MCID: LNN001
MIFTS: 51

Lennox-Gastaut Syndrome malady

Categories: Genetic diseases, Rare diseases, Neuronal diseases

Aliases & Classifications for Lennox-Gastaut Syndrome

About this section
Sources:
11Disease Ontology, 46NIH Rare Diseases, 23GeneTests, 24Genetics Home Reference, 47NINDS, 13DISEASES, 52Orphanet, 25GTR, 12diseasecard, 48Novoseek, 66UMLS, 67UMLS via Orphanet, 29ICD10 via Orphanet, 38MESH via Orphanet
See all MalaCards sources

Aliases & Descriptions for Lennox-Gastaut Syndrome:

Name: Lennox-Gastaut Syndrome 11 46 24 47 13 52 48 66
Epileptic Encephalopathy, Lennox-Gastaut Type 23 25 12
Lennox Syndrome 11 66
Childhood Epileptic Encephalopathy with Diffuse Slow Spikes and Waves 24
 
Epileptic Encephalopathy Lennox-Gastaut Type 46
Encephalopathy of Childhood 46
Lgs 24

Characteristics:

Orphanet epidemiological data:

52
lennox-gastaut syndrome:
Inheritance: Autosomal dominant,Multigenic/multifactorial,Not applicable; Prevalence: 1-9/1000000 (Europe),1-5/10000 (Europe); Age of onset: Childhood

Classifications:



External Ids:

Disease Ontology11 DOID:0050561
Orphanet52 ORPHA2382
UMLS via Orphanet67 C0238111
ICD10 via Orphanet29 G40.4
MESH via Orphanet38 C535500

Summaries for Lennox-Gastaut Syndrome

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NINDS:47 Lennox-Gastaut syndrome is a severe form of epilepsy. Seizures usually begin before 4 years of age. Seizure types, which vary among patients, include tonic (stiffening of the body, upward deviation of the eyes, dilation of the pupils, and altered respiratory patterns), atonic (brief loss of muscle tone and consciousness, causing abrupt falls), atypical absence (staring spells), and myoclonic (sudden muscle jerks). There may be periods of frequent seizures mixed with brief, relatively seizure-free periods. Most children with Lennox-Gastaut syndrome experience some degree of impaired intellectual functioning or information processing, along with developmental delays, and behavioral disturbances. Lennox-Gastaut syndrome can be caused by brain malformations, perinatal asphyxia, severe head injury, central nervous system infection and inherited degenerative or metabolic conditions. In 30-35 percent of cases, no cause can be found.

MalaCards based summary: Lennox-Gastaut Syndrome, also known as epileptic encephalopathy, lennox-gastaut type, is related to neurodegeneration with brain iron accululation 5 and trichorhinophalangeal syndrome, type ii, and has symptoms including hemiplegia, seizures and epileptic aura. An important gene associated with Lennox-Gastaut Syndrome is SCN1A (Sodium Voltage-Gated Channel Alpha Subunit 1), and among its related pathways are Synaptic Neurotransmission Pathways: GABAergic Inhibition and Benzodiazepine Pathway, Pharmacodynamics. Affiliated tissues include brain, eye and cortex, and related mouse phenotypes are reproductive system and nervous system.

Genetics Home Reference:24 Lennox-Gastaut syndrome is a form of severe epilepsy that begins in childhood. It is characterized by multiple types of seizures and intellectual disability.

NIH Rare Diseases:46 Lennox-gastaut syndrome is a form of severe epilepsy that begins in childhood. it is characterized by multiple types of seizures and intellectual disability. this condition can be caused by brain malformations, perinatal asphyxia (lack of oxygen), severe head injury, central nervous system infection and inherited degenerative or metabolic conditions. in about one-third of cases, no cause can be found. treatment for lennox-gastaut syndrome includes anti-epileptic medications such as valproate, lamotrigine, felbamate, or topiramate. there is usually no single antiepileptic medication that will control seizures. children may improve initially, but many later show tolerance to a drug or develop uncontrollable seizures. last updated: 9/17/2013

Related Diseases for Lennox-Gastaut Syndrome

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Diseases related to Lennox-Gastaut Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 59)
idRelated DiseaseScoreTop Affiliating Genes
1neurodegeneration with brain iron accululation 511.5
2trichorhinophalangeal syndrome, type ii11.3
3encephalopathy, acute, infection-induced, 410.9
4epilepsy10.8
5encephalopathy10.7
6peripheral retinal degeneration10.6MT-ND1, POMC
7double fingernail of fifth finger10.6SCN1A, SLC2A1
8west syndrome10.5
9extratemporal epilepsy10.5POMC, TBC1D24
10status epilepticus10.4
11myoclonic astatic epilepsy10.4
12cerebritis10.4
13urethral obstruction sequence10.3SCN1A, TBC1D24
14epileptic encephalopathy, early infantile, 1510.3
15scn1a-related seizure disorders10.3
16cdkl5-related disorder10.3
17ohtahara syndrome10.3GABRA1, SCN1A, TBC1D24
18epilepsy, juvenile absence 110.3GABRA1, SCN1A
19tuberous sclerosis10.3
20hypothalamic hamartomas10.3
21epidermolysis bullosa acquisita10.3POMC, SNRPE
22mononeuritis multiplex10.3GABRA1, KCNQ2, SCN1A
23granulomatous hepatitis10.3SCN1A, SLC2A1, TBC1D24
24childhood malignant hemangiopericytoma10.3SCN1A, TBC1D24
25adolescence-adult electroclinical syndrome10.2KCNQ2, POMC, SCN1A, TBC1D24
26erb-duchenne and dejerine-klumpke palsies10.1DNM1, KCNQ2, SCN1A
27angelman syndrome10.1
28common variable immunodeficiency10.1
29hepatitis10.1
30hypospadias10.1
31encephalomalacia10.1
32astrocytoma10.1
33acute disseminated encephalomyelitis10.1
34neuronitis10.1
35measles10.1
36tyrosinemia10.1
37intracranial hypertension10.1
38polymicrogyria10.1
39pachygyria10.1
40cutis verticis gyrata10.1
41hemimegalencephaly10.1
42intellectual disability10.1
43cerebral atrophy10.1
44dysphagia10.1
45myoclonus10.1
46eating seizures10.1
47seminoma10.0ALPP, POMC
48neonatal infective mastitis10.0AKT3, DCX, POMC
49gaba aminotransferase deficiency10.0GABRA1, KCNQ2, SCN1A, TBC1D24
50peyronie's disease10.0KCNQ2, MT-ND1, POMC, ST3GAL3, TBC1D24

Graphical network of the top 20 diseases related to Lennox-Gastaut Syndrome:



Diseases related to lennox-gastaut syndrome

Symptoms for Lennox-Gastaut Syndrome

About this section

UMLS symptoms related to Lennox-Gastaut Syndrome:


hemiplegia, seizures, epileptic aura, seizures, tonic, myoclonus, eyelid, seizures, focal, convulsion in childhood

Drugs & Therapeutics for Lennox-Gastaut Syndrome

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Drugs for Lennox-Gastaut Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
MelatoninNutraceuticalPhase 424573-31-4896
Synonyms:
0E2B08C1-B325-45B1-8939-6F9081EFDFA4
4-ACETAMIDO-4'-ISOTHIO-CYANATOSTILBENE-2,2'-DISULFONIC ACID
5-22-12-00042 (Beilstein Handbook Reference)
5-Methoxy-N-acetyltryptamine
5-methoxy-N-acetyltryptamine
73-31-4
A4039/0172195
AB00053279
AC1L1A9Q
AC1Q4F1W
AC1Q4F1X
AKOS000276269
Acetamide, N-(2-(5-methoxy-1H-indol-3-yl)ethyl)- (9CI)
Acetamide, N-[2-(5-methoxy-1H-indol-3-yl)ethyl]- (9CI)
Acetamide, N-[2-(5-methoxyindol-3-yl)ethyl]- (6CI,8CI)
Acetamide, {N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-}
Acetamide, {N-[2-(5-methoxyindol-3-yl)ethyl]-}
BAS 01281092
BIDD:ER0618
BPBio1_000590
BRD-K97530723-001-07-6
BRN 0205542
BSPBio_000536
BSPBio_003006
Bio-0635
C01598
CAS-73-31-4
CCRIS 3472
CHEBI:16796
CHEMBL45
CID896
ChemDiv2_003916
Circadin
D008550
D08170
DB01065
DB08189
DivK1c_000353
EINECS 200-797-7
EU-0100787
HMS1380B22
HMS1569K18
HMS1921E04
HMS2089F09
HMS501B15
HSCI1_000400
HSDB 7509
I05-0076
I10-0345
IDI1_000353
IDI1_002631
IN1244
KBio1_000353
KBio2_000665
KBio2_003233
KBio2_005801
KBio3_002226
KBioGR_000591
KBioSS_000665
L001261
LS-1623
Lopac-M-5250
Lopac0_000787
M 5250
M-1200
M-1250
M1105
M5250_SIGMA
ML1
MLS000859594
MLS001055382
MLS001240204
MT6
Mela-T
Melapure
Melatol
Melatonex
Melatonex, Melatonin
Melatonin
Melatonin (synth.) standard-grade
 
Melatonin (synth.) ultra-pure
Melatonina
Melatonina (TN)
Melatonine
Melovine
MolPort-000-737-883
N-(2-(5-Methoxy-1H-indol-3-yl)ethyl)acetamide
N-(2-(5-Methoxyindol-3-yl)ethyl)-Acetamide
N-(2-(5-Methoxyindol-3-yl)ethyl)acetamide
N-Acetyl-5-methoxy-tryptamine
N-Acetyl-5-methoxy-tryptamine Melatonine
N-Acetyl-5-methoxytryptamine
N-[2-(5-Methoxy-1H-indol-3-yl)-ethyl]-acetamide
N-[2-(5-Methoxy-1H-indol-3-yl)ethyl)acetamide
N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]-Acetamide
N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]acetamide
N-[2-(5-Methoxyindol-3-yl)ethyl]-Acetamide
N-[2-(5-Methoxyindol-3-yl)ethyl]acetamide
N-[2-(5-methoxyindol-3-yl)ethyl]acetamide
N-acetyl-5-methoxy-tryptamine
NCGC00015680-01
NCGC00015680-02
NCGC00015680-03
NCGC00015680-06
NCGC00015680-13
NCGC00090727-01
NCGC00090727-02
NCGC00090727-03
NCGC00090727-04
NCGC00090727-05
NCGC00090727-06
NCGC00090727-07
NCGC00090727-08
NCGC00090727-09
NCI60_004378
NINDS_000353
NMR/14327425
NSC 113928
NSC113928
NSC56423
Nature'S Harmony
Night Rest
Oprea1_104553
Oprea1_814234
PREVENTION 1 (MELATONIN) (PREVENTION 1)
PREVENTION 2 (MELATONIN)
PREVENTION 3 (MELATONIN)
PREVENTION 4 (MELATONIN)
PREVENTION 5 (MELATONIN)
Pineal Hormone
Posidorm
Prestwick0_000458
Prestwick1_000458
Prestwick2_000458
Prestwick3_000458
Prestwick_312
Regulin
Revital Melatonin
Rx Balance
S1204_Selleck
SDCCGMLS-0065812.P001
SDCCGMLS-0065812.P002
SMP2_000309
SMR000326666
SPBio_001527
SPBio_002475
SPECTRUM1500690
STK386880
Sleep Right
Spectrum2_001344
Spectrum3_001393
Spectrum4_000066
Spectrum5_001745
Spectrum_000185
TNP00300
UNII-JL5DK93RCL
Vivitas
WLN: T56 BMJ D2MV1 GO1
ZINC00057060
{N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-} Acetamide
{N-[2-(5-methoxyindol-3-yl)ethyl]-} Acetamide
2
TopiramatePhase 3, Phase 124497240-79-45284627
Synonyms:
-D-fructopyranose deriv.
.beta.-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, sulfamate (9CI)
2,3-4,5-bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate
2,3:4,5-Bis-O-(1-methylethylidene) .beta.-D-fructopyranose sulfamate
2,3:4,5-Bis-O-(1-methylethylidene)-36-D-fructo-pyranose sulfamate
2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate
2,3:4,5-Di- O -isopropylidene-(beta)-D-fructopyranose sulfamate
2,3:4,5-Di-O-isopropylidene-beta-D-fructopyranose sulfamate
5H-Bis[1,3]dioxolo[4,5-b:4',5'-d]pyran, .beta.
97240-79-4
AKOS000424547
BIDD:GT0854
BIDD:PXR0127
BRN 5988957
BSPBio_002306
C052342
C07502
C12H21NO8S
CBChromo1_000352
CHEBI:129573
CHEMBL220492
CID5284627
CPD000466325
Cilag brand of topiramate
D00537
DB00273
Epitoma
Epitomax
HMS1922H06
HMS2051L09
HMS2093D20
HSDB 7531
Janssen brand of topiramate
KS-1122
KW-6485
LS-187392
LS-69764
MLS000759431
MLS001424070
McN 4853
McN-4853
MolPort-001-615-062
MolPort-002-885-869
NCGC00178714-01
 
Ortho brand of topiramate
RWJ 17021
RWJ-17021
RWJ-17021-000
S1438_Selleck
SAM001246601
SMR000466325
SPBio_000995
SPECTRUM1505801
STOCK1N-71037
Spectrum2_001128
T0575_SIGMA
TL8006021
TOR
TPM
Tipiramate
Tipiramate [French]
Tipiramato
Tipiramato [Spanish]
Topamac
Topamax
Topamax (TN)
Topamax Sprinkle
Topamax, Topiramate
Topimax
Topina
Topiramate
Topiramate (JAN/USAN/INN)
Topiramate (TPM)
Topiramate / Placebo
Topiramate [USAN:BAN:INN]
Topiramato
Topiramato [INN-Spanish]
Topiramatum
Topiramatum [INN-Latin]
Topiramic acid
Topomax
UNII-0H73WJJ391
USL-255
[(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate
beta-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, sulfamate
beta.-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, 1-sulfamate
topiramate
topiramate tablet
topiramatum [Latin]
3sodium fluoridePhase 31787681-49-4
4
EthanolPhase 3197164-17-5702
Synonyms:
(C6-C9)Alkyl alcohol
02483_FLUKA
02851_FLUKA
02853_FLUKA
02854_FLUKA
02855_FLUKA
02856_FLUKA
02856_SIAL
02857_FLUKA
02857_SIAL
02858_FLUKA
02858_SIAL
02860_FLUKA
02865_FLUKA
02865_SIAL
02870_FLUKA
02870_SIAL
02875_FLUKA
02877_FLUKA
02878_FLUKA
02882_FLUKA
02882_SIAL
02883_FLUKA
02884_FLUKA
02890_FLUKA
02890_SIAL
02891_FLUKA
02891_SIAL
1-Hydroxyethane
100C.NPA
121182-78-3
187380_ALDRICH
187380_SIAL
24102_RIEDEL
24102_SIAL
24103_RIEDEL
24103_SIAL
24105_RIEDEL
24105_SIAL
24106_RIEDEL
24106_SIAL
24194_RIEDEL
24194_SIAL
245119_ALDRICH
245119_SIAL
270741_ALDRICH
270741_SIAL
277649_ALDRICH
277649_SIAL
2858_SIGMA
29221_FLUKA
32205_RIEDEL
32205_SIAL
32221_RIEDEL
32221_SIAL
32294_RIEDEL
32294_SIAL
34870_SIAL
34963_RIEDEL
39278_FLUKA
40210_ALDRICH
40210_RIEDEL
41322_FLUKA
458600_ALDRICH
458600_SIAL
459828_ALDRICH
459828_SIAL
459836_ALDRICH
459836_SIAL
459844_SIAL
48075_SUPELCO
493511_SIAL
493538_ALDRICH
493538_SIAL
493546_ALDRICH
493546_SIAL
64-17-5
676829_SIAL
68475-56-9
71076-86-3
71329-38-9
8000-16-6
8024-45-1
AC1L19TW
AC1Q31MM
AHD 2000
AI3-01706
ALCOHOL 5% IN D5-W
Absolute Alcohol
Absolute Ethanol
Absolute alcohol
Absolute ethanol
Absolute ethyl alcohol
Aethanol
Aethanol [German]
Aethylalkohol
Alcare Hand Degermer
Alcohol
Alcohol (USP)
Alcohol (ethyl)
Alcohol Anhydrous
Alcohol [USP]
Alcohol anhydrous
Alcohol dehydrated
Alcohol denatured
Alcohol etílico
Alcohol, Absolute
Alcohol, Dehydrated
Alcohol, Diluted
Alcohol, Grain
Alcohol, anhydrous
Alcohol, dehydrated
Alcohol, denatured
Alcohol, diluted
Alcohol, ethyl
Alcohols
Alcohols, C1-3
Alcohols, C30
Alcohols, C6-9
Alcool Ethylique
Alcool Etilico
Alcool ethylique
Alcool etilico
Alcool éthylique
Algrain
Alkohol
Alkohol [German]
Alkoholu Etylowego
Alkoholu etylowego
Aminoethanol
Anhydrol
Anhydrol PM 4085
Anhydrous alcohol
Anhydrous ethanol
Beta-Aminoethanol
Beta-Aminoethyl Alcohol
Beta-Ethanolamine
Beta-Hydroxyethylamine
C00469
C2H5OH
C2H6O
CCRIS 945
CDA 19
CDA 19-200
CHEBI:16236
CHEMBL545
CID702
Caswell No. 426
Caswell No. 430
Colamine
Cologne Spirit
Cologne spirit
Cologne spirits
 
D000431
D00068
DB00898
Dehydrated Ethanol
Dehydrated alcohol
Dehydrated ethanol
Denatured Alcohol
Denatured Alcohol Cd-10
Denatured Alcohol Cd-5
Denatured Alcohol Cd-5a
Denatured Alcohol Sd-1
Denatured Alcohol Sd-13a
Denatured Alcohol Sd-17
Denatured Alcohol Sd-23a
Denatured Alcohol Sd-28
Denatured Alcohol Sd-30
Denatured Alcohol Sd-39b
Denatured Alcohol Sd-39c
Denatured Alcohol Sd-3a
Denatured Alcohol Sd-40m
Denatured Ethanol
Denatured alcohol
Denatured ethanol
Desinfektol EL
Diluted Alcohol
Distilled spirits
E2385_SIGMA
E7023_ALDRICH
E7023_SIAL
E7148_ALDRICH
E7148_SIAL
E7517_SIGMA
EINECS 200-578-6
EINECS 270-649-4
EOH
EOX
ETA
Envision Conditioner Pdd 9020
Esumiru WK 88
EtOH
Etanolo
Etanolo [Italian]
Ethanol (9CI)
Ethanol 200 Proof
Ethanol 200 proof
Ethanol Absolute
Ethanol Absolute Bp
Ethanol Anhydrous
Ethanol Extra Pure
Ethanol Vapor
Ethanol [JAN]
Ethanol solution
Ethanol, Silent Spirit
Ethanol, undenatured
Ethanolum anhydricum
Ethicap
Ethyl Alcohol
Ethyl Alcohol & Water, 10%
Ethyl Alcohol & Water, 20%
Ethyl Alcohol & Water, 30%
Ethyl Alcohol & Water, 40%
Ethyl Alcohol & Water, 5%
Ethyl Alcohol & Water, 50%
Ethyl Alcohol & Water, 60%
Ethyl Alcohol & Water, 70%
Ethyl Alcohol & Water, 80%
Ethyl Alcohol & Water, 95%
Ethyl Alcohol & Water, 96%
Ethyl Alcohol Anhydrous
Ethyl Alcohol, Anhydrous
Ethyl Alcohol, Denatured
Ethyl Hydrate
Ethyl Hydroxide
Ethyl alc
Ethyl alcohol
Ethyl alcohol anhydrous
Ethyl alcohol in alcoholic beverages
Ethyl alcohol usp
Ethyl hydrate
Ethyl hydroxide
Ethylalcohol
Ethylalcohol [Dutch]
Ethylol
Ethylolamine
Ethyloxy Group
Etylowy alkohol
FEMA No. 2419
FEMA Number 2419
Fermentation alcohol
Glycinol
Grain alcohol
HSDB 531
HSDB 82
HYDROXYETHYL GROUP
Hinetoless
Hydroxyethane
I14-12648
IMS 99
Infinity Pure
Jaysol
Jaysol S
LS-1539
LTBB002977
Lux
Methylated Spirit Mineralised
Methylated spirit
Methylcarbinol
MolPort-001-785-844
Molasses alcohol
NCGC00091458-01
NCI-C03134
NSC 85228
NSC85228
Oxydimethylene Group
Potato alcohol
Punctilious ethyl alcohol
Pyro
QMHAIh@
Reagent Alcohol
Ru-Tuss Expectorant
SDA 3A
SDA 40-2
SDM No. 37
SY Fresh M
Sekundasprit
Silent spirit
Spirit
Spirits of wine
Spiritus vini
Spirt
Synasol
Tecsol
Tecsol C
Thanol
Thiofaco M-50
UNII-3K9958V90M
USAF EK-1597
Undenatured Ethanol
WLN: Q2
absolute alcohol
alcohol
alcohol etilico
bmse000297
etanol
ethanol
ethyl alcohol
grain alcohol
nchem.651-comp3c
nchembio.552-comp10
nchembio.94-comp20
spiritus vini
Äthanol
Äthylalkohol
éthanol
5
ClobazamPhase 3, Phase 22022316-47-82789
Synonyms:
1-Phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-diketo-3H-1,5-benzodiazepine
1-Phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-dioxo-3H-1, 5-benzodiazepine
1-Phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-dioxo-3H-1,5-benzodiazepine
1-phenyl-5-methyl-8-chloro-1,2,4,5- tetrahydro-2,4-diketo-3H-1,5-benzodiazepine
1-phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-dioxo-3H-1,5-benzodiazepine
22316-47-8
4(3H,5H)-dione
5-24-08-00034 (Beilstein Handbook Reference)
7-Chloro-1-methyl-5-phenyl-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione
7-Chloro-1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,
7-Chloro-1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione
7-Chloro-1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,4-(3H,5H)-dione
7-chloro-1-methyl-5-phenyl-1,5-benzodiazepine-2,4-dione
AC-273
AC1L1EGZ
Ambap22316-47-8
BRN 0758410
C012255
C8414_SIGMA
CCRIS 7506
CHEBI:31413
CHEMBL70418
CID2789
Caastilium
Chlorepin
Clobazam
Clobazam (JAN/USAN/INN)
Clobazam [USAN:BAN:INN]
Clobazamum
 
Clobazamum [INN-Latin]
Clorepin
D01253
DB00349
DEA No. 2751
EINECS 244-908-7
Frisium
H 4723
H-4723
HR 376
LM 2717
LM-2717
LS-34098
MolPort-003-940-848
Mystan
Mystan (TN)
NCGC00168249-01
NSC 336279
NSC336279
Noiafren
Odipam
RU-4723
UNII-2MRO291B4U
Urbadan
Urbanil
Urbanyl
WLN: T67 GNV JVN IHJ CG G1 KR
ZINC00001175
clobazam
nchembio747-comp39
6
BenzocainePhase 317941994-09-7, 94-09-72337
Synonyms:
(p-(Ethoxycarbonyl)phenylamine
06952_FLUKA
112909_ALDRICH
112909_SIAL
1333-08-0
23239-88-5
23239-88-5 (hydrochloride)
4 Aminobenzoic Acid Ethyl Ester
4-(Ethoxycarbonyl)aniline
4-(Ethoxycarbonyl)phenylamine
4-14-00-01129 (Beilstein Handbook Reference)
4-Aminobenzoate
4-Aminobenzoic acid
4-Aminobenzoic acid ethyl ester
4-Aminobenzoic acid, ethyl ester
4-Carbethoxyaniline
4-amino-benzoic acid ethyl ester
4-aminobenzoic acid ethyl ester
71123-91-6
94-09-7
94-09-7 (Parent)
A0271
AB00051923
AC1L1DGC
AC1Q341A
AC1Q64JE
AE-562/40377256
AI3-02081
AKOS000119763
AR-1H9065
Acetate, Benzocaine
Aethoform
Aethylium paraminobenzoicum
Amben ethyl ester
Americaine
Anaesthan-syngala
Anaesthesin
Anaesthesinum
Anaesthin
Anestezin
Anestezin [Russian]
Anesthesin
Anesthesine
Anesthone
BB_SC-0019
BPBio1_001017
BRD-K75466013-001-05-2
BRN 0638434
BSPBio_000923
BSPBio_001908
Baby Anbesol
Bensokain
Benzoak
Benzocaina
Benzocaina [INN-Spanish]
Benzocaine
Benzocaine (USP/INN)
Benzocaine Acetate
Benzocaine Formate
Benzocaine Hydrobromide
Benzocaine Hydrochloride
Benzocaine Methanesulfonate
Benzocaine [INN:BAN]
Benzocainum
Benzocainum [INN-Latin]
Benzoic acid, 4-amino-, ethyl ester
Benzoic acid, 4-amino-, ethyl ester, hydrochloride
Benzoic acid, amino-, ethyl ester
Benzoic acid, p-amino-, ethyl ester
C07527
CAS-94-09-7
CHEBI:116735
CHEMBL278172
CID2337
Caswell No. 430A
Chloraseptic
D001566
D00552
DB01086
Dermoplast
Diet Ayds
DivK1c_000932
E1501_SIGMA
EINECS 202-303-5
EPA Pesticide Chemical Code 097001
ETHYL-P-AMINOBENZOATE
Ethoform
Ethoforme
Ethyl 4-aminobenzoate
Ethyl 4-aminobenzoate hydrochloride
Ethyl 4-aminobenzoic acid
Ethyl Aminobenzoate
Ethyl PABA
 
Ethyl aminobenzoate
Ethyl aminobenzoate (JP15)
Ethyl aminobenzoate (VAN)
Ethyl aminobenzoic acid
Ethyl p-Aminobenzoate
Ethyl p-Aminophenylcarboxylate
Ethyl p-aminobenzenecarboxylate
Ethyl p-aminobenzoate
Ethyl p-aminobenzoic acid
Ethyl p-aminophenylcarboxylate
Ethylester kyseliny p-aminobenzoove
Ethylester kyseliny p-aminobenzoove [Czech]
Ethylis aminobenzoas
Formate, Benzocaine
HMS1570O05
HMS1920G09
HMS2091M11
HMS502O14
HSDB 7225
Hurricaine
Hydrobromide, Benzocaine
Hydrochloride, Benzocaine
I05-0204
IDI1_000932
Identhesin
KBio1_000932
KBio2_000474
KBio2_003042
KBio2_005610
KBio3_001408
KBioGR_000658
KBioSS_000474
Keloform
LS-35847
MLS001331704
MLS002153970
Methanesulfonate, Benzocaine
MolPort-000-871-526
NCGC00016352-01
NCGC00094598-01
NCGC00094598-02
NINDS_000932
NSC 122792
NSC 41531
NSC41531
NSC4688
Norcain
Norcaine
Norcainum
Oprea1_750694
Oprea1_827402
Ora-jel
Orabase-B
Orthesin
Otocain
Outgro
Parathesin
Parathesin (TN)
Parathesine
Prestwick0_000712
Prestwick1_000712
Prestwick2_000712
Prestwick3_000712
Prestwick_991
SMR000059025
SPBio_000134
SPBio_002844
SPECTRUM1500139
STK043620
Slim Mint Gum
Solarcaine
Solu H
Spectrum2_000117
Spectrum3_000314
Spectrum4_000249
Spectrum5_000860
Spectrum_000074
Topcaine
UNII-U3RSY48JW5
WLN: ZR DVO2
ZINC12358719
benzocaine
ethylaminobenzoate-4
h-4-abz-oet
nchembio.182-comp4
p-(Ethoxycarbonyl)aniline
p-Aminobenzoate
p-Aminobenzoic acid
p-Aminobenzoic acid ethyl ester
p-Aminobenzoic acid, ethyl ester
p-Aminobenzoic ethyl ester
p-Carbethoxyaniline
p-Ethoxycarboxylic Aniline
p-Ethoxycarboxylic aniline
7
retigabinePhase 3, Phase 227150812-12-7121892
Synonyms:
150812-12-7
AC-6908
AC1L3TLD
ADD-230001
C101866
C13826
C16H18FN3O2
CHEBI:161945
CHEMBL41355
CID121892
Carbamic acid, (2-amino-4-(((4-fluorophenyl)methyl)amino)phenyl)-, ethyl ester
D 20443
D 23129
D-20443
D-23129
EZG
Ethyl (2-amino-4-(((4-fluorophenyl)methyl)amino)phenyl)carbamate
Ethyl 2-amino-4-((P-fluorobenzyl)amino)carbanilate
Ethyl 2-amino-4-((p-fluorobenzyl)amino)carbanilate
Ethyl {2-amino-4-[(4-fluorobenzyl)amino]phenyl}carbamate
 
Ezogabine
FT-0080801
GKE-841
I06-0810
KE-0201
LS-48932
MolPort-003-850-148
N-(2-Amino-4-(4-fluorobenzylamino)-phenyl) carbamic acid ethyl ester
N-(2-Amino-4-(4-fluorobenzylamino)phenyl)carbamic acid ethyl ester
Potiga
RTG
Retigabine
Retigabine [USAN]
TL80090034
Trobalt
UNII-12G01I6BBU
ZINC00016154
[2-Amino-4-[[(4-fluorophenyl)methyl]amino]phenyl]-carbamate
ethyl N-(2-amino-4-(4-fluorobenzylamino)phenyl)carbamate hydrochloride
ethyl N-[2-amino-4-[(4-fluorophenyl)methylamino]phenyl]carbamate
nchembio874-comp3
8tannic acidNutraceuticalPhase 31794
9
SerotoninPhase 2351050-67-95202
Synonyms:
3-(2-Aminoethyl)-1H-indol-5-ol
3-(2-Aminoethyl)indol-5-ol
3-(b-Aminoethyl)-5-hydroxyindole
5-HT
5-HTA
5-Hydroxy-3-(b-aminoethyl)indole
 
5-Hydroxy-tryptamine
5-Hydroxyltryptamine
5-Hydroxytriptamine
5-Hydroxytryptamine
Antemovis
DS substance
Enteramin
Enteramine
10
fenfluraminePhase 29458-24-23337
Synonyms:
()-Fenfluramine hydrochloride
(+)-Fenfluramine
(+-)-Fenfluramine
(+/-)-Fenfluramine hydrochloride
(S)-Fenfluramine
1-(m-trifluoromethyl-phenyl)-2-ethylaminopropane
1-(meta-Trifluoromethyl-phenyl)-2 ethylaminopropane
2-Ethylamino-1-(3-trifluoromethylphenyl)propane
3-(Trifluoromethyl)-N-ethyl-alpha-methylphenethylamine
3239-44-9
404-82-0 (hydrochloride)
458-24-2
5220-89-3
AC-16024
AC1L1FPE
AC1Q31EZ
AC1Q31F0
Acino
Adifax
Adipomin
BRN 4783711
Benzeneethanamine, N-ethyl-alpha-methyl-3-(trifluoromethyl)- (9CI)
Benzeneethanamine, N-ethyl-alpha-methyl-3-(trifluoromethyl)-, (+-)- (9CI)
Benzeneethanamine, N-ethyl-alpha-methyl-3-(trifluoromethyl)-, (S)- (9CI)
C06996
C12H16F3N
CHEBI:5000
CHEMBL87493
CID3337
D07945
DB00574
DB01191
DEA No. 1670
Dexafenfluramine
Dexfenfluramina
Dexfenfluramina [Spanish]
Dexfenfluramine
Dexfenfluramine [INN:BAN]
Dexfenfluraminum
Dexfenfluraminum [Latin]
 
Dextrofenfluramine
DivK1c_000980
EINECS 207-276-3
Fenfluramina
Fenfluramina [DCIT]
Fenfluramine (INN)
Fenfluramine [INN:BAN]
Fenfluramine, (+-)-Isomer
Fenfluraminum
Fenfluraminum [INN-Latin]
HSDB 3080
HSDB 7356
IDI1_000980
Isomeride
KBio1_000980
L000742
LS-103505
LS-103506
LS-103507
Levofenfluramine [INN]
MolPort-001-794-054
N-Ethyl-alpha-methyl-3-(trifluoromethyl)benzeneethanamine
N-Ethyl-alpha-methyl-3-trifluoromethylphenethylamine
N-Ethyl-alpha-methyl-m-(trifluoromethyl)phenethylamine
N-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine
NCGC00159473-02
NCGC00159473-03
NCGC00159473-04
NINDS_000980
Obedrex
Pesos
Ponderax (TN)
Ponderax PA
Ponderex
Prestwick_868
Rotondin
S 768
UNII-2DS058H2CF
d-Fenfluramine
d-N-Ethyl-alpha-methyl-m-trifluoromethylphenethylamine
fenfluramine
11
Lamotrigine18284057-84-13878
Synonyms:
3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine
3,5-Diamino-6-(2,3-dichlorophenyl)-as-triazine
3,5-diamino-6-(2,3-dichlorophenyl)- as -triazine
6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diyldiamine
6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine
84057-84-1
AC-10298
AC1L1GWT
BIDD:GT0794
BW 430C
BW-430C
Bio-0056
C047781
CHEBI:138727
CHEBI:6367
CHEMBL741
CID3878
CPD000058464
Crisomet
D00354
DB00555
Desitin Brand of Lamotrigine
EINECS 281-901-8
EU-0100688
EUR-1048
Faes Brand of Lamotrigine
GI 267119X
GW 273293
Glaxo Wellcome Brand of Lamotrigine
GlaxoSmithKline Brand of Lamotrigine
HMS2051C10
HMS2089M08
HMS2093P21
HSDB 7526
Juste Brand of Lamotrigine
L 3791
L3791_SIGMA
LS-155249
 
Labileno
Lamictal
Lamictal (TN)
Lamictal CD
Lamictal Cd
Lamictal ODT
Lamictal XR
Lamictin
Lamiktal
Lamitor
Lamotrigina
Lamotrigina [Spanish]
Lamotrigine
Lamotrigine (JAN/USAN/INN)
Lamotrigine [USAN:INN:BAN]
Lamotriginum
Lamotriginum [Latin]
Lopac-L-3791
Lopac0_000688
MLS000069685
MLS000759486
MLS001077325
MolPort-003-666-744
NCGC00015605-01
NCGC00015605-02
NCGC00015605-06
NCGC00015605-08
NCGC00022936-02
NCGC00022936-04
NCGC00022936-05
NSC746307
SAM001246697
SMP2_000303
SMR000058464
STK628377
Tocris-1611
UNII-U3H27498KS
ZINC00013156
lamotrigine
12calcium channel blockers1889

Interventional clinical trials:

(show all 31)
idNameStatusNCT IDPhase
1Transcranial Direct Current Stimulation, Treatment of Childhood Drug-Resistant Lennox-Gastaut Syndrome, A Pilot StudyCompletedNCT02731300Phase 4
2Melatonin Versus Placebo in the Lennox-Gastaut Syndrome: Neurophysiological and Neuropsychological EffectsNot yet recruitingNCT01370486Phase 4
3Safety and Effectiveness of Open-Label Clobazam in Subjects With Lennox-Gastaut SyndromeCompletedNCT01160770Phase 3
4A Placebo-Controlled, Double-Blind Comparative Study of E2080 in Lennox-Gastaut Syndrome Patients (Study E2080-J081-304)CompletedNCT01146951Phase 3
5A Study to Investigate the Efficacy and Safety of Cannabidiol (GWP42003-P; CBD) as Adjunctive Treatment for Seizures Associated With Lennox-Gastaut Syndrome in Children and AdultsCompletedNCT02224690Phase 3
6A Study to Investigate the Efficacy and Safety of Cannabidiol (GWP42003-P; CBD) as Adjunctive Treatment for Seizures Associated With Lennox-Gastaut Syndrome in Children and AdultsCompletedNCT02224560Phase 3
7Study of Rufinamide in Pediatric Subjects 1 to Less Than 4 Years of Age With Lennox-Gastaut Syndrome Inadequately Controlled With Other Anti-epileptic DrugsCompletedNCT01405053Phase 3
8Phase III Randomized, Double-Blind, Placebo-Controlled Study of Oral Topiramate for Lennox-Gastaut SyndromeCompletedNCT00004776Phase 3
9Clobazam in Patients With Lennox-Gastaut SyndromeCompletedNCT00518713Phase 3
10A Study of the Efficacy and Safety of Topiramate as an add-on Therapy in the Treatment of Epilepsy Patients With Lennox-Gastaut SyndromeCompletedNCT00236756Phase 3
11A Long Term Extension Study of E2080 in Lennox-Gastaut PatientsCompletedNCT01151540Phase 3
12Study to Determine the Efficacy and Safety of Adjunctive Topiramate in the Treatment of Obsessive-Compulsive DisorderCompletedNCT00187928Phase 3
13An Open Label Extension Study of Cannabidiol (GWP42003-P) in Children and Young Adults With Dravet or Lennox-Gastaut SyndromesEnrolling by invitationNCT02224573Phase 3
14Cannabidiol Oral Solution as an Adjunctive Treatment for Treatment-resistant Seizure DisorderEnrolling by invitationNCT02318602Phase 3
15Study of Perampanel as Adjunctive Treatment for Inadequately Controlled Seizures Associated With Lennox-Gastaut SyndromeNot yet recruitingNCT02834793Phase 3
16Cannabidiol Oral Solution as an Adjunctive Therapy for Treatment of Subjects With Inadequately Controlled Lennox-Gastaut SyndromeNot yet recruitingNCT02318537Phase 3
17Long-term, Open-label Safety Extension Study of Retigabine/Ezogabine in Pediatric Subjects (>= 12 Years Old) With POS or LGSTerminatedNCT01668654Phase 3
18Clobazam in Subjects With Lennox-Gastaut SyndromeCompletedNCT00162981Phase 2
19Add-on Therapy With Low Dose Fenfluramine in Lennox Gastaut EpilepsyRecruitingNCT02655198Phase 2
20Study in Pediatric Subjects With EpilepsyTerminatedNCT01494584Phase 2
21A Study of the Pharmacokinetics, Safety and Tolerability of Topiramate in Infants (Age 1-24 Months) With Refractory Partial-onset SeizuresCompletedNCT00233012Phase 1
22European Registry of Anti-Epileptic Drug Use in Patients With Lennox-Gastaut Syndrome (LGS)CompletedNCT01991041
23Ketogenic Diet for Child Epilepsy and Seizure ControlCompletedNCT00004729
24A Study of the Safety of Topiramate Given in Combination With Other Medications in Adults and Children With SeizuresCompletedNCT00297349
25Metabolic Abnormalities in Children With EpilepsyCompletedNCT00001325
26Trial to Assess Vagus Nerve Stimulation Therapy in Children With Lennox-Gastaut SyndromeRecruitingNCT02632149Phase 0
27Post-marketing Surveillance of Long-term Administration of Inovelon Tablets in Patients With Lennox-Gastaut SyndromeRecruitingNCT02175173
28Epilepsy Phenome/Genome ProjectActive, not recruitingNCT00552045
29Special Drug Use Investigation for LAMICTAL® (Long Term)Active, not recruitingNCT01863602
30The Pharmacokinetics of Cannabidiol (CBD) and Its Effects in Children With Severe EpilepsyNot yet recruitingNCT02910297
31The Effects of Cannabidiol (CBD) on Electrical and Autonomic Cardiac Function in Children With Severe EpilepsyNot yet recruitingNCT02815540

Search NIH Clinical Center for Lennox-Gastaut Syndrome

Genetic Tests for Lennox-Gastaut Syndrome

About this section

Genetic tests related to Lennox-Gastaut Syndrome:

id Genetic test Affiliating Genes
1 Epileptic Encephalopathy Lennox-Gastaut Type25
2 Epileptic Encephalopathy, Lennox-Gastaut Type23 MAPK10

Anatomical Context for Lennox-Gastaut Syndrome

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MalaCards organs/tissues related to Lennox-Gastaut Syndrome:

34
Brain, Eye, Cortex, Thalamus, Liver, Heart

Animal Models for Lennox-Gastaut Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Lennox-Gastaut Syndrome:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053897.9AKT3, CHD2, DCX, EMX2, GABRA1, KCNQ2
2MP:00036316.6AKT3, DCX, DNM1, EMX2, GABRA1, GABRB2
3MP:00053866.2AKT3, CHD2, DCX, DNM1, EMX2, GABRA1

Publications for Lennox-Gastaut Syndrome

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Articles related to Lennox-Gastaut Syndrome:

(show top 50)    (show all 292)
idTitleAuthorsYear
1
Clobazam-treated patients with Lennox-Gastaut syndrome experienced fewer seizure-related injuries than placebo patients during trial OV-1012. (27145465)
2016
2
Predictive role of brain connectivity for resective surgery in Lennox-Gastaut syndrome. (27417063)
2016
3
Safety and pharmacokinetic profile of rufinamide in pediatric patients aged less than 4 years with Lennox-Gastaut syndrome: An interim analysis from a multicenter, randomized, active-controlled, open-label study. (26805435)
2016
4
Comprehensive overview: efficacy, tolerability, and cost-effectiveness of clobazam in Lennox-Gastaut syndrome. (26089675)
2015
5
Lennox-Gastaut syndrome may be a curable, reversible epileptic encephalopathy. (25778755)
2015
6
Lennox-Gastaut syndrome: impact on the caregivers and families of patients. (25336963)
2014
7
Efficacy and tolerability of add-on Lacosamide in children with Lennox-Gastaut syndrome. (25052288)
2014
8
Withdrawal-related adverse events from clinical trials of clobazam in Lennox-Gastaut syndrome. (24949576)
2014
9
Glycemic index treatment using Japanese foods in a girl with Lennox-Gastaut syndrome. (23583057)
2013
10
Whole-exome sequencing identifies a variant of the mitochondrial MT-ND1 gene associated with epileptic encephalopathy: west syndrome evolving to Lennox-Gastaut syndrome. (24105702)
2013
11
Efficacy of the ketogenic diet in Lennox-Gastaut syndrome: a retrospective review of one institution's experience and summary of the literature. (22443637)
2012
12
Post-section recruitment of epileptiform discharges in electrocorticography during callosotomy in 48 patients with Lennox-Gastaut syndrome. (22281384)
2012
13
Localization of ictal onset zones in Lennox-Gastaut syndrome (LGS) based on information theoretical time delay analysis of intracranial electroencephalography (iEEG). (22071552)
2012
14
Surgical treatment of patients with Lennox-Gastaut syndrome phenotype. (22629163)
2012
15
Cortical excitability decreases in Lennox-Gastaut syndrome. (22813348)
2012
16
Management of seizures in Lennox-Gastaut syndrome. (21351810)
2011
17
Localization of ictal onset zones in Lennox-Gastaut syndrome using directed transfer function method. (22255466)
2011
18
Introduction: Transitioning care for adults with Lennox-Gastaut syndrome: challenges and promises. (21790559)
2011
19
Rufinamide for the treatment of Lennox-Gastaut syndrome. (21348771)
2011
20
Medical management of Lennox-Gastaut syndrome. (20158289)
2010
21
Does lacosamide aggravate Lennox-Gastaut syndrome? Report on three consecutive cases. (20970386)
2010
22
Lennox-Gastaut syndrome: a consensus approach on diagnosis, assessment, management, and trial methodology. (19081517)
2009
23
Treatment of Lennox-Gastaut syndrome. (19588340)
2009
24
Late-onset Lennox-Gastaut syndrome in a patient with 15q11.2-q13.1 duplication. (19396834)
2009
25
Comparison of corpus callosotomy and vagus nerve stimulation in children with Lennox-Gastaut syndrome. (17825516)
2008
26
Vagus nerve stimulation improves severely impaired heart rate variability in a patient with Lennox-Gastaut-Syndrome. (18096413)
2008
27
Delayed response of seizures with vagus nerve stimulation in Lennox-Gastaut syndrome. (15505192)
2004
28
Lennox-Gastaut syndrome (childhood epileptic encephalopathy). (14734932)
2003
29
Drug therapy in Lennox-Gastaut syndrome. (11993742)
2002
30
Infantile spasms and Lennox-Gastaut syndrome. (11952036)
2002
31
Eating seizures in Lennox-Gastaut syndrome. (11244278)
2001
32
Vagus nerve stimulation treatment for Lennox-Gastaut syndrome. (10961788)
2000
33
A pilot study of topiramate in children with Lennox-Gastaut syndrome. (10412513)
1999
34
Can eliminating monosodium glutamate from the diet affect Lennox-Gastaut syndrome? (9710653)
1998
35
Lamotrigine for generalized seizures associated with the Lennox-Gastaut syndrome. Lamictal Lennox-Gastaut Study Group. (9400037)
1997
36
Case study. A child with Lennox-Gastaut syndrome. (8788700)
1996
37
Multifocal independent Spike syndrome: relationship to hypsarrhythmia and the slow spike-wave (Lennox-Gastaut) syndrome. (7882540)
1995
38
Behavioral effects of felbamate in childhood epileptic encephalopathy (Lennox-Gastaut syndrome). (8643784)
1995
39
Felbamate in the treatment of Lennox-Gastaut syndrome. (8039473)
1994
40
Lamotrigine as an add-on drug in the management of Lennox-Gastaut syndrome. (1490494)
1992
41
The Lennox-Gastaut syndrome. (3139482)
1988
42
Depth EEG studies in the Lennox-Gastaut syndrome. (3117442)
1987
43
Status epilepticus within the Lennox-Gastaut syndrome: clinical characteristics and management. (3109788)
1987
44
Cerebral glucose metabolism in the Lennox-Gastaut syndrome. (3103526)
1987
45
West syndrome evolving into the Lennox-Gastaut syndrome. (6697547)
1984
46
Secondary late-onset Lennox-Gastaut syndrome: a critical view. (6466153)
1984
47
Positron emission tomography in two cases of childhood epileptic encephalopathy (Lennox-Gastaut syndrome). (6981784)
1982
48
The Lennox-Gastaut syndrome: a personal study. (6811253)
1982
49
Tonic status epilepticus precipitated by intravenous benzodiazepine in five patients with Lennox-Gastaut syndrome. (4626571)
1972
50
The Lennox-Gastaut syndrome: a severe type of childhood epilepsy. (4979309)
1969

Variations for Lennox-Gastaut Syndrome

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Clinvar genetic disease variations for Lennox-Gastaut Syndrome:

5
id Gene Variation Type Significance SNP ID Assembly Location
1NM_006920.4(SCN1A): c.4874G> A (p.Arg1625Gln)single nucleotide variantLikely pathogenic, Pathogenicrs121917995GRCh37Chr 2, 166848878: 166848878

Expression for genes affiliated with Lennox-Gastaut Syndrome

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Search GEO for disease gene expression data for Lennox-Gastaut Syndrome.

Pathways for genes affiliated with Lennox-Gastaut Syndrome

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GO Terms for genes affiliated with Lennox-Gastaut Syndrome

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Cellular components related to Lennox-Gastaut Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1GABA receptor complexGO:190271010.1GABRA1, GABRB2
2GABA-A receptor complexGO:190271110.1GABRA1, GABRB2
3axon initial segmentGO:004319410.0KCNQ2, SCN1A
4node of RanvierGO:003326810.0KCNQ2, SCN1A

Biological processes related to Lennox-Gastaut Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1synaptic transmission, GABAergicGO:00519329.5DNM1, GABRA1, GABRB2
2cellular response to histamineGO:00714209.5GABRA1, GABRB2

Molecular functions related to Lennox-Gastaut Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1GABA receptor activityGO:001691710.0GABRA1, GABRB2
2GABA-A receptor activityGO:00048909.8GABRA1, GABRB2

Sources for Lennox-Gastaut Syndrome

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet