MCID: LSH001
MIFTS: 63

Leishmaniasis malady

Rare diseases, Infectious diseases categories

Aliases & Classifications for Leishmaniasis

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Sources:
42NIH Rare Diseases, 8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 32MedlinePlus, 2CDC, 61UMLS, 56SNOMED-CT, 33MeSH, 39NCIt, 27ICD9CM, 34MESH via Orphanet, 26ICD10 via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Aliases & Descriptions for Leishmaniasis:

Name: Leishmaniasis 8 42 10 44 48 32 2 61
Leishmaniasis, Cutaneous 61
Leishmaniasis, Visceral 61
 
Cutaneous Leishmaniasis 42
Visceral Leishmaniasis 42
Kala-Azar 42


Classifications:



Characteristics (Orphanet epidemiological data):

48
leishmaniasis:
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe),1-5/10000 (Worldwide),>1/1000 (Worldwide); Age of onset: All ages


External Ids:

Disease Ontology8 DOID:9065
MeSH33 D007896
NCIt39 C34767
ICD9CM27 085, 085.9
Orphanet48 507
MESH via Orphanet34 D007896
ICD10 via Orphanet26 B55.0, B55.1, B55.2 B55.9, more
UMLS via Orphanet62 C0023281
ICD1025 B55

Summaries for Leishmaniasis

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MedlinePlus:32 Leishmaniasis is a parasitic disease spread by the bite of infected sand flies. there are several different forms of leishmaniasis. the most common are cutaneous and visceral. the cutaneous type causes skin sores. the visceral type affects internal organs such as the spleen, liver, and bone marrow. people with this form usually have fever, weight loss, and an enlarged spleen and liver. leishmaniasis is found in parts of about 88 countries. most of these countries are in the tropics and subtropics. it is possible but very unlikely that you would get this disease in the united states. but you should be aware of it if you are traveling to the middle east or parts of central america, south america, asia, africa or southern europe. treatment is with medicines that contain antimony, a type of metal, or with strong antibiotics. the best way to prevent the disease is to protect yourself from sand fly bites: stay indoors from dusk to dawn, when sand flies are the most active wear long pants and long-sleeved shirts when outside use insect repellent and bed nets as needed centers for disease control and prevention

MalaCards based summary: Leishmaniasis, also known as leishmaniasis, cutaneous, is related to cutaneous leishmaniasis and mucocutaneous leishmaniasis. An important gene associated with Leishmaniasis is IFNG (interferon, gamma), and among its related pathways are Inflammatory Response Pathway and Immune response IL 23 signaling pathway. The drugs itraconazole and meglumine and the compounds alpha-galactosylceramide and interferon gamma have been mentioned in the context of this disorder. Affiliated tissues include skin, bone marrow and bone, and related mouse phenotypes are craniofacial and tumorigenesis.

Disease Ontology:8 A parasitic protozoa infectious disease that involves infection caused by protozoan parasite of the genus leishmania, which is transmitted by the bite of sand fly (subfamily phlebotominae).

NIH Rare Diseases:42 Leishmaniasis is a parasitic disease spread by the bite of infected sand flies. there are several different forms of leishmaniasis. the most common are cutaneous and visceral. the cutaneous type causes skin sores. the visceral type affects internal organs such as the spleen, liver and bone marrow. people with this form usually have fever, weight loss, and an enlarged spleen and liver. visceral disease can be deadly without proper treatment. leishmaniasis is found in parts of the middle east, central america, south american, asia, africa, and southern europe. most of these countries are in the tropics and subtropics. it is possible but very unlikely to get this disease in the united states. last updated: 7/6/2011

CDC:2 Leishmaniasis is a parasitic disease that is found in parts of the tropics, subtropics, and southern Europe. It is classified as a Neglected Tropical Disease (NTD). Leishmaniasis is caused by infection with Leishmania parasites, which are spread by the bite of phlebotomine sand flies. There are several different forms of leishmaniasis in people. The most common forms are cutaneous leishmaniasis, which causes skin sores, and visceral leishmaniasis, which affects several internal organs (usually spleen, liver, and bone marrow).

Wikipedia:64 Leishmaniasis (/?li??m??na??s?s/) or leishmaniosis (/li???me?n??o?s?s/ or /li???m more...

Related Diseases for Leishmaniasis

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Diseases related to Leishmaniasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 230)
idRelated DiseaseScoreTop Affiliating Genes
1cutaneous leishmaniasis32.6IFNG, IL10
2mucocutaneous leishmaniasis32.3PKD2L1
3visceral leishmaniasis31.9LMLN, PGD, IFNG, IL4, IL10, SLC11A1
4leprosy31.5SLC11A1
5malaria31.2TNF, IFNG, IL10
6strongyloidiasis31.1IL5
7tuberculoid leprosy30.9IFNG, IL10
8schistosomiasis30.6IL5, IL13
9lepromatous leprosy30.6LTA, IL10, IL4, IFNG
10filariasis30.4IL13, IL5
11psoriatic arthritis30.4IL13, TNF
12aspergillosis30.3MT-CYB, IFNG
13dermatitis30.3FOXP3, IL4, IL13
14uveitis30.2TNF, CXCR1, IFNG, IL4, IL10, LTA
15pulmonary sarcoidosis30.2TNF, IFNG, LTA
16lymphopenia30.1FOXP3, IFNG, IL4, IL10
17hodgkin lymphoma30.1HSPA4, IL13, LTA
18chronic granulomatous disease30.0MT-CYB, IFNG
19connective tissue disease29.9TNF, FOXP3, IL4, IL10
20systemic lupus erythematosus29.5TNF, IFNGR1, IFNG, IL4, IL10, LTA
21pulmonary tuberculosis29.5CXCR1, IFNGR1, IFNG, IL4, IL10, SLC11A1
22arthritis29.4TNF, CXCR1, FOXP3, IFNG, IL4, IL10
23tuberculosis29.4TNF, HSPA4, CXCR1, IFNGR1, IFNG, IL4
24rheumatoid arthritis29.3TNF, CXCR1, FOXP3, IFNG, IL4, IL10
25psoriasis29.2TNF, CXCR1, IFNG, IL4, IL5, IL10
26leukemia29.1TNF, HSPA4, CXCR1, FOXP3, IFNG, IL4
27trypanosomiasis10.6
28periapical granuloma10.6IL4
29eosinophilic fasciitis10.5IL5
30chagas disease10.5
31intraocular lymphoma10.5IL10
32meniere's disease10.5HSPA4
33vulvovaginitis10.5HSPA4
34kimura disease10.5IL5
35eosinophilia-myalgia syndrome10.5IL5
36esophagitis, eosinophilic, 110.5IL5
37hyper-ige recurrent infection syndrome10.4IL4, IFNG
38immune-complex glomerulonephritis10.4
39omenn syndrome10.4IL4, IL5
40blau syndrome10.4TNF
41keratoconjunctivitis10.4IL5, IL13
42mycobacterium avium complex disease10.4IFNGR1
43egg allergy10.4IL4, IL5
44relapsing-remitting multiple sclerosis10.4IL10, IFNG
45intrinsic asthma10.4IL5, IL4
46allergic bronchopulmonary aspergillosis10.4IL5, IL4
47agammaglobulinemia10.4LTA, IL4
48diabetes mellitus, insulin-dependent10.4IFNG, IL4, IL10
49parasitic helminthiasis infectious disease10.4IL13, IL5
50alcoholic hepatitis10.4IL10, TNF

Graphical network of the top 20 diseases related to Leishmaniasis:



Diseases related to leishmaniasis

Symptoms for Leishmaniasis

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Drugs & Therapeutics for Leishmaniasis

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Drug clinical trials:

Search ClinicalTrials for Leishmaniasis

Search NIH Clinical Center for Leishmaniasis

Inferred drug relations via UMLS61/NDF-RT40:

Genetic Tests for Leishmaniasis

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Anatomical Context for Leishmaniasis

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MalaCards organs/tissues related to Leishmaniasis:

31
Skin, Bone marrow, Bone, Liver, Spleen, T cells, Testes, Monocytes, Kidney, Whole blood, Lymph node, Brain, Pancreas, B cells, Neutrophil, Spinal cord, Smooth muscle, Colon, Salivary gland, Prostate, Tonsil, Myeloid, Nk cells, Endothelial

Animal Models for Leishmaniasis or affiliated genes

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MGI Mouse Phenotypes related to Leishmaniasis:

35 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053829.1IL10, IFNG, FOXP3, TNF, IL4
2MP:00020069.1TNF, IFNG, IL10, SLC11A1, IL5, IFNGR1
3MP:00030128.9IL13, IL10, IFNG, FOXP3, TNF, IL4
4MP:00053908.8IFNGR1, IFNG, IL4, IL10, LTA, TNF
5MP:00053918.8IFNG, TNF, MPI, FOXP3, LTA, IL4
6MP:00107718.7TNF, IFNGR1, IFNG, IL4, IL10, IL13
7MP:00053888.6IFNG, LTA, IL13, IL10, IL5, IL4
8MP:00053708.5IL5, IL10, LTA, TNF, IFNG, IFNGR1
9MP:00053808.5IL5, IFNGR1, IL10, TNF, MPI, IFNG
10MP:00053858.4FOXP3, MPI, TNF, IFNG, IL10, LTA
11MP:00053818.3IL10, IL13, IL5, IL4, IFNG, IFNGR1
12MP:00053788.2IL5, TNF, FOXP3, IL4, IL10, IL13
13MP:00053768.1IL10, TNF, FOXP3, IFNGR1, IFNG, IL4
14MP:00053798.0HSPA4, FOXP3, IFNGR1, IFNG, IL4, IL13
15MP:00053878.0TNF, IFNGR1, IFNG, FOXP3, LTA, IL13
16MP:00053867.9IFNGR1, TNF, IFNG, IL10, PGD, IL5
17MP:00053847.9FOXP3, IL13, MPI, HSPA4, TNF, IFNG
18MP:00053897.8IL13, TNF, IL10, IL5, IL4, IFNG
19MP:00053977.7LTA, SLC11A1, IL13, IL10, IL5, IL4
20MP:00036317.7IFNG, IFNGR1, TNF, HSPA4, MPI, LTA
21MP:00107687.4IL4, IL13, FOXP3, IL10, LTA, SLC11A1

Publications for Leishmaniasis

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Articles related to Leishmaniasis:

(show top 50)    (show all 1701)
idTitleAuthorsYear
1
Epidemiological aspects of vector, parasite, and domestic reservoir in areas of recent transmission and no reported human cases of visceral leishmaniasis in Brazil. (25882769)
2015
2
Evaluation of the immunoprophylactic potential of a killed vaccine candidate in combination with different adjuvants against murine visceral leishmaniasis. (25316605)
2014
3
Zosteriform cutaneous leishmaniasis. (25396096)
2014
4
Cutaneous leishmaniasis responds to daylight-activated photodynamic therapy: Proof-of-concept for a novel self-administered therapeutic modality. (25363817)
2014
5
Cutaneous Leishmaniasis Mimicking A Pyogenic Granuloma. (24923493)
2014
6
Visceral leishmaniasis in Brazil: rationale and concerns related to reservoir control. (25372177)
2014
7
Treatment-based strategy for the management of post-kala-azar dermal leishmaniasis patients in the Sudan. (23690794)
2013
8
Experimental infection of dogs with Leishmania and saliva as a model to study Canine Visceral Leishmaniasis. (23577121)
2013
9
Molecular diagnosis of leishmaniasis at the subgenus and species level. (24189975)
2013
10
Atypical presentation of cutaneous leishmaniasis in a renal transplant recipient successfully treated with allopurinol and fluconazole. (22750767)
2013
11
Pentalinon andrieuxii Root Extract is Effective in the Topical Treatment of Cutaneous Leishmaniasis Caused by Leishmania mexicana. (24347110)
2013
12
Clinical findings and management of imported cutaneous leishmaniasis: report of 14 cases from Austria. (23522841)
2013
13
Ecology of leishmaniasis in the South of France. 22. Reliability and representativeness of 12 Phlebotomus ariasi, P. perniciosus and Sergentomyia minuta (Diptera: Psychodidae) sampling stations in Vallespir (eastern French Pyrenees region). (24112589)
2013
14
What is responsible for a large and unusual outbreak of leishmaniasis in Madrid? (24275160)
2013
15
Role of fine-needle aspiration cytology in the prompt diagnosis of recurrence of visceral leishmaniasis presented as isolated cervical leishmanial lymphadenopathy. (21671412)
2013
16
Effect of 3-alkylpyridine marine alkaloid analogues in Leishmania species related to American cutaneous leishmaniasis. (22882996)
2012
17
Factors associated with asymptomatic infection in family members and neighbors of patients with visceral leishmaniasis. (23288063)
2012
18
Killed but metabolically active Leishmania infantum as a novel whole-cell vaccine for visceral leishmaniasis. (22323556)
2012
19
Prevalence, features and risk factors for malaria co-infections amongst visceral leishmaniasis patients from Amudat Hospital, Uganda. (22506087)
2012
20
Comparative study of rK39 Leishmania antigen for serodiagnosis of visceral leishmaniasis: systematic review with meta-analysis. (22303488)
2012
21
Recent advances in development of amphotericin B formulations for the treatment of visceral leishmaniasis. (23147810)
2012
22
Resistance to visceral leishmaniasis is severely compromised in mice deficient of bradykinin B2-receptors. (23151408)
2012
23
Distinct pattern of immunophenotypic features of innate and adaptive immunity as a putative signature of clinical and laboratorial status of patients with localized cutaneous leishmaniasis. (22823491)
2012
24
The knowledge, attitude, and prevention practices of students regarding cutaneous leishmaniasis in the hyperendemic region of the Shahid Babaie Airbase. (22022818)
2012
25
Latency time in cutaneous leishmaniasis. (21505401)
2011
26
IL-27 and IL-21 are associated with T cell IL-10 responses in human visceral leishmaniasis. (21357266)
2011
27
PKCI' regulates IL-12p40/p70 production by macrophages and dendritic cells, driving a type 1 healer phenotype in cutaneous leishmaniasis. (21287553)
2011
28
First report on natural infection of Phlebotomus sergenti with Leishmania promastigotes in the cutaneous leishmaniasis focus in southeastern Tunisia. (21976566)
2011
29
Canine visceral leishmaniasis: study of methods for the detection of IgG in serum and eluate samples. (21748226)
2010
30
Sand fly Surveillance within an Emerging Epidemic Focus of Cutaneous Leishmaniasis in Southeastern Iran. (22808384)
2010
31
Treatment of acute cutaneous leishmaniasis with intralesional injection of meglumine antimoniate: comparison of conventional technique with mesotherapy gun. (20883265)
2010
32
CD8+ T cells as a source of IFN-I^ production in human cutaneous leishmaniasis. (20967288)
2010
33
Comparison of three methods for diagnosis of cutaneous leishmaniasis. (22347259)
2010
34
Immunophenotypic pattern and cytokine profiles of dry type cutaneous leishmaniasis. (19566354)
2009
35
IFN-beta impairs superoxide-dependent parasite killing in human macrophages: evidence for a deleterious role of SOD1 in cutaneous leishmaniasis. (19201909)
2009
36
Anti-iL-10 mAb protection against experimental visceral leishmaniasis via induction of Th1 cytokines and nitric oxide. (19634715)
2009
37
Relapsing cutaneous leishmaniasis in a patient with ankylosing spondylitis treated with infliximab. (19556566)
2009
38
Pregnancy enhances the innate immune response in experimental cutaneous leishmaniasis through hormone-modulated nitric oxide production. (18347075)
2008
39
Treatment of mucosal leishmaniasis in Latin America: systematic review. (17690398)
2007
40
Report of an atypical case of leishmaniasis presented as acute tonsillitis in an immunocompetent patient. (16308231)
2005
41
Adenosine deaminase activity in sera of patients with visceral leishmaniasis in Nepal. (15970028)
2005
42
Mucocutaneous leishmaniasis: an imported infection among travellers to central and South America. (15472268)
2004
43
Recent advances in research and control of malaria, leishmaniasis, trypanosomiasis and schistosomiasis. (15748049)
2003
44
Rhabdomyolysis induced by pentamidine (Pentacarinat) during treatment of cutaneous leishmaniasis: 2 cases]. (11937930)
2002
45
Chronic dacryocystitis in American mucocutaneous leishmaniasis. (11206745)
2001
46
In situ expression of interleukin-10 and interleukin-12 in active human cutaneous leishmaniasis. (8880134)
1996
47
Polymorphism in tumor necrosis factor genes associated with mucocutaneous leishmaniasis. (7595196)
1995
48
CD23 and IgE expression during the human immune response to cutaneous leishmaniasis: possible role in monocyte activation. (8008965)
1994
49
Treatment of visceral leishmaniasis with pentavalent antimony and interferon gamma. (2104665)
1990
50
Mucocutaneous leishmaniasis--an unsolved clinical problem. (841692)
1977

Variations for Leishmaniasis

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Expression for genes affiliated with Leishmaniasis

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Search GEO for disease gene expression data for Leishmaniasis.

Pathways for genes affiliated with Leishmaniasis

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Pathways related to Leishmaniasis according to GeneCards Suite gene sharing:

(show all 41)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8IFNG, IL5, IL4
2
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway59
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB59
Development Angiopoietin Tie2 signaling59
9.8IL10, TNF, IFNG
39.8IFNG, TNF, IL10
49.8TNF, IFNG, IL10
59.8IFNG, TNF, IL10
69.8IL4, IFNG, TNF
79.7IL4, IL13, IL5
89.7IL13, IL10, TNF
9
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes59
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway59
9.7TNF, IL4, LTA
109.7IL5, IL4, TNF
119.6IL10, IL4, FOXP3
12
Show member pathways
Immune response MIF in innate immunity response59
9.6IFNG, TNF, IFNGR1
139.6IFNG, IFNGR1, TNF
149.6IFNGR1, TNF, IFNG
15
Show member pathways
IL2 signaling events mediated by STAT536
9.6LTA, FOXP3, IL4
169.5IFNG, IL4, IL13, IL5
179.5IL4, IL5, IL10, LTA
18
Show member pathways
Immune response BCR pathway59
Fc-epsilon receptor I signaling in mast cells36
9.4TNF, IL4, IL13, IL5
19
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
9.4TNF, IL10, IFNG, IFNGR1
209.4IL10, IFNG, IFNGR1, TNF
21
Show member pathways
9.4IFNG, IFNGR1, TNF, IL4
22
Show member pathways
Immune response CD16 signaling in NK cells59
9.4IL4, IFNGR1, TNF, IFNG
23
Show member pathways
9.4IL10, IFNG, FOXP3, TNF
24
Show member pathways
9.3IFNGR1, TNF, IFNG, LTA
25
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
9.3IL5, IL10, TNF, IL4, IFNG
26
Show member pathways
IL27-mediated signaling events36
9.1IFNG, IL10, IFNGR1, LTA, TNF
27
Show member pathways
Transcription NF kB signaling pathway59
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response59
9.1LTA, IL4, IFNG, IFNGR1, TNF
28
Show member pathways
Calcium signaling in the CD4+ TCR pathway36
9.1IL5, TNF, IL4, IFNG, FOXP3
299.0LTA, IL13, IL10, IL5, IL4, IFNG
309.0IL13, IL10, IL4, IFNG, TNF, IL5
31
Show member pathways
8.9TNF, IL4, IL5, IL10, LTA, IL13
32
Show member pathways
8.9TNF, IL4, IL5, IL10, LTA, IL13
33
Show member pathways
8.9LTA, IL13, TNF, IL4, IL5, IL10
34
Show member pathways
Type III interferon signaling36
8.9IL5, IL10, IFNG, IFNGR1, IL4, IL13
35
Show member pathways
8.9IFNGR1, IFNG, IL4, IL13, LTA, TNF
36
Show member pathways
8.8TNF, LTA, HSPA4, IFNGR1, IFNG
378.7TNF, LTA, IL13, IL10, IL5, IL4
38
Show member pathways
8.4IL4, IL5, IFNGR1, TNF, IL10, IL13
39
Show member pathways
8.2IFNG, TNF, IFNGR1, FOXP3, IL5, IL13
40
Show member pathways
7.9IL10, IL5, IL4, IFNG, TNF, CXCR1
41
Show member pathways
7.8IL13, LTA, IL10, IL5, HSPA4, IL4

Compounds for genes affiliated with Leishmaniasis

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Compounds related to Leishmaniasis according to GeneCards Suite gene sharing:

(show top 50)    (show all 150)
idCompoundScoreTop Affiliating Genes
1alpha-galactosylceramide4410.0IL4, IFNG, IL10, IL13
2interferon gamma449.9IFNG, TNF, IL4, IL10
3mip 1alpha449.8IL4, IL13, TNF, IL10
4praziquantel44 1110.8IL4, IL5, IL10, IL13
5glatiramer acetate44 1110.7IL13, IL10, IL5, IL4, IFNG
6amphotericin b449.7IL13, IFNG, IL4, IL5
7okt3449.7LTA, IL10, IL4, IFNG, TNF
8indoleamine449.7IFNG, TNF, IL10, IL13
9polyinosinic-polycytidylic acid449.6IL4, IL5, IL10, IFNG, TNF
10infliximab44 50 1111.6IL10, IL4, LTA, IFNG, TNF
11montelukast44 50 28 1112.6IL10, IL13, IL5, IL4
12budesonide44 50 1111.6TNF, IL13, IL5, IL4, IFNG
13fluticasone propionate44 50 60 1112.6IFNG, IL13, IL5, IL4, TNF
14neopterin449.6TNF, IFNG, LTA, IL10, IL4
15allergens449.6IFNG, IL10, IL4, IL5, IL13
16con a449.6IFNG, IL4, IL5, IL10
17imiquimod44 60 28 1112.5TNF, IFNG, IL10, IL5
18il-12449.5IL5, IL4, IL13, TNF, IL10, IFNG
19gm-csf44 2810.4IL5, IFNG, TNF, IL4, IL10, IL13
20pentoxifylline44 1110.4TNF, IL13, IFNG, IL10, IL4, LTA
21polymyxin b449.4TNF, IFNG, IL10, IL4
22rolipram44 60 2811.4IL13, TNF, IFNG, IL4, IL5, IL10
23thalidomide44 50 60 1112.4IL13, IL5, IFNG, TNF, IL10
24ivig449.4LTA, IL10, IL5, IFNG, TNF, IL4
25ccl344 2810.4CXCR1, IFNG, IL10, IL13, TNF
26hydrocortisone44 1 60 1112.4IL13, IL10, IL5, IL4, TNF, IFNG
27prednisolone44 28 1111.3IL10, IFNG, IL5, LTA, TNF, IL13
28rantes449.3IFNG, CXCR1, IL5, IL10, IL13, IL4
2915-deoxy-delta-12,14-prostaglandin j2449.3IFNG, TNF, HSPA4, IL4, IL10
30tacrolimus44 50 1111.3IL13, TNF, IFNG, IL4, IL5, IL10
31calcitriol44 60 24 1112.3IL10, IL4, TNF, IFNG, LTA, IL13
32il 10449.2IL5, IL10, IL13, LTA, TNF, IFNG
33ionomycin449.2IL10, IL13, LTA, IFNG, IL5, IL4
34endotoxin449.1CXCR1, TNF, IFNG, LTA, IL10, IL13
35thyroxine44 2410.1LTA, IL13, IL10, IL4, HSPA4, IL5
36tarc449.0IL4, IL5, IL10, IL13, TNF, IFNG
37groalpha449.0TNF, CXCR1, IL10, IL13
38fmlp448.9CXCR1, MT-CYB, IL5, IL13, LTA, TNF
39sb 20358044 609.9HSPA4, TNF, IL13, IFNG, IL4, IL5
40indomethacin44 28 60 1111.8HSPA4, IFNG, LTA, IL13, TNF, IL4
41thymidine44 249.8IL13, IFNG, IL10, IL5, TNF, IL4
42cyclosporin a44 28 6010.7TNF, LTA, IL13, IL10, IL5, IFNG
43pge2448.7FOXP3, IFNG, IL5, IL10, IL13, LTA
44herbimycin a44 609.6IL5, IFNG, CXCR1, HSPA4, TNF, LTA
45actinomycin d448.6IL4, CXCR1, HSPA4, TNF, LTA, IL13
46aspartate448.4HSPA4, MT-CYB, PGD, IL10, IL13, SLC11A1
47dexamethasone44 50 28 1111.2IL10, IL4, IFNG, CXCR1, HSPA4, TNF
48vegf448.1LTA, IL10, CXCR1, HSPA4, TNF, IL4
49nitric oxide44 24 119.9LTA, SLC11A1, IL13, TNF, HSPA4, PGD
50cycloheximide447.3LTA, TNF, HSPA4, LMLN, CXCR1, IL5

GO Terms for genes affiliated with Leishmaniasis

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Cellular components related to Leishmaniasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.5IL13, IL4, IFNG, TNF
2extracellular spaceGO:00056158.4LTA, TNF, IFNG, IL4, IL5, IL10

Biological processes related to Leishmaniasis according to GeneCards Suite gene sharing:

(show all 37)
idNameGO IDScoreTop Affiliating Genes
1regulation of isotype switchingGO:004519110.4IL10, IL4
2type 2 immune responseGO:004209210.4IL10, IL4
3positive regulation of vitamin D biosynthetic processGO:006055710.4TNF, IFNG
4positive regulation of calcidiol 1-monooxygenase activityGO:006055910.3IFNG, TNF
5positive regulation of isotype switching to IgG isotypesGO:004830410.3IL4, IFNG
6receptor biosynthetic processGO:003280010.3IL10, TNF
7regulation of proton transportGO:001015510.3IL4, IL13
8positive regulation of chronic inflammatory response to antigenic stimulusGO:000287610.3TNF, LTA
9positive regulation of MHC class II biosynthetic processGO:004534810.3IL10, IL4, IFNG
10negative regulation of nitric oxide biosynthetic processGO:004501910.2IL4, IL10
11negative regulation of cytokine secretion involved in immune responseGO:000274010.2IL10, TNF
12defense response to protozoanGO:004283210.2IFNG, IL4, SLC11A1
13positive regulation of podosome assemblyGO:007180310.2IL5, TNF
14negative regulation of chronic inflammatory responseGO:000267710.2FOXP3, IL4
15positive regulation of chemokine biosynthetic processGO:004508010.2TNF, IFNG, IL4
16positive regulation of humoral immune response mediated by circulating immunoglobulinGO:000292510.1LTA, TNF
17protein import into nucleus, translocationGO:000006010.1TNF, IFNG, SLC11A1
18positive regulation of membrane protein ectodomain proteolysisGO:005104410.1TNF, IFNG
19positive regulation of B cell proliferationGO:003089010.1IL5, IL13, IL4
20positive regulation of immunoglobulin productionGO:000263910.0FOXP3, IL13
21positive regulation of interferon-gamma productionGO:003272910.0TNF, LTA, SLC11A1
22defense response to bacteriumGO:004274210.0SLC11A1, IL10, IFNG
23humoral immune responseGO:000695910.0LTA, IFNG, TNF
24regulation of interferon-gamma-mediated signaling pathwayGO:006033410.0IFNG, IFNGR1
25negative regulation of interleukin-6 productionGO:003271510.0TNF, IL10, FOXP3
26positive regulation of cytokine productionGO:00018199.9TNF, SLC11A1
27negative regulation of growth of symbiont in hostGO:00441309.9LTA, IL10, IFNG, TNF
28positive regulation of osteoclast differentiationGO:00456729.9TNF, IFNG
29positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.9IL10, IL5, IL4, TNF
30negative regulation of interferon-gamma productionGO:00326899.9FOXP3, IL10
31response to lipopolysaccharideGO:00324969.8LTA, IL13, SLC11A1
32response to drugGO:00424939.7LTA, IL10, IL4, IFNG, TNF
33positive regulation of cytokine secretionGO:00507159.7IL10, TNF
34response to virusGO:00096159.6FOXP3, TNF, IFNGR1, IFNG
35positive regulation of transcription, DNA-templatedGO:00458939.4IL5, FOXP3, TNF, IL10, IL4
36positive regulation of transcription from RNA polymerase II promoterGO:00459449.3SLC11A1, TNF, IFNG, IL4, IL10, FOXP3
37inflammatory responseGO:00069549.2SLC11A1, IL13, IL5, CXCR1, TNF, IL10

Molecular functions related to Leishmaniasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:00051649.9LTA, TNF
2growth factor activityGO:00080839.5IL10, IL5, IL4
3cytokine activityGO:00051258.6LTA, TNF, IFNG, IL4, IL5, IL10

Sources for Leishmaniasis

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet