LMM
MCID: LNT002
MIFTS: 35

Lentigo Maligna Melanoma (LMM) malady

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Lentigo Maligna Melanoma

Aliases & Descriptions for Lentigo Maligna Melanoma:

Name: Lentigo Maligna Melanoma 50 69
Hutchison Melanotic Freckle 50
Lmm 50

Classifications:



Summaries for Lentigo Maligna Melanoma

NIH Rare Diseases : 50 lentigo maligna melanoma (lmm) is a type of skin cancer that usually develops in older, fair-skinned adults.  the average age of diagnosis is 65.  lmm is thought to be caused by a history of sun exposure to the affected area.  treatment includes surgery to remove as much of the lmm as possible. last updated: 11/23/2012

MalaCards based summary : Lentigo Maligna Melanoma, also known as hutchison melanotic freckle, is related to melanoma and basal cell carcinoma. An important gene associated with Lentigo Maligna Melanoma is MC1R (Melanocortin 1 Receptor), and among its related pathways/superpathways are Pathways in cancer and Matrix Metalloproteinases. The drugs Imiquimod and Aminolevulinic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, and related phenotypes are integument and pigmentation

Wikipedia : 71 Lentigo maligna melanoma is a melanoma that has evolved from a lentigo maligna. They are usually found... more...

Related Diseases for Lentigo Maligna Melanoma

Diseases related to Lentigo Maligna Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
id Related Disease Score Top Affiliating Genes
1 melanoma 11.1
2 basal cell carcinoma 10.2
3 superficial spreading melanoma 10.2
4 mediastinitis 10.2 MITF MLANA
5 intracranial embolism 10.2 MITF MLANA
6 external ear basal cell carcinoma 10.2 MITF MLANA
7 mitochondrial encephalomyopathy 10.1 MC1R MMP2
8 pathologic nystagmus 10.1 MITF S100B
9 coronary restenosis 10.1 MITF S100B
10 uterine corpus leiomyomatosis 10.1 MLANA S100B
11 juvenile xanthogranuloma 10.1 MITF S100B
12 facio skeletal genital syndrome rippberger type 10.0 MMP2 MMP9
13 acute tricyclic antidepressant poisoning 10.0 MMP2 MMP9
14 kleptomania 10.0 MMP2 MMP9
15 thymus adenocarcinoma 10.0 MMP2 MMP9
16 spinal meninges cancer 10.0 MMP2 MMP9
17 neonatal hypoxic and ischemic brain injury 10.0 MMP2 MMP9
18 senile atrophy of choroid 10.0 MMP2 MMP9
19 tinea profunda 10.0 MMP2 MMP9
20 nail disorder, nonsyndromic congenital, 7 10.0 MITF MLANA
21 viral meningitis 10.0 MMP2 MMP9
22 lymphocytic colitis 10.0 MMP2 MMP9
23 gastrointestinal stromal tumor 10.0
24 burns 10.0
25 skin disease 10.0
26 dermatomyositis 10.0
27 keratosis 10.0
28 squamous cell carcinoma 10.0
29 merkel cell carcinoma 10.0
30 acral lentiginous melanoma 10.0
31 adenocarcinoma in situ 10.0 MMP2 MMP9
32 corneal staphyloma 10.0 MMP2 MMP9
33 linear porokeratosis 10.0 MMP2 MMP9
34 alpha chain disease 10.0 MC1R MITF MLANA
35 schwannomatosis 10.0 MMP2 MMP9
36 striated muscle rhabdoid tumor 10.0 MMP2 MMP9
37 retinal artery occlusion 10.0 MMP2 MMP9
38 bulbomembranous urethral cancer 10.0 MMP2 MMP9
39 adult neuronal ceroid lipofuscinosis 10.0 MMP2 MMP9
40 maxillary neoplasm 10.0 MMP2 MMP9
41 breast papillary carcinoma 10.0 MMP2 MMP9
42 trichomalacia 10.0 MMP2 MMP9
43 retinal drusen 10.0 MMP2 MMP9
44 severe acute respiratory syndrome 10.0 MMP2 MMP9
45 laryngostenosis 10.0 MMP2 MMP9
46 nodular cutaneous amyloidosis 10.0 MMP2 MMP9
47 sex cord-gonadal stromal tumor 10.0 MC1R MITF MLANA
48 breast abscess 10.0 MMP2 MMP9
49 chronic polyneuropathy 10.0 MMP2 MMP9
50 maxillary sinus cholesteatoma 9.9 MMP2 MMP9

Graphical network of the top 20 diseases related to Lentigo Maligna Melanoma:



Diseases related to Lentigo Maligna Melanoma

Symptoms & Phenotypes for Lentigo Maligna Melanoma

MGI Mouse Phenotypes related to Lentigo Maligna Melanoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.35 MITF MLANA MMP9 S100B MC1R
2 pigmentation MP:0001186 8.8 MC1R MITF MLANA

Drugs & Therapeutics for Lentigo Maligna Melanoma

Drugs for Lentigo Maligna Melanoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Imiquimod Approved, Investigational Phase 4,Phase 3,Phase 2 99011-02-6 57469
2
Aminolevulinic acid Approved Phase 4 106-60-5 137
3 interferons Phase 4,Phase 3,Phase 2
4 Adjuvants, Immunologic Phase 4,Phase 3,Phase 2
5 Dermatologic Agents Phase 4
6 Interferon Inducers Phase 4,Phase 3,Phase 2
7 Photosensitizing Agents Phase 4
8
Cediranib Investigational Phase 2 288383-20-0 9933475
9
Maleic acid Experimental Phase 2 110-16-7 444266
10 Protein Kinase Inhibitors Phase 2
11
Ganciclovir Approved, Investigational Phase 1 82410-32-0 3454
12 Ganciclovir triphosphate Phase 1
13 Nucleic Acid Synthesis Inhibitors Phase 1
14 Anti-Infective Agents Phase 1
15 Antiviral Agents Phase 1
16
Tazarotene Approved, Investigational 118292-40-3 5381
17
Niacin Approved, Investigational, Nutraceutical 59-67-6 938
18
Nicotinamide Approved, Nutraceutical 98-92-0 936
19
Folic Acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
20 Nicotinic Acids
21 Trace Elements
22 Vitamin B Complex
23 Vitamins
24 Keratolytic Agents
25 Micronutrients
26 Folate Nutraceutical
27 Vitamin B3 Nutraceutical
28 Vitamin B9 Nutraceutical

Interventional clinical trials:

(show all 14)
id Name Status NCT ID Phase
1 Effect of Topical Imiquimod on Lentigo Maligna Completed NCT01161888 Phase 4
2 Photodynamic Therapy for Lentigo Maligna Using 5-aminolevulinic Acid Nanoemulsion as a Light Sensitizing Cream Recruiting NCT02685592 Phase 4
3 Relevance of Imiquimod as Neo-adjuvant Treatment to Reduce Excision Size and the Risk of Intralesional Excision in Lentigo Malignant of the Face Recruiting NCT01720407 Phase 3
4 Imiquimod to Detect Residual Lesions and Prevent Recurrence of Lentigo Maligna Recruiting NCT01088737 Phase 2, Phase 3
5 Radiotherapy or Imiquimod in Complex Lentigo Maligna Recruiting NCT02394132 Phase 3
6 AZD2171 in Treating Patients With Recurrent or Stage IV Melanoma Completed NCT00243061 Phase 2
7 Prospective Study of Ingenol Mebutate for Non-invasive Lentigo Melanoma of the Face Recruiting NCT02723721 Phase 2
8 Dinaciclib in Treating Patients With Stage IV Melanoma Active, not recruiting NCT00937937 Phase 2
9 Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Stage IV Melanoma Terminated NCT01120275 Phase 2
10 Gene Therapy and Ganciclovir in Treating Patients With Stage IV Melanoma Completed NCT00005057 Phase 1
11 In Vivo Confocal Microscopy for Pigmented Lesion Diagnosis Completed NCT00785369
12 Combination Therapy With Imiquimod Cream 5% and Tazarotene Cream 0.1% for the Treatment of Lentigo Maligna Completed NCT00707174
13 Study of Families With Melanoma Recruiting NCT00445783
14 Mohs and Immunofluorescence for Malignant Melanoma In Situ Withdrawn NCT02306512

Search NIH Clinical Center for Lentigo Maligna Melanoma

Genetic Tests for Lentigo Maligna Melanoma

Anatomical Context for Lentigo Maligna Melanoma

MalaCards organs/tissues related to Lentigo Maligna Melanoma:

39
Skin

Publications for Lentigo Maligna Melanoma

Articles related to Lentigo Maligna Melanoma:

(show top 50) (show all 127)
id Title Authors Year
1
Staged Excision for Lentigo Maligna and Lentigo Maligna Melanoma: Analysis of Surgical Margins and Long-term Recurrence in 68 Cases from a Single Practice. ( 27386048 )
2016
2
Comparison of MITF and Melan-A Immunohistochemistry During Mohs Surgery for Lentigo Maligna-Type Melanoma In Situ and Lentigo Maligna Melanoma. ( 26771682 )
2016
3
A systematic review on the role of imiquimod in lentigo maligna and lentigo maligna melanoma: need for standardization of treatment schedule and outcome measures. ( 27987308 )
2016
4
Epidemiology of Lentigo Maligna andA Lentigo Maligna Melanoma in theA Netherlands, 1989-2013. ( 27349862 )
2016
5
Lifetime UV exposure and Lentigo Maligna Melanoma. ( 27925150 )
2016
6
Hyperspectral imaging in detecting dermal invasion in lentigo maligna melanoma. ( 28012166 )
2016
7
Extrafacial lentigo maligna melanoma is reported often in Australia, more so at lower latitudes. ( 26820786 )
2016
8
Curative Electrochemotherapy in Lentigo Maligna Melanoma. ( 26861530 )
2015
9
Lentigo Maligna Melanoma With Local and Distant Blue Nevus-like Metastases. ( 25943243 )
2015
10
Intraoperative real-time reflectance confocal microscopy for guiding surgical margins of lentigo maligna melanoma. ( 26050216 )
2015
11
Reviewing Challenges in the Diagnosis and Treatment of Lentigo Maligna and Lentigo-Maligna Melanoma. ( 27182482 )
2015
12
Johnson square procedure for lentigo maligna and lentigo maligna melanoma. ( 24934910 )
2014
13
Delineating Margins of Lentigo Maligna (Melanoma) Using a Hyperspectral Imaging System. ( 25394551 )
2014
14
Lentigo maligna and lentigo maligna melanoma as occupational skin diseases in a forestry worker with long-standing occupational UV-exposure. ( 24903264 )
2014
15
Clinical usefulness of reflectance confocal microscopy in the management of facial lentigo maligna melanoma. ( 24657027 )
2014
16
Clinicopathological characteristics of 270 patients with lentigo maligna and lentigo maligna melanoma: data from a German skin cancer centre. ( 24958545 )
2014
17
Distribution of MC1R variants among melanoma subtypes: p.R163Q is associated with lentigo maligna melanoma in a Mediterranean population. ( 23647022 )
2013
18
Recurrent lentigo maligna melanoma commingling the tumour nests of a basal cell carcinoma. ( 23623186 )
2013
19
Clinical Usefulness of Reflectance Confocal Microscopy in the Management of Facial Lentigo Maligna Melanoma. ( 23642470 )
2013
20
Mohs micrographic surgery for lentigo maligna and lentigo maligna melanoma using Mel-5 immunostaining: an update from the University of Minnesota. ( 24164856 )
2013
21
Dermoscopy of lentigo maligna melanoma: report of 125 cases. ( 22404578 )
2012
22
Geometric staged excision for the treatment of lentigo maligna and lentigo maligna melanoma: a long-term experience with literature review. ( 22782151 )
2012
23
Risk factors for lentigo maligna melanoma compared with superficial spreading melanoma: a case-control study in Australia. ( 22004881 )
2012
24
Surgical and histologic pitfalls in the management of lentigo maligna melanoma. ( 22370566 )
2012
25
The perimeter technique in the surgical treatment of lentigo maligna and lentigo maligna melanoma. ( 22683018 )
2012
26
KIT and BRAF mutational status in a patient with a synchronous lentigo maligna melanoma and a gastrointestinal stromal tumor. ( 22175303 )
2012
27
Grenz ray treatment of lentigo maligna and early lentigo maligna melanoma. ( 22030019 )
2012
28
Treatment of extensive lentigo maligna melanoma of the scalp by brachytherapy moulage technique. ( 20874783 )
2011
29
Lentigo maligna: melanoma in situ on chronically sun-damaged skin. ( 21732771 )
2011
30
Underlying amelanotic lentigo maligna melanoma uncovered after a severe blistering sunburn. ( 20919599 )
2010
31
Lentigo maligna melanoma--the review. ( 21305747 )
2010
32
Matrix metalloproteinases 2 and 9 in lentigo maligna melanoma. ( 19528914 )
2009
33
Atypical fibroxanthoma, lentigo maligna melanoma and squamous cell carcinoma arising in the site of a thermal burn treated with skin grafts. ( 18963287 )
2009
34
Reflectance confocal microscopy of facial lentigo maligna and lentigo maligna melanoma: a preliminary study. ( 19566662 )
2009
35
Staged excision of lentigo maligna and lentigo maligna melanoma: a 10-year experience. ( 19952650 )
2009
36
Lentigo maligna melanoma with folliculotropism: dermoscopic features during rapid progression. ( 19528438 )
2009
37
Staged excision for lentigo maligna and lentigo maligna melanoma: A retrospective analysis of 117 cases. ( 18029055 )
2008
38
Identification of progenitor cancer stem cell in lentigo maligna melanoma. ( 18727808 )
2008
39
Collision tumor composed of Merkel cell carcinoma and lentigo maligna melanoma. ( 18190446 )
2008
40
Progression of lentigo maligna into lentigo maligna melanoma following laser treatment. ( 17478397 )
2007
41
Staged excision versus Mohs micrographic surgery for lentigo maligna and lentigo maligna melanoma. ( 17870430 )
2007
42
Acral lentiginous melanoma versus lentigo maligna melanoma among Iraqi patients. ( 17206300 )
2007
43
Lentigo maligna (melanoma in situ) treated with imiquimod cream 5%: 12 case reports. ( 17388218 )
2007
44
Mohs micrographic surgery for lentigo maligna and lentigo maligna melanoma using Mel-5 immunostaining: University of Minnesota experience. ( 16706765 )
2006
45
Lentigo maligna/lentigo maligna melanoma: current state of diagnosis and treatment. ( 16681656 )
2006
46
Hypomyopathic dermatomyositis associated with lentigo maligna melanoma. ( 16781317 )
2006
47
Conventional histology vs. three-dimensional histology in lentigo maligna melanoma. ( 16445775 )
2006
48
A collision tumor involving Basal cell carcinoma and lentigo maligna melanoma. ( 16121053 )
2005
49
Multimodal in vivo optical imaging, including confocal microscopy, facilitates presurgical margin mapping for clinically complex lentigo maligna melanoma. ( 16225620 )
2005
50
Treatment of lentigo maligna (melanoma in situ) with the immune response modifier imiquimod. ( 15837872 )
2005

Variations for Lentigo Maligna Melanoma

Expression for Lentigo Maligna Melanoma

Search GEO for disease gene expression data for Lentigo Maligna Melanoma.

Pathways for Lentigo Maligna Melanoma

GO Terms for Lentigo Maligna Melanoma

Biological processes related to Lentigo Maligna Melanoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 ephrin receptor signaling pathway GO:0048013 9.4 MMP2 MMP9
2 extracellular matrix disassembly GO:0022617 9.37 MMP2 MMP9
3 collagen catabolic process GO:0030574 9.32 MMP2 MMP9
4 embryo implantation GO:0007566 9.26 MMP2 MMP9
5 pigmentation GO:0043473 9.16 MC1R MITF
6 endodermal cell differentiation GO:0035987 8.96 MMP2 MMP9
7 positive regulation of vascular smooth muscle cell proliferation GO:1904707 8.62 MMP2 MMP9

Sources for Lentigo Maligna Melanoma

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11 DGIdb
16 ExPASy
18 FMA
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34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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42 MeSH
43 MESH via Orphanet
44 MGI
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
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59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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