MCID: LNS001
MIFTS: 31

Lens Subluxation malady

Category: Eye diseases

Aliases & Classifications for Lens Subluxation

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Aliases & Descriptions for Lens Subluxation:

Name: Lens Subluxation 11 50 39 13 68
 
Subluxation of Lens 11 27

Classifications:



External Ids:

Disease Ontology11 DOID:11364
ICD1030 H27.11
ICD9CM32 379.32
MeSH39 D007906
NCIt45 C34772

Summaries for Lens Subluxation

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Wikipedia:71 Ectopia lentis is a displacement or malposition of the eye\'s crystalline lens from its normal location.... more...

MalaCards based summary: Lens Subluxation, also known as subluxation of lens, is related to isolated ectopia lentis and myopia, high, with cataract and vitreoretinal degeneration. An important gene associated with Lens Subluxation is FBN1 (Fibrillin 1), and among its related pathways are Carbon metabolism and One carbon pool by folate. Affiliated tissues include eye and endothelial, and related mouse phenotype Increased shRNA abundance (Z-score > 2).

Related Diseases for Lens Subluxation

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Graphical network of the top 20 diseases related to Lens Subluxation:



Diseases related to lens subluxation

Symptoms & Phenotypes for Lens Subluxation

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GenomeRNAi Phenotypes related to Lens Subluxation according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00366-A-358.5MTHFR, P3H2, VSX2

Drugs & Therapeutics for Lens Subluxation

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Prospective Study of Cionni Ring and In-the-bag IOL Implantation for Subluxated LensesCompletedNCT01346566Phase 3
2Comparison of the Capsular Stability With Two Different IOL Models in Patients With Pseudoexfoliation Syndrome: an Exploratory StudyUnknown statusNCT02155478
3Ultrasound Biomicroscopic Analysis of Cionni Ring and In-the-bag IOL Implantation for Subluxated LensesCompletedNCT02790268
4Early Vs Late Post Traumatic Cataract SurgeryCompletedNCT02900365
5Late Dislocation of Intraocular Lens (IOL) Following Cataract Surgery: an Evaluation of Two Different Surgical MethodsActive, not recruitingNCT01784926
6Endothelial Cell Loss After Phacoemulsification Intra and SupracapsularActive, not recruitingNCT02535819
7Natural History of IOL in Pseudo Exfoliation SyndromeActive, not recruitingNCT01255995

Search NIH Clinical Center for Lens Subluxation


Cochrane evidence based reviews: lens subluxation

Genetic Tests for Lens Subluxation

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Genetic tests related to Lens Subluxation:

id Genetic test Affiliating Genes
1 Lens Subluxation27

Anatomical Context for Lens Subluxation

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MalaCards organs/tissues related to Lens Subluxation:

36
Eye, Endothelial

Publications for Lens Subluxation

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Articles related to Lens Subluxation:

(show top 50)    (show all 64)
idTitleAuthorsYear
1
Homocysteinemia due to MTHFR deficiency in a young adult presenting with bilateral lens subluxations. (27046515)
2016
2
A case of iridofundal coloboma with persistent fetal vasculature and lens subluxation. (27009512)
2016
3
Unilateral fronto-temporal headache with ocular pain caused by lens subluxation due to spontaneous zonulysis. (27752586)
2015
4
Single suture iris-to-capsulorhexis fixation for in-the-bag intraocular lens subluxation. (26703481)
2015
5
Pathologic evidence of pseudoexfoliation in cases of in-the-bag intraocular lens subluxation or dislocation. (25935341)
2015
6
Recessive mutations in LEPREL1 underlie a recognizable lens subluxation phenotype. (25469533)
2015
7
Surgical management of lens subluxation in Marfan syndrome. (24698610)
2014
8
Multiple methods of surgical treatment combined with primary IOL implantation on traumatic lens subluxation/dislocation in patients with secondary glaucoma. (24790868)
2014
9
Results of fibrillin-1 gene analysis in children from inbred families with lens subluxation. (24698609)
2014
10
Lens Subluxation after Plasmin and SF6 Injections in Rabbit Eyes. (25397749)
2014
11
Intraocular lens subluxation in marfan syndrome. (25279020)
2014
12
Traumatic lens subluxation presenting as pseudomelanoma. (25127532)
2014
13
Sudden visual loss: intraocular lens subluxation. (25225194)
2014
14
A case of Alagille syndrome complicated by intraocular lens subluxation and rhegmatogenous retinal detachment. (23898221)
2013
15
Traumatic in-the-bag intraocular lens subluxation. (24088929)
2013
16
Lens subluxation with stretched ciliary processes in a girl with Goltz syndrome. (24923086)
2013
17
Lens Subluxation and Retinal Dysfunction in a Girl with Homozygous VSX2 Mutation. (24001013)
2013
18
Retrospective review of visual outcome in operated lens subluxation. (24145937)
2013
19
Scleral fixation of standard capsular tension ring and in-the-bag intraocular lens implantation in patients with severe lens subluxation. (23053778)
2012
20
Ocular photography contest. Grand prize: anterior segment: Crystalline lens subluxation with intact zonules in patient with Marfana89s syndrome. (23281527)
2012
21
Pentacam-aided diagnosis of traumatic lens subluxation. (22491583)
2012
22
Comparison of clinical outcomes between iris-fixated anterior chamber intraocular lenses and scleral-fixated posterior chamber intraocular lenses in Marfan syndrome with lens subluxation. (21668788)
2012
23
In-the-bag capsular tension ring and intraocular lens subluxation or dislocation: a series of 23 cases. (22154537)
2012
24
Congenital ocular malformations (lens subluxation, pupillary displacement, cataract, myopia) and classic galactosaemia associated with Q188R anda88/or G1391A mutations. (20222886)
2011
25
Late capsular bag contraction and intraocular lens subluxation in retinitis pigmentosa: a case report. (21320335)
2011
26
Bilateral lens subluxation in a patient with suspected Loeys-Dietz syndrome. (21478606)
2011
27
Classical familial homocystinuria in an adult presenting as an isolated lens subluxation. (21626167)
2011
28
Red reflex mimicking lens subluxation in a child undergoing orthokeratology. (19300465)
2010
29
Treatment of severe crystalline lens subluxation. (20457402)
2010
30
Management of traumatic crystalline lens subluxation and dislocation. (20057305)
2010
31
Chronic newborn primary congenital glaucoma with secondary lens subluxation. (19645394)
2009
32
Primary anterior chamber intraocular lens for the treatment of severe crystalline lens subluxation. (19781480)
2009
33
Angle closure glaucoma and lens subluxation secondary to eye rubbing in a patient with mycosis fungoides. (19845227)
2009
34
Phacoemulsification using iris hooks and scleral fixation of the intraocular lens in patients with secondary glaucoma associated with lens subluxation. (17585310)
2008
35
Bilateral intraocular lens subluxation secondary to haptic angulation. (18361996)
2008
36
Late-onset crystalline lens subluxation after diode laser cyclophotocoagulation. (18983561)
2008
37
Bilateral lens subluxation in a case of lipoid proteinosis. (17662444)
2007
38
Anterior axial lens subluxation, progressive myopia, and angle-closure glaucoma: recognition and treatment of atypical presentation of ectopia lentis. (16935236)
2006
39
Bilateral lens subluxation associated with atopic eczema. (15945013)
2005
40
Iridoschisis associated with lens subluxation. (15342034)
2004
41
Iridoschisis and bilateral lens subluxation associated with periocular eczema. (14967294)
2004
42
Spontaneous, late, in-the-bag intraocular lens subluxation in a patient with a previous acute angle-closure glaucoma attack. (15313313)
2004
43
Lens subluxation following contact transscleral cyclodiode. (12365925)
2002
44
Visual results, prognostic indicators, and posterior segment findings following surgery for cataract/lens subluxation-dislocation secondary to ocular contusion injuries. (12441722)
2002
45
Lens subluxation: 10-years' experience at Chang Gung Memorial Hospital, Kaohsiung. (11858394)
2001
46
Intraocular lens subluxation in a patient with facial atopic dermatitis. (11226805)
2001
47
Iridoschisis associated with lens subluxation. (11738924)
2001
48
Secondary glaucoma associated with crystalline lens subluxation. (11033403)
2000
49
Marfan syndrome, lens subluxation, and open-angle glaucoma. (10604300)
1999
50
Contusion [correction of Confusion] and lens subluxation. (9591965)
1998

Variations for Lens Subluxation

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Expression for genes affiliated with Lens Subluxation

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Search GEO for disease gene expression data for Lens Subluxation.

Pathways for genes affiliated with Lens Subluxation

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GO Terms for genes affiliated with Lens Subluxation

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Cellular components related to Lens Subluxation according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1basement membraneGO:00056049.4FBN1, P3H2

Biological processes related to Lens Subluxation according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1homocysteine metabolic processGO:00506679.8CBS, MTHFR
2oxidation-reduction processGO:00551148.5CBS, MTHFR, P3H2

Molecular functions related to Lens Subluxation according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1modified amino acid bindingGO:00723419.1CBS, MTHFR

Sources for Lens Subluxation

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet