MCID: LSH001
MIFTS: 74

Leishmaniasis malady

Rare diseases, Infectious diseases categories
Download this MalaCard

Summaries for Leishmaniasis

About this section


Fully expand this MalaCard
MedlinePlus:33 Leishmaniasis is a parasitic disease spread by the bite of infected sand flies. there are several different forms of leishmaniasis. the most common are cutaneous and visceral. the cutaneous type causes skin sores. the visceral type affects internal organs such as the spleen, liver, and bone marrow. people with this form usually have fever, weight loss, and an enlarged spleen and liver. leishmaniasis is found in parts of about 88 countries. most of these countries are in the tropics and subtropics. it is possible but very unlikely that you would get this disease in the united states. but you should be aware of it if you are traveling to the middle east or parts of central america, south america, asia, africa or southern europe. treatment is with medicines that contain antimony, a type of metal, or with strong antibiotics. the best way to prevent the disease is to protect yourself from sand fly bites: stay indoors from dusk to dawn, when sand flies are the most active wear long pants and long-sleeved shirts when outside use insect repellent and bed nets as needed centers for disease control and prevention

MalaCards based summary: Leishmaniasis, also known as kala-azar, is related to cutaneous leishmaniasis and mucocutaneous leishmaniasis. An important gene associated with Leishmaniasis is IFNG (interferon, gamma), and among its related pathways are Inflammatory Response Pathway and Immune response IL 23 signaling pathway. The drugs ketoconazole and itraconazole and the compounds alpha-galactosylceramide and interferon gamma have been mentioned in the context of this disorder. Affiliated tissues include skin, bone marrow and bone, and related mouse phenotypes are craniofacial and tumorigenesis.

Disease Ontology:8 A parasitic protozoa infectious disease that involves infection caused by protozoan parasite of the genus leishmania, which is transmitted by the bite of sand fly (subfamily phlebotominae).

NIH Rare Diseases:42 Leishmaniasis is a parasitic disease spread by the bite of infected sand flies. there are several different forms of leishmaniasis. the most common are cutaneous and visceral. the cutaneous type causes skin sores. the visceral type affects internal organs such as the spleen, liver and bone marrow. people with this form usually have fever, weight loss, and an enlarged spleen and liver. visceral disease can be deadly without proper treatment. leishmaniasis is found in parts of the middle east, central america, south american, asia, africa, and southern europe. most of these countries are in the tropics and subtropics. it is possible but very unlikely to get this disease in the united states. last updated: 7/6/2011

CDC:3 Leishmaniasis is a parasitic disease that is found in parts of the tropics, subtropics, and southern Europe. It is classified as a Neglected Tropical Disease (NTD). Leishmaniasis is caused by infection with Leishmania parasites, which are spread by the bite of phlebotomine sand flies. There are several different forms of leishmaniasis in people. The most common forms are cutaneous leishmaniasis, which causes skin sores, and visceral leishmaniasis, which affects several internal organs (usually spleen, liver, and bone marrow).

Wikipedia:65 Leishmaniasis (/?li??m??na??s?s/) or leishmaniosis (/li???me?n??o?s?s/ or /li???m more...

Description from OMIM:46 608207

Aliases & Classifications for Leishmaniasis

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 46OMIM, 33MedlinePlus, 62UMLS, 27ICD9CM, 39NCIt, 57SNOMED-CT, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

Leishmaniasis, Aliases & Descriptions:

Name: Leishmaniasis 8 42 10 44 48 46 33 62
Kala-Azar 42 62
Leishmaniasis, Cutaneous 62
 
Leishmaniasis, Visceral 62
Cutaneous Leishmaniasis 42
Visceral Leishmaniasis 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases


Characteristics (Orphanet epidemiological data):

48
leishmaniasis:
Inheritance: Sporadic; Prevalence: 1-9/1000000; Age of onset: Variable


External Ids:

Disease Ontology8 DOID:9065
ICD9CM27 085.9, 085
NCIt39 C34767
MeSH34 D007896
OMIM46 608207
MESH via Orphanet35 D007896
ICD10 via Orphanet26 B55.0, B55.1, B55.2 B55.9, more
UMLS via Orphanet63 C0023281

Related Diseases for Leishmaniasis

About this section

Diseases related to Leishmaniasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 226)
idRelated DiseaseScoreTop Affiliating Genes
1cutaneous leishmaniasis32.6IFNG, IL10
2mucocutaneous leishmaniasis32.3PKD2L1
3visceral leishmaniasis31.9LMLN, PGD, IFNG, IL4, IL10, SLC11A1
4leprosy31.5SLC11A1
5strongyloidiasis31.1IL5
6tuberculoid leprosy31.0IFNG, IL10
7lepromatous leprosy30.6LTA, IL10, IL4, IFNG
8filariasis30.4IL13, IL5
9psoriatic arthritis30.4IL13, TNF
10aspergillosis30.4MT-CYB, IFNG
11uveitis30.2TNF, CXCR1, IFNG, IL4, IL10, LTA
12pulmonary sarcoidosis30.2TNF, IFNG, LTA
13lymphopenia30.1FOXP3, IFNG, IL4, IL10
14malaria30.1TNF, HSPA4, MT-CYB, IFNGR1, IFNG, IL10
15chronic granulomatous disease30.1MT-CYB, IFNG
16dermatitis30.0FOXP3, IFNG, IL4, IL5, IL13
17connective tissue disease29.9TNF, FOXP3, IL4, IL10
18sepsis29.8TNF, CXCR1, IL10, LTA
19schistosomiasis29.6IFNGR1, IFNG, IL4, IL5, IL10, IL13
20systemic lupus erythematosus29.5TNF, IFNGR1, IFNG, IL4, IL10, LTA
21pulmonary tuberculosis29.5CXCR1, IFNGR1, IFNG, IL4, IL10, SLC11A1
22sarcoidosis29.5TNF, HSPA4, IFNGR1, IFNG, IL13, SLC11A1
23arthritis29.5TNF, CXCR1, FOXP3, IFNG, IL4, IL10
24tuberculosis29.5TNF, HSPA4, CXCR1, IFNGR1, IFNG, IL4
25rheumatoid arthritis29.3TNF, CXCR1, FOXP3, IFNG, IL4, IL10
26psoriasis29.2TNF, CXCR1, IFNG, IL4, IL5, IL10
27leukemia29.2TNF, HSPA4, CXCR1, FOXP3, IFNG, IL4
28periapical granuloma10.6IL4
29trypanosomiasis10.6
30eosinophilic fasciitis10.5IL5
31intraocular lymphoma10.5IL10
32chagas disease10.5
33meniere's disease10.5HSPA4
34vulvovaginitis10.5HSPA4
35kimura disease10.5IL5
36eosinophilia-myalgia syndrome10.5IL5
37eosinophilic esophagitis10.5IL5
38autosomal dominant hyper ige syndrome10.4IL4, IFNG
39omenn syndrome10.4IL4, IL5
40blau syndrome10.4TNF
41immune-complex glomerulonephritis10.4
42kala-azar 210.4
43kala-azar 310.4
44kala-azar 110.4
45keratoconjunctivitis10.4IL5, IL13
46mycobacterium avium complex disease10.4IFNGR1
47egg allergy10.4IL4, IL5
48relapsing-remitting multiple sclerosis10.4IL10, IFNG
49intrinsic asthma10.4IL5, IL4
50allergic bronchopulmonary aspergillosis10.4IL5, IL4

Graphical network of the top 20 diseases related to Leishmaniasis:



Diseases related to leishmaniasis

Symptoms for Leishmaniasis

About this section


Clinical features from OMIM:

608207

Drugs & Therapeutics for Leishmaniasis

About this section

Drug clinical trials:

Search ClinicalTrials for Leishmaniasis

Search NIH Clinical Center for Leishmaniasis

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Leishmaniasis

About this section

Anatomical Context for Leishmaniasis

About this section

MalaCards organs/tissues related to Leishmaniasis:

32
Skin, Bone marrow, Bone, Liver, Spleen, T cells, Testes, Monocytes, Kidney, Whole blood, Lymph node, Brain, Pancreas, B cells, Neutrophil, Spinal cord, Smooth muscle, Colon, Salivary gland, Prostate, Tonsil, Myeloid, Nk cells

Animal Models for Leishmaniasis or affiliated genes

About this section

MGI Mouse Phenotypes related to Leishmaniasis:

36 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053829.1IL10, IL4, IFNG, FOXP3, TNF
2MP:00020069.1TNF, IFNGR1, IFNG, IL5, IL10, SLC11A1
3MP:00030128.9TNF, FOXP3, IFNG, IL4, IL10, IL13
4MP:00053908.8TNF, IFNGR1, IFNG, IL4, IL10, LTA
5MP:00053918.8TNF, MPI, FOXP3, IFNG, IL4, IL10
6MP:00107718.7TNF, FOXP3, IFNGR1, IFNG, IL4, IL10
7MP:00053888.6TNF, FOXP3, IFNG, IL4, IL5, IL10
8MP:00053708.5TNF, FOXP3, IFNGR1, IFNG, IL4, IL5
9MP:00053808.5TNF, MPI, IFNGR1, IFNG, IL5, IL10
10MP:00053858.4TNF, MPI, FOXP3, IFNGR1, IFNG, IL10
11MP:00053818.3SLC11A1, TNF, FOXP3, IFNGR1, IFNG, IL4
12MP:00053788.2TNF, MPI, FOXP3, IFNG, IL4, IL5
13MP:00053768.1TNF, FOXP3, IFNGR1, IFNG, IL4, IL5
14MP:00053798.0TNF, HSPA4, FOXP3, IFNGR1, IFNG, IL4
15MP:00053878.0TNF, FOXP3, IFNGR1, IFNG, IL4, IL5
16MP:00053867.9TNF, HSPA4, PGD, FOXP3, IFNGR1, IFNG
17MP:00053847.9TNF, HSPA4, MPI, FOXP3, IFNGR1, IFNG
18MP:00053897.8TNF, HSPA4, PGD, FOXP3, IFNGR1, IFNG
19MP:00053977.7IFNGR1, FOXP3, MPI, TNF, IFNG, IL4
20MP:00036317.7TNF, HSPA4, MPI, IFNGR1, IFNG, IL4
21MP:00107687.4FOXP3, MPI, HSPA4, TNF, IFNGR1, IFNG

Publications for Leishmaniasis

About this section

Articles related to Leishmaniasis:

(show top 50)    (show all 1639)
idTitleAuthorsYear
1
Evaluation of the immunoprophylactic potential of a killed vaccine candidate in combination with different adjuvants against murine visceral leishmaniasis. (25316605)
2014
2
Zosteriform cutaneous leishmaniasis. (25396096)
2014
3
Cutaneous leishmaniasis responds to daylight-activated photodynamic therapy: Proof-of-concept for a novel self-administered therapeutic modality. (25363817)
2014
4
Cutaneous Leishmaniasis Mimicking A Pyogenic Granuloma. (24923493)
2014
5
Visceral leishmaniasis in Brazil: rationale and concerns related to reservoir control. (25372177)
2014
6
Treatment-based strategy for the management of post-kala-azar dermal leishmaniasis patients in the Sudan. (23690794)
2013
7
Experimental infection of dogs with Leishmania and saliva as a model to study Canine Visceral Leishmaniasis. (23577121)
2013
8
Molecular diagnosis of leishmaniasis at the subgenus and species level. (24189975)
2013
9
Atypical presentation of cutaneous leishmaniasis in a renal transplant recipient successfully treated with allopurinol and fluconazole. (22750767)
2013
10
Pentalinon andrieuxii Root Extract is Effective in the Topical Treatment of Cutaneous Leishmaniasis Caused by Leishmania mexicana. (24347110)
2013
11
Clinical findings and management of imported cutaneous leishmaniasis: report of 14 cases from Austria. (23522841)
2013
12
Ecology of leishmaniasis in the South of France. 22. Reliability and representativeness of 12 Phlebotomus ariasi, P. perniciosus and Sergentomyia minuta (Diptera: Psychodidae) sampling stations in Vallespir (eastern French Pyrenees region). (24112589)
2013
13
What is responsible for a large and unusual outbreak of leishmaniasis in Madrid? (24275160)
2013
14
Role of fine-needle aspiration cytology in the prompt diagnosis of recurrence of visceral leishmaniasis presented as isolated cervical leishmanial lymphadenopathy. (21671412)
2013
15
Effect of 3-alkylpyridine marine alkaloid analogues in Leishmania species related to American cutaneous leishmaniasis. (22882996)
2012
16
Factors associated with asymptomatic infection in family members and neighbors of patients with visceral leishmaniasis. (23288063)
2012
17
Killed but metabolically active Leishmania infantum as a novel whole-cell vaccine for visceral leishmaniasis. (22323556)
2012
18
Prevalence, features and risk factors for malaria co-infections amongst visceral leishmaniasis patients from Amudat Hospital, Uganda. (22506087)
2012
19
Comparative study of rK39 Leishmania antigen for serodiagnosis of visceral leishmaniasis: systematic review with meta-analysis. (22303488)
2012
20
Recent advances in development of amphotericin B formulations for the treatment of visceral leishmaniasis. (23147810)
2012
21
Resistance to visceral leishmaniasis is severely compromised in mice deficient of bradykinin B2-receptors. (23151408)
2012
22
Distinct pattern of immunophenotypic features of innate and adaptive immunity as a putative signature of clinical and laboratorial status of patients with localized cutaneous leishmaniasis. (22823491)
2012
23
The knowledge, attitude, and prevention practices of students regarding cutaneous leishmaniasis in the hyperendemic region of the Shahid Babaie Airbase. (22022818)
2012
24
Asymptomatic carriage of Leishmania in family members of patients with visceral leishmaniasis in Central Tunisia. (22154335)
2012
25
Latency time in cutaneous leishmaniasis. (21505401)
2011
26
IL-27 and IL-21 are associated with T cell IL-10 responses in human visceral leishmaniasis. (21357266)
2011
27
PKCI' regulates IL-12p40/p70 production by macrophages and dendritic cells, driving a type 1 healer phenotype in cutaneous leishmaniasis. (21287553)
2011
28
First report on natural infection of Phlebotomus sergenti with Leishmania promastigotes in the cutaneous leishmaniasis focus in southeastern Tunisia. (21976566)
2011
29
Canine visceral leishmaniasis: study of methods for the detection of IgG in serum and eluate samples. (21748226)
2010
30
Sand fly Surveillance within an Emerging Epidemic Focus of Cutaneous Leishmaniasis in Southeastern Iran. (22808384)
2010
31
Treatment of acute cutaneous leishmaniasis with intralesional injection of meglumine antimoniate: comparison of conventional technique with mesotherapy gun. (20883265)
2010
32
CD8+ T cells as a source of IFN-I^ production in human cutaneous leishmaniasis. (20967288)
2010
33
Comparison of three methods for diagnosis of cutaneous leishmaniasis. (22347259)
2010
34
Study of sand fly fauna in an endemic area of American cutaneous leishmaniasis and canine visceral leishmaniasis in the municipality of EspA-rito Santo do Pinhal, SALo Paulo, Brazil. (20428683)
2010
35
Immunophenotypic pattern and cytokine profiles of dry type cutaneous leishmaniasis. (19566354)
2009
36
IFN-beta impairs superoxide-dependent parasite killing in human macrophages: evidence for a deleterious role of SOD1 in cutaneous leishmaniasis. (19201909)
2009
37
Anti-iL-10 mAb protection against experimental visceral leishmaniasis via induction of Th1 cytokines and nitric oxide. (19634715)
2009
38
Relapsing cutaneous leishmaniasis in a patient with ankylosing spondylitis treated with infliximab. (19556566)
2009
39
Treatment of mucosal leishmaniasis in Latin America: systematic review. (17690398)
2007
40
Report of an atypical case of leishmaniasis presented as acute tonsillitis in an immunocompetent patient. (16308231)
2005
41
Adenosine deaminase activity in sera of patients with visceral leishmaniasis in Nepal. (15970028)
2005
42
Mucocutaneous leishmaniasis: an imported infection among travellers to central and South America. (15472268)
2004
43
Recent advances in research and control of malaria, leishmaniasis, trypanosomiasis and schistosomiasis. (15748049)
2003
44
Rhabdomyolysis induced by pentamidine (Pentacarinat) during treatment of cutaneous leishmaniasis: 2 cases]. (11937930)
2002
45
Chronic dacryocystitis in American mucocutaneous leishmaniasis. (11206745)
2001
46
In situ expression of interleukin-10 and interleukin-12 in active human cutaneous leishmaniasis. (8880134)
1996
47
Polymorphism in tumor necrosis factor genes associated with mucocutaneous leishmaniasis. (7595196)
1995
48
CD23 and IgE expression during the human immune response to cutaneous leishmaniasis: possible role in monocyte activation. (8008965)
1994
49
Treatment of visceral leishmaniasis with pentavalent antimony and interferon gamma. (2104665)
1990
50
Mucocutaneous leishmaniasis--an unsolved clinical problem. (841692)
1977

Variations for Leishmaniasis

About this section

Expression for genes affiliated with Leishmaniasis

About this section
Expression patterns in normal tissues for genes affiliated with Leishmaniasis

Search GEO for disease gene expression data for Leishmaniasis.

Pathways for genes affiliated with Leishmaniasis

About this section

Pathways related to Leishmaniasis according to GeneCards/GeneDecks:

(show all 41)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8IFNG, IL4, IL5
2
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.8IL10, IFNG, TNF
39.8TNF, IFNG, IL10
49.8TNF, IFNG, IL10
59.8IL10, IFNG, TNF
69.8IL4, IFNG, TNF
79.7IL13, IL5, IL4
89.7TNF, IL10, IL13
9
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway60
9.7LTA, IL4, TNF
109.7IL5, IL4, TNF
119.6IL10, IL4, FOXP3
12
Show member pathways
Immune response MIF in innate immunity response60
9.6TNF, IFNGR1, IFNG
139.6TNF, IFNGR1, IFNG
149.6TNF, IFNGR1, IFNG
15
Show member pathways
IL2 signaling events mediated by STAT537
9.6LTA, IL4, FOXP3
169.5IFNG, IL4, IL5, IL13
179.5IL4, IL5, IL10, LTA
18
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells37
9.4TNF, IL4, IL5, IL13
19
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
9.4IL10, IFNG, IFNGR1, TNF
209.4IL10, IFNG, IFNGR1, TNF
21
Show member pathways
9.4IL4, IFNG, IFNGR1, TNF
22
Show member pathways
Immune response CD16 signaling in NK cells60
9.4TNF, IFNGR1, IFNG, IL4
23
Show member pathways
9.4IL10, IFNG, FOXP3, TNF
24
Show member pathways
9.3TNF, IFNGR1, IFNG, LTA
25
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
9.3TNF, IFNG, IL4, IL5, IL10
26
Show member pathways
IL27-mediated signaling events37
9.1TNF, IFNGR1, IFNG, IL10, LTA
27
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.1TNF, IFNGR1, IFNG, IL4, LTA
28
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
9.1TNF, FOXP3, IFNG, IL4, IL5
299.0IFNG, IL4, IL5, IL10, IL13, LTA
309.0TNF, IFNG, IL4, IL5, IL10, IL13
31
Show member pathways
8.9TNF, IL4, IL5, IL10, IL13, LTA
32
Show member pathways
8.9TNF, IL4, IL5, IL10, IL13, LTA
33
Show member pathways
8.9TNF, IL4, IL5, IL10, IL13, LTA
34
Show member pathways
Type III interferon signaling37
8.9IFNGR1, IFNG, IL4, IL5, IL10, IL13
35
Show member pathways
8.9TNF, IFNGR1, IFNG, IL4, IL13, LTA
36
Show member pathways
8.8TNF, HSPA4, IFNGR1, IFNG, LTA
378.7LTA, TNF, IFNG, IL4, IL5, IL10
38
Show member pathways
8.4TNF, IFNGR1, IFNG, IL4, IL5, IL10
39
Show member pathways
8.2TNF, FOXP3, IFNGR1, IFNG, IL4, IL5
40
Show member pathways
7.9TNF, CXCR1, IFNGR1, IFNG, IL4, IL5
41
Show member pathways
7.8TNF, HSPA4, IFNGR1, IFNG, IL4, IL5

Compounds for genes affiliated with Leishmaniasis

About this section

Compounds related to Leishmaniasis according to GeneCards/GeneDecks:

(show top 50)    (show all 150)
idCompoundScoreTop Affiliating Genes
1alpha-galactosylceramide4410.0IL4, IFNG, IL10, IL13
2interferon gamma449.9IFNG, TNF, IL4, IL10
3mip 1alpha449.8IL4, IL13, TNF, IL10
4praziquantel44 1110.8IL4, IL5, IL10, IL13
5glatiramer acetate44 1110.7IL13, IL10, IL5, IL4, IFNG
6amphotericin b449.7IL13, IFNG, IL4, IL5
7okt3449.7LTA, IL10, IL4, IFNG, TNF
8indoleamine449.7IFNG, TNF, IL10, IL13
9polyinosinic-polycytidylic acid449.6IL4, IL5, IL10, IFNG, TNF
10infliximab44 50 1111.6IL10, IL4, LTA, IFNG, TNF
11montelukast44 50 28 1112.6IL10, IL13, IL5, IL4
12budesonide44 50 1111.6TNF, IL13, IL5, IL4, IFNG
13fluticasone propionate44 50 61 1112.6IFNG, IL13, IL5, IL4, TNF
14neopterin449.6TNF, IFNG, LTA, IL10, IL4
15allergens449.6IFNG, IL10, IL4, IL5, IL13
16con a449.6IFNG, IL4, IL5, IL10
17imiquimod44 61 28 1112.5TNF, IFNG, IL10, IL5
18il-12449.5IL5, IL4, IL13, TNF, IL10, IFNG
19gm-csf44 2810.4IL5, IFNG, TNF, IL4, IL10, IL13
20pentoxifylline44 1110.4TNF, IL13, IFNG, IL10, IL4, LTA
21polymyxin b449.4TNF, IFNG, IL10, IL4
22rolipram44 61 2811.4IL13, TNF, IFNG, IL4, IL5, IL10
23thalidomide44 50 61 1112.4IL13, IL5, IFNG, TNF, IL10
24ivig449.4LTA, IL10, IL5, IFNG, TNF, IL4
25ccl344 2810.4CXCR1, IFNG, IL10, IL13, TNF
26hydrocortisone44 2 61 1112.4IL13, IL10, IL5, IL4, TNF, IFNG
27prednisolone44 28 1111.3IL10, IFNG, IL5, LTA, TNF, IL13
28rantes449.3IFNG, CXCR1, IL5, IL10, IL13, IL4
2915-deoxy-delta-12,14-prostaglandin j2449.3IFNG, TNF, HSPA4, IL4, IL10
30tacrolimus44 50 1111.3IL13, TNF, IFNG, IL4, IL5, IL10
31calcitriol44 61 24 1112.3IL10, IL4, TNF, IFNG, LTA, IL13
32il 10449.2IL5, IL10, IL13, LTA, TNF, IFNG
33ionomycin449.2IL10, IL13, LTA, IFNG, IL5, IL4
34endotoxin449.1CXCR1, TNF, IFNG, LTA, IL10, IL13
35thyroxine44 2410.1LTA, IL13, IL10, IL4, HSPA4, IL5
36tarc449.0IL4, IL5, IL10, IL13, TNF, IFNG
37groalpha449.0TNF, CXCR1, IL10, IL13
38fmlp448.9CXCR1, MT-CYB, IL5, IL13, LTA, TNF
39sb 20358044 619.9HSPA4, TNF, IL13, IFNG, IL4, IL5
40indomethacin44 28 61 1111.8HSPA4, IFNG, LTA, IL13, TNF, IL4
41thymidine44 249.8IL13, IFNG, IL10, IL5, TNF, IL4
42cyclosporin a44 28 6110.7TNF, LTA, IL13, IL10, IL5, IFNG
43pge2448.7FOXP3, IFNG, IL5, IL10, IL13, LTA
44herbimycin a44 619.6IL5, IFNG, CXCR1, HSPA4, TNF, LTA
45actinomycin d448.6IL4, CXCR1, HSPA4, TNF, LTA, IL13
46aspartate448.4HSPA4, MT-CYB, PGD, IL10, IL13, SLC11A1
47dexamethasone44 50 28 1111.2IL10, IL4, IFNG, CXCR1, HSPA4, TNF
48vegf448.1LTA, IL10, CXCR1, HSPA4, TNF, IL4
49nitric oxide44 24 119.9LTA, SLC11A1, IL13, TNF, HSPA4, PGD
50cycloheximide447.3LTA, TNF, HSPA4, LMLN, CXCR1, IL5

GO Terms for genes affiliated with Leishmaniasis

About this section

Cellular components related to Leishmaniasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.5IL13, IL4, IFNG, TNF
2extracellular spaceGO:0056158.4LTA, TNF, IFNG, IL4, IL5, IL10

Biological processes related to Leishmaniasis according to GeneCards/GeneDecks:

(show all 37)
idNameGO IDScoreTop Affiliating Genes
1regulation of isotype switchingGO:04519110.4IL4, IL10
2type 2 immune responseGO:04209210.4IL10, IL4
3positive regulation of vitamin D biosynthetic processGO:06055710.4TNF, IFNG
4positive regulation of calcidiol 1-monooxygenase activityGO:06055910.3TNF, IFNG
5positive regulation of isotype switching to IgG isotypesGO:04830410.3IFNG, IL4
6receptor biosynthetic processGO:03280010.3TNF, IL10
7regulation of proton transportGO:01015510.3IL4, IL13
8positive regulation of chronic inflammatory response to antigenic stimulusGO:00287610.3TNF, LTA
9positive regulation of MHC class II biosynthetic processGO:04534810.3IL10, IL4, IFNG
10negative regulation of nitric oxide biosynthetic processGO:04501910.2IL10, IL4
11negative regulation of cytokine secretion involved in immune responseGO:00274010.2TNF, IL10
12defense response to protozoanGO:04283210.2SLC11A1, IL4, IFNG
13positive regulation of podosome assemblyGO:07180310.2TNF, IL5
14negative regulation of chronic inflammatory responseGO:00267710.2FOXP3, IL4
15positive regulation of chemokine biosynthetic processGO:04508010.2TNF, IFNG, IL4
16positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.1TNF, LTA
17protein import into nucleus, translocationGO:00006010.1SLC11A1, IFNG, TNF
18positive regulation of membrane protein ectodomain proteolysisGO:05104410.1IFNG, TNF
19positive regulation of B cell proliferationGO:03089010.1IL13, IL5, IL4
20positive regulation of immunoglobulin productionGO:00263910.0IL13, FOXP3
21positive regulation of interferon-gamma productionGO:03272910.0TNF, SLC11A1, LTA
22defense response to bacteriumGO:04274210.0IFNG, IL10, SLC11A1
23humoral immune responseGO:00695910.0LTA, IFNG, TNF
24regulation of interferon-gamma-mediated signaling pathwayGO:06033410.0IFNG, IFNGR1
25positive regulation of cytokine secretionGO:05071510.0IL10, TNF
26negative regulation of interleukin-6 productionGO:03271510.0IL10, FOXP3, TNF
27positive regulation of cytokine productionGO:0018199.9SLC11A1, TNF
28negative regulation of growth of symbiont in hostGO:0441309.9LTA, IL10, IFNG, TNF
29positive regulation of osteoclast differentiationGO:0456729.9TNF, IFNG
30positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.9TNF, IL4, IL5, IL10
31response to lipopolysaccharideGO:0324969.8IL13, SLC11A1, LTA
32response to drugGO:0424939.7TNF, IFNG, IL4, IL10, LTA
33response to virusGO:0096159.6TNF, FOXP3, IFNGR1, IFNG
34negative regulation of interferon-gamma productionGO:0326899.6IL10, FOXP3
35positive regulation of transcription, DNA-templatedGO:0458939.4TNF, FOXP3, IL4, IL5, IL10
36positive regulation of transcription from RNA polymerase II promoterGO:0459449.3TNF, FOXP3, IFNG, IL4, IL10, SLC11A1
37inflammatory responseGO:0069549.2TNF, CXCR1, IL5, IL10, IL13, SLC11A1

Molecular functions related to Leishmaniasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:0051649.9LTA, TNF
2growth factor activityGO:0080839.5IL10, IL5, IL4
3cytokine activityGO:0051258.6LTA, TNF, IFNG, IL4, IL5, IL10

Products for genes affiliated with Leishmaniasis

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Leishmaniasis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet