MCID: LNT002
MIFTS: 36

Lentigo Maligna Melanoma

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Lentigo Maligna Melanoma

MalaCards integrated aliases for Lentigo Maligna Melanoma:

Name: Lentigo Maligna Melanoma 49 69
Hutchison Melanotic Freckle 49
Lmm 49

Classifications:



External Ids:

UMLS 69 C2739810

Summaries for Lentigo Maligna Melanoma

NIH Rare Diseases : 49 Lentigo maligna melanoma (LMM) is a type of skin cancer that usually develops in older, fair-skinned adults.  The average age of diagnosis is 65.  LMM is thought to be caused by a history of sun exposure to the affected area.  Treatment includes surgery to remove as much of the LMM as possible. Last updated: 11/23/2012

MalaCards based summary : Lentigo Maligna Melanoma, also known as hutchison melanotic freckle, is related to melanoma and lentigines. An important gene associated with Lentigo Maligna Melanoma is MC1R (Melanocortin 1 Receptor), and among its related pathways/superpathways are Pathways in cancer and Matrix Metalloproteinases. The drugs Imiquimod and interferons have been mentioned in the context of this disorder. Affiliated tissues include skin, and related phenotypes are integument and pigmentation

Wikipedia : 72 Lentigo maligna melanoma is a melanoma that has evolved from a lentigo maligna. They are usually found... more...

Related Diseases for Lentigo Maligna Melanoma

Diseases related to Lentigo Maligna Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 82)
# Related Disease Score Top Affiliating Genes
1 melanoma 30.9 MC1R MITF MLANA S100B
2 lentigines 30.0 MC1R MITF MLANA
3 basal cell carcinoma 10.3
4 superficial spreading melanoma 10.3
5 basal cell carcinoma 1 10.3
6 nodular malignant melanoma 10.2
7 gallbladder melanoma 10.2 MITF MLANA
8 pigmented basal cell carcinoma 10.2 MITF MLANA
9 epithelioid cell melanoma 10.2 MITF MLANA
10 breast angiosarcoma 10.2 MITF MLANA
11 actinic keratosis 10.2 MC1R MMP2
12 melanoma, cutaneous malignant 1 10.1 MC1R MITF
13 merkel cell carcinoma 10.1
14 acral lentiginous melanoma 10.1
15 keratosis, seborrheic 10.1
16 xeroderma pigmentosum, variant type 10.1
17 aging 10.1
18 gastrointestinal stromal tumor 10.1
19 burns 10.1
20 skin disease 10.1
21 dermatomyositis 10.1
22 keratosis 10.1
23 squamous cell carcinoma 10.1
24 neurofibroma 10.1 MITF S100B
25 clear cell sarcoma 10.1 MITF S100B
26 meningeal melanocytoma 10.0 MLANA S100B
27 extracranial arteriovenous malformation 9.9 MMP2 MMP9
28 focal myositis 9.9 MMP2 MMP9
29 spastic entropion 9.9 MMP2 MMP9
30 villous adenocarcinoma 9.9 MMP2 MMP9
31 psammomatous meningioma 9.9 MMP2 MMP9
32 acute transverse myelitis 9.9 MMP2 MMP9
33 senile ectropion 9.9 MMP2 MMP9
34 internal hemorrhoid 9.9 MMP2 MMP9
35 parotitis 9.9 MMP2 MMP9
36 light chain deposition disease 9.9 MMP2 MMP9
37 microcystic meningioma 9.9 MMP2 MMP9
38 klatskin's tumor 9.9 MMP2 MMP9
39 integumentary system cancer 9.9 MC1R MITF MLANA
40 adenomyosis 9.9 MMP2 MMP9
41 hypercementosis 9.9 MMP2 MMP9
42 corneal ulcer 9.9 MMP2 MMP9
43 sorsby fundus dystrophy 9.9 MMP2 MMP9
44 transverse myelitis 9.9 MMP2 MMP9
45 lung giant cell carcinoma 9.9 MMP2 MMP9
46 pelvic organ prolapse 9.9 MMP2 MMP9
47 hypertensive heart disease 9.9 MMP2 MMP9
48 aortic aneurysm, familial thoracic 1 9.9 MMP2 MMP9
49 inguinal hernia 9.9 MMP2 MMP9
50 pneumothorax 9.9 MMP2 MMP9

Graphical network of the top 20 diseases related to Lentigo Maligna Melanoma:



Diseases related to Lentigo Maligna Melanoma

Symptoms & Phenotypes for Lentigo Maligna Melanoma

MGI Mouse Phenotypes related to Lentigo Maligna Melanoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.35 MC1R MITF MLANA MMP9 S100B
2 pigmentation MP:0001186 8.8 MC1R MITF MLANA

Drugs & Therapeutics for Lentigo Maligna Melanoma

Drugs for Lentigo Maligna Melanoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Imiquimod Approved, Investigational Phase 3,Phase 2 99011-02-6 57469
2 interferons Phase 3,Phase 2
3 Adjuvants, Immunologic Phase 3,Phase 2
4 Interferon Inducers Phase 3,Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Relevance of Imiquimod as Neo-adjuvant Treatment to Reduce Excision Size and the Risk of Intralesional Excision in Lentigo Malignant of the Face Recruiting NCT01720407 Phase 3 Imiquimod cream + surgery;Placebo + surgery
2 Imiquimod to Detect Residual Lesions and Prevent Recurrence of Lentigo Maligna Active, not recruiting NCT01088737 Phase 2, Phase 3 Imiquimod
3 Dinaciclib in Treating Patients With Stage IV Melanoma Active, not recruiting NCT00937937 Phase 2 Dinaciclib

Search NIH Clinical Center for Lentigo Maligna Melanoma

Genetic Tests for Lentigo Maligna Melanoma

Anatomical Context for Lentigo Maligna Melanoma

MalaCards organs/tissues related to Lentigo Maligna Melanoma:

38
Skin

Publications for Lentigo Maligna Melanoma

Articles related to Lentigo Maligna Melanoma:

(show top 50) (show all 135)
# Title Authors Year
1
Immunocryosurgery as monotherapy for lentigo maligna or combined with surgical excision for lentigo maligna melanoma. ( 29430695 )
2018
2
Amelanotic Lentigo Maligna Melanoma: Mohs Surgery as the Definitive Treatment of an Invisible Tumour. ( 28685596 )
2017
3
Locally Recurrent Lentigo Maligna and Lentigo Maligna Melanoma: Characteristics and Time to Recurrence After Surgery. ( 28296789 )
2017
4
Correlation of Handheld Reflectance Confocal Microscopy With Radial Video Mosaicing for Margin Mapping of Lentigo Maligna and Lentigo Maligna Melanoma. ( 29049429 )
2017
5
Lentigo maligna melanoma with a history of cosmetic treatment: Prevalence, surgical outcomes and considerations. ( 28555933 )
2017
6
Synchronous conjunctival melanoma and lentigo maligna melanoma. ( 28954115 )
2017
7
TIMPs expression in lentigo malignaA^lentigo maligna melanoma versus aged skin - a review of the literature and personal experience. ( 29250646 )
2017
8
Very Rare Amelanotic Lentigo Maligna Melanoma with Skull Roof Invasion. ( 28785332 )
2017
9
Hyperspectral imaging in detecting dermal invasion in lentigo maligna melanoma. ( 28012166 )
2016
10
A systematic review on the role of imiquimod in lentigo maligna and lentigo maligna melanoma: need for standardization of treatment schedule and outcome measures. ( 27987308 )
2016
11
Comparison of MITF and Melan-A Immunohistochemistry During Mohs Surgery for Lentigo Maligna-Type Melanoma In Situ and Lentigo Maligna Melanoma. ( 26771682 )
2016
12
Epidemiology of Lentigo Maligna andA Lentigo Maligna Melanoma in theA Netherlands, 1989-2013. ( 27349862 )
2016
13
Lifetime UV exposure and Lentigo Maligna Melanoma. ( 27925150 )
2016
14
Extrafacial lentigo maligna melanoma is reported often in Australia, more so at lower latitudes. ( 26820786 )
2016
15
Staged Excision for Lentigo Maligna and Lentigo Maligna Melanoma: Analysis of Surgical Margins and Long-term Recurrence in 68 Cases from a Single Practice. ( 27386048 )
2016
16
Reviewing Challenges in the Diagnosis and Treatment of Lentigo Maligna and Lentigo-Maligna Melanoma. ( 27182482 )
2015
17
Lentigo Maligna Melanoma With Local and Distant Blue Nevus-like Metastases. ( 25943243 )
2015
18
Curative Electrochemotherapy in Lentigo Maligna Melanoma. ( 26861530 )
2015
19
Intraoperative real-time reflectance confocal microscopy for guiding surgical margins of lentigo maligna melanoma. ( 26050216 )
2015
20
Delineating Margins of Lentigo Maligna (Melanoma) Using a Hyperspectral Imaging System. ( 25394551 )
2014
21
Clinicopathological characteristics of 270 patients with lentigo maligna and lentigo maligna melanoma: data from a German skin cancer centre. ( 24958545 )
2014
22
Lentigo maligna and lentigo maligna melanoma as occupational skin diseases in a forestry worker with long-standing occupational UV-exposure. ( 24903264 )
2014
23
Clinical usefulness of reflectance confocal microscopy in the management of facial lentigo maligna melanoma. ( 24657027 )
2014
24
Johnson square procedure for lentigo maligna and lentigo maligna melanoma. ( 24934910 )
2014
25
Recurrent lentigo maligna melanoma commingling the tumour nests of a basal cell carcinoma. ( 23623186 )
2013
26
Distribution of MC1R variants among melanoma subtypes: p.R163Q is associated with lentigo maligna melanoma in a Mediterranean population. ( 23647022 )
2013
27
Clinical Usefulness of Reflectance Confocal Microscopy in the Management of Facial Lentigo Maligna Melanoma. ( 23642470 )
2013
28
Mohs micrographic surgery for lentigo maligna and lentigo maligna melanoma using Mel-5 immunostaining: an update from the University of Minnesota. ( 24164856 )
2013
29
Geometric staged excision for the treatment of lentigo maligna and lentigo maligna melanoma: a long-term experience with literature review. ( 22782151 )
2012
30
The perimeter technique in the surgical treatment of lentigo maligna and lentigo maligna melanoma. ( 22683018 )
2012
31
Risk factors for lentigo maligna melanoma compared with superficial spreading melanoma: a case-control study in Australia. ( 22004881 )
2012
32
Dermoscopy of lentigo maligna melanoma: report of 125 cases. ( 22404578 )
2012
33
Grenz ray treatment of lentigo maligna and early lentigo maligna melanoma. ( 22030019 )
2012
34
KIT and BRAF mutational status in a patient with a synchronous lentigo maligna melanoma and a gastrointestinal stromal tumor. ( 22175303 )
2012
35
Surgical and histologic pitfalls in the management of lentigo maligna melanoma. ( 22370566 )
2012
36
Lentigo maligna: melanoma in situ on chronically sun-damaged skin. ( 21732771 )
2011
37
Treatment of extensive lentigo maligna melanoma of the scalp by brachytherapy moulage technique. ( 20874783 )
2011
38
Underlying amelanotic lentigo maligna melanoma uncovered after a severe blistering sunburn. ( 20919599 )
2010
39
Lentigo maligna melanoma--the review. ( 21305747 )
2010
40
Matrix metalloproteinases 2 and 9 in lentigo maligna melanoma. ( 19528914 )
2009
41
Reflectance confocal microscopy of facial lentigo maligna and lentigo maligna melanoma: a preliminary study. ( 19566662 )
2009
42
Staged excision of lentigo maligna and lentigo maligna melanoma: a 10-year experience. ( 19952650 )
2009
43
Lentigo maligna melanoma with folliculotropism: dermoscopic features during rapid progression. ( 19528438 )
2009
44
Atypical fibroxanthoma, lentigo maligna melanoma and squamous cell carcinoma arising in the site of a thermal burn treated with skin grafts. ( 18963287 )
2009
45
Staged excision for lentigo maligna and lentigo maligna melanoma: A retrospective analysis of 117 cases. ( 18029055 )
2008
46
Identification of progenitor cancer stem cell in lentigo maligna melanoma. ( 18727808 )
2008
47
Collision tumor composed of Merkel cell carcinoma and lentigo maligna melanoma. ( 18190446 )
2008
48
Acral lentiginous melanoma versus lentigo maligna melanoma among Iraqi patients. ( 17206300 )
2007
49
Staged excision versus Mohs micrographic surgery for lentigo maligna and lentigo maligna melanoma. ( 17870430 )
2007
50
Progression of lentigo maligna into lentigo maligna melanoma following laser treatment. ( 17478397 )
2007

Variations for Lentigo Maligna Melanoma

Expression for Lentigo Maligna Melanoma

Search GEO for disease gene expression data for Lentigo Maligna Melanoma.

Pathways for Lentigo Maligna Melanoma

GO Terms for Lentigo Maligna Melanoma

Biological processes related to Lentigo Maligna Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ephrin receptor signaling pathway GO:0048013 9.4 MMP2 MMP9
2 extracellular matrix disassembly GO:0022617 9.37 MMP2 MMP9
3 collagen catabolic process GO:0030574 9.32 MMP2 MMP9
4 embryo implantation GO:0007566 9.26 MMP2 MMP9
5 pigmentation GO:0043473 9.16 MC1R MITF
6 endodermal cell differentiation GO:0035987 8.96 MMP2 MMP9
7 positive regulation of vascular smooth muscle cell proliferation GO:1904707 8.62 MMP2 MMP9

Sources for Lentigo Maligna Melanoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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