Aliases & Classifications for Lens Disease

Summaries for Lens Disease

MalaCards based summary : Lens Disease, also known as lens diseases, is related to acquired hyperkeratosis and mosaic monosomy 22, and has symptoms including eye manifestations An important gene associated with Lens Disease is CRYAA (Crystallin Alpha A). The drugs Dipivefrin and Estradiol have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and testes, and related phenotype is vision/eye.

Related Diseases for Lens Disease

Diseases related to Lens Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
id Related Disease Score Top Affiliating Genes
1 acquired hyperkeratosis 10.8 OPTN PHEX
2 mosaic monosomy 22 10.7 GJA3 PAX6
3 mixed gonadal dysgenesis 10.7 OPTN PHEX
4 peptic esophagitis 10.7 CRYAA PHEX
5 multiple cranial nerve palsy 10.6 OPTN PEX19
6 female breast lower-outer quadrant cancer 10.6 CRYAA CRYGS LAMA3
7 glaucoma 3a, primary open angle, congenital, juvenile, or adult onset 10.6 CRYGS OPTN PAX6
8 gilles de la tourette syndrome 10.6 CRYGS MIP
9 lactocele 10.6 OPTN PAX6 PHEX
10 cataract 10.5
11 endometrial stromal nodule 10.5 CRYAA CRYGS MIP
12 anal spasm 10.5 FOXE3 OPTN PAX6
13 palindromic rheumatism 10.5 CRYAA CRYGS MIP
14 late congenital syphilis 10.5 CRYAA CRYGS MIP
15 catastrophic antiphospholipid syndrome 10.5 OCRL PITX3
16 congenital toxoplasmosis 10.5 AKR1B1 GBA3 VEGFA
17 visual epilepsy 10.5 CRYAA VEGFA
18 olecranon bursitis 10.4 CRYAA OPTN PEX19 PHEX
19 robinow syndrome 10.4 FOXE3 OPTN
20 anterior segment dysgenesis 2, multiple subtypes 10.4 FOXE3 PITX3
21 conjugate gaze palsy 10.4 CRYAA CRYGS OPTN VEGFA
22 ventricular extrasystoles with syncope, perodactyly, and robin sequence 10.3 OPTN VEGFA
23 congenital ichthyosiform erythroderma 10.3 OPTN VEGFA
24 hypermethioninemia 10.3 CRYAB GJA3 PITX3
25 pancreatic and cerebellar agenesis 10.3 CRYBB1 GJA3
26 isolated microphthalmia 10.3 FOXE3 PAX6 PITX3
27 skin granular cell tumor 10.2 CRYAA OPTN PAX6 PEX19 PHEX
28 breast-ovarian cancer, familial, 2 10.2 FOXE3 PAX6 PITX3
29 amyotrophic lateral sclerosis 12 10.2 CRYBB1 OPTN PHEX
30 anterior segment dysgenesis 5, multiple subtypes 10.2 FOXE3 PAX6 PITX3
31 cataract 11, multiple types 10.1 CRYGS FOXE3 PAX6 PITX3
32 cataract, total congenital 10.1 CRYAA CRYBB1
33 popliteal pterygium syndrome, bartsocas-papas type 10.0 CRYAA MIP
34 double outlet right ventricle with subaortic or doubly committed ventricular septal defect with pulmonary stenosis 9.7 CRYAA CRYAB CRYBB1 GJA3 MIP
35 myopathy, myofibrillar, fatal infantile hypertonic, alpha-b crystallin-related 9.6 CRYAA CRYAB CRYGS GJA3 MIP PITX3
36 cerebral palsy 9.1 CRYAA CRYAB CRYBB1 CRYGS GJA3 MIP
37 down syndrome 8.0 CRYAA CRYAB CRYBB1 CRYGA CRYGS GJA3
38 anorectal stricture 5.2 AKR1B1 CRYAA CRYAB CRYBB1 CRYGA CRYGS

Graphical network of the top 20 diseases related to Lens Disease:



Diseases related to Lens Disease

Symptoms & Phenotypes for Lens Disease

UMLS symptoms related to Lens Disease:


eye manifestations

MGI Mouse Phenotypes related to Lens Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 9.36 VEGFA AKR1B1 CRYAB CRYGA CRYGS GJA3

Drugs & Therapeutics for Lens Disease

Drugs for Lens Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 344)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dipivefrin Approved Phase 4,Phase 3 52365-63-6 3105
2
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-28-2 5757
3
Ethinyl Estradiol Approved Phase 4,Phase 2,Phase 3,Phase 1 57-63-6 5991
4
Moxifloxacin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 354812-41-2, 151096-09-2 152946
5
Norgestimate Approved Phase 4,Phase 2,Phase 3,Phase 1 35189-28-7 6540478
6
Ketorolac Approved Phase 4,Phase 3 74103-06-3, 66635-83-4 3826
7
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
8
Nepafenac Approved Phase 4,Phase 3,Phase 2 78281-72-8 151075
9
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
10
Loteprednol Approved Phase 4,Phase 3 82034-46-6, 129260-79-3 444025 9865442
11
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 3,Phase 1 9004-61-9 53477741 24759
12
Gabapentin Approved, Investigational Phase 4,Phase 1,Phase 2 60142-96-3 3446
13
Ephedrine Approved Phase 4,Phase 3,Phase 2,Phase 1 299-42-3 9294
14
Pseudoephedrine Approved Phase 4,Phase 3,Phase 2,Phase 1 90-82-4 7028
15
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
16
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-02-2 5743
17
Levofloxacin Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 100986-85-4 149096
18
Ofloxacin Approved Phase 4,Phase 3,Phase 1,Phase 2 82419-36-1 4583
19
Heparin Approved, Investigational Phase 4,Phase 2 9005-49-6 772 46507594
20
Betamethasone Approved, Vet_approved Phase 4,Phase 1,Phase 2 378-44-9 9782
21
Oxymetazoline Approved Phase 4,Phase 3 1491-59-4 4636
22
Phenylephrine Approved Phase 4,Phase 3 59-42-7 6041
23
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
24
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
25
Azithromycin Approved Phase 4 83905-01-5 55185 53477736 447043
26
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
27
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 124-94-7 31307
28
Vancomycin Approved Phase 4,Phase 3 1404-90-6 441141 14969
29
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
30 Racepinephrine Approved Phase 4
31
Dinoprostone Approved Phase 4 363-24-6 5280360
32
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 2,Phase 3 76631-46-4, 113775-47-6 68602 5311068 56032
33
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
34
Benzocaine Approved Phase 4 1994-09-7, 94-09-7 2337
35
Gatifloxacin Approved, Investigational Phase 4,Phase 1 112811-59-3 5379
36
Ciprofloxacin Approved, Investigational Phase 4,Phase 1,Phase 2 85721-33-1 2764
37
Bimatoprost Approved, Investigational Phase 4,Phase 2 155206-00-1 5311027
38
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 1 22916-47-8 4189
39
Dalteparin Approved Phase 4 9005-49-6
40
Indomethacin Approved, Investigational Phase 4 53-86-1 3715
41
Difluprednate Approved Phase 4,Phase 3 23674-86-4 443936
42
Brinzolamide Approved Phase 4 138890-62-7 68844
43
Tobramycin Approved, Investigational Phase 4,Phase 3,Phase 2 32986-56-4 5496 36294
44 Homatropine Approved Phase 4 87-00-3
45
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
46
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
47
Dexlansoprazole Approved Phase 4 138530-94-6, 103577-45-3 9578005
48
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
49
Theobromine Approved Phase 4 83-67-0 5429
50 Orange Approved, Nutraceutical Phase 4

Interventional clinical trials:

(show top 50) (show all 842)

id Name Status NCT ID Phase Drugs
1 Clinical Investigation of the Bi Flex M Multifocal IOL Unknown status NCT02338882 Phase 4
2 Clinical Investigation of the Modified Rayner Monofocal Aspheric 600C (With Axis Marks) Intraocular Lens Unknown status NCT02378636 Phase 4
3 A Intra-patient Comparison of Closed Loop and Plate Haptic Toric Intraocular Lenses Unknown status NCT02264457 Phase 4
4 Evaluation of Clinical Outcomes Following Implantation of a Sub-2mm Hydrophilic MICS Intraocular Lens Unknown status NCT01615861 Phase 4
5 AMO's Tecnis™ Multifocal Intraocular Lenses (Tecnis MF), Alcon's ReStor Multifocal IOL Unknown status NCT01278420 Phase 4
6 Show Improved Vision With the HOYA AF-1 Aspheric Intraocular Lens After Cataract Surgery Unknown status NCT01382641 Phase 4
7 Tear Film Evaluation After Phacoemulsification Unknown status NCT02238015 Phase 4
8 A Comparison of Prophylactic Antibacterial Efficacy of Besivance vs. VIGAMOX Prior to Cataract Surgery Unknown status NCT01296542 Phase 4
9 Aqueous Absorption and Pharmacokinetics of Besivance Versus VIGAMOX in Patients Undergoing Phacoemulsification Unknown status NCT01296191 Phase 4 Moxifloxacin;besifloxacin
10 Efficacy of Subtenon's Block With Olive Tipped Cannula Unknown status NCT01019018 Phase 4
11 Effect of Anti-inflammatory Topical Prednisolone, Nepafenac and Ketorolac in Intra-operative Mydriasis in Facetectomies Unknown status NCT00865540 Phase 4 prednisolone acetate 1%;ketorolac tromethamine 0.4%;nepafenac 0.1%;methylcellulose 0.5%
12 Randomized, Masked Comparison of Bromfenac and Besifloxacin BID With Either Prednisolone BID or Loteprednol 0.5% BID for Prevention of Retinal Thickening and CME Following Phacoemulsification Unknown status NCT01193504 Phase 4 Pred Forte;Lotemax
13 Combined Phacotube vs Phacotrabeculectomy:A Randomized Controlled Trial Unknown status NCT00273221 Phase 4
14 Open-angle Glaucoma Subjects on One Topical Hypotensive Medication Randomized to Treatment With One or Two Trabecular Micro-bypass Stents in Conjunction With Cataract Surgery Unknown status NCT01455467 Phase 4
15 A Study of the iStent in Combo With Cataract Surgery in Newly Diagnosed Open Angle Glaucoma or OH Patients. Unknown status NCT00326066 Phase 4
16 Effect of Posterior Corneal Toricity on Refractive Outcome of Pseudophakia Unknown status NCT01554761 Phase 4
17 Effect of Gabapentin on Pain of the Second Cataract Surgery Unknown status NCT02127853 Phase 4 gabapentin;placebo
18 Spherical Aberration and Contrast Sensitivity in IOLs Completed NCT00576485 Phase 4
19 Comparison of Functional Vision Provided by AMO Tecnis Z9000 and Alcon SA60AT Acrysof Completed NCT00459303 Phase 4
20 Evaluation of the Aspheric ReSTOR IOL After Routine Cataract Extraction Completed NCT00720005 Phase 4
21 Sedation Methods During Cataract Surgery Completed NCT03054103 Phase 4 Ketamine 10 MG/ML: 0.5 ML;Ketamine 10 MG/ML: 1 ML;Normal saline
22 Visual Acuity After the Combined Binocular Implantation of +2.75 Diopters and +3.25 Diopters Tecnis Multifocal Intraocular Lenses. Completed NCT02633072 Phase 4
23 Visual Acuity After the Combined Binocular Implantation of +2.5 Diopters and +3.0 Diopters ReSTOR Multifocal Intraocular Lenses. Completed NCT02314572 Phase 4
24 Visual Acuity After the Combined Binocular Implantation of +2.0 Diopters and +3.0 Diopters Oculentis Multifocal Intraocular Lenses. Completed NCT02633228 Phase 4
25 Comparison of the Quality of Vision Provided by AMO Tecnis Z9000 and Alcon Laboratories MA60 Acrysof Posterior Chamber Intraocular Lenses Completed NCT00348270 Phase 4
26 Visual Outcomes After Implantation of a New Multifocal Intraocular Lens Completed NCT01505816 Phase 4
27 Evaluation of Effective Lens Position With a Uniplanar Bi-aspheric IOL Completed NCT01248572 Phase 4
28 ACRYSOF® ReSTOR® Aspheric +3.0 D Add Power Intraocular Lens (IOL) Completed NCT00684138 Phase 4
29 Aurolab Hydrophobic Foldable Intraocular Lens Study Completed NCT00449267 Phase 4
30 Evaluation of the Safety & Effectiveness of the Bausch & Lomb AKREOS® TL Intraocular Lens Completed NCT00838045 Phase 4
31 Addressing of Efficacy and Safety of Femtosecond-laser Assisted Versus Manual Lens Fragmentation Procedure Completed NCT01971177 Phase 4
32 Check of Optical Features and Accuracy of the Zeiss ZO Lens After Selection and Calculation With OKULIX Completed NCT00842959 Phase 4
33 Clinical Evaluation of the One-Piece Tecnis Multifocal Intraocular Lens (IOL) Completed NCT01210807 Phase 4
34 Evaluation of 3 Intraocular Lenses Following Lens Extraction Completed NCT01122576 Phase 4
35 Clinical Evaluation of a New Aspheric Intraocular Lens. Completed NCT00786565 Phase 4
36 Visual Function Evaluation of Bilateral AcrySof ReSTOR Aspheric IOL Completed NCT00818116 Phase 4
37 Evaluation Of Bilateral Tecnis Multifocal Versus ReSTOR 3D Intraocular Lenses Completed NCT01061918 Phase 4
38 Evaluation of the Tecnis™ Multifocal and Crystalens™ Accommodating Intraocular Lenses Completed NCT01061281 Phase 4
39 Comparison of Postoperative Visual Acuity and Spectacle Independence Between the Tecnis Multifocal Intraoculer Lens (IOL) and the Crystalens Accommodating IOL Completed NCT01275118 Phase 4
40 Spherical Aberration and Contrast Sensitivity Function in Eyes Implanted With Spherical and Aspheric Intraocular Lenses: A Clinical Trial Completed NCT01028872 Phase 4
41 Light Filters in Intraocular Lenses (IOLs) and Its Influence on Colour and Contrast Vision. Completed NCT00612729 Phase 4
42 Low Cylinder Toric Completed NCT00732030 Phase 4
43 Visual Function After Implantation of Bilateral AcrySoft ReSTOR Aspheric IOL Completed NCT00934622 Phase 4
44 Visual Outcomes of Subjects Bilaterally Implanted With ReSTOR Aspheric +4 vs. Tecnis or Acri.LISA Completed NCT00721253 Phase 4
45 Contralateral ReSTOR / Monofocal or Phakic Eye Completed NCT00731640 Phase 4
46 Visual Function With Bilateral AcrySof® ReSTOR® Aspheric SN6AD1 Completed NCT00710931 Phase 4
47 Visual Function After Implantation of Bilateral AcrySof® Toric Natural Intraocular Lens Completed NCT00760487 Phase 4
48 Selection of Aspheric Diffractive Multifocal Intraocular Lens (IOLS) Based on Corneal Wavefront Completed NCT00999492 Phase 4
49 Visual Outcome, Cylinder Correction and Patient Satisfaction After Implantation of AT LISA Tri Toric 939MP Intraocular Lenses Completed NCT02985723 Phase 4
50 A Single Centre Study to Analyze Cataract Surgery Following Femtosecond Laser-Assisted and Manual Cataract Surgery Completed NCT01769313 Phase 4

Search NIH Clinical Center for Lens Disease

Cochrane evidence based reviews: lens diseases

Genetic Tests for Lens Disease

Anatomical Context for Lens Disease

MalaCards organs/tissues related to Lens Disease:

39
Eye, Endothelial, Testes, Bone, Prostate, Thyroid, Brain

Publications for Lens Disease

Articles related to Lens Disease:

id Title Authors Year
1
Concomitant progressive deafness, chronic nephritis, and ocular lens disease. ( 13950238 )
1963

Variations for Lens Disease

Expression for Lens Disease

Search GEO for disease gene expression data for Lens Disease.

Pathways for Lens Disease

GO Terms for Lens Disease

Biological processes related to Lens Disease according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.83 AKR1B1 CRYAA CRYAB FOXE3 VEGFA
2 protein stabilization GO:0050821 9.56 CRYAA CRYAB GBA3 PEX19
3 positive regulation of neuroblast proliferation GO:0002052 9.51 PAX6 VEGFA
4 negative regulation of neurogenesis GO:0050768 9.49 PAX6 PITX3
5 eye photoreceptor cell development GO:0042462 9.48 PAX6 VEGFA
6 monocyte differentiation GO:0030224 9.46 MYH9 VEGFA
7 visual perception GO:0007601 9.43 CRYAA CRYBB1 CRYGA GJA3 MIP PAX6
8 iris morphogenesis GO:0061072 9.4 FOXE3 PAX6
9 camera-type eye development GO:0043010 9.37 FOXE3 PAX6
10 cornea development in camera-type eye GO:0061303 9.32 FOXE3 PAX6
11 lens development in camera-type eye GO:0002088 9.17 CRYAB CRYGA CRYGS FOXE3 MIP PAX6
12 negative regulation of intracellular transport GO:0032387 9.16 CRYAA CRYAB

Molecular functions related to Lens Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 structural constituent of eye lens GO:0005212 9.1 CRYAA CRYAB CRYBB1 CRYGA CRYGS MIP

Sources for Lens Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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