Aliases & Classifications for Lens Subluxation

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Aliases & Descriptions for Lens Subluxation:

Name: Lens Subluxation 10 47 12 36 65
 
Subluxation of Lens 10

Classifications:



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Disease Ontology10 DOID:11364
ICD1027 H27.11
ICD9CM29 379.32
MeSH36 D007906
NCIt42 C34772
UMLS65 C0023316

Summaries for Lens Subluxation

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MalaCards based summary: Lens Subluxation, also known as subluxation of lens, is related to isolated ectopia lentis and myopia, high, with cataract and vitreoretinal degeneration. An important gene associated with Lens Subluxation is FBN1 (Fibrillin 1), and among its related pathways are Folate-Alcohol and Cancer Pathway and Degradation of the extracellular matrix. Affiliated tissues include bone, endothelial and eye, and related mouse phenotypes are pigmentation and reproductive system.

Related Diseases for Lens Subluxation

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Diseases related to Lens Subluxation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 73)
idRelated DiseaseScoreTop Affiliating Genes
1isolated ectopia lentis11.7
2myopia, high, with cataract and vitreoretinal degeneration10.5
3candidiasis, familial, 6, autosomal dominant10.3CBS, MTHFR
4homocystinuria due to cbs deficiency10.3CBS, FBN1, MTHFR
5isolated growth hormone deficiency10.3CBS, FBN1, SUOX
6anophthalmos with limb anomalies10.3PAX6, VSX2
7histidine metabolism disease10.3CBS, FBN1, MTHFR
8gastric small cell carcinoma10.3CBS, GALT, MTHFR
9lung cancer10.3
10reticular dystrophy of the retinal pigment epithelium10.3CRYAB, PITX3
11early-onset posterior polar cataract10.3BFSP1, CRYAB
12enthesopathy10.2MTHFR, SUOX
13thyroiditis10.2
14trochlear nerve disease10.2OPTN, PEX19
15charcot-marie-tooth disease type x10.2BFSP1, CRYAB, PITX3
16paraurethral gland cancer10.1MTHFR, OPTN, VSX2
17neonatal thyrotoxicosis10.1FBN1, OPTN, PEX19
18glaucoma 3a, primary open angle, congenital, juvenile, or adult onset10.1OPTN, PAX6
19priapism10.1OPTN, PEX19
20neural tube defects10.1
21hepatitis c virus10.1
22otitis media10.1
23panic disorder10.1
24common variable immunodeficiency10.1
25gastric cancer10.1
26hepatitis10.1
27leukemia10.1
28silicosis10.1
29temporal lobe epilepsy10.1
30ulcerative colitis10.1
31tick-borne encephalitis10.1
32colitis10.1
33lymphoblastic leukemia10.1
34chronic adhesive otitis media10.1
35typhus10.1
36heart disease10.1
37exotropia10.1
38protein-energy malnutrition10.1
39gastroparesis10.1
40scrub typhus10.1
41congenital heart disease10.1
42hepatitis c10.1
43focal epilepsy10.1
44protein s deficiency10.1
45cervicitis10.1
46dermatitis10.1
47purpura10.1
48craniopharyngioma10.1
49coronary stenosis10.1
50occupational dermatitis10.1

Graphical network of the top 20 diseases related to Lens Subluxation:



Diseases related to lens subluxation

Symptoms for Lens Subluxation

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Drugs & Therapeutics for Lens Subluxation

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Prospective Study of Cionni Ring and In-the-bag IOL Implantation for Subluxated LensesCompletedNCT01346566Phase 3
2Comparison of the Capsular Stability With Two Different IOL Models in Patients With Pseudoexfoliation Syndrome: an Exploratory StudyRecruitingNCT02155478
3Endothelial Cell Loss After Phacoemulsification Intra and SupracapsularActive, not recruitingNCT02535819
4Natural History of IOL in Pseudo Exfoliation SyndromeActive, not recruitingNCT01255995

Search NIH Clinical Center for Lens Subluxation


Cochrane evidence based reviews: lens subluxation

Genetic Tests for Lens Subluxation

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Anatomical Context for Lens Subluxation

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MalaCards organs/tissues related to Lens Subluxation:

33
Bone, Endothelial, Eye, Liver, T cells, Bone marrow, Neutrophil

Animal Models for Lens Subluxation or affiliated genes

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MGI Mouse Phenotypes related to Lens Subluxation:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.7COL18A1, FBN1, PAX6, PITX3, VSX2
2MP:00053897.7ADAMTS18, FBN1, MTHFR, PAX6, PITX3, RPTOR
3MP:00053907.1ADAMTS18, COL18A1, FBN1, MTHFR, PAX6, PITX3
4MP:00053916.9ADAMTS18, BFSP1, COL18A1, CRYAB, MTHFR, PAX6

Publications for Lens Subluxation

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Articles related to Lens Subluxation:

(show top 50)    (show all 60)
idTitleAuthorsYear
1
Molecular Mechanism for the Control of Eukaryotic Elongation Factor 2 Kinase by pH: Role in Cancer Cell Survival. (25776553)
2015
2
Prevalence of Trachoma in Jigawa State, Northwestern Nigeria. (26158576)
2015
3
IL-17A G197A and IL-17F T7488C polymorphisms and cancer risk in Asian populations: a meta-analysis. (24965422)
2014
4
Pancytopenia in a surgical patient, a rare presentation of hyperthyroidism. (25511310)
2014
5
Laparoscopic diagnosis and treatment of a hydrocele of the canal of Nuck extending in the retroperitoneal space: A case report. (25462052)
2014
6
Consider thin basement membrane nephropathy as a possible cause of asymptomatic microscopic hematuria. (25369618)
2014
7
Loss of HER2 positivity and prognosis after neoadjuvant therapy in HER2-positive breast cancer patients. (24013581)
2013
8
Cortical thinning and clinical heterogeneity in amyotrophic lateral sclerosis. (24278317)
2013
9
Is it reasonable in strictly regulating the use of statins for treatment of patients with ischemic stroke and hyperlipidemia? (24030087)
2013
10
Aural cholesteatoma with upper neck extension. (22115754)
2012
11
Replication and pathogenicity of attenuated human metapneumovirus F mutants in severe combined immunodeficiency mice. (22085552)
2012
12
Evolutionary conservation of the tissue factor disulfide bonds and identification of a possible oxidoreductase binding motif. (22066736)
2012
13
Presumed immune-mediated hemolytic anemia in two foals with Rhodococcus equi infection. (21631714)
2011
14
I^-Catenin signaling increases during melanoma progression and promotes tumor cell survival and chemoresistance. (21858114)
2011
15
Diarrhea-related hemolytic uremic syndrome: unmasking antifactor H antibodies. (21912037)
2011
16
Do dopaminergic gene polymorphisms affect mesolimbic reward activation of music listening response? Therapeutic impact on Reward Deficiency Syndrome (RDS). (19914781)
2010
17
Type 2 diabetes risk alleles are associated with reduced size at birth. (19228808)
2009
18
Acylated ghrelin inhibits spontaneous luteinizing hormone pulsatility and responsiveness to naloxone but not that to gonadotropin-releasing hormone in young men: evidence for a central inhibitory action of ghrelin on the gonadal axis. (18559917)
2008
19
Clinical and immunologic features of pediatric patients with common variable immunodeficiency and respiratory complications. (18714533)
2008
20
Syntaxin 6, a regulator of the protein trafficking machinery and a target of the p53 family, is required for cell adhesion and survival. (18779328)
2008
21
Molecular characteristics of T-cell receptor of clonal expansion of T lymphocytes in leukemia patients after haploidentical bone marrow transplantation]. (17355783)
2007
22
Do erythropoietin receptors on cancer cells explain unexpected clinical findings? (17416869)
2007
23
Lethal fetal and early neonatal presentation of adenylosuccinate lyase deficiency: observation of 6 patients in 4 families. (17188615)
2007
24
Acetylcholinesterase inhibitors and sleep architecture in patients with Alzheimer's disease. (16872233)
2006
25
CpG oligonucleotides enhance the tumor antigen-specific immune response of an anti-idiotype antibody-based vaccine strategy in CEA transgenic mice. (16044253)
2006
26
Diverse Toll-like receptors utilize Tpl2 to activate extracellular signal-regulated kinase (ERK) in hemopoietic cells. (16484370)
2006
27
Dissecting the interferon-induced inhibition of hepatitis C virus replication by using a novel host cell line. (16227297)
2005
28
Serum and CSF vitamin A concentrations in idiopathic intracranial hypertension. (15955940)
2005
29
Increased CD8+ cytotoxic T cell responses to myelin basic protein in multiple sclerosis. (15067096)
2004
30
Expression of dominant-negative Fas-associated death domain blocks human keratinocyte apoptosis and vesication induced by sulfur mustard. (12482751)
2003
31
Delta 12-prostaglandin J2, a plasma metabolite of prostaglandin D2, causes eosinophil mobilization from the bone marrow and primes eosinophils for chemotaxis. (12707356)
2003
32
Congenital syphilis in the 21st century. (12844452)
2003
33
Activation of hemostasis in patients with chronic cholecystitis]. (11320544)
2001
34
In vitro metabolism of acitretin by human liver microsomes: evidence of an acitretinoyl-coenzyme A thioester conjugate in the transesterification to etretinate. (10874125)
2000
35
Matrix metalloproteinase-3 removes agrin from synaptic basal lamina. (10770843)
2000
36
Reflex sympathetic dystrophy in children. (10968542)
2000
37
Tight association of loss of merlin expression with loss of heterozygosity at chromosome 22q in sporadic meningiomas. (10606247)
1999
38
Transition of polycythemia vera to chronic neutrophilic leukemia. (10194140)
1999
39
Renal coccidiosis and other parasitologic conditions in lesser snow goose goslings at Tha-anne River, west coast Hudson Bay. (8827676)
1996
40
Cholesterol 7alpha-hydroxylase activities from human and rat liver are modulated in vitro posttranslationally by phosphorylation/dephosphorylation. (8938182)
1996
41
DMSA renal scans in adults with acute pyelonephritis. (8869786)
1996
42
Acute lithium treatment enhances neuropeptide Y gene expression in rat hippocampus. (1372067)
1992
43
Cell association and degradation of alpha 2-macroglobulin-trypsin complexes in hepatocytes and adipocytes. (6187372)
1983
44
Serum immunoglobulins in different stages of human intestinal schistosomiasis. (1235501)
1975
45
The treatment of blepharitis: a controlled double blind study of combination therapy. (4567181)
1973
46
Studies on the etiology of infectious atrophic rhinitis of swine. II. Agglutination test on Bordetella bronchiseptica infection. (5531793)
1970
47
Mobius' syndrome. (13778936)
1961
48
A CASE OF CHONDROMA BULBI. (18170246)
1946
49
Pathogenetical Correlations between Periarteritis Nodosa, Renal Hypertension and Rheumatic Lesions. (20322881)
1943
50

Variations for Lens Subluxation

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Expression for genes affiliated with Lens Subluxation

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Search GEO for disease gene expression data for Lens Subluxation.

Pathways for genes affiliated with Lens Subluxation

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Pathways related to Lens Subluxation according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
110.0CBS, MTHFR
2
Show member pathways
7.8ADAMTS18, COL18A1, FBN1, MFAP4, P3H2, THBS1

GO Terms for genes affiliated with Lens Subluxation

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Cellular components related to Lens Subluxation according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1microfibrilGO:00015279.8FBN1, MFAP4

Biological processes related to Lens Subluxation according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1homocysteine metabolic processGO:005066710.5CBS, MTHFR
2eye developmentGO:00016549.9ADAMTS18, PAX6
3response to hypoxiaGO:00016669.2CRYAB, MTHFR, THBS1
4visual perceptionGO:00076018.7COL18A1, PAX6, VSX2

Sources for Lens Subluxation

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet