MCID: LNN001
MIFTS: 54

Lennox-Gastaut Syndrome malady

Categories: Genetic diseases, Rare diseases, Neuronal diseases, Blood diseases

Aliases & Classifications for Lennox-Gastaut Syndrome

About this section
Sources:
11Disease Ontology, 12diseasecard, 13DISEASES, 24GeneTests, 25Genetics Home Reference, 27GTR, 31ICD10 via Orphanet, 40MESH via Orphanet, 48NIH Rare Diseases, 49NINDS, 50Novoseek, 54Orphanet, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Lennox-Gastaut Syndrome:

Name: Lennox-Gastaut Syndrome 11 48 25 49 54 50 13 68
Epileptic Encephalopathy, Lennox-Gastaut Type 24 27 12
Lennox Syndrome 11 68
Childhood Epileptic Encephalopathy with Diffuse Slow Spikes and Waves 25
 
Epileptic Encephalopathy Lennox-Gastaut Type 48
Encephalopathy of Childhood 48
Lgs 25

Characteristics:

Orphanet epidemiological data:

54
lennox-gastaut syndrome:
Inheritance: Autosomal dominant,Multigenic/multifactorial,Not applicable; Prevalence: 1-9/1000000 (Europe),1-5/10000 (Europe); Age of onset: Childhood

Classifications:



External Ids:

Disease Ontology11 DOID:0050561
Orphanet54 ORPHA2382
UMLS via Orphanet69 C0238111
MESH via Orphanet40 C535500
ICD10 via Orphanet31 G40.4

Summaries for Lennox-Gastaut Syndrome

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NINDS:49 Lennox-Gastaut syndrome is a severe form of epilepsy. Seizures usually begin before 4 years of age. Seizure types, which vary among patients, include tonic (stiffening of the body, upward deviation of the eyes, dilation of the pupils, and altered respiratory patterns), atonic (brief loss of muscle tone and consciousness, causing abrupt falls), atypical absence (staring spells), and myoclonic (sudden muscle jerks). There may be periods of frequent seizures mixed with brief, relatively seizure-free periods. Most children with Lennox-Gastaut syndrome experience some degree of impaired intellectual functioning or information processing, along with developmental delays, and behavioral disturbances. Lennox-Gastaut syndrome can be caused by brain malformations, perinatal asphyxia, severe head injury, central nervous system infection and inherited degenerative or metabolic conditions. In 30-35 percent of cases, no cause can be found.

MalaCards based summary: Lennox-Gastaut Syndrome, also known as epileptic encephalopathy, lennox-gastaut type, is related to neurodegeneration with brain iron accululation 5 and epileptic encephalopathy, early infantile, 15, and has symptoms including hemiplegia, seizures and epileptic aura. An important gene associated with Lennox-Gastaut Syndrome is SCN1A (Sodium Voltage-Gated Channel Alpha Subunit 1), and among its related pathways are L1CAM interactions and Adipocytokine signaling pathway. Affiliated tissues include brain, eye and cortex, and related mouse phenotypes are growth/size/body region and mortality/aging.

Genetics Home Reference:25 Lennox-Gastaut syndrome is a form of severe epilepsy that begins in childhood. It is characterized by multiple types of seizures and intellectual disability.

NIH Rare Diseases:48 Lennox-Gastaut syndrome is a form of severe epilepsy that begins in childhood. It is characterized by multiple types of seizures and intellectual disability. This condition can be caused by brain malformations, perinatal asphyxia (lack of oxygen), severe head injury, central nervous system infection and inherited degenerative or metabolic conditions. In about one-third of cases, no cause can be found. Treatment for Lennox-Gastaut syndrome includes anti-epileptic medications such as valproate, lamotrigine, felbamate, or topiramate. There is usually no single antiepileptic medication that will control seizures. Children may improve initially, but many later show tolerance to a drug or develop uncontrollable seizures. Last updated: 9/17/2013

Related Diseases for Lennox-Gastaut Syndrome

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Diseases related to Lennox-Gastaut Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 58)
idRelated DiseaseScoreTop Affiliating Genes
1neurodegeneration with brain iron accululation 511.6
2epileptic encephalopathy, early infantile, 1511.2
3trichorhinophalangeal syndrome, type ii11.2
4encephalopathy, acute, infection-induced, 410.8
5epilepsy10.7
6encephalopathy10.5
7peripheral retinal degeneration10.5MT-ND1, POMC
8double fingernail of fifth finger10.5SCN1A, SLC2A1
9extratemporal epilepsy10.4POMC, TBC1D24
10west syndrome10.3
11urethral obstruction sequence10.3SCN1A, TBC1D24
12status epilepticus10.3
13myoclonic astatic epilepsy10.3
14active vestibular meniere's disease10.3GABRB3, POMC
15cerebritis10.2
16blount's disease10.2KCNQ2, TBC1D24
17epidermolysis bullosa acquisita10.2POMC, SNRPE
18idiopathic hemiconvulsion-hemiplegia syndrome10.2GABRG2, SCN1A
19erb-duchenne and dejerine-klumpke palsies10.2DNM1, KCNQ2, SCN1A
20neonatal infective mastitis10.2AKT3, DCX, POMC
21hypothalamic hamartomas10.1
22aceruloplasminemia10.1AKT3, KCNQ2, SCN1A
23childhood malignant hemangiopericytoma10.1SCN1A, TBC1D24
24peyronie's disease10.0KCNQ2, MT-ND1, POMC, ST3GAL3, TBC1D24
25angelman syndrome10.0
26common variable immunodeficiency10.0
27hepatitis10.0
28hypospadias10.0
29encephalomalacia10.0
30focal epilepsy10.0
31astrocytoma10.0
32acute disseminated encephalomyelitis10.0
33neuronitis10.0
34measles10.0
35tyrosinemia10.0
36intracranial hypertension10.0
37polymicrogyria10.0
38cutis verticis gyrata10.0
39hemimegalencephaly10.0
40pachygyria10.0
41intellectual disability10.0
42cerebral atrophy10.0
43dysphagia10.0
44myoclonus10.0
45eating seizures10.0
46epilepsy, juvenile absence 110.0GABRA1, GABRG2, SCN1A
47childhood electroclinical syndrome9.9KCNQ2, SCN1A, SNRPE, TBC1D24
48interstitial lung disease9.9KCNQ2, SCN1A, SNRPE, TBC1D24
49granulomatous hepatitis9.8GABRG2, SCN1A, SLC2A1, TBC1D24
50adolescence-adult electroclinical syndrome9.7GABRG2, KCNQ2, POMC, SCN1A, TBC1D24

Graphical network of the top 20 diseases related to Lennox-Gastaut Syndrome:



Diseases related to lennox-gastaut syndrome

Symptoms & Phenotypes for Lennox-Gastaut Syndrome

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UMLS symptoms related to Lennox-Gastaut Syndrome:


hemiplegia, seizures, epileptic aura, seizures, tonic, myoclonus, eyelid, seizures, focal, convulsion in childhood

MGI Mouse Phenotypes related to Lennox-Gastaut Syndrome according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053788.2AKT3, CHD2, DCX, GABRA1, GABRB3, GABRG2
2MP:00107688.0AKT3, CHD2, DCX, DNM1, GABRA1, GABRB3
3MP:00053897.9AKT3, CHD2, DCX, GABRA1, GABRB3, GABRG2
4MP:00036317.3ADGRG1, AKT3, DCX, DNM1, GABRA1, GABRB2
5MP:00053866.9ADGRG1, AKT3, CHD2, DCX, DNM1, GABRA1

Drugs & Therapeutics for Lennox-Gastaut Syndrome

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Drugs for Lennox-Gastaut Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Melatoninapproved, nutraceutical, vet_approvedPhase 425573-31-4896
Synonyms:
0E2B08C1-B325-45B1-8939-6F9081EFDFA4
4-ACETAMIDO-4'-ISOTHIO-CYANATOSTILBENE-2,2'-DISULFONIC ACID
5-22-12-00042 (Beilstein Handbook Reference)
5-Methoxy-N-acetyltryptamine
5-methoxy-N-acetyltryptamine
73-31-4
A4039/0172195
AB00053279
AC1L1A9Q
AC1Q4F1W
AC1Q4F1X
AKOS000276269
Acetamide, N-(2-(5-methoxy-1H-indol-3-yl)ethyl)- (9CI)
Acetamide, N-[2-(5-methoxy-1H-indol-3-yl)ethyl]- (9CI)
Acetamide, N-[2-(5-methoxyindol-3-yl)ethyl]- (6CI,8CI)
Acetamide, {N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-}
Acetamide, {N-[2-(5-methoxyindol-3-yl)ethyl]-}
BAS 01281092
BIDD:ER0618
BPBio1_000590
BRD-K97530723-001-07-6
BRN 0205542
BSPBio_000536
BSPBio_003006
Bio-0635
C01598
CAS-73-31-4
CCRIS 3472
CHEBI:16796
CHEMBL45
CID896
ChemDiv2_003916
Circadin
D008550
D08170
DB01065
DB08189
DivK1c_000353
EINECS 200-797-7
EU-0100787
HMS1380B22
HMS1569K18
HMS1921E04
HMS2089F09
HMS501B15
HSCI1_000400
HSDB 7509
I05-0076
I10-0345
IDI1_000353
IDI1_002631
IN1244
KBio1_000353
KBio2_000665
KBio2_003233
KBio2_005801
KBio3_002226
KBioGR_000591
KBioSS_000665
L001261
LS-1623
Lopac-M-5250
Lopac0_000787
M 5250
M-1200
M-1250
M1105
M5250_SIGMA
ML1
MLS000859594
MLS001055382
MLS001240204
MT6
Mela-T
Melapure
Melatol
Melatonex
Melatonex, Melatonin
Melatonin
Melatonin (synth.) standard-grade
 
Melatonin (synth.) ultra-pure
Melatonina
Melatonina (TN)
Melatonine
Melovine
MolPort-000-737-883
N-(2-(5-Methoxy-1H-indol-3-yl)ethyl)acetamide
N-(2-(5-Methoxyindol-3-yl)ethyl)-Acetamide
N-(2-(5-Methoxyindol-3-yl)ethyl)acetamide
N-Acetyl-5-methoxy-tryptamine
N-Acetyl-5-methoxy-tryptamine Melatonine
N-Acetyl-5-methoxytryptamine
N-[2-(5-Methoxy-1H-indol-3-yl)-ethyl]-acetamide
N-[2-(5-Methoxy-1H-indol-3-yl)ethyl)acetamide
N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]-Acetamide
N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]acetamide
N-[2-(5-Methoxyindol-3-yl)ethyl]-Acetamide
N-[2-(5-Methoxyindol-3-yl)ethyl]acetamide
N-[2-(5-methoxyindol-3-yl)ethyl]acetamide
N-acetyl-5-methoxy-tryptamine
NCGC00015680-01
NCGC00015680-02
NCGC00015680-03
NCGC00015680-06
NCGC00015680-13
NCGC00090727-01
NCGC00090727-02
NCGC00090727-03
NCGC00090727-04
NCGC00090727-05
NCGC00090727-06
NCGC00090727-07
NCGC00090727-08
NCGC00090727-09
NCI60_004378
NINDS_000353
NMR/14327425
NSC 113928
NSC113928
NSC56423
Nature'S Harmony
Night Rest
Oprea1_104553
Oprea1_814234
PREVENTION 1 (MELATONIN) (PREVENTION 1)
PREVENTION 2 (MELATONIN)
PREVENTION 3 (MELATONIN)
PREVENTION 4 (MELATONIN)
PREVENTION 5 (MELATONIN)
Pineal Hormone
Posidorm
Prestwick0_000458
Prestwick1_000458
Prestwick2_000458
Prestwick3_000458
Prestwick_312
Regulin
Revital Melatonin
Rx Balance
S1204_Selleck
SDCCGMLS-0065812.P001
SDCCGMLS-0065812.P002
SMP2_000309
SMR000326666
SPBio_001527
SPBio_002475
SPECTRUM1500690
STK386880
Sleep Right
Spectrum2_001344
Spectrum3_001393
Spectrum4_000066
Spectrum5_001745
Spectrum_000185
TNP00300
UNII-JL5DK93RCL
Vivitas
WLN: T56 BMJ D2MV1 GO1
ZINC00057060
{N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-} Acetamide
{N-[2-(5-methoxyindol-3-yl)ethyl]-} Acetamide
2AntioxidantsPhase 42928
3Central Nervous System DepressantsPhase 412806
4Protective AgentsPhase 4, Phase 3, Phase 17190
5
EthanolapprovedPhase 3204364-17-5702
Synonyms:
(C6-C9)Alkyl alcohol
02483_FLUKA
02851_FLUKA
02853_FLUKA
02854_FLUKA
02855_FLUKA
02856_FLUKA
02856_SIAL
02857_FLUKA
02857_SIAL
02858_FLUKA
02858_SIAL
02860_FLUKA
02865_FLUKA
02865_SIAL
02870_FLUKA
02870_SIAL
02875_FLUKA
02877_FLUKA
02878_FLUKA
02882_FLUKA
02882_SIAL
02883_FLUKA
02884_FLUKA
02890_FLUKA
02890_SIAL
02891_FLUKA
02891_SIAL
1-Hydroxyethane
100C.NPA
121182-78-3
187380_ALDRICH
187380_SIAL
24102_RIEDEL
24102_SIAL
24103_RIEDEL
24103_SIAL
24105_RIEDEL
24105_SIAL
24106_RIEDEL
24106_SIAL
24194_RIEDEL
24194_SIAL
245119_ALDRICH
245119_SIAL
270741_ALDRICH
270741_SIAL
277649_ALDRICH
277649_SIAL
2858_SIGMA
29221_FLUKA
32205_RIEDEL
32205_SIAL
32221_RIEDEL
32221_SIAL
32294_RIEDEL
32294_SIAL
34870_SIAL
34963_RIEDEL
39278_FLUKA
40210_ALDRICH
40210_RIEDEL
41322_FLUKA
458600_ALDRICH
458600_SIAL
459828_ALDRICH
459828_SIAL
459836_ALDRICH
459836_SIAL
459844_SIAL
48075_SUPELCO
493511_SIAL
493538_ALDRICH
493538_SIAL
493546_ALDRICH
493546_SIAL
64-17-5
676829_SIAL
68475-56-9
71076-86-3
71329-38-9
8000-16-6
8024-45-1
AC1L19TW
AC1Q31MM
AHD 2000
AI3-01706
ALCOHOL 5% IN D5-W
Absolute Alcohol
Absolute Ethanol
Absolute alcohol
Absolute ethanol
Absolute ethyl alcohol
Aethanol
Aethanol [German]
Aethylalkohol
Alcare Hand Degermer
Alcohol
Alcohol (USP)
Alcohol (ethyl)
Alcohol Anhydrous
Alcohol [USP]
Alcohol anhydrous
Alcohol dehydrated
Alcohol denatured
Alcohol etílico
Alcohol, Absolute
Alcohol, Dehydrated
Alcohol, Diluted
Alcohol, Grain
Alcohol, anhydrous
Alcohol, dehydrated
Alcohol, denatured
Alcohol, diluted
Alcohol, ethyl
Alcohols
Alcohols, C1-3
Alcohols, C30
Alcohols, C6-9
Alcool Ethylique
Alcool Etilico
Alcool ethylique
Alcool etilico
Alcool éthylique
Algrain
Alkohol
Alkohol [German]
Alkoholu Etylowego
Alkoholu etylowego
Aminoethanol
Anhydrol
Anhydrol PM 4085
Anhydrous alcohol
Anhydrous ethanol
Beta-Aminoethanol
Beta-Aminoethyl Alcohol
Beta-Ethanolamine
Beta-Hydroxyethylamine
C00469
C2H5OH
C2H6O
CCRIS 945
CDA 19
CDA 19-200
CHEBI:16236
CHEMBL545
CID702
Caswell No. 426
Caswell No. 430
Colamine
Cologne Spirit
Cologne spirit
Cologne spirits
 
D000431
D00068
DB00898
Dehydrated Ethanol
Dehydrated alcohol
Dehydrated ethanol
Denatured Alcohol
Denatured Alcohol Cd-10
Denatured Alcohol Cd-5
Denatured Alcohol Cd-5a
Denatured Alcohol Sd-1
Denatured Alcohol Sd-13a
Denatured Alcohol Sd-17
Denatured Alcohol Sd-23a
Denatured Alcohol Sd-28
Denatured Alcohol Sd-30
Denatured Alcohol Sd-39b
Denatured Alcohol Sd-39c
Denatured Alcohol Sd-3a
Denatured Alcohol Sd-40m
Denatured Ethanol
Denatured alcohol
Denatured ethanol
Desinfektol EL
Diluted Alcohol
Distilled spirits
E2385_SIGMA
E7023_ALDRICH
E7023_SIAL
E7148_ALDRICH
E7148_SIAL
E7517_SIGMA
EINECS 200-578-6
EINECS 270-649-4
EOH
EOX
ETA
Envision Conditioner Pdd 9020
Esumiru WK 88
EtOH
Etanolo
Etanolo [Italian]
Ethanol (9CI)
Ethanol 200 Proof
Ethanol 200 proof
Ethanol Absolute
Ethanol Absolute Bp
Ethanol Anhydrous
Ethanol Extra Pure
Ethanol Vapor
Ethanol [JAN]
Ethanol solution
Ethanol, Silent Spirit
Ethanol, undenatured
Ethanolum anhydricum
Ethicap
Ethyl Alcohol
Ethyl Alcohol & Water, 10%
Ethyl Alcohol & Water, 20%
Ethyl Alcohol & Water, 30%
Ethyl Alcohol & Water, 40%
Ethyl Alcohol & Water, 5%
Ethyl Alcohol & Water, 50%
Ethyl Alcohol & Water, 60%
Ethyl Alcohol & Water, 70%
Ethyl Alcohol & Water, 80%
Ethyl Alcohol & Water, 95%
Ethyl Alcohol & Water, 96%
Ethyl Alcohol Anhydrous
Ethyl Alcohol, Anhydrous
Ethyl Alcohol, Denatured
Ethyl Hydrate
Ethyl Hydroxide
Ethyl alc
Ethyl alcohol
Ethyl alcohol anhydrous
Ethyl alcohol in alcoholic beverages
Ethyl alcohol usp
Ethyl hydrate
Ethyl hydroxide
Ethylalcohol
Ethylalcohol [Dutch]
Ethylol
Ethylolamine
Ethyloxy Group
Etylowy alkohol
FEMA No. 2419
FEMA Number 2419
Fermentation alcohol
Glycinol
Grain alcohol
HSDB 531
HSDB 82
HYDROXYETHYL GROUP
Hinetoless
Hydroxyethane
I14-12648
IMS 99
Infinity Pure
Jaysol
Jaysol S
LS-1539
LTBB002977
Lux
Methylated Spirit Mineralised
Methylated spirit
Methylcarbinol
MolPort-001-785-844
Molasses alcohol
NCGC00091458-01
NCI-C03134
NSC 85228
NSC85228
Oxydimethylene Group
Potato alcohol
Punctilious ethyl alcohol
Pyro
QMHAIh@
Reagent Alcohol
Ru-Tuss Expectorant
SDA 3A
SDA 40-2
SDM No. 37
SY Fresh M
Sekundasprit
Silent spirit
Spirit
Spirits of wine
Spiritus vini
Spirt
Synasol
Tecsol
Tecsol C
Thanol
Thiofaco M-50
UNII-3K9958V90M
USAF EK-1597
Undenatured Ethanol
WLN: Q2
absolute alcohol
alcohol
alcohol etilico
bmse000297
etanol
ethanol
ethyl alcohol
grain alcohol
nchem.651-comp3c
nchembio.552-comp10
nchembio.94-comp20
spiritus vini
Äthanol
Äthylalkohol
éthanol
6sodium fluorideapprovedPhase 31937681-49-4
7
TopiramateapprovedPhase 3, Phase 124797240-79-45284627
Synonyms:
-D-fructopyranose deriv.
.beta.-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, sulfamate (9CI)
2,3-4,5-bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate
2,3:4,5-Bis-O-(1-methylethylidene) .beta.-D-fructopyranose sulfamate
2,3:4,5-Bis-O-(1-methylethylidene)-36-D-fructo-pyranose sulfamate
2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate
2,3:4,5-Di- O -isopropylidene-(beta)-D-fructopyranose sulfamate
2,3:4,5-Di-O-isopropylidene-beta-D-fructopyranose sulfamate
5H-Bis[1,3]dioxolo[4,5-b:4',5'-d]pyran, .beta.
97240-79-4
AKOS000424547
BIDD:GT0854
BIDD:PXR0127
BRN 5988957
BSPBio_002306
C052342
C07502
C12H21NO8S
CBChromo1_000352
CHEBI:129573
CHEMBL220492
CID5284627
CPD000466325
Cilag brand of topiramate
D00537
DB00273
Epitoma
Epitomax
HMS1922H06
HMS2051L09
HMS2093D20
HSDB 7531
Janssen brand of topiramate
KS-1122
KW-6485
LS-187392
LS-69764
MLS000759431
MLS001424070
McN 4853
McN-4853
MolPort-001-615-062
MolPort-002-885-869
NCGC00178714-01
 
Ortho brand of topiramate
RWJ 17021
RWJ-17021
RWJ-17021-000
S1438_Selleck
SAM001246601
SMR000466325
SPBio_000995
SPECTRUM1505801
STOCK1N-71037
Spectrum2_001128
T0575_SIGMA
TL8006021
TOR
TPM
Tipiramate
Tipiramate [French]
Tipiramato
Tipiramato [Spanish]
Topamac
Topamax
Topamax (TN)
Topamax Sprinkle
Topamax, Topiramate
Topimax
Topina
Topiramate
Topiramate (JAN/USAN/INN)
Topiramate (TPM)
Topiramate / Placebo
Topiramate [USAN:BAN:INN]
Topiramato
Topiramato [INN-Spanish]
Topiramatum
Topiramatum [INN-Latin]
Topiramic acid
Topomax
UNII-0H73WJJ391
USL-255
[(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate
beta-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, sulfamate
beta.-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, 1-sulfamate
topiramate
topiramate tablet
topiramatum [Latin]
8
Clobazamapproved, illicitPhase 3, Phase 22022316-47-82789
Synonyms:
1-Phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-diketo-3H-1,5-benzodiazepine
1-Phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-dioxo-3H-1, 5-benzodiazepine
1-Phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-dioxo-3H-1,5-benzodiazepine
1-phenyl-5-methyl-8-chloro-1,2,4,5- tetrahydro-2,4-diketo-3H-1,5-benzodiazepine
1-phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-dioxo-3H-1,5-benzodiazepine
22316-47-8
4(3H,5H)-dione
5-24-08-00034 (Beilstein Handbook Reference)
7-Chloro-1-methyl-5-phenyl-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione
7-Chloro-1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,
7-Chloro-1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione
7-Chloro-1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,4-(3H,5H)-dione
7-chloro-1-methyl-5-phenyl-1,5-benzodiazepine-2,4-dione
AC-273
AC1L1EGZ
Ambap22316-47-8
BRN 0758410
C012255
C8414_SIGMA
CCRIS 7506
CHEBI:31413
CHEMBL70418
CID2789
Caastilium
Chlorepin
Clobazam
Clobazam (JAN/USAN/INN)
Clobazam [USAN:BAN:INN]
Clobazamum
 
Clobazamum [INN-Latin]
Clorepin
D01253
DB00349
DEA No. 2751
EINECS 244-908-7
Frisium
H 4723
H-4723
HR 376
LM 2717
LM-2717
LS-34098
MolPort-003-940-848
Mystan
Mystan (TN)
NCGC00168249-01
NSC 336279
NSC336279
Noiafren
Odipam
RU-4723
UNII-2MRO291B4U
Urbadan
Urbanil
Urbanyl
WLN: T67 GNV JVN IHJ CG G1 KR
ZINC00001175
clobazam
nchembio747-comp39
9
BenzocaineapprovedPhase 318921994-09-7, 94-09-72337
Synonyms:
(p-(Ethoxycarbonyl)phenylamine
06952_FLUKA
112909_ALDRICH
112909_SIAL
1333-08-0
23239-88-5
23239-88-5 (hydrochloride)
4 Aminobenzoic Acid Ethyl Ester
4-(Ethoxycarbonyl)aniline
4-(Ethoxycarbonyl)phenylamine
4-14-00-01129 (Beilstein Handbook Reference)
4-Aminobenzoate
4-Aminobenzoic acid
4-Aminobenzoic acid ethyl ester
4-Aminobenzoic acid, ethyl ester
4-Carbethoxyaniline
4-amino-benzoic acid ethyl ester
4-aminobenzoic acid ethyl ester
71123-91-6
94-09-7
94-09-7 (Parent)
A0271
AB00051923
AC1L1DGC
AC1Q341A
AC1Q64JE
AE-562/40377256
AI3-02081
AKOS000119763
AR-1H9065
Acetate, Benzocaine
Aethoform
Aethylium paraminobenzoicum
Amben ethyl ester
Americaine
Anaesthan-syngala
Anaesthesin
Anaesthesinum
Anaesthin
Anestezin
Anestezin [Russian]
Anesthesin
Anesthesine
Anesthone
BB_SC-0019
BPBio1_001017
BRD-K75466013-001-05-2
BRN 0638434
BSPBio_000923
BSPBio_001908
Baby Anbesol
Bensokain
Benzoak
Benzocaina
Benzocaina [INN-Spanish]
Benzocaine
Benzocaine (USP/INN)
Benzocaine Acetate
Benzocaine Formate
Benzocaine Hydrobromide
Benzocaine Hydrochloride
Benzocaine Methanesulfonate
Benzocaine [INN:BAN]
Benzocainum
Benzocainum [INN-Latin]
Benzoic acid, 4-amino-, ethyl ester
Benzoic acid, 4-amino-, ethyl ester, hydrochloride
Benzoic acid, amino-, ethyl ester
Benzoic acid, p-amino-, ethyl ester
C07527
CAS-94-09-7
CHEBI:116735
CHEMBL278172
CID2337
Caswell No. 430A
Chloraseptic
D001566
D00552
DB01086
Dermoplast
Diet Ayds
DivK1c_000932
E1501_SIGMA
EINECS 202-303-5
EPA Pesticide Chemical Code 097001
ETHYL-P-AMINOBENZOATE
Ethoform
Ethoforme
Ethyl 4-aminobenzoate
Ethyl 4-aminobenzoate hydrochloride
Ethyl 4-aminobenzoic acid
Ethyl Aminobenzoate
Ethyl PABA
 
Ethyl aminobenzoate
Ethyl aminobenzoate (JP15)
Ethyl aminobenzoate (VAN)
Ethyl aminobenzoic acid
Ethyl p-Aminobenzoate
Ethyl p-Aminophenylcarboxylate
Ethyl p-aminobenzenecarboxylate
Ethyl p-aminobenzoate
Ethyl p-aminobenzoic acid
Ethyl p-aminophenylcarboxylate
Ethylester kyseliny p-aminobenzoove
Ethylester kyseliny p-aminobenzoove [Czech]
Ethylis aminobenzoas
Formate, Benzocaine
HMS1570O05
HMS1920G09
HMS2091M11
HMS502O14
HSDB 7225
Hurricaine
Hydrobromide, Benzocaine
Hydrochloride, Benzocaine
I05-0204
IDI1_000932
Identhesin
KBio1_000932
KBio2_000474
KBio2_003042
KBio2_005610
KBio3_001408
KBioGR_000658
KBioSS_000474
Keloform
LS-35847
MLS001331704
MLS002153970
Methanesulfonate, Benzocaine
MolPort-000-871-526
NCGC00016352-01
NCGC00094598-01
NCGC00094598-02
NINDS_000932
NSC 122792
NSC 41531
NSC41531
NSC4688
Norcain
Norcaine
Norcainum
Oprea1_750694
Oprea1_827402
Ora-jel
Orabase-B
Orthesin
Otocain
Outgro
Parathesin
Parathesin (TN)
Parathesine
Prestwick0_000712
Prestwick1_000712
Prestwick2_000712
Prestwick3_000712
Prestwick_991
SMR000059025
SPBio_000134
SPBio_002844
SPECTRUM1500139
STK043620
Slim Mint Gum
Solarcaine
Solu H
Spectrum2_000117
Spectrum3_000314
Spectrum4_000249
Spectrum5_000860
Spectrum_000074
Topcaine
UNII-U3RSY48JW5
WLN: ZR DVO2
ZINC12358719
benzocaine
ethylaminobenzoate-4
h-4-abz-oet
nchembio.182-comp4
p-(Ethoxycarbonyl)aniline
p-Aminobenzoate
p-Aminobenzoic acid
p-Aminobenzoic acid ethyl ester
p-Aminobenzoic acid, ethyl ester
p-Aminobenzoic ethyl ester
p-Carbethoxyaniline
p-Ethoxycarboxylic Aniline
p-Ethoxycarboxylic aniline
10
EzogabineapprovedPhase 3, Phase 227150812-12-7121892
Synonyms:
150812-12-7
AC-6908
AC1L3TLD
ADD-230001
C101866
C13826
C16H18FN3O2
CHEBI:161945
CHEMBL41355
CID121892
Carbamic acid, (2-amino-4-(((4-fluorophenyl)methyl)amino)phenyl)-, ethyl ester
D 20443
D 23129
D-20443
D-23129
EZG
Ethyl (2-amino-4-(((4-fluorophenyl)methyl)amino)phenyl)carbamate
Ethyl 2-amino-4-((P-fluorobenzyl)amino)carbanilate
Ethyl 2-amino-4-((p-fluorobenzyl)amino)carbanilate
Ethyl {2-amino-4-[(4-fluorobenzyl)amino]phenyl}carbamate
 
Ezogabine
FT-0080801
GKE-841
I06-0810
KE-0201
LS-48932
MolPort-003-850-148
N-(2-Amino-4-(4-fluorobenzylamino)-phenyl) carbamic acid ethyl ester
N-(2-Amino-4-(4-fluorobenzylamino)phenyl)carbamic acid ethyl ester
Potiga
RTG
Retigabine
Retigabine [USAN]
TL80090034
Trobalt
UNII-12G01I6BBU
ZINC00016154
[2-Amino-4-[[(4-fluorophenyl)methyl]amino]phenyl]-carbamate
ethyl N-(2-amino-4-(4-fluorobenzylamino)phenyl)carbamate hydrochloride
ethyl N-[2-amino-4-[(4-fluorophenyl)methylamino]phenyl]carbamate
nchembio874-comp3
11tannic acidapproved, NutraceuticalPhase 31892
12AnticonvulsantsPhase 3, Phase 2, Phase 12620
13ListerinePhase 3193
14Neuroprotective AgentsPhase 3, Phase 11672
15Anti-Obesity AgentsPhase 3, Phase 1411
16Pharmaceutical SolutionsPhase 37793
17StrawberryNutraceuticalPhase 380
18Neurotransmitter AgentsPhase 217734
19Serotonin Uptake InhibitorsPhase 21570
20Serotonin AgentsPhase 23102
21Neurotransmitter Uptake InhibitorsPhase 23464
22
SerotoninPhase 2356650-67-95202
Synonyms:
3-(2-Aminoethyl)-1H-indol-5-ol
3-(2-Aminoethyl)indol-5-ol
3-(b-Aminoethyl)-5-hydroxyindole
5-HT
5-HTA
5-Hydroxy-3-(b-aminoethyl)indole
 
5-Hydroxy-tryptamine
5-Hydroxyltryptamine
5-Hydroxytriptamine
5-Hydroxytryptamine
Antemovis
DS substance
Enteramin
Enteramine
23
Dronabinolapproved, illicitPhase 11381972-08-316078, 2978
Synonyms:
(-)- delta 9-Tetrahydrocannabinol
(-)-.DELTA.1-Tetrahydrocannabinol
(-)-.DELTA.9-THC
(-)-.DELTA.9-Tetrahydrocannabinol
(-)-.DELTA.9-trans-Tetrahydrocannabinol
(-)-.delta.(sup9)-trans-Tetrahydrocannabinol
(-)-3,4-trans-Delta1-Tetrahydrocannabinol
(-)-delta (sup9)-trans-Tetrahydrocannabinol
(-)-delta 1-Tetrahydrocannabinol
(-)-delta 9-THC
(-)-delta 9-trans-Tetrahydrocannabinol
(-)-delta(sup 1)-3,4-trans-Tetrahydrocannabinol
(-)-delta1-Tetrahydrocannabinol
(-)-delta9-(trans)-Tetrahydrocannabinol
(-)-delta9-Tetrahydrocannabinol
(-)-delta9-trans-Tetrahydrocannabinol
(-)-trans-.DELTA.9-Tetrahydrocannabinol
(-)-trans-Delta1-Tetrahydrocannabinol
(-)-trans-Delta9-THC
(-)-trans-delta 1-Tetrahydrocannabinol
(-)-trans-delta 9-THC
(-)-trans-delta 9-Tetrahydrocannabinol
(-)-trans-delta9-Tetrahydrocannabinol
(L)-.delta.1-Tetrahydrocannabinol
(L)-delta 1-Tetrahydrocannabinol
(l)-delta(sup 1)-Tetrahydrocannabinol
(l)-delta1-Tetrahydrocannabinol
.DELTA.1-THC
.DELTA.1-Tetrahydrocannabinol
.DELTA.9-THC
.DELTA.9-trans-Tetrahydrocannabinol
.delta.(sup9)-THC
.delta.-9-THC
1-trans-.delta.(sup9)-tetrahydrocannabinol
1-trans-D9-Tetrahydrocannabinol
1-trans-delta (sup9)-tetrahydrocannabinol
1-trans-delta 9-Tetrahydrocannabinol
1-trans-delta(sup 9)-Tetrahydrocannabinol
1-trans-delta(sup9)-tetrahydrocannabinol
1-trans-delta-9-Tetrahydrocannabinol
1-trans-delta9-Tetrahydrocannabinol
1363-19-5
14146-29-3
14146-43-1
14C-.DELTA.1-Tetrahydrocannabinol
14C-delta 1-Tetrahydrocannabinol
1972-08-3
26108-45-2
3-Pentyl-6,6,9-trimethyl-6a,7,8,10a-tetrahydro-6H-dibenzo(b,D)pyran-1-ol
308064-99-5
5957-27-7
6,6,9-Trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol
6465-30-1
6H-Dibenzo
9-delta-Tetrahydrocannabinol
9-ene-Tetrahydrocannabinol
9-tetrahydrocannabinol
AC1L277U
AC1Q2VRZ
Abbott 40566
BIDD:GT0427
C06972
CAT-310
CCRIS 4726
CHEBI:104496
CHEMBL465
CID16078
Cannabinol, Delta1-tetrahydro- (7CI)
Cannabinol, tetrahydro- (6CI)
Cannabis resin
Compassia
D00306
DB00470
DEA No. 7369
DEA No. 7370
DRG-0138
Delta9-Tetrahydrocannabinol solution
Deltanyne
Drona binol
Dronabinol
Dronabinol (USP/INN)
Dronabinol [USAN:INN]
Dronabinolum
Dronabinolum [Latin]
 
EPA 28
EPA-PLUS
Exocyclic delta (9)(11)-Tetrahydrocannabiol
Fats and Glyceridic oils, fish, n-3 fatty acid-high
Fish oils, n-3 fatty acid-high
Fish oils, omega-3 fatty acid-high
Ganja
HSDB 6471
Hashish
L-.delta.1-Tetrahydrocannabinol
L-.delta.1-trans-Tetrahydrocannabinol
L-delta 1-trans-Tetrahydrocannabinol
L-delta(sup 1)-tetrahydrocannabinol
L-delta1-trans-Tetrahydrocannabinol
L-trans-.delta.9-Tetrahydrocannabinol
L-trans-delta 9-Tetrahydrocannabinol
L-trans-delta9-Tetrahydrocannabinol
LS-975
Marincap
Marinol
Marinol (TN)
MaxEPA
MolPort-003-959-698
NSC 134454
NSC134454
Namisol
Omegaven
PDSP2_000714
Primolut
Pro-Mega
Promega
QCD 84924
QCD-84924
Relivar
SP 104
Sonergx
T2386_SIGMA
T4764_FLUKA
T4764_SIGMA
TETRAHYDROCANNABINOL
THC
THC-delta-9
Tetrahydrocannabinol
Tetrahydrocannabinol delta9
Tetrahydrocannabinols (-)-delta1-3,4-trans-form
Tetranabinex
UNII-7J8897W37S
ZINC01530625
delta (sup9)-Thc
delta 1-THC
delta 1-Tetrahydrocannabinol
delta 9-THC
delta 9-Tetrahydrocannabinol
delta 9-trans-Tetrahydrocannabinol
delta(1)-THC
delta(1)-Tetrahydrocannabinol
delta(9)-THC
delta(9)-Tetrahydrocannabinol
delta(9)-Tetrahydrocannibinol
delta(sup 1)-Tetrahydrocannabinol
delta(sup 1)-Thc
delta(sup 9)-Tetrahydrocannabinol
delta(sup 9)-Thc
delta-9-THC
delta-9-Tetrahydrocannabinol
delta-9-tetrahydrocannabinol
delta-THC
delta1-THC
delta1-Tetrahydrocannabinol
delta1-Tetrahydrocannabinol (VAN)
delta9-THC
delta9-Tetrahydrocannabinol
delta9-Tetrahydrocannabinol (VAN)
delta9-trans-Tetrahydrocannabinol
nchembio.129-comp1
nchembio.552-comp1
nchembio.86-comp3
omega-3-Fatty acid
trans-.DELTA.9-Tetrahydrocannabinol
trans-delta (-)-9-Tetrahydrocannabinol
trans-delta 9-Tetrahydrocannabinol
trans-delta-9-Tetrahydrocannabinol
trans-delta9-Tetrahydrocannabinol
trans-tetrahydrocannabinol
Δ9-tetrahydrocannabinol
24
Lamotrigineapproved, investigational18384057-84-13878
Synonyms:
3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine
3,5-Diamino-6-(2,3-dichlorophenyl)-as-triazine
3,5-diamino-6-(2,3-dichlorophenyl)- as -triazine
6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diyldiamine
6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine
84057-84-1
AC-10298
AC1L1GWT
BIDD:GT0794
BW 430C
BW-430C
Bio-0056
C047781
CHEBI:138727
CHEBI:6367
CHEMBL741
CID3878
CPD000058464
Crisomet
D00354
DB00555
Desitin Brand of Lamotrigine
EINECS 281-901-8
EU-0100688
EUR-1048
Faes Brand of Lamotrigine
GI 267119X
GW 273293
Glaxo Wellcome Brand of Lamotrigine
GlaxoSmithKline Brand of Lamotrigine
HMS2051C10
HMS2089M08
HMS2093P21
HSDB 7526
Juste Brand of Lamotrigine
L 3791
L3791_SIGMA
LS-155249
 
Labileno
Lamictal
Lamictal (TN)
Lamictal CD
Lamictal Cd
Lamictal ODT
Lamictal XR
Lamictin
Lamiktal
Lamitor
Lamotrigina
Lamotrigina [Spanish]
Lamotrigine
Lamotrigine (JAN/USAN/INN)
Lamotrigine [USAN:INN:BAN]
Lamotriginum
Lamotriginum [Latin]
Lopac-L-3791
Lopac0_000688
MLS000069685
MLS000759486
MLS001077325
MolPort-003-666-744
NCGC00015605-01
NCGC00015605-02
NCGC00015605-06
NCGC00015605-08
NCGC00022936-02
NCGC00022936-04
NCGC00022936-05
NSC746307
SAM001246697
SMP2_000303
SMR000058464
STK628377
Tocris-1611
UNII-U3H27498KS
ZINC00013156
lamotrigine
25Fluorodeoxyglucose F18392
26Excitatory Amino Acids1297
27Sodium Channel Blockers1515
28Diuretics, Potassium Sparing1827
29calcium channel blockers1940
30Calcium, Dietary5525
31Excitatory Amino Acid Antagonists1282

Interventional clinical trials:

(show all 32)
idNameStatusNCT IDPhase
1Melatonin Versus Placebo in the Lennox-Gastaut Syndrome: Neurophysiological and Neuropsychological EffectsUnknown statusNCT01370486Phase 4
2Transcranial Direct Current Stimulation, Treatment of Childhood Drug-Resistant Lennox-Gastaut Syndrome, A Pilot StudyCompletedNCT02731300Phase 4
3A Placebo-Controlled, Double-Blind Comparative Study of E2080 in Lennox-Gastaut Syndrome Patients (Study E2080-J081-304)CompletedNCT01146951Phase 3
4Study of Rufinamide in Pediatric Subjects 1 to Less Than 4 Years of Age With Lennox-Gastaut Syndrome Inadequately Controlled With Other Anti-epileptic DrugsCompletedNCT01405053Phase 3
5Safety and Effectiveness of Open-Label Clobazam in Subjects With Lennox-Gastaut SyndromeCompletedNCT01160770Phase 3
6A Study to Investigate the Efficacy and Safety of Cannabidiol (GWP42003-P; CBD) as Adjunctive Treatment for Seizures Associated With Lennox-Gastaut Syndrome in Children and AdultsCompletedNCT02224690Phase 3
7A Study to Investigate the Efficacy and Safety of Cannabidiol (GWP42003-P; CBD) as Adjunctive Treatment for Seizures Associated With Lennox-Gastaut Syndrome in Children and AdultsCompletedNCT02224560Phase 3
8Phase III Randomized, Double-Blind, Placebo-Controlled Study of Oral Topiramate for Lennox-Gastaut SyndromeCompletedNCT00004776Phase 3
9Clobazam in Patients With Lennox-Gastaut SyndromeCompletedNCT00518713Phase 3
10A Study of the Efficacy and Safety of Topiramate as an add-on Therapy in the Treatment of Epilepsy Patients With Lennox-Gastaut SyndromeCompletedNCT00236756Phase 3
11A Long Term Extension Study of E2080 in Lennox-Gastaut PatientsCompletedNCT01151540Phase 3
12Study to Determine the Efficacy and Safety of Adjunctive Topiramate in the Treatment of Obsessive-Compulsive DisorderCompletedNCT00187928Phase 3
13Cannabidiol Oral Solution as an Adjunctive Treatment for Treatment-resistant Seizure DisorderActive, not recruitingNCT02318602Phase 3
14An Open Label Extension Study of Cannabidiol (GWP42003-P) in Children and Young Adults With Dravet or Lennox-Gastaut SyndromesEnrolling by invitationNCT02224573Phase 3
15Study of Perampanel as Adjunctive Treatment for Inadequately Controlled Seizures Associated With Lennox-Gastaut SyndromeNot yet recruitingNCT02834793Phase 3
16Cannabidiol Oral Solution as an Adjunctive Therapy for Treatment of Subjects With Inadequately Controlled Lennox-Gastaut SyndromeNot yet recruitingNCT02318537Phase 3
17Long-term, Open-label Safety Extension Study of Retigabine/Ezogabine in Pediatric Subjects (>= 12 Years Old) With POS or LGSTerminatedNCT01668654Phase 3
18Clobazam in Subjects With Lennox-Gastaut SyndromeCompletedNCT00162981Phase 2
19Add-on Therapy With Low Dose Fenfluramine in Lennox Gastaut EpilepsyRecruitingNCT02655198Phase 2
20Study in Pediatric Subjects With EpilepsyTerminatedNCT01494584Phase 2
21A Study of the Pharmacokinetics, Safety and Tolerability of Topiramate in Infants (Age 1-24 Months) With Refractory Partial-onset SeizuresCompletedNCT00233012Phase 1
22Cannabidiol in Children With Refractory Epileptic EncephalopathyNot yet recruitingNCT03024827Phase 1
23Epilepsy Phenome/Genome ProjectUnknown statusNCT00552045
24European Registry of Anti-Epileptic Drug Use in Patients With Lennox-Gastaut Syndrome (LGS)CompletedNCT01991041
25A Study of the Safety of Topiramate Given in Combination With Other Medications in Adults and Children With SeizuresCompletedNCT00297349
26Ketogenic Diet for Child Epilepsy and Seizure ControlCompletedNCT00004729
27Special Drug Use Investigation for LAMICTAL® (Long Term)CompletedNCT01863602
28Metabolic Abnormalities in Children With EpilepsyCompletedNCT00001325
29Trial to Assess Vagus Nerve Stimulation Therapy in Children With Lennox-Gastaut SyndromeRecruitingNCT02632149Early Phase 1
30Post-marketing Surveillance of Long-term Administration of Inovelon Tablets in Patients With Lennox-Gastaut SyndromeActive, not recruitingNCT02175173
31The Pharmacokinetics of Cannabidiol (CBD) and Its Effects in Children With Severe EpilepsyNot yet recruitingNCT02910297
32The Effects of Cannabidiol (CBD) on Electrical and Autonomic Cardiac Function in Children With Severe EpilepsyNot yet recruitingNCT02815540

Search NIH Clinical Center for Lennox-Gastaut Syndrome

Genetic Tests for Lennox-Gastaut Syndrome

About this section

Genetic tests related to Lennox-Gastaut Syndrome:

id Genetic test Affiliating Genes
1 Epileptic Encephalopathy Lennox-Gastaut Type27
2 Epileptic Encephalopathy, Lennox-Gastaut Type24 MAPK10

Anatomical Context for Lennox-Gastaut Syndrome

About this section

MalaCards organs/tissues related to Lennox-Gastaut Syndrome:

36
Brain, Eye, Cortex, Thalamus, Liver, Heart

Publications for Lennox-Gastaut Syndrome

About this section

Articles related to Lennox-Gastaut Syndrome:

(show top 50)    (show all 298)
idTitleAuthorsYear
1
Spectral characteristics of intracranial electroencephalographic activity in patients with Lennox-Gastaut syndrome. (27686687)
2017
2
Clobazam-treated patients with Lennox-Gastaut syndrome experienced fewer seizure-related injuries than placebo patients during trial OV-1012. (27145465)
2016
3
Predictive role of brain connectivity for resective surgery in Lennox-Gastaut syndrome. (27417063)
2016
4
Lacosamide in Lennox-Gastaut Syndrome? Caution Is Still Needed. (27827811)
2016
5
Safety and pharmacokinetic profile of rufinamide in pediatric patients aged less than 4 years with Lennox-Gastaut syndrome: An interim analysis from a multicenter, randomized, active-controlled, open-label study. (26805435)
2016
6
Challenges in identifying Lennox-Gastaut syndrome in adults: A case series illustrating its changing nature. (26977407)
2016
7
Anesthetic management of a child with Lennox-Gastaut syndrome with intractable epilepsy posted for intracranial surgery! (27857813)
2016
8
Abnormal cognitive network interactions in Lennox-Gastaut syndrome: A potential mechanism of epileptic encephalopathy. (26945476)
2016
9
Brainstem dysfunction in patients with late-onset Lennox-Gastaut syndrome: Voxel-based morphometry and tract-based spatial statistics study. (27994367)
2016
10
Combined surgical intervention with vagus nerve stimulation following corpus callosotomy in patients with Lennox-Gastaut syndrome. (26979179)
2016
11
An unfortunate challenge: Ketogenic diet for the treatment of Lennox-Gastaut syndrome in tyrosinemia type 1. (27052529)
2016
12
Treatment of Adults with Lennox-Gastaut Syndrome: Further Analysis of Efficacy and Safety/Tolerability of Rufinamide. (26861566)
2016
13
Therapeutic effects of the ketogenic diet in children with Lennox-Gastaut syndrome. (27846468)
2016
14
Long-term safety and seizure outcome in Japanese patients with Lennox-Gastaut syndrome receiving adjunctive rufinamide therapy: An open-label study following a randomized clinical trial. (26827266)
2016
15
Transcranial Direct Current Stimulation for Treatment of Childhood Pharmacoresistant Lennox-Gastaut Syndrome: A Pilot Study. (27199889)
2016
16
Resective surgery combined with corpus callosotomy for children with non-focal lesional Lennox-Gastaut syndrome. (27629372)
2016
17
Nocturnal interictal epileptic discharges in adult Lennox-Gastaut syndrome: the effect of sleep stage and time of night. (26842220)
2016
18
Pontine and cerebral atrophy in Lennox-Gastaut syndrome. (26808205)
2016
19
Drug-resistant epilepsy after treatment for childhood acute lymphocytic leukaemia: from focal epilepsy to Lennox-Gastaut syndrome. (27934621)
2016
20
An Observational Report of Worsening Seizures with Increase in Total Charge Delivered Per Day by Vagus Nerve Stimulation in 4 Patients with Lennox-Gastaut Syndrome. (26705197)
2016
21
Comprehensive overview: efficacy, tolerability, and cost-effectiveness of clobazam in Lennox-Gastaut syndrome. (26089675)
2015
22
Lennox-Gastaut syndrome may be a curable, reversible epileptic encephalopathy. (25778755)
2015
23
Perceived efficacy of cannabidiol-enriched cannabis extracts for treatment of pediatric epilepsy: A potential role for infantile spasms and Lennox-Gastaut syndrome. (25935511)
2015
24
Clobazam is equally safe and efficacious for seizures associated with Lennox-Gastaut syndrome across different age groups: Post hoc analyses of short- and long-term clinical trial results. (25940107)
2015
25
Endoscopic-Assisted (Through a Mini Craniotomy) Corpus Callosotomy Combined With Anterior, Hippocampal, and Posterior Commissurotomy in Lennox-Gastaut Syndrome: A Pilot Study to Establish Its Safety and Efficacy. (26474092)
2015
26
Management of difficult airway with inhalation induction in a patient with Lennox-Gastaut syndrome and neck injury. (25687944)
2015
27
In response: Lennox-Gastaut syndrome may be a curable, reversible epileptic encephalopathy. (25778756)
2015
28
The causal epileptic network identifies the primary epileptogenic zone in Lennox-Gastaut syndrome. (26513494)
2015
29
Efficacy and tolerability of add-on Lacosamide treatment in adults with Lennox-Gastaut syndrome: An observational study. (26606192)
2015
30
Long-term prognosis of patients with Lennox--Gastaut syndrome in recent decades. (25616450)
2015
31
Relationship of Lennox-Gastaut syndrome with perinatal event: A cross-sectional study. (26167208)
2015
32
Clobazam and Aggression-Related Adverse Events in Pediatric Patients With Lennox-Gastaut Syndrome. (26245776)
2015
33
Retention rates of rufinamide in pediatric epilepsy patients with and without Lennox-Gastaut Syndrome. (25847334)
2015
34
Lennox-Gastaut syndrome. Management update. (26166587)
2015
35
Lennox-Gastaut syndrome: impact on the caregivers and families of patients. (25336963)
2014
36
Efficacy and tolerability of add-on Lacosamide in children with Lennox-Gastaut syndrome. (25052288)
2014
37
Withdrawal-related adverse events from clinical trials of clobazam in Lennox-Gastaut syndrome. (24949576)
2014
38
Rufinamide as an adjunctive therapy for Lennox-Gastaut syndrome: A randomized double-blind placebo-controlled trial in Japan. (25219353)
2014
39
Surgical options for patients with Lennox-Gastaut syndrome. (25284034)
2014
40
Should be prescribed lacosamide in patients with Lennox-Gastaut syndrome? (25052286)
2014
41
Anterior corpus callosotomy in school-aged children with Lennox-Gastaut syndrome: A prospective study. (24912732)
2014
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Adjunctive levetiracetam treatment in pediatric Lennox-Gastaut syndrome. (25266616)
2014
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Conceptualizing lennox-gastaut syndrome as a secondary network epilepsy. (25400619)
2014
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The efficacy and tolerability of pharmacologic treatment options for Lennox-Gastaut syndrome. (25284033)
2014
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Anaesthetic management in a patient with Lennox-Gastaut syndrome. (24963210)
2014
46
Clobazam is efficacious for patients across the spectrum of disease severity of Lennox-Gastaut syndrome: Post hoc analyses of clinical trial results by baseline seizure-frequency quartiles and VNS experience. (25282105)
2014
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Experience in the use of clobazam in the treatment of Lennox-Gastaut syndrome. (24790647)
2014
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A case of Lennox-Gastaut syndrome in a patient with FOXG1-related disorder. (25266269)
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CHD2 mutations in Lennox-Gastaut syndrome. (24614520)
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Introduction: Recommendations regarding management of patients with Lennox-Gastaut syndrome. (25284031)
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Variations for Lennox-Gastaut Syndrome

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Clinvar genetic disease variations for Lennox-Gastaut Syndrome:

5
id Gene Variation Type Significance SNP ID Assembly Location
1SCN1ANM_006920.4(SCN1A): c.4874G> A (p.Arg1625Gln)SNVLikely pathogenic, Pathogenicrs121917995GRCh37Chr 2, 166848878: 166848878

Expression for genes affiliated with Lennox-Gastaut Syndrome

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Search GEO for disease gene expression data for Lennox-Gastaut Syndrome.

Pathways for genes affiliated with Lennox-Gastaut Syndrome

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GO Terms for genes affiliated with Lennox-Gastaut Syndrome

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Cellular components related to Lennox-Gastaut Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1axon initial segmentGO:004319410.7KCNQ2, SCN1A
2node of RanvierGO:003326810.6KCNQ2, SCN1A
3GABA receptor complexGO:190271010.4GABRA1, GABRB2
4chloride channel complexGO:00347079.7GABRA1, GABRB2, GABRB3, GABRG2
5GABA-A receptor complexGO:19027119.7GABRA1, GABRB2, GABRB3, GABRG2
6postsynaptic membraneGO:00452119.1GABRA1, GABRB2, GABRB3, GABRG2

Biological processes related to Lennox-Gastaut Syndrome according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1inner ear receptor cell developmentGO:006011910.7GABRB2, GABRB3
2innervationGO:006038410.7GABRB2, GABRB3
3layer formation in cerebral cortexGO:002181910.4ADGRG1, DCX
4gamma-aminobutyric acid signaling pathwayGO:000721410.1GABRA1, GABRB2, GABRG2
5cellular response to histamineGO:00714209.9GABRA1, GABRB2, GABRB3, GABRG2
6chloride transmembrane transportGO:19024769.9GABRA1, GABRB2, GABRB3, GABRG2
7synaptic transmission, GABAergicGO:00519329.9DNM1, GABRA1, GABRB2, GABRG2
8ion transmembrane transportGO:00342209.9GABRA1, GABRB2, GABRB3, GABRG2
9transportGO:00068109.1GABRA1, GABRB2, GABRB3, GABRG2

Molecular functions related to Lennox-Gastaut Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1GABA receptor activityGO:001691710.2GABRA1, GABRB2
2extracellular ligand-gated ion channel activityGO:000523010.0GABRA1, GABRG2
3GABA-gated chloride ion channel activityGO:002285110.0GABRA1, GABRB3
4chloride channel activityGO:00052549.8GABRA1, GABRB2, GABRG2
5GABA-A receptor activityGO:00048909.3GABRA1, GABRB2, GABRB3, GABRG2

Sources for Lennox-Gastaut Syndrome

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet