MCID: LNN001
MIFTS: 51

Lennox-Gastaut Syndrome malady

Categories: Genetic diseases, Rare diseases, Neuronal diseases

Aliases & Classifications for Lennox-Gastaut Syndrome

About this section
Sources:
10Disease Ontology, 45NIH Rare Diseases, 23Genetics Home Reference, 46NINDS, 47Novoseek, 12DISEASES, 51Orphanet, 65UMLS, 22GeneTests, 24GTR, 66UMLS via Orphanet, 28ICD10 via Orphanet, 37MESH via Orphanet
See all MalaCards sources

Aliases & Descriptions for Lennox-Gastaut Syndrome:

Name: Lennox-Gastaut Syndrome 10 45 23 46 47 12 51 65
Epileptic Encephalopathy, Lennox-Gastaut Type 22 24
Lennox Syndrome 10 65
Childhood Epileptic Encephalopathy with Diffuse Slow Spikes and Waves 23
 
Epileptic Encephalopathy Lennox-Gastaut Type 45
Encephalopathy of Childhood 45
Lgs 23

Characteristics:

Orphanet epidemiological data:

51
lennox-gastaut syndrome:
Inheritance: Autosomal dominant,Multigenic/multifactorial,Not applicable; Prevalence: 1-9/1000000 (Europe),1-5/10000 (Europe); Age of onset: Childhood

Classifications:



External Ids:

Disease Ontology10 DOID:0050561
Orphanet51 2382
UMLS via Orphanet66 C0238111
ICD10 via Orphanet28 G40.4
MESH via Orphanet37 C535500
UMLS65 C0238111, C0598392

Summaries for Lennox-Gastaut Syndrome

About this section
NINDS:46 Lennox-Gastaut syndrome is a severe form of epilepsy. Seizures usually begin before 4 years of age. Seizure types, which vary among patients, include tonic (stiffening of the body, upward deviation of the eyes, dilation of the pupils, and altered respiratory patterns), atonic (brief loss of muscle tone and consciousness, causing abrupt falls), atypical absence (staring spells), and myoclonic (sudden muscle jerks). There may be periods of frequent seizures mixed with brief, relatively seizure-free periods. Most children with Lennox-Gastaut syndrome experience some degree of impaired intellectual functioning or information processing, along with developmental delays, and behavioral disturbances. Lennox-Gastaut syndrome can be caused by brain malformations, perinatal asphyxia, severe head injury, central nervous system infection and inherited degenerative or metabolic conditions. In 30-35 percent of cases, no cause can be found.

MalaCards based summary: Lennox-Gastaut Syndrome, also known as epileptic encephalopathy, lennox-gastaut type, is related to acute necrotizing encephalopathy of childhood and neurodegeneration with brain iron accululation 5, and has symptoms including convulsion in childhood, seizures, focal and myoclonus, eyelid. An important gene associated with Lennox-Gastaut Syndrome is SCN1A (Sodium Voltage-Gated Channel Alpha Subunit 1), and among its related pathways are Synaptic Neurotransmission Pathways: GABAergic Inhibition and L1CAM interactions. Affiliated tissues include brain, eye and lung, and related mouse phenotypes are reproductive system and growth/size/body region.

Genetics Home Reference:23 Lennox-Gastaut syndrome is a form of severe epilepsy that begins in childhood. It is characterized by multiple types of seizures and intellectual disability.

NIH Rare Diseases:45 Lennox-gastaut syndrome is a form of severe epilepsy that begins in childhood. it is characterized by multiple types of seizures and intellectual disability. this condition can be caused by brain malformations, perinatal asphyxia (lack of oxygen), severe head injury, central nervous system infection and inherited degenerative or metabolic conditions. in about one-third of cases, no cause can be found. treatment for lennox-gastaut syndrome includes anti-epileptic medications such as valproate, lamotrigine, felbamate, or topiramate. there is usually no single antiepileptic medication that will control seizures. children may improve initially, but many later show tolerance to a drug or develop uncontrollable seizures. last updated: 9/17/2013

Related Diseases for Lennox-Gastaut Syndrome

About this section

Diseases related to Lennox-Gastaut Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1acute necrotizing encephalopathy of childhood12.1
2neurodegeneration with brain iron accululation 511.5
3trichorhinophalangeal syndrome, type ii11.3
4encephalopathy10.7
5aseptic meningitis10.6MT-ND1, POMC
6myoclonus cerebellar ataxia deafness10.6SCN1A, SLC2A1
7hemangioma of intra-abdominal structure10.5POMC, TBC1D24
8west syndrome10.5
9copper deficiency, familial benign10.5KCNQ2, SCN1A
10malignant mixed mullerian tumor10.5SCN1A, TBC1D24
11status epilepticus10.4
12myoclonic astatic epilepsy10.4
13phosphorus metabolism disease10.4POMC, SCN1A
14acinar cell cystadenocarcinoma10.4SCN1A, TBC1D24
15cerebritis10.4
16epileptic encephalopathy, early infantile, 1510.3
17cdkl5-related disorder10.3
18olivopontocerebellar atrophy10.3KCNQ2, TBC1D24
19tuberous sclerosis10.3
20hypothalamic hamartomas10.3
21juvenile absence epilepsy10.3KCNQ2, SCN1A, TBC1D24
22smooth muscle tumor10.2POMC, SNRPE
23prothrombin deficiency10.2SCN1A, SLC2A1, TBC1D24
24epilepsy, generalized, with febrile seizures plus, type 510.2GABRA1, SCN1A, TBC1D24
25angelman syndrome10.1
26common variable immunodeficiency10.1
27hepatitis10.1
28hypospadias10.1
29encephalomalacia10.1
30astrocytoma10.1
31acute disseminated encephalomyelitis10.1
32neuronitis10.1
33measles10.1
34tyrosinemia10.1
35intracranial hypertension10.1
36polymicrogyria10.1
37cutis verticis gyrata10.1
38hemimegalencephaly10.1
39pachygyria10.1
40intellectual disability10.1
41cerebral atrophy10.1
42dysphagia10.1
43myoclonus10.1
44eating seizures10.1
45linear nevus sebaceus syndrome10.1
46urethral stricture10.1GABRA1, KCNQ2, SCN1A
47childhood electroclinical syndrome10.1KCNQ2, POMC, SCN1A, TBC1D24
48neurosarcoidosis10.1DCX, EMX2
493-methylcrotonyl-coa carboxylase deficiency10.1AKT3, KCNQ2, SCN1A
50early onset absence epilepsy10.0GABRA1, TBC1D24

Graphical network of the top 20 diseases related to Lennox-Gastaut Syndrome:



Diseases related to lennox-gastaut syndrome

Symptoms for Lennox-Gastaut Syndrome

About this section

UMLS symptoms related to Lennox-Gastaut Syndrome:


convulsion in childhood, seizures, focal, myoclonus, eyelid, seizures, tonic, epileptic aura, seizures, hemiplegia

Drugs & Therapeutics for Lennox-Gastaut Syndrome

About this section

Drugs for Lennox-Gastaut Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Melatoninapproved, nutraceuticalPhase 423473-31-4896
Synonyms:
0E2B08C1-B325-45B1-8939-6F9081EFDFA4
4-ACETAMIDO-4'-ISOTHIO-CYANATOSTILBENE-2,2'-DISULFONIC ACID
5-22-12-00042 (Beilstein Handbook Reference)
5-Methoxy-N-acetyltryptamine
5-methoxy-N-acetyltryptamine
73-31-4
A4039/0172195
AB00053279
AC1L1A9Q
AC1Q4F1W
AC1Q4F1X
AKOS000276269
Acetamide, N-(2-(5-methoxy-1H-indol-3-yl)ethyl)- (9CI)
Acetamide, N-[2-(5-methoxy-1H-indol-3-yl)ethyl]- (9CI)
Acetamide, N-[2-(5-methoxyindol-3-yl)ethyl]- (6CI,8CI)
Acetamide, {N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-}
Acetamide, {N-[2-(5-methoxyindol-3-yl)ethyl]-}
BAS 01281092
BIDD:ER0618
BPBio1_000590
BRD-K97530723-001-07-6
BRN 0205542
BSPBio_000536
BSPBio_003006
Bio-0635
C01598
CAS-73-31-4
CCRIS 3472
CHEBI:16796
CHEMBL45
CID896
ChemDiv2_003916
Circadin
D008550
D08170
DB01065
DB08189
DivK1c_000353
EINECS 200-797-7
EU-0100787
HMS1380B22
HMS1569K18
HMS1921E04
HMS2089F09
HMS501B15
HSCI1_000400
HSDB 7509
I05-0076
I10-0345
IDI1_000353
IDI1_002631
IN1244
KBio1_000353
KBio2_000665
KBio2_003233
KBio2_005801
KBio3_002226
KBioGR_000591
KBioSS_000665
L001261
LS-1623
Lopac-M-5250
Lopac0_000787
M 5250
M-1200
M-1250
M1105
M5250_SIGMA
ML1
MLS000859594
MLS001055382
MLS001240204
MT6
Mela-T
Melapure
Melatol
Melatonex
Melatonex, Melatonin
Melatonin
Melatonin (synth.) standard-grade
 
Melatonin (synth.) ultra-pure
Melatonina
Melatonina (TN)
Melatonine
Melovine
MolPort-000-737-883
N-(2-(5-Methoxy-1H-indol-3-yl)ethyl)acetamide
N-(2-(5-Methoxyindol-3-yl)ethyl)-Acetamide
N-(2-(5-Methoxyindol-3-yl)ethyl)acetamide
N-Acetyl-5-methoxy-tryptamine
N-Acetyl-5-methoxy-tryptamine Melatonine
N-Acetyl-5-methoxytryptamine
N-[2-(5-Methoxy-1H-indol-3-yl)-ethyl]-acetamide
N-[2-(5-Methoxy-1H-indol-3-yl)ethyl)acetamide
N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]-Acetamide
N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]acetamide
N-[2-(5-Methoxyindol-3-yl)ethyl]-Acetamide
N-[2-(5-Methoxyindol-3-yl)ethyl]acetamide
N-[2-(5-methoxyindol-3-yl)ethyl]acetamide
N-acetyl-5-methoxy-tryptamine
NCGC00015680-01
NCGC00015680-02
NCGC00015680-03
NCGC00015680-06
NCGC00015680-13
NCGC00090727-01
NCGC00090727-02
NCGC00090727-03
NCGC00090727-04
NCGC00090727-05
NCGC00090727-06
NCGC00090727-07
NCGC00090727-08
NCGC00090727-09
NCI60_004378
NINDS_000353
NMR/14327425
NSC 113928
NSC113928
NSC56423
Nature'S Harmony
Night Rest
Oprea1_104553
Oprea1_814234
PREVENTION 1 (MELATONIN) (PREVENTION 1)
PREVENTION 2 (MELATONIN)
PREVENTION 3 (MELATONIN)
PREVENTION 4 (MELATONIN)
PREVENTION 5 (MELATONIN)
Pineal Hormone
Posidorm
Prestwick0_000458
Prestwick1_000458
Prestwick2_000458
Prestwick3_000458
Prestwick_312
Regulin
Revital Melatonin
Rx Balance
S1204_Selleck
SDCCGMLS-0065812.P001
SDCCGMLS-0065812.P002
SMP2_000309
SMR000326666
SPBio_001527
SPBio_002475
SPECTRUM1500690
STK386880
Sleep Right
Spectrum2_001344
Spectrum3_001393
Spectrum4_000066
Spectrum5_001745
Spectrum_000185
TNP00300
UNII-JL5DK93RCL
Vivitas
WLN: T56 BMJ D2MV1 GO1
ZINC00057060
{N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-} Acetamide
{N-[2-(5-methoxyindol-3-yl)ethyl]-} Acetamide
2Protective AgentsPhase 4, Phase 3, Phase 15651
3AntioxidantsPhase 42442
4Central Nervous System DepressantsPhase 410016
5
TopiramateapprovedPhase 3, Phase 124097240-79-45284627
Synonyms:
-D-fructopyranose deriv.
.beta.-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, sulfamate (9CI)
2,3-4,5-bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate
2,3:4,5-Bis-O-(1-methylethylidene) .beta.-D-fructopyranose sulfamate
2,3:4,5-Bis-O-(1-methylethylidene)-36-D-fructo-pyranose sulfamate
2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate
2,3:4,5-Di- O -isopropylidene-(beta)-D-fructopyranose sulfamate
2,3:4,5-Di-O-isopropylidene-beta-D-fructopyranose sulfamate
5H-Bis[1,3]dioxolo[4,5-b:4',5'-d]pyran, .beta.
97240-79-4
AKOS000424547
BIDD:GT0854
BIDD:PXR0127
BRN 5988957
BSPBio_002306
C052342
C07502
C12H21NO8S
CBChromo1_000352
CHEBI:129573
CHEMBL220492
CID5284627
CPD000466325
Cilag brand of topiramate
D00537
DB00273
Epitoma
Epitomax
HMS1922H06
HMS2051L09
HMS2093D20
HSDB 7531
Janssen brand of topiramate
KS-1122
KW-6485
LS-187392
LS-69764
MLS000759431
MLS001424070
McN 4853
McN-4853
MolPort-001-615-062
MolPort-002-885-869
NCGC00178714-01
Ortho brand of topiramate
 
Qudexy XR
RWJ 17021
RWJ-17021
RWJ-17021-000
S1438_Selleck
SAM001246601
SMR000466325
SPBio_000995
SPECTRUM1505801
STOCK1N-71037
Spectrum2_001128
T0575_SIGMA
TL8006021
TOR
TPM
Tipiramate
Tipiramate [French]
Tipiramato
Tipiramato [Spanish]
Topamac
Topamax
Topamax (TN)
Topamax Sprinkle
Topamax, Topiramate
Topimax
Topina
Topiramate
Topiramate (JAN/USAN/INN)
Topiramate (TPM)
Topiramate / Placebo
Topiramate [USAN:BAN:INN]
Topiramato
Topiramato [INN-Spanish]
Topiramatum
Topiramatum [INN-Latin]
Topiramic acid
Topomax
Trokendi Xr
UNII-0H73WJJ391
USL-255
[(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate
beta-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, sulfamate
beta.-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, 1-sulfamate
topiramate
topiramate tablet
topiramatum [Latin]
6
Clobazamapproved, illicitPhase 3, Phase 21922316-47-82789
Synonyms:
1-Phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-diketo-3H-1,5-benzodiazepine
1-Phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-dioxo-3H-1, 5-benzodiazepine
1-Phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-dioxo-3H-1,5-benzodiazepine
1-phenyl-5-methyl-8-chloro-1,2,4,5- tetrahydro-2,4-diketo-3H-1,5-benzodiazepine
1-phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-dioxo-3H-1,5-benzodiazepine
22316-47-8
4(3H,5H)-dione
5-24-08-00034 (Beilstein Handbook Reference)
7-Chloro-1-methyl-5-phenyl-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione
7-Chloro-1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,
7-Chloro-1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione
7-Chloro-1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,4-(3H,5H)-dione
7-chloro-1-methyl-5-phenyl-1,5-benzodiazepine-2,4-dione
AC-273
AC1L1EGZ
Ambap22316-47-8
BRN 0758410
C012255
C8414_SIGMA
CCRIS 7506
CHEBI:31413
CHEMBL70418
CID2789
Caastilium
Chlorepin
Clobazam
Clobazam (JAN/USAN/INN)
Clobazam [USAN:BAN:INN]
Clobazamum
 
Clobazamum [INN-Latin]
Clorepin
D01253
DB00349
DEA No. 2751
EINECS 244-908-7
Frisium
H 4723
H-4723
HR 376
LM 2717
LM-2717
LS-34098
MolPort-003-940-848
Mystan
Mystan (TN)
NCGC00168249-01
NSC 336279
NSC336279
Noiafren
Odipam
Onfi
RU-4723
UNII-2MRO291B4U
Urbadan
Urbanil
Urbanyl
WLN: T67 GNV JVN IHJ CG G1 KR
ZINC00001175
clobazam
nchembio747-comp39
7
BenzocaineapprovedPhase 316841994-09-7, 94-09-72337
Synonyms:
(p-(Ethoxycarbonyl)phenylamine
06952_FLUKA
112909_ALDRICH
112909_SIAL
1333-08-0
20/20 Topical Anesthetic
23239-88-5
23239-88-5 (hydrochloride)
4 Aminobenzoic Acid Ethyl Ester
4-(Ethoxycarbonyl)aniline
4-(Ethoxycarbonyl)phenylamine
4-14-00-01129 (Beilstein Handbook Reference)
4-Aminobenzoate
4-Aminobenzoic acid
4-Aminobenzoic acid ethyl ester
4-Aminobenzoic acid, ethyl ester
4-Carbethoxyaniline
4-amino-benzoic acid ethyl ester
4-aminobenzoic acid ethyl ester
71123-91-6
94-09-7
94-09-7 (Parent)
A0271
AB00051923
AC1L1DGC
AC1Q341A
AC1Q64JE
AE-562/40377256
AI3-02081
AKOS000119763
AR-1H9065
Acetate, Benzocaine
Aethoform
Aethylium paraminobenzoicum
Alcohol Prep Pads
Allegenal-m
Alpha-caine Topical Anesthetic
Amben ethyl ester
Americaine
Anaesthan-syngala
Anaesthesin
Anaesthesinum
Anaesthin
Anbesol Jr
Anbesol Maximum Strength
Anbesol Regular Strength
Anestenka
Anestezin
Anestezin [Russian]
Anesthesin
Anesthesine
Anesthetic
Anesthone
Atopalm Oral Pain Relief
BB_SC-0019
BPBio1_001017
BRD-K75466013-001-05-2
BRN 0638434
BSPBio_000923
BSPBio_001908
Baby Anbesol
Baby Anestenka
Baby Sensigel
Baby Sensigel Night Time Formula
Baby Teething Oral Pain Reliever
Bactimicina For Sore Throat
Bencocaine Topical Anesthetic
Bensokain
Benz O Sthetic
Benzoak
Benzocaina
Benzocaina [INN-Spanish]
Benzocaine
Benzocaine (USP/INN)
Benzocaine Acetate
Benzocaine Formate
Benzocaine Hydrobromide
Benzocaine Hydrochloride
Benzocaine Methanesulfonate
Benzocaine [INN:BAN]
Benzocainum
Benzocainum [INN-Latin]
Benzodent
Benzoic acid, 4-amino-, ethyl ester
Benzoic acid, 4-amino-, ethyl ester, hydrochloride
Benzoic acid, amino-, ethyl ester
Benzoic acid, p-amino-, ethyl ester
Boil Ease
Boy Butter Desensitizing Lubricant
Boy Butter Extreme Desensitizing Lubricant
Boy Butter Extreme H2O Desensitizing Lubricant
Brace Relief
Budpak Baby Teething Oral Pain Reliever
Budpak Oral Maximum Strength
C07527
CAS-94-09-7
CHEBI:116735
CHEMBL278172
CID2337
Carmex Cold Sore Treatment External Analgesic
Caswell No. 430A
Cepacol Fizzlers
Cepacol Sensations Hydra
Cepacol Sensations Sore Throat Hydra citrus splash
Cepacol Sensations Warming
Certus Sting Relief Prep Pad
Chloraseptic
Chloraseptic Warming Sore Throat
Colgate Orabase
Comfortcaine Topical Anesthetic
Cvs Fast Acting Baby Teething
Cvs Maximum Strength
Cvs Maximum Strength Boil Relief
Cvs Oral Anesthetic
Cvs Pharmacy Instant Toothache
Cvs Pharmacy Maximum Strength
Cvs Pharmacy Mouth Sore Gel
Cvs Pharmacy Nighttime Oral Pain Relief
D001566
D00552
DB01086
Dental Relief
Dentek Instant Pain Relief Maximum Strength
Dermoplast
Diet Ayds
DivK1c_000932
Dollar General Toothache Relief
Dukal Sting Relief Pad
E1501_SIGMA
EINECS 202-303-5
EPA Pesticide Chemical Code 097001
ETHYL-P-AMINOBENZOATE
Ethoform
Ethoforme
Ethyl 4-aminobenzoate
Ethyl 4-aminobenzoate hydrochloride
Ethyl 4-aminobenzoic acid
Ethyl Aminobenzoate
Ethyl PABA
Ethyl aminobenzoate
Ethyl aminobenzoate (JP15)
Ethyl aminobenzoate (VAN)
Ethyl aminobenzoic acid
Ethyl p-Aminobenzoate
Ethyl p-Aminophenylcarboxylate
Ethyl p-aminobenzenecarboxylate
Ethyl p-aminobenzoate
Ethyl p-aminobenzoic acid
Ethyl p-aminophenylcarboxylate
Ethylester kyseliny p-aminobenzoove
Ethylester kyseliny p-aminobenzoove [Czech]
Ethylis aminobenzoas
Finafta Baby
Finafta MultiOral
Formate, Benzocaine
Gelato Topical Anesthetic
Good Neighbor Pain Relief
Goodsense Oral Pain Relief
Gps Topical Anesthetic
Gumnumb Topical Anesthetic
HMS1570O05
HMS1920G09
HMS2091M11
HMS502O14
HSDB 7225
Heb Severe Toothache
Herbasoul Male Genital Desensitizer Cream
 
Hurricaine
Hurricaine Topical Anesthetic
Hurricaine Topical Anesthetic Gel
Hurricaine Topical Anesthetic Liquid
Hydrobromide, Benzocaine
Hydrochloride, Benzocaine
I05-0204
IDI1_000932
Identhesin
Insect Bite Relief
Instant Toothache Pain Relief
Intense Cvs Intense Toothache
Iodent Maximum Strength Oral Analgesic
Ismile Topical Anesthetic
Jianze Sting Relief Pads
KBio1_000932
KBio2_000474
KBio2_003042
KBio2_005610
KBio3_001408
KBioGR_000658
KBioSS_000474
Kank-a Mouth Pain
Keloform
Kmart Smart Sense
Kroger Toothache Pain Relief
LS-35847
Leader Oral Analgesic
Little Colds Sore Throat Relief Melt Aways
MLS001331704
MLS002153970
Makesense Junior Pain Relief
Makesense Pain Relief
Male Desensitizer Pleasure Balm
Mandelay Male Genital Desensitizer
Mark 3
Methanesulfonate, Benzocaine
MolPort-000-871-526
Mouth Sore Medication
Mouth Sore Relief Applicator
Mouth Sore Relief Professional Strength
My Fair Baby Instant Pain Relief
NCGC00016352-01
NCGC00094598-01
NCGC00094598-02
NINDS_000932
NSC 122792
NSC 41531
NSC41531
NSC4688
Nene Dente
Norcain
Norcaine
Norcainum
Opahl
Opahl Dye Free
Oprea1_750694
Oprea1_827402
Ora-jel
Orabase-B
Orajel For All Mouth Sores Maximum Strength
Orajel For Cold Sores
Orajel For Toothache Maximum Strength
Orajel Instant Pain Relief Maximum Strength
Orajel Instant Pain Relief Regular Strength
Orajel Instant Relief For Teething Pain
Orajel Instant Relief For Teething Pain Cooling Cucumber
Orajel Instant Relief For Teething Pain Daytime Nighttime Twin Pack
Orajel Instant Relief For Teething Pain Longer Lasting
Orajel Maximum Strength
Orajel Nighttime Instant Relief For Teething Pain Longer Lasting Extra Strength
Orajel Severe Toothache Maximum Strength Fast-Acting Formula
Oral Analgesic Maximum Strength
Oral B Instant Pain Relief
Oral Gel Maximum Strength
Oral Pain Relief Anesthetic Anesthetic
Oral Pain Reliever
Oralabs Cold Sore Treatment
Orthesin
Otocain
Outgro
Pac-dent Top Gel
Pain Relief
Pain Relief Alcohol Swabs
Parathesin
Parathesin (TN)
Parathesine
Physicians Care Sting Relief Pad
Pleasure Balm Kama Sutra
Preboost
Prestwick0_000712
Prestwick1_000712
Prestwick2_000712
Prestwick3_000712
Prestwick_991
Purelife Topical Anesthetic
Quality Choice Maximum Strength Oral Pain Relieving
Red Cross Oral Pain Relief
Rexall Maximum Strength
Rite Aid Baby Care
Rite Aid Liquid Anesthetic Oral Pain Relief
Rite Aid Maximum Strength
Rite Aid Oral Pain Reliever
Rite Aid Professional Strength
SMR000059025
SPBio_000134
SPBio_002844
SPECTRUM1500139
STK043620
Sally Hansen Ouch-relief Numbing Wipes
Sally Hansen Ouch-relief Wax Kit
Sally Hansen Ouch-relief Wax Strip Kit
Sensigel
Severe Oral Pain Reliever
Sheffield Baby Teething Gel
Sheffield Pain Relief
Shunga Male Genital Desensitizer
Slim Mint Gum
Solarcaine
Solu H
Spectrum2_000117
Spectrum3_000314
Spectrum4_000249
Spectrum5_000860
Spectrum_000074
Sting Relief Medicated Pad
Sting Relief Pads
Tanac
Terrasil Boil Pain Relief
Tiger Supply Inc Topical Anesthetic
Top Quality Mfg. Topical Anesthetic
Topcaine
Topcare Maximum Strength
Topical Anesthetic Banana
Topical Anesthetic Bubble Gum
Topical Anesthetic Cherry
Topical Anesthetic Mint
Topical Anesthetic Pina Colada
Topical Anesthetic Raspberry
Topical Anesthetic Strawberry
UNII-U3RSY48JW5
Ultracare Anesthetic Bubble Gum
Ultracare Anesthetic Butter Rum
Ultracare Anesthetic Creme de Menthe
Ultracare Anesthetic Pina Colada
Ultracare Anesthetic Walterberry
WLN: ZR DVO2
Walgreens Baby Teething
Walgreens Intense Toothache
Walgreens Maximum Strength
Walgreens Pain Relieving For Boils
Walgreens Severe Oral Pain Reliever
Walgreens Severe Toothache Relief
Winco Foods Maximum Strength Oral Analgesic
ZINC12358719
Zilactin-b
benzocaine
ethylaminobenzoate-4
h-4-abz-oet
nchembio.182-comp4
p-(Ethoxycarbonyl)aniline
p-Aminobenzoate
p-Aminobenzoic acid
p-Aminobenzoic acid ethyl ester
p-Aminobenzoic acid, ethyl ester
p-Aminobenzoic ethyl ester
p-Carbethoxyaniline
p-Ethoxycarboxylic Aniline
p-Ethoxycarboxylic aniline
8
EzogabineapprovedPhase 3, Phase 227150812-12-7121892
Synonyms:
150812-12-7
AC-6908
AC1L3TLD
ADD-230001
C101866
C13826
C16H18FN3O2
CHEBI:161945
CHEMBL41355
CID121892
Carbamic acid, (2-amino-4-(((4-fluorophenyl)methyl)amino)phenyl)-, ethyl ester
D 20443
D 23129
D-20443
D-23129
EZG
Ethyl (2-amino-4-(((4-fluorophenyl)methyl)amino)phenyl)carbamate
Ethyl 2-amino-4-((P-fluorobenzyl)amino)carbanilate
Ethyl 2-amino-4-((p-fluorobenzyl)amino)carbanilate
Ethyl {2-amino-4-[(4-fluorobenzyl)amino]phenyl}carbamate
 
Ezogabine
FT-0080801
GKE-841
I06-0810
KE-0201
LS-48932
MolPort-003-850-148
N-(2-Amino-4-(4-fluorobenzylamino)-phenyl) carbamic acid ethyl ester
N-(2-Amino-4-(4-fluorobenzylamino)phenyl)carbamic acid ethyl ester
Potiga
RTG
Retigabine
Retigabine [USAN]
TL80090034
Trobalt
UNII-12G01I6BBU
ZINC00016154
[2-Amino-4-[[(4-fluorophenyl)methyl]amino]phenyl]-carbamate
ethyl N-(2-amino-4-(4-fluorobenzylamino)phenyl)carbamate hydrochloride
ethyl N-[2-amino-4-[(4-fluorophenyl)methylamino]phenyl]carbamate
nchembio874-comp3
9AnticonvulsantsPhase 3, Phase 2, Phase 12249
10Neuroprotective AgentsPhase 3, Phase 11376
11Anti-Obesity AgentsPhase 3, Phase 1354
12ListerinePhase 3164
13sodium fluoridePhase 3164
14Pharmaceutical SolutionsPhase 37004
15Phase 3
16tannic acidNutraceuticalPhase 31684
17StrawberryNutraceuticalPhase 375
18Neurotransmitter AgentsPhase 214795
19Serotonin AgentsPhase 22668
20Serotonin Uptake InhibitorsPhase 21369
21
SerotoninPhase 2314750-67-95202
Synonyms:
3-(2-Aminoethyl)-1H-indol-5-ol
3-(2-Aminoethyl)indol-5-ol
3-(b-Aminoethyl)-5-hydroxyindole
5-HT
5-HTA
5-Hydroxy-3-(b-aminoethyl)indole
 
5-Hydroxy-tryptamine
5-Hydroxyltryptamine
5-Hydroxytriptamine
5-Hydroxytryptamine
Antemovis
DS substance
Enteramin
Enteramine
22Neurotransmitter Uptake InhibitorsPhase 22857
23
Lamotrigineapproved, investigational17984057-84-13878
Synonyms:
3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine
3,5-Diamino-6-(2,3-dichlorophenyl)-as-triazine
3,5-diamino-6-(2,3-dichlorophenyl)- as -triazine
6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diyldiamine
6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine
84057-84-1
AC-10298
AC1L1GWT
BIDD:GT0794
BW 430C
BW-430C
Bio-0056
C047781
CHEBI:138727
CHEBI:6367
CHEMBL741
CID3878
CPD000058464
Crisomet
D00354
DB00555
Desitin Brand of Lamotrigine
EINECS 281-901-8
EU-0100688
EUR-1048
Faes Brand of Lamotrigine
GI 267119X
GW 273293
Glaxo Wellcome Brand of Lamotrigine
GlaxoSmithKline Brand of Lamotrigine
HMS2051C10
HMS2089M08
HMS2093P21
HSDB 7526
Juste Brand of Lamotrigine
L 3791
L3791_SIGMA
LS-155249
 
Labileno
Lamictal
Lamictal (TN)
Lamictal CD
Lamictal Cd
Lamictal ODT
Lamictal XR
Lamictin
Lamiktal
Lamitor
Lamotrigina
Lamotrigina [Spanish]
Lamotrigine
Lamotrigine (JAN/USAN/INN)
Lamotrigine [USAN:INN:BAN]
Lamotriginum
Lamotriginum [Latin]
Lopac-L-3791
Lopac0_000688
MLS000069685
MLS000759486
MLS001077325
MolPort-003-666-744
NCGC00015605-01
NCGC00015605-02
NCGC00015605-06
NCGC00015605-08
NCGC00022936-02
NCGC00022936-04
NCGC00022936-05
NSC746307
SAM001246697
SMP2_000303
SMR000058464
STK628377
Tocris-1611
UNII-U3H27498KS
ZINC00013156
lamotrigine
24Fluorodeoxyglucose F18356
25Excitatory Amino Acids1109
26Sodium Channel Blockers1180
27Calcium, Dietary4678
28calcium channel blockers1743
29Diuretics, Potassium Sparing1445
30Excitatory Amino Acid Antagonists1095

Interventional clinical trials:

(show all 28)
idNameStatusNCT IDPhase
1Transcranial Direct Current Stimulation, Treatment of Childhood Drug-Resistant Lennox-Gastaut Syndrome, A Pilot StudyCompletedNCT02731300Phase 4
2Melatonin Versus Placebo in the Lennox-Gastaut Syndrome: Neurophysiological and Neuropsychological EffectsNot yet recruitingNCT01370486Phase 4
3Safety and Effectiveness of Open-Label Clobazam in Subjects With Lennox-Gastaut SyndromeCompletedNCT01160770Phase 3
4A Placebo-Controlled, Double-Blind Comparative Study of E2080 in Lennox-Gastaut Syndrome Patients (Study E2080-J081-304)CompletedNCT01146951Phase 3
5Study of Rufinamide in Pediatric Subjects 1 to Less Than 4 Years of Age With Lennox-Gastaut Syndrome Inadequately Controlled With Other Anti-epileptic DrugsCompletedNCT01405053Phase 3
6Phase III Randomized, Double-Blind, Placebo-Controlled Study of Oral Topiramate for Lennox-Gastaut SyndromeCompletedNCT00004776Phase 3
7Clobazam in Patients With Lennox-Gastaut SyndromeCompletedNCT00518713Phase 3
8A Study of the Efficacy and Safety of Topiramate as an add-on Therapy in the Treatment of Epilepsy Patients With Lennox-Gastaut SyndromeCompletedNCT00236756Phase 3
9A Long Term Extension Study of E2080 in Lennox-Gastaut PatientsCompletedNCT01151540Phase 3
10Study to Determine the Efficacy and Safety of Adjunctive Topiramate in the Treatment of Obsessive-Compulsive DisorderCompletedNCT00187928Phase 3
11A Study to Investigate the Efficacy and Safety of Cannabidiol (GWP42003-P; CBD) as Adjunctive Treatment for Seizures Associated With Lennox-Gastaut Syndrome in Children and AdultsActive, not recruitingNCT02224690Phase 3
12A Study to Investigate the Efficacy and Safety of Cannabidiol (GWP42003-P; CBD) as Adjunctive Treatment for Seizures Associated With Lennox-Gastaut Syndrome in Children and AdultsActive, not recruitingNCT02224560Phase 3
13An Open Label Extension Study of Cannabidiol (GWP42003-P) in Children and Young Adults With Dravet or Lennox-Gastaut SyndromesEnrolling by invitationNCT02224573Phase 3
14Cannabidiol Oral Solution as an Adjunctive Treatment for Treatment-resistant Seizure DisorderEnrolling by invitationNCT02318602Phase 3
15Cannabidiol Oral Solution as an Adjunctive Therapy for Treatment of Subjects With Inadequately Controlled Lennox-Gastaut SyndromeNot yet recruitingNCT02318537Phase 3
16Long-term, Open-label Safety Extension Study of Retigabine/Ezogabine in Pediatric Subjects (>= 12 Years Old) With POS or LGSTerminatedNCT01668654Phase 3
17Clobazam in Subjects With Lennox-Gastaut SyndromeCompletedNCT00162981Phase 2
18Add-on Therapy With Low Dose Fenfluramine in Lennox Gastaut EpilepsyNot yet recruitingNCT02655198Phase 2
19Study in Pediatric Subjects With EpilepsyTerminatedNCT01494584Phase 2
20A Study of the Pharmacokinetics, Safety and Tolerability of Topiramate in Infants (Age 1-24 Months) With Refractory Partial-onset SeizuresCompletedNCT00233012Phase 1
21European Registry of Anti-Epileptic Drug Use in Patients With Lennox-Gastaut Syndrome (LGS)CompletedNCT01991041
22Ketogenic Diet for Child Epilepsy and Seizure ControlCompletedNCT00004729
23A Study of the Safety of Topiramate Given in Combination With Other Medications in Adults and Children With SeizuresCompletedNCT00297349
24Metabolic Abnormalities in Children With EpilepsyCompletedNCT00001325
25Trial to Assess Vagus Nerve Stimulation Therapy in Children With Lennox-Gastaut SyndromeRecruitingNCT02632149Phase 0
26Post-marketing Surveillance of Long-term Administration of Inovelon Tablets in Patients With Lennox-Gastaut SyndromeRecruitingNCT02175173
27Epilepsy Phenome/Genome ProjectActive, not recruitingNCT00552045
28Special Drug Use Investigation for LAMICTAL® (Long Term)Active, not recruitingNCT01863602

Search NIH Clinical Center for Lennox-Gastaut Syndrome

Genetic Tests for Lennox-Gastaut Syndrome

About this section

Genetic tests related to Lennox-Gastaut Syndrome:

id Genetic test Affiliating Genes
1 Epileptic Encephalopathy, Lennox-Gastaut Type22 MAPK10

Anatomical Context for Lennox-Gastaut Syndrome

About this section

MalaCards organs/tissues related to Lennox-Gastaut Syndrome:

33
Brain, Eye, Lung, B cells, Thyroid, Liver, T cells

Animal Models for Lennox-Gastaut Syndrome or affiliated genes

About this section

MGI Mouse Phenotypes related to Lennox-Gastaut Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053897.8AKT3, CHD2, DCX, EMX2, GABRA1, GRM5
2MP:00053787.0AKT3, CHD2, DCX, EMX2, GABRA1, GRM5
3MP:00036316.7AKT3, DCX, DNM1, EMX2, GABRA1, GRM5
4MP:00053866.7AKT3, CHD2, DCX, DNM1, EMX2, GABRA1

Publications for Lennox-Gastaut Syndrome

About this section

Articles related to Lennox-Gastaut Syndrome:

(show top 50)    (show all 292)
idTitleAuthorsYear
1
Clobazam-treated patients with Lennox-Gastaut syndrome experienced fewer seizure-related injuries than placebo patients during trial OV-1012. (27145465)
2016
2
Long-term safety and seizure outcome in Japanese patients with Lennox-Gastaut syndrome receiving adjunctive rufinamide therapy: An open-label study following a randomized clinical trial. (26827266)
2016
3
Management of difficult airway with inhalation induction in a patient with Lennox-Gastaut syndrome and neck injury. (25687944)
2015
4
Comprehensive overview: efficacy, tolerability, and cost-effectiveness of clobazam in Lennox-Gastaut syndrome. (26089675)
2015
5
In response: Lennox-Gastaut syndrome may be a curable, reversible epileptic encephalopathy. (25778756)
2015
6
Lennox-Gastaut syndrome: impact on the caregivers and families of patients. (25336963)
2014
7
Anterior corpus callosotomy in school-aged children with Lennox-Gastaut syndrome: A prospective study. (24912732)
2014
8
Adjunctive levetiracetam treatment in pediatric Lennox-Gastaut syndrome. (25266616)
2014
9
Conceptualizing lennox-gastaut syndrome as a secondary network epilepsy. (25400619)
2014
10
Efficacy and tolerability of add-on Lacosamide in children with Lennox-Gastaut syndrome. (25052288)
2014
11
Withdrawal-related adverse events from clinical trials of clobazam in Lennox-Gastaut syndrome. (24949576)
2014
12
Glycemic index treatment using Japanese foods in a girl with Lennox-Gastaut syndrome. (23583057)
2013
13
Tonic seizures of Lennox-Gastaut syndrome: Periictal single-photon emission computed tomography suggests a corticopontine network. (24117046)
2013
14
Whole-exome sequencing identifies a variant of the mitochondrial MT-ND1 gene associated with epileptic encephalopathy: west syndrome evolving to Lennox-Gastaut syndrome. (24105702)
2013
15
Lennox-Gastaut syndrome in south Iran: electro-clinical manifestations. (22921514)
2012
16
Efficacy of the ketogenic diet in Lennox-Gastaut syndrome: a retrospective review of one institution's experience and summary of the literature. (22443637)
2012
17
Update on the management of Lennox-Gastaut syndrome. (22883278)
2012
18
Rufinamide as an adjuvant treatment in children with Lennox-Gastaut syndrome. (22421185)
2012
19
Clobazam : in patients with Lennox-Gastaut syndrome. (23034582)
2012
20
Post-section recruitment of epileptiform discharges in electrocorticography during callosotomy in 48 patients with Lennox-Gastaut syndrome. (22281384)
2012
21
Long-term safety and efficacy of clobazam for Lennox-Gastaut syndrome: interim results of an open-label extension study. (23141144)
2012
22
Management of seizures in Lennox-Gastaut syndrome. (21351810)
2011
23
Localization of ictal onset zones in Lennox-Gastaut syndrome using directed transfer function method. (22255466)
2011
24
Increased risk of death among children with Lennox-Gastaut syndrome and infantile spasms. (20023065)
2010
25
Medical management of Lennox-Gastaut syndrome. (20158289)
2010
26
Does lacosamide aggravate Lennox-Gastaut syndrome? Report on three consecutive cases. (20970386)
2010
27
SCN1A mutation screening in adult patients with Lennox-Gastaut syndrome features. (19782004)
2009
28
Treatment of Lennox-Gastaut Syndrome (LGS). (19211283)
2009
29
Lennox-Gastaut syndrome: a consensus approach on diagnosis, assessment, management, and trial methodology. (19081517)
2009
30
Delayed response of seizures with vagus nerve stimulation in Lennox-Gastaut syndrome. (15505192)
2004
31
Nitrazepam for the treatment of Lennox-Gastaut syndrome. (12657414)
2003
32
Correction to infantile spasms and Lennox-Gastaut syndrome. (12822828)
2003
33
Temporo-spatial correlations between scalp and centromedian thalamic EEG activities of stage II slow wave sleep in patients with generalized seizures of the cryptogenic Lennox-Gastaut syndrome. (11801421)
2002
34
Drug therapy in Lennox-Gastaut syndrome. (11993742)
2002
35
Eating seizures in Lennox-Gastaut syndrome. (11244278)
2001
36
Cutis verticis gyrata, mental retardation and Lennox-Gastaut syndrome: a case report. (11731879)
2001
37
Long-term seizure outcome in 74 patients with Lennox-Gastaut syndrome: effects of incorporating MRI head imaging in defining the cryptogenic subgroup. (10756403)
2000
38
Vagus nerve stimulation treatment for Lennox-Gastaut syndrome. (10961788)
2000
39
Lennox-Gastaut syndrome. (9390695)
1997
40
Temporo-spacial correlations between cortical and subcortical EEG spike-wave complexes of the Idiopathic Lennox-Gastaut syndrome. (9711757)
1997
41
Case study. A child with Lennox-Gastaut syndrome. (8788700)
1996
42
Evolution of Lennox-Gastaut syndrome: a long-term longitudinal study. (8681913)
1996
43
Multifocal independent Spike syndrome: relationship to hypsarrhythmia and the slow spike-wave (Lennox-Gastaut) syndrome. (7882540)
1995
44
Lennox-Gastaut syndrome--clinical seizure outcome and social prognosis. (2124295)
1990
45
Depth EEG studies in the Lennox-Gastaut syndrome. (3117442)
1987
46
Lennox-gastaut syndrome with and without Dandy-Walker malformation. (3504401)
1987
47
West syndrome evolving into the Lennox-Gastaut syndrome. (6697547)
1984
48
Secondary late-onset Lennox-Gastaut syndrome: a critical view. (6466153)
1984
49
50

Variations for Lennox-Gastaut Syndrome

About this section

Clinvar genetic disease variations for Lennox-Gastaut Syndrome:

5
id Gene Variation Type Significance SNP ID Assembly Location
1NM_006920.4(SCN1A): c.4874G> A (p.Arg1625Gln)single nucleotide variantLikely pathogenic, Pathogenicrs121917995GRCh37Chr 2, 166848878: 166848878

Expression for genes affiliated with Lennox-Gastaut Syndrome

About this section
Search GEO for disease gene expression data for Lennox-Gastaut Syndrome.

Pathways for genes affiliated with Lennox-Gastaut Syndrome

About this section

GO Terms for genes affiliated with Lennox-Gastaut Syndrome

About this section

Biological processes related to Lennox-Gastaut Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ion transportGO:00068119.5GABRA1, KCNQ2, SCN1A

Sources for Lennox-Gastaut Syndrome

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet