MCID: LSH001
MIFTS: 74

Leishmaniasis malady

Infectious diseases category

Summaries for Leishmaniasis

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8Disease Ontology, 42NIH Rare Diseases, 33MedlinePlus, 3CDC, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Leishmaniasis is a parasitic disease spread by the bite of infected sand flies. there are several different forms of leishmaniasis. the most common are cutaneous and visceral. the cutaneous type causes skin sores. the visceral type affects internal organs such as the spleen, liver, and bone marrow. people with this form usually have fever, weight loss, and an enlarged spleen and liver. leishmaniasis is found in parts of about 88 countries. most of these countries are in the tropics and subtropics. it is possible but very unlikely that you would get this disease in the united states. but you should be aware of it if you are traveling to the middle east or parts of central america, south america, asia, africa or southern europe. treatment is with medicines that contain antimony, a type of metal, or with strong antibiotics. the best way to prevent the disease is to protect yourself from sand fly bites: stay indoors from dusk to dawn, when sand flies are the most active wear long pants and long-sleeved shirts when outside use insect repellent and bed nets as needed centers for disease control and prevention

MalaCards: Leishmaniasis, also known as leishmaniasis, unspecified, is related to visceral leishmaniasis and cutaneous leishmaniasis. An important gene associated with Leishmaniasis is IFNG (interferon, gamma), and among its related pathways are Allograft rejection and Cytokine Network. The drugs ketoconazole and itraconazole and the compounds nitric oxide and vegf have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and spleen, and related mouse phenotypes are hematopoietic system and digestive/alimentary.

Disease Ontology:8 A parasitic protozoa infectious disease that involves infection caused by protozoan parasite of the genus leishmania, which is transmitted by the bite of sand fly (subfamily phlebotominae).

NIH Rare Diseases:42 Leishmaniasis is a parasitic disease spread by the bite of infected sand flies. there are several different forms of leishmaniasis. the most common are cutaneous and visceral. the cutaneous type causes skin sores. the visceral type affects internal organs such as the spleen, liver and bone marrow. people with this form usually have fever, weight loss, and an enlarged spleen and liver. visceral disease can be deadly without proper treatment. leishmaniasis is found in parts of the middle east, central america, south american, asia, africa, and southern europe. most of these countries are in the tropics and subtropics. it is possible but very unlikely to get this disease in the united states. last updated: 7/6/2011

CDC:3 Leishmaniasis is a parasitic disease that is found in parts of the tropics, subtropics, and southern Europe. It is classified as a Neglected Tropical Disease (NTD). Leishmaniasis is caused by infection with Leishmania parasites, which are spread by the bite of phlebotomine sand flies. There are several different forms of leishmaniasis in people. The most common forms are cutaneous leishmaniasis, which causes skin sores, and visceral leishmaniasis, which affects several internal organs (usually spleen, liver, and bone marrow).

Wikipedia:63 Leishmaniasis /ˌliːʃməˈnaɪəsɪs/ or leishmaniosis (/liːʃˌmeɪnɪˈoʊsɪs/ or... more...

Description from OMIM:46 608207

Aliases & Classifications for Leishmaniasis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 46OMIM, 33MedlinePlus, 60UMLS, 27ICD9CM, 34MeSH, 39NCIt, 56SNOMED-CT, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 35MESH via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Characteristics (Orphanet epidemiological data):

48
leishmaniasis:
Inheritance: Sporadic; Prevalence: 1-9/1000000; Age of onset: Variable


Aliases & Descriptions:

leishmaniasis 8 42 10 44 48 46 33 60
leishmaniasis, unspecified 8
leishmaniasis, cutaneous 60
cutaneous leishmaniasis 42
leishmaniasis, visceral 60
visceral leishmaniasis 42
leishmaniasis nos 8
kala-azar 42


External Ids:

Disease Ontology8 DOID:9065
ICD9CM27 085, 085.9
MeSH34 D007896
NCIt39 C34767
ICD10 via Orphanet26 B55.0, B55.1, B55.2 B55.9, more
SNOMED-CT via Orphanet57 80612004
UMLS via Orphanet61 C0023281
OMIM46 608207
MESH via Orphanet35 D007896

Related Diseases for Leishmaniasis

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17GeneCards, 18GeneDecks
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Diseases related to Leishmaniasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 266)
idRelated DiseaseScoreTop Affiliating Genes
1visceral leishmaniasis31.8PKD2L1
2cutaneous leishmaniasis31.8IL10, IFNG
3mucocutaneous leishmaniasis31.3PKD2L1
4chagas disease30.6MT-CYB
5malaria30.6HSPA4, IFNG, IFNGR1, TNF, MT-CYB, IL10
6leprosy30.5SLC11A1
7arthritis30.4IFNG, TNF, FOXP3, LTA, CXCR1, IL13
8uveitis30.3IFNG, TNF, LTA, CXCR1, IL10, IL4
9rheumatoid arthritis30.3CXCR1, LTA, FOXP3, TNF, IFNG, IL13
10tuberculosis30.2SLC11A1, HSPA4, IFNG, IFNGR1, IL4, IL10
11hepatitis30.1LTA
12tuberculoid leprosy30.1IFNG, IL10
13dermatitis30.1IFNG, FOXP3, IL13, IL5, IL4
14lepromatous leprosy30.1IL4, IL10, LTA, IFNG
15sarcoidosis29.9HSPA4, IFNG, IFNGR1, TNF, LTA, IL13
16leukemia29.9HSPA4, IFNG, TNF, FOXP3, LTA, CXCR1
17connective tissue disease29.9IL4, IL10, FOXP3, TNF
18lymphopenia29.9IFNG, FOXP3, IL10, IL4
19psoriatic arthritis29.9TNF
20chronic granulomatous disease29.9MT-CYB
21ankylosing spondylitis29.9TNF
22psoriasis29.7IFNG, TNF, LTA, CXCR1, IL13, IL10
23pulmonary tuberculosis29.7IFNG, IFNGR1, CXCR1, IL10, IL4, SLC11A1
24schistosomiasis29.7IFNG, IFNGR1, IL13, IL10, IL5, IL4
25systemic lupus erythematosus29.7IFNG, IFNGR1, TNF, LTA, IL10, IL4
26diabetes mellitus29.7HSPA4, TNF, FOXP3
27aspergillosis29.7MT-CYB, IFNG
28filariasis29.7IL5, IL13
29hepatitis b29.7IFNG, HSPA4
30myeloma29.7IL4, LTA
31acute leukemia29.7CSN2, CXCR1
32onchocerciasis29.7IL5
33pulmonary sarcoidosis29.7IFNG, TNF, LTA
34nephrotic syndrome29.7IL13
35tonsillitis29.7LTA
36pancreatitis29.7IL10
37sarcoma29.7HSPA4
38trypanosomiasis10.5
39immune-complex glomerulonephritis10.4
40hemophagocytic lymphohistiocytosis10.2
41acquired immunodeficiency syndrome10.2
42erysipeloid10.2
43indeterminate leprosy10.2
44strongyloidiasis10.2
45felty's syndrome10.2
46leptospirosis10.2
47disseminated intravascular coagulation10.2
48syphilis10.2
49toxoplasmosis10.2
50sleeping sickness10.2

Graphical network of the top 20 diseases related to Leishmaniasis:



Diseases related to leishmaniasis

Clinical Features for Leishmaniasis

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46OMIM
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Clinical features from OMIM:

608207

Drugs & Therapeutics for Leishmaniasis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Leishmaniasis

Drug clinical trials:

Search ClinicalTrials for Leishmaniasis

Search NIH Clinical Center for Leishmaniasis

Search CenterWatch for Leishmaniasis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Leishmaniasis

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Anatomical Context for Leishmaniasis

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32MalaCards
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MalaCards organs/tissues related to Leishmaniasis:

32
Skin, Liver, Spleen, Bone marrow, Bone, T cells, Testes, Monocytes, Kidney, Whole blood, B cells, Pancreas, Lymph node, Salivary gland, Brain, Spinal cord, Myeloid, Tonsil, Smooth muscle, Prostate, Colon, Endothelial

Animal Models for Leishmaniasis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Leishmaniasis:

36 (show all 14)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539711.5IFNG, IFNGR1, TNF, FOXP3, MPI, LTA
2MP:000538111.3IFNG, IFNGR1, TNF, FOXP3, IL13, IL10
3MP:000538711.3FOXP3, TNF, IFNGR1, IFNG, LTA, IL13
4MP:000538411.2HSPA4, IFNG, IFNGR1, TNF, FOXP3, MPI
5MP:000537011.2IFNG, IFNGR1, TNF, FOXP3, LTA, IL10
6MP:001076811.2HSPA4, IFNG, IFNGR1, TNF, FOXP3, MPI
7MP:000537911.1IL4, HSPA4, IFNG, TNF, FOXP3, LTA
8MP:000538910.9IFNGR1, PGD, IL13
9MP:001077110.8CSN2, FOXP3, IL13
10MP:000200610.8IFNG, IFNGR1, TNF, IL10, IL5, SLC11A1
11MP:000538610.8HSPA4, IFNG, IFNGR1, TNF, FOXP3, LTA
12MP:000538810.7LTA
13MP:000363110.7LTA, PKD2L1, MPI, HSPA4
14MP:000539110.7FOXP3, MPI

Publications for Leishmaniasis

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50PubMed
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Articles related to Leishmaniasis:

(show top 50)    (show all 1602)
idTitleAuthorsYear
1
Molecular diagnosis of leishmaniasis at the subgenus and species level. (24189975)
2013
2
The therapeutic potential of immune cross-talk in leishmaniasis. (23398405)
2013
3
Outbreak of cutaneous leishmaniasis in Fuenlabrada, Madrid. (23567452)
2013
4
Imported case of visceral leishmaniasis presenting as pancytopenia in a Norwegian patient treated with methotrexate and etanercept for psoriasis arthritis. (22886470)
2013
5
Visceral leishmaniasis involving the bone marrow. (24063037)
2013
6
Quinolines as chemotherapeutic agents for leishmaniasis. (23469781)
2013
7
Comparative study of microscopy and polymerase chain reaction for the diagnosis of suspected visceral leishmaniasis patients in Nepal. (23774406)
2013
8
Leishmaniasis acquired by travellers to endemic regions in Europe - A EuroTravNet multi-centre study. (24388687)
2013
9
Sun, sangria and sandflies: Leishmaniasis in an immunosuppressed patient returning from Spain. (23369438)
2013
10
First molecular identification of Leishmania species in a new endemic area of cutaneous leishmaniasis in Lorestan, Iran. (23827149)
2013
11
Development of assays using hexokinase and phosphoglucomutase gene sequences that distinguish strains of Leishmania tropica from different zymodemes and microsatellite clusters and their application to Palestinian foci of cutaneous leishmaniasis. (24086789)
2013
12
Pharmacokinetics and absorption of paromomycin and gentamicin from topical creams used to treat cutaneous leishmaniasis. (23877689)
2013
13
Anti-leishmania infantum IgG antibody avidity in visceral leishmaniasis. (24006136)
2013
14
The burden of visceral leishmaniasis in Italy from 1982 to 2012: a retrospective analysis of the multi-annual epidemic that occurred from 1989 to 2009. (23929120)
2013
15
Serotonin transporter protein overexpression and association to Th 17 and T regulatory cells in lupoid leishmaniasis. (23989888)
2013
16
Assessment of the quality of life of patients with cutaneous leishmaniasis in Belo Horizonte, Brazil, 2009-2010. A pilot study. (23474473)
2013
17
Insecticide susceptibility status of Phlebotomus argentipes, a vector of visceral leishmaniasis in different foci in three states of India. (23428526)
2012
18
Visceral leishmaniasis in a rheumatoid arthritis patient treated with methotrexate. (22198490)
2012
19
Evaluation of nephroprotective and immunomodulatory activities of antioxidants in combination with cisplatin against murine visceral leishmaniasis. (22563510)
2012
20
An early reduction in Treg cells correlates with enhanced local inflammation in cutaneous leishmaniasis in CCR6-deficient mice. (23028548)
2012
21
Phlebotomine sandflies (Diptera: Psychodidae) in SALo Vicente FAcrrer, a sympatric area to cutaneous and visceral leishmaniasis in the state of Pernambuco, Brazil. (22370831)
2012
22
Profile of anti-Leishmania antibodies related to clinical picture in canine visceral leishmaniasis. (22226072)
2012
23
Comparative assessment of a DNA and protein Leishmania donovani gamma glutamyl cysteine synthetase vaccine to cross-protect against murine cutaneous leishmaniasis caused by L. major or L. mexicana infection. (22210224)
2012
24
IL-27 and IL-21 are associated with T cell IL-10 responses in human visceral leishmaniasis. (21357266)
2011
25
Liquid nitrogen cryotherapy on Leishmania donovani cutaneous leishmaniasis. (20818996)
2011
26
Radiofrequency-induced heat therapy as first-line treatment for cutaneous leishmaniasis. (21692665)
2011
27
Phenology and population dynamics of sand flies in a new focus of visceral leishmaniasis in Eastern Azarbaijan Province, North western of Iran. (21914536)
2011
28
Allelic polymorphism of human FcI^RIIA-H/R131 receptor in American tegumentary leishmaniasis. (21324097)
2011
29
Evaluation of rk39 immunochromatographic test with urine for diagnosis of visceral leishmaniasis. (21708392)
2011
30
Study of sand fly fauna in an endemic area of American cutaneous leishmaniasis and canine visceral leishmaniasis in the municipality of EspA-rito Santo do Pinhal, SALo Paulo, Brazil. (20428683)
2010
31
Quantification of parasite load in clinical samples of leishmaniasis patients: IL-10 level correlates with parasite load in visceral leishmaniasis. (20404924)
2010
32
Comparative evaluation of phenol and thimerosal as preservatives for a candidate vaccine against American cutaneous leishmaniasis. (20209335)
2010
33
Fissure leishmaniasis: A new variant of cutaneous leishmaniasis. (19951631)
2009
34
Interventions for American cutaneous and mucocutaneous leishmaniasis. (19370612)
2009
35
Neglected diseases in the news: a content analysis of recent international media coverage focussing on leishmaniasis and trypanosomiasis. (18478048)
2008
36
Human placental extract offers protection against experimental visceral leishmaniasis: a pilot study for a phase-I clinical trial. (18186975)
2008
37
The epidemiology of visceral leishmaniasis and asymptomatic leishmanial infection in a highly endemic Bangladeshi village. (17488915)
2007
38
A rare presentation of visceral leishmaniasis without fever or splenomegaly in an elderly person. (17338973)
2007
39
Atypical clinical form of cutaneous leishmaniasis: erysipeloid form. (15533066)
2004
40
Antigen genes for molecular epidemiology of leishmaniasis: polymorphism of cysteine proteinase B and surface metalloprotease glycoprotein 63 in the Leishmania donovani complex. (14999607)
2004
41
Mucocutaneous leishmaniasis in a US citizen. (14600692)
2003
42
Interferon-gamma treatment induces granulomatous tissue reaction in a case of localized cutaneous leishmaniasis. (12142611)
2002
43
Detection of iNOS gene expression in cutaneous leishmaniasis biopsy tissue. (11985871)
2002
44
Herpes zoster and lymphopenia associated with sodium stibogluconate therapy for cutaneous leishmaniasis. (9770149)
1998
45
Human leishmaniasis: clinical, diagnostic, and chemotherapeutic developments in the last 10 years. (9145744)
1997
46
Splenomegaly in Baringo District, Kenya, an area endemic for visceral leishmaniasis and malaria. (7483000)
1995
47
Rural campaign to diagnose and treat mucocutaneous leishmaniasis in Bolivia. (7614666)
1995
48
Effect of treatment with interferon-gamma alone in visceral leishmaniasis. (7594733)
1995
49
Successful treatment of refractory visceral leishmaniasis in India using antimony plus interferon-gamma. (8077725)
1994
50
T-cell responses to infected autologous monocytes in patients with cutaneous and mucocutaneous leishmaniasis. (7496967)
1994

Genetic Variations for Leishmaniasis

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Expression for genes affiliated with Leishmaniasis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Leishmaniasis

Search GEO for disease gene expression data for Leishmaniasis.

Pathways for genes affiliated with Leishmaniasis

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Sources:
29KEGG, 51QIAGEN, 12EMD Millipore, 37NCBI BioSystems Database, 52R&D Systems, 53Reactome
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Pathways related to Leishmaniasis according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.1HSPA4, IFNG, IFNGR1, TNF, LTA, IL13
210.9IL4, IFNG, TNF, LTA, IL13, IL10
310.9IFNG, LTA, IL13, IL10, IL5, IL4
410.9IFNG, IFNGR1, IL13, IL10, IL5, IL4
5
Hide members
10.9TNF, LTA, IL13, IL10, IL5, IL4
6
Hide members
10.9IFNG, IFNGR1, TNF, LTA, IL13, IL4
7
Hide members
10.9IFNG, IFNGR1, TNF, IL13, IL5, IL4
8
Hide members
10.8IL4, IL5, IL10, TNF, IFNG
9
Hide members
10.8IFNG, IFNGR1, TNF, LTA, IL10
10
Hide members
10.8IL4, IL5, FOXP3, TNF, IFNG
1110.8IFNG, CSN2, IL13, IL5, IL4
12
Hide members
10.8IFNG, IFNGR1, CSN2, TNF, IL4
13
Hide members
10.8HSPA4, IFNG, IFNGR1, TNF, LTA
1410.7LTA, IL10, IL5, IL4
15
Hide members
10.7IL10, FOXP3, TNF, IFNG
1610.7IL10, TNF, IFNGR1, IFNG
17
Hide members
10.7IL10, TNF, IFNGR1, IFNG
18
Hide members
10.7LTA, TNF, IFNGR1, IFNG
19
Hide members
10.7IL5, IL13, FOXP3, IFNGR1
20
Hide members
10.7IFNGR1, CXCR1, IL13, IL5
2110.7IFNG, IL5, IL4
2210.7IL10, TNF, IFNG
2310.7IL4, IL5, IL13
2410.7IL4, IL5, TNF
25
Hide members
10.7IL5, IL13, LTA
26
Hide members
10.7LTA, IL13, IL5
27
Hide members
10.7FOXP3, LTA, IL4
28
Immune response Bacterial infections in normal airways
10.7IFNG, IFNGR1, TNF

Compounds for genes affiliated with Leishmaniasis

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 59Tocris Bioscience, 49PharmGKB, 28IUPHAR
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Compounds related to Leishmaniasis according to GeneCards/GeneDecks:

(show top 50)    (show all 124)
idCompoundScoreTop Affiliating Genes
1nitric oxide44 11 2413.5IL13, IL10, SLC11A1, PGD, LTA, MT-CYB
2vegf4411.4CXCR1, IL5, IL4, IL10, IL13, LTA
3il 104411.4TNF, IL13, IL10, IL5, IL4, IFNG
4tarc4411.4IL10, IL5, IFNG, TNF, CXCR1, IL13
5ionomycin4411.4IL4, IL5, IL13, IFNG, TNF, LTA
6herbimycin a44 5912.4IFNG, HSPA4, TNF, LTA, CXCR1, IL4
7il-124411.3IL5, TNF, IFNG, IL10, IL4, IL13
8sb 20358044 5912.3IL13, IFNG, HSPA4, TNF, IL10, IL5
9allergens4411.3IL5, IFNG, IL10, CSN2, IL13, IL4
10dexamethasone44 49 28 1114.3IL5, CXCR1, LTA, CSN2, HSPA4, IL13
11glatiramer acetate44 1112.3IL10, IL13, IL4, IFNG, IL5
12rantes4411.2LTA, IFNG, CXCR1, TNF, IL4
13aspartate4411.2PGD, MT-CYB, HSPA4, MDH2, MPI, SLC11A1
14okt34411.2IFNG, IL4, IL10, TNF, LTA
15thyroxine44 2412.2LTA, IL13, IL5, IL4, IL10, HSPA4
16budesonide44 49 1113.2TNF, IL13, IFNG, IL4, IL5
17actinomycin d4411.2CXCR1, HSPA4, IL4, IFNG, TNF, LTA
18fluticasone propionate44 49 59 1114.2IFNG, IL4, TNF, IL13, IL5
19polyinosinic-polycytidylic acid4411.2IFNG, IL5, IL10, IL4, TNF
20infliximab44 49 1113.2IL10, LTA, TNF, IFNG, IL4
21tacrolimus44 49 1113.2IFNG, TNF, IL13, IL10, IL5, IL4
22interferon gamma4411.2IL4, IL10, IFNG, TNF
23ccl344 2812.1IFNG, CXCR1, IL10, IL13, TNF
24alpha-galactosylceramide4411.1IFNG, IL4, IL10, IL13
25neopterin4411.1IL4, LTA, TNF, IL10, IFNG
26calcitriol44 59 11 2414.1IL4, IL10, TNF, IL13, LTA, IFNG
27h2o24411.1PGD, HSPA4, MDH2, MT-CYB, LTA, IL13
28gm-csf44 2812.1TNF, IL10, IFNG
29cycloheximide4411.1LTA, MT-CYB, LMLN
30mip 1alpha4411.1IL10, IL4, TNF, IL13
3115-deoxy-delta-12,14-prostaglandin j24411.1IFNG, TNF, IL4, HSPA4, IL10
32pentoxifylline44 1112.1IL13, IL4, LTA
33praziquantel44 1112.1IL5, IL4, IL10, IL13
34cyclosporin a44 28 5913.1LTA, IFNG, FOXP3
35prednisolone44 28 1113.1LTA, IL13, IL5
36lactate4411.0TNF, IL13, PGD, LTA, MDH2, CSN2
37thalidomide44 49 59 1114.0IL13, IL10, IFNG, TNF, IL5
38indomethacin44 59 28 1114.0IL5, HSPA4
39fmlp4411.0IL13, IL5, MT-CYB
40ivig4411.0IFNG
41imiquimod44 28 59 1113.9TNF, IFNG, IL10, IL5
42montelukast44 49 28 1113.9IL4, IL5, IL10, IL13
43polymyxin b4410.9IL4, TNF, IL10, IFNG
44amphotericin b4410.9IL13
45groalpha4410.8IL10, IL13, CXCR1, TNF
46indoleamine4410.8IL13
47con a4410.7IFNG, IL5, IL4, IL10
48betaseron4410.7IL4, IL10, IFNG
49omalizumab44 1111.6IL4, IL5, IL13
50superoxide44 2411.5MT-CYB, TNF, MDH2, MPI, PGD

GO Terms for genes affiliated with Leishmaniasis

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Sources:
16Gene Ontology
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Cellular components related to Leishmaniasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.7IL4, IL13, TNF, IFNG
2extracellular spaceGO:00561510.6IL4, IFNG, TNF, LTA, IL13, IL10

Biological processes related to Leishmaniasis according to GeneCards/GeneDecks:

(show all 30)
idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:00695411.2TNF, CXCR1, IL13, IL10, IL5, SLC11A1
2response to drugGO:04249311.2IFNG, TNF, LTA, IL10, IL4
3negative regulation of growth of symbiont in hostGO:04413011.1IL10, LTA, TNF, IFNG
4positive regulation of sequence-specific DNA binding transcription factor activityGO:05109111.1TNF, IL10, IL5, IL4
5positive regulation of transcription from RNA polymerase II promoterGO:04594411.1IFNG, TNF, FOXP3, IL10, IL4, SLC11A1
6positive regulation of MHC class II biosynthetic processGO:04534811.1IFNG, IL10, IL4
7response to virusGO:00961511.1IFNG, IFNGR1, TNF, FOXP3
8positive regulation of chemokine biosynthetic processGO:04508011.1IL4, TNF, IFNG
9defense response to protozoanGO:04283211.1SLC11A1, IL4, IFNG
10negative regulation of interleukin-6 productionGO:03271511.0IL10, FOXP3, TNF
11protein import into nucleus, translocationGO:00006011.0IFNG, TNF, SLC11A1
12positive regulation of interferon-gamma productionGO:03272911.0TNF, LTA, SLC11A1
13positive regulation of B cell proliferationGO:03089011.0IL13, IL5, IL4
14positive regulation of chronic inflammatory response to antigenic stimulusGO:00287611.0LTA, TNF
15positive regulation of vitamin D biosynthetic processGO:06055710.9TNF, IFNG
16humoral immune responseGO:00695910.9IFNG, TNF, LTA
17positive regulation of calcidiol 1-monooxygenase activityGO:06055910.9IFNG, TNF
18regulation of isotype switchingGO:04519110.9IL10, IL4
19receptor biosynthetic processGO:03280010.9TNF, IL10
20negative regulation of chronic inflammatory responseGO:00267710.9FOXP3, IL4
21type 2 immune responseGO:04209210.9IL4, IL10
22regulation of proton transportGO:01015510.8IL13, IL4
23negative regulation of cytokine secretion involved in immune responseGO:00274010.8TNF, IL10
24positive regulation of podosome assemblyGO:07180310.8TNF, IL5
25positive regulation of isotype switching to IgG isotypesGO:04830410.7IFNG, IL4
26positive regulation of transcription, DNA-dependentGO:04589310.7TNF, FOXP3, IL10, IL5, IL4
27positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.7TNF, LTA
28positive regulation of membrane protein ectodomain proteolysisGO:05104410.6TNF, IFNG
29positive regulation of immunoglobulin productionGO:00263910.6IL13, FOXP3
30negative regulation of nitric oxide biosynthetic processGO:04501910.3IL4, IL10

Molecular functions related to Leishmaniasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.9IL4, IL5, IL10, IL13, LTA, TNF

Products for genes affiliated with Leishmaniasis

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Sources for Leishmaniasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet