MCID: LNS001
MIFTS: 39

Lens Subluxation malady

Eye diseases category

Summaries for Lens Subluxation

About this section
Sources:
66Wikipedia, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
Wikipedia:66 Ectopia lentis is a displacement or malposition of the eye\'s crystalline lens from its normal location.... more...

MalaCards: Lens Subluxation, also known as subluxation of lens, is related to glaucoma and cataract. An important gene associated with Lens Subluxation is FBN1 (fibrillin 1), and among its related pathways are superpathway of methionine degradation and Sulfur amino acid metabolism. The compounds sulfur and p00001 have been mentioned in the context of this disorder. Affiliated tissues include eye, and related mouse phenotypes are adipose tissue and reproductive system.

Aliases & Classifications for Lens Subluxation

About this section
Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 36MeSH, 28ICD9CM, 59SNOMED-CT, 41NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

lens subluxation 9 11 46 63
subluxation of lens 9


External Ids:

Disease Ontology9 DOID:11364
MeSH36 D007906
ICD9CM28 379.32
NCIt41 C34772

Related Diseases for Lens Subluxation

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Graphical network of the top 20 diseases related to Lens Subluxation:



Diseases related to lens subluxation

Symptoms for Lens Subluxation

About this section

Drugs & Therapeutics for Lens Subluxation

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Lens Subluxation

Drug clinical trials:

Search ClinicalTrials for Lens Subluxation

Search NIH Clinical Center for Lens Subluxation

Search CenterWatch for Lens Subluxation

Genetic Tests for Lens Subluxation

About this section

Anatomical Context for Lens Subluxation

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Lens Subluxation:

34
Eye

Animal Models for Lens Subluxation or affiliated genes

About this section
Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Lens Subluxation:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.5RPTOR, FBN1, KCNJ12
2MP:00053898.3RPTOR, MTHFR, CBS, FBN1
3MP:00053787.6KCNJ12, FBN1, CBS, MTHFR, RPTOR
4MP:00053767.4GALT, RPTOR, MTHFR, CBS, FBN1, KCNJ12

Publications for Lens Subluxation

About this section
Sources:
53PubMed
See all sources

Articles related to Lens Subluxation:

(show all 49)
idTitleAuthorsYear
1
A case of Alagille syndrome complicated by intraocular lens subluxation and rhegmatogenous retinal detachment. (23898221)
2013
2
Lens Subluxation and Retinal Dysfunction in a Girl with Homozygous VSX2 Mutation. (24001013)
2013
3
Traumatic in-the-bag intraocular lens subluxation. (24088929)
2013
4
Retrospective review of visual outcome in operated lens subluxation. (24145937)
2013
5
Comparison of clinical outcomes between iris-fixated anterior chamber intraocular lenses and scleral-fixated posterior chamber intraocular lenses in Marfan syndrome with lens subluxation. (21668788)
2012
6
Scleral fixation of standard capsular tension ring and in-the-bag intraocular lens implantation in patients with severe lens subluxation. (23053778)
2012
7
Ocular photography contest. Grand prize: anterior segment: Crystalline lens subluxation with intact zonules in patient with Marfana89s syndrome. (23281527)
2012
8
In-the-bag capsular tension ring and intraocular lens subluxation or dislocation: a series of 23 cases. (22154537)
2012
9
Pentacam-aided diagnosis of traumatic lens subluxation. (22491583)
2012
10
Congenital ocular malformations (lens subluxation, pupillary displacement, cataract, myopia) and classic galactosaemia associated with Q188R anda88/or G1391A mutations. (20222886)
2011
11
Late capsular bag contraction and intraocular lens subluxation in retinitis pigmentosa: a case report. (21320335)
2011
12
Bilateral lens subluxation in a patient with suspected Loeys-Dietz syndrome. (21478606)
2011
13
Classical familial homocystinuria in an adult presenting as an isolated lens subluxation. (21626167)
2011
14
Management of traumatic crystalline lens subluxation and dislocation. (20057305)
2010
15
Red reflex mimicking lens subluxation in a child undergoing orthokeratology. (19300465)
2010
16
Treatment of severe crystalline lens subluxation. (20457402)
2010
17
Primary anterior chamber intraocular lens for the treatment of severe crystalline lens subluxation. (19781480)
2009
18
Chronic newborn primary congenital glaucoma with secondary lens subluxation. (19645394)
2009
19
Angle closure glaucoma and lens subluxation secondary to eye rubbing in a patient with mycosis fungoides. (19845227)
2009
20
Phacoemulsification using iris hooks and scleral fixation of the intraocular lens in patients with secondary glaucoma associated with lens subluxation. (17585310)
2008
21
Late-onset crystalline lens subluxation after diode laser cyclophotocoagulation. (18983561)
2008
22
Bilateral intraocular lens subluxation secondary to haptic angulation. (18361996)
2008
23
Bilateral lens subluxation in a case of lipoid proteinosis. (17662444)
2007
24
Anterior axial lens subluxation, progressive myopia, and angle-closure glaucoma: recognition and treatment of atypical presentation of ectopia lentis. (16935236)
2006
25
Bilateral lens subluxation associated with atopic eczema. (15945013)
2005
26
Iridoschisis associated with lens subluxation. (15342034)
2004
27
Spontaneous, late, in-the-bag intraocular lens subluxation in a patient with a previous acute angle-closure glaucoma attack. (15313313)
2004
28
Iridoschisis and bilateral lens subluxation associated with periocular eczema. (14967294)
2004
29
Lens subluxation following contact transscleral cyclodiode. (12365925)
2002
30
Visual results, prognostic indicators, and posterior segment findings following surgery for cataract/lens subluxation-dislocation secondary to ocular contusion injuries. (12441722)
2002
31
Intraocular lens subluxation in a patient with facial atopic dermatitis. (11226805)
2001
32
Iridoschisis associated with lens subluxation. (11738924)
2001
33
Secondary glaucoma associated with crystalline lens subluxation. (11033403)
2000
34
Marfan syndrome, lens subluxation, and open-angle glaucoma. (10604300)
1999
35
Contusion [correction of Confusion] and lens subluxation. (9591965)
1998
36
Bilateral megalocornea with unilateral lens subluxation. (9134548)
1997
37
Transformation of IR spectra of the human lens capsule due to traumatic lens subluxation and correlation with the excised and dried lens capsule under different treatments. (8145979)
1994
38
Spontaneous lens subluxation in uveitis. (2248347)
1990
39
Implantation of posterior chamber lenses in eyes with phakodonesis and lens subluxation. (2380931)
1990
40
Lens subluxation as a complication of cyclocryotherapy. (2787490)
1989
41
Neodymium:YAG laser zonulysis for treatment of lens subluxation. (2784849)
1989
42
Detection of lens subluxation in pseudoexfoliation. (3261163)
1988
43
Monocular oscillopsia secondary to lens subluxation. (3491579)
1986
44
Lens subluxation in homocystinuria. A case report. (6331704)
1984
45
Anterior chamber lens subluxation through a basal peripheral iridectomy. (6682848)
1983
46
Superior lens subluxation. (528348)
1979
47
Lens subluxation and surgical aphakia treated with photocoagulation of the iris. (5359558)
1969
48
Lens subluxation or dislocation into the vitreous after a cataract incision. (20344406)
1947
49
Extraction of Right Dislocated Lens; Subluxation of Left Lens, which shows Suspensory Ligament. (19981312)
1920

Variations for Lens Subluxation

About this section

Expression for genes affiliated with Lens Subluxation

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Lens Subluxation

Search GEO for disease gene expression data for Lens Subluxation.

Pathways for genes affiliated with Lens Subluxation

About this section
Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 31KEGG, 52PharmGKB, 61Thomson Reuters
See all sources

Pathways related to Lens Subluxation according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
L-cysteine degradation I39
2-oxoisovalerate decarboxylation to isobutanoyl-CoA39
cysteine biosynthesis III (mammalia)39
2-oxobutanoate degradation I39
9.6CBS, SUOX
2
Show member pathways
9.6CBS, SUOX
3
Show member pathways
L-serine degradation39
pentose phosphate pathway (oxidative branch)39
formaldehyde oxidation II (glutathione-dependent)39
9.4MTHFR, CBS
4
Show member pathways
thioredoxin pathway39
9.4MTHFR, CBS
5
Show member pathways
One Carbon Metabolism39
dTMP de novo biosynthesis (mitochondrial)39
tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate39
Trans-sulfuration and one carbon metabolism39
methionine salvage39
Methionine metabolism61
9.4CBS, MTHFR
69.4MTHFR, CBS

Compounds for genes affiliated with Lens Subluxation

About this section
Sources:
46Novoseek, 25HMDB, 12DrugBank
See all sources

Compounds related to Lens Subluxation according to GeneCards/GeneDecks:

(show all 28)
idCompoundScoreTop Affiliating Genes
1sulfur469.8SUOX, CBS
2p00001469.8FBN1, MTHFR
35,10-methenyltetrahydrofolate469.8MTHFR, CBS
4methylcobalamin46 2510.8CBS, MTHFR
5b vitamins469.7CBS, MTHFR
6Pyridoxine25 1210.7MTHFR, CBS
75-methyltetrahydrofolate46 1210.7MTHFR, CBS
8betaine46 2510.7MTHFR, CBS
9methylmalonic acid46 2510.7CBS, MTHFR
10cobalamin46 2510.7MTHFR, CBS
11vitamin b6469.6MTHFR, CBS
12pyridoxal 5-phosphate469.6MTHFR, CBS
13Pyridoxal 5'-phosphate259.5MTHFR, CBS
14s-adenosylhomocysteine46 2510.5CBS, MTHFR
15uric acid46 2510.5SUOX, MTHFR
16vitamin b12469.5MTHFR, CBS
17cystathionine469.5MTHFR, CBS, FBN1
18purine46 2510.4MTHFR, CBS, SUOX
19methionine469.3GALT, MTHFR, CBS
20oligonucleotide469.3GALT, CBS, SUOX
21thymidylate469.3MTHFR, CBS
22ascorbic acid46 2510.3MTHFR, FBN1, LEPREL1
23arginine469.3FBN1, SUOX, CBS, GALT
24iron46 2510.1LEPREL1, SUOX, CBS, GALT
25p002469.1MTHFR, CBS
26homocysteine46 2510.1FBN1, SUOX, CBS, MTHFR
27cysteine468.9MTHFR, CBS, SUOX, FBN1
28serine468.2FBN1, SUOX, CBS, MTHFR, RPTOR

GO Terms for genes affiliated with Lens Subluxation

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Lens Subluxation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basement membraneGO:0056049.6FBN1, LEPREL1
2cytosolGO:0058297.5GALT, RPTOR, MTHFR, CBS, PEX19

Biological processes related to Lens Subluxation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1homocysteine metabolic processGO:0506679.4MTHFR, CBS
2sulfur amino acid metabolic processGO:0000969.3SUOX, CBS
3response to folic acidGO:0515939.3MTHFR, CBS
4small molecule metabolic processGO:0442818.7GALT, MTHFR, CBS, SUOX

Molecular functions related to Lens Subluxation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heme bindingGO:0200379.6CBS, SUOX
2modified amino acid bindingGO:0723419.1MTHFR, CBS

Products for genes affiliated with Lens Subluxation

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lens Subluxation

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet