LMM
MCID: LNT002
MIFTS: 40

Lentigo Maligna Melanoma (LMM) malady

Rare diseases category
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Summaries for Lentigo Maligna Melanoma

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NIH Rare Diseases:42 Lentigo maligna melanoma (lmm) is a type of skin cancer that usually develops in older, fair-skinned adults.  the average age of diagnosis is 65.  lmm is thought to be caused by a history of sun exposure to the affected area.  treatment includes surgery to remove as much of the lmm as possible. last updated: 11/23/2012

MalaCards based summary: Lentigo Maligna Melanoma, also known as hutchinson's melanotic freckle, is related to melanoma and basal cell carcinoma. An important gene associated with Lentigo Maligna Melanoma is NKX2-1 (NK2 homeobox 1), and among its related pathways are Angiogenesis and AGE/RAGE pathway. The compounds mucicarmine and b 723 have been mentioned in the context of this disorder. Affiliated tissues include skin, and related mouse phenotypes are integument and skeleton.

Wikipedia:65 Lentigo maligna melanoma is a melanoma that has evolved from a lentigo maligna. They are usually found... more...

Aliases & Classifications for Lentigo Maligna Melanoma

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Lentigo Maligna Melanoma, Aliases & Descriptions:

Name: Lentigo Maligna Melanoma 42 62
Hutchinson's Melanotic Freckle 62
 
Hutchison Melanotic Freckle 42
Lmm 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Lentigo Maligna Melanoma

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Diseases related to Lentigo Maligna Melanoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1melanoma30.9MLANA, MMP9, MITF, NKX2-1, MMP2, S100B
2basal cell carcinoma10.6
3superficial spreading melanoma10.6
4meningioma10.4S100B
5burns10.4
6skin disease10.4
7acral lentiginous melanoma10.4
8gastrointestinal stromal tumor10.4
9xeroderma pigmentosum10.4
10merkel cell carcinoma10.4
11dermatomyositis10.4
12keratosis10.4
13seborrheic keratosis10.4
14cutaneous malignant melanoma10.4
15juvenile xanthogranuloma10.2MLANA, S100B
16granular cell tumor10.2MLANA, S100B
17sex cord-gonadal stromal tumor10.2NKX2-1, S100B
18perivascular epithelioid cell tumor10.2MITF, MLANA
19leiomyosarcoma10.2MLANA, S100B
20neuroendocrine carcinoma10.2S100B, NKX2-1
21angiomyolipoma10.2MITF, MLANA
22vitiligo10.2MLANA, MITF
23clear cell sarcoma10.2S100B, MITF
24fibrous histiocytoma10.1S100B, MITF
25malignant peripheral nerve sheath tumor10.1MITF, S100B
26neurofibroma10.1MITF, S100B
27stroke, ischemic10.1S100B, MMP9
28lymphangioleiomyomatosis10.1MLANA, MMP2
29neurilemmoma10.1MITF, S100B
30tongue cancer10.1MMP9, MMP2
31conjunctivochalasis10.1MMP2, MMP9
32abdominal aortic aneurysm10.0MMP2, MMP9
33keratitis10.0MMP2, MMP9
34bladder carcinoma in situ10.0MMP9, MMP2
35aneurysm10.0MMP9, MMP2
36grade iii astrocytoma10.0MMP9, MMP2
37microphthalmia10.0S100B, MLANA, MITF
38periodontal disease10.0MMP9, MMP2
39giant cell tumor9.9MMP9, MITF, S100B
40oral cancer9.9MMP2, MMP9
41pulmonary fibrosis9.9MMP9, MMP2
42fibrosarcoma9.9MLANA, MMP2, MMP9
43congenital heart disease9.9MMP9, MMP2
44lung adenocarcinoma9.9MMP9, MMP2, NKX2-1
45endometrial carcinoma9.9MMP9, MMP2, NKX2-1
46colorectal cancer9.8MMP9, MMP2, NKX2-1
47non-small cell lung carcinoma9.8MMP9, NKX2-1, MMP2
48astrocytoma9.8S100B, MMP9, MMP2
49glioblastoma9.8S100B, MMP2, MMP9
50breast cancer9.8MMP9, NKX2-1, MMP2

Graphical network of the top 20 diseases related to Lentigo Maligna Melanoma:



Diseases related to lentigo maligna melanoma

Symptoms for Lentigo Maligna Melanoma

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Drugs & Therapeutics for Lentigo Maligna Melanoma

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Drug clinical trials:

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Genetic Tests for Lentigo Maligna Melanoma

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Anatomical Context for Lentigo Maligna Melanoma

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MalaCards organs/tissues related to Lentigo Maligna Melanoma:

32
Skin

Animal Models for Lentigo Maligna Melanoma or affiliated genes

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MGI Mouse Phenotypes related to Lentigo Maligna Melanoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.2S100B, MITF, MMP9, MLANA
2MP:00053907.8NKX2-1, MITF, MMP2, MMP9

Publications for Lentigo Maligna Melanoma

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Articles related to Lentigo Maligna Melanoma:

(show top 50)    (show all 116)
idTitleAuthorsYear
1
Lentigo maligna and lentigo maligna melanoma as occupational skin diseases in a forestry worker with long-standing occupational UV-exposure. (24903264)
2014
2
Delineating Margins of Lentigo Maligna (Melanoma) Using a Hyperspectral Imaging System. (25394551)
2014
3
Johnson square procedure for lentigo maligna and lentigo maligna melanoma. (24934910)
2014
4
Distribution of MC1R variants among melanoma subtypes: p.R163Q is associated with lentigo maligna melanoma in a Mediterranean population. (23647022)
2013
5
KIT and BRAF mutational status in a patient with a synchronous lentigo maligna melanoma and a gastrointestinal stromal tumor. (22175303)
2012
6
Lentigo maligna melanoma--the review. (21305747)
2010
7
Matrix metalloproteinases 2 and 9 in lentigo maligna melanoma. (19528914)
2009
8
Staged excision versus Mohs micrographic surgery for lentigo maligna and lentigo maligna melanoma. (17870430)
2007
9
Progression of lentigo maligna into lentigo maligna melanoma following laser treatment. (17478397)
2007
10
Hypomyopathic dermatomyositis associated with lentigo maligna melanoma. (16781317)
2006
11
A collision tumor involving Basal cell carcinoma and lentigo maligna melanoma. (16121053)
2005
12
Management of lentigo maligna and lentigo maligna melanoma with staged excision: a 5-year follow-up. (15148099)
2004
13
Lentigo maligna melanoma. (15624713)
2004
14
A comparison of dermoscopic features among lentigo senilis/initial seborrheic keratosis, seborrheic keratosis, lentigo maligna and lentigo maligna melanoma on the face. (15729860)
2004
15
Surgical margins for lentigo maligna and lentigo maligna melanoma: the technique of mapped serial excision. (15381549)
2004
16
Amelanotic lentigo maligna melanoma. (14724412)
2004
17
Management of early lentigo maligna and lentigo maligna melanoma of the head and neck. (15062292)
2003
18
Parasitism of basal cell carcinoma by lentigo maligna melanoma. (12734489)
2003
19
Topical treatment of lentigo maligna melanoma with imiquimod 5% cream. (14571081)
2003
20
Ultraviolet-assisted punch biopsy mapping for lentigo maligna melanoma. (11352422)
2001
21
Fractionated radiotherapy of lentigo maligna and lentigo maligna melanoma in 64 patients. (10954659)
2000
22
Lentigo maligna melanoma. (10865932)
2000
23
Amelanotic lentigo maligna melanoma: a unique case presentation. (10469082)
1999
24
Amelanotic lentigo maligna melanoma: report of a case and review of the literature. (10431675)
1999
25
Lentigo maligna melanoma and excisional biopsy techniques. (10088870)
1999
26
Mohs micrographic surgery for lentigo maligna and lentigo maligna melanoma. A follow-up study. (9648576)
1998
27
Extrafacial lentigo maligna melanoma: analysis of 71 cases and comparison with lentigo maligna melanoma of the head and neck. (9767288)
1998
28
Lentigo maligna and lentigo maligna melanoma. (9091498)
1997
29
Lentigo maligna and lentigo maligna melanoma. (9204053)
1997
30
Comparison between lentigo maligna melanoma and other histogenetic types of malignant melanoma of the head and neck. Scottish Melanoma Group. (8611411)
1996
31
Cytodiagnosis of pulmonary metastatic malignant melanoma from lentigo maligna melanoma. (7669930)
1995
32
Amelanotic lentigo maligna melanoma. (7829736)
1995
33
Management of lentigo maligna and lentigo maligna melanoma with tangential paraffin-embedded sections. (8089308)
1994
34
Successful treatment of lentigo maligna and lentigo maligna melanoma with Mohs' micrographic surgery aided by rush permanent sections. (8199993)
1994
35
Angiocentric invasion by lentigo maligna melanoma. (8132839)
1994
36
Management of lentigo maligna and lentigo maligna melanoma with paraffin-embedded tangential sections: utility of immunoperoxidase staining and supplemental vertical sections. (8408795)
1993
37
Metastatic lentigo maligna melanoma. (2299024)
1990
38
The risk of progression of lentigo maligna to lentigo maligna melanoma. (3567069)
1987
39
Microinvasive lentigo maligna melanoma. (3312317)
1987
40
Lentigo maligna melanoma with deep invasion along the mental nerve. (3459796)
1986
41
Lentigo maligna melanoma yields to radiotherapy. (6848821)
1983
42
Conventional fractionated radiotherapy for 51 patients with lentigo maligna and lentigo maligna melanoma. (6863069)
1983
43
Amelanotic lentigo maligna melanoma manifesting as a dermatitislike plaque. (6847222)
1983
44
Treatment of lentigo maligna and lentigo maligna melanoma. (7391322)
1980
45
The radiotherapy of lentigo maligna and lentigo maligna melanoma of the head and neck. (7379026)
1980
46
Tumor conference 21. Lentigo maligna melanoma. (762304)
1979
47
Pagetoid malignant melanoma and lentigo maligna melanoma of toe. A study with the fluorescence method (Falck and Hillarp). (718255)
1978
48
Proceedings: Lentigo-maligna melanoma: an ultrastructural study. (1276041)
1976
49
Tyrosinase activity in three types of the malignant melanoma: superficial spreading melanoma, lentigo maligna melanoma and nodular melanoma. (50762)
1975
50
Lentigo maligna and lentigo-maligna melanoma. (5776171)
1969

Variations for Lentigo Maligna Melanoma

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Expression for genes affiliated with Lentigo Maligna Melanoma

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Expression patterns in normal tissues for genes affiliated with Lentigo Maligna Melanoma

Search GEO for disease gene expression data for Lentigo Maligna Melanoma.

Pathways for genes affiliated with Lentigo Maligna Melanoma

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Compounds for genes affiliated with Lentigo Maligna Melanoma

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Compounds related to Lentigo Maligna Melanoma according to GeneCards/GeneDecks:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1mucicarmine4410.0NKX2-1, S100B
2b 723449.9S100B, NKX2-1
3cgs-27023a449.5MMP9, MMP2
4flavanol449.5MMP9, MMP2
5col 3449.5MMP2, MMP9
6methyl selenol449.5MMP9, MMP2
7prinomastat449.5MMP2, MMP9
8trapidil449.5MMP2, MMP9
9ilomastat449.5MMP9, MMP2
10lercanidipine44 1110.5MMP9, MMP2
11tranilast449.5MMP2, MMP9
12gelfoam449.4MMP9, MMP2
13cilomilast449.4MMP9, MMP2
14latanoprost44 1110.4MMP9, MMP2
15(4-aminophenyl)mercuric acetate449.4MMP2, MMP9
16gm 6001619.4MMP2, MMP9
17uk 383367619.4MMP2, MMP9
18gi 254023x619.4MMP9, MMP2
19hydroxamate449.4MMP2, MMP9
20marimastat44 61 1111.4MMP2, MMP9
21zoledronic acid449.4MMP9, MMP2
22ciglitazone44 2810.3MMP9, MMP2
238-isoprostane449.3MMP2, MMP9
241,10-phenanthroline44 210.3MMP9, MMP2
25ns 39844 6110.3MMP2, MMP9
26batimastat44 61 1111.3MMP2, MMP9
27silymarin449.2MMP9, MMP2
28formaldehyde44 2410.2NKX2-1, S100B, MMP9
29hydroxyproline44 24 1111.1MMP2, MMP9
30cyclic amp44 2410.1MITF, S100B, NKX2-1
31ivig449.0MMP2, MMP9
323-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.0MMP2, S100B, MMP9
33ribonucleic acid449.0MMP9, MMP2, NKX2-1
34erythromycin44 2 50 1111.9MMP2, MMP9
35norepinephrine44 24 1110.9MMP2, S100B, MMP9
36wortmannin448.9MMP2, S100B, MMP9
3712-o-tetradecanoylphorbol 13-acetate448.9MITF, MMP2, MMP9
38proline448.8S100B, MMP9, MMP2
39creatinine448.8S100B, MMP9, MMP2
40ribavirin44 50 1110.7MMP2, MMP9
41aspartate448.7MMP2, S100B, MMP9
42hematoxylin448.7MLANA, MMP9, NKX2-1, S100B
43zinc44 249.6NKX2-1, MMP9, MMP2, S100B
44estrogen448.5S100B, MMP9, NKX2-1, MMP2
45retinoic acid44 249.5S100B, NKX2-1, MMP9, MMP2
46lactate448.5MLANA, MMP9, MMP2, S100B
47glutamate448.4MMP9, S100B, MITF, MMP2
48serine448.3MMP2, MMP9, S100B, NKX2-1
49tyrosine448.1MMP2, MITF, S100B, NKX2-1, MMP9
50paraffin447.6NKX2-1, MMP9, MMP2, MITF, S100B, MLANA

GO Terms for genes affiliated with Lentigo Maligna Melanoma

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Biological processes related to Lentigo Maligna Melanoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix disassemblyGO:0226179.0MMP2, MMP9
2embryo implantationGO:0075668.9MMP2, MMP9
3collagen catabolic processGO:0305748.7MMP2, MMP9

Molecular functions related to Lentigo Maligna Melanoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityGO:0037059.2NKX2-1, MITF
2metalloendopeptidase activityGO:0042229.0MMP2, MMP9
3protein bindingGO:0055157.0S100B, MLANA, MMP9, MMP2, MITF, NKX2-1

Products for genes affiliated with Lentigo Maligna Melanoma

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Sources for Lentigo Maligna Melanoma

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3CDC
13ExPASy
14FMA
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24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
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36MGI
39NCIt
40NDF-RT
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44Novoseek
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47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet