MCID: LMY004
MIFTS: 53

Leiomyosarcoma malady

Cancer category

Summaries for Leiomyosarcoma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Leiomyosarcoma is a rare cancerous tumor that consists of smooth (involuntary) muscle cells. leiomyosarcoma is a type of sarcoma. it spreads through the blood stream and can affect the lungs, liver, blood vessels, or any other soft tissue in the body. it is most often found in the uterus or abdomen. last updated: 8/3/2010

MalaCards: Leiomyosarcoma, also known as leiomyomosarcoma, no subtype, is related to epithelioid leiomyosarcoma and retroperitoneal leiomyosarcoma. An important gene associated with Leiomyosarcoma is DES (desmin), and among its related pathways are Rho Family GTPases and PIP3 activates AKT signaling. The compounds paraffin and retinoic acid have been mentioned in the context of this disorder. Related mouse phenotypes are behavior/neurological and normal.

Disease Ontology:8 A malignant smooth muscle cancer that can arise almost anywhere in the body, but is most common in the uterus, abdomen, or pelvis.

Wikipedia:64 Leiomyosarcoma (Gr. \"smooth muscle connective tissue tumor\"), aka LMS, is a malignant cancer of smooth... more...

Aliases & Classifications for Leiomyosarcoma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 36MESH via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

leiomyosarcoma 8 43 10 45 49 61
leiomyomosarcoma, no subtype 8
leiomyosarcoma nos 8
leiomyosarcomas 8


External Ids:

Disease Ontology8 DOID:1967
MeSH35 D007890
NCIt40 C3158
MESH via Orphanet36 D007890
SNOMED-CT via Orphanet58 443719001, 51549004
UMLS via Orphanet62 C0023269

Related Diseases for Leiomyosarcoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Leiomyosarcoma family:

inflammatory leiomyosarcoma

Diseases related to Leiomyosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 294)
idRelated DiseaseScoreTop Affiliating Genes
1epithelioid leiomyosarcoma31.1ACTC1, DES, VIM
2retroperitoneal leiomyosarcoma31.0SMARCB1
3endometrial stromal sarcoma30.5PGR, DES, PDGFRA, VIM, ACTC1, KIT
4gastrointestinal stromal tumor30.5KIT, PDGFRA
5uterine sarcoma30.5DES, MDM2, KIT
6smooth muscle tumor30.4ACTC1, PGR, DES, KIT, S100B, S100A1
7prostate leiomyosarcoma30.4PLCB2
8paraganglioma30.3S100B, ENO2, KIT, FH, S100A1
9carney triad30.3KIT, PDGFRA
10uterine carcinosarcoma30.3KIT
11uterine fibroid30.2FH, S100A1, DES, MYOG, PGR
12fibrous histiocytoma30.2ACTC1, S100B, DES, VIM
13adenocarcinoma30.2ACTC1, PGR, MUC1, MDM2, VIM, ENO2
14squamous cell carcinoma30.2ENO2, ACTC1, MUC1, MDM2, PDGFRA, S100A1
15synovial sarcoma30.1VIM, MDM2, DES, KIT, S100B, MUC1
16myoma30.1PGR, FH
17vascular cancer30.1CALD1
18colorectal cancer29.9PDGFRA, MDM2, MUC1
19alveolar rhabdomyosarcoma29.7MYOG, ENO2, DES, WT1, MDM2
20desmoid tumor29.7PDGFRA, ACTC1, KIT, DES
21angiosarcoma29.7VIM, PDGFRA, MUC1, ACTC1
22granular cell tumor29.7ENO2, S100A1, S100B, DES, VIM
23neurofibromatosis29.7S100B, ENO2, KIT, PDGFRA
24lymphangioleiomyomatosis29.7PGR, DES
25dedifferentiated liposarcoma29.7KIT, DES, MDM2
26papillary carcinoma29.7PGR, ACTC1, MUC1, S100A1
27bladder carcinoma29.7FH, MDM2
28pheochromocytoma29.7FH, ENO2
29acute leukemia29.7SMARCB1, KIT, WT1
30tuberous sclerosis29.7S100B, VIM
31gastric leiomyosarcoma10.8
32cutaneous leiomyosarcoma10.7
33myxoid leiomyosarcoma10.7
34uterus leiomyosarcoma10.7
35liver leiomyosarcoma10.5
36breast leiomyosarcoma10.5
37pulmonary artery leiomyosarcoma10.5
38colon leiomyosarcoma10.5
39bone leiomyosarcoma10.4
40lung leiomyosarcoma10.4
41pulmonary vein leiomyosarcoma10.4
42heart leiomyosarcoma10.4
43kidney leiomyosarcoma10.3
44small intestine leiomyosarcoma10.3
45inflammatory leiomyosarcoma10.3
46gallbladder leiomyosarcoma10.3
47vulvar leiomyosarcoma10.3
48larynx leiomyosarcoma10.3
49ovary leiomyosarcoma10.3
50mediastinum leiomyosarcoma10.3

Graphical network of the top 20 diseases related to Leiomyosarcoma:



Diseases related to leiomyosarcoma

Clinical Features for Leiomyosarcoma

Drugs & Therapeutics for Leiomyosarcoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Leiomyosarcoma

Drug clinical trials:

Search ClinicalTrials for Leiomyosarcoma

Search NIH Clinical Center for Leiomyosarcoma

Search CenterWatch for Leiomyosarcoma

Genetic Tests for Leiomyosarcoma

Anatomical Context for Leiomyosarcoma

Animal Models for Leiomyosarcoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Leiomyosarcoma

Sources:
51PubMed
See all sources

Articles related to Leiomyosarcoma:

(show top 50)    (show all 997)
idTitleAuthorsYear
1
Primary pulmonary leiomyosarcoma. (24263234)
2014
2
Pulmonary metastasis of uterine leiomyosarcoma presenting as centrilobular nodules with "tree-in-bud" pattern. (23602590)
2013
3
Diagnosis, prognosis, and management of leiomyosarcoma: recognition of anatomic variants. (23635801)
2013
4
Primary intracranial leiomyosarcoma. (24093144)
2013
5
Curcumin targets the AKT-mTOR pathway for uterine leiomyosarcoma tumor growth suppression. (23666561)
2013
6
Leiomyosarcoma of the soft palate. (23611325)
2013
7
Diagnosis and management of leiomyosarcoma arising from ovarian vein: case report and literature review. (22229846)
2012
8
Leiomyosarcoma of the base of the tongue and free edge of the epiglottis: a case report. (23176176)
2012
9
Leiomyosarcoma of the adrenal vein. (23127348)
2012
10
Immunohistochemical expression of estrogen and progesterone receptors and outcomes in patients with newly diagnosed uterine leiomyosarcoma. (22085894)
2012
11
Comparative gene expression profiling of benign and malignant lesions reveals candidate therapeutic compounds for leiomyosarcoma. (22919280)
2012
12
Pulmonary metastatic leiomyosarcoma invading the left atrium through the pulmonary veins. (23960699)
2012
13
Histopathologic prognostic factors in stage I leiomyosarcoma of the uterus: a detailed analysis of 27 cases. (21383611)
2011
14
"Low-grade leiomyosarcoma" and late-recurring smooth muscle tumors of the uterus: a heterogenous collection of frequently misdiagnosed tumors associated with an overall favorable prognosis relative to conventional uterine leiomyosarcomas. (21921786)
2011
15
Metastatic Primary Leiomyosarcoma of the Pancreas to the Liver: Report of a Surgically Treated Case. (21720738)
2011
16
Curcumin disrupts uterine leiomyosarcoma cells through AKT-mTOR pathway inhibition. (21450334)
2011
17
Multidetector CT appearance of leiomyosarcoma of the splenic vein. (21356533)
2011
18
The surgical management of a leiomyosarcoma of the submandibular gland in a 95-year-old patient. (21856190)
2011
19
Pulmonary leiomyosarcoma metastatic to the thyroid gland: case report and review of the literature. (21784409)
2011
20
Leiomyosarcoma of the inferior vena cava: clinicopathologic study of 40 cases. (20463568)
2010
21
Cardiac epithelioid leiomyosarcoma and the role of cardiac imaging in the differentiation of intracardiac masses. (20552587)
2010
22
Hepatocyte growth factor activator inhibitors (HAI-1 and HAI-2) are potential targets in uterine leiomyosarcoma. (20664929)
2010
23
Integrated proteomics and genomics analysis reveals a novel mesenchymal to epithelial reverting transition in leiomyosarcoma through regulation of slug. (20651304)
2010
24
Leiomyosarcoma of the broad ligament with osteoclast-like giant cells and rhabdoid cells. (20736768)
2010
25
Primary leiomyosarcoma of the right atrium: a case report and literature update. (20939891)
2010
26
Primary hepatic leiomyosarcoma in a young man after Hodgkin's disease: diagnostic pitfalls and therapeutic challenge. (19688980)
2009
27
Gastric leiomyosarcoma manifesting peculiar findings: radiological-pathological correlation. (19432672)
2009
28
Leiomyosarcoma of the renal pelvis. (19805970)
2009
29
Dedifferentiated chondrosarcoma arising in a solitary osteochondroma with leiomyosarcomatous component: a case report. (18196252)
2008
30
An unusual case of aldosterone- and norepinephrine-secreting retroperitoneal leiomyosarcoma. (18504372)
2008
31
Primary cutaneous leiomyosarcoma: a histological and immunohistochemical study of 4 cases. (18416331)
2007
32
Cutaneous metastatic malignant mixed mullerian tumour mimicking cutaneous leiomyosarcoma: a case report. (15491456)
2004
33
Leiomyosarcoma of the breast: a pathologic and comparative genomic hybridization study of two cases. (15104283)
2004
34
Unicentric Castleman's disease with leiomyosarcoma: a rare association. (14633090)
2003
35
Clinicopathological analysis of c-kit expression in carcinosarcomas and leiomyosarcomas of the uterine corpus. (14529656)
2003
36
Unusual pulmonary lesions: case 3. Pulmonary vein leiomyosarcoma presenting as a left atrial mass. (12039939)
2002
37
Epithelioid leiomyosarcoma of the uterine cervix. (11531304)
2001
38
Leiomyosarcoma as a second metachronous malignant neoplasm following colon adenocarcinoma. A case report and review of the literature. (18521306)
2001
39
Preoperative diagnosis of pancreatic leiomyosarcoma. (11128979)
2000
40
Nephrogenic diabetes insipidus in a dog with intestinal leiomyosarcoma. (10613214)
1999
41
Expression of myogenic marker proteins in human leiomyosarcoma. (9368594)
1997
42
Congenital peribronchial myofibroblastic tumor (so-called "congenital leiomyosarcoma"). A distinct neonatal lung lesion associated with nonimmune hydrops fetalis. (8415597)
1993
43
Myxoid leiomyosarcoma of the stomach: a case report. (1805049)
1991
44
Leiomyosarcoma of the larynx. Histological, immunohistochemical and ultrastructural study of a case with review of the literature]. (2053989)
1991
45
Renin-secreting retroperitoneal leiomyosarcoma: an unusual cause of hypertension. (2189028)
1990
46
Intermediate and fine filaments of vascular leiomyomas (angiomyoma), leiomyoma and leiomyosarcomas of large veins. (2751898)
1989
47
Pulmonary artery leiomyosarcoma treated surgically. (2424139)
1986
48
Carney's triad: gastric leiomyosarcoma, pulmonary chondroma and extra-adrenal paraganglioma in young females. (3028925)
1986
49
Myxoid leiomyosarcoma of the uterus. (6511163)
1984
50
Postradiation leiomyosarcoma of the orbit complicating bilateral retinoblastoma. (6626009)
1983

Genetic Variations for Leiomyosarcoma

Expression for genes affiliated with Leiomyosarcoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Leiomyosarcoma

Search GEO for disease gene expression data for Leiomyosarcoma.

Pathways for genes affiliated with Leiomyosarcoma

Sources:
52QIAGEN, 54Reactome, 38NCBI BioSystems Database, 4Cell Signaling Technology
See all sources

Compounds for genes affiliated with Leiomyosarcoma

Sources:
45Novoseek, 24HMDB, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 50PharmGKB
See all sources

Compounds related to Leiomyosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
1paraffin4511.3KIT, PGR, MUC1, VIM, S100B, S100A1
2retinoic acid45 2412.3DES, WT1, PDGFRA, VIM, S100B, MUC1
3vegf4511.3MYOG, ENO2, VIM, ACTC1, KIT, PGR
4progesterone45 60 29 11 2415.3ENO2, ACTC1, KIT, PGR, MUC1, DES
5testosterone45 60 11 2414.3MDM2, WT1, S100B, MYOG, MUC1, PGR
6tyrosine4511.3KIT, ENO2, ACTC1, MUC1, MYOG, DES
7calcium45 50 11 2414.2PDGFRA, DES, MYOG, MUC1, PLCB2, S100A1
8cysteine4511.2VIM, S100B, WT1, MDM2, DES, MYOG
9hematoxylin4511.2VIM, DES, MUC1, KIT, ACTC1, ENO2
10b 7234511.2ACTC1, MUC1, DES, WT1, S100A1, S100B
11nitric oxide45 11 2413.1ENO2, KIT, MUC1, MYOG, DES, WT1
12formaldehyde45 2412.1ENO2, VIM, KIT, MUC1, DES, S100B
13s 1004511.1S100B, ENO2, ACTC1, MUC1, DES, VIM
14imatinib45 50 1113.1PDGFRA, KIT, S100B, DES, MDM2, ACTC1
15thymidine45 2412.1WT1, S100B, MDM2, DES, PDGFRA, MUC1
16mucicarmine4511.1DES, S100A1, MUC1, S100B, VIM, ACTC1
17ribonucleic acid4511.1ACTC1, KIT, PGR, MUC1, MYOG, WT1
18reticulin4511.1VIM, ACTC1, S100B, MUC1, DES
19iron45 2412.1ENO2, S100A1, ACTC1, VIM, S100B, MDM2
20steroid4511.1WT1, MDM2, MYOG, DES, RASD1, ACTC1
21toluidine4511.1ENO2, S100A1, KIT, DES, VIM
22methotrexate45 50 1113.0MUC1, MDM2, VIM, PGR, ENO2, KIT
23orcein4511.0VIM, S100B, DES, ACTC1
24aspartate4511.0ENO2, PDGFRA, FH, MDM2, PGR
25glycogen45 2412.0ACTC1, KIT, MDM2
26biotin45 11 2413.0VIM, S100A1, DES, MUC1, ACTC1
27creatinine4511.0WT1, ACTC1, FH
28adriamycin4511.0DES, MUC1, PGR, MDM2, VIM
29doxorubicin45 50 1113.0MDM2, KIT, PGR, DES, WT1, VIM
30bromodeoxyuridine4511.0ENO2, MYOG, S100B, DES, VIM
31dexamethasone45 50 29 1114.0ENO2, S100B, MDM2, RASD1
32oxygen45 2411.9FH, MYOG, DES, MDM2, MUC1, S100B
33actomyosin4510.9CALD1, S100A1, VIM, ACTC1
34estrogen4510.9MYOG
35hyaluronic acid45 2411.9VIM, ENO2, WT1, DES, MUC1
36eosin4510.9MUC1, VIM, S100B
37forskolin45 50 1112.9WT1, VIM, ENO2, MYOG, S100B, MUC1
38proline4510.9DES, MDM2, WT1, FH, S100B, VIM
39trastuzumab45 50 1112.9MDM2, PGR, MUC1, KIT
40acetylcholine45 50 29 11 2414.9ENO2, MYOG, S100A1
412-methoxyethanol4510.8ACTC1, S100A1, VIM
42lactate4510.8ENO2, DES, FH, S100B, VIM, KIT
43glucose4510.8ACTC1, MUC1, MYOG
44progestin4510.7PGR, DES, VIM, MUC1
45glutamine4510.7ENO2, WT1
46etoposide45 50 60 1113.7VIM, S100B, WT1, MDM2, ENO2
4712-o-tetradecanoylphorbol 13-acetate4510.6MYOG, DES, WT1, VIM, MUC1
48paclitaxel45 50 1112.6PGR, MDM2, S100B
49adenylate4510.6ENO2, MYOG, DES, S100B, VIM, PGR
50vincristine45 50 1112.3MDM2, WT1, VIM, KIT

GO Terms for genes affiliated with Leiomyosarcoma

Sources:
16Gene Ontology
See all sources

Biological processes related to Leiomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cardiac myofibril assemblyGO:05500310.5ACTC1, PDGFRA
2muscle filament slidingGO:03004910.5ACTC1, DES, VIM
3positive regulation of phospholipase C activityGO:01086310.2KIT, PDGFRA

Molecular functions related to Leiomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1S100 protein bindingGO:04454810.5S100A1, S100B
2p53 bindingGO:00203910.5SMARCB1, MUC1, MDM2
3identical protein bindingGO:04280210.3VIM, S100B, S100A1, MDM2, DES

Products for genes affiliated with Leiomyosarcoma

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Sources for Leiomyosarcoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet