MCID: LPR001
MIFTS: 59

Lepromatous Leprosy malady

Infectious category

Summaries for Lepromatous Leprosy

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A leprosy that results in early cutaneous lesions which consist of pale macules that are small, diffuse, and symmetric. this form of leprosy is characterized by hypoesthesia over extensor surfaces of the distal extremities, alopecia affecting lateral aspects of the eyebrows, saddle-nose deformity and oral lepromas.

MalaCards: Lepromatous Leprosy, also known as leprosy, lepromatous, is related to tuberculoid leprosy and tuberculosis. An important gene associated with Lepromatous Leprosy is CD2 (CD2 molecule), and among its related pathways are Cytokines and Inflammatory Response and Th17 Differentiation. The drugs clofazimine and dapsone and the compounds pge2 and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and tongue, and related mouse phenotypes are respiratory system and renal/urinary system.

Wikipedia:64 Lepromatous leprosy is a skin condition consisting of pale macules. more...

Aliases & Classifications for Lepromatous Leprosy

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Aliases & Descriptions:

lepromatous leprosy 8
leprosy, lepromatous 61
leprosy lepromatous 45
type l leprosy 8


External Ids:

Disease Ontology8 DOID:10887
MeSH35 D015440
SNOMED-CT57 21560005
ICD9CM27 030.0
ICD1025 A30.5

Related Diseases for Lepromatous Leprosy

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Lepromatous Leprosy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 251)
idRelated DiseaseScoreTop Affiliating Genes
1tuberculoid leprosy31.1IL10, IL2RA, IFNG
2tuberculosis30.7IL2, IL4, IL12RB1, IL12B, IL18, IL10
3tetanus30.6IL2, IL4, IL10, IL2RA, MBP, IFNG
4pulmonary tuberculosis30.5IL2, IL4, IL12RB1, IL12B, IL18, IL10
5systemic lupus erythematosus30.4F2, IL2, IL4, IL12RB1, IL1RN, IL12B
6urticaria30.2ITGB2
7anaplastic large cell lymphoma30.2IL2RA
8alopecia30.2VDR
9periapical granuloma30.2IL4, IL2RA
10cutaneous leishmaniasis30.2IL10, IFNG
11mycosis fungoides30.2IL2, IL2RA, ITGB2
12vasculitis30.2F2, ITGB2, ICAM1
13hepatitis b30.2F2, IL12B, IL18, IL10, IL2RA, IFNG
14hepatitis c30.2F2, IL2, IL4, IL12B, IL18, IL10
15arthritis30.2IL4, IL1RN, IL18, IL10, VDR, ITGB2
16borderline leprosy11.0
17molluscum contagiosum10.5
18n syndrome10.5
19chromoblastomycosis10.3
20mononeuritis multiplex10.3
21multicentric reticulohistiocytosis10.3
22sporotrichosis10.3
23vitiligo10.3
24syphilis10.3
25dysautonomia10.3
26neurofibromatosis10.2
27indeterminate leprosy10.2
28bullous pemphigoid10.2
29porphyria cutanea tarda10.2
30coccidioidomycosis10.2
31netherton syndrome10.2
32hypohidrosis10.2
33mucocutaneous leishmaniasis10.2
34macroglobulinemia10.2
35proliferative glomerulonephritis10.2
36immune-complex glomerulonephritis10.2
37atrophic rhinitis10.2
38chronic rhinitis10.2
39rhinosporidiosis10.2
40pemphigus10.2
41orchitis10.2
42paralytic lagophthalmos10.2
43herpes zoster10.2
44secondary syphilis10.2
45cryptococcosis10.2
46granuloma annulare10.2
47epidermodysplasia verruciformis10.2
48osteoporosis10.2
49amyloidosis10.2
50squamous cell carcinoma10.2

Graphical network of the top 20 diseases related to Lepromatous Leprosy:



Diseases related to lepromatous leprosy

Clinical Features for Lepromatous Leprosy

Drugs & Therapeutics for Lepromatous Leprosy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Lepromatous Leprosy

Drug clinical trials:

Search ClinicalTrials for Lepromatous Leprosy

Search NIH Clinical Center for Lepromatous Leprosy

Search CenterWatch for Lepromatous Leprosy

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Lepromatous Leprosy

Anatomical Context for Lepromatous Leprosy

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Lepromatous Leprosy:

33
Skin, Liver, Tongue, Kidney, Lymph node, Spleen, Bone marrow, Retina, Heart, Colon, Myeloid, Monocytes, T cells, B cells, Endothelial

Animal Models for Lepromatous Leprosy or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Lepromatous Leprosy

Sources:
51PubMed
See all sources

Articles related to Lepromatous Leprosy:

(show top 50)    (show all 529)
idTitleAuthorsYear
1
Basophils infiltrate the skin lesions in lepromatous leprosy. (22513483)
2013
2
Lsr2 of Mycobacterium leprae and its synthetic peptides elicit restitution of T cell responses in erythema nodosum leprosum and reversal reactions in patients with lepromatous leprosy. (23446220)
2013
3
Giant PPD reaction with positive QuantiFERON-TB Gold in a patient with lepromatous leprosy. (23285712)
2012
4
Nodular secondary syphilis simulating lepromatous leprosy. (23614258)
2012
5
Infantile lepromatous leprosy with vulvar localization. (21853663)
2011
6
Localized lepromatous leprosy in household contact of multibacillary disease. (18544298)
2008
7
Mycobacterium leprae in untreated lepromatous leprosy: more than skin deep. (16681612)
2006
8
Lichen scrofulosorum in a patient with lepromatous leprosy after BCG immunotherapy. (16038252)
2005
9
Borderline lepromatous leprosy presenting as a single cutaneous plaque. (16008652)
2005
10
Molluscum contagiosum-like lesions in lepromatous leprosy. (15267197)
2003
11
Multicentric reticulohistiocytosis misdiagnosed as lepromatous leprosy. (15267195)
2003
12
Missense mutations of the interleukin-12 receptor beta 1(IL12RB1) and interferon-gamma receptor 1 (IFNGR1) genes are not associated with susceptibility to lepromatous leprosy in Korea. (12743658)
2003
13
Ocular complications in newly diagnosed borderline lepromatous and lepromatous leprosy patients: baseline profile of the Indian cohort. (12446359)
2002
14
Histological resolution and bacterial clearance with pulse ROM therapy in borderline lepromatous leprosy. (11480321)
2001
15
Chromoblastomycosis simulating lepromatous leprosy. (9614844)
1998
16
Endemic lepromatous leprosy. (9827308)
1998
17
Hemicorporal distribution of lepromatous leprosy in a patient with hemiplegia. (9675480)
1998
18
Anaesthetic considerations in a patient with lepromatous leprosy. (10021961)
1998
19
Autoantibodies in lepromatous leprosy. (12153365)
1994
20
Tongue involvement in lepromatous leprosy. (8425797)
1993
21
Comparative assessment of the leprosy antibody absorption test, Mycobacterium leprae extract enzyme-linked immunosorbent assay, and gelatin particle agglutination test for serodiagnosis of lepromatous leprosy. (8501238)
1993
22
Autoaggressive lepromatous leprosy. (8228449)
1993
23
Lack of expression of intercellular adhesion molecule ICAM-1 in lepromatous leprosy patients. (7512116)
1993
24
Borderline-tuberculoid relapse in lepromatous leprosy. (8341119)
1993
25
High antibody levels to the mycobacterial fibronectin-binding antigen of 30-31 kD in tuberculosis and lepromatous leprosy. (1371953)
1992
26
The systemic influence of recombinant interleukin 2 on the manifestations of lepromatous leprosy. (2007862)
1991
27
CD2 expression and function in lepromatous leprosy. (2474503)
1989
28
Antroscopic study of the maxillary antrum in lepromatous leprosy. (2754320)
1989
29
A report on six cases of histoid variety of lepromatous leprosy in children. (2703740)
1989
30
Radiological study of the paranasal sinuses in lepromatous leprosy. (3192978)
1988
31
The nature and kinetics of a delayed immune response to purified protein derivative of tuberculin in the skin of lepromatous leprosy patients. (3053962)
1988
32
New multidrug regimen with indigenous drugs and dapsone in the treatment of lepromatous leprosy (preliminary report). (3504207)
1987
33
Myelinated and unmyelinated fibers in sural nerve biopsy of a case with lepromatous leprosy--a quantitative approach. (3598284)
1987
34
Severe reactional state in lepromatous leprosy simulating Sweet's syndrome. (3679660)
1987
35
Lepromatous leprosy: follow-up rate in 84 patients. (3784759)
1986
36
Dependence of proliferative activity of lymphocytes on basal levels of lymphocytic cyclic nucleotides in lepromatous leprosy patients. (3011927)
1986
37
Lymphocyte transformation in lepromatous leprosy: a study of the influence of disease activity and symptom duration. (3738597)
1986
38
Superiority of the neonatally thymectomized Lewis rat (NTLR) to monitor a clinical trial in lepromatous leprosy of the two regimens of rifampin and dapsone. (3522770)
1986
39
An HLA-linked gene controls susceptibility to lepromatous leprosy through T cell regulation. (2952854)
1986
40
Prevalence and specificity of the enhancing effect of three types of interleukin 2 on T cell responsiveness in 97 lepromatous leprosy patients of mixed ethnic origin. (2426020)
1986
41
Detection of phenolic glycolipid I in sera from patients with lepromatous leprosy. (3900237)
1985
42
Relapse rate and incidence of dapsone resistance in lepromatous leprosy patients in Addis Ababa: risk factors and effect of short-term supplementary treatment. (2410520)
1985
43
An electron microscopic study on macrophages and lymphocytes in lepromatous and borderline leprosy. (3889192)
1985
44
Giant reactions to tuberculin in lepromatous leprosy patients. (4086918)
1985
45
Von Recklinghausen's disease associated with diffuse lepromatous leprosy--a case report. (3938988)
1985
46
Natural emergence of antigen-reactive T cells in lepromatous leprosy patients during erythema nodosum leprosum. (2933339)
1985
47
Association of HLA specificity LB-E12 (MB1, DC1, MT1) with lepromatous leprosy in a Venezuelan population. (6592792)
1984
48
Oral zinc as an adjunct to dapsone in lepromatous leprosy. (6541200)
1984
49
Transformation from lepromatous to borderline leprosy under clofazimine therapy. (1022964)
1976
50
Mononeuritis multiplex in lepromatous leprosy. (4301578)
1968

Genetic Variations for Lepromatous Leprosy

Expression for genes affiliated with Lepromatous Leprosy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Lepromatous Leprosy

Search GEO for disease gene expression data for Lepromatous Leprosy.

Pathways for genes affiliated with Lepromatous Leprosy

Sources:
38NCBI BioSystems Database, 53R&D Systems, 30KEGG, 54Reactome, 52QIAGEN, 4Cell Signaling Technology, 12EMD Millipore
See all sources

Pathways related to Lepromatous Leprosy according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3IL12B
210.3IL12RB1
310.0IL18, TLR2
49.9IFNGR1, IFNG, IFNGR2
5
Hide members
9.9IFNGR2, IFNG, IFNGR1
69.8IL18, ITGB2, TLR2
79.7IL2, IL2RA, IFNG
8
Development Thrombopoetin signaling via JAK-STAT pathway
Hide members
9.7IL4, IL1RN, IFNG
99.7IFNG, ICAM1, IL2
109.7IFNGR1, IFNG, IFNGR2, TLR2
119.7IFNG, ICAM1, ITGB2
12
Hide members
9.7IL2RA, IL4, IL2
139.6IFNGR2, IFNG, IFNGR1, IL18
149.6TLR2, ITGB2, IL18, IL12B
159.6IL2RA, IL12RB2, IL12B, IL12RB1
16
Immune response IFN gamma signaling pathway
Hide members
9.5IFNGR2, IFNG, IFNGR1, ICAM1
179.5ICAM1, IFNGR1, IFNG, IFNGR2
189.5IFNG, IL2RA, IL18, IL2
199.5IFNG, IL2RA, IL4, IL2
20
Hide members
9.5IFNG, IL2RA, IL4, IL2
219.4IL2, IL4, IL10, IFNG
22
Hide members
9.4IFNG, IL2RA, IL10, IL2
239.4TLR2, IFNG, ITGB2, IL18, IL12B
249.4IL2, IL4, ICAM1, IFNG
25
Hide members
9.4CD2, IL2RA, IL12RB2, IL12B, IL12RB1
26
Immune response Bacterial infections in normal airways
Hide members
9.4TLR2, IFNGR2, IFNG, IFNGR1, IL1RN
27
Hide members
9.3IL2, IL1RN, IL18, IL2RA
289.3IL12B, IL10, ITGB2, IFNG, TLR2
299.3IL2RA, IL12RB2, IL12B, IL12RB1, IL2
309.3IL2, IL4, IL10, IL2RA
31
Hide members
9.2ITGB2, CD2, IL12RB2, IL18, IL12B, IL12RB1
32
Hide members
9.1CD2, IL2RA, IL12RB2, IL12RB1, IFNGR1, IFNGR2
339.1IFNG, ICAM1, IL10, IL18, IL12B
349.1ICAM1, MBP, IL4, IL2
359.0IFNG, IL10, IL18, IL12B, IL4, IL2
36
Hide members
8.9TLR2, IFNGR2, IFNG, IFNGR1, IL10, IL12B
37
Hide members
8.8TLR2, IFNGR2, IFNG, IFNGR1, IL2RA, IL4
38
Hide members
8.7TLR2, IFNGR2, IFNGR1, IL12RB1, IL12B, IL18
39
Hide members
8.7IFNGR2, IFNG, IFNGR1, ICAM1, ITGB2, IL4
40
Development PDGF signaling via STATs and NF-kB
Hide members
8.6IFNG, IL10, IL18, IL12B, IL12RB1, IL2
41
Hide members
8.6IFNG, IL2RA, IL12RB2, IL18, IL12B, IL12RB1
42
Hide members
8.5ITGB2, CD2, IL2RA, IL12RB2, IL12B, IL12RB1
43
Hide members
8.4IFNGR2, IFNG, IFNGR1, ICAM1, IL2RA, IL18
44
Hide members
8.2IL10, IL18, IL12B, IL12RB1, IL2, IL12RB2
458.2TLR2, IFNGR2, IFNG, IFNGR1, ITGB2, VDR
468.1IFNGR2, IFNG, IFNGR1, IL2RA, IL12RB2, IL10
47
Hide members
8.0TLR2, IFNGR2, IFNG, IFNGR1, ICAM1, IL2RA
48
Hide members
7.8IL2RA, CD2, ITGB2, TLR2, IL12RB2, IL10
49
Hide members
7.7TLR2, IFNGR2, IFNG, IFNGR1, ICAM1, ITGB2
50
Hide members
7.4IFNGR2, IFNG, IFNGR1, ICAM1, ITGB2, IL2RA

Compounds for genes affiliated with Lepromatous Leprosy

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 50PharmGKB, 2BitterDB, 24HMDB
See all sources

Compounds related to Lepromatous Leprosy according to GeneCards/GeneDecks:

(show top 50)    (show all 144)
idCompoundScoreTop Affiliating Genes
1pge24510.6IL2
2endotoxin4510.5ICAM1
3cycloheximide4510.4TLR2, IL18
4indomethacin45 60 29 1113.3MBP
5gm-csf45 2911.0IL10, IFNG, ICAM1
6amphotericin b459.9IL1RN
7dexamethasone45 50 29 1112.8TLR2, ITGB2, DEFB1, VDR
8prednisolone45 29 1111.8ITGB2, MBP, IL2RA
9alpha-galactosylceramide459.7IFNG, IL10, IL4, IL2
10imiquimod45 29 60 1112.6IL10, IFNG, IL12B, TLR2, IL18
11pentoxifylline45 1110.6IL4, IL1RN, IL12B, IL18, ITGB2
12poly(i-c)459.6IFNG, TLR2, IL12B, IL4, IL18
13ivig459.6IFNG, MBP, IL1RN, ITGB2
14gold sodium thiomalate459.6IL2RA, IFNG, IL1RN, IL2
15cyclophosphamide45 50 1111.5ITGB2, MBP, IL2RA, IL2
16tuberculin459.5IFNG, IL10, IL2RA, IL18
17lipoteichoic acid459.5IL1RN, IL12B, IL18, IL10, TLR2
18interferon gamma459.4IL10, ICAM1, IL4, IL2, IFNG
19mycophenolate mofetil45 50 1111.4IL2RA, IFNG, IL18, IL2, IL10
20natalizumab45 1110.4ICAM1, IL18, IL2RA, IFNG, IL10
21ribavirin45 50 1111.4IL4, IFNG, IL2, IL10, IL18
22glatiramer acetate45 1110.3IL4, IFNG, IL2, IL10, MBP
23tarc459.2IL4, IL10, ICAM1, IFNG, IL18
24il-12459.2IL2, IL10, IL4, IL12RB1, IL12B, IL18
25tacrolimus45 50 1111.2IL2, IL4, IL2RA, VDR, IFNG, TLR2
26thalidomide45 50 60 1112.2IL2, ITGB2, IL18, IL10, IL2RA, IFNG
27polyinosinic-polycytidylic acid459.2IL10, IFNG, IL18, IL12B, IL4, IL2
28infliximab45 50 1111.1IL10, IL4, IL1RN, IL18, IFNG, IL2RA
29vegf459.1IL18, IL1RN, TLR2, ITGB2, IL2RA, IL10
30ccl345 2910.1IL10, IL18, IFNG, TLR2, ICAM1
31allergens459.1IFNG, IL4, IL1RN, IL18, IL10
32ifn-alpha459.0IL18, IL2RA, IL10, IL2, IFNG
33chloroquine45 2 50 29 1113.0IL4, IL1RN, IL18, IL10, IL2, IL2RA
34okt3458.9ICAM1, ITGB2, IL2, IL2RA, IL10, IL4
35herbimycin a45 609.9ICAM1, ITGB2, IFNG, IL2RA, IL4, IL2
36rantes458.9IL2, IL4, IL12B, IL2RA, ITGB2, TLR2
37con a458.9IL2, IL4, IFNG, CD2, IL2RA, IL18
38polymyxin b458.8IL4, IL1RN, IL10, DEFB1, ITGB2, IFNG
39vitamin d458.6VDR, IL1RN, TLR2, IL10, IL12B, IL2RA
40neopterin458.6IL4, IL1RN, IL18, IL10, IL2RA, ICAM1
41ionomycin458.5IL4, IL12RB1, IL10, IL2RA, CD2, ITGB2
42calcitriol45 60 11 2411.4TLR2, IFNG, VDR, IL2RA, IL10, IL4
43simvastatin45 50 60 29 11 2413.3IL18, IL4, F2, IL1RN, IL10, ITGB2
44cyclosporin a45 29 6010.3VDR, IL2RA, ITGB2, MBP, ICAM1, IFNG
45il 10458.2TLR2, IFNG, VDR, IL2RA, IL10, IL18
46histamine45 29 2410.1IFNG, TLR2, ICAM1, ITGB2, IL2RA, IL10
47thymidine45 249.0IL2RA, IFNG, IL4, VDR, CD2, IL2
48sb 20358045 609.0ICAM1, IFNG, TLR2, IL12B, ITGB2, VDR
49retinoic acid45 248.8TLR2, ICAM1, IL1RN, IFNGR2, VDR, DEFB1
50tyrosine457.3IL18, IL1RN, ITGB2, IFNGR1, ICAM1, MBP

GO Terms for genes affiliated with Lepromatous Leprosy

Sources:
16Gene Ontology
See all sources

Cellular components related to Lepromatous Leprosy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.4IL4, TLR2, IFNG, ICAM1, CD2, IL2RA
2extracellular spaceGO:0056157.6IFNG, ICAM1, IL10, IL18, IL12B, IL1RN
3plasma membraneGO:0058867.5IFNGR2, IFNGR1, ICAM1, MBP, ITGB2, CD2

Biological processes related to Lepromatous Leprosy according to GeneCards/GeneDecks:

(show all 46)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of T-helper 17 cell lineage commitmentGO:200033010.4IL12RB1, IL12B
2interferon-gamma biosynthetic processGO:04209510.4IL12B, IL18
3positive regulation of memory T cell differentiationGO:04338210.4IL12RB1, IL12B
4positive regulation of NK T cell proliferationGO:05114210.3IL12B, IL18
5positive regulation of T-helper 17 type immune responseGO:200031810.3IL12B, IL12RB1
6negative regulation of interleukin-17 productionGO:03270010.3IL12B, IFNG, TLR2
7positive regulation of smooth muscle cell apoptotic processGO:03439310.3IL12B, IFNG
8positive regulation of interleukin-12 productionGO:03273510.3TLR2, IFNG, IL12B
9regulation of T cell homeostatic proliferationGO:04601310.3IL2, IL2RA
10positive regulation of natural killer cell proliferationGO:03281910.3IL18, IL12B
11regulation of interferon-gamma-mediated signaling pathwayGO:06033410.3IFNGR2, IFNG, IFNGR1
12positive regulation of granulocyte macrophage colony-stimulating factor productionGO:03272510.3IL18, IL12B
13positive regulation of T-helper 1 type immune responseGO:00282710.2IL12RB1, IL12B
14defense response to protozoanGO:04283210.2IFNG, IL12B, IL4
15positive regulation of NF-kappaB import into nucleusGO:04234610.2TLR2, IL18, IL12B
16positive regulation of tissue remodelingGO:03410510.2IL18, IL12B, IL2
17positive regulation of interleukin-17 productionGO:03274010.2IL2, IL12B, IL18
18cellular response to interferon-gammaGO:07134610.2IL12RB1, IL12B, IL18
19positive regulation of chemokine biosynthetic processGO:04508010.2IFNG, IL4
20positive regulation of isotype switching to IgG isotypesGO:04830410.2IFNG, IL4, IL2
21regulation of isotype switchingGO:04519110.2IL4, IL10
22positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.1IL12B, IL4, IL2
23positive regulation of T cell proliferationGO:04210210.1IFNG, IL12B, IL4
24positive regulation of MHC class II biosynthetic processGO:04534810.1IFNG, IL10, IL4
25positive regulation of tumor necrosis factor productionGO:03276010.1TLR2, IFNG, IL18, IL12B
26natural killer cell activationGO:03010110.1IL2, IL12B, IL18, CD2
27positive regulation of nitric oxide biosynthetic processGO:04542910.1TLR2, IFNG, ICAM1
28T-helper 1 type immune responseGO:04208810.0IL12B, IL18
29type 2 immune responseGO:04209210.0IL4, IL18, IL10
30negative regulation of growth of symbiont in hostGO:04413010.0TLR2, IFNG, IL10, IL12B
31positive regulation of inflammatory responseGO:05072910.0TLR2, IL18, IL12B, IL2
32negative regulation of nitric oxide biosynthetic processGO:0450199.9IL4, IL10
33positive regulation of T cell differentiationGO:0455829.9IL2RA, IL4
34interferon-gamma-mediated signaling pathwayGO:0603339.9IFNGR2, IFNG, IFNGR1, ICAM1
35negative regulation of interleukin-12 productionGO:0326959.8TLR2, IL10
36positive regulation of interferon-gamma productionGO:0327299.8IL12RB2, IL18, IL12B, IL12RB1, IL2
37cellular response to lipopolysaccharideGO:0712229.8IFNG, ICAM1, IL10, IL12B
38leukocyte migrationGO:0509009.6ICAM1, ITGB2, CD2, F2
39cell-cell signalingGO:0072679.5ITGB2, IL10, IL18, IL2
40cytokine-mediated signaling pathwayGO:0192219.5IFNGR2, IFNG, IFNGR1, ICAM1, IL12RB2, IL12RB1
41positive regulation of activated T cell proliferationGO:0421049.4IL2, IL2RA, IL18, IL12B, IL12RB1, IL4
42cell surface receptor signaling pathwayGO:0071669.4IFNGR2, IFNG, CD2, IL2RA, IL12RB2, F2
43response to drugGO:0424939.3IL4, IL1RN, IL10, ICAM1, IFNG
44regulation of immune responseGO:0507769.3IL4, ITGB2, ICAM1
45positive regulation of transcription from RNA polymerase II promoterGO:0459449.1TLR2, IFNG, VDR, IL10, IL4, IL2
46immune responseGO:0069558.6TLR2, MBP, DEFB1, IL2RA, IL18, IL1RN

Molecular functions related to Lepromatous Leprosy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interferon-gamma receptor activityGO:00490610.0IFNGR1, IFNGR2
2cytokine receptor activityGO:0048969.9IL12RB2, IL12B, IL12RB1
3interleukin-12 receptor bindingGO:0051439.8IL12RB1, IL12B
4receptor activityGO:0048729.5CD2, ITGB2, ICAM1, TLR2
5cytokine activityGO:0051259.1IL2, IL4, IL12B, IL18, IL10, IFNG
6growth factor activityGO:0080839.1IL10, IL12B, IL4, IL2, F2

Products for genes affiliated with Lepromatous Leprosy

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lepromatous Leprosy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet