MCID: LNS001
MIFTS: 35

Lens Subluxation malady

Summaries for Lens Subluxation

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63Wikipedia, 32MalaCards
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Wikipedia:63 Ectopia lentis is a displacement or malposition of the eye\'s crystalline lens from its normal location.... more...

MalaCards: Lens Subluxation, also known as subluxation of lens, is related to glaucoma and cataract. An important gene associated with Lens Subluxation is FBN1 (fibrillin 1), and among its related pathways are 2-oxobutanoate degradation I and Cysteine and methionine metabolism. The compounds 5,10-methenyltetrahydrofolate and methylcobalamin have been mentioned in the context of this disorder. Affiliated tissues include eye, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Lens Subluxation

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 27ICD9CM, 56SNOMED-CT, 39NCIt
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Aliases & Descriptions:

lens subluxation 8 10 44 60
subluxation of lens 8


External Ids:

Disease Ontology8 DOID:11364
MeSH34 D007906
ICD9CM27 379.32
NCIt39 C34772

Related Diseases for Lens Subluxation

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Lens Subluxation:



Diseases related to lens subluxation

Clinical Features for Lens Subluxation

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Drugs & Therapeutics for Lens Subluxation

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Lens Subluxation

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Anatomical Context for Lens Subluxation

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32MalaCards
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MalaCards organs/tissues related to Lens Subluxation:

32
Eye

Animal Models for Lens Subluxation or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Lens Subluxation:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.1CBS, LITAF, MTHFR, FBN1, GALT, KCNJ12

Publications for Lens Subluxation

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50PubMed
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Articles related to Lens Subluxation:

(show top 50)    (show all 61)
idTitleAuthorsYear
1
A case of Alagille syndrome complicated by intraocular lens subluxation and rhegmatogenous retinal detachment. (23898221)
2013
2
Lens Subluxation and Retinal Dysfunction in a Girl with Homozygous VSX2 Mutation. (24001013)
2013
3
Traumatic in-the-bag intraocular lens subluxation. (24088929)
2013
4
Evaluation of secondary glaucoma associated with subluxated lens misdiagnosed as acute primary angle-closure glaucoma. (22218127)
2013
5
Posterior iris-claw aphakic intraocular lens implantation in subluxated lenses due to Marfan syndrome. (24057936)
2013
6
Retrospective review of visual outcome in operated lens subluxation. (24145937)
2013
7
Comparison of clinical outcomes between iris-fixated anterior chamber intraocular lenses and scleral-fixated posterior chamber intraocular lenses in Marfan syndrome with lens subluxation. (21668788)
2012
8
Ocular photography contest. Grand prize: anterior segment: Crystalline lens subluxation with intact zonules in patient with Marfana89s syndrome. (23281527)
2012
9
In-the-bag capsular tension ring and intraocular lens subluxation or dislocation: a series of 23 cases. (22154537)
2012
10
Pentacam-aided diagnosis of traumatic lens subluxation. (22491583)
2012
11
Congenital ocular malformations (lens subluxation, pupillary displacement, cataract, myopia) and classic galactosaemia associated with Q188R anda88/or G1391A mutations. (20222886)
2011
12
Late capsular bag contraction and intraocular lens subluxation in retinitis pigmentosa: a case report. (21320335)
2011
13
Ophthalmic images. Traumatic anterior subluxation of natural lens with aniridia and blood lining Descemet folds. (21280250)
2011
14
Bilateral lens subluxation in a patient with suspected Loeys-Dietz syndrome. (21478606)
2011
15
Classical familial homocystinuria in an adult presenting as an isolated lens subluxation. (21626167)
2011
16
Outcomes of iris-claw anterior chamber versus iris-fixated foldable intraocular lens in subluxated lens secondary to Marfan syndrome. (20466427)
2010
17
Management of traumatic crystalline lens subluxation and dislocation. (20057305)
2010
18
Red reflex mimicking lens subluxation in a child undergoing orthokeratology. (19300465)
2010
19
Treatment of severe crystalline lens subluxation. (20457402)
2010
20
Primary anterior chamber intraocular lens for the treatment of severe crystalline lens subluxation. (19781480)
2009
21
Angle closure glaucoma and lens subluxation secondary to eye rubbing in a patient with mycosis fungoides. (19845227)
2009
22
Phacoemulsification using iris hooks and scleral fixation of the intraocular lens in patients with secondary glaucoma associated with lens subluxation. (17585310)
2008
23
Late-onset crystalline lens subluxation after diode laser cyclophotocoagulation. (18983561)
2008
24
Bilateral lens subluxation in a case of lipoid proteinosis. (17662444)
2007
25
Unilateral congenital corneal keloid with anterior segment mesenchymal dysgenesis and subluxated lens: case report and review of literature. (17198027)
2007
26
Anterior axial lens subluxation, progressive myopia, and angle-closure glaucoma: recognition and treatment of atypical presentation of ectopia lentis. (16935236)
2006
27
Bilateral lens subluxation associated with atopic eczema. (15945013)
2005
28
Iridoschisis associated with lens subluxation. (15342034)
2004
29
Spontaneous, late, in-the-bag intraocular lens subluxation in a patient with a previous acute angle-closure glaucoma attack. (15313313)
2004
30
Iridoschisis and bilateral lens subluxation associated with periocular eczema. (14967294)
2004
31
Visual results, prognostic indicators, and posterior segment findings following surgery for cataract/lens subluxation-dislocation secondary to ocular contusion injuries. (12441722)
2002
32
Intraocular lens subluxation in a patient with facial atopic dermatitis. (11226805)
2001
33
Iridoschisis associated with lens subluxation. (11738924)
2001
34
Secondary glaucoma associated with crystalline lens subluxation. (11033403)
2000
35
Marfan syndrome, lens subluxation, and open-angle glaucoma. (10604300)
1999
36
Contusion [correction of Confusion] and lens subluxation. (9591965)
1998
37
Bilateral megalocornea with unilateral lens subluxation. (9134548)
1997
38
Transformation of IR spectra of the human lens capsule due to traumatic lens subluxation and correlation with the excised and dried lens capsule under different treatments. (8145979)
1994
39
Genetic spontaneous late subluxation of the lens previously reported as a myopic kinship with primary angle closure glaucoma. (1520099)
1992
40
Spontaneous lens subluxation in uveitis. (2248347)
1990
41
Implantation of posterior chamber lenses in eyes with phakodonesis and lens subluxation. (2380931)
1990
42
Neodymium:YAG laser zonulysis for treatment of lens subluxation. (2784849)
1989
43
Detection of lens subluxation in pseudoexfoliation. (3261163)
1988
44
Monocular oscillopsia secondary to lens subluxation. (3491579)
1986
45
Lens subluxation in homocystinuria. A case report. (6331704)
1984
46
Superior lens subluxation. (528348)
1979
47
Lens subluxation and surgical aphakia treated with photocoagulation of the iris. (5359558)
1969
48
Lens subluxation or dislocation into the vitreous after a cataract incision. (20344406)
1947
49
Bilateral Buphthalmos with Congenital Anomalies of Iris and Subluxated Lens. (19992730)
1943
50
Extraction of Right Dislocated Lens; Subluxation of Left Lens, which shows Suspensory Ligament. (19981312)
1920

Genetic Variations for Lens Subluxation

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Expression for genes affiliated with Lens Subluxation

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lens Subluxation

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Pathways for genes affiliated with Lens Subluxation

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37NCBI BioSystems Database, 29KEGG, 53Reactome, 12EMD Millipore, 49PharmGKB
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Compounds for genes affiliated with Lens Subluxation

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44Novoseek, 24HMDB, 11DrugBank
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Compounds related to Lens Subluxation according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
15,10-methenyltetrahydrofolate449.8MTHFR, CBS
2methylcobalamin44 2410.8CBS, MTHFR
3p00001449.7MTHFR, FBN1
4b vitamins449.7CBS, MTHFR
5Pyridoxine11 2410.7MTHFR, CBS
65-methyltetrahydrofolate44 1110.7CBS, MTHFR
7betaine44 2410.7CBS, MTHFR
8methylmalonic acid44 2410.7MTHFR, CBS
9sulfur449.6SUOX, CBS
10cobalamin44 2410.6CBS, MTHFR
11vitamin b6449.6CBS, MTHFR
12cystathionine449.5CBS, MTHFR, FBN1
13pyridoxal 5-phosphate449.4CBS, MTHFR
14purine44 2410.4SUOX, CBS, MTHFR
15arginine449.2GALT, FBN1, CBS, SUOX
16ascorbic acid44 2410.2FBN1, MTHFR, LEPREL1
17iron44 2410.2GALT, CBS, LEPREL1, SUOX
18homocysteine44 2410.2SUOX, CBS, MTHFR, FBN1
19methionine449.1CBS, MTHFR, GALT
20serine448.0RPTOR, FBN1, MTHFR, CBS, SUOX

GO Terms for genes affiliated with Lens Subluxation

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16Gene Ontology
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Cellular components related to Lens Subluxation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:0058297.9PEX19, CBS, MTHFR, GALT, HSD17B1, RPTOR

Biological processes related to Lens Subluxation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sulfur amino acid metabolic processGO:0000969.4SUOX, CBS
2homocysteine metabolic processGO:0506679.3CBS, MTHFR
3small molecule metabolic processGO:0442818.5SUOX, CBS, MTHFR, GALT, HSD17B1

Molecular functions related to Lens Subluxation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1modified amino acid bindingGO:0723419.4CBS, MTHFR

Products for genes affiliated with Lens Subluxation

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lens Subluxation

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet