MCID: LSH001
MIFTS: 74

Leishmaniasis malady

Rare diseases, Infectious diseases categories
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Summaries for Leishmaniasis

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8Disease Ontology, 43NIH Rare Diseases, 34MedlinePlus, 4CDC, 65Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 Leishmaniasis is a parasitic disease spread by the bite of infected sand flies. there are several different forms of leishmaniasis. the most common are cutaneous and visceral. the cutaneous type causes skin sores. the visceral type affects internal organs such as the spleen, liver, and bone marrow. people with this form usually have fever, weight loss, and an enlarged spleen and liver. leishmaniasis is found in parts of about 88 countries. most of these countries are in the tropics and subtropics. it is possible but very unlikely that you would get this disease in the united states. but you should be aware of it if you are traveling to the middle east or parts of central america, south america, asia, africa or southern europe. treatment is with medicines that contain antimony, a type of metal, or with strong antibiotics. the best way to prevent the disease is to protect yourself from sand fly bites: stay indoors from dusk to dawn, when sand flies are the most active wear long pants and long-sleeved shirts when outside use insect repellent and bed nets as needed centers for disease control and prevention

MalaCards: Leishmaniasis, also known as leishmaniasis, unspecified, is related to visceral leishmaniasis and cutaneous leishmaniasis. An important gene associated with Leishmaniasis is IFNG (interferon, gamma), and among its related pathways are Inflammatory Response Pathway and Immune response IL 23 signaling pathway. The drugs ketoconazole and itraconazole and the compounds alpha-galactosylceramide and interferon gamma have been mentioned in the context of this disorder. Affiliated tissues include skin, bone marrow and bone, and related mouse phenotypes are craniofacial and tumorigenesis.

Disease Ontology:8 A parasitic protozoa infectious disease that involves infection caused by protozoan parasite of the genus leishmania, which is transmitted by the bite of sand fly (subfamily phlebotominae).

NIH Rare Diseases:43 Leishmaniasis is a parasitic disease spread by the bite of infected sand flies. there are several different forms of leishmaniasis. the most common are cutaneous and visceral. the cutaneous type causes skin sores. the visceral type affects internal organs such as the spleen, liver and bone marrow. people with this form usually have fever, weight loss, and an enlarged spleen and liver. visceral disease can be deadly without proper treatment. leishmaniasis is found in parts of the middle east, central america, south american, asia, africa, and southern europe. most of these countries are in the tropics and subtropics. it is possible but very unlikely to get this disease in the united states. last updated: 7/6/2011

CDC:4 Leishmaniasis is a parasitic disease that is found in parts of the tropics, subtropics, and southern Europe. It is classified as a Neglected Tropical Disease (NTD). Leishmaniasis is caused by infection with Leishmania parasites, which are spread by the bite of phlebotomine sand flies. There are several different forms of leishmaniasis in people. The most common forms are cutaneous leishmaniasis, which causes skin sores, and visceral leishmaniasis, which affects several internal organs (usually spleen, liver, and bone marrow).

Wikipedia:65 Leishmaniasis (/?li??m??na??s?s/) or leishmaniosis (/li???me?n??o?s?s/ or /li???m more...

Description from OMIM:47 608207

Aliases & Classifications for Leishmaniasis

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43NIH Rare Diseases, 8Disease Ontology, 10DISEASES, 45Novoseek, 49Orphanet, 47OMIM, 34MedlinePlus, 62UMLS, 40NCIt, 58SNOMED-CT, 27ICD9CM, 35MeSH, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet, 36MESH via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases


Characteristics (Orphanet epidemiological data):

49
leishmaniasis:
Inheritance: Sporadic; Prevalence: 1-9/1000000; Age of onset: Variable


Aliases & Descriptions:

leishmaniasis 8 43 10 45 49 47 34 62
leishmaniasis, unspecified 8
leishmaniasis, cutaneous 62
leishmaniasis, visceral 62
cutaneous leishmaniasis 43
visceral leishmaniasis 43
leishmaniasis nos 8
kala-azar 43


External Ids:

Disease Ontology8 DOID:9065
NCIt40 C34767
ICD9CM27 085, 085.9
MeSH35 D007896
ICD10 via Orphanet26 B55.0, B55.1, B55.2 B55.9, more
SNOMED-CT via Orphanet59 80612004
UMLS via Orphanet63 C0023281
OMIM47 608207
MESH via Orphanet36 D007896

Related Diseases for Leishmaniasis

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17GeneCards, 18GeneDecks
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Diseases related to Leishmaniasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 220)
idRelated DiseaseScoreTop Affiliating Genes
1visceral leishmaniasis32.1PKD2L1
2cutaneous leishmaniasis32.0IFNG, IL10
3mucocutaneous leishmaniasis31.6PKD2L1
4leprosy30.8SLC11A1
5malaria30.5TNF, MT-CYB, IFNGR1, IFNG, IL10, SLC11A1
6strongyloidiasis30.5IL5
7tuberculoid leprosy30.4IFNG, IL10
8uveitis30.3IL4, IL10, IFNG, CXCR1, LTA, TNF
9arthritis30.2IL4, IL13, CXCR1, IL10, FOXP3, IFNG
10lepromatous leprosy30.2IL4, LTA, IL10, IFNG
11rheumatoid arthritis30.1IL4, IL10, SLC11A1, IFNG, LTA, FOXP3
12psoriatic arthritis30.1TNF, IL13
13dermatitis30.1IFNG, IL13, IL5, FOXP3, IL4
14chronic granulomatous disease30.1MT-CYB, IFNG
15tuberculosis30.0IFNG, SLC11A1, TNF, HSPA4, CXCR1, IFNGR1
16lymphopenia30.0IL10, IFNG, FOXP3, IL4
17connective tissue disease30.0FOXP3, IL4, IL10, TNF
18filariasis29.9IL13, IL5
19aspergillosis29.9MT-CYB, IFNG
20sarcoidosis29.9SLC11A1, LTA, IL13, IFNG, IFNGR1, HSPA4
21pulmonary sarcoidosis29.9IFNG, TNF, LTA
22leukemia29.8HSPA4, TNF, FOXP3, CXCR1, IFNG, IL4
23sepsis29.8CXCR1, TNF, IL10, LTA
24schistosomiasis29.7IFNG, IL4, IL5, IL10, IL13, IFNGR1
25systemic lupus erythematosus29.7IFNGR1, TNF, IL4, IL10, LTA, IFNG
26pulmonary tuberculosis29.7CXCR1, IL4, IFNGR1, SLC11A1, IL10, IFNG
27psoriasis29.6IL10, LTA, IL5, IL4, IFNG, CXCR1
28trypanosomiasis10.5
29chagas disease10.5
30immune-complex glomerulonephritis10.4
31acquired immunodeficiency syndrome10.3
32erysipeloid10.3
33hemophagocytic lymphohistiocytosis10.3
34leptospirosis10.3
35indeterminate leprosy10.3
36felty's syndrome10.3
37disseminated intravascular coagulation10.3
38syphilis10.3
39toxoplasmosis10.3
40anterior uveitis10.3
41leukopenia10.3
42splenomegaly10.2
43hiv-110.2
44sleeping sickness10.2
45pancytopenia10.2
46blindness10.2
47hepatitis10.2
48periapical granuloma10.1IL4
49eosinophilic fasciitis10.1IL5
50intraocular lymphoma10.1IL10

Graphical network of the top 20 diseases related to Leishmaniasis:



Diseases related to leishmaniasis

Symptoms for Leishmaniasis

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47OMIM
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Clinical features from OMIM:

608207

Drugs & Therapeutics for Leishmaniasis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Leishmaniasis

Search NIH Clinical Center for Leishmaniasis

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Leishmaniasis

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Anatomical Context for Leishmaniasis

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33MalaCards
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MalaCards organs/tissues related to Leishmaniasis:

33
Skin, Bone marrow, Bone, Liver, Spleen, T cells, Testes, Monocytes, Kidney, Whole blood, B cells, Pancreas, Lymph node, Salivary gland, Brain, Spinal cord, Myeloid, Tonsil, Smooth muscle, Prostate, Colon, Endothelial

Animal Models for Leishmaniasis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Leishmaniasis:

37 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053829.1IL10, IL4, IFNG, FOXP3, TNF
2MP:00020069.1TNF, IFNGR1, IFNG, IL5, IL10, SLC11A1
3MP:00030128.9TNF, FOXP3, IFNG, IL4, IL10, IL13
4MP:00053908.8TNF, IFNGR1, IFNG, IL4, IL10, LTA
5MP:00053918.8TNF, MPI, FOXP3, IFNG, IL4, IL10
6MP:00107718.7TNF, FOXP3, IFNGR1, IFNG, IL4, IL10
7MP:00053888.6TNF, FOXP3, IFNG, IL4, IL5, IL10
8MP:00053708.5TNF, FOXP3, IFNGR1, IFNG, IL4, IL5
9MP:00053808.5TNF, MPI, IFNGR1, IFNG, IL5, IL10
10MP:00053858.4TNF, MPI, FOXP3, IFNGR1, IFNG, IL10
11MP:00053818.3SLC11A1, TNF, FOXP3, IFNGR1, IFNG, IL4
12MP:00053788.2TNF, MPI, FOXP3, IFNG, IL4, IL5
13MP:00053768.1TNF, FOXP3, IFNGR1, IFNG, IL4, IL5
14MP:00053798.0TNF, HSPA4, FOXP3, IFNGR1, IFNG, IL4
15MP:00053878.0TNF, FOXP3, IFNGR1, IFNG, IL4, IL5
16MP:00053867.9TNF, HSPA4, PGD, FOXP3, IFNGR1, IFNG
17MP:00053847.9TNF, HSPA4, MPI, FOXP3, IFNGR1, IFNG
18MP:00053897.8TNF, HSPA4, PGD, FOXP3, IFNGR1, IFNG
19MP:00053977.7IFNGR1, FOXP3, MPI, TNF, IFNG, IL4
20MP:00036317.7TNF, HSPA4, MPI, IFNGR1, IFNG, IL4
21MP:00107687.4FOXP3, MPI, HSPA4, TNF, IFNGR1, IFNG

Publications for Leishmaniasis

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52PubMed
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Articles related to Leishmaniasis:

(show top 50)    (show all 1584)
idTitleAuthorsYear
1
Treatment-based strategy for the management of post-kala-azar dermal leishmaniasis patients in the Sudan. (23690794)
2013
2
Experimental infection of dogs with Leishmania and saliva as a model to study Canine Visceral Leishmaniasis. (23577121)
2013
3
Molecular diagnosis of leishmaniasis at the subgenus and species level. (24189975)
2013
4
Atypical presentation of cutaneous leishmaniasis in a renal transplant recipient successfully treated with allopurinol and fluconazole. (22750767)
2013
5
Pentalinon andrieuxii Root Extract is Effective in the Topical Treatment of Cutaneous Leishmaniasis Caused by Leishmania mexicana. (24347110)
2013
6
Clinical findings and management of imported cutaneous leishmaniasis: report of 14 cases from Austria. (23522841)
2013
7
Ecology of leishmaniasis in the South of France. 22. Reliability and representativeness of 12 Phlebotomus ariasi, P. perniciosus and Sergentomyia minuta (Diptera: Psychodidae) sampling stations in Vallespir (eastern French Pyrenees region). (24112589)
2013
8
What is responsible for a large and unusual outbreak of leishmaniasis in Madrid? (24275160)
2013
9
Role of fine-needle aspiration cytology in the prompt diagnosis of recurrence of visceral leishmaniasis presented as isolated cervical leishmanial lymphadenopathy. (21671412)
2013
10
LeishmaniaA braziliensis-Reactive T Cells Are Down-Regulated in Long-Term Cured Cutaneous Leishmaniasis, but the Renewal Capacity of T Effector Memory Compartments Is Preserved. (24303052)
2013
11
Association of interleukin-18 gene variants with susceptibility to visceral leishmaniasis in Iranian population. (23269628)
2013
12
Effect of 3-alkylpyridine marine alkaloid analogues in Leishmania species related to American cutaneous leishmaniasis. (22882996)
2012
13
Factors associated with asymptomatic infection in family members and neighbors of patients with visceral leishmaniasis. (23288063)
2012
14
Killed but metabolically active Leishmania infantum as a novel whole-cell vaccine for visceral leishmaniasis. (22323556)
2012
15
Prevalence, features and risk factors for malaria co-infections amongst visceral leishmaniasis patients from Amudat Hospital, Uganda. (22506087)
2012
16
Comparative study of rK39 Leishmania antigen for serodiagnosis of visceral leishmaniasis: systematic review with meta-analysis. (22303488)
2012
17
Recent advances in development of amphotericin B formulations for the treatment of visceral leishmaniasis. (23147810)
2012
18
Resistance to visceral leishmaniasis is severely compromised in mice deficient of bradykinin B2-receptors. (23151408)
2012
19
Distinct pattern of immunophenotypic features of innate and adaptive immunity as a putative signature of clinical and laboratorial status of patients with localized cutaneous leishmaniasis. (22823491)
2012
20
The knowledge, attitude, and prevention practices of students regarding cutaneous leishmaniasis in the hyperendemic region of the Shahid Babaie Airbase. (22022818)
2012
21
Asymptomatic carriage of Leishmania in family members of patients with visceral leishmaniasis in Central Tunisia. (22154335)
2012
22
The economic value of a visceral leishmaniasis vaccine in Bihar state, India. (22403311)
2012
23
Latency time in cutaneous leishmaniasis. (21505401)
2011
24
IL-27 and IL-21 are associated with T cell IL-10 responses in human visceral leishmaniasis. (21357266)
2011
25
PKCI' regulates IL-12p40/p70 production by macrophages and dendritic cells, driving a type 1 healer phenotype in cutaneous leishmaniasis. (21287553)
2011
26
First report on natural infection of Phlebotomus sergenti with Leishmania promastigotes in the cutaneous leishmaniasis focus in southeastern Tunisia. (21976566)
2011
27
Case report: Acute renal injury as a result of liposomal amphotericin B treatment in sodium stibogluconate unresponsive visceral leishmaniasis. (22144439)
2011
28
Canine visceral leishmaniasis: study of methods for the detection of IgG in serum and eluate samples. (21748226)
2010
29
Sand fly Surveillance within an Emerging Epidemic Focus of Cutaneous Leishmaniasis in Southeastern Iran. (22808384)
2010
30
Treatment of acute cutaneous leishmaniasis with intralesional injection of meglumine antimoniate: comparison of conventional technique with mesotherapy gun. (20883265)
2010
31
CD8+ T cells as a source of IFN-I^ production in human cutaneous leishmaniasis. (20967288)
2010
32
Comparison of three methods for diagnosis of cutaneous leishmaniasis. (22347259)
2010
33
Study of sand fly fauna in an endemic area of American cutaneous leishmaniasis and canine visceral leishmaniasis in the municipality of EspA-rito Santo do Pinhal, SALo Paulo, Brazil. (20428683)
2010
34
Immunophenotypic pattern and cytokine profiles of dry type cutaneous leishmaniasis. (19566354)
2009
35
IFN-beta impairs superoxide-dependent parasite killing in human macrophages: evidence for a deleterious role of SOD1 in cutaneous leishmaniasis. (19201909)
2009
36
Anti-iL-10 mAb protection against experimental visceral leishmaniasis via induction of Th1 cytokines and nitric oxide. (19634715)
2009
37
Relapsing cutaneous leishmaniasis in a patient with ankylosing spondylitis treated with infliximab. (19556566)
2009
38
Pregnancy enhances the innate immune response in experimental cutaneous leishmaniasis through hormone-modulated nitric oxide production. (18347075)
2008
39
Treatment of mucosal leishmaniasis in Latin America: systematic review. (17690398)
2007
40
Report of an atypical case of leishmaniasis presented as acute tonsillitis in an immunocompetent patient. (16308231)
2005
41
Adenosine deaminase activity in sera of patients with visceral leishmaniasis in Nepal. (15970028)
2005
42
Mucocutaneous leishmaniasis: an imported infection among travellers to central and South America. (15472268)
2004
43
Recent advances in research and control of malaria, leishmaniasis, trypanosomiasis and schistosomiasis. (15748049)
2003
44
Rhabdomyolysis induced by pentamidine (Pentacarinat) during treatment of cutaneous leishmaniasis: 2 cases]. (11937930)
2002
45
Chronic dacryocystitis in American mucocutaneous leishmaniasis. (11206745)
2001
46
In situ expression of interleukin-10 and interleukin-12 in active human cutaneous leishmaniasis. (8880134)
1996
47
Polymorphism in tumor necrosis factor genes associated with mucocutaneous leishmaniasis. (7595196)
1995
48
CD23 and IgE expression during the human immune response to cutaneous leishmaniasis: possible role in monocyte activation. (8008965)
1994
49
Treatment of visceral leishmaniasis with pentavalent antimony and interferon gamma. (2104665)
1990
50
Mucocutaneous leishmaniasis--an unsolved clinical problem. (841692)
1977

Variations for Leishmaniasis

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Expression for genes affiliated with Leishmaniasis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Leishmaniasis

Search GEO for disease gene expression data for Leishmaniasis.

Pathways for genes affiliated with Leishmaniasis

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50PathCards, 38NCBI BioSystems Database, 60Thomson Reuters, 53QIAGEN, 30KEGG, 54R&D Systems, 5Cell Signaling Technology
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Pathways related to Leishmaniasis according to GeneCards/GeneDecks:

(show all 41)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8IFNG, IL4, IL5
2
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.8IL10, IFNG, TNF
39.8TNF, IFNG, IL10
49.8TNF, IFNG, IL10
59.8IL10, IFNG, TNF
69.8IL4, IFNG, TNF
79.7IL13, IL5, IL4
89.7TNF, IL10, IL13
9
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
9.7LTA, IL4, TNF
109.7IL5, IL4, TNF
119.6IL10, IL4, FOXP3
12
Show member pathways
Immune response MIF in innate immunity response60
9.6TNF, IFNGR1, IFNG
139.6TNF, IFNGR1, IFNG
149.6TNF, IFNGR1, IFNG
15
Show member pathways
IL2 signaling events mediated by STAT538
9.6LTA, IL4, FOXP3
169.5IFNG, IL4, IL5, IL13
179.5IL4, IL5, IL10, LTA
18
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells38
9.4TNF, IL4, IL5, IL13
19
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
9.4IL10, IFNG, IFNGR1, TNF
209.4IL10, IFNG, IFNGR1, TNF
21
Show member pathways
9.4IL4, IFNG, IFNGR1, TNF
22
Show member pathways
Immune response CD16 signaling in NK cells60
9.4TNF, IFNGR1, IFNG, IL4
23
Show member pathways
9.4IL10, IFNG, FOXP3, TNF
24
Show member pathways
9.3TNF, IFNGR1, IFNG, LTA
25
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
9.3TNF, IFNG, IL4, IL5, IL10
26
Show member pathways
IL27-mediated signaling events38
9.1TNF, IFNGR1, IFNG, IL10, LTA
27
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.1TNF, IFNGR1, IFNG, IL4, LTA
28
Show member pathways
Calcium signaling in the CD4+ TCR pathway38
9.1TNF, FOXP3, IFNG, IL4, IL5
299.0IFNG, IL4, IL5, IL10, IL13, LTA
309.0TNF, IFNG, IL4, IL5, IL10, IL13
31
Show member pathways
8.9TNF, IL4, IL5, IL10, IL13, LTA
32
Show member pathways
8.9TNF, IL4, IL5, IL10, IL13, LTA
33
Show member pathways
8.9TNF, IL4, IL5, IL10, IL13, LTA
34
Show member pathways
Type III interferon signaling38
8.9IFNGR1, IFNG, IL4, IL5, IL10, IL13
35
Show member pathways
8.9TNF, IFNGR1, IFNG, IL4, IL13, LTA
36
Show member pathways
8.8TNF, HSPA4, IFNGR1, IFNG, LTA
378.7LTA, TNF, IFNG, IL4, IL5, IL10
38
Show member pathways
8.4TNF, IFNGR1, IFNG, IL4, IL5, IL10
39
Show member pathways
8.2TNF, FOXP3, IFNGR1, IFNG, IL4, IL5
40
Show member pathways
7.9TNF, CXCR1, IFNGR1, IFNG, IL4, IL5
41
Show member pathways
7.8TNF, HSPA4, IFNGR1, IFNG, IL4, IL5

Compounds for genes affiliated with Leishmaniasis

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Sources:
45Novoseek, 11DrugBank, 51PharmGKB, 29IUPHAR, 61Tocris Bioscience, 3BitterDB, 24HMDB
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Compounds related to Leishmaniasis according to GeneCards/GeneDecks:

(show top 50)    (show all 150)
idCompoundScoreTop Affiliating Genes
1alpha-galactosylceramide4510.0IL4, IFNG, IL10, IL13
2interferon gamma459.9IFNG, TNF, IL4, IL10
3mip 1alpha459.8IL4, IL13, TNF, IL10
4praziquantel45 1110.8IL4, IL5, IL10, IL13
5glatiramer acetate45 1110.7IL13, IL10, IL5, IL4, IFNG
6amphotericin b459.7IL13, IFNG, IL4, IL5
7okt3459.7LTA, IL10, IL4, IFNG, TNF
8indoleamine459.7IFNG, TNF, IL10, IL13
9polyinosinic-polycytidylic acid459.6IL4, IL5, IL10, IFNG, TNF
10infliximab45 51 1111.6IL10, IL4, LTA, IFNG, TNF
11montelukast45 51 29 1112.6IL10, IL13, IL5, IL4
12budesonide45 51 1111.6TNF, IL13, IL5, IL4, IFNG
13fluticasone propionate45 51 61 1112.6IFNG, IL13, IL5, IL4, TNF
14neopterin459.6TNF, IFNG, LTA, IL10, IL4
15allergens459.6IFNG, IL10, IL4, IL5, IL13
16con a459.6IFNG, IL4, IL5, IL10
17imiquimod45 61 29 1112.5TNF, IFNG, IL10, IL5
18il-12459.5IL5, IL4, IL13, TNF, IL10, IFNG
19gm-csf45 2910.4IL5, IFNG, TNF, IL4, IL10, IL13
20pentoxifylline45 1110.4TNF, IL13, IFNG, IL10, IL4, LTA
21polymyxin b459.4TNF, IFNG, IL10, IL4
22rolipram45 61 2911.4IL13, TNF, IFNG, IL4, IL5, IL10
23thalidomide45 51 61 1112.4IL13, IL5, IFNG, TNF, IL10
24ivig459.4LTA, IL10, IL5, IFNG, TNF, IL4
25ccl345 2910.4CXCR1, IFNG, IL10, IL13, TNF
26hydrocortisone45 3 61 1112.4IL13, IL10, IL5, IL4, TNF, IFNG
27prednisolone45 29 1111.3IL10, IFNG, IL5, LTA, TNF, IL13
28rantes459.3IFNG, CXCR1, IL5, IL10, IL13, IL4
2915-deoxy-delta-12,14-prostaglandin j2459.3IFNG, TNF, HSPA4, IL4, IL10
30tacrolimus45 51 1111.3IL13, TNF, IFNG, IL4, IL5, IL10
31calcitriol45 61 24 1112.3IL10, IL4, TNF, IFNG, LTA, IL13
32il 10459.2IL5, IL10, IL13, LTA, TNF, IFNG
33ionomycin459.2IL10, IL13, LTA, IFNG, IL5, IL4
34endotoxin459.1CXCR1, TNF, IFNG, LTA, IL10, IL13
35thyroxine45 2410.1LTA, IL13, IL10, IL4, HSPA4, IL5
36tarc459.0IL4, IL5, IL10, IL13, TNF, IFNG
37groalpha459.0TNF, CXCR1, IL10, IL13
38fmlp458.9CXCR1, MT-CYB, IL5, IL13, LTA, TNF
39sb 20358045 619.9HSPA4, TNF, IL13, IFNG, IL4, IL5
40indomethacin45 29 61 1111.8HSPA4, IFNG, LTA, IL13, TNF, IL4
41thymidine45 249.8IL13, IFNG, IL10, IL5, TNF, IL4
42cyclosporin a45 29 6110.7TNF, LTA, IL13, IL10, IL5, IFNG
43pge2458.7FOXP3, IFNG, IL5, IL10, IL13, LTA
44herbimycin a45 619.6IL5, IFNG, CXCR1, HSPA4, TNF, LTA
45actinomycin d458.6IL4, CXCR1, HSPA4, TNF, LTA, IL13
46aspartate458.4HSPA4, MT-CYB, PGD, IL10, IL13, SLC11A1
47dexamethasone45 51 29 1111.2IL10, IL4, IFNG, CXCR1, HSPA4, TNF
48vegf458.1LTA, IL10, CXCR1, HSPA4, TNF, IL4
49nitric oxide45 24 119.9LTA, SLC11A1, IL13, TNF, HSPA4, PGD
50cycloheximide457.3LTA, TNF, HSPA4, LMLN, CXCR1, IL5

GO Terms for genes affiliated with Leishmaniasis

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16Gene Ontology
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Cellular components related to Leishmaniasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.5IL13, IL4, IFNG, TNF
2extracellular spaceGO:0056158.4LTA, TNF, IFNG, IL4, IL5, IL10

Biological processes related to Leishmaniasis according to GeneCards/GeneDecks:

(show all 37)
idNameGO IDScoreTop Affiliating Genes
1regulation of isotype switchingGO:04519110.4IL4, IL10
2type 2 immune responseGO:04209210.4IL10, IL4
3positive regulation of vitamin D biosynthetic processGO:06055710.4TNF, IFNG
4positive regulation of calcidiol 1-monooxygenase activityGO:06055910.3TNF, IFNG
5positive regulation of isotype switching to IgG isotypesGO:04830410.3IFNG, IL4
6receptor biosynthetic processGO:03280010.3TNF, IL10
7regulation of proton transportGO:01015510.3IL4, IL13
8positive regulation of chronic inflammatory response to antigenic stimulusGO:00287610.3TNF, LTA
9positive regulation of MHC class II biosynthetic processGO:04534810.3IL10, IL4, IFNG
10negative regulation of nitric oxide biosynthetic processGO:04501910.2IL10, IL4
11negative regulation of cytokine secretion involved in immune responseGO:00274010.2TNF, IL10
12defense response to protozoanGO:04283210.2SLC11A1, IL4, IFNG
13positive regulation of podosome assemblyGO:07180310.2TNF, IL5
14negative regulation of chronic inflammatory responseGO:00267710.2FOXP3, IL4
15positive regulation of chemokine biosynthetic processGO:04508010.2TNF, IFNG, IL4
16positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.1TNF, LTA
17protein import into nucleus, translocationGO:00006010.1SLC11A1, IFNG, TNF
18positive regulation of membrane protein ectodomain proteolysisGO:05104410.1IFNG, TNF
19positive regulation of B cell proliferationGO:03089010.1IL13, IL5, IL4
20positive regulation of immunoglobulin productionGO:00263910.0IL13, FOXP3
21positive regulation of interferon-gamma productionGO:03272910.0TNF, SLC11A1, LTA
22defense response to bacteriumGO:04274210.0IFNG, IL10, SLC11A1
23humoral immune responseGO:00695910.0LTA, IFNG, TNF
24regulation of interferon-gamma-mediated signaling pathwayGO:06033410.0IFNG, IFNGR1
25positive regulation of cytokine secretionGO:05071510.0IL10, TNF
26negative regulation of interleukin-6 productionGO:03271510.0IL10, FOXP3, TNF
27positive regulation of cytokine productionGO:0018199.9SLC11A1, TNF
28negative regulation of growth of symbiont in hostGO:0441309.9LTA, IL10, IFNG, TNF
29positive regulation of osteoclast differentiationGO:0456729.9TNF, IFNG
30positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.9TNF, IL4, IL5, IL10
31response to lipopolysaccharideGO:0324969.8IL13, SLC11A1, LTA
32response to drugGO:0424939.7TNF, IFNG, IL4, IL10, LTA
33response to virusGO:0096159.6TNF, FOXP3, IFNGR1, IFNG
34negative regulation of interferon-gamma productionGO:0326899.6IL10, FOXP3
35positive regulation of transcription, DNA-templatedGO:0458939.4TNF, FOXP3, IL4, IL5, IL10
36positive regulation of transcription from RNA polymerase II promoterGO:0459449.3TNF, FOXP3, IFNG, IL4, IL10, SLC11A1
37inflammatory responseGO:0069549.2TNF, CXCR1, IL5, IL10, IL13, SLC11A1

Molecular functions related to Leishmaniasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:0051649.9LTA, TNF
2growth factor activityGO:0080839.5IL10, IL5, IL4
3cytokine activityGO:0051258.6LTA, TNF, IFNG, IL4, IL5, IL10

Products for genes affiliated with Leishmaniasis

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Sources for Leishmaniasis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet