LMM
MCID: LNT002
MIFTS: 28

Lentigo Maligna Melanoma (LMM) malady

Summaries for Lentigo Maligna Melanoma

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Lentigo maligna melanoma (lmm) is a type of skin cancer that usually develops in older, fair-skinned adults.  the average age of diagnosis is 65.  lmm is thought to be caused by a history of sun exposure to the affected area.  treatment includes surgery to remove as much of the lmm as possible. last updated: 11/23/2012

MalaCards: Lentigo Maligna Melanoma, also known as hutchinson's melanotic freckle, is related to melanoma and amelanotic melanoma. An important gene associated with Lentigo Maligna Melanoma is NKX2-1 (NK2 homeobox 1), and among its related pathways are AGE/RAGE pathway and Matrix Metalloproteinases. The compounds mucicarmine and b 723 have been mentioned in the context of this disorder. Affiliated tissues include skin, and related mouse phenotypes are integument and skeleton.

Wikipedia:63 Lentigo maligna melanoma is a melanoma that has evolved from a lentigo maligna. They are usually found... more...

Aliases & Classifications for Lentigo Maligna Melanoma

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42NIH Rare Diseases, 60UMLS
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Aliases & Descriptions:

lentigo maligna melanoma 42 60
hutchinson's melanotic freckle 60
hutchison melanotic freckle 42
lmm 42


Related Diseases for Lentigo Maligna Melanoma

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17GeneCards, 18GeneDecks
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Diseases related to Lentigo Maligna Melanoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 64)
idRelated DiseaseScoreTop Affiliating Genes
1melanoma31.9MMP2, MITF, MMP9, NKX2-1, MLANA, S100B
2amelanotic melanoma10.8
3basal cell carcinoma10.5
4skin melanoma10.5
5nodular malignant melanoma10.5
6burns10.3
7xeroderma pigmentosum10.3
8gastrointestinal stromal tumor10.3
9acral lentiginous melanoma10.3
10merkel cell carcinoma10.3
11dermatomyositis10.3
12keratosis10.3
13seborrheic keratosis10.3
14skin squamous cell carcinoma10.3
15squamous cell carcinoma10.3
16testicular cancer10.0MLANA
17adenoma10.0NKX2-1
18paraganglioma10.0S100B
19thymoma10.0NKX2-1
20leiomyoma10.0S100B
21malignant mesothelioma10.0NKX2-1
22tuberous sclerosis10.0S100B
23laryngeal benign neoplasm10.0MMP2
24chondrosarcoma10.0S100B
25retinoblastoma10.0MITF
26dermatofibrosarcoma protuberans10.0S100B
27meningitis10.0MMP9
28smooth muscle tumor10.0S100B
29thyroid cancer10.0NKX2-1
30lymphangioleiomyomatosis10.0MLANA, MMP2
31granular cell tumor10.0MLANA, S100B
32sarcoma10.0S100B, MLANA
33juvenile xanthogranuloma10.0MLANA, S100B
34leiomyosarcoma10.0S100B, MLANA
35perivascular epithelioid cell tumor10.0MLANA, MITF
36angiomyolipoma10.0MLANA, MITF
37sex cord-gonadal stromal tumor10.0S100B, NKX2-1
38carotid stenosis10.0MMP9
39neurofibroma10.0MITF, S100B
40clear cell sarcoma10.0S100B, MITF
41neuroendocrine carcinoma10.0NKX2-1, S100B
42fibrous histiocytoma10.0S100B, MITF
43pulmonary emphysema10.0MMP9
44malignant peripheral nerve sheath tumor10.0MITF, S100B
45anaplastic astrocytoma10.0MMP9, MMP2
46tongue cancer10.0MMP9, MMP2
47conjunctivochalasis10.0MMP9, MMP2
48osteosarcoma10.0MMP2, MMP9
49abdominal aortic aneurysm10.0MMP9, MMP2
50aneurysm disease10.0MMP2, MMP9

Graphical network of the top 20 diseases related to Lentigo Maligna Melanoma:



Diseases related to lentigo maligna melanoma

Clinical Features for Lentigo Maligna Melanoma

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Drugs & Therapeutics for Lentigo Maligna Melanoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Lentigo Maligna Melanoma

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Anatomical Context for Lentigo Maligna Melanoma

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32MalaCards
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MalaCards organs/tissues related to Lentigo Maligna Melanoma:

32
Skin

Animal Models for Lentigo Maligna Melanoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Lentigo Maligna Melanoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.4MMP9, MITF, MLANA, S100B
2MP:00053907.8MMP9, MMP2, MITF, NKX2-1

Publications for Lentigo Maligna Melanoma

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Genetic Variations for Lentigo Maligna Melanoma

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Expression for genes affiliated with Lentigo Maligna Melanoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lentigo Maligna Melanoma

Search GEO for disease gene expression data for Lentigo Maligna Melanoma.

Pathways for genes affiliated with Lentigo Maligna Melanoma

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37NCBI BioSystems Database, 51QIAGEN, 52R&D Systems, 29KEGG
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Compounds for genes affiliated with Lentigo Maligna Melanoma

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44Novoseek, 11DrugBank, 59Tocris Bioscience, 24HMDB, 28IUPHAR, 2BitterDB, 49PharmGKB
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Compounds related to Lentigo Maligna Melanoma according to GeneCards/GeneDecks:

(show all 44)
idCompoundScoreTop Affiliating Genes
1mucicarmine4410.0NKX2-1, S100B
2b 723449.9NKX2-1, S100B
3flavanol449.5MMP2, MMP9
4cgs-27023a449.5MMP2, MMP9
5methyl selenol449.5MMP2, MMP9
6col 3449.5MMP2, MMP9
7prinomastat449.4MMP9, MMP2
8trapidil449.4MMP9, MMP2
9lercanidipine44 1110.4MMP2, MMP9
10ilomastat449.4MMP2, MMP9
11tranilast449.4MMP9, MMP2
12gelfoam449.4MMP9, MMP2
13latanoprost44 1110.4MMP2, MMP9
14cilomilast449.4MMP2, MMP9
15uk 383367599.4MMP2, MMP9
16gi 254023x599.4MMP2, MMP9
17gm 6001599.4MMP2, MMP9
18formaldehyde44 2410.4MMP9, NKX2-1, S100B
19hydroxamate449.4MMP2, MMP9
20marimastat44 59 1111.3MMP2, MMP9
21zoledronic acid449.3MMP9, MMP2
22ciglitazone44 2810.3MMP9, MMP2
238-isoprostane449.3MMP2, MMP9
241,10-phenanthroline44 210.2MMP9, MMP2
25ns 39844 5910.2MMP9, MMP2
26batimastat44 59 1111.2MMP2, MMP9
27silymarin449.1MMP9, MMP2
28ribavirin44 49 1111.0MMP2, MMP9
29creatinine449.0MMP9, MMP2
303-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.0MMP9, MMP2, S100B
31ribonucleic acid449.0MMP9, MMP2, NKX2-1
32hydroxyproline44 11 2410.9MMP2, MMP9
33hematoxylin448.9S100B, MLANA, NKX2-1, MMP9
3412-o-tetradecanoylphorbol 13-acetate448.8MITF, MMP2, MMP9
35norepinephrine44 11 2410.8S100B, MMP2, MMP9
36wortmannin448.8MMP9, MMP2, S100B
37erythromycin44 49 2 1111.7MMP9, MMP2
38proline448.6MMP9, MMP2, S100B
39zinc44 249.5S100B, NKX2-1, MMP2, MMP9
40estrogen448.5S100B, NKX2-1, MMP2, MMP9
41retinoic acid44 249.5MMP9, MMP2, NKX2-1, S100B
42lactate448.5S100B, MLANA, MMP2, MMP9
43tyrosine448.0S100B, NKX2-1, MITF, MMP2, MMP9
44paraffin447.6MMP9, MMP2, MITF, NKX2-1, MLANA, S100B

GO Terms for genes affiliated with Lentigo Maligna Melanoma

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16Gene Ontology
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Biological processes related to Lentigo Maligna Melanoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1collagen catabolic processGO:0305749.0MMP9, MMP2
2embryo implantationGO:0075668.7MMP9, MMP2

Molecular functions related to Lentigo Maligna Melanoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.1MMP9, MMP2, MITF, NKX2-1, MLANA, S100B

Products for genes affiliated with Lentigo Maligna Melanoma

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  • Antibodies
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Sources for Lentigo Maligna Melanoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet