MCID: LNT002
MIFTS: 33

Lentigo Maligna Melanoma malady

Rare diseases category

Summaries for Lentigo Maligna Melanoma

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NIH Rare Diseases:41 Lentigo maligna melanoma (lmm) is a type of skin cancer that usually develops in older, fair-skinned adults.  the average age of diagnosis is 65.  lmm is thought to be caused by a history of sun exposure to the affected area.  treatment includes surgery to remove as much of the lmm as possible. last updated: 11/23/2012

MalaCards based summary: Lentigo Maligna Melanoma, also known as hutchison melanotic freckle, is related to melanoma and basal cell carcinoma. An important gene associated with Lentigo Maligna Melanoma is NKX2-1 (NK2 homeobox 1), and among its related pathways are Angiogenesis and AGE/RAGE pathway. The compounds mucicarmine and b 723 have been mentioned in the context of this disorder. Affiliated tissues include skin, and related mouse phenotypes are integument and skeleton.

Wikipedia:63 Lentigo maligna melanoma is a melanoma that has evolved from a lentigo maligna. They are usually found... more...

Aliases & Classifications for Lentigo Maligna Melanoma

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Lentigo Maligna Melanoma, Aliases & Descriptions:

Name: Lentigo Maligna Melanoma 41 60
Hutchison Melanotic Freckle 41
 
Lmm 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Lentigo Maligna Melanoma

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Diseases related to Lentigo Maligna Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 53)
idRelated DiseaseScoreTop Affiliating Genes
1melanoma30.9MLANA, MMP9, MITF, NKX2-1, MMP2, S100B
2basal cell carcinoma10.6
3superficial spreading melanoma10.6
4meningioma, familial10.4S100B
5gastrointestinal stromal tumor10.4
6burns10.4
7skin disease10.4
8acral lentiginous melanoma10.4
9merkel cell carcinoma10.4
10dermatomyositis10.4
11keratosis10.4
12juvenile xanthogranuloma10.2MLANA, S100B
13granular cell tumor10.2MLANA, S100B
14sex cord-gonadal stromal tumor10.2NKX2-1, S100B
15perivascular epithelioid cell tumor10.2MITF, MLANA
16leiomyosarcoma10.2MLANA, S100B
17neuroendocrine tumor10.2S100B, NKX2-1
18angiomyolipoma10.2MITF, MLANA
19vitiligo-associated multiple autoimmune disease susceptibility 110.1MLANA, MITF
20clear cell sarcoma10.1S100B, MITF
21fibrous histiocytoma10.1S100B, MITF
22malignant peripheral nerve sheath tumor10.1MITF, S100B
23neurofibroma10.1MITF, S100B
24stroke, ischemic10.1S100B, MMP9
25lymphangioleiomyomatosis10.1MLANA, MMP2
26neurilemmoma10.1MITF, S100B
27tongue cancer10.1MMP9, MMP2
28conjunctivochalasis10.1MMP2, MMP9
29abdominal aortic aneurysm10.0MMP2, MMP9
30keratitis10.0MMP2, MMP9
31bladder cancer, somatic10.0MMP9, MMP2
32aneurysm10.0MMP9, MMP2
33grade iii astrocytoma10.0MMP9, MMP2
34microphthalmia10.0S100B, MLANA, MITF
35periodontal disease10.0MMP9, MMP2
36giant cell tumor9.9MMP9, MITF, S100B
37oral cancer9.9MMP2, MMP9
38pulmonary fibrosis9.9MMP9, MMP2
39fibrosarcoma9.9MLANA, MMP2, MMP9
40congenital heart disease9.9MMP9, MMP2
41lung cancer susceptibility 39.9MMP9, MMP2, NKX2-1
42endometrial cancer9.8MMP9, MMP2, NKX2-1
43colorectal cancer9.8MMP9, MMP2, NKX2-1
44astrocytoma9.8S100B, MMP9, MMP2
45glioblastoma9.8S100B, MMP2, MMP9
46breast cancer9.8MMP9, NKX2-1, MMP2
47ovarian cancer, somatic9.8MMP9, MLANA, MMP2
48malignant glioma9.7S100B, MMP2, MMP9
49hepatocellular carcinoma9.7NKX2-1, MMP2, MMP9
50lung cancer9.6NKX2-1, MMP2, MMP9

Graphical network of the top 20 diseases related to Lentigo Maligna Melanoma:



Diseases related to lentigo maligna melanoma

Symptoms for Lentigo Maligna Melanoma

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Drugs & Therapeutics for Lentigo Maligna Melanoma

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Drug clinical trials:

Search ClinicalTrials for Lentigo Maligna Melanoma

Search NIH Clinical Center for Lentigo Maligna Melanoma

Genetic Tests for Lentigo Maligna Melanoma

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Anatomical Context for Lentigo Maligna Melanoma

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MalaCards organs/tissues related to Lentigo Maligna Melanoma:

31
Skin

Animal Models for Lentigo Maligna Melanoma or affiliated genes

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MGI Mouse Phenotypes related to Lentigo Maligna Melanoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.2S100B, MITF, MMP9, MLANA
2MP:00053907.8NKX2-1, MITF, MMP2, MMP9

Publications for Lentigo Maligna Melanoma

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Articles related to Lentigo Maligna Melanoma:

(show top 50)    (show all 114)
idTitleAuthorsYear
1
Lentigo maligna and lentigo maligna melanoma as occupational skin diseases in a forestry worker with long-standing occupational UV-exposure. (24903264)
2014
2
Delineating Margins of Lentigo Maligna (Melanoma) Using a Hyperspectral Imaging System. (25394551)
2014
3
Johnson square procedure for lentigo maligna and lentigo maligna melanoma. (24934910)
2014
4
Distribution of MC1R variants among melanoma subtypes: p.R163Q is associated with lentigo maligna melanoma in a Mediterranean population. (23647022)
2013
5
KIT and BRAF mutational status in a patient with a synchronous lentigo maligna melanoma and a gastrointestinal stromal tumor. (22175303)
2012
6
Lentigo maligna melanoma--the review. (21305747)
2010
7
Matrix metalloproteinases 2 and 9 in lentigo maligna melanoma. (19528914)
2009
8
Staged excision versus Mohs micrographic surgery for lentigo maligna and lentigo maligna melanoma. (17870430)
2007
9
Progression of lentigo maligna into lentigo maligna melanoma following laser treatment. (17478397)
2007
10
Hypomyopathic dermatomyositis associated with lentigo maligna melanoma. (16781317)
2006
11
A collision tumor involving Basal cell carcinoma and lentigo maligna melanoma. (16121053)
2005
12
Management of lentigo maligna and lentigo maligna melanoma with staged excision: a 5-year follow-up. (15148099)
2004
13
Lentigo maligna melanoma. (15624713)
2004
14
A comparison of dermoscopic features among lentigo senilis/initial seborrheic keratosis, seborrheic keratosis, lentigo maligna and lentigo maligna melanoma on the face. (15729860)
2004
15
Surgical margins for lentigo maligna and lentigo maligna melanoma: the technique of mapped serial excision. (15381549)
2004
16
Amelanotic lentigo maligna melanoma. (14724412)
2004
17
Management of early lentigo maligna and lentigo maligna melanoma of the head and neck. (15062292)
2003
18
Parasitism of basal cell carcinoma by lentigo maligna melanoma. (12734489)
2003
19
Topical treatment of lentigo maligna melanoma with imiquimod 5% cream. (14571081)
2003
20
Ultraviolet-assisted punch biopsy mapping for lentigo maligna melanoma. (11352422)
2001
21
Fractionated radiotherapy of lentigo maligna and lentigo maligna melanoma in 64 patients. (10954659)
2000
22
Lentigo maligna melanoma. (10865932)
2000
23
Amelanotic lentigo maligna melanoma: a unique case presentation. (10469082)
1999
24
Amelanotic lentigo maligna melanoma: report of a case and review of the literature. (10431675)
1999
25
Lentigo maligna melanoma and excisional biopsy techniques. (10088870)
1999
26
Mohs micrographic surgery for lentigo maligna and lentigo maligna melanoma. A follow-up study. (9648576)
1998
27
Extrafacial lentigo maligna melanoma: analysis of 71 cases and comparison with lentigo maligna melanoma of the head and neck. (9767288)
1998
28
Lentigo maligna and lentigo maligna melanoma. (9091498)
1997
29
Lentigo maligna and lentigo maligna melanoma. (9204053)
1997
30
Comparison between lentigo maligna melanoma and other histogenetic types of malignant melanoma of the head and neck. Scottish Melanoma Group. (8611411)
1996
31
Cytodiagnosis of pulmonary metastatic malignant melanoma from lentigo maligna melanoma. (7669930)
1995
32
Amelanotic lentigo maligna melanoma. (7829736)
1995
33
Management of lentigo maligna and lentigo maligna melanoma with tangential paraffin-embedded sections. (8089308)
1994
34
Successful treatment of lentigo maligna and lentigo maligna melanoma with Mohs' micrographic surgery aided by rush permanent sections. (8199993)
1994
35
Angiocentric invasion by lentigo maligna melanoma. (8132839)
1994
36
Management of lentigo maligna and lentigo maligna melanoma with paraffin-embedded tangential sections: utility of immunoperoxidase staining and supplemental vertical sections. (8408795)
1993
37
Metastatic lentigo maligna melanoma. (2299024)
1990
38
The risk of progression of lentigo maligna to lentigo maligna melanoma. (3567069)
1987
39
Microinvasive lentigo maligna melanoma. (3312317)
1987
40
Lentigo maligna melanoma with deep invasion along the mental nerve. (3459796)
1986
41
Lentigo maligna melanoma yields to radiotherapy. (6848821)
1983
42
Conventional fractionated radiotherapy for 51 patients with lentigo maligna and lentigo maligna melanoma. (6863069)
1983
43
Amelanotic lentigo maligna melanoma manifesting as a dermatitislike plaque. (6847222)
1983
44
Treatment of lentigo maligna and lentigo maligna melanoma. (7391322)
1980
45
The radiotherapy of lentigo maligna and lentigo maligna melanoma of the head and neck. (7379026)
1980
46
Tumor conference 21. Lentigo maligna melanoma. (762304)
1979
47
Pagetoid malignant melanoma and lentigo maligna melanoma of toe. A study with the fluorescence method (Falck and Hillarp). (718255)
1978
48
Proceedings: Lentigo-maligna melanoma: an ultrastructural study. (1276041)
1976
49
Tyrosinase activity in three types of the malignant melanoma: superficial spreading melanoma, lentigo maligna melanoma and nodular melanoma. (50762)
1975
50
Lentigo maligna and lentigo-maligna melanoma. (5776171)
1969

Variations for Lentigo Maligna Melanoma

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Expression for genes affiliated with Lentigo Maligna Melanoma

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Search GEO for disease gene expression data for Lentigo Maligna Melanoma.

Pathways for genes affiliated with Lentigo Maligna Melanoma

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Compounds for genes affiliated with Lentigo Maligna Melanoma

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Compounds related to Lentigo Maligna Melanoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1mucicarmine4310.0NKX2-1, S100B
2b 723439.9S100B, NKX2-1
3flavanol439.5MMP9, MMP2
4cgs-27023a439.5MMP9, MMP2
5methyl selenol439.5MMP9, MMP2
6col 3439.5MMP9, MMP2
7prinomastat439.5MMP9, MMP2
8trapidil439.5MMP2, MMP9
9ilomastat439.5MMP2, MMP9
10lercanidipine43 1210.5MMP2, MMP9
11tranilast439.5MMP9, MMP2
12gelfoam439.4MMP2, MMP9
13latanoprost43 1210.4MMP2, MMP9
14cilomilast439.4MMP2, MMP9
15(4-aminophenyl)mercuric acetate439.4MMP2, MMP9
16uk 383367599.4MMP9, MMP2
17gi 254023x599.4MMP9, MMP2
18gm 6001599.4MMP9, MMP2
19hydroxamate439.4MMP2, MMP9
20marimastat43 59 1211.4MMP2, MMP9
21zoledronic acid439.4MMP2, MMP9
22ciglitazone43 2810.3MMP2, MMP9
238-isoprostane439.3MMP2, MMP9
241,10-phenanthroline43 210.3MMP9, MMP2
25ns 39843 5910.3MMP2, MMP9
26batimastat43 59 1211.3MMP9, MMP2
27silymarin439.2MMP2, MMP9
28formaldehyde43 2410.2MMP9, NKX2-1, S100B
29hydroxyproline43 24 1211.1MMP2, MMP9
30cyclic amp43 2410.1S100B, NKX2-1, MITF
31ivig439.0MMP9, MMP2
323-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide439.0S100B, MMP2, MMP9
33ribonucleic acid439.0NKX2-1, MMP2, MMP9
34erythromycin43 2 49 1211.9MMP9, MMP2
35norepinephrine43 24 1210.9MMP9, MMP2, S100B
36wortmannin438.9MMP9, MMP2, S100B
3712-o-tetradecanoylphorbol 13-acetate438.9MMP9, MMP2, MITF
38proline438.8S100B, MMP2, MMP9
39creatinine438.8S100B, MMP2, MMP9
40ribavirin43 49 1210.7MMP2, MMP9
41aspartate438.7MMP9, MMP2, S100B
42hematoxylin438.7MLANA, MMP9, NKX2-1, S100B
43zinc43 249.6MMP9, MMP2, NKX2-1, S100B
44estrogen438.5S100B, NKX2-1, MMP2, MMP9
45retinoic acid43 249.5MMP9, MMP2, NKX2-1, S100B
46lactate438.5S100B, MMP2, MMP9, MLANA
47glutamate438.4S100B, MITF, MMP2, MMP9
48serine438.3S100B, NKX2-1, MMP2, MMP9
49tyrosine438.1S100B, NKX2-1, MITF, MMP2, MMP9
50paraffin437.6S100B, NKX2-1, MITF, MMP2, MMP9, MLANA

GO Terms for genes affiliated with Lentigo Maligna Melanoma

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Biological processes related to Lentigo Maligna Melanoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix disassemblyGO:00226179.0MMP2, MMP9
2embryo implantationGO:00075668.9MMP2, MMP9
3collagen catabolic processGO:00305748.7MMP2, MMP9

Molecular functions related to Lentigo Maligna Melanoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityGO:00037059.2NKX2-1, MITF
2metalloendopeptidase activityGO:00042229.0MMP2, MMP9
3protein bindingGO:00055157.0S100B, MLANA, MMP9, MMP2, MITF, NKX2-1

Products for genes affiliated with Lentigo Maligna Melanoma

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Sources for Lentigo Maligna Melanoma

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3CDC
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24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet