES
28dexamethasone45 51 29 1111.5PGR, MUC1, MDM2, S100B, VIM, ACTC1
29doxorubicin45 51 1110.5PGR, VIM, DES, MDM2, WT1, KIT
30glucose458.4MUC1, DES, ACTC1, KIT, FH, S100B
31proline458.4DES, VIM, WT1, S100B, FH, MDM2
32glycogen45 249.3ACTC1, DES, MDM2, VIM, MUC1, S100B
33oxygen45 249.3FH, S100B, DES, MDM2, ACTC1, MUC1
34cyclic amp45 249.2DES, VIM, MUC1, S100B, MDM2
35creatinine458.2DES, WT1, FH, ACTC1, MUC1, S100B
36nitric oxide45 24 1110.2KIT, WT1, DES, MUC1, S100B, MDM2
37threonine458.2KIT, MDM2, DES, WT1, S100B, MUC1
38aspartate458.1S100B, MDM2, KIT, PDGFRA, FH, VIM
39steroid458.1DES, ACTC1, MDM2, S100B, KIT, WT1
40imatinib45 51 1110.0WT1, MDM2, KIT, S100B, PDGFRA, ACTC1
41serine457.8DES, KIT, S100B, MUC1, WT1, MDM2
42thymidine45 248.8KIT, DES, MUC1, WT1, MDM2, S100B
43cysteine457.6MUC1, S100B, PGR, VIM, WT1, DES
44progesterone45 29 61 24 1111.4DES, KIT, S100B, ACTC1, MUC1, VIM
45testosterone45 61 24 1110.4PGR, VIM, MUC1, ACTC1, S100B, MDM2
46retinoic acid45 248.3MUC1, PGR, ACTC1, S100B, DES, VIM
47tyrosine457.1KIT, MDM2, WT1, ACTC1, S100B, MUC1
48paraffin456.8PGR, VIM, DES, WT1, MDM2, KIT
49vegf456.8WT1, PGR, MUC1, DES, ACTC1, PDGFRA
50estrogen456.8ACTC1, S100B, WT1, MDM2, KIT, PDGFRA

GO Terms for genes affiliated with Leiomyosarcoma

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16Gene Ontology
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Cellular components related to Leiomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:0057377.0WT1, MDM2, S100B, PDGFRA, FH, ACTC1

Biological processes related to Leiomyosarcoma according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1cardiac myofibril assemblyGO:0550039.9ACTC1, PDGFRA
2muscle filament slidingGO:0300499.9ACTC1, VIM, DES
3positive regulation of phospholipase C activityGO:0108639.9KIT, PDGFRA
4cell chemotaxisGO:0603269.6KIT, PDGFRA
5positive regulation of phosphatidylinositol 3-kinase activityGO:0435529.5KIT, PDGFRA
6male genitalia developmentGO:0305399.5WT1, PDGFRA
7adrenal gland developmentGO:0303259.4WT1, PDGFRA
8phosphatidylinositol-mediated signalingGO:0480159.3MDM2, KIT, PDGFRA
9fibroblast growth factor receptor signaling pathwayGO:0085439.3PDGFRA, KIT, MDM2
10Fc-epsilon receptor signaling pathwayGO:0380959.3PDGFRA, KIT, MDM2
11epidermal growth factor receptor signaling pathwayGO:0071739.2MDM2, KIT, PDGFRA
12positive regulation of cell proliferationGO:0082849.0PDGFRA, S100B, KIT, MDM2
13neurotrophin TRK receptor signaling pathwayGO:0480118.8MDM2, KIT, PDGFRA
14innate immune responseGO:0450878.7PDGFRA, S100B, KIT, MDM2

Molecular functions related to Leiomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane receptor protein tyrosine kinase activityGO:0047149.6KIT, PDGFRA
2scaffold protein bindingGO:0971109.4MDM2, VIM
3identical protein bindingGO:0428028.9MDM2, S100B, VIM, DES
4p53 bindingGO:0020398.7SMARCB1, MUC1, MDM2
5protein bindingGO:0055155.9WT1, DES, SMARCB1, PGR, VIM, MUC1

Products for genes affiliated with Leiomyosarcoma

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Sources for Leiomyosarcoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet