MCID: LPR001
MIFTS: 62

Lepromatous Leprosy malady

Infectious diseases category

Summaries for Lepromatous Leprosy

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A leprosy that results in early cutaneous lesions which consist of pale macules that are small, diffuse, and symmetric. this form of leprosy is characterized by hypoesthesia over extensor surfaces of the distal extremities, alopecia affecting lateral aspects of the eyebrows, saddle-nose deformity and oral lepromas.

MalaCards: Lepromatous Leprosy, also known as leprosy, lepromatous, is related to leprosy and tuberculoid leprosy. An important gene associated with Lepromatous Leprosy is CD2 (CD2 molecule), and among its related pathways are Cytokines and Inflammatory Response and Th17 Differentiation. The drugs clofazimine and dapsone and the compounds pge2 and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and monocytes, and related mouse phenotypes are respiratory system and renal/urinary system.

Wikipedia:63 Lepromatous leprosy is a skin condition consisting of pale macules. more...

Aliases & Classifications for Lepromatous Leprosy

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

lepromatous leprosy 8
leprosy, lepromatous 60
leprosy lepromatous 44
type l leprosy 8


External Ids:

Disease Ontology8 DOID:10887
MeSH34 D015440
SNOMED-CT56 21560005
ICD9CM27 030.0
ICD1025 A30.5

Related Diseases for Lepromatous Leprosy

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17GeneCards, 18GeneDecks
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Diseases related to Lepromatous Leprosy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 254)
idRelated DiseaseScoreTop Affiliating Genes
1leprosy32.2IL2, TLR2
2tuberculoid leprosy31.1IL10, IL2RA, IFNG
3tuberculosis30.7IL2, IL4, IL12RB1, IL12B, IL18, IL10
4hepatitis30.6F2, IL18, TLR2
5tetanus30.6IL2, IL4, IL10, IL2RA, MBP, IFNG
6sarcoidosis30.6IL2, IL12RB1, IL1RN, IL12B, IL18, IL12RB2
7lupus erythematosus30.5F2, IL18
8leishmaniasis30.5IL4, IL10, IFNGR1, IFNG
9pulmonary tuberculosis30.5IL2, IL4, IL12RB1, IL12B, IL18, IL10
10glomerulonephritis30.4IL1RN, ITGB2, ICAM1
11systemic lupus erythematosus30.3F2, IL2, IL4, IL12RB1, IL1RN, IL12B
12anaplastic large cell lymphoma30.1IL2RA
13alopecia30.1VDR
14mastitis30.1TLR2
15neuropathy30.1MBP
16rhinitis30.1IL4, ICAM1
17periapical granuloma30.1IL4, IL2RA
18myeloid leukemia30.1VDR, ITGB2
19cutaneous leishmaniasis30.1IL10, IFNG
20mycosis fungoides30.1IL2, IL2RA, ITGB2
21myositis30.1IL1RN, ICAM1
22vasculitis30.1F2, ITGB2, ICAM1
23myasthenia gravis30.1IL2, IL4, IL10, MBP, IFNG
24hepatitis b30.1F2, IL12B, IL18, IL10, IL2RA, IFNG
25arthritis30.1IL4, IL1RN, IL18, IL10, VDR, ITGB2
26leukemia30.1IL2, IL4, IL12B, IL2RA, CD2, VDR
27borderline leprosy10.9
28molluscum contagiosum10.4
29chromoblastomycosis10.3
30mononeuritis multiplex10.3
31multicentric reticulohistiocytosis10.3
32sporotrichosis10.3
33vitiligo10.3
34mononeuritis10.3
35syphilis10.3
36neurofibromatosis10.1
37indeterminate leprosy10.1
38bullous pemphigoid10.1
39pure red-cell aplasia10.1
40porphyria cutanea tarda10.1
41coccidioidomycosis10.1
42hypohidrosis10.1
43mucocutaneous leishmaniasis10.1
44macroglobulinemia10.1
45proliferative glomerulonephritis10.1
46immune-complex glomerulonephritis10.1
47atrophic rhinitis10.1
48chronic rhinitis10.1
49rhinosporidiosis10.1
50pemphigus10.1

Graphical network of the top 20 diseases related to Lepromatous Leprosy:



Diseases related to lepromatous leprosy

Clinical Features for Lepromatous Leprosy

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Drugs & Therapeutics for Lepromatous Leprosy

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Lepromatous Leprosy

Drug clinical trials:

Search ClinicalTrials for Lepromatous Leprosy

Search NIH Clinical Center for Lepromatous Leprosy

Search CenterWatch for Lepromatous Leprosy

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Lepromatous Leprosy

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Anatomical Context for Lepromatous Leprosy

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32MalaCards
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MalaCards organs/tissues related to Lepromatous Leprosy:

32
Skin, T cells, Monocytes, Testes, Bone, Bone marrow, Endothelial, Myeloid, Liver, Kidney, Colon, Heart, Retina, Spleen, Lymph node, Eye, Tongue

Animal Models for Lepromatous Leprosy or affiliated genes

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36MGI
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Publications for Lepromatous Leprosy

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50PubMed
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Articles related to Lepromatous Leprosy:

(show top 50)    (show all 529)
idTitleAuthorsYear
1
Borderline lepromatous leprosy with type 1 (downgrading) reaction. (24252148)
2013
2
Indeterminate leprosy and lepromatous index case: four cases in the same family. (24346893)
2013
3
Netherton's syndrome and lepromatous leprosy: a mere coincidence? (23347305)
2013
4
Chronic rhinosinusitis in ex-lepromatous leprosy patients with atrophic rhinitis. (23398842)
2013
5
Allopurinol induced granuloma annulare in a patient of lepromatous leprosy. (23761716)
2013
6
Lack of association between 3' UTR 1188 A/C polymorphism in the IL-12p40 gene and lepromatous leprosy in Sinaloa, Mexico. (21470215)
2012
7
Increased expression of regulatory T cells and down-regulatory molecules in lepromatous leprosy. (22556091)
2012
8
Lepromatous leprosy patients produce antibodies that recognise non-bilayer lipid arrangements containing mycolic acids. (23283460)
2012
9
Multiple loci variable number tandem repeat (VNTR) analysis (MLVA) of Mycobacterium leprae isolates amplified from European archaeological human remains with lepromatous leprosy. (21658464)
2011
10
UVB susceptibility as a risk factor to the development of lepromatous leprosy. (21308307)
2010
11
Borderline lepromatous leprosy with neurofibromatosis. (21063520)
2010
12
Association between the TaqI polymorphism of the vitamin D receptor gene and lepromatous leprosy in a Mexican population sample]. (19180314)
2009
13
A new Mycobacterium species causing diffuse lepromatous leprosy. (19019760)
2008
14
Lepromatous leprosy. (17290718)
2007
15
A clinical trial of ethionamide and prothionamide for treatment of lepromatous leprosy. (16525107)
2006
16
Co-existence of lepromatous leprosy and myasthenia gravis. (16044813)
2005
17
Lepromatous leprosy and reversal reaction in a Micronesian immigrant. (16101878)
2005
18
Lepromatous leprosy in a heart transplant recipient. (14629293)
2003
19
Leg ulcers in active lepromatous leprosy associated with cryoglobulinaemia. (12372082)
2002
20
Cytokine profiles in paraffin-embedded biopsy samples of lepromatous leprosy patients: semi-quantitative measure of cytokine mRNA using RT-PCR. (11875764)
2001
21
Tetanus in a patient with lepromatous leprosy. (11579652)
2001
22
Clofazimine therapy for lepromatous leprosy: a historical perspective. (10065616)
1999
23
Addiction of anti-CD28 antibodies restores PBMC proliferation and IFN-gamma production in lepromatous leprosy patients. (10574615)
1999
24
CT findings in involvement of the paranasal sinuses by lepromatous leprosy. (10396217)
1999
25
Serum sCD23 in patients with lepromatous and tuberculoid leprosy. (9730298)
1998
26
Palmo-plantar nodular lesions in lepromatous leprosy. (9465163)
1997
27
Localized lepromatous leprosy and its response to chemo-immunotherapy. (8112948)
1994
28
Recognition of Mycobacterium leprae antigens with antibodies present in sera from patients with lepromatous leprosy. (7690388)
1993
29
Facial, glossopharyngeal, vagus and hypoglossal nerve palsy in a case of lepromatous leprosy. (8283070)
1993
30
Short-term trial of clofazimine in previously untreated lepromatous leprosy. (1299709)
1992
31
Comment: Positive Mitsuda lepromin reaction in long-term treated lepromatous leprosy and tuberculoid relapse in lepromatous leprosy. (1845302)
1991
32
Cutaneous lymphoma masquerading as lepromatous leprosy. (2319180)
1990
33
Single lesion subpolar lepromatous leprosy and its possible mode of origin. (2659697)
1989
34
Urinary excretion of renal brush-border enzymes in lepromatous leprosy--a preliminary investigation. (2567323)
1989
35
A florid case of borderline-lepromatous leprosy. (3200196)
1988
36
Hyperbaric oxygenation (HBO) as a complementary treatment of patients with multibacillary lepromatous leprosy. (3507902)
1987
37
Cimetidine inhibits suppressor factor production in Ethiopian lepromatous leprosy patients. (3655466)
1987
38
Undernutrition in lepromatous leprosy, Part I. Is is associated with poverty or with disease? (3796182)
1986
39
Lepromin stimulates interleukin-2 production and interleukin-2 receptor expression in situ in lepromatous leprosy patients. (3106736)
1986
40
The number of Mycobacterium leprae in the pretreatment biopsy-specimen does not determine the rate of response of patients with lepromatous leprosy to chemotherapy with acedapsone. (3517535)
1986
41
Natural tetanus immunity in lepromatous leprosy patients. (3746002)
1986
42
Suppressor T lymphocytes from lepromatous leprosy skin lesions. (2944966)
1986
43
Inhibition of antibody-dependent, cell-mediated cytotoxicity by serum from lepromatous leprosy patients. (4020209)
1985
44
Effect of levamisole therapy on lepromin reaction in lepromatous leprosy cases. (3998557)
1985
45
Lepromatous leprosy. (4093951)
1985
46
Double-stranded DNA inhibits cardiolipin-binding activity in lepromatous leprosy patients' sera. (3878859)
1985
47
Study of rheumatic manifestations and serologic abnormalities in patients with lepromatous leprosy. (3877167)
1985
48
Thalidomide enhances defective monocyte function in lepromatous leprosy. (6146029)
1984
49
Once monthly rifampicin (1200 mg) plus daily dapsone (100 mg) and clofazimine (100 mg) in the initial treatment of lepromatous leprosy. (6384381)
1984
50
Lepromatous leprosy presenting as orchitis. (7377141)
1980

Genetic Variations for Lepromatous Leprosy

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Expression for genes affiliated with Lepromatous Leprosy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lepromatous Leprosy

Search GEO for disease gene expression data for Lepromatous Leprosy.

Pathways for genes affiliated with Lepromatous Leprosy

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Sources:
37NCBI BioSystems Database, 52R&D Systems, 29KEGG, 53Reactome, 51QIAGEN, 4Cell Signaling Technology, 12EMD Millipore
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Pathways related to Lepromatous Leprosy according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3IL12B
210.3IL12RB1
310.0IL18, TLR2
49.9IFNGR1, IFNGR2, IFNG
5
Hide members
9.9IFNG, IFNGR1, IFNGR2
69.8IL18, ITGB2, TLR2
79.7IFNG, IL2RA, IL2
8
Development Thrombopoetin signaling via JAK-STAT pathway
Hide members
9.7IL4, IFNG, IL1RN
99.7ICAM1, IFNG, IL2
109.7IFNG, IFNGR2, TLR2, IFNGR1
119.7ICAM1, IFNG, ITGB2
12
Hide members
9.7IL2, IL4, IL2RA
139.6IL18, IFNGR1, IFNG, IFNGR2
149.6TLR2, ITGB2, IL18, IL12B
159.6IL2RA, IL12RB1, IL12RB2, IL12B
169.5IFNGR1, IFNGR2, IFNG, ICAM1
17
Immune response IFN gamma signaling pathway
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9.5ICAM1, IFNGR1, IFNGR2, IFNG
189.5IFNG, IL2RA, IL18, IL2
199.5IFNG, IL2RA, IL4, IL2
20
Hide members
9.5IL4, IFNG, IL2RA, IL2
219.4IL4, IL10, IL2, IFNG
22
Hide members
9.4IL2RA, IL2, IL10, IFNG
239.4IL12B, IL18, IFNG, ITGB2, TLR2
249.4IL4, IFNG, IL2, ICAM1
25
Hide members
9.4IL12RB1, CD2, IL2RA, IL12RB2, IL12B
26
Immune response Bacterial infections in normal airways
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9.4IL1RN, TLR2, IFNG, IFNGR2, IFNGR1
27
Hide members
9.3IL2RA, IL18, IL1RN, IL2
289.3IL12B, ITGB2, IFNG, TLR2, IL10
299.3IL12B, IL2RA, IL12RB2, IL12RB1, IL2
309.3IL2RA, IL10, IL4, IL2
31
Hide members
9.2IL12B, IL12RB1, IL18, CD2, IL12RB2, ITGB2
32
Hide members
9.1IL12RB1, IFNGR2, IFNGR1, CD2, IL2RA, IL12RB2
339.1ICAM1, IFNG, IL10, IL18, IL12B
349.1ICAM1, MBP, IL2, IL4
359.0IFNG, IL4, IL2, IL12B, IL18, IL10
36
Hide members
8.9IL10, IL2, IFNG, IFNGR1, IL12B, IFNGR2
37
Hide members
8.8IL2, IL4, IL2RA, IFNG, TLR2, IFNGR1
38
Hide members
8.7IL12RB2, IL18, IL12B, IL12RB1, ITGB2, IFNGR2
39
Hide members
8.7IL4, ICAM1, IFNGR1, IFNG, IFNGR2, IL2
40
Development PDGF signaling via STATs and NF-kB
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8.6IL12RB1, IL12B, F2, IL18, IL10, IFNG
41
Hide members
8.6IL4, IL12B, IL18, IL12RB1, IL2RA, IL12RB2
42
Hide members
8.5F2, CD2, ITGB2, IL2RA, IL12RB2, IL12B
43
Hide members
8.4ICAM1, IFNGR1, IL18, IFNGR2, IFNG, IL1RN
44
Hide members
8.2IL12RB2, IL18, IL12B, IL12RB1, IL2, IFNGR1
458.2IFNGR2, IL12B, IFNG, IL18, IFNGR1, TLR2
468.1IL2, IL4, IL12RB1, IL12B, IL10, IL12RB2
47
Hide members
8.0TLR2, IFNGR2, IFNG, IFNGR1, ICAM1, IL2RA
48
Hide members
7.8IL18, TLR2, IL12RB1, IL10, IL2, IL12B
49
Hide members
7.7TLR2, IFNGR2, DEFB1, IL2, IL1RN, IL18
50
Hide members
7.4IL4, IL12RB1, IL12B, IL18, IL10, IL12RB2

Compounds for genes affiliated with Lepromatous Leprosy

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 2BitterDB, 24HMDB
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Compounds related to Lepromatous Leprosy according to GeneCards/GeneDecks:

(show top 50)    (show all 144)
idCompoundScoreTop Affiliating Genes
1pge24410.6IL2
2endotoxin4410.5ICAM1
3cycloheximide4410.4TLR2, IL18
4indomethacin44 59 28 1113.3MBP
5gm-csf44 2811.0IL10, IFNG, ICAM1
6amphotericin b449.9IL1RN
7dexamethasone44 49 28 1112.8TLR2, ITGB2, DEFB1, VDR
8prednisolone44 28 1111.8ITGB2, MBP, IL2RA
9alpha-galactosylceramide449.7IFNG, IL10, IL4, IL2
10imiquimod44 28 59 1112.6IL10, IFNG, IL12B, TLR2, IL18
11pentoxifylline44 1110.6IL4, IL1RN, IL12B, IL18, ITGB2
12poly(i-c)449.6IFNG, TLR2, IL12B, IL4, IL18
13ivig449.6IFNG, MBP, IL1RN, ITGB2
14gold sodium thiomalate449.6IL2RA, IFNG, IL1RN, IL2
15cyclophosphamide44 49 1111.5ITGB2, MBP, IL2RA, IL2
16tuberculin449.5IFNG, IL10, IL2RA, IL18
17lipoteichoic acid449.5IL1RN, IL12B, IL18, IL10, TLR2
18interferon gamma449.4IL10, ICAM1, IL4, IL2, IFNG
19mycophenolate mofetil44 49 1111.4IL2RA, IFNG, IL18, IL2, IL10
20natalizumab44 1110.4ICAM1, IL18, IL2RA, IFNG, IL10
21ribavirin44 49 1111.4IL4, IFNG, IL2, IL10, IL18
22glatiramer acetate44 1110.3IL4, IFNG, IL2, IL10, MBP
23tarc449.2IL4, IL10, ICAM1, IFNG, IL18
24il-12449.2IL2, IL10, IL4, IL12RB1, IL12B, IL18
25tacrolimus44 49 1111.2IL2, IL4, IL2RA, VDR, IFNG, TLR2
26thalidomide44 49 59 1112.2IL2, ITGB2, IL18, IL10, IL2RA, IFNG
27polyinosinic-polycytidylic acid449.2IL10, IFNG, IL18, IL12B, IL4, IL2
28infliximab44 49 1111.1IL10, IL4, IL1RN, IL18, IFNG, IL2RA
29vegf449.1IL18, IL1RN, TLR2, ITGB2, IL2RA, IL10
30ccl344 2810.1IL10, IL18, IFNG, TLR2, ICAM1
31allergens449.1IFNG, IL4, IL1RN, IL18, IL10
32ifn-alpha449.0IL18, IL2RA, IL10, IL2, IFNG
33chloroquine44 2 49 28 1113.0IL4, IL1RN, IL18, IL10, IL2, IL2RA
34okt3448.9ICAM1, ITGB2, IL2, IL2RA, IL10, IL4
35herbimycin a44 599.9ICAM1, ITGB2, IFNG, IL2RA, IL4, IL2
36rantes448.9IL2, IL4, IL12B, IL2RA, ITGB2, TLR2
37con a448.9IL2, IL4, IFNG, CD2, IL2RA, IL18
38polymyxin b448.8IL4, IL1RN, IL10, DEFB1, ITGB2, IFNG
39vitamin d448.6VDR, IL1RN, TLR2, IL10, IL12B, IL2RA
40neopterin448.6IL4, IL1RN, IL18, IL10, IL2RA, ICAM1
41ionomycin448.5IL4, IL12RB1, IL10, IL2RA, CD2, ITGB2
42calcitriol44 59 11 2411.4TLR2, IFNG, VDR, IL2RA, IL10, IL4
43simvastatin44 49 59 28 11 2413.3IL18, IL4, F2, IL1RN, IL10, ITGB2
44cyclosporin a44 28 5910.3VDR, IL2RA, ITGB2, MBP, ICAM1, IFNG
45il 10448.2TLR2, IFNG, VDR, IL2RA, IL10, IL18
46histamine44 28 2410.1IFNG, TLR2, ICAM1, ITGB2, IL2RA, IL10
47thymidine44 249.0IL2RA, IFNG, IL4, VDR, CD2, IL2
48sb 20358044 599.0ICAM1, IFNG, TLR2, IL12B, ITGB2, VDR
49retinoic acid44 248.8TLR2, ICAM1, IL1RN, IFNGR2, VDR, DEFB1
50tyrosine447.3IL18, IL1RN, ITGB2, IFNGR1, ICAM1, MBP

GO Terms for genes affiliated with Lepromatous Leprosy

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16Gene Ontology
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Cellular components related to Lepromatous Leprosy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.4IL4, TLR2, IFNG, ICAM1, CD2, IL2RA
2extracellular spaceGO:0056157.6IFNG, ICAM1, IL10, IL18, IL12B, IL1RN
3plasma membraneGO:0058867.5IFNGR2, IFNGR1, ICAM1, MBP, ITGB2, CD2

Biological processes related to Lepromatous Leprosy according to GeneCards/GeneDecks:

(show all 46)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of T-helper 17 cell lineage commitmentGO:200033010.4IL12RB1, IL12B
2interferon-gamma biosynthetic processGO:04209510.4IL12B, IL18
3positive regulation of memory T cell differentiationGO:04338210.4IL12RB1, IL12B
4positive regulation of NK T cell proliferationGO:05114210.3IL12B, IL18
5positive regulation of T-helper 17 type immune responseGO:200031810.3IL12B, IL12RB1
6negative regulation of interleukin-17 productionGO:03270010.3IL12B, IFNG, TLR2
7positive regulation of smooth muscle cell apoptotic processGO:03439310.3IL12B, IFNG
8positive regulation of interleukin-12 productionGO:03273510.3TLR2, IFNG, IL12B
9regulation of T cell homeostatic proliferationGO:04601310.3IL2, IL2RA
10positive regulation of natural killer cell proliferationGO:03281910.3IL18, IL12B
11regulation of interferon-gamma-mediated signaling pathwayGO:06033410.3IFNGR2, IFNG, IFNGR1
12positive regulation of granulocyte macrophage colony-stimulating factor productionGO:03272510.3IL18, IL12B
13positive regulation of T-helper 1 type immune responseGO:00282710.2IL12RB1, IL12B
14defense response to protozoanGO:04283210.2IFNG, IL12B, IL4
15positive regulation of NF-kappaB import into nucleusGO:04234610.2TLR2, IL18, IL12B
16positive regulation of tissue remodelingGO:03410510.2IL18, IL12B, IL2
17positive regulation of interleukin-17 productionGO:03274010.2IL2, IL12B, IL18
18cellular response to interferon-gammaGO:07134610.2IL12RB1, IL12B, IL18
19positive regulation of chemokine biosynthetic processGO:04508010.2IFNG, IL4
20positive regulation of isotype switching to IgG isotypesGO:04830410.2IFNG, IL4, IL2
21regulation of isotype switchingGO:04519110.2IL4, IL10
22positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.1IL12B, IL4, IL2
23positive regulation of T cell proliferationGO:04210210.1IFNG, IL12B, IL4
24positive regulation of MHC class II biosynthetic processGO:04534810.1IFNG, IL10, IL4
25positive regulation of tumor necrosis factor productionGO:03276010.1TLR2, IFNG, IL18, IL12B
26natural killer cell activationGO:03010110.1IL2, IL12B, IL18, CD2
27positive regulation of nitric oxide biosynthetic processGO:04542910.1TLR2, IFNG, ICAM1
28T-helper 1 type immune responseGO:04208810.0IL12B, IL18
29type 2 immune responseGO:04209210.0IL4, IL18, IL10
30negative regulation of growth of symbiont in hostGO:04413010.0TLR2, IFNG, IL10, IL12B
31positive regulation of inflammatory responseGO:05072910.0TLR2, IL18, IL12B, IL2
32negative regulation of nitric oxide biosynthetic processGO:0450199.9IL4, IL10
33positive regulation of T cell differentiationGO:0455829.9IL2RA, IL4
34interferon-gamma-mediated signaling pathwayGO:0603339.9IFNGR2, IFNG, IFNGR1, ICAM1
35negative regulation of interleukin-12 productionGO:0326959.8TLR2, IL10
36positive regulation of interferon-gamma productionGO:0327299.8IL12RB2, IL18, IL12B, IL12RB1, IL2
37cellular response to lipopolysaccharideGO:0712229.8IFNG, ICAM1, IL10, IL12B
38leukocyte migrationGO:0509009.6ICAM1, ITGB2, CD2, F2
39cell-cell signalingGO:0072679.5ITGB2, IL10, IL18, IL2
40cytokine-mediated signaling pathwayGO:0192219.5IFNGR2, IFNG, IFNGR1, ICAM1, IL12RB2, IL12RB1
41positive regulation of activated T cell proliferationGO:0421049.4IL2, IL2RA, IL18, IL12B, IL12RB1, IL4
42cell surface receptor signaling pathwayGO:0071669.4IFNGR2, IFNG, CD2, IL2RA, IL12RB2, F2
43response to drugGO:0424939.3IL4, IL1RN, IL10, ICAM1, IFNG
44regulation of immune responseGO:0507769.3IL4, ITGB2, ICAM1
45positive regulation of transcription from RNA polymerase II promoterGO:0459449.1TLR2, IFNG, VDR, IL10, IL4, IL2
46immune responseGO:0069558.6TLR2, MBP, DEFB1, IL2RA, IL18, IL1RN

Molecular functions related to Lepromatous Leprosy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interferon-gamma receptor activityGO:00490610.0IFNGR1, IFNGR2
2cytokine receptor activityGO:0048969.9IL12RB2, IL12B, IL12RB1
3interleukin-12 receptor bindingGO:0051439.8IL12RB1, IL12B
4receptor activityGO:0048729.5CD2, ITGB2, ICAM1, TLR2
5cytokine activityGO:0051259.1IL2, IL4, IL12B, IL18, IL10, IFNG
6growth factor activityGO:0080839.1IL10, IL12B, IL4, IL2, F2

Products for genes affiliated with Lepromatous Leprosy

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lepromatous Leprosy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet