Leopard Syndrome 1 malady

MalaCards: Leopard Syndrome 1, also known as leopard syndrome, is related to leopard syndrome and braf-related leopard syndrome. An important gene associated with Leopard Syndrome 1 is PTPN11 (protein tyrosine phosphatase, non-receptor type 11).

OMIM: 151100

leopard syndrome 1 33 leopard syndrome 43

Disease types for leopard syndrome family:

leopard syndrome 3	leopard syndrome 2
leopard syndrome 1

Diseases related to leopard syndrome 1 by text searches and GeneDecks gene sharing:

(show all 16)

id	Related Disease	Score	Top Affiliating Genes
1	leopard syndrome	11.1
2	braf-related leopard syndrome	7.4
3	leopard syndrome 3	7.4
4	leopard syndrome 2	7.4
5	ptpn11-related leopard syndrome	7.4
6	raf1-related leopard syndrome	7.4
7	cardiomyopathy	6.8
8	hypertrophic cardiomyopathy	6.8
9	noonan/ costello/ leopard/ cardiofaciocutaneous syndrome(s) (ras/mapk pathway) multi-gene panels	6.8
10	noonan syndrome	5.9
11	noonan-like/multiple giant cell lesion syndrome	5.9
12	neurofibromatosis	5.9
13	acute myelomonocytic leukemia	5.9
14	congenital heart defect	5.9
15	granular cell tumor	5.9
16	myelomonocytic leukemia	5.9

Clinical features from OMIM: 151100

Approved drugs:

Drug clinical trials:

Genes related to leopard syndrome 1 according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	PTPN11	protein tyrosine phosphatase, non-receptor type 11	11.0	Disorders