MCID: LNS001
MIFTS: 32

Lens Subluxation malady

Summaries for Lens Subluxation

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Ectopia lentis is a displacement or malposition of the eye\'s crystalline lens from its normal location.... more...

MalaCards: Lens Subluxation, also known as subluxation of lens, is related to marfan syndrome and homocystinuria. An important gene associated with Lens Subluxation is FBN1 (fibrillin 1), and among its related pathways are 2-oxobutanoate degradation I and Cysteine and methionine metabolism. The compounds 5,10-methenyltetrahydrofolate and methylcobalamin have been mentioned in the context of this disorder. Related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Lens Subluxation

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 35MeSH, 27ICD9CM, 57SNOMED-CT, 40NCIt
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Aliases & Descriptions:

lens subluxation 8 10 45 61
subluxation of lens 8


External Ids:

Disease Ontology8 DOID:11364
MeSH35 D007906
ICD9CM27 379.32
NCIt40 C34772

Related Diseases for Lens Subluxation

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Lens Subluxation:



Diseases related to lens subluxation

Clinical Features for Lens Subluxation

Drugs & Therapeutics for Lens Subluxation

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Lens Subluxation

Search CenterWatch for Lens Subluxation

Genetic Tests for Lens Subluxation

Anatomical Context for Lens Subluxation

Animal Models for Lens Subluxation or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Lens Subluxation:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.1CBS, LITAF, MTHFR, FBN1, GALT, KCNJ12

Publications for Lens Subluxation

Sources:
51PubMed
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Articles related to Lens Subluxation:

(show top 50)    (show all 54)
idTitleAuthorsYear
1
Lens Subluxation and Retinal Dysfunction in a Girl with Homozygous VSX2 Mutation. (24001013)
2013
2
Retrospective review of visual outcome in operated lens subluxation. (24145937)
2013
3
Intracapsular lens extraction for the treatment of pupillary block glaucoma associated with anterior subluxation of the crystalline lens. (24348413)
2013
4
Comparison of clinical outcomes between iris-fixated anterior chamber intraocular lenses and scleral-fixated posterior chamber intraocular lenses in Marfan syndrome with lens subluxation. (21668788)
2012
5
Scleral fixation of standard capsular tension ring and in-the-bag intraocular lens implantation in patients with severe lens subluxation. (23053778)
2012
6
Ocular photography contest. Grand prize: anterior segment: Crystalline lens subluxation with intact zonules in patient with Marfana89s syndrome. (23281527)
2012
7
In-the-bag capsular tension ring and intraocular lens subluxation or dislocation: a series of 23 cases. (22154537)
2012
8
Pentacam-aided diagnosis of traumatic lens subluxation. (22491583)
2012
9
Congenital ocular malformations (lens subluxation, pupillary displacement, cataract, myopia) and classic galactosaemia associated with Q188R anda88/or G1391A mutations. (20222886)
2011
10
Late capsular bag contraction and intraocular lens subluxation in retinitis pigmentosa: a case report. (21320335)
2011
11
Ophthalmic images. Traumatic anterior subluxation of natural lens with aniridia and blood lining Descemet folds. (21280250)
2011
12
Bilateral lens subluxation in a patient with suspected Loeys-Dietz syndrome. (21478606)
2011
13
Classical familial homocystinuria in an adult presenting as an isolated lens subluxation. (21626167)
2011
14
Management of traumatic crystalline lens subluxation and dislocation. (20057305)
2010
15
Red reflex mimicking lens subluxation in a child undergoing orthokeratology. (19300465)
2010
16
Treatment of severe crystalline lens subluxation. (20457402)
2010
17
Primary anterior chamber intraocular lens for the treatment of severe crystalline lens subluxation. (19781480)
2009
18
Chronic newborn primary congenital glaucoma with secondary lens subluxation. (19645394)
2009
19
Angle closure glaucoma and lens subluxation secondary to eye rubbing in a patient with mycosis fungoides. (19845227)
2009
20
Late-onset crystalline lens subluxation after diode laser cyclophotocoagulation. (18983561)
2008
21
Bilateral intraocular lens subluxation secondary to haptic angulation. (18361996)
2008
22
Bilateral lens subluxation in a case of lipoid proteinosis. (17662444)
2007
23
Anterior axial lens subluxation, progressive myopia, and angle-closure glaucoma: recognition and treatment of atypical presentation of ectopia lentis. (16935236)
2006
24
Bilateral lens subluxation associated with atopic eczema. (15945013)
2005
25
Iridoschisis associated with lens subluxation. (15342034)
2004
26
Spontaneous, late, in-the-bag intraocular lens subluxation in a patient with a previous acute angle-closure glaucoma attack. (15313313)
2004
27
Iridoschisis and bilateral lens subluxation associated with periocular eczema. (14967294)
2004
28
Lens subluxation following contact transscleral cyclodiode. (12365925)
2002
29
Visual results, prognostic indicators, and posterior segment findings following surgery for cataract/lens subluxation-dislocation secondary to ocular contusion injuries. (12441722)
2002
30
Lens subluxation: 10-years' experience at Chang Gung Memorial Hospital, Kaohsiung. (11858394)
2001
31
Intraocular lens subluxation in a patient with facial atopic dermatitis. (11226805)
2001
32
Iridoschisis associated with lens subluxation. (11738924)
2001
33
Secondary glaucoma associated with crystalline lens subluxation. (11033403)
2000
34
Marfan syndrome, lens subluxation, and open-angle glaucoma. (10604300)
1999
35
Contusion [correction of Confusion] and lens subluxation. (9591965)
1998
36
Bilateral megalocornea with unilateral lens subluxation. (9134548)
1997
37
Transformation of IR spectra of the human lens capsule due to traumatic lens subluxation and correlation with the excised and dried lens capsule under different treatments. (8145979)
1994
38
Genetic spontaneous late subluxation of the lens previously reported as a myopic kinship with primary angle closure glaucoma. (1520099)
1992
39
Spontaneous lens subluxation in uveitis. (2248347)
1990
40
Implantation of posterior chamber lenses in eyes with phakodonesis and lens subluxation. (2380931)
1990
41
Lens subluxation as a complication of cyclocryotherapy. (2787490)
1989
42
Neodymium:YAG laser zonulysis for treatment of lens subluxation. (2784849)
1989
43
Detection of lens subluxation in pseudoexfoliation. (3261163)
1988
44
Monocular oscillopsia secondary to lens subluxation. (3491579)
1986
45
Lens subluxation in homocystinuria. A case report. (6331704)
1984
46
Anterior chamber lens subluxation through a basal peripheral iridectomy. (6682848)
1983
47
Superior lens subluxation. (528348)
1979
48
Lens subluxation and surgical aphakia treated with photocoagulation of the iris. (5359558)
1969
49
Lens subluxation or dislocation into the vitreous after a cataract incision. (20344406)
1947
50
Extraction of Right Dislocated Lens; Subluxation of Left Lens, which shows Suspensory Ligament. (19981312)
1920

Genetic Variations for Lens Subluxation

Expression for genes affiliated with Lens Subluxation

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lens Subluxation

Search GEO for disease gene expression data for Lens Subluxation.

Pathways for genes affiliated with Lens Subluxation

Sources:
38NCBI BioSystems Database, 30KEGG, 54Reactome, 12EMD Millipore, 50PharmGKB
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Compounds for genes affiliated with Lens Subluxation

Sources:
45Novoseek, 24HMDB, 11DrugBank
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Compounds related to Lens Subluxation according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
15,10-methenyltetrahydrofolate459.8MTHFR, CBS
2methylcobalamin45 2410.8CBS, MTHFR
3p00001459.7MTHFR, FBN1
4b vitamins459.7CBS, MTHFR
5Pyridoxine11 2410.7MTHFR, CBS
65-methyltetrahydrofolate45 1110.7CBS, MTHFR
7betaine45 2410.7CBS, MTHFR
8methylmalonic acid45 2410.7MTHFR, CBS
9sulfur459.6SUOX, CBS
10cobalamin45 2410.6CBS, MTHFR
11vitamin b6459.6CBS, MTHFR
12cystathionine459.5CBS, MTHFR, FBN1
13pyridoxal 5-phosphate459.4CBS, MTHFR
14purine45 2410.4SUOX, CBS, MTHFR
15arginine459.2GALT, FBN1, CBS, SUOX
16ascorbic acid45 2410.2FBN1, MTHFR, LEPREL1
17iron45 2410.2GALT, CBS, LEPREL1, SUOX
18homocysteine45 2410.2SUOX, CBS, MTHFR, FBN1
19methionine459.1CBS, MTHFR, GALT
20serine458.0RPTOR, FBN1, MTHFR, CBS, SUOX

GO Terms for genes affiliated with Lens Subluxation

Sources:
16Gene Ontology
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Cellular components related to Lens Subluxation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:0058297.9PEX19, CBS, MTHFR, GALT, HSD17B1, RPTOR

Biological processes related to Lens Subluxation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sulfur amino acid metabolic processGO:0000969.4SUOX, CBS
2homocysteine metabolic processGO:0506679.3CBS, MTHFR
3small molecule metabolic processGO:0442818.5SUOX, CBS, MTHFR, GALT, HSD17B1

Molecular functions related to Lens Subluxation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1modified amino acid bindingGO:0723419.4CBS, MTHFR

Products for genes affiliated with Lens Subluxation

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lens Subluxation

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet