Aliases & Classifications for Lens Subluxation

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Aliases & Descriptions for Lens Subluxation:

Name: Lens Subluxation 10 47 12 36 65
 
Subluxation of Lens 10

Classifications:



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Disease Ontology10 DOID:11364
ICD1027 H27.11
ICD9CM29 379.32
MeSH36 D007906
NCIt42 C34772
UMLS65 C0023316

Summaries for Lens Subluxation

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MalaCards based summary: Lens Subluxation, also known as subluxation of lens, is related to isolated ectopia lentis and candidiasis, familial, 6, autosomal dominant. An important gene associated with Lens Subluxation is FBN1 (Fibrillin 1), and among its related pathways are Folate-Alcohol and Cancer Pathway and ECM-receptor interaction. Affiliated tissues include thyroid, eye and bone, and related mouse phenotypes are pigmentation and reproductive system.

Related Diseases for Lens Subluxation

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Diseases related to Lens Subluxation via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
idRelated DiseaseScoreTop Affiliating Genes
1isolated ectopia lentis11.3
2candidiasis, familial, 6, autosomal dominant10.5CBS, MTHFR
3homocystinuria due to cbs deficiency10.5CBS, FBN1, MTHFR
4isolated growth hormone deficiency10.5CBS, FBN1, SUOX
5anophthalmos with limb anomalies10.5PAX6, VSX2
6histidine metabolism disease10.5CBS, FBN1, MTHFR
7gastric small cell carcinoma10.4CBS, GALT, MTHFR
8reticular dystrophy of the retinal pigment epithelium10.4CRYAB, PITX3
9early-onset posterior polar cataract10.4BFSP1, CRYAB
10enthesopathy10.3MTHFR, SUOX
11trochlear nerve disease10.3OPTN, PEX19
12charcot-marie-tooth disease type x10.2BFSP1, CRYAB, PITX3
13paraurethral gland cancer10.2MTHFR, OPTN, VSX2
14neonatal thyrotoxicosis10.2FBN1, OPTN, PEX19
15marfan syndrome10.1
16glaucoma 3a, primary open angle, congenital, juvenile, or adult onset10.1OPTN, PAX6
17priapism10.1OPTN, PEX19
18cataract10.1
19retinitis10.1
20vitreoretinochoroidopathy dominant10.1COL18A1, P3H2
21myopia, high, with cataract and vitreoretinal degeneration10.1
22functional diarrhea10.0OPTN, PAX6
23myopia10.0
24homocystinuria10.0
25clitoris cancer10.0OPTN, PAX6, PEX19
26knuckle pads, leuconychia and sensorineural deafness10.0ADAMTS18, COL18A1
27ametropic amblyopia9.9OPTN, PAX6
28malignant thyroid stimulating hormone producing neoplasm of pituitary gland9.9MTHFR, THBS1
29alagille syndrome9.8
30mycosis fungoides9.8
31retinitis pigmentosa9.8
32loeys-dietz syndrome9.8
33megalocornea9.8
34open-angle glaucoma9.8
35coloboma9.8
36uveitis9.8
37dermatitis9.8
38atopic dermatitis9.8
39retinal detachment9.8
40primary congenital glaucoma9.8
41homocysteinemia9.8
42mthfr deficiency9.8
43interstitial nephritis9.6PAX6, PITX3, VSX2
44cortical blindness9.6COL18A1, FBN1, P3H2, PAX6
45cerebral hemorrhage9.5BFSP1, CRYAB, GALT, P3H2, PAX6, PITX3
46ovarian disease9.3CRYAB, OPTN, PAX6, PEX19, PITX3
47congenital aphakia4.7ADAMTS18, BFSP1, CBS, COL18A1, CRYAB, FBN1

Graphical network of the top 20 diseases related to Lens Subluxation:



Diseases related to lens subluxation

Symptoms for Lens Subluxation

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Drugs & Therapeutics for Lens Subluxation

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Prospective Study of Cionni Ring and In-the-bag IOL Implantation for Subluxated LensesCompletedNCT01346566Phase 3
2Comparison of the Capsular Stability With Two Different IOL Models in Patients With Pseudoexfoliation Syndrome: an Exploratory StudyRecruitingNCT02155478
3Endothelial Cell Loss After Phacoemulsification Intra and SupracapsularActive, not recruitingNCT02535819
4Natural History of IOL in Pseudo Exfoliation SyndromeActive, not recruitingNCT01255995

Search NIH Clinical Center for Lens Subluxation


Cochrane evidence based reviews: lens subluxation

Genetic Tests for Lens Subluxation

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Anatomical Context for Lens Subluxation

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MalaCards organs/tissues related to Lens Subluxation:

33
Thyroid, Eye, Bone, Heart, Endothelial, Pituitary, Temporal lobe

Animal Models for Lens Subluxation or affiliated genes

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MGI Mouse Phenotypes related to Lens Subluxation:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.7COL18A1, FBN1, PAX6, PITX3, VSX2
2MP:00053897.7ADAMTS18, FBN1, MTHFR, PAX6, PITX3, RPTOR
3MP:00053907.1ADAMTS18, COL18A1, FBN1, MTHFR, PAX6, PITX3
4MP:00053916.9ADAMTS18, BFSP1, COL18A1, CRYAB, MTHFR, PAX6

Publications for Lens Subluxation

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Articles related to Lens Subluxation:

(show top 50)    (show all 64)
idTitleAuthorsYear
1
Homocysteinemia due to MTHFR deficiency in a young adult presenting with bilateral lens subluxations. (27046515)
2016
2
A case of iridofundal coloboma with persistent fetal vasculature and lens subluxation. (27009512)
2016
3
Recessive mutations in LEPREL1 underlie a recognizable lens subluxation phenotype. (25469533)
2015
4
Single suture iris-to-capsulorhexis fixation for in-the-bag intraocular lens subluxation. (26703481)
2015
5
Pathologic evidence of pseudoexfoliation in cases of in-the-bag intraocular lens subluxation or dislocation. (25935341)
2015
6
Surgical management of lens subluxation in Marfan syndrome. (24698610)
2014
7
Lens Subluxation after Plasmin and SF6 Injections in Rabbit Eyes. (25397749)
2014
8
Intraocular lens subluxation in marfan syndrome. (25279020)
2014
9
Traumatic lens subluxation presenting as pseudomelanoma. (25127532)
2014
10
Sudden visual loss: intraocular lens subluxation. (25225194)
2014
11
A case of Alagille syndrome complicated by intraocular lens subluxation and rhegmatogenous retinal detachment. (23898221)
2013
12
Lens Subluxation and Retinal Dysfunction in a Girl with Homozygous VSX2 Mutation. (24001013)
2013
13
Traumatic in-the-bag intraocular lens subluxation. (24088929)
2013
14
Comparison of clinical outcomes between iris-fixated anterior chamber intraocular lenses and scleral-fixated posterior chamber intraocular lenses in Marfan syndrome with lens subluxation. (21668788)
2012
15
Scleral fixation of standard capsular tension ring and in-the-bag intraocular lens implantation in patients with severe lens subluxation. (23053778)
2012
16
Ocular photography contest. Grand prize: anterior segment: Crystalline lens subluxation with intact zonules in patient with Marfana89s syndrome. (23281527)
2012
17
In-the-bag capsular tension ring and intraocular lens subluxation or dislocation: a series of 23 cases. (22154537)
2012
18
Congenital ocular malformations (lens subluxation, pupillary displacement, cataract, myopia) and classic galactosaemia associated with Q188R anda88/or G1391A mutations. (20222886)
2011
19
Late capsular bag contraction and intraocular lens subluxation in retinitis pigmentosa: a case report. (21320335)
2011
20
Bilateral lens subluxation in a patient with suspected Loeys-Dietz syndrome. (21478606)
2011
21
Management of traumatic crystalline lens subluxation and dislocation. (20057305)
2010
22
Red reflex mimicking lens subluxation in a child undergoing orthokeratology. (19300465)
2010
23
Primary anterior chamber intraocular lens for the treatment of severe crystalline lens subluxation. (19781480)
2009
24
Chronic newborn primary congenital glaucoma with secondary lens subluxation. (19645394)
2009
25
Phacoemulsification using iris hooks and scleral fixation of the intraocular lens in patients with secondary glaucoma associated with lens subluxation. (17585310)
2008
26
Late-onset crystalline lens subluxation after diode laser cyclophotocoagulation. (18983561)
2008
27
Bilateral lens subluxation in a case of lipoid proteinosis. (17662444)
2007
28
Anterior axial lens subluxation, progressive myopia, and angle-closure glaucoma: recognition and treatment of atypical presentation of ectopia lentis. (16935236)
2006
29
Iridoschisis associated with lens subluxation. (15342034)
2004
30
Spontaneous, late, in-the-bag intraocular lens subluxation in a patient with a previous acute angle-closure glaucoma attack. (15313313)
2004
31
Iridoschisis and bilateral lens subluxation associated with periocular eczema. (14967294)
2004
32
Lens subluxation following contact transscleral cyclodiode. (12365925)
2002
33
Lens subluxation: 10-years' experience at Chang Gung Memorial Hospital, Kaohsiung. (11858394)
2001
34
Intraocular lens subluxation in a patient with facial atopic dermatitis. (11226805)
2001
35
Iridoschisis associated with lens subluxation. (11738924)
2001
36
Secondary glaucoma associated with crystalline lens subluxation. (11033403)
2000
37
Marfan syndrome, lens subluxation, and open-angle glaucoma. (10604300)
1999
38
Contusion [correction of Confusion] and lens subluxation. (9591965)
1998
39
Bilateral megalocornea with unilateral lens subluxation. (9134548)
1997
40
Spontaneous lens subluxation in uveitis. (2248347)
1990
41
Lens subluxation as a complication of cyclocryotherapy. (2787490)
1989
42
Neodymium:YAG laser zonulysis for treatment of lens subluxation. (2784849)
1989
43
Detection of lens subluxation in pseudoexfoliation. (3261163)
1988
44
Monocular oscillopsia secondary to lens subluxation. (3491579)
1986
45
Lens subluxation in homocystinuria. A case report. (6331704)
1984
46
Anterior chamber lens subluxation through a basal peripheral iridectomy. (6682848)
1983
47
Superior lens subluxation. (528348)
1979
48
Lens subluxation or dislocation into the vitreous after a cataract incision. (20344406)
1947
49
Extraction of Right Dislocated Lens; Subluxation of Left Lens, which shows Suspensory Ligament. (19981312)
1920
50

Variations for Lens Subluxation

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Expression for genes affiliated with Lens Subluxation

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Search GEO for disease gene expression data for Lens Subluxation.

Pathways for genes affiliated with Lens Subluxation

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Pathways related to Lens Subluxation according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
110.0CBS, MTHFR
2
Show member pathways
8.8COL18A1, FBN1, THBS1
3
Show member pathways
7.8ADAMTS18, COL18A1, FBN1, MFAP4, P3H2, THBS1

GO Terms for genes affiliated with Lens Subluxation

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Cellular components related to Lens Subluxation according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1microfibrilGO:00015279.8FBN1, MFAP4

Biological processes related to Lens Subluxation according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1homocysteine metabolic processGO:005066710.5CBS, MTHFR
2eye developmentGO:00016549.9ADAMTS18, PAX6
3response to hypoxiaGO:00016669.2CRYAB, MTHFR, THBS1
4visual perceptionGO:00076018.7COL18A1, PAX6, VSX2

Sources for Lens Subluxation

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet