MCID: LSH001
MIFTS: 65

Leishmaniasis malady

Infectious category

Summaries for Leishmaniasis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 34MedlinePlus, 3CDC, 64Wikipedia, 47OMIM, 33MalaCards
See all sources

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MedlinePlus:34 Leishmaniasis is a parasitic disease spread by the bite of infected sand flies. there are several different forms of leishmaniasis. the most common are cutaneous and visceral. the cutaneous type causes skin sores. the visceral type affects internal organs such as the spleen, liver, and bone marrow. people with this form usually have fever, weight loss, and an enlarged spleen and liver. leishmaniasis is found in parts of about 88 countries. most of these countries are in the tropics and subtropics. it is possible but very unlikely that you would get this disease in the united states. but you should be aware of it if you are traveling to the middle east or parts of central america, south america, asia, africa or southern europe. treatment is with medicines that contain antimony, a type of metal, or with strong antibiotics. the best way to prevent the disease is to protect yourself from sand fly bites: stay indoors from dusk to dawn, when sand flies are the most active wear long pants and long-sleeved shirts when outside use insect repellent and bed nets as needed centers for disease control and prevention

MalaCards: Leishmaniasis, also known as leishmaniasis, unspecified, is related to visceral leishmaniasis and cutaneous leishmaniasis. An important gene associated with Leishmaniasis is IFNG (interferon, gamma), and among its related pathways are Allograft rejection and Cytokine Network. The drugs ketoconazole and itraconazole and the compounds nitric oxide and vegf have been mentioned in the context of this disorder. Related mouse phenotypes are hematopoietic system and digestive/alimentary.

Disease Ontology:8 A parasitic protozoa infectious disease that involves infection caused by protozoan parasite of the genus leishmania, which is transmitted by the bite of sand fly (subfamily phlebotominae).

NIH Rare Diseases:43 Leishmaniasis is a parasitic disease spread by the bite of infected sand flies. there are several different forms of leishmaniasis. the most common are cutaneous and visceral. the cutaneous type causes skin sores. the visceral type affects internal organs such as the spleen, liver and bone marrow. people with this form usually have fever, weight loss, and an enlarged spleen and liver. visceral disease can be deadly without proper treatment. leishmaniasis is found in parts of the middle east, central america, south american, asia, africa, and southern europe. most of these countries are in the tropics and subtropics. it is possible but very unlikely to get this disease in the united states. last updated: 7/6/2011

CDC:3 Leishmaniasis is a parasitic disease that is found in parts of the tropics, subtropics, and southern Europe. It is classified as a Neglected Tropical Disease (NTD). Leishmaniasis is caused by infection with Leishmania parasites, which are spread by the bite of phlebotomine sand flies. There are several different forms of leishmaniasis in people. The most common forms are cutaneous leishmaniasis, which causes skin sores, and visceral leishmaniasis, which affects several internal organs (usually spleen, liver, and bone marrow).

Wikipedia:64 Leishmaniasis (/ˌliːʃməˈnaɪəsɪs/) or leishmaniosis (/liːʃˌmeɪnɪˈəʊsɪs/ or... more...

Description from OMIM:47 608207

Aliases & Classifications for Leishmaniasis

Sources:
43NIH Rare Diseases, 8Disease Ontology, 10DISEASES, 45Novoseek, 49Orphanet, 47OMIM, 34MedlinePlus, 61UMLS, 27ICD9CM, 35MeSH, 40NCIt, 57SNOMED-CT, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 36MESH via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Characteristics (Orphanet epidemiological data):

49
leishmaniasis:
Inheritance: Sporadic; Prevalence: 1-9/1000000; Age of onset: Variable


Aliases & Descriptions:

leishmaniasis 8 43 10 45 49 47 34 61
leishmaniasis, unspecified 8
leishmaniasis, cutaneous 61
leishmaniasis, visceral 61
cutaneous leishmaniasis 43
visceral leishmaniasis 43
leishmaniasis nos 8
kala-azar 43


External Ids:

Disease Ontology8 DOID:9065
ICD9CM27 085, 085.9
MeSH35 D007896
NCIt40 C34767
ICD10 via Orphanet26 B55
SNOMED-CT via Orphanet58 80612004
UMLS via Orphanet62 C0023281
OMIM47 608207
MESH via Orphanet36 D007896

Related Diseases for Leishmaniasis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Leishmaniasis family:

visceral leishmaniasis

Diseases related to Leishmaniasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 247)
idRelated DiseaseScoreTop Affiliating Genes
1visceral leishmaniasis31.9PKD2L1
2cutaneous leishmaniasis31.9IL10, IFNG
3mucocutaneous leishmaniasis31.4PKD2L1
4chagas disease30.7MT-CYB
5arthritis30.5LTA, IFNG, TNF, SLC11A1, FOXP3, IL10
6uveitis30.3TNF, IFNG, LTA, CXCR1, IL4, IL10
7tuberculosis30.2IL10, CXCR1, MDH2, TNF, IFNGR1, IFNG
8tuberculoid leprosy30.2IL10, IFNG
9lepromatous leprosy30.1IFNG, LTA, IL4, IL10
10hepatitis c30.0IFNG, TNF, IL10, IL4
11psoriatic arthritis30.0TNF
12chronic granulomatous disease30.0MT-CYB
13ankylosing spondylitis30.0TNF
14pulmonary tuberculosis29.8IFNGR1, IFNG, SLC11A1, IL4, IL10, CXCR1
15systemic lupus erythematosus29.8IFNGR1, LTA, IL10, IFNG, IL4, TNF
16aspergillosis29.8IFNG, MT-CYB
17hepatitis b29.8IFNG, HSPA4
18acute leukemia29.8CXCR1, CSN2
19onchocerciasis29.8IL5
20pulmonary sarcoidosis29.8IFNG, TNF, LTA
21nephritis29.8LTA
22sepsis29.8IL10, CXCR1, TNF, LTA
23tonsillitis29.8LTA
24trypanosomiasis10.5
25immune-complex glomerulonephritis10.4
26hemophagocytic lymphohistiocytosis10.3
27acquired immunodeficiency syndrome10.3
28erysipeloid10.3
29splenomegaly10.2
30indeterminate leprosy10.2
31strongyloidiasis10.2
32felty's syndrome10.2
33leptospirosis10.2
34tropical sprue10.2
35syphilis10.2
36toxoplasmosis10.2
37anterior uveitis10.2
38leukopenia10.2
39sleeping sickness10.2
40pancytopenia10.2
41kala-azar 210.2
42paronychia10.1
43granulomatous dermatitis10.1
44borderline leprosy10.1
45autoimmune hepatitis10.1
46malignant histiocytosis10.1
47sporotrichosis10.1
48hepatitis a10.1
49yaws10.1
50hepatitis e10.0

Graphical network of the top 20 diseases related to Leishmaniasis:



Diseases related to leishmaniasis

Clinical Features for Leishmaniasis

Sources:
47OMIM
See all sources

Clinical features from OMIM:

608207

Drugs & Therapeutics for Leishmaniasis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Leishmaniasis

Drug clinical trials:

Search ClinicalTrials for Leishmaniasis

Search NIH Clinical Center for Leishmaniasis

Search CenterWatch for Leishmaniasis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Leishmaniasis

Anatomical Context for Leishmaniasis

Animal Models for Leishmaniasis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Leishmaniasis

Sources:
51PubMed
See all sources

Articles related to Leishmaniasis:

(show top 50)    (show all 1601)
idTitleAuthorsYear
1
Proteomics advances in the study of leishmania parasites and leishmaniasis. (24264252)
2014
2
Liposomal amphotericin B for complicated visceral leishmaniasis (kala-azar) in eastern Sudan: how effective is treatment for this neglected disease? (24433217)
2014
3
Performance of an indigenous I^-mercaptoethanol-modified antigen in comparison with a commercial reference in direct agglutination test for detection of canine visceral leishmaniasis. (24143006)
2014
4
Visceral leishmaniasis (kalazar) migrating West: A new autochthonous case from sub-Himalayas. (24399404)
2014
5
Molecular characterization of leishmania infection from naturally infected sand flies caught in a focus of cutaneous leishmaniasis (eastern iran). (24409437)
2013
6
Visceral leishmaniasis with associated immune dysregulation leading to lymphoma. (23707131)
2013
7
Cationic solid-lipid nanoparticles are as efficient as electroporation in DNA vaccination against visceral leishmaniasis in mice. (23710803)
2013
8
Involvement and interactions of different immune cells and their cytokines in human visceral leishmaniasis. (23559342)
2013
9
Chronic exposure to arsenic in drinking water can lead to resistance to antimonial drugs in a mouse model of visceral leishmaniasis. (24167266)
2013
10
CD8(+) granzyme B(+)-mediated tissue injury vs. CD4(+)IFNI^(+)-mediated parasite killing in human cutaneous leishmaniasis. (23321919)
2013
11
War diseases revealed by the social media: massive leishmaniasis outbreak in the Syrian Spring. (23587258)
2013
12
Detection and molecular typing of Leishmania tropica from Phlebotomus sergenti and lesions of cutaneous leishmaniasis in an emerging focus of Morocco. (23890256)
2013
13
The potential economic value of a cutaneous leishmaniasis vaccine in seven endemic countries in the Americas. (23176979)
2013
14
Post-Kala-azar dermal leishmaniasis due to Leishmania donovani in Europe--case report. (24261735)
2013
15
Clinical and epidemiologic profile of cutaneous leishmaniasis in Colombian children: considerations for local treatment. (23798581)
2013
16
Influence of the nutritional status in the clinical and therapeutical evolution in adults and elderly with American Tegumentary Leishmaniasis. (23792228)
2013
17
Microalbuminuria and glomerular filtration rate in paediatric visceral leishmaniasis. (23865054)
2013
18
Effect of 3-alkylpyridine marine alkaloid analogues in Leishmania species related to American cutaneous leishmaniasis. (22882996)
2012
19
Resistance to visceral leishmaniasis is severely compromised in mice deficient of bradykinin B2-receptors. (23151408)
2012
20
Sialoglycosylation of RBC in visceral leishmaniasis leads to enhanced oxidative stress, calpain-induced fragmentation of spectrin and hemolysis. (22860118)
2012
21
American visceral leishmaniasis in Chiapas, Mexico. (22232459)
2012
22
Public Knowledge about and Detection of Canine Visceral Leishmaniasis in Urban DivinA^polis, Brazil. (22991521)
2012
23
Efficacy and tolerability of oleylphosphocholine (OlPC) in a laboratory model of visceral leishmaniasis. (22782488)
2012
24
Hemophagocytic syndrome associated with visceral leishmaniasis in an immunocompetent adult-case report and review of the literature. (22080147)
2012
25
The efficacy of aerosol treatment with non-ionic surfactant vesicles containing amphotericin B in rodent models of leishmaniasis and pulmonary aspergillosis infection. (22516093)
2012
26
Constructing ecological networks: a tool to infer risk of transmission and dispersal of leishmaniasis. (22958263)
2012
27
Decrease in anti-Leishmania IgG3 and IgG1 after cutaneous leishmaniasis lesion healing is correlated with the time of clinical cure. (22742527)
2012
28
Toolkit for monitoring and evaluation of indoor residual spraying for visceral leishmaniasis control in the Indian subcontinent: application and results. (21811510)
2011
29
Central nervous system toxicity associated with liposomal amphotericin B therapy for cutaneous leishmaniasis. (21460011)
2011
30
Early activated Th-1 type and dominantly diverse natural killer T (CD3a8_CD161a8_VI+24a8>) cells in bone marrow among visceral leishmaniasis patients. (21787777)
2011
31
Serological markers of sand fly exposure to evaluate insecticidal nets against visceral leishmaniasis in India and Nepal: a cluster-randomized trial. (21931871)
2011
32
Morphometric and morphological variation between two different populations of Phlebotomus major s.l. from endemic and non-endemic foci of visceral leishmaniasis in Iran. (21635653)
2011
33
Comment on: Cutaneous and mucocutaneous leishmaniasis in Tigray, northern Ethiopia: clinical aspects and therapeutic concerns. (19836815)
2010
34
Risk factors for anthroponotic cutaneous Leishmaniasis at the household level in Kabul, Afghanistan. (20351787)
2010
35
Evaluation of localized and systemic immune responses in cutaneous leishmaniasis caused by Leishmania tropica: interleukin-8, monocyte chemotactic protein-1 and nitric oxide are major regulatory factors. (20102417)
2010
36
CXCR1 and SLC11A1 polymorphisms affect susceptibility to cutaneous leishmaniasis in Brazil: a case-control and family-based study. (20089160)
2010
37
Lupoid cutaneous leishmaniasis: a report of 16 cases. (20061750)
2010
38
Socio-economic aspects of neglected diseases: sleeping sickness and visceral leishmaniasis. (21092391)
2010
39
Identification of novel Leishmania donovani antigens that help define correlates of vaccine-mediated protection in visceral leishmaniasis. (19503834)
2009
40
Spontaneous cure of American cutaneous leishmaniasis due to Leishmania naiffi in two Dutch infantry soldiers. (20055858)
2009
41
Anti-tumor necrosis factor-alpha therapy provokes latent leishmaniasis in a patient with rheumatoid arthritis. (19429808)
2009
42
A case of mucocutaneous leishmaniasis. (15886638)
2005
43
Expression of inducible nitric oxide synthase in human cutaneous leishmaniasis. (16311916)
2005
44
Evaluation of IFN-gamma and TNF-alpha as immunological markers of clinical outcome in cutaneous leishmaniasis. (11873254)
2002
45
Cutaneous New World leishmaniasis-sporotrichosis coinfection: report of 3 cases. (10365936)
1999
46
In situ expression of interleukin-10 and interleukin-12 in active human cutaneous leishmaniasis. (8880134)
1996
47
Differential expression of chemokines in patients with localized and diffuse cutaneous American leishmaniasis. (8627035)
1996
48
Acute phase proteins and plasma lipoproteins during antimony treatment in infantile visceral leishmaniasis. (8339522)
1993
49
THE HUMAN TRYPANOSOMATIDAE. IV. CUTANEOUS AND MUCOCUTANEOUS LEISHMANIASIS. (14083450)
1963
50
Mucocutaneous leishmaniasis in Kenya, with a note on penicillin treatment. (20243886)
1947

Genetic Variations for Leishmaniasis

Expression for genes affiliated with Leishmaniasis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Leishmaniasis

Search GEO for disease gene expression data for Leishmaniasis.

Pathways for genes affiliated with Leishmaniasis

Sources:
30KEGG, 52QIAGEN, 12EMD Millipore, 38NCBI BioSystems Database, 53R&D Systems, 54Reactome
See all sources

Pathways related to Leishmaniasis according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.1IFNG, IFNGR1, TNF, HSPA4, LTA, IL4
210.9IL13, LTA, TNF, IFNG, IL10, IL5
310.9IL13, IL4, IL5, IFNG, LTA, IL10
410.9IL4, IL5, IL10, IL13, IFNG, IFNGR1
5
Hide members
10.9IL10, IL5, IL4, IL13, LTA, TNF
6
Hide members
10.9LTA, IL13, IL4, IFNGR1, TNF, IFNG
7
Hide members
10.9IL4, IL5, TNF, IL13, IFNGR1, IFNG
8
Hide members
10.8IL4, IFNG, TNF, IL10, IL5
9
Hide members
10.8LTA, TNF, IFNG, IFNGR1, IL10
10
Hide members
10.8IL5, FOXP3, TNF, IL4, IFNG
1110.8CSN2, IL4, IL5, IL13, IFNG
12
Hide members
10.8IFNG, IL4, TNF, IFNGR1, CSN2
13
Hide members
10.8HSPA4, IFNG, IFNGR1, TNF, LTA
1410.7IL4, IL5, LTA, IL10
15
Hide members
10.7FOXP3, TNF, IL10, IFNG
16
Hide members
10.7TNF, IFNGR1, IFNG, IL10
1710.7IL10, TNF, IFNGR1, IFNG
18
Hide members
10.7TNF, IFNG, IFNGR1, LTA
19
Hide members
10.7IL13, IL5, FOXP3, IFNGR1
20
Hide members
10.7IFNGR1, CXCR1, IL13, IL5
2110.7IFNG, IL4, IL5
2210.7IL10, IFNG, TNF
2310.7IL13, IL5, IL4
2410.7IL4, TNF, IL5
25
Hide members
10.7IL5, IL13, LTA
26
Hide members
10.7LTA, IL13, IL5
27
Hide members
10.7IL4, LTA, FOXP3
28
Immune response Bacterial infections in normal airways
10.7IFNGR1, IFNG, TNF

Compounds for genes affiliated with Leishmaniasis

Sources:
45Novoseek, 11DrugBank, 24HMDB, 60Tocris Bioscience, 50PharmGKB, 29IUPHAR
See all sources

Compounds related to Leishmaniasis according to GeneCards/GeneDecks:

(show top 50)    (show all 124)
idCompoundScoreTop Affiliating Genes
1nitric oxide45 11 2413.5IL13, IL10, SLC11A1, PGD, LTA, MT-CYB
2vegf4511.4CXCR1, IL5, IL4, IL10, IL13, LTA
3il 104511.4TNF, IL13, IL10, IL5, IL4, IFNG
4tarc4511.4IL10, IL5, IFNG, TNF, CXCR1, IL13
5ionomycin4511.4IL4, IL5, IL13, IFNG, TNF, LTA
6herbimycin a45 6012.4IFNG, HSPA4, TNF, LTA, CXCR1, IL4
7il-124511.3IL5, TNF, IFNG, IL10, IL4, IL13
8sb 20358045 6012.3IL13, IFNG, HSPA4, TNF, IL10, IL5
9allergens4511.3IL5, IFNG, IL10, CSN2, IL13, IL4
10dexamethasone45 50 29 1114.3IL5, CXCR1, LTA, CSN2, HSPA4, IL13
11glatiramer acetate45 1112.3IL10, IL13, IL4, IFNG, IL5
12rantes4511.2LTA, IFNG, CXCR1, TNF, IL4
13aspartate4511.2PGD, MT-CYB, HSPA4, MDH2, MPI, SLC11A1
14okt34511.2IFNG, IL4, IL10, TNF, LTA
15thyroxine45 2412.2LTA, IL13, IL5, IL4, IL10, HSPA4
16budesonide45 50 1113.2TNF, IL13, IFNG, IL4, IL5
17actinomycin d4511.2CXCR1, HSPA4, IL4, IFNG, TNF, LTA
18fluticasone propionate45 50 60 1114.2IFNG, IL4, TNF, IL13, IL5
19polyinosinic-polycytidylic acid4511.2IFNG, IL5, IL10, IL4, TNF
20infliximab45 50 1113.2IL10, LTA, TNF, IFNG, IL4
21tacrolimus45 50 1113.2IFNG, TNF, IL13, IL10, IL5, IL4
22interferon gamma4511.2IL4, IL10, IFNG, TNF
23ccl345 2912.1IFNG, CXCR1, IL10, IL13, TNF
24alpha-galactosylceramide4511.1IFNG, IL4, IL10, IL13
25neopterin4511.1IL4, LTA, TNF, IL10, IFNG
26calcitriol45 60 11 2414.1IL4, IL10, TNF, IL13, LTA, IFNG
27h2o24511.1PGD, HSPA4, MDH2, MT-CYB, LTA, IL13
28gm-csf45 2912.1TNF, IL10, IFNG
29cycloheximide4511.1LTA, MT-CYB, LMLN
30mip 1alpha4511.1IL10, IL4, TNF, IL13
3115-deoxy-delta-12,14-prostaglandin j24511.1IFNG, TNF, IL4, HSPA4, IL10
32pentoxifylline45 1112.1IL13, IL4, LTA
33praziquantel45 1112.1IL5, IL4, IL10, IL13
34cyclosporin a45 29 6013.1LTA, IFNG, FOXP3
35prednisolone45 29 1113.1LTA, IL13, IL5
36lactate4511.0TNF, IL13, PGD, LTA, MDH2, CSN2
37thalidomide45 50 60 1114.0IL13, IL10, IFNG, TNF, IL5
38indomethacin45 60 29 1114.0IL5, HSPA4
39fmlp4511.0IL13, IL5, MT-CYB
40ivig4511.0IFNG
41imiquimod45 29 60 1113.9TNF, IFNG, IL10, IL5
42montelukast45 50 29 1113.9IL4, IL5, IL10, IL13
43polymyxin b4510.9IL4, TNF, IL10, IFNG
44amphotericin b4510.9IL13
45groalpha4510.8IL10, IL13, CXCR1, TNF
46indoleamine4510.8IL13
47con a4510.7IFNG, IL5, IL4, IL10
48betaseron4510.7IL4, IL10, IFNG
49omalizumab45 1111.6IL4, IL5, IL13
50superoxide45 2411.5MT-CYB, TNF, MDH2, MPI, PGD

GO Terms for genes affiliated with Leishmaniasis

Sources:
16Gene Ontology
See all sources

Cellular components related to Leishmaniasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.7IL4, IL13, TNF, IFNG
2extracellular spaceGO:00561510.6IL4, IFNG, TNF, LTA, IL13, IL10

Biological processes related to Leishmaniasis according to GeneCards/GeneDecks:

(show all 30)
idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:00695411.2SLC11A1, TNF, CXCR1, IL13, IL10, IL5
2response to drugGO:04249311.2IL10, LTA, IFNG, TNF, IL4
3negative regulation of growth of symbiont in hostGO:04413011.1TNF, IFNG, LTA, IL10
4positive regulation of sequence-specific DNA binding transcription factor activityGO:05109111.1IL4, IL5, IL10, TNF
5positive regulation of transcription from RNA polymerase II promoterGO:04594411.1IL10, FOXP3, TNF, IFNG, SLC11A1, IL4
6positive regulation of MHC class II biosynthetic processGO:04534811.1IL4, IL10, IFNG
7response to virusGO:00961511.1FOXP3, IFNG, TNF, IFNGR1
8positive regulation of chemokine biosynthetic processGO:04508011.1IL4, TNF, IFNG
9defense response to protozoanGO:04283211.1IL4, IFNG, SLC11A1
10negative regulation of interleukin-6 productionGO:03271511.0TNF, FOXP3, IL10
11protein import into nucleus, translocationGO:00006011.0IFNG, SLC11A1, TNF
12positive regulation of B cell proliferationGO:03089011.0IL5, IL13, IL4
13positive regulation of interferon-gamma productionGO:03272911.0TNF, LTA, SLC11A1
14positive regulation of vitamin D biosynthetic processGO:06055711.0IFNG, TNF
15positive regulation of chronic inflammatory response to antigenic stimulusGO:00287610.9LTA, TNF
16humoral immune responseGO:00695910.9LTA, IFNG, TNF
17negative regulation of chronic inflammatory responseGO:00267710.9IL4, FOXP3
18regulation of isotype switchingGO:04519110.9IL4, IL10
19receptor biosynthetic processGO:03280010.9IL10, TNF
20positive regulation of calcidiol 1-monooxygenase activityGO:06055910.9IFNG, TNF
21type 2 immune responseGO:04209210.9IL10, IL4
22regulation of proton transportGO:01015510.8IL13, IL4
23negative regulation of cytokine secretion involved in immune responseGO:00274010.8IL10, TNF
24positive regulation of podosome assemblyGO:07180310.8TNF, IL5
25positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.7LTA, TNF
26positive regulation of transcription, DNA-dependentGO:04589310.7IL10, IL5, IL4, TNF, FOXP3
27positive regulation of isotype switching to IgG isotypesGO:04830410.7IL4, IFNG
28positive regulation of membrane protein ectodomain proteolysisGO:05104410.6IFNG, TNF
29positive regulation of immunoglobulin productionGO:00263910.6FOXP3, IL13
30negative regulation of nitric oxide biosynthetic processGO:04501910.3IL4, IL10

Molecular functions related to Leishmaniasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.9IL4, IL5, IL10, IL13, LTA, TNF

Products for genes affiliated with Leishmaniasis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Leishmaniasis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet