MCID: LNT002
MIFTS: 28

Lentigo Maligna Melanoma malady

Rare diseases, Skin diseases categories

Aliases & Classifications for Lentigo Maligna Melanoma

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Aliases & Descriptions for Lentigo Maligna Melanoma:

Name: Lentigo Maligna Melanoma 45 65
Hutchison Melanotic Freckle 45
 
Lmm 45


Classifications:



Summaries for Lentigo Maligna Melanoma

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NIH Rare Diseases:45 Lentigo maligna melanoma (lmm) is a type of skin cancer that usually develops in older, fair-skinned adults.  the average age of diagnosis is 65.  lmm is thought to be caused by a history of sun exposure to the affected area.  treatment includes surgery to remove as much of the lmm as possible. last updated: 11/23/2012

MalaCards based summary: Lentigo Maligna Melanoma, also known as hutchison melanotic freckle, is related to melanoma and basal cell carcinoma. An important gene associated with Lentigo Maligna Melanoma is MC1R (Melanocortin 1 Receptor (Alpha Melanocyte Stimulating Hormone Receptor)), and among its related pathways are Melanocyte Development and Pigmentation and Cell adhesion_ECM remodeling. Affiliated tissues include skin, and related mouse phenotypes are pigmentation and integument.

Wikipedia:68 Lentigo maligna melanoma is a melanoma that has evolved from a lentigo maligna. They are usually found... more...

Related Diseases for Lentigo Maligna Melanoma

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Diseases related to Lentigo Maligna Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1melanoma11.4
2basal cell carcinoma10.6
3superficial spreading melanoma10.6
4gastrointestinal stromal tumor10.3
5burns10.3
6skin disease10.3
7merkel cell carcinoma10.3
8acral lentiginous melanoma10.3
9dermatomyositis10.3
10keratosis10.3
11penis non-invasive verrucous carcinoma10.1MLANA, S100B
12hypodermyiasis10.1MITF, MLANA
13milk allergic reaction10.1MITF, MLANA
14anal margin basal cell carcinoma10.1MITF, MLANA
15malignant melanoma, somatic10.0MC1R, MITF
16fallopian tube teratoma10.0MITF, S100B
17neuroma10.0MITF, S100B
18corneal intraepithelial dyskeratosis and ectodermal dysplasia10.0MITF, MLANA
19talo-patello-scaphoid osteolysis10.0MMP2, MMP9
20retinal drusen10.0MMP2, MMP9
21infiltrating angiolipoma10.0MMP2, MMP9
22carcinoma arising in nasal papillomatosis10.0MMP2, MMP9
23sympathetic ophthalmia10.0MMP2, MMP9
24fibrous meningioma10.0MMP2, MMP9
25bronchiolo-alveolar adenocarcinoma10.0MMP2, MMP9
26hernia of ovary and fallopian tube10.0MMP2, MMP9
27adult botryoid rhabdomyosarcoma10.0MMP2, MMP9
28limb deficiencies distal with micrognathia10.0MMP2, MMP9
29subacute leukemia10.0MMP2, MMP9
30adenosarcoma of the uterus10.0MMP2, MMP9
31lacrimal gland cancer10.0MMP2, MMP9
32coagulation protein disease10.0MMP2, MMP9
33neurofibromatosis, type 210.0MMP2, MMP9
34duodenum adenoma10.0MMP2, MMP9
35coronary stenosis10.0MMP2, MMP9
36conjunctivochalasis10.0MMP2, MMP9
37apocrine adenoma10.0MMP2, MMP9
38intestinal volvulus10.0MMP2, MMP9
39morbid obesity10.0MMP9, S100B
40brachydactyly - arterial hypertension9.9MMP2, MMP9
41fungal meningitis9.9MMP2, MMP9
42ectopic pregnancy9.9MMP2, MMP9
43proximal symphalangism9.9MMP9, S100B
44dyspepsia9.9MMP9, S100B
45balanitis9.9MMP9, S100B
46laryngeal carcinoma9.9MMP2, MMP9
47anterior spinal artery syndrome9.9MITF, MLANA, S100B
48tongue disease9.9MMP2, MMP9
49oral leukoplakia9.9MMP2, MMP9
50keratitis9.9MMP2, MMP9

Graphical network of the top 20 diseases related to Lentigo Maligna Melanoma:



Diseases related to lentigo maligna melanoma

Symptoms for Lentigo Maligna Melanoma

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Drugs & Therapeutics for Lentigo Maligna Melanoma

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Drugs for Lentigo Maligna Melanoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Imiquimodapproved, investigationalPhase 4, Phase 3, Phase 212699011-02-657469
Synonyms:
1-(2-Methylpropyl)-1H-imidazole[4,5-c]quinoline-4-amine
1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine
1-(2-methylpropyl)imidazo[4,5-c]quinolin-4-amine
1-Isobutyl-1H-imidazo[4,5-c]quinolin-4-amine
1-isobutyl-1H-imidazo(4,5-c)quinolin-4-amine
1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine
3M Brand of Imiquimod
4-Amino-1-isobutyl-1H-imidazo(4,5-c)quinoline
4-Amino-1-isobutyl-1H-imidazo[4,5-c]quinoline
99011-02-6
AC-529
AC1L1N2I
AC1Q4YO9
Aldara
Aldara (TN)
Aldara, Imiquimod
BB_SC-2107
BIDD:GT0859
Beselna
C056493
CHEBI:36704
CHEMBL1282
CID57469
D02500
DB00724
DZ-2636
FT-0080222
HMS2090M14
 
I06-0624
I06-2289
I0747
I5159_SIGMA
IMIQUIMOD
Imiquimod
Imiquimod (JAN/USAN/INN)
Imiquimod [USAN:INN]
Imiquimod acetate
Imiquimodum
LS-178395
MLS000083577
MTD-39
MolPort-002-507-845
NCGC00070736-02
NSC369100
R 837
R-837
S 26308
S-26308
S1211_Selleck
SMR000048307
STK583860
TL8006059
TMX-101
UNII-P1QW714R7M
Vyloma
ZINC19632912
Zartra
Zyclara
2
Maleic acidexperimentalPhase 2262110-16-7444972, 444266
Synonyms:
(2Z)-2-Butenedioate
(2Z)-2-Butenedioic acid
(2Z)-Butene-2-dioate
(2Z)-Butene-2-dioic acid
(2Z)-but-2-enedioate
(2Z)-but-2-enedioic acid
(Z)-2-Butenedioate
(Z)-2-Butenedioic acid
(z)-butenedioate
(z)-butenedioic acid
2-Butenedioate
2-Butenedioic acid
Cis-butenedioate
Cis-butenedioic acid
 
H2male
Kyselina maleinova
MAE
Maleate
Maleic acid
Maleic acid [NA2215]
Maleinic acid
Malenic acid
Malezid CM
Scotchbond multipurpose etchant
Toxilic acid
cis-1,2-Ethylenedicarboxylic acid
cis-2-Butenedioate
cis-2-Butenedioic acid
cis-But-2-enedioate
cis-But-2-enedioic acid
3
CediranibPhase 2869933475
Synonyms:
288383-20-0
4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazoline
4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(pyrrolidin-1-yl)propoxy]quinazoline
790713-41-6
AKOS005145767
AZD 2171
AZD-2171
AZD2171
AZD2171, Recentin, Cediranib
CHEMBL491473
CID9933475
 
Cediranib
Cediranib (USAN/INN)
Cediranib maleate
D08881
EC-000.2328
Kinome_3318
M6294
NSC-732208
Recentin
S1017_Selleck
UNII-NQU9IPY4K9
ZD-2171
cediranib
4
Ganciclovirapproved, investigationalPhase 113982410-32-03454
Synonyms:
106931-35-5
107910-75-8 (mono-hydrochloride salt)
2'-NDG
2'-Nor-2'-deoxyguanosine
2-(6-Amino-purin-9-ylmethoxy)-propane-1,3-diol
2-Amino-1,9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-6-H-purin-6-one
2-Amino-9-(2-hydroxy-1-hydroxymethyl-ethoxymethyl)-1,9-dihydro-purin-6-one
2-amino-9-((1,3-Dihydroxypropan-2-yloxy)methyl)-1H-purin-6(9H)-one
2-amino-9-((1,3-Dihydroxypropan-2-yloxy)methyl)-3H-purin-6(9H)-one
2-amino-9-((1,3-Dihydroxypropan-2-yloxy)methyl)-9H-purin-6-ol
2-amino-9-((1,3-dihydroxypropan-2-yloxy)methyl)-1H-purin-6(9H)-one
2-amino-9-((1,3-dihydroxypropan-2-yloxy)methyl)-3H-purin-6(9H)-one
2-amino-9-((1,3-dihydroxypropan-2-yloxy)methyl)-9H-purin-6-ol
2-amino-9-(1,3-dihydroxypropan-2-yloxymethyl)-3H-purin-6-one
2-amino-9-(2-Hydroxy-1-hydroxymethylethoxymethyl)-6,9-dihydro-1H-6-purinone
2-amino-9-(2-hydroxy-1-hydroxymethylethoxymethyl)-6,9-dihydro-1H-6-purinone
2-amino-9-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-1,9-dihydro-6H-purin-6-one
2-amino-9-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-6,9-dihydro-3H-purin-6-one
82410-32-0
86357-12-2
9-((1,3-Dihydroxy-2-propoxy)methyl)guanine
9-((2-Hydroxy-1-(hydroxymethyl)ethoxy)methyl)guanine
9-(1,3-DIHYDROXY-PROPOXYMETHANE)GUANINE
9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine
9-[(1,3-dihydroxy-2-propoxy)methyl]guanine
96551-29-0
AC-12604
AC1L1FZ2
AC1Q52OB
AKOS004119898
BB_NC-1042
BIDD:GT0783
BIOLF-62
BPBio1_000877
BSPBio_000797
BW 759
BW 759U
BW-759U
BW-795
BW-B 759U
Biolf 62
CAS-82410-32-0
CCRIS 9212
CHEBI:465284
CHEMBL182
CID3454
CPD000058324
Citovirax
Cymevan
Cymeven
Cymevene
Cytovene
Cytovene (TN)
Cytovene IV
Cytovene-IV
D00333
DB01004
DRG-0018
EU-0100539
 
G 2536
G2536_SIGMA
GA2
GANCICLOVIR SODIUM
GCV & 1110U81
GCV & MSL
Ganciclovir
Ganciclovir & C34-dgA immunotoxin
Ganciclovir & D5-dgA immunotoxin
Ganciclovir (JAN/USP/INN)
Ganciclovir Sodium
Ganciclovir [USAN:INN:BAN:JAN]
Ganciclovirum
Ganciclovirum [Latin]
Gancyclovir
Guanine, 9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)- and MSL, neutralizing monoclonal antibody
HHEMG
HMS1570H19
HMS2090K08
HSDB 6512
Hydroxyacyclovir
I07-0010
IN1478
LS-73939
Lopac-G-2536
Lopac0_000539
MB3795
MLS000028481
MLS001077349
MolPort-000-758-398
MolPort-002-507-301
NCGC00015471-01
NCGC00015471-02
NCGC00015471-03
NCGC00015471-06
NCGC00093928-01
NCGC00093928-02
NCGC00168567-01
PDSP1_000816
PDSP2_000803
Prestwick0_000839
Prestwick1_000839
Prestwick2_000839
Prestwick3_000839
Prestwick_1068
RS-21592
SAM002548936
SMP2_000038
SMR000058324
SPBio_002718
ST-605
STK801910
UNII-P9G3CKZ4P5
Virgan
Vitrasert
Vitrasert (TN)
ZINC00001505
Zirgan
ganciclovir
nchembio.87-comp3
5
Tazaroteneapproved, investigational38118292-40-35381
Synonyms:
118292-40-3
3-Pyridinecarboxylic acid, 6-((3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl)-, ethyl ester
3-Pyridinecarboxylic acid, 6-((3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl)-,ethyl ester
AC-755
AC1L1K88
AGN 190168
AGN-190168
Avage
Avage (TN)
BIDD:GT0293
C086827
C12531
C21H21NO2S
CHEBI:32184
CHEMBL1657
CID5381
D01132
DB00799
Ethyl 6-((4,4-dimethylthiochroman-6-yl)ethynyl)nicotinate
Fabior
I14-1992
 
LS-130838
MolPort-005-932-693
NCGC00167525-01
S1569_Selleck
S1684_Selleck
Suretin
Tazarotene
Tazarotene (JAN/USAN/INN)
Tazarotene [USAN:INN]
Tazaroteno
Tazarotenum
Tazorac
Tazorac, Avage, Zora, Tazarotene
Tazoral
UNII-81BDR9Y8PS
ZINC01542199
Zorac
ethyl 6-(2-(4,4-dimethylthiochroman-6-yl)ethynyl)nicotinate
ethyl 6-[(4,4-dimethyl-3,4-dihydro-2H-thiochromen-6-yl)ethynyl]nicotinate
ethyl 6-[2-(4,4-dimethyl-2,3-dihydrothiochromen-6-yl)ethynyl]pyridine-3-carboxylate
tazarotene
tazaroteno
tazarotenum

Interventional clinical trials:

(show all 13)
idNameStatusNCT IDPhase
1Effect of Topical Imiquimod on Lentigo MalignaCompletedNCT01161888Phase 4
2Photodynamic Therapy for Lentigo Maligna Using 5-aminolevulinic Acid Nanoemulsion as a Light Sensitizing CreamRecruitingNCT02685592Phase 4
3Relevance of Imiquimod as Neo-adjuvant Treatment to Reduce Excision Size and the Risk of Intralesional Excision in Lentigo Malignant of the FaceRecruitingNCT01720407Phase 3
4Imiquimod to Detect Residual Lesions and Prevent Recurrence of Lentigo MalignaRecruitingNCT01088737Phase 2, Phase 3
5Radiotherapy or Imiquimod in Complex Lentigo MalignaRecruitingNCT02394132Phase 3
6AZD2171 in Treating Patients With Recurrent or Stage IV MelanomaCompletedNCT00243061Phase 2
7Dinaciclib in Treating Patients With Stage IV MelanomaActive, not recruitingNCT00937937Phase 2
8Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Stage IV MelanomaActive, not recruitingNCT01120275Phase 2
9Gene Therapy and Ganciclovir in Treating Patients With Stage IV MelanomaCompletedNCT00005057Phase 1
10In Vivo Confocal Microscopy for Pigmented Lesion DiagnosisCompletedNCT00785369
11Combination Therapy With Imiquimod Cream 5% and Tazarotene Cream 0.1% for the Treatment of Lentigo MalignaCompletedNCT00707174
12Study of Families With MelanomaRecruitingNCT00445783
13Mohs and Immunofluorescence for Malignant Melanoma In SituWithdrawnNCT02306512

Search NIH Clinical Center for Lentigo Maligna Melanoma

Genetic Tests for Lentigo Maligna Melanoma

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Anatomical Context for Lentigo Maligna Melanoma

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MalaCards organs/tissues related to Lentigo Maligna Melanoma:

33
Skin

Animal Models for Lentigo Maligna Melanoma or affiliated genes

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MGI Mouse Phenotypes related to Lentigo Maligna Melanoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.1MC1R, MITF, MLANA
2MP:00107717.6MC1R, MITF, MLANA, MMP9, S100B

Publications for Lentigo Maligna Melanoma

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Articles related to Lentigo Maligna Melanoma:

(show top 50)    (show all 118)
idTitleAuthorsYear
1
Intraoperative real-time reflectance confocal microscopy for guiding surgical margins of lentigo maligna melanoma. (26050216)
2015
2
Lentigo Maligna Melanoma With Local and Distant Blue Nevus-like Metastases. (25943243)
2015
3
Lentigo maligna and lentigo maligna melanoma as occupational skin diseases in a forestry worker with long-standing occupational UV-exposure. (24903264)
2014
4
Delineating Margins of Lentigo Maligna (Melanoma) Using a Hyperspectral Imaging System. (25394551)
2014
5
Distribution of MC1R variants among melanoma subtypes: p.R163Q is associated with lentigo maligna melanoma in a Mediterranean population. (23647022)
2013
6
KIT and BRAF mutational status in a patient with a synchronous lentigo maligna melanoma and a gastrointestinal stromal tumor. (22175303)
2012
7
Lentigo maligna melanoma--the review. (21305747)
2010
8
Matrix metalloproteinases 2 and 9 in lentigo maligna melanoma. (19528914)
2009
9
Staged excision versus Mohs micrographic surgery for lentigo maligna and lentigo maligna melanoma. (17870430)
2007
10
Progression of lentigo maligna into lentigo maligna melanoma following laser treatment. (17478397)
2007
11
Hypomyopathic dermatomyositis associated with lentigo maligna melanoma. (16781317)
2006
12
A collision tumor involving Basal cell carcinoma and lentigo maligna melanoma. (16121053)
2005
13
Management of lentigo maligna and lentigo maligna melanoma with staged excision: a 5-year follow-up. (15148099)
2004
14
Lentigo maligna melanoma. (15624713)
2004
15
A comparison of dermoscopic features among lentigo senilis/initial seborrheic keratosis, seborrheic keratosis, lentigo maligna and lentigo maligna melanoma on the face. (15729860)
2004
16
Surgical margins for lentigo maligna and lentigo maligna melanoma: the technique of mapped serial excision. (15381549)
2004
17
Amelanotic lentigo maligna melanoma. (14724412)
2004
18
Management of early lentigo maligna and lentigo maligna melanoma of the head and neck. (15062292)
2003
19
Parasitism of basal cell carcinoma by lentigo maligna melanoma. (12734489)
2003
20
Topical treatment of lentigo maligna melanoma with imiquimod 5% cream. (14571081)
2003
21
Ultraviolet-assisted punch biopsy mapping for lentigo maligna melanoma. (11352422)
2001
22
Fractionated radiotherapy of lentigo maligna and lentigo maligna melanoma in 64 patients. (10954659)
2000
23
Lentigo maligna melanoma. (10865932)
2000
24
Amelanotic lentigo maligna melanoma: a unique case presentation. (10469082)
1999
25
Amelanotic lentigo maligna melanoma: report of a case and review of the literature. (10431675)
1999
26
Mohs micrographic surgery for lentigo maligna and lentigo maligna melanoma. A follow-up study. (9648576)
1998
27
Extrafacial lentigo maligna melanoma: analysis of 71 cases and comparison with lentigo maligna melanoma of the head and neck. (9767288)
1998
28
Lentigo maligna and lentigo maligna melanoma. (9091498)
1997
29
Lentigo maligna and lentigo maligna melanoma. (9204053)
1997
30
Comparison between lentigo maligna melanoma and other histogenetic types of malignant melanoma of the head and neck. Scottish Melanoma Group. (8611411)
1996
31
Cytodiagnosis of pulmonary metastatic malignant melanoma from lentigo maligna melanoma. (7669930)
1995
32
Amelanotic lentigo maligna melanoma. (7829736)
1995
33
Management of lentigo maligna and lentigo maligna melanoma with tangential paraffin-embedded sections. (8089308)
1994
34
Successful treatment of lentigo maligna and lentigo maligna melanoma with Mohs' micrographic surgery aided by rush permanent sections. (8199993)
1994
35
Angiocentric invasion by lentigo maligna melanoma. (8132839)
1994
36
Management of lentigo maligna and lentigo maligna melanoma with paraffin-embedded tangential sections: utility of immunoperoxidase staining and supplemental vertical sections. (8408795)
1993
37
Metastatic lentigo maligna melanoma. (2299024)
1990
38
The risk of progression of lentigo maligna to lentigo maligna melanoma. (3567069)
1987
39
Microinvasive lentigo maligna melanoma. (3312317)
1987
40
Lentigo maligna melanoma with deep invasion along the mental nerve. (3459796)
1986
41
Lentigo maligna melanoma yields to radiotherapy. (6848821)
1983
42
Conventional fractionated radiotherapy for 51 patients with lentigo maligna and lentigo maligna melanoma. (6863069)
1983
43
Amelanotic lentigo maligna melanoma manifesting as a dermatitislike plaque. (6847222)
1983
44
Treatment of lentigo maligna and lentigo maligna melanoma. (7391322)
1980
45
The radiotherapy of lentigo maligna and lentigo maligna melanoma of the head and neck. (7379026)
1980
46
Tumor conference 21. Lentigo maligna melanoma. (762304)
1979
47
Pagetoid malignant melanoma and lentigo maligna melanoma of toe. A study with the fluorescence method (Falck and Hillarp). (718255)
1978
48
Proceedings: Lentigo-maligna melanoma: an ultrastructural study. (1276041)
1976
49
Tyrosinase activity in three types of the malignant melanoma: superficial spreading melanoma, lentigo maligna melanoma and nodular melanoma. (50762)
1975
50
Lentigo maligna and lentigo-maligna melanoma. (5776171)
1969

Variations for Lentigo Maligna Melanoma

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Expression for genes affiliated with Lentigo Maligna Melanoma

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Search GEO for disease gene expression data for Lentigo Maligna Melanoma.

Pathways for genes affiliated with Lentigo Maligna Melanoma

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GO Terms for genes affiliated with Lentigo Maligna Melanoma

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Biological processes related to Lentigo Maligna Melanoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1pigmentationGO:00434739.9MC1R, MITF
2ephrin receptor signaling pathwayGO:00480139.8MMP2, MMP9
3endodermal cell differentiationGO:00359879.7MMP2, MMP9
4embryo implantationGO:00075669.4MMP2, MMP9
5collagen catabolic processGO:00305749.4MMP2, MMP9

Molecular functions related to Lentigo Maligna Melanoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1metallopeptidase activityGO:00082379.4MMP2, MMP9

Sources for Lentigo Maligna Melanoma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet