MCID: LNS001
MIFTS: 30

Lens Subluxation malady

Categories: Eye diseases

Aliases & Classifications for Lens Subluxation

Aliases & Descriptions for Lens Subluxation:

Name: Lens Subluxation 12 52 42 14 69
Subluxation of Lens 12 29

Classifications:



External Ids:

Disease Ontology 12 DOID:11364
ICD10 33 H27.11
ICD9CM 35 379.32
MeSH 42 D007906
NCIt 47 C34772
UMLS 69 C0023316

Summaries for Lens Subluxation

MalaCards based summary : Lens Subluxation, also known as subluxation of lens, is related to isolated ectopia lentis and myopia, high, with cataract and vitreoretinal degeneration. An important gene associated with Lens Subluxation is FBN1 (Fibrillin 1), and among its related pathways/superpathways are One carbon pool by folate and Folate-Alcohol and Cancer Pathway. Affiliated tissues include eye, and related phenotype is Increased shRNA abundance (Z-score > 2).

Wikipedia : 71 Ectopia lentis is a displacement or malposition of the eye\'s crystalline lens from its normal location.... more...

Related Diseases for Lens Subluxation

Diseases related to Lens Subluxation via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
id Related Disease Score Top Affiliating Genes
1 isolated ectopia lentis 11.7
2 myopia, high, with cataract and vitreoretinal degeneration 10.9
3 glaucoma 1, open angle, n 10.0 FBN1 MTHFR
4 marfan syndrome 10.0
5 acute poststreptococcal glomerulonephritis 10.0 MTHFR VSX2
6 johnson hall krous syndrome 10.0 CBS FBN1
7 cataract 9.9
8 retinitis 9.9
9 tmem231-related meckel syndrome 9.9 CBS FBN1
10 myh7-related myosin storage myopathy 9.9 CBS MTHFR
11 mass syndrome 9.9 CBS FBN1
12 clubfoot 9.9 FBN1 P3H2
13 nystagmus 2, congenital, autosomal dominant 9.9 CBS MTHFR
14 autosomal dominant sideroblastic anemia 9.9 CBS MTHFR
15 homocystinuria 9.9
16 myopia 9.9
17 borderline glaucoma 9.9 CBS MTHFR
18 immunodeficiency, common variable, 6 9.8 CBS MTHFR
19 neurofibroma of the heart 9.8 CBS MTHFR
20 cervix small cell carcinoma 9.8 CBS MTHFR
21 posterior uveal melanoma 9.8 CBS MTHFR
22 myosclerosis, congenital 9.7 CBS FBN1 MTHFR
23 houlston ironton temple syndrome 9.7 CBS FBN1 MTHFR
24 cleft lip 9.7 CBS FBN1 MTHFR
25 primary congenital glaucoma 9.7
26 homocysteinemia 9.7
27 alagille syndrome 9.7
28 mycosis fungoides 9.7
29 mthfr deficiency 9.7
30 megalocornea 9.7
31 headache 9.7
32 retinitis pigmentosa 9.7
33 loeys-dietz syndrome 9.7
34 open-angle glaucoma 9.7
35 uveitis 9.7
36 dermatitis 9.7
37 atopic dermatitis 9.7
38 retinal detachment 9.7
39 anal spasm 9.2 CBS FBN1 GALT MTHFR P3H2 VSX2

Graphical network of the top 20 diseases related to Lens Subluxation:



Diseases related to Lens Subluxation

Symptoms & Phenotypes for Lens Subluxation

GenomeRNAi Phenotypes related to Lens Subluxation according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.47 VSX2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.47 MTHFR
3 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.47 P3H2 VSX2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.47 P3H2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.47 MTHFR P3H2 VSX2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.47 MTHFR
7 Increased shRNA abundance (Z-score > 2) GR00366-A-6 9.47 MTHFR
8 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.47 MTHFR
9 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.47 MTHFR
10 Increased shRNA abundance (Z-score > 2) GR00366-A-82 9.47 P3H2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.47 VSX2

Drugs & Therapeutics for Lens Subluxation

Interventional clinical trials:


id Name Status NCT ID Phase
1 Prospective Study of Cionni Ring and In-the-bag IOL Implantation for Subluxated Lenses Completed NCT01346566 Phase 3
2 Comparison of the Capsular Stability With Two Different IOL Models in Patients With Pseudoexfoliation Syndrome: an Exploratory Study Unknown status NCT02155478
3 Ultrasound Biomicroscopic Analysis of Cionni Ring and In-the-bag IOL Implantation for Subluxated Lenses Completed NCT02790268
4 Early Vs Late Post Traumatic Cataract Surgery Completed NCT02900365
5 Late Dislocation of Intraocular Lens (IOL) Following Cataract Surgery: an Evaluation of Two Different Surgical Methods Active, not recruiting NCT01784926
6 Endothelial Cell Loss After Phacoemulsification Intra and Supracapsular Active, not recruiting NCT02535819
7 Natural History of IOL in Pseudo Exfoliation Syndrome Active, not recruiting NCT01255995

Search NIH Clinical Center for Lens Subluxation

Cochrane evidence based reviews: lens subluxation

Genetic Tests for Lens Subluxation

Genetic tests related to Lens Subluxation:

id Genetic test Affiliating Genes
1 Lens Subluxation 29

Anatomical Context for Lens Subluxation

MalaCards organs/tissues related to Lens Subluxation:

39
Eye

Publications for Lens Subluxation

Articles related to Lens Subluxation:

(show top 50) (show all 64)
id Title Authors Year
1
A case of iridofundal coloboma with persistent fetal vasculature and lens subluxation. ( 27009512 )
2016
2
Homocysteinemia due to MTHFR deficiency in a young adult presenting with bilateral lens subluxations. ( 27046515 )
2016
3
Recessive mutations in LEPREL1 underlie a recognizable lens subluxation phenotype. ( 25469533 )
2015
4
Single suture iris-to-capsulorhexis fixation for in-the-bag intraocular lens subluxation. ( 26703481 )
2015
5
Unilateral fronto-temporal headache with ocular pain caused by lens subluxation due to spontaneous zonulysis. ( 27752586 )
2015
6
Pathologic evidence of pseudoexfoliation in cases of in-the-bag intraocular lens subluxation or dislocation. ( 25935341 )
2015
7
Intraocular lens subluxation in marfan syndrome. ( 25279020 )
2014
8
Surgical management of lens subluxation in Marfan syndrome. ( 24698610 )
2014
9
Lens Subluxation after Plasmin and SF6 Injections in Rabbit Eyes. ( 25397749 )
2014
10
Multiple methods of surgical treatment combined with primary IOL implantation on traumatic lens subluxation/dislocation in patients with secondary glaucoma. ( 24790868 )
2014
11
Traumatic lens subluxation presenting as pseudomelanoma. ( 25127532 )
2014
12
Results of fibrillin-1 gene analysis in children from inbred families with lens subluxation. ( 24698609 )
2014
13
Sudden visual loss: intraocular lens subluxation. ( 25225194 )
2014
14
Retrospective review of visual outcome in operated lens subluxation. ( 24145937 )
2013
15
A case of Alagille syndrome complicated by intraocular lens subluxation and rhegmatogenous retinal detachment. ( 23898221 )
2013
16
Lens Subluxation and Retinal Dysfunction in a Girl with Homozygous VSX2 Mutation. ( 24001013 )
2013
17
Traumatic in-the-bag intraocular lens subluxation. ( 24088929 )
2013
18
Lens subluxation with stretched ciliary processes in a girl with Goltz syndrome. ( 24923086 )
2013
19
Ocular photography contest. Grand prize: anterior segment: Crystalline lens subluxation with intact zonules in patient with Marfana89s syndrome. ( 23281527 )
2012
20
In-the-bag capsular tension ring and intraocular lens subluxation or dislocation: a series of 23 cases. ( 22154537 )
2012
21
Comparison of clinical outcomes between iris-fixated anterior chamber intraocular lenses and scleral-fixated posterior chamber intraocular lenses in Marfan syndrome with lens subluxation. ( 21668788 )
2012
22
Scleral fixation of standard capsular tension ring and in-the-bag intraocular lens implantation in patients with severe lens subluxation. ( 23053778 )
2012
23
Pentacam-aided diagnosis of traumatic lens subluxation. ( 22491583 )
2012
24
Bilateral lens subluxation in a patient with suspected Loeys-Dietz syndrome. ( 21478606 )
2011
25
Congenital ocular malformations (lens subluxation, pupillary displacement, cataract, myopia) and classic galactosaemia associated with Q188R anda88/or G1391A mutations. ( 20222886 )
2011
26
Classical familial homocystinuria in an adult presenting as an isolated lens subluxation. ( 21626167 )
2011
27
Late capsular bag contraction and intraocular lens subluxation in retinitis pigmentosa: a case report. ( 21320335 )
2011
28
Management of traumatic crystalline lens subluxation and dislocation. ( 20057305 )
2010
29
Red reflex mimicking lens subluxation in a child undergoing orthokeratology. ( 19300465 )
2010
30
Treatment of severe crystalline lens subluxation. ( 20457402 )
2010
31
Primary anterior chamber intraocular lens for the treatment of severe crystalline lens subluxation. ( 19781480 )
2009
32
Chronic newborn primary congenital glaucoma with secondary lens subluxation. ( 19645394 )
2009
33
Angle closure glaucoma and lens subluxation secondary to eye rubbing in a patient with mycosis fungoides. ( 19845227 )
2009
34
Late-onset crystalline lens subluxation after diode laser cyclophotocoagulation. ( 18983561 )
2008
35
Phacoemulsification using iris hooks and scleral fixation of the intraocular lens in patients with secondary glaucoma associated with lens subluxation. ( 17585310 )
2008
36
Bilateral intraocular lens subluxation secondary to haptic angulation. ( 18361996 )
2008
37
Bilateral lens subluxation in a case of lipoid proteinosis. ( 17662444 )
2007
38
Anterior axial lens subluxation, progressive myopia, and angle-closure glaucoma: recognition and treatment of atypical presentation of ectopia lentis. ( 16935236 )
2006
39
Bilateral lens subluxation associated with atopic eczema. ( 15945013 )
2005
40
Iridoschisis associated with lens subluxation. ( 15342034 )
2004
41
Spontaneous, late, in-the-bag intraocular lens subluxation in a patient with a previous acute angle-closure glaucoma attack. ( 15313313 )
2004
42
Iridoschisis and bilateral lens subluxation associated with periocular eczema. ( 14967294 )
2004
43
Lens subluxation following contact transscleral cyclodiode. ( 12365925 )
2002
44
Visual results, prognostic indicators, and posterior segment findings following surgery for cataract/lens subluxation-dislocation secondary to ocular contusion injuries. ( 12441722 )
2002
45
Lens subluxation: 10-years' experience at Chang Gung Memorial Hospital, Kaohsiung. ( 11858394 )
2001
46
Intraocular lens subluxation in a patient with facial atopic dermatitis. ( 11226805 )
2001
47
Iridoschisis associated with lens subluxation. ( 11738924 )
2001
48
Secondary glaucoma associated with crystalline lens subluxation. ( 11033403 )
2000
49
Marfan syndrome, lens subluxation, and open-angle glaucoma. ( 10604300 )
1999
50
Contusion [correction of Confusion] and lens subluxation. ( 9591965 )
1998

Variations for Lens Subluxation

Expression for Lens Subluxation

Search GEO for disease gene expression data for Lens Subluxation.

Pathways for Lens Subluxation

GO Terms for Lens Subluxation

Cellular components related to Lens Subluxation according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 basement membrane GO:0005604 8.62 FBN1 P3H2

Biological processes related to Lens Subluxation according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.13 CBS MTHFR P3H2
2 homocysteine metabolic process GO:0050667 8.62 CBS MTHFR

Molecular functions related to Lens Subluxation according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 modified amino acid binding GO:0072341 8.62 CBS MTHFR

Sources for Lens Subluxation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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