MCID: LNT002
MIFTS: 34

Lentigo Maligna Melanoma

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Lentigo Maligna Melanoma

MalaCards integrated aliases for Lentigo Maligna Melanoma:

Name: Lentigo Maligna Melanoma 50 69
Hutchison Melanotic Freckle 50
Lmm 50

Classifications:



Summaries for Lentigo Maligna Melanoma

NIH Rare Diseases : 50 lentigo maligna melanoma (lmm) is a type of skin cancer that usually develops in older, fair-skinned adults.  the average age of diagnosis is 65.  lmm is thought to be caused by a history of sun exposure to the affected area.  treatment includes surgery to remove as much of the lmm as possible. last updated: 11/23/2012

MalaCards based summary : Lentigo Maligna Melanoma, also known as hutchison melanotic freckle, is related to melanoma and endocervical type cervical adenomyoma. An important gene associated with Lentigo Maligna Melanoma is MC1R (Melanocortin 1 Receptor), and among its related pathways/superpathways are Pathways in cancer and Matrix Metalloproteinases. The drugs Aminolevulinic acid and Dermatologic Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, and related phenotypes are integument and pigmentation

Wikipedia : 72 Lentigo maligna melanoma is a melanoma that has evolved from a lentigo maligna. They are usually found... more...

Related Diseases for Lentigo Maligna Melanoma

Diseases related to Lentigo Maligna Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 75)
id Related Disease Score Top Affiliating Genes
1 melanoma 11.1
2 endocervical type cervical adenomyoma 10.3 MITF MLANA
3 sebaceous basal cell carcinoma 10.3 MITF MLANA
4 schnitzler syndrome 10.3 MITF MLANA
5 thyroid angiosarcoma 10.3 MITF MLANA
6 fasciolopsiasis 10.3 MC1R MMP2
7 dubin-johnson syndrome 10.3 MC1R MITF
8 basal cell carcinoma 10.2
9 superficial spreading melanoma 10.2
10 kidney hypertrophy 10.2 MITF S100B
11 kidney sarcoma 10.1 MITF S100B
12 phobic disorder 10.1 MLANA S100B
13 gastrointestinal stromal tumor 10.0
14 burns 10.0
15 skin disease 10.0
16 dermatomyositis 10.0
17 keratosis 10.0
18 squamous cell carcinoma 10.0
19 merkel cell carcinoma 10.0
20 acral lentiginous melanoma 10.0
21 facial arteriovenous malformation 10.0 MMP2 MMP9
22 familial short qt syndrome 10.0 MMP2 MMP9
23 kleptomania 10.0 MMP2 MMP9
24 acquired hemangioma 10.0 MMP2 MMP9
25 transitional meningioma 10.0 MMP2 MMP9
26 drug rash with eosinophilia and systemic symptoms 10.0 MMP2 MMP9
27 tinea profunda 10.0 MMP2 MMP9
28 xanthogranulomatous cholecystitis 10.0 MMP2 MMP9
29 collagenous colitis 9.9 MMP2 MMP9
30 sialadenitis 9.9 MMP2 MMP9
31 corneal staphyloma 9.9 MMP2 MMP9
32 limbic encephalitis 9.9 MMP2 MMP9
33 heavy chain disease 9.9 MC1R MITF MLANA
34 spindle epithelial tumor with thymus-like differentiation tumor 9.9 MMP2 MMP9
35 nasal cavity adenocarcinoma 9.9 MMP2 MMP9
36 ulnar neuropathy 9.9 MMP2 MMP9
37 adenosine monophosphate deaminase 1 deficiency 9.9 MMP2 MMP9
38 charcot-marie-tooth disease, axonal, type 2cc 9.9 MMP2 MMP9
39 influenza 9.9 MMP2 MMP9
40 tricho onychic dysplasia 9.9 MMP2 MMP9
41 lung papillary adenocarcinoma 9.9 MMP2 MMP9
42 rare endometriosis 9.9 MMP2 MMP9
43 laryngostenosis 9.9 MMP2 MMP9
44 cystitis 9.9 MMP2 MMP9
45 mastoiditis 9.9 MMP2 MMP9
46 bladder urachal squamous cell carcinoma 9.9 MLANA S100B
47 hodgkin's lymphoma, mixed cellularity 9.8 MMP2 MMP9
48 pulmonary subvalvular stenosis 9.8 MMP2 MMP9
49 trachea squamous cell carcinoma 9.8 MMP2 MMP9
50 orbital lymphangioma 9.8 MMP2 MMP9

Graphical network of the top 20 diseases related to Lentigo Maligna Melanoma:



Diseases related to Lentigo Maligna Melanoma

Symptoms & Phenotypes for Lentigo Maligna Melanoma

MGI Mouse Phenotypes related to Lentigo Maligna Melanoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.35 MC1R MITF MLANA MMP9 S100B
2 pigmentation MP:0001186 8.8 MC1R MITF MLANA

Drugs & Therapeutics for Lentigo Maligna Melanoma

Drugs for Lentigo Maligna Melanoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aminolevulinic acid Approved Phase 4 106-60-5 137
2 Dermatologic Agents Phase 4
3 Photosensitizing Agents Phase 4
4
Imiquimod Approved, Investigational Phase 3,Phase 2 99011-02-6 57469
5 Adjuvants, Immunologic Phase 3,Phase 2
6 Interferon Inducers Phase 3,Phase 2
7 interferons Phase 3,Phase 2
8
Cediranib Investigational Phase 2 288383-20-0 9933475
9
Maleic acid Experimental Phase 2 110-16-7 444266
10 Protein Kinase Inhibitors Phase 2
11
Ganciclovir Approved, Investigational Phase 1 82410-32-0 3454
12 Anti-Infective Agents Phase 1
13 Antiviral Agents Phase 1
14 Ganciclovir triphosphate Phase 1
15 Nucleic Acid Synthesis Inhibitors Phase 1

Interventional clinical trials:

(show all 12)

id Name Status NCT ID Phase Drugs
1 Photodynamic Therapy for Lentigo Maligna Using 5-aminolevulinic Acid Nanoemulsion as a Light Sensitizing Cream Recruiting NCT02685592 Phase 4 5-aminolevulinic acid nanoemulsion
2 Relevance of Imiquimod as Neo-adjuvant Treatment to Reduce Excision Size and the Risk of Intralesional Excision in Lentigo Malignant of the Face Recruiting NCT01720407 Phase 3 Imiquimod cream + surgery;Placebo + surgery
3 Imiquimod to Detect Residual Lesions and Prevent Recurrence of Lentigo Maligna Recruiting NCT01088737 Phase 2, Phase 3 Imiquimod
4 Radiotherapy or Imiquimod in Complex Lentigo Maligna Recruiting NCT02394132 Phase 3 Imiquimod
5 AZD2171 in Treating Patients With Recurrent or Stage IV Melanoma Completed NCT00243061 Phase 2 cediranib maleate
6 Prospective Study of Ingenol Mebutate for Non-invasive Lentigo Melanoma of the Face Recruiting NCT02723721 Phase 2 Picato gel
7 Dinaciclib in Treating Patients With Stage IV Melanoma Active, not recruiting NCT00937937 Phase 2 Dinaciclib
8 Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Stage IV Melanoma Terminated NCT01120275 Phase 2 gamma-secretase/Notch signalling pathway inhibitor RO4929097
9 Gene Therapy and Ganciclovir in Treating Patients With Stage IV Melanoma Completed NCT00005057 Phase 1 ganciclovir
10 In Vivo Confocal Microscopy for Pigmented Lesion Diagnosis Completed NCT00785369
11 Study of Families With Melanoma Recruiting NCT00445783
12 Mohs and Immunofluorescence for Malignant Melanoma In Situ Withdrawn NCT02306512

Search NIH Clinical Center for Lentigo Maligna Melanoma

Genetic Tests for Lentigo Maligna Melanoma

Anatomical Context for Lentigo Maligna Melanoma

MalaCards organs/tissues related to Lentigo Maligna Melanoma:

39
Skin

Publications for Lentigo Maligna Melanoma

Articles related to Lentigo Maligna Melanoma:

(show top 50) (show all 132)
id Title Authors Year
1
Very Rare Amelanotic Lentigo Maligna Melanoma with Skull Roof Invasion. ( 28785332 )
2017
2
Amelanotic Lentigo Maligna Melanoma: Mohs Surgery as the Definitive Treatment of an Invisible Tumour. ( 28685596 )
2017
3
Synchronous conjunctival melanoma and lentigo maligna melanoma. ( 28954115 )
2017
4
Locally Recurrent Lentigo Maligna and Lentigo Maligna Melanoma: Characteristics and Time to Recurrence After Surgery. ( 28296789 )
2017
5
Lentigo maligna melanoma with a history of cosmetic treatment: Prevalence, surgical outcomes and considerations. ( 28555933 )
2017
6
Hyperspectral imaging in detecting dermal invasion in lentigo maligna melanoma. ( 28012166 )
2016
7
Lifetime UV exposure and Lentigo Maligna Melanoma. ( 27925150 )
2016
8
Extrafacial lentigo maligna melanoma is reported often in Australia, more so at lower latitudes. ( 26820786 )
2016
9
Staged Excision for Lentigo Maligna and Lentigo Maligna Melanoma: Analysis of Surgical Margins and Long-term Recurrence in 68 Cases from a Single Practice. ( 27386048 )
2016
10
Epidemiology of Lentigo Maligna andA Lentigo Maligna Melanoma in theA Netherlands, 1989-2013. ( 27349862 )
2016
11
A systematic review on the role of imiquimod in lentigo maligna and lentigo maligna melanoma: need for standardization of treatment schedule and outcome measures. ( 27987308 )
2016
12
Comparison of MITF and Melan-A Immunohistochemistry During Mohs Surgery for Lentigo Maligna-Type Melanoma In Situ and Lentigo Maligna Melanoma. ( 26771682 )
2016
13
Lentigo Maligna Melanoma With Local and Distant Blue Nevus-like Metastases. ( 25943243 )
2015
14
Reviewing Challenges in the Diagnosis and Treatment of Lentigo Maligna and Lentigo-Maligna Melanoma. ( 27182482 )
2015
15
Intraoperative real-time reflectance confocal microscopy for guiding surgical margins of lentigo maligna melanoma. ( 26050216 )
2015
16
Curative Electrochemotherapy in Lentigo Maligna Melanoma. ( 26861530 )
2015
17
Clinical usefulness of reflectance confocal microscopy in the management of facial lentigo maligna melanoma. ( 24657027 )
2014
18
Lentigo maligna and lentigo maligna melanoma as occupational skin diseases in a forestry worker with long-standing occupational UV-exposure. ( 24903264 )
2014
19
Johnson square procedure for lentigo maligna and lentigo maligna melanoma. ( 24934910 )
2014
20
Delineating Margins of Lentigo Maligna (Melanoma) Using a Hyperspectral Imaging System. ( 25394551 )
2014
21
Clinicopathological characteristics of 270 patients with lentigo maligna and lentigo maligna melanoma: data from a German skin cancer centre. ( 24958545 )
2014
22
Mohs micrographic surgery for lentigo maligna and lentigo maligna melanoma using Mel-5 immunostaining: an update from the University of Minnesota. ( 24164856 )
2013
23
Recurrent lentigo maligna melanoma commingling the tumour nests of a basal cell carcinoma. ( 23623186 )
2013
24
Clinical Usefulness of Reflectance Confocal Microscopy in the Management of Facial Lentigo Maligna Melanoma. ( 23642470 )
2013
25
Distribution of MC1R variants among melanoma subtypes: p.R163Q is associated with lentigo maligna melanoma in a Mediterranean population. ( 23647022 )
2013
26
KIT and BRAF mutational status in a patient with a synchronous lentigo maligna melanoma and a gastrointestinal stromal tumor. ( 22175303 )
2012
27
Surgical and histologic pitfalls in the management of lentigo maligna melanoma. ( 22370566 )
2012
28
Dermoscopy of lentigo maligna melanoma: report of 125 cases. ( 22404578 )
2012
29
Geometric staged excision for the treatment of lentigo maligna and lentigo maligna melanoma: a long-term experience with literature review. ( 22782151 )
2012
30
The perimeter technique in the surgical treatment of lentigo maligna and lentigo maligna melanoma. ( 22683018 )
2012
31
Risk factors for lentigo maligna melanoma compared with superficial spreading melanoma: a case-control study in Australia. ( 22004881 )
2012
32
Grenz ray treatment of lentigo maligna and early lentigo maligna melanoma. ( 22030019 )
2012
33
Treatment of extensive lentigo maligna melanoma of the scalp by brachytherapy moulage technique. ( 20874783 )
2011
34
Lentigo maligna: melanoma in situ on chronically sun-damaged skin. ( 21732771 )
2011
35
Lentigo maligna melanoma--the review. ( 21305747 )
2010
36
Underlying amelanotic lentigo maligna melanoma uncovered after a severe blistering sunburn. ( 20919599 )
2010
37
Staged excision of lentigo maligna and lentigo maligna melanoma: a 10-year experience. ( 19952650 )
2009
38
Lentigo maligna melanoma with folliculotropism: dermoscopic features during rapid progression. ( 19528438 )
2009
39
Atypical fibroxanthoma, lentigo maligna melanoma and squamous cell carcinoma arising in the site of a thermal burn treated with skin grafts. ( 18963287 )
2009
40
Reflectance confocal microscopy of facial lentigo maligna and lentigo maligna melanoma: a preliminary study. ( 19566662 )
2009
41
Matrix metalloproteinases 2 and 9 in lentigo maligna melanoma. ( 19528914 )
2009
42
Collision tumor composed of Merkel cell carcinoma and lentigo maligna melanoma. ( 18190446 )
2008
43
Staged excision for lentigo maligna and lentigo maligna melanoma: A retrospective analysis of 117 cases. ( 18029055 )
2008
44
Identification of progenitor cancer stem cell in lentigo maligna melanoma. ( 18727808 )
2008
45
Acral lentiginous melanoma versus lentigo maligna melanoma among Iraqi patients. ( 17206300 )
2007
46
Lentigo maligna (melanoma in situ) treated with imiquimod cream 5%: 12 case reports. ( 17388218 )
2007
47
Staged excision versus Mohs micrographic surgery for lentigo maligna and lentigo maligna melanoma. ( 17870430 )
2007
48
Progression of lentigo maligna into lentigo maligna melanoma following laser treatment. ( 17478397 )
2007
49
Lentigo maligna/lentigo maligna melanoma: current state of diagnosis and treatment. ( 16681656 )
2006
50
Conventional histology vs. three-dimensional histology in lentigo maligna melanoma. ( 16445775 )
2006

Variations for Lentigo Maligna Melanoma

Expression for Lentigo Maligna Melanoma

Search GEO for disease gene expression data for Lentigo Maligna Melanoma.

Pathways for Lentigo Maligna Melanoma

GO Terms for Lentigo Maligna Melanoma

Biological processes related to Lentigo Maligna Melanoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 ephrin receptor signaling pathway GO:0048013 9.37 MMP2 MMP9
2 extracellular matrix disassembly GO:0022617 9.32 MMP2 MMP9
3 collagen catabolic process GO:0030574 9.26 MMP2 MMP9
4 embryo implantation GO:0007566 9.16 MMP2 MMP9
5 endodermal cell differentiation GO:0035987 8.96 MMP2 MMP9
6 positive regulation of vascular smooth muscle cell proliferation GO:1904707 8.62 MMP2 MMP9

Sources for Lentigo Maligna Melanoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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