MCID: LSH001
MIFTS: 74

Leishmaniasis malady

Infectious diseases category

Summaries for Leishmaniasis

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 33MedlinePlus, 3CDC, 63Wikipedia, 46OMIM, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:33 Leishmaniasis is a parasitic disease spread by the bite of infected sand flies. there are several different forms of leishmaniasis. the most common are cutaneous and visceral. the cutaneous type causes skin sores. the visceral type affects internal organs such as the spleen, liver, and bone marrow. people with this form usually have fever, weight loss, and an enlarged spleen and liver. leishmaniasis is found in parts of about 88 countries. most of these countries are in the tropics and subtropics. it is possible but very unlikely that you would get this disease in the united states. but you should be aware of it if you are traveling to the middle east or parts of central america, south america, asia, africa or southern europe. treatment is with medicines that contain antimony, a type of metal, or with strong antibiotics. the best way to prevent the disease is to protect yourself from sand fly bites: stay indoors from dusk to dawn, when sand flies are the most active wear long pants and long-sleeved shirts when outside use insect repellent and bed nets as needed centers for disease control and prevention

MalaCards: Leishmaniasis, also known as leishmaniasis, unspecified, is related to visceral leishmaniasis and cutaneous leishmaniasis. An important gene associated with Leishmaniasis is IFNG (interferon, gamma), and among its related pathways are Allograft rejection and Cytokine Network. The drugs ketoconazole and itraconazole and the compounds nitric oxide and vegf have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and spleen, and related mouse phenotypes are hematopoietic system and digestive/alimentary.

Disease Ontology:8 A parasitic protozoa infectious disease that involves infection caused by protozoan parasite of the genus leishmania, which is transmitted by the bite of sand fly (subfamily phlebotominae).

NIH Rare Diseases:42 Leishmaniasis is a parasitic disease spread by the bite of infected sand flies. there are several different forms of leishmaniasis. the most common are cutaneous and visceral. the cutaneous type causes skin sores. the visceral type affects internal organs such as the spleen, liver and bone marrow. people with this form usually have fever, weight loss, and an enlarged spleen and liver. visceral disease can be deadly without proper treatment. leishmaniasis is found in parts of the middle east, central america, south american, asia, africa, and southern europe. most of these countries are in the tropics and subtropics. it is possible but very unlikely to get this disease in the united states. last updated: 7/6/2011

CDC:3 Leishmaniasis is a parasitic disease that is found in parts of the tropics, subtropics, and southern Europe. It is classified as a Neglected Tropical Disease (NTD). Leishmaniasis is caused by infection with Leishmania parasites, which are spread by the bite of phlebotomine sand flies. There are several different forms of leishmaniasis in people. The most common forms are cutaneous leishmaniasis, which causes skin sores, and visceral leishmaniasis, which affects several internal organs (usually spleen, liver, and bone marrow).

Wikipedia:63 Leishmaniasis /ˌliːʃməˈnaɪəsɪs/ or leishmaniosis (/liːʃˌmeɪnɪˈoʊsɪs/ or... more...

Description from OMIM:46 608207

Aliases & Classifications for Leishmaniasis

About this section
Sources:
42NIH Rare Diseases, 8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 46OMIM, 33MedlinePlus, 60UMLS, 27ICD9CM, 34MeSH, 39NCIt, 56SNOMED-CT, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 35MESH via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Characteristics (Orphanet epidemiological data):

48
leishmaniasis:
Inheritance: Sporadic; Prevalence: 1-9/1000000; Age of onset: Variable


Aliases & Descriptions:

leishmaniasis 8 42 10 44 48 46 33 60
leishmaniasis, unspecified 8
leishmaniasis, cutaneous 60
leishmaniasis, visceral 60
cutaneous leishmaniasis 42
visceral leishmaniasis 42
leishmaniasis nos 8
kala-azar 42


External Ids:

Disease Ontology8 DOID:9065
ICD9CM27 085, 085.9
MeSH34 D007896
NCIt39 C34767
ICD10 via Orphanet26 B55.0, B55.1, B55.2 B55.9, more
SNOMED-CT via Orphanet57 80612004
UMLS via Orphanet61 C0023281
OMIM46 608207
MESH via Orphanet35 D007896

Related Diseases for Leishmaniasis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Leishmaniasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 266)
idRelated DiseaseScoreTop Affiliating Genes
1visceral leishmaniasis31.8PKD2L1
2cutaneous leishmaniasis31.8IL10, IFNG
3mucocutaneous leishmaniasis31.3PKD2L1
4chagas disease30.6MT-CYB
5malaria30.6HSPA4, IFNG, IFNGR1, TNF, MT-CYB, IL10
6leprosy30.5SLC11A1
7arthritis30.4IFNG, TNF, FOXP3, LTA, CXCR1, IL13
8uveitis30.3IFNG, TNF, LTA, CXCR1, IL10, IL4
9rheumatoid arthritis30.3CXCR1, LTA, FOXP3, TNF, IFNG, IL13
10tuberculosis30.2SLC11A1, HSPA4, IFNG, IFNGR1, IL4, IL10
11hepatitis30.1LTA
12tuberculoid leprosy30.1IFNG, IL10
13dermatitis30.1IFNG, FOXP3, IL13, IL5, IL4
14lepromatous leprosy30.1IL4, IL10, LTA, IFNG
15sarcoidosis29.9HSPA4, IFNG, IFNGR1, TNF, LTA, IL13
16leukemia29.9HSPA4, IFNG, TNF, FOXP3, LTA, CXCR1
17connective tissue disease29.9IL4, IL10, FOXP3, TNF
18lymphopenia29.9IFNG, FOXP3, IL10, IL4
19psoriatic arthritis29.9TNF
20chronic granulomatous disease29.9MT-CYB
21ankylosing spondylitis29.9TNF
22psoriasis29.7IFNG, TNF, LTA, CXCR1, IL13, IL10
23pulmonary tuberculosis29.7IFNG, IFNGR1, CXCR1, IL10, IL4, SLC11A1
24schistosomiasis29.7IFNG, IFNGR1, IL13, IL10, IL5, IL4
25systemic lupus erythematosus29.7IFNG, IFNGR1, TNF, LTA, IL10, IL4
26diabetes mellitus29.7HSPA4, TNF, FOXP3
27aspergillosis29.7MT-CYB, IFNG
28filariasis29.7IL5, IL13
29hepatitis b29.7IFNG, HSPA4
30myeloma29.7IL4, LTA
31acute leukemia29.7CSN2, CXCR1
32onchocerciasis29.7IL5
33pulmonary sarcoidosis29.7IFNG, TNF, LTA
34nephrotic syndrome29.7IL13
35tonsillitis29.7LTA
36pancreatitis29.7IL10
37sarcoma29.7HSPA4
38trypanosomiasis10.5
39immune-complex glomerulonephritis10.4
40hemophagocytic lymphohistiocytosis10.2
41acquired immunodeficiency syndrome10.2
42erysipeloid10.2
43indeterminate leprosy10.2
44strongyloidiasis10.2
45felty's syndrome10.2
46leptospirosis10.2
47disseminated intravascular coagulation10.2
48syphilis10.2
49toxoplasmosis10.2
50sleeping sickness10.2

Graphical network of the top 20 diseases related to Leishmaniasis:



Diseases related to leishmaniasis

Clinical Features for Leishmaniasis

About this section
Sources:
46OMIM
See all sources

Clinical features from OMIM:

608207

Drugs & Therapeutics for Leishmaniasis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Leishmaniasis

Drug clinical trials:

Search ClinicalTrials for Leishmaniasis

Search NIH Clinical Center for Leishmaniasis

Search CenterWatch for Leishmaniasis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Leishmaniasis

About this section

Anatomical Context for Leishmaniasis

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Leishmaniasis:

32
Skin, Liver, Spleen, Bone, Bone marrow, T cells, Testes, Monocytes, Kidney, Whole blood, Lymph node, Pancreas, B cells, Salivary gland, Prostate, Colon, Smooth muscle, Endothelial, Myeloid, Brain, Spinal cord, Tonsil

Animal Models for Leishmaniasis or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Leishmaniasis:

36 (show all 14)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539711.5MPI, IFNGR1, SLC11A1, IL4, IL5, IL13
2MP:000538111.3SLC11A1, IFNG, IFNGR1, IL4, IL5, IL10
3MP:000538711.3LTA, IFNG, IFNGR1, SLC11A1, IL4, IL5
4MP:000538411.2LTA, IL4, IL13, MPI, FOXP3, TNF
5MP:000537011.2IL5, LTA, IL4, FOXP3, TNF, IFNGR1
6MP:001076811.2IFNG, HSPA4, SLC11A1, IL4, IL13, MPI
7MP:000537911.1HSPA4, TNF, FOXP3, LTA, IL4, IFNG
8MP:000538910.9IFNGR1, IL13, PGD
9MP:001077110.8CSN2, FOXP3, IL13
10MP:000200610.8IL5, IL10, TNF, IFNGR1, IFNG, SLC11A1
11MP:000538610.8TNF, LTA, PGD, IL10, IFNGR1, IFNG
12MP:000538810.7LTA
13MP:000363110.7PKD2L1, MPI, HSPA4, LTA
14MP:000539110.7MPI, FOXP3

Publications for Leishmaniasis

About this section
Sources:
50PubMed
See all sources

Articles related to Leishmaniasis:

(show top 50)    (show all 1602)
idTitleAuthorsYear
1
Mucocutaneous leishmaniasis as presentation of HIV infection in Sardinia, insular Italy. (24126182)
2014
2
Experimental infection of dogs with Leishmania and saliva as a model to study Canine Visceral Leishmaniasis. (23577121)
2013
3
Diagnosis of visceral leishmaniasis in Bihar India: comparison of the rK39 rapid diagnostic test on whole blood versus serum. (23717700)
2013
4
Comparative evaluation of blood and serum samples in rapid immunochromatographic tests for visceral leishmaniasis. (24048530)
2013
5
Interventions for American cutaneous and mucocutaneous leishmaniasis: a systematic review update. (23637917)
2013
6
Cutaneous leishmaniasis in a returning traveller. (23529965)
2013
7
Visceral leishmaniasis in a patient taking adalimumab for rheumatoid arthritis. (23545033)
2013
8
Reliable diagnosis of post-kala-azar dermal leishmaniasis (PKDL) using slit aspirate specimen to avoid invasive sampling procedures. (23279800)
2013
9
Degree of anemia correlates with increased utilization of heme by Leishmania donovani parasites in visceral leishmaniasis. (24076432)
2013
10
Comment on: leishmaniasis: an update of current pharmacotherapy. (23621855)
2013
11
Comparative analysis of pediatric and adult visceral leishmaniasis in Brazil. (23249921)
2013
12
Laboratory Evaluation of a Rodenticide-insecticide, CoumavecAr, against Rhombomys opimus, the Main Reservoir Host of Zoonotic Cutaneouse Leishmaniasis in Iran. (24409445)
2013
13
Occurrence of low density of Leishmania infantum in sandflies from a new focus of visceral leishmaniasis in northwest of Iran. (23995314)
2013
14
Urinary C reactive protein levels in dogs with leishmaniasis at different stages of renal damage. (23932765)
2013
15
Clinco-epidemiologic study of cutaneous leishmaniasis in Bikaner, Rajasthan, India. (23716414)
2013
16
One-year follow-up of immunocompetent male patients treated with miltefosine for primary visceral leishmaniasis in Bihar, India. (23943824)
2013
17
Making an anti-amastigote vaccine for visceral leishmaniasis: rational, update and perspectives. (22698479)
2012
18
Visceral Leishmaniasis Eradication is a Reality: Data from a Community-based Active Surveillance in Bangladesh. (23532674)
2012
19
Evaluation of an enzyme-linked immunosorbent assay based on crude Leishmania histone proteins for serodiagnosis of human infantile visceral leishmaniasis. (22815147)
2012
20
Post-kala-azar dermal leishmaniasis in visceral leishmaniasis-endemic communities in Bihar, India. (22882665)
2012
21
Immunity to visceral leishmaniasis using genetically defined live-attenuated parasites. (21912560)
2012
22
Drug donated for treatment of visceral leishmaniasis. (22389914)
2012
23
Peridomiciliary breeding sites of phlebotomine sand flies (Diptera: Psychodidae) in an endemic area of American cutaneous leishmaniasis in southeastern Brazil. (23091196)
2012
24
Identification of Leishmania tropica from micro-foci of cutaneous leishmaniasis in the Kenyan Rift Valley. (23265373)
2012
25
The efficacy of 5% trichloroacetic acid cream in the treatment of cutaneous leishmaniasis lesions. (21034291)
2012
26
Secreted virulence factors and immune evasion in visceral leishmaniasis. (22442494)
2012
27
Local or systemic treatment for New World cutaneous leishmaniasis? Re-evaluating the evidence for the risk of mucosal leishmaniasis. (24029394)
2012
28
Visceral leishmaniasis and arsenic: an ancient poison contributing to antimonial treatment failure in the Indian subcontinent? (21980542)
2011
29
Visceral leishmaniasis in renal transplant patient. (22198886)
2011
30
Cutaneous leishmaniasis in bam: a comparative evaluation of pre- and post-earthquake years (1999-2008). (23113072)
2011
31
Predictors of visceral leishmaniasis relapse in HIV-infected patients: a systematic review. (21666786)
2011
32
Glycosylation of erythrocyte spectrin and its modification in visceral leishmaniasis. (22164239)
2011
33
The changing profile of cutaneous leishmaniasis in a focus of the disease in Jahrom district, southern Iran. (20819305)
2010
34
Cutaneous leishmaniasis: advances in disease pathogenesis, diagnostics and therapeutics. (20831602)
2010
35
Some sociological aspects of cutaneous leishmaniasis in patients attending a tertiary referral centre in Colombo, Sri Lanka. (24037054)
2010
36
Plasma sCD26 and sCD30 levels in cutaneous leishmaniasis. (18983807)
2009
37
Pregnancy enhances the innate immune response in experimental cutaneous leishmaniasis through hormone-modulated nitric oxide production. (18347075)
2008
38
Arginase and polyamine synthesis are key factors in the regulation of experimental leishmaniasis in vivo. (15811879)
2005
39
Direct identification of Leishmania species in biopsies from patients with American tegumentary leishmaniasis. (12886810)
2003
40
Rare variants of Cutaneous Leishmaniasis: whitlow, paronychia, and sporotrichoid. (14521695)
2003
41
Acalculous cholecystitis in a patient with visceral leishmaniasis. (11816434)
2001
42
Decreased concentrations of CGRP in Leishmania major murine cutaneous leishmaniasis. (9792614)
1998
43
Human cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis in Santiago del Estero, Argentina: identification of parasites by monoclonal antibodies and isoenzymes. (9293087)
1996
44
Interleukin-12 restores interferon-gamma production and cytotoxic responses in visceral leishmaniasis. (8648233)
1996
45
Interferon gamma as an immunological strategy for the treatment of human leishmaniasis]. (7854095)
1994
46
Diffuse nodular regenerative hyperplasia of the liver associated with human immunodeficiency virus and visceral leishmaniasis. (8438854)
1993
47
Electrocardiographic alterations during treatment of mucocutaneous leishmaniasis with meglumine antimoniate and allopurinol. (1566297)
1992
48
Interferon gamma therapy for cutaneous leishmaniasis. (2111977)
1990
49
Mucocutaneous leishmaniasis--an unsolved clinical problem. (841692)
1977
50
The treatment of American (mucocutaneous) leishmaniasis with amphotericin B. (13745957)
1960

Genetic Variations for Leishmaniasis

About this section

Expression for genes affiliated with Leishmaniasis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Leishmaniasis

Search GEO for disease gene expression data for Leishmaniasis.

Pathways for genes affiliated with Leishmaniasis

About this section
Sources:
29KEGG, 51QIAGEN, 12EMD Millipore, 37NCBI BioSystems Database, 52R&D Systems, 53Reactome
See all sources

Pathways related to Leishmaniasis according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.1IFNG, IFNGR1, TNF, HSPA4, LTA, IL4
210.9IL13, LTA, TNF, IFNG, IL10, IL5
310.9IL13, IL4, IL5, IFNG, LTA, IL10
410.9IL4, IL5, IL10, IL13, IFNG, IFNGR1
5
Hide members
10.9IL10, IL5, IL4, IL13, LTA, TNF
6
Hide members
10.9LTA, IL13, IL4, IFNGR1, TNF, IFNG
7
Hide members
10.9IL4, IL5, TNF, IL13, IFNGR1, IFNG
8
Hide members
10.8IL4, IFNG, TNF, IL10, IL5
9
Hide members
10.8LTA, TNF, IFNG, IFNGR1, IL10
10
Hide members
10.8IL5, FOXP3, TNF, IL4, IFNG
1110.8CSN2, IL4, IL5, IL13, IFNG
12
Hide members
10.8IFNG, IL4, TNF, IFNGR1, CSN2
13
Hide members
10.8HSPA4, IFNG, IFNGR1, TNF, LTA
1410.7IL4, IL5, LTA, IL10
15
Hide members
10.7FOXP3, TNF, IL10, IFNG
16
Hide members
10.7TNF, IFNGR1, IFNG, IL10
1710.7IL10, TNF, IFNGR1, IFNG
18
Hide members
10.7TNF, IFNG, IFNGR1, LTA
19
Hide members
10.7IL13, IL5, FOXP3, IFNGR1
20
Hide members
10.7IFNGR1, CXCR1, IL13, IL5
2110.7IFNG, IL4, IL5
2210.7IL10, IFNG, TNF
2310.7IL13, IL5, IL4
2410.7IL4, TNF, IL5
25
Hide members
10.7IL5, IL13, LTA
26
Hide members
10.7LTA, IL13, IL5
27
Hide members
10.7IL4, LTA, FOXP3
28
Immune response Bacterial infections in normal airways
10.7IFNGR1, IFNG, TNF

Compounds for genes affiliated with Leishmaniasis

About this section
Sources:
44Novoseek, 11DrugBank, 24HMDB, 59Tocris Bioscience, 49PharmGKB, 28IUPHAR
See all sources

Compounds related to Leishmaniasis according to GeneCards/GeneDecks:

(show top 50)    (show all 124)
idCompoundScoreTop Affiliating Genes
1nitric oxide44 11 2413.5IL13, IL10, SLC11A1, PGD, LTA, MT-CYB
2vegf4411.4CXCR1, IL5, IL4, IL10, IL13, LTA
3il 104411.4TNF, IL13, IL10, IL5, IL4, IFNG
4tarc4411.4IL10, IL5, IFNG, TNF, CXCR1, IL13
5ionomycin4411.4IL4, IL5, IL13, IFNG, TNF, LTA
6herbimycin a44 5912.4IFNG, HSPA4, TNF, LTA, CXCR1, IL4
7il-124411.3IL5, TNF, IFNG, IL10, IL4, IL13
8sb 20358044 5912.3IL13, IFNG, HSPA4, TNF, IL10, IL5
9allergens4411.3IL5, IFNG, IL10, CSN2, IL13, IL4
10dexamethasone44 49 28 1114.3IL5, CXCR1, LTA, CSN2, HSPA4, IL13
11glatiramer acetate44 1112.3IL10, IL13, IL4, IFNG, IL5
12rantes4411.2LTA, IFNG, CXCR1, TNF, IL4
13aspartate4411.2PGD, MT-CYB, HSPA4, MDH2, MPI, SLC11A1
14okt34411.2IFNG, IL4, IL10, TNF, LTA
15thyroxine44 2412.2LTA, IL13, IL5, IL4, IL10, HSPA4
16budesonide44 49 1113.2TNF, IL13, IFNG, IL4, IL5
17actinomycin d4411.2CXCR1, HSPA4, IL4, IFNG, TNF, LTA
18fluticasone propionate44 49 59 1114.2IFNG, IL4, TNF, IL13, IL5
19polyinosinic-polycytidylic acid4411.2IFNG, IL5, IL10, IL4, TNF
20infliximab44 49 1113.2IL10, LTA, TNF, IFNG, IL4
21tacrolimus44 49 1113.2IFNG, TNF, IL13, IL10, IL5, IL4
22interferon gamma4411.2IL4, IL10, IFNG, TNF
23ccl344 2812.1IFNG, CXCR1, IL10, IL13, TNF
24alpha-galactosylceramide4411.1IFNG, IL4, IL10, IL13
25neopterin4411.1IL4, LTA, TNF, IL10, IFNG
26calcitriol44 59 11 2414.1IL4, IL10, TNF, IL13, LTA, IFNG
27h2o24411.1PGD, HSPA4, MDH2, MT-CYB, LTA, IL13
28gm-csf44 2812.1TNF, IL10, IFNG
29cycloheximide4411.1LTA, MT-CYB, LMLN
30mip 1alpha4411.1IL10, IL4, TNF, IL13
3115-deoxy-delta-12,14-prostaglandin j24411.1IFNG, TNF, IL4, HSPA4, IL10
32pentoxifylline44 1112.1IL13, IL4, LTA
33praziquantel44 1112.1IL5, IL4, IL10, IL13
34cyclosporin a44 28 5913.1LTA, IFNG, FOXP3
35prednisolone44 28 1113.1LTA, IL13, IL5
36lactate4411.0TNF, IL13, PGD, LTA, MDH2, CSN2
37thalidomide44 49 59 1114.0IL13, IL10, IFNG, TNF, IL5
38indomethacin44 59 28 1114.0IL5, HSPA4
39fmlp4411.0IL13, IL5, MT-CYB
40ivig4411.0IFNG
41imiquimod44 28 59 1113.9TNF, IFNG, IL10, IL5
42montelukast44 49 28 1113.9IL4, IL5, IL10, IL13
43polymyxin b4410.9IL4, TNF, IL10, IFNG
44amphotericin b4410.9IL13
45groalpha4410.8IL10, IL13, CXCR1, TNF
46indoleamine4410.8IL13
47con a4410.7IFNG, IL5, IL4, IL10
48betaseron4410.7IL4, IL10, IFNG
49omalizumab44 1111.6IL4, IL5, IL13
50superoxide44 2411.5MT-CYB, TNF, MDH2, MPI, PGD

GO Terms for genes affiliated with Leishmaniasis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Leishmaniasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.7IL4, IL13, TNF, IFNG
2extracellular spaceGO:00561510.6IL4, IFNG, TNF, LTA, IL13, IL10

Biological processes related to Leishmaniasis according to GeneCards/GeneDecks:

(show all 30)
idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:00695411.2SLC11A1, TNF, CXCR1, IL13, IL10, IL5
2response to drugGO:04249311.2IL10, LTA, IFNG, TNF, IL4
3negative regulation of growth of symbiont in hostGO:04413011.1TNF, IFNG, LTA, IL10
4positive regulation of sequence-specific DNA binding transcription factor activityGO:05109111.1IL4, IL5, IL10, TNF
5positive regulation of transcription from RNA polymerase II promoterGO:04594411.1IL10, FOXP3, TNF, IFNG, SLC11A1, IL4
6positive regulation of MHC class II biosynthetic processGO:04534811.1IL4, IL10, IFNG
7response to virusGO:00961511.1FOXP3, IFNG, TNF, IFNGR1
8positive regulation of chemokine biosynthetic processGO:04508011.1IL4, TNF, IFNG
9defense response to protozoanGO:04283211.1IL4, IFNG, SLC11A1
10negative regulation of interleukin-6 productionGO:03271511.0TNF, FOXP3, IL10
11protein import into nucleus, translocationGO:00006011.0IFNG, SLC11A1, TNF
12positive regulation of B cell proliferationGO:03089011.0IL5, IL13, IL4
13positive regulation of interferon-gamma productionGO:03272911.0TNF, LTA, SLC11A1
14positive regulation of vitamin D biosynthetic processGO:06055711.0IFNG, TNF
15positive regulation of chronic inflammatory response to antigenic stimulusGO:00287610.9LTA, TNF
16humoral immune responseGO:00695910.9LTA, IFNG, TNF
17negative regulation of chronic inflammatory responseGO:00267710.9IL4, FOXP3
18regulation of isotype switchingGO:04519110.9IL4, IL10
19receptor biosynthetic processGO:03280010.9IL10, TNF
20positive regulation of calcidiol 1-monooxygenase activityGO:06055910.9IFNG, TNF
21type 2 immune responseGO:04209210.9IL10, IL4
22regulation of proton transportGO:01015510.8IL13, IL4
23negative regulation of cytokine secretion involved in immune responseGO:00274010.8IL10, TNF
24positive regulation of podosome assemblyGO:07180310.8TNF, IL5
25positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.7LTA, TNF
26positive regulation of transcription, DNA-dependentGO:04589310.7IL10, IL5, IL4, TNF, FOXP3
27positive regulation of isotype switching to IgG isotypesGO:04830410.7IL4, IFNG
28positive regulation of membrane protein ectodomain proteolysisGO:05104410.6IFNG, TNF
29positive regulation of immunoglobulin productionGO:00263910.6FOXP3, IL13
30negative regulation of nitric oxide biosynthetic processGO:04501910.3IL4, IL10

Molecular functions related to Leishmaniasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.9IL4, IL5, IL10, IL13, LTA, TNF

Products for genes affiliated with Leishmaniasis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Leishmaniasis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet