MCID: LNS001
MIFTS: 38

Lens Subluxation malady

Summaries for Lens Subluxation

About this section


Wikipedia:65 Ectopia lentis is a displacement or malposition of the eye\'s crystalline lens from its normal location.... more...

MalaCards based summary: Lens Subluxation, also known as subluxation of lens, is related to marfan syndrome and cataract. An important gene associated with Lens Subluxation is FBN1 (fibrillin 1), and among its related pathways are superpathway of methionine degradation and Sulfur amino acid metabolism. The compounds sulfur and p00001 have been mentioned in the context of this disorder. Affiliated tissues include eye, and related mouse phenotypes are adipose tissue and reproductive system.

Aliases & Classifications for Lens Subluxation

About this section
Sources:
10Disease Ontology, 12DISEASES, 45Novoseek, 62UMLS, 29ICD9CM, 57SNOMED-CT, 40NCIt, 35MeSH
See all sources

Lens Subluxation, Aliases & Descriptions:

Name: Lens Subluxation 10 12 45 62
 
Subluxation of Lens 10 62


External Ids:

Disease Ontology10 DOID:11364
ICD9CM29 379.32
NCIt40 C34772
MeSH35 D007906

Related Diseases for Lens Subluxation

About this section

Graphical network of the top 20 diseases related to Lens Subluxation:



Diseases related to lens subluxation

Symptoms for Lens Subluxation

About this section

Drugs & Therapeutics for Lens Subluxation

About this section

Drug clinical trials:

Search ClinicalTrials for Lens Subluxation

Search NIH Clinical Center for Lens Subluxation

Genetic Tests for Lens Subluxation

About this section

Anatomical Context for Lens Subluxation

About this section

MalaCards organs/tissues related to Lens Subluxation:

33
Eye

Animal Models for Lens Subluxation or affiliated genes

About this section

MGI Mouse Phenotypes related to Lens Subluxation:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.5RPTOR, FBN1, KCNJ12
2MP:00053898.3RPTOR, MTHFR, CBS, FBN1
3MP:00053787.6KCNJ12, FBN1, CBS, MTHFR, RPTOR
4MP:00053767.4GALT, RPTOR, MTHFR, CBS, FBN1, KCNJ12

Publications for Lens Subluxation

About this section

Articles related to Lens Subluxation:

(show top 50)    (show all 57)
idTitleAuthorsYear
1
Recessive mutations in LEPREL1 underlie a recognizable lens subluxation phenotype. (25469533)
2015
2
Surgical management of lens subluxation in Marfan syndrome. (24698610)
2014
3
Lens Subluxation after Plasmin and SF6 Injections in Rabbit Eyes. (25397749)
2014
4
Intraocular lens subluxation in marfan syndrome. (25279020)
2014
5
Traumatic lens subluxation presenting as pseudomelanoma. (25127532)
2014
6
Sudden visual loss: intraocular lens subluxation. (25225194)
2014
7
Multiple methods of surgical treatment combined with primary IOL implantation on traumatic lens subluxation/dislocation in patients with secondary glaucoma. (24790868)
2014
8
A case of Alagille syndrome complicated by intraocular lens subluxation and rhegmatogenous retinal detachment. (23898221)
2013
9
Lens Subluxation and Retinal Dysfunction in a Girl with Homozygous VSX2 Mutation. (24001013)
2013
10
Traumatic in-the-bag intraocular lens subluxation. (24088929)
2013
11
Retrospective review of visual outcome in operated lens subluxation. (24145937)
2013
12
Comparison of clinical outcomes between iris-fixated anterior chamber intraocular lenses and scleral-fixated posterior chamber intraocular lenses in Marfan syndrome with lens subluxation. (21668788)
2012
13
Scleral fixation of standard capsular tension ring and in-the-bag intraocular lens implantation in patients with severe lens subluxation. (23053778)
2012
14
Ocular photography contest. Grand prize: anterior segment: Crystalline lens subluxation with intact zonules in patient with Marfana89s syndrome. (23281527)
2012
15
In-the-bag capsular tension ring and intraocular lens subluxation or dislocation: a series of 23 cases. (22154537)
2012
16
Congenital ocular malformations (lens subluxation, pupillary displacement, cataract, myopia) and classic galactosaemia associated with Q188R anda88/or G1391A mutations. (20222886)
2011
17
Late capsular bag contraction and intraocular lens subluxation in retinitis pigmentosa: a case report. (21320335)
2011
18
Bilateral lens subluxation in a patient with suspected Loeys-Dietz syndrome. (21478606)
2011
19
Management of traumatic crystalline lens subluxation and dislocation. (20057305)
2010
20
Red reflex mimicking lens subluxation in a child undergoing orthokeratology. (19300465)
2010
21
Treatment of severe crystalline lens subluxation. (20457402)
2010
22
Primary anterior chamber intraocular lens for the treatment of severe crystalline lens subluxation. (19781480)
2009
23
Chronic newborn primary congenital glaucoma with secondary lens subluxation. (19645394)
2009
24
Angle closure glaucoma and lens subluxation secondary to eye rubbing in a patient with mycosis fungoides. (19845227)
2009
25
Phacoemulsification using iris hooks and scleral fixation of the intraocular lens in patients with secondary glaucoma associated with lens subluxation. (17585310)
2008
26
Late-onset crystalline lens subluxation after diode laser cyclophotocoagulation. (18983561)
2008
27
Bilateral lens subluxation in a case of lipoid proteinosis. (17662444)
2007
28
Bilateral lens subluxation associated with atopic eczema. (15945013)
2005
29
Iridoschisis associated with lens subluxation. (15342034)
2004
30
Spontaneous, late, in-the-bag intraocular lens subluxation in a patient with a previous acute angle-closure glaucoma attack. (15313313)
2004
31
Iridoschisis and bilateral lens subluxation associated with periocular eczema. (14967294)
2004
32
Lens subluxation following contact transscleral cyclodiode. (12365925)
2002
33
Lens subluxation: 10-years' experience at Chang Gung Memorial Hospital, Kaohsiung. (11858394)
2001
34
Intraocular lens subluxation in a patient with facial atopic dermatitis. (11226805)
2001
35
Iridoschisis associated with lens subluxation. (11738924)
2001
36
Secondary glaucoma associated with crystalline lens subluxation. (11033403)
2000
37
Marfan syndrome, lens subluxation, and open-angle glaucoma. (10604300)
1999
38
Contusion [correction of Confusion] and lens subluxation. (9591965)
1998
39
Transformation of IR spectra of the human lens capsule due to traumatic lens subluxation and correlation with the excised and dried lens capsule under different treatments. (8145979)
1994
40
Spontaneous lens subluxation in uveitis. (2248347)
1990
41
Lens subluxation as a complication of cyclocryotherapy. (2787490)
1989
42
Neodymium:YAG laser zonulysis for treatment of lens subluxation. (2784849)
1989
43
Detection of lens subluxation in pseudoexfoliation. (3261163)
1988
44
Monocular oscillopsia secondary to lens subluxation. (3491579)
1986
45
Lens subluxation in homocystinuria. A case report. (6331704)
1984
46
Anterior chamber lens subluxation through a basal peripheral iridectomy. (6682848)
1983
47
Superior lens subluxation. (528348)
1979
48
Lens subluxation and surgical aphakia treated with photocoagulation of the iris. (5359558)
1969
49
Lens subluxation or dislocation into the vitreous after a cataract incision. (20344406)
1947
50
Extraction of Right Dislocated Lens; Subluxation of Left Lens, which shows Suspensory Ligament. (19981312)
1920

Variations for Lens Subluxation

About this section

Expression for genes affiliated with Lens Subluxation

About this section

Search GEO for disease gene expression data for Lens Subluxation.

Pathways for genes affiliated with Lens Subluxation

About this section

Pathways related to Lens Subluxation according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
L-cysteine degradation I38
2-oxoisovalerate decarboxylation to isobutanoyl-CoA38
cysteine biosynthesis III (mammalia)38
2-oxobutanoate degradation I38
9.6CBS, SUOX
2
Show member pathways
9.6CBS, SUOX
3
Show member pathways
L-serine degradation38
pentose phosphate pathway (oxidative branch)38
formaldehyde oxidation II (glutathione-dependent)38
9.4MTHFR, CBS
4
Show member pathways
thioredoxin pathway38
9.4MTHFR, CBS
5
Show member pathways
One Carbon Metabolism38
dTMP de novo biosynthesis (mitochondrial)38
tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate38
Trans-sulfuration and one carbon metabolism38
methionine salvage38
Methionine metabolism60
9.4CBS, MTHFR
69.4MTHFR, CBS

Compounds for genes affiliated with Lens Subluxation

About this section
Sources:
45Novoseek, 26HMDB, 13DrugBank
See all sources

Compounds related to Lens Subluxation according to GeneCards/GeneDecks:

(show all 28)
idCompoundScoreTop Affiliating Genes
1sulfur459.8SUOX, CBS
2p00001459.8FBN1, MTHFR
35,10-methenyltetrahydrofolate459.8MTHFR, CBS
4methylcobalamin45 2610.8CBS, MTHFR
5b vitamins459.7CBS, MTHFR
6Pyridoxine26 1310.7MTHFR, CBS
75-methyltetrahydrofolate45 1310.7MTHFR, CBS
8betaine45 2610.7MTHFR, CBS
9methylmalonic acid45 2610.7CBS, MTHFR
10cobalamin45 2610.7MTHFR, CBS
11vitamin b6459.6MTHFR, CBS
12pyridoxal 5-phosphate459.6MTHFR, CBS
13Pyridoxal 5'-phosphate269.5MTHFR, CBS
14s-adenosylhomocysteine45 2610.5CBS, MTHFR
15uric acid45 2610.5SUOX, MTHFR
16vitamin b12459.5MTHFR, CBS
17cystathionine459.5MTHFR, CBS, FBN1
18purine45 2610.4MTHFR, CBS, SUOX
19methionine459.3GALT, MTHFR, CBS
20oligonucleotide459.3GALT, CBS, SUOX
21thymidylate459.3MTHFR, CBS
22ascorbic acid45 2610.3MTHFR, FBN1, LEPREL1
23arginine459.3FBN1, SUOX, CBS, GALT
24iron45 2610.1LEPREL1, SUOX, CBS, GALT
25p002459.1MTHFR, CBS
26homocysteine45 2610.1FBN1, SUOX, CBS, MTHFR
27cysteine458.9MTHFR, CBS, SUOX, FBN1
28serine458.2FBN1, SUOX, CBS, MTHFR, RPTOR

GO Terms for genes affiliated with Lens Subluxation

About this section

Cellular components related to Lens Subluxation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basement membraneGO:00056049.6FBN1, LEPREL1
2cytosolGO:00058297.5GALT, RPTOR, MTHFR, CBS, PEX19

Biological processes related to Lens Subluxation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1homocysteine metabolic processGO:00506679.4MTHFR, CBS
2sulfur amino acid metabolic processGO:00000969.3SUOX, CBS
3response to folic acidGO:00515939.3MTHFR, CBS
4small molecule metabolic processGO:00442818.7GALT, MTHFR, CBS, SUOX

Molecular functions related to Lens Subluxation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heme bindingGO:00200379.6CBS, SUOX
2modified amino acid bindingGO:00723419.1MTHFR, CBS

Products for genes affiliated with Lens Subluxation

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Lens Subluxation

About this section
4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet