LMM
MCID: LNT002
MIFTS: 39

Lentigo Maligna Melanoma (LMM) malady

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Summaries for Lentigo Maligna Melanoma

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43NIH Rare Diseases, 65Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Lentigo maligna melanoma (lmm) is a type of skin cancer that usually develops in older, fair-skinned adults.  the average age of diagnosis is 65.  lmm is thought to be caused by a history of sun exposure to the affected area.  treatment includes surgery to remove as much of the lmm as possible. last updated: 11/23/2012

MalaCards: Lentigo Maligna Melanoma, also known as hutchinson's melanotic freckle, is related to melanoma and basal cell carcinoma. An important gene associated with Lentigo Maligna Melanoma is NKX2-1 (NK2 homeobox 1), and among its related pathways are Angiogenesis and AGE/RAGE pathway. The compounds mucicarmine and b 723 have been mentioned in the context of this disorder. Affiliated tissues include skin, and related mouse phenotypes are integument and skeleton.

Wikipedia:65 Lentigo maligna melanoma is a melanoma that has evolved from a lentigo maligna. They are usually found... more...

Aliases & Classifications for Lentigo Maligna Melanoma

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43NIH Rare Diseases, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

lentigo maligna melanoma 43 62
hutchinson's melanotic freckle 62
hutchison melanotic freckle 43
lmm 43


Related Diseases for Lentigo Maligna Melanoma

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17GeneCards, 18GeneDecks
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Diseases related to Lentigo Maligna Melanoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 56)
idRelated DiseaseScoreTop Affiliating Genes
1melanoma31.8MLANA, MMP9, MITF, NKX2-1, MMP2, S100B
2basal cell carcinoma10.6
3superficial spreading melanoma10.6
4burns10.4
5gastrointestinal stromal tumor10.4
6acral lentiginous melanoma10.4
7xeroderma pigmentosum10.4
8merkel cell carcinoma10.4
9dermatomyositis10.4
10keratosis10.4
11seborrheic keratosis10.4
12cutaneous malignant melanoma10.4
13meningioma10.1S100B
14juvenile xanthogranuloma10.1MLANA, S100B
15granular cell tumor10.1MLANA, S100B
16sex cord-gonadal stromal tumor10.0NKX2-1, S100B
17perivascular epithelioid cell tumor10.0MITF, MLANA
18leiomyosarcoma10.0MLANA, S100B
19neuroendocrine carcinoma10.0S100B, NKX2-1
20angiomyolipoma10.0MITF, MLANA
21vitiligo10.0MLANA, MITF
22clear cell sarcoma10.0S100B, MITF
23fibrous histiocytoma10.0S100B, MITF
24malignant peripheral nerve sheath tumor10.0MITF, S100B
25neurofibroma10.0MITF, S100B
26stroke, ischemic10.0S100B, MMP9
27lymphangioleiomyomatosis10.0MLANA, MMP2
28neurilemmoma10.0MITF, S100B
29tongue cancer10.0MMP9, MMP2
30conjunctivochalasis10.0MMP2, MMP9
31abdominal aortic aneurysm10.0MMP2, MMP9
32keratitis10.0MMP2, MMP9
33bladder carcinoma in situ10.0MMP9, MMP2
34aneurysm10.0MMP9, MMP2
35anaplastic astrocytoma10.0MMP9, MMP2
36microphthalmia10.0S100B, MLANA, MITF
37periodontal disease10.0MMP9, MMP2
38giant cell tumor10.0MMP9, MITF, S100B
39oral cancer10.0MMP2, MMP9
40pulmonary fibrosis10.0MMP9, MMP2
41fibrosarcoma10.0MLANA, MMP2, MMP9
42congenital heart disease10.0MMP9, MMP2
43lung adenocarcinoma10.0MMP9, MMP2, NKX2-1
44endometrial carcinoma10.0MMP9, MMP2, NKX2-1
45colorectal cancer10.0MMP9, MMP2, NKX2-1
46non-small cell lung carcinoma10.0MMP9, NKX2-1, MMP2
47astrocytoma10.0S100B, MMP9, MMP2
48glioblastoma multiforme9.9S100B, MMP2, MMP9
49breast cancer9.9MMP9, NKX2-1, MMP2
50ovarian cancer9.9MMP9, MLANA, MMP2

Graphical network of the top 20 diseases related to Lentigo Maligna Melanoma:



Diseases related to lentigo maligna melanoma

Symptoms for Lentigo Maligna Melanoma

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Drugs & Therapeutics for Lentigo Maligna Melanoma

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Lentigo Maligna Melanoma

Search NIH Clinical Center for Lentigo Maligna Melanoma

Genetic Tests for Lentigo Maligna Melanoma

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Anatomical Context for Lentigo Maligna Melanoma

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33MalaCards
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MalaCards organs/tissues related to Lentigo Maligna Melanoma:

33
Skin

Animal Models for Lentigo Maligna Melanoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Lentigo Maligna Melanoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.2S100B, MITF, MMP9, MLANA
2MP:00053907.8NKX2-1, MITF, MMP2, MMP9

Publications for Lentigo Maligna Melanoma

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52PubMed
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Articles related to Lentigo Maligna Melanoma:

(show top 50)    (show all 111)
idTitleAuthorsYear
1
Distribution of MC1R variants among melanoma subtypes: p.R163Q is associated with lentigo maligna melanoma in a Mediterranean population. (23647022)
2013
2
KIT and BRAF mutational status in a patient with a synchronous lentigo maligna melanoma and a gastrointestinal stromal tumor. (22175303)
2012
3
Lentigo maligna melanoma--the review. (21305747)
2010
4
Matrix metalloproteinases 2 and 9 in lentigo maligna melanoma. (19528914)
2009
5
Staged excision for lentigo maligna and lentigo maligna melanoma: A retrospective analysis of 117 cases. (18029055)
2008
6
Staged excision versus Mohs micrographic surgery for lentigo maligna and lentigo maligna melanoma. (17870430)
2007
7
Progression of lentigo maligna into lentigo maligna melanoma following laser treatment. (17478397)
2007
8
Hypomyopathic dermatomyositis associated with lentigo maligna melanoma. (16781317)
2006
9
A collision tumor involving Basal cell carcinoma and lentigo maligna melanoma. (16121053)
2005
10
Management of lentigo maligna and lentigo maligna melanoma with staged excision: a 5-year follow-up. (15148099)
2004
11
Lentigo maligna melanoma. (15624713)
2004
12
A comparison of dermoscopic features among lentigo senilis/initial seborrheic keratosis, seborrheic keratosis, lentigo maligna and lentigo maligna melanoma on the face. (15729860)
2004
13
Surgical margins for lentigo maligna and lentigo maligna melanoma: the technique of mapped serial excision. (15381549)
2004
14
Amelanotic lentigo maligna melanoma. (14724412)
2004
15
Management of early lentigo maligna and lentigo maligna melanoma of the head and neck. (15062292)
2003
16
Parasitism of basal cell carcinoma by lentigo maligna melanoma. (12734489)
2003
17
Topical treatment of lentigo maligna melanoma with imiquimod 5% cream. (14571081)
2003
18
Recurrent lentigo maligna melanoma: regression associated with local azelaic acid 20%. (11831841)
2002
19
Ultraviolet-assisted punch biopsy mapping for lentigo maligna melanoma. (11352422)
2001
20
Fractionated radiotherapy of lentigo maligna and lentigo maligna melanoma in 64 patients. (10954659)
2000
21
Lentigo maligna melanoma. (10865932)
2000
22
Amelanotic lentigo maligna melanoma: a unique case presentation. (10469082)
1999
23
Amelanotic lentigo maligna melanoma: report of a case and review of the literature. (10431675)
1999
24
Lentigo maligna melanoma and excisional biopsy techniques. (10088870)
1999
25
Mohs micrographic surgery for lentigo maligna and lentigo maligna melanoma. A follow-up study. (9648576)
1998
26
Extrafacial lentigo maligna melanoma: analysis of 71 cases and comparison with lentigo maligna melanoma of the head and neck. (9767288)
1998
27
Lentigo maligna and lentigo maligna melanoma. (9091498)
1997
28
Lentigo maligna and lentigo maligna melanoma. (9204053)
1997
29
Comparison between lentigo maligna melanoma and other histogenetic types of malignant melanoma of the head and neck. Scottish Melanoma Group. (8611411)
1996
30
Cytodiagnosis of pulmonary metastatic malignant melanoma from lentigo maligna melanoma. (7669930)
1995
31
Amelanotic lentigo maligna melanoma. (7829736)
1995
32
Management of lentigo maligna and lentigo maligna melanoma with tangential paraffin-embedded sections. (8089308)
1994
33
Successful treatment of lentigo maligna and lentigo maligna melanoma with Mohs' micrographic surgery aided by rush permanent sections. (8199993)
1994
34
Angiocentric invasion by lentigo maligna melanoma. (8132839)
1994
35
Management of lentigo maligna and lentigo maligna melanoma with paraffin-embedded tangential sections: utility of immunoperoxidase staining and supplemental vertical sections. (8408795)
1993
36
Metastatic lentigo maligna melanoma. (2299024)
1990
37
The risk of progression of lentigo maligna to lentigo maligna melanoma. (3567069)
1987
38
Microinvasive lentigo maligna melanoma. (3312317)
1987
39
Lentigo maligna melanoma with deep invasion along the mental nerve. (3459796)
1986
40
Lentigo maligna melanoma has no better prognosis than other types of melanoma. (6470757)
1984
41
Lentigo maligna melanoma yields to radiotherapy. (6848821)
1983
42
Conventional fractionated radiotherapy for 51 patients with lentigo maligna and lentigo maligna melanoma. (6863069)
1983
43
Amelanotic lentigo maligna melanoma manifesting as a dermatitislike plaque. (6847222)
1983
44
Treatment of lentigo maligna and lentigo maligna melanoma. (7391322)
1980
45
The radiotherapy of lentigo maligna and lentigo maligna melanoma of the head and neck. (7379026)
1980
46
Tumor conference 21. Lentigo maligna melanoma. (762304)
1979
47
Pagetoid malignant melanoma and lentigo maligna melanoma of toe. A study with the fluorescence method (Falck and Hillarp). (718255)
1978
48
Proceedings: Lentigo-maligna melanoma: an ultrastructural study. (1276041)
1976
49
Tyrosinase activity in three types of the malignant melanoma: superficial spreading melanoma, lentigo maligna melanoma and nodular melanoma. (50762)
1975
50
Lentigo maligna and lentigo-maligna melanoma. (5776171)
1969

Variations for Lentigo Maligna Melanoma

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Expression for genes affiliated with Lentigo Maligna Melanoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lentigo Maligna Melanoma

Search GEO for disease gene expression data for Lentigo Maligna Melanoma.

Pathways for genes affiliated with Lentigo Maligna Melanoma

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50PathCards, 5Cell Signaling Technology, 38NCBI BioSystems Database, 60Thomson Reuters, 12EMD Millipore, 30KEGG, 53QIAGEN, 55Reactome, 54R&D Systems
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Compounds for genes affiliated with Lentigo Maligna Melanoma

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45Novoseek, 11DrugBank, 61Tocris Bioscience, 29IUPHAR, 3BitterDB, 24HMDB, 51PharmGKB
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Compounds related to Lentigo Maligna Melanoma according to GeneCards/GeneDecks:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1mucicarmine4510.0NKX2-1, S100B
2b 723459.9S100B, NKX2-1
3flavanol459.5MMP9, MMP2
4cgs-27023a459.5MMP9, MMP2
5methyl selenol459.5MMP9, MMP2
6col 3459.5MMP9, MMP2
7prinomastat459.5MMP9, MMP2
8trapidil459.5MMP2, MMP9
9ilomastat459.5MMP2, MMP9
10lercanidipine45 1110.5MMP2, MMP9
11tranilast459.5MMP9, MMP2
12gelfoam459.4MMP2, MMP9
13latanoprost45 1110.4MMP2, MMP9
14cilomilast459.4MMP2, MMP9
15(4-aminophenyl)mercuric acetate459.4MMP2, MMP9
16uk 383367619.4MMP9, MMP2
17gi 254023x619.4MMP9, MMP2
18gm 6001619.4MMP9, MMP2
19hydroxamate459.4MMP2, MMP9
20marimastat45 61 1111.4MMP2, MMP9
21zoledronic acid459.4MMP2, MMP9
22ciglitazone45 2910.3MMP2, MMP9
238-isoprostane459.3MMP2, MMP9
241,10-phenanthroline45 310.3MMP9, MMP2
25ns 39845 6110.3MMP2, MMP9
26batimastat45 61 1111.3MMP9, MMP2
27silymarin459.2MMP2, MMP9
28formaldehyde45 2410.2MMP9, NKX2-1, S100B
29hydroxyproline45 24 1111.1MMP2, MMP9
30cyclic amp45 2410.1S100B, NKX2-1, MITF
31ivig459.0MMP9, MMP2
323-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide459.0S100B, MMP2, MMP9
33ribonucleic acid459.0NKX2-1, MMP2, MMP9
34erythromycin45 3 51 1111.9MMP9, MMP2
35norepinephrine45 24 1110.9MMP9, MMP2, S100B
36wortmannin458.9MMP9, MMP2, S100B
3712-o-tetradecanoylphorbol 13-acetate458.9MMP9, MMP2, MITF
38proline458.8S100B, MMP2, MMP9
39creatinine458.8S100B, MMP2, MMP9
40ribavirin45 51 1110.7MMP2, MMP9
41aspartate458.7MMP9, MMP2, S100B
42hematoxylin458.7MLANA, MMP9, NKX2-1, S100B
43zinc45 249.6MMP9, MMP2, NKX2-1, S100B
44estrogen458.5S100B, NKX2-1, MMP2, MMP9
45retinoic acid45 249.5MMP9, MMP2, NKX2-1, S100B
46lactate458.5S100B, MMP2, MMP9, MLANA
47glutamate458.4S100B, MITF, MMP2, MMP9
48serine458.3S100B, NKX2-1, MMP2, MMP9
49tyrosine458.1S100B, NKX2-1, MITF, MMP2, MMP9
50paraffin457.6S100B, NKX2-1, MITF, MMP2, MMP9, MLANA

GO Terms for genes affiliated with Lentigo Maligna Melanoma

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16Gene Ontology
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Biological processes related to Lentigo Maligna Melanoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix disassemblyGO:0226179.0MMP2, MMP9
2embryo implantationGO:0075668.9MMP2, MMP9
3collagen catabolic processGO:0305748.7MMP2, MMP9

Molecular functions related to Lentigo Maligna Melanoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityGO:0037059.2NKX2-1, MITF
2metalloendopeptidase activityGO:0042229.0MMP2, MMP9
3protein bindingGO:0055157.0S100B, MLANA, MMP9, MMP2, MITF, NKX2-1

Products for genes affiliated with Lentigo Maligna Melanoma

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Sources for Lentigo Maligna Melanoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet