MCID: LNS001
MIFTS: 40

Lens Subluxation malady

Eye diseases category
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Summaries for Lens Subluxation

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Wikipedia:65 Ectopia lentis is a displacement or malposition of the eye\'s crystalline lens from its normal location.... more...

MalaCards based summary: Lens Subluxation, also known as subluxation of lens, is related to marfan syndrome and cataract. An important gene associated with Lens Subluxation is FBN1 (fibrillin 1), and among its related pathways are superpathway of methionine degradation and Sulfur amino acid metabolism. The compounds sulfur and p00001 have been mentioned in the context of this disorder. Affiliated tissues include eye, and related mouse phenotypes are adipose tissue and reproductive system.

Aliases & Classifications for Lens Subluxation

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 57SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM
See all sources

Lens Subluxation, Aliases & Descriptions:

Name: Lens Subluxation 8 10 44 62
 
Subluxation of Lens 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


External Ids:

Disease Ontology8 DOID:11364
MeSH34 D007906
NCIt39 C34772
ICD9CM27 379.32

Related Diseases for Lens Subluxation

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Graphical network of the top 20 diseases related to Lens Subluxation:



Diseases related to lens subluxation

Symptoms for Lens Subluxation

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Drugs & Therapeutics for Lens Subluxation

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Drug clinical trials:

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Search NIH Clinical Center for Lens Subluxation

Genetic Tests for Lens Subluxation

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Anatomical Context for Lens Subluxation

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MalaCards organs/tissues related to Lens Subluxation:

32
Eye

Animal Models for Lens Subluxation or affiliated genes

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MGI Mouse Phenotypes related to Lens Subluxation:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.5RPTOR, FBN1, KCNJ12
2MP:00053898.3RPTOR, MTHFR, CBS, FBN1
3MP:00053787.6KCNJ12, FBN1, CBS, MTHFR, RPTOR
4MP:00053767.4GALT, RPTOR, MTHFR, CBS, FBN1, KCNJ12

Publications for Lens Subluxation

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Articles related to Lens Subluxation:

(show top 50)    (show all 57)
idTitleAuthorsYear
1
Surgical management of lens subluxation in Marfan syndrome. (24698610)
2014
2
Lens Subluxation after Plasmin and SF6 Injections in Rabbit Eyes. (25397749)
2014
3
Intraocular lens subluxation in marfan syndrome. (25279020)
2014
4
Traumatic lens subluxation presenting as pseudomelanoma. (25127532)
2014
5
Sudden visual loss: intraocular lens subluxation. (25225194)
2014
6
Multiple methods of surgical treatment combined with primary IOL implantation on traumatic lens subluxation/dislocation in patients with secondary glaucoma. (24790868)
2014
7
A case of Alagille syndrome complicated by intraocular lens subluxation and rhegmatogenous retinal detachment. (23898221)
2013
8
Lens Subluxation and Retinal Dysfunction in a Girl with Homozygous VSX2 Mutation. (24001013)
2013
9
Traumatic in-the-bag intraocular lens subluxation. (24088929)
2013
10
Retrospective review of visual outcome in operated lens subluxation. (24145937)
2013
11
Comparison of clinical outcomes between iris-fixated anterior chamber intraocular lenses and scleral-fixated posterior chamber intraocular lenses in Marfan syndrome with lens subluxation. (21668788)
2012
12
Scleral fixation of standard capsular tension ring and in-the-bag intraocular lens implantation in patients with severe lens subluxation. (23053778)
2012
13
Ocular photography contest. Grand prize: anterior segment: Crystalline lens subluxation with intact zonules in patient with Marfana89s syndrome. (23281527)
2012
14
In-the-bag capsular tension ring and intraocular lens subluxation or dislocation: a series of 23 cases. (22154537)
2012
15
Congenital ocular malformations (lens subluxation, pupillary displacement, cataract, myopia) and classic galactosaemia associated with Q188R anda88/or G1391A mutations. (20222886)
2011
16
Late capsular bag contraction and intraocular lens subluxation in retinitis pigmentosa: a case report. (21320335)
2011
17
Bilateral lens subluxation in a patient with suspected Loeys-Dietz syndrome. (21478606)
2011
18
Management of traumatic crystalline lens subluxation and dislocation. (20057305)
2010
19
Red reflex mimicking lens subluxation in a child undergoing orthokeratology. (19300465)
2010
20
Treatment of severe crystalline lens subluxation. (20457402)
2010
21
Primary anterior chamber intraocular lens for the treatment of severe crystalline lens subluxation. (19781480)
2009
22
Chronic newborn primary congenital glaucoma with secondary lens subluxation. (19645394)
2009
23
Phacoemulsification using iris hooks and scleral fixation of the intraocular lens in patients with secondary glaucoma associated with lens subluxation. (17585310)
2008
24
Late-onset crystalline lens subluxation after diode laser cyclophotocoagulation. (18983561)
2008
25
Bilateral lens subluxation in a case of lipoid proteinosis. (17662444)
2007
26
Anterior axial lens subluxation, progressive myopia, and angle-closure glaucoma: recognition and treatment of atypical presentation of ectopia lentis. (16935236)
2006
27
Bilateral lens subluxation associated with atopic eczema. (15945013)
2005
28
Iridoschisis associated with lens subluxation. (15342034)
2004
29
Spontaneous, late, in-the-bag intraocular lens subluxation in a patient with a previous acute angle-closure glaucoma attack. (15313313)
2004
30
Iridoschisis and bilateral lens subluxation associated with periocular eczema. (14967294)
2004
31
Lens subluxation following contact transscleral cyclodiode. (12365925)
2002
32
Lens subluxation: 10-years' experience at Chang Gung Memorial Hospital, Kaohsiung. (11858394)
2001
33
Intraocular lens subluxation in a patient with facial atopic dermatitis. (11226805)
2001
34
Iridoschisis associated with lens subluxation. (11738924)
2001
35
Secondary glaucoma associated with crystalline lens subluxation. (11033403)
2000
36
Marfan syndrome, lens subluxation, and open-angle glaucoma. (10604300)
1999
37
Contusion [correction of Confusion] and lens subluxation. (9591965)
1998
38
Bilateral megalocornea with unilateral lens subluxation. (9134548)
1997
39
Transformation of IR spectra of the human lens capsule due to traumatic lens subluxation and correlation with the excised and dried lens capsule under different treatments. (8145979)
1994
40
Spontaneous lens subluxation in uveitis. (2248347)
1990
41
Lens subluxation as a complication of cyclocryotherapy. (2787490)
1989
42
Neodymium:YAG laser zonulysis for treatment of lens subluxation. (2784849)
1989
43
Detection of lens subluxation in pseudoexfoliation. (3261163)
1988
44
Monocular oscillopsia secondary to lens subluxation. (3491579)
1986
45
Lens subluxation in homocystinuria. A case report. (6331704)
1984
46
Anterior chamber lens subluxation through a basal peripheral iridectomy. (6682848)
1983
47
Superior lens subluxation. (528348)
1979
48
Lens subluxation and surgical aphakia treated with photocoagulation of the iris. (5359558)
1969
49
Lens subluxation or dislocation into the vitreous after a cataract incision. (20344406)
1947
50
Extraction of Right Dislocated Lens; Subluxation of Left Lens, which shows Suspensory Ligament. (19981312)
1920

Variations for Lens Subluxation

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Expression for genes affiliated with Lens Subluxation

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Expression patterns in normal tissues for genes affiliated with Lens Subluxation

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Pathways for genes affiliated with Lens Subluxation

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Pathways related to Lens Subluxation according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
L-cysteine degradation I37
2-oxoisovalerate decarboxylation to isobutanoyl-CoA37
cysteine biosynthesis III (mammalia)37
2-oxobutanoate degradation I37
9.6CBS, SUOX
2
Show member pathways
9.6CBS, SUOX
3
Show member pathways
L-serine degradation37
pentose phosphate pathway (oxidative branch)37
formaldehyde oxidation II (glutathione-dependent)37
9.4MTHFR, CBS
4
Show member pathways
thioredoxin pathway37
9.4MTHFR, CBS
5
Show member pathways
One Carbon Metabolism37
dTMP de novo biosynthesis (mitochondrial)37
tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate37
Trans-sulfuration and one carbon metabolism37
methionine salvage37
Methionine metabolism60
9.4CBS, MTHFR
69.4MTHFR, CBS

Compounds for genes affiliated with Lens Subluxation

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Sources:
44Novoseek, 24HMDB, 11DrugBank
See all sources

Compounds related to Lens Subluxation according to GeneCards/GeneDecks:

(show all 28)
idCompoundScoreTop Affiliating Genes
1sulfur449.8SUOX, CBS
2p00001449.8FBN1, MTHFR
35,10-methenyltetrahydrofolate449.8MTHFR, CBS
4methylcobalamin44 2410.8CBS, MTHFR
5b vitamins449.7CBS, MTHFR
6Pyridoxine24 1110.7MTHFR, CBS
75-methyltetrahydrofolate44 1110.7MTHFR, CBS
8betaine44 2410.7MTHFR, CBS
9methylmalonic acid44 2410.7CBS, MTHFR
10cobalamin44 2410.7MTHFR, CBS
11vitamin b6449.6MTHFR, CBS
12pyridoxal 5-phosphate449.6MTHFR, CBS
13Pyridoxal 5'-phosphate249.5MTHFR, CBS
14s-adenosylhomocysteine44 2410.5CBS, MTHFR
15uric acid44 2410.5SUOX, MTHFR
16vitamin b12449.5MTHFR, CBS
17cystathionine449.5MTHFR, CBS, FBN1
18purine44 2410.4MTHFR, CBS, SUOX
19methionine449.3GALT, MTHFR, CBS
20oligonucleotide449.3GALT, CBS, SUOX
21thymidylate449.3MTHFR, CBS
22ascorbic acid44 2410.3MTHFR, FBN1, LEPREL1
23arginine449.3FBN1, SUOX, CBS, GALT
24iron44 2410.1LEPREL1, SUOX, CBS, GALT
25p002449.1MTHFR, CBS
26homocysteine44 2410.1FBN1, SUOX, CBS, MTHFR
27cysteine448.9MTHFR, CBS, SUOX, FBN1
28serine448.2FBN1, SUOX, CBS, MTHFR, RPTOR

GO Terms for genes affiliated with Lens Subluxation

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Cellular components related to Lens Subluxation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basement membraneGO:0056049.6FBN1, LEPREL1
2cytosolGO:0058297.5GALT, RPTOR, MTHFR, CBS, PEX19

Biological processes related to Lens Subluxation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1homocysteine metabolic processGO:0506679.4MTHFR, CBS
2sulfur amino acid metabolic processGO:0000969.3SUOX, CBS
3response to folic acidGO:0515939.3MTHFR, CBS
4small molecule metabolic processGO:0442818.7GALT, MTHFR, CBS, SUOX

Molecular functions related to Lens Subluxation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heme bindingGO:0200379.6CBS, SUOX
2modified amino acid bindingGO:0723419.1MTHFR, CBS

Products for genes affiliated with Lens Subluxation

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  • Antibodies
  • Proteins
  • Lysates

Sources for Lens Subluxation

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet