MCID: LNS001
MIFTS: 33

Lens Subluxation malady

Summaries for Lens Subluxation

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Wikipedia:63 Ectopia lentis is a displacement or malposition of the eye\'s crystalline lens from its normal location.... more...

MalaCards based summary: Lens Subluxation, also known as subluxation of lens, is related to marfan syndrome and cataract. An important gene associated with Lens Subluxation is FBN1 (fibrillin 1), and among its related pathways are superpathway of methionine degradation and Sulfur amino acid metabolism. The compounds sulfur and p00001 have been mentioned in the context of this disorder. Affiliated tissues include eye, and related mouse phenotypes are adipose tissue and reproductive system.

Aliases & Classifications for Lens Subluxation

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 27ICD9CM, 55SNOMED-CT, 38NCIt, 33MeSH
See all sources

Lens Subluxation, Aliases & Descriptions:

Name: Lens Subluxation 9 11 43 60
 
Subluxation of Lens 9


External Ids:

Disease Ontology9 DOID:11364
ICD9CM27 379.32
NCIt38 C34772
MeSH33 D007906

Related Diseases for Lens Subluxation

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Graphical network of the top 20 diseases related to Lens Subluxation:



Diseases related to lens subluxation

Symptoms for Lens Subluxation

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Drugs & Therapeutics for Lens Subluxation

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Drug clinical trials:

Search ClinicalTrials for Lens Subluxation

Search NIH Clinical Center for Lens Subluxation

Genetic Tests for Lens Subluxation

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Anatomical Context for Lens Subluxation

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MalaCards organs/tissues related to Lens Subluxation:

31
Eye

Animal Models for Lens Subluxation or affiliated genes

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MGI Mouse Phenotypes related to Lens Subluxation:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.5RPTOR, FBN1, KCNJ12
2MP:00053898.3RPTOR, MTHFR, CBS, FBN1
3MP:00053787.6KCNJ12, FBN1, CBS, MTHFR, RPTOR
4MP:00053767.4GALT, RPTOR, MTHFR, CBS, FBN1, KCNJ12

Publications for Lens Subluxation

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Articles related to Lens Subluxation:

(show top 50)    (show all 57)
idTitleAuthorsYear
1
Recessive mutations in LEPREL1 underlie a recognizable lens subluxation phenotype. (25469533)
2015
2
Surgical management of lens subluxation in Marfan syndrome. (24698610)
2014
3
Lens Subluxation after Plasmin and SF6 Injections in Rabbit Eyes. (25397749)
2014
4
Intraocular lens subluxation in marfan syndrome. (25279020)
2014
5
Traumatic lens subluxation presenting as pseudomelanoma. (25127532)
2014
6
Sudden visual loss: intraocular lens subluxation. (25225194)
2014
7
Multiple methods of surgical treatment combined with primary IOL implantation on traumatic lens subluxation/dislocation in patients with secondary glaucoma. (24790868)
2014
8
A case of Alagille syndrome complicated by intraocular lens subluxation and rhegmatogenous retinal detachment. (23898221)
2013
9
Lens Subluxation and Retinal Dysfunction in a Girl with Homozygous VSX2 Mutation. (24001013)
2013
10
Traumatic in-the-bag intraocular lens subluxation. (24088929)
2013
11
Retrospective review of visual outcome in operated lens subluxation. (24145937)
2013
12
Comparison of clinical outcomes between iris-fixated anterior chamber intraocular lenses and scleral-fixated posterior chamber intraocular lenses in Marfan syndrome with lens subluxation. (21668788)
2012
13
Scleral fixation of standard capsular tension ring and in-the-bag intraocular lens implantation in patients with severe lens subluxation. (23053778)
2012
14
Ocular photography contest. Grand prize: anterior segment: Crystalline lens subluxation with intact zonules in patient with Marfana89s syndrome. (23281527)
2012
15
In-the-bag capsular tension ring and intraocular lens subluxation or dislocation: a series of 23 cases. (22154537)
2012
16
Congenital ocular malformations (lens subluxation, pupillary displacement, cataract, myopia) and classic galactosaemia associated with Q188R anda88/or G1391A mutations. (20222886)
2011
17
Late capsular bag contraction and intraocular lens subluxation in retinitis pigmentosa: a case report. (21320335)
2011
18
Bilateral lens subluxation in a patient with suspected Loeys-Dietz syndrome. (21478606)
2011
19
Management of traumatic crystalline lens subluxation and dislocation. (20057305)
2010
20
Red reflex mimicking lens subluxation in a child undergoing orthokeratology. (19300465)
2010
21
Treatment of severe crystalline lens subluxation. (20457402)
2010
22
Primary anterior chamber intraocular lens for the treatment of severe crystalline lens subluxation. (19781480)
2009
23
Chronic newborn primary congenital glaucoma with secondary lens subluxation. (19645394)
2009
24
Angle closure glaucoma and lens subluxation secondary to eye rubbing in a patient with mycosis fungoides. (19845227)
2009
25
Phacoemulsification using iris hooks and scleral fixation of the intraocular lens in patients with secondary glaucoma associated with lens subluxation. (17585310)
2008
26
Late-onset crystalline lens subluxation after diode laser cyclophotocoagulation. (18983561)
2008
27
Bilateral lens subluxation in a case of lipoid proteinosis. (17662444)
2007
28
Bilateral lens subluxation associated with atopic eczema. (15945013)
2005
29
Iridoschisis associated with lens subluxation. (15342034)
2004
30
Spontaneous, late, in-the-bag intraocular lens subluxation in a patient with a previous acute angle-closure glaucoma attack. (15313313)
2004
31
Iridoschisis and bilateral lens subluxation associated with periocular eczema. (14967294)
2004
32
Lens subluxation following contact transscleral cyclodiode. (12365925)
2002
33
Lens subluxation: 10-years' experience at Chang Gung Memorial Hospital, Kaohsiung. (11858394)
2001
34
Intraocular lens subluxation in a patient with facial atopic dermatitis. (11226805)
2001
35
Iridoschisis associated with lens subluxation. (11738924)
2001
36
Secondary glaucoma associated with crystalline lens subluxation. (11033403)
2000
37
Marfan syndrome, lens subluxation, and open-angle glaucoma. (10604300)
1999
38
Contusion [correction of Confusion] and lens subluxation. (9591965)
1998
39
Transformation of IR spectra of the human lens capsule due to traumatic lens subluxation and correlation with the excised and dried lens capsule under different treatments. (8145979)
1994
40
Spontaneous lens subluxation in uveitis. (2248347)
1990
41
Lens subluxation as a complication of cyclocryotherapy. (2787490)
1989
42
Neodymium:YAG laser zonulysis for treatment of lens subluxation. (2784849)
1989
43
Detection of lens subluxation in pseudoexfoliation. (3261163)
1988
44
Monocular oscillopsia secondary to lens subluxation. (3491579)
1986
45
Lens subluxation in homocystinuria. A case report. (6331704)
1984
46
Anterior chamber lens subluxation through a basal peripheral iridectomy. (6682848)
1983
47
Superior lens subluxation. (528348)
1979
48
Lens subluxation and surgical aphakia treated with photocoagulation of the iris. (5359558)
1969
49
Lens subluxation or dislocation into the vitreous after a cataract incision. (20344406)
1947
50
Extraction of Right Dislocated Lens; Subluxation of Left Lens, which shows Suspensory Ligament. (19981312)
1920

Variations for Lens Subluxation

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Expression for genes affiliated with Lens Subluxation

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Search GEO for disease gene expression data for Lens Subluxation.

Pathways for genes affiliated with Lens Subluxation

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Pathways related to Lens Subluxation according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
L-cysteine degradation I36
2-oxoisovalerate decarboxylation to isobutanoyl-CoA36
cysteine biosynthesis III (mammalia)36
2-oxobutanoate degradation I36
9.6CBS, SUOX
2
Show member pathways
9.6CBS, SUOX
3
Show member pathways
L-serine degradation36
pentose phosphate pathway (oxidative branch)36
formaldehyde oxidation II (glutathione-dependent)36
9.4MTHFR, CBS
4
Show member pathways
thioredoxin pathway36
9.4MTHFR, CBS
5
Show member pathways
One Carbon Metabolism36
dTMP de novo biosynthesis (mitochondrial)36
tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate36
Trans-sulfuration and one carbon metabolism36
methionine salvage36
Methionine metabolism58
9.4CBS, MTHFR
69.4MTHFR, CBS

Compounds for genes affiliated with Lens Subluxation

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Sources:
43Novoseek, 24HMDB, 12DrugBank
See all sources

Compounds related to Lens Subluxation according to GeneCards Suite gene sharing:

(show all 28)
idCompoundScoreTop Affiliating Genes
1sulfur439.8SUOX, CBS
2p00001439.8FBN1, MTHFR
35,10-methenyltetrahydrofolate439.8MTHFR, CBS
4methylcobalamin43 2410.8CBS, MTHFR
5b vitamins439.7CBS, MTHFR
6Pyridoxine24 1210.7MTHFR, CBS
75-methyltetrahydrofolate43 1210.7MTHFR, CBS
8betaine43 2410.7MTHFR, CBS
9methylmalonic acid43 2410.7CBS, MTHFR
10cobalamin43 2410.7MTHFR, CBS
11vitamin b6439.6MTHFR, CBS
12pyridoxal 5-phosphate439.6MTHFR, CBS
13Pyridoxal 5'-phosphate249.5MTHFR, CBS
14s-adenosylhomocysteine43 2410.5CBS, MTHFR
15uric acid43 2410.5SUOX, MTHFR
16vitamin b12439.5MTHFR, CBS
17cystathionine439.5MTHFR, CBS, FBN1
18purine43 2410.4MTHFR, CBS, SUOX
19methionine439.3GALT, MTHFR, CBS
20oligonucleotide439.3GALT, CBS, SUOX
21thymidylate439.3MTHFR, CBS
22ascorbic acid43 2410.3MTHFR, FBN1, LEPREL1
23arginine439.3FBN1, SUOX, CBS, GALT
24iron43 2410.1LEPREL1, SUOX, CBS, GALT
25p002439.1MTHFR, CBS
26homocysteine43 2410.1FBN1, SUOX, CBS, MTHFR
27cysteine438.9MTHFR, CBS, SUOX, FBN1
28serine438.2FBN1, SUOX, CBS, MTHFR, RPTOR

GO Terms for genes affiliated with Lens Subluxation

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Cellular components related to Lens Subluxation according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1basement membraneGO:00056049.6FBN1, LEPREL1
2cytosolGO:00058297.5GALT, RPTOR, MTHFR, CBS, PEX19

Biological processes related to Lens Subluxation according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1homocysteine metabolic processGO:00506679.4MTHFR, CBS
2sulfur amino acid metabolic processGO:00000969.3SUOX, CBS
3response to folic acidGO:00515939.3MTHFR, CBS
4small molecule metabolic processGO:00442818.7GALT, MTHFR, CBS, SUOX

Molecular functions related to Lens Subluxation according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1heme bindingGO:00200379.6CBS, SUOX
2modified amino acid bindingGO:00723419.1MTHFR, CBS

Products for genes affiliated with Lens Subluxation

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  • Antibodies
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Sources for Lens Subluxation

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet