MCID: LPR001
MIFTS: 55

Lepromatous Leprosy malady

Category: Infectious diseases

Aliases & Classifications for Lepromatous Leprosy

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Aliases & Descriptions for Lepromatous Leprosy:

Name: Lepromatous Leprosy 10 12
Leprosy, Lepromatous 36 65
 
Leprosy Lepromatous 47
Type L Leprosy 10

Classifications:



External Ids:

Disease Ontology10 DOID:10887
ICD1027 A30.5
SNOMED-CT59 21560005
ICD9CM29 030.0
MeSH36 D015440
UMLS65 C0023348

Summaries for Lepromatous Leprosy

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Disease Ontology:10 A leprosy that results in early cutaneous lesions which consist of pale macules that are small, diffuse, and symmetric. This form of leprosy is characterized by hypoesthesia over extensor surfaces of the distal extremities, alopecia affecting lateral aspects of the eyebrows, saddle-nose deformity and oral lepromas.

MalaCards based summary: Lepromatous Leprosy, also known as leprosy, lepromatous, is related to tuberculoid leprosy and porphyria. An important gene associated with Lepromatous Leprosy is TLR2 (Toll Like Receptor 2), and among its related pathways are IL12 signaling mediated by STAT4 and Rheumatoid arthritis. The drugs dapsone and clofazimine have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and liver, and related mouse phenotypes are integument and craniofacial.

Wikipedia:68 Lepromatous leprosy is a skin condition consisting of pale macules. more...

Related Diseases for Lepromatous Leprosy

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Diseases related to Lepromatous Leprosy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 275)
idRelated DiseaseScoreTop Affiliating Genes
1tuberculoid leprosy30.8IFNG, TLR2, TNF
2porphyria30.2IFNG, IFNGR1, TNF
3neurofibromatosis30.1IL4, TLR2
4cryptococcosis30.0IFNG, IL10, IL4
5cutaneous leishmaniasis29.8IFNG, IL10, IL12RB2, TNF
6systemic lupus erythematosus29.6IFNG, IL10, IL2, TNF
7mycosis fungoides28.8IFNG, IL10, IL2, IL4, TNF
8leprosy11.6
9autoimmune oophoritis10.7IFNG, TNF
10non-distal monosomy 10q10.7IFNG, TNF
11hair defect with photosensitivity and mental retardation10.7TLR2, TNF
12punctate palmoplantar keratoderma type 210.7IL10, TNF
13parasitic ichthyosporea infectious disease10.7IFNG, TNF
14anti-hla hyperimmunization10.6TLR2, TNF
15tuberculous uveitis10.6TLR2, TNF
16multifocal lymphangioendotheliomatosis with thrombocytopenia10.6IL10, TNF
17angioid streaks of choroid10.6IFNG, TLR2
18alternating exotropia10.6IL10, TNF
19intermediate congenital nemaline myopathy10.6IFNG, IFNGR1
20atrichia with papular lesions10.6IFNG, TNF
21drug-induced mental disorder10.6IL10, TNF
22epidemic pleurodynia10.5IFNG, IL10
23soft tissue sarcoma childhood10.5IFNG, TNF
24precursor b lymphoblastic lymphoma/leukemia10.5IL10, TNF
25neurotic disorder10.5IFNG, IL10
26occipital lobe neoplasm10.5TLR2, TNF
27prostate transitional cell carcinoma10.5IL10, TNF
28askin's tumor10.5IFNG, IL12RB1
29moderately severe hemophilia a10.5IL10, TNF
30noonan-like/multiple giant cell lesion syndrome10.4IL12B, TLR2, TNF
31astrakhan spotted fever10.4IFNG, IL10, TLR2
32abdominal tuberculosis10.4IFNG, IL10, TLR2
33dysgammaglobulinemia10.4IL10, IL4
34opisthorchiasis10.4IFNG, IL10, TNF
35hypercementosis10.4IFNG, IL10, TNF
36cholera10.4IL10, TLR2, TNF
37ureterocele10.4IL2, TNF
38hydronephrosis10.4IFNG, IL10, TNF
39cytoplasmic body myopathy10.4IFNG, IL10, TNF
40hemorrhagic proctocolitis10.4IFNG, IL10, TNF
41dancing eyes-dancing feet syndrome10.4IFNG, IL10, TNF
42lateral sclerosis10.4IL10, TLR2, TNF
43hemolytic anemia10.4IFNG, IL10, TNF
44peripheral retinal degeneration10.4IFNG, IL10, TNF
45vagus nerve neoplasm10.4IFNG, IL10, TNF
46meningitis10.4IL10, TLR2, TNF
47tracheal stenosis10.4IFNG, IL10, TNF
48spinal polio10.4IFNG, IL2
49skin conditions10.4IL12RB2, TNF
50dentin dysplasia10.4IFNG, IL10, TNF

Graphical network of the top 20 diseases related to Lepromatous Leprosy:



Diseases related to lepromatous leprosy

Symptoms for Lepromatous Leprosy

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Drugs & Therapeutics for Lepromatous Leprosy

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Drugs for Lepromatous Leprosy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Clofazimineapproved, investigationalPhase 4212030-63-92794
Synonyms:
(3Z)-N,5-bis(4-chlorophenyl)-3-[(1-methylethyl)imino]-3,5-dihydrophenazin-2-amine
2030-63-9
3-(p-Chloranilino)-10-(p-chlorophenyl)-2,10-dihydro-2-(isopropylimino)-phenazine
3-(p-Chloranilino)-10-(p-chlorophenyl)-2,10-dihydro-2-(isopropylimino)phenazine
3-(p-Chloranilino)-10-(p-chlorphenyl)-2,10-dihydro-2-(isopropylimino)-phenazin
3-(p-Chloranilino)-10-(p-chlorphenyl)-2,10-dihydro-2-(isopropylimino)-phenazin [German]
3-(p-Chloroanilino)-10-(p-chlorophenyl)-2,10-dihydro-2-(isopropylimino)phenazine
4-25-00-03033 (Beilstein Handbook Reference)
AC1L1EHE
B 663
B 663 (Pharmaceutical)
B 663 (VAN)
B 663, pharmaceutical
B-663
B. 663
B663
BIDD:PXR0147
BPBio1_000585
BRN 0060420
BSPBio_000531
C06915
C27H22Cl2N4
C8895_SIGMA
CAS-2030-63-9
CFZ
CHEBI:3749
CHEBI:730395
CHEMBL1083384
CHEMBL1292
CID2794
CPD000058704
Chlofazimine
Clofazimin
Clofazimina
Clofazimina [INN-Spanish]
Clofazimine
Clofazimine (JAN/USP/INN)
Clofazimine [USAN:INN:BAN]
Clofaziminum
Clofaziminum [INN-Latin]
 
D00278
DB00845
EINECS 217-980-2
G 30320
G-30,320
G-30320
HMS1569K13
HMS2052B05
HMS2093J10
I06-1891
LS-103014
Lampren
Lamprene
Lamprene (TN)
Liposome-encapsulated clofazimine
MLS000028617
MLS001424318
N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-(1-methylethyl)imino)-2-phenazinamine
N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-(isopropylimino)phenazin-2-amine
N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-[(1-methylethyl)imino]-2-phenazinamine
N,5-bis(4-chlorophenyl)-3-(propan-2-ylimino)-3,5-dihydrophenazin-2-amine
N,5-bis(4-chlorophenyl)-3-propan-2-yliminophenazin-2-amine
NCGC00016600-01
NCGC00016600-02
NCGC00179529-01
NSC 141046
NSC-141046
NSC141046
Prestwick0_000376
Prestwick1_000376
Prestwick2_000376
Prestwick3_000376
Prestwick_685
Riminophenazine
SAM001246878
SMP2_000339
SMR000058704
SPBio_002452
ST51014966
UNII-D959AE5USF
clofazimine
2Anti-Bacterial AgentsPhase 49140
3VitaminsPhase 43857
4Anti-Inflammatory AgentsPhase 48478
5Anti-Infective AgentsPhase 417220
6
Nitric Oxideapproved56410102-43-9145068
Synonyms:
(.)NO
(NO)(.)
10102-43-9
14332-28-6
295566_ALDRICH
51005-20-0
51005-21-1
53851-19-7
90452-29-2
AC1L1ADQ
AC1L3QHF
AC1Q6QZ0
AR-1K7463
Bioxyde d'azote
Bioxyde d'azote [French]
C00533
CCRIS 4319
CHEMBL1200689
CHEMBL1234765
CID145068
CID945
D00074
D009569
DB00435
EDRF
EINECS 233-271-0
Endogenous Nitrate Vasodilator
Endothelium-Derived Nitric Oxide
HNO
HSDB 1246
INOmax
INOmax (TN)
Inomax
LS-192158
LS-7547
MolPort-003-929-452
Mononitrogen monoxide
Monoxide, Mononitrogen
Monoxide, Nitrogen
Monoxido de nitrogeno
Monoxyde d'azote
NITRIC-OXIDE
NO
NO(.)
Nitrate Vasodilator, Endogenous
Nitric Oxide, Endothelium Derived
 
Nitric Oxide, Endothelium-Derived
Nitric oxide
Nitric oxide (JAN)
Nitric oxide 10% by volume or more
Nitric oxide trimer
Nitric oxide, compressed [UN1660] [Poison gas]
Nitric oxide, compressed [UN1660] [Poison gas]
Nitrogen monoxide
Nitrogen oxide
Nitrogen oxide (NO)
Nitrogen protoxide
Nitrosyl
Nitrosyl hydride
Nitrosyl hydride ((NO)H)
Nitrosyl radical
Nitroxide radical
Nitroxyl
OHM 11771
Oxide, Nitric
Oxido de nitrogeno(ii)
Oxido nitrico
Oxyde azotique
Oxyde nitrique
Oxyde nitrique [French]
RCRA waste no. P076
Stickmonoxyd
Stickmonoxyd [German]
Stickstoff(II)-oxid
Stickstoff(ii)-oxid
Stickstoffmonoxid
UN 1660
UN1660
UNII-31C4KY9ESH
Vasodilator, Endogenous Nitrate
[NO]
endothelium-derived relaxing factor
monoxido de nitrogeno
monoxyde d'azote
nitric oxide
nitrogen monooxide
nitrogen monoxide
nitrosyl
oxido de nitrogeno(II)
oxido nitrico
oxidonitrogen(.)
oxoazanyl
oxyde azotique
7
Nitroprussideapproved5815078-28-111963622
Synonyms:
13755-38-9 (di-hydrochloride salt, diH20)
14402-89-2 (di-hydrochloride salt)
15078-28-1
C07269
CHEMBL74115
CID11953891
Disodium nitroprusside dihydrate
LS-187044
Nipride
Nitroferricyanide
 
Nitropress
Nitroprusside
Pentacyanidonitrosylferrate(2-)
Sodium Nitroprusside
Sodium nitroferricyanide dihydrate
Sodium nitroprusside
Sodium nitroprusside dihydrate
Sodium nitroprusside extra pure
UNII-169D1260KM
[Fe(CN)5(NO)](2-)
nitroferricyanide
8
Acetylcholineexperimental68951-84-3187
Synonyms:
ACh
Acetyl choline ion
Acetylcholine Chloride
Acetylcholine cation
 
Acetylcholinium: acetyl-Choline
Choline acetate
Choline acetate (ester)
Miochol E
O-Acetylcholine
acetylcholine chloride
9Vasodilator Agents2926
10Pharmaceutical Solutions7004
11Antihypertensive Agents3618
12Cholinergic Agents3243
13Neurotransmitter Agents14795
14Nitric Oxide Donors100

Interventional clinical trials:

idNameStatusNCT IDPhase
1Effect of Additional Clofazimine on Erythema Nodosum Leprosum (ENL) Reactions in LeprosyCompletedNCT01290744Phase 4
2Microcirculatory Impairment in Patients With LeprosyCompletedNCT02085317
3Treatment Protocol for Clofazamine in the Long Term Treatment of LeprosyNo longer availableNCT00852345

Search NIH Clinical Center for Lepromatous Leprosy

Inferred drug relations via UMLS65/NDF-RT43:


Cochrane evidence based reviews: leprosy, lepromatous

Genetic Tests for Lepromatous Leprosy

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Anatomical Context for Lepromatous Leprosy

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MalaCards organs/tissues related to Lepromatous Leprosy:

33
Skin, T cells, Liver, Kidney, Endothelial, Breast, Thyroid

Animal Models for Lepromatous Leprosy or affiliated genes

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MGI Mouse Phenotypes related to Lepromatous Leprosy:

38 (show all 15)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.2IFNG, IFNGR1, IL10, IL4, TLR2, TNF
2MP:00053828.2IFNG, IL10, IL12B, IL4, TNF
3MP:00053858.0IFNG, IFNGR1, IL10, IL12RB2, IL2, TLR2
4MP:00020067.9IFNG, IFNGR1, IL10, IL12B, IL12RB2, IL2
5MP:00053887.8IFNG, IL10, IL12B, IL2, IL4, TLR2
6MP:00053797.6IFNG, IFNGR1, IL10, IL12RB2, IL2, IL4
7MP:00053707.6IFNG, IFNGR1, IL10, IL12RB2, IL2, IL4
8MP:00053897.5HSPD1, IFNG, IFNGR1, IL10, IL2, IL4
9MP:00053907.3IFNG, IFNGR1, IL10, IL12B, IL4, TLR2
10MP:00053847.2HSPD1, IFNG, IFNGR1, IL10, IL2, IL4
11MP:00053816.9IFNG, IFNGR1, IL10, IL12B, IL12RB2, IL2
12MP:00107686.5HSPD1, IFNG, IFNGR1, IL10, IL12B, IL2
13MP:00053766.3IFNG, IFNGR1, IL10, IL12B, IL12RB1, IL12RB2
14MP:00053876.0IFNG, IFNGR1, IL10, IL12B, IL12RB1, IL12RB2
15MP:00053975.8IFNG, IFNGR1, IL10, IL12B, IL12RB1, IL12RB2

Publications for Lepromatous Leprosy

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Articles related to Lepromatous Leprosy:

(show top 50)    (show all 542)
idTitleAuthorsYear
1
Crusted scabies in a patient with lepromatous leprosy. (27183357)
2016
2
Oral manifestation of lepromatous leprosy: diagnosis and management. (24848267)
2014
3
Lepromatous leprosy and perianal tuberculosis: a case report and literature review. (25180030)
2014
4
Lepromatous leprosy treated with combined chemotherapy and immunotherapy (injection BCG): three case reports. (23675902)
2014
5
Borderline lepromatous leprosy with type 1 (downgrading) reaction. (24252148)
2013
6
Deck chair sign in lepromatous leprosy. (24428120)
2013
7
A delayed diagnosis of lepromatous leprosy: pitfalls and clues to early recognition. (22004493)
2011
8
UVB susceptibility as a risk factor to the development of lepromatous leprosy. (21308307)
2010
9
SNP 668C (-44) alters a NF-kappaB1 putative binding site in non-coding strand of human beta-defensin 1 (DEFB1) and is associated with lepromatous leprosy. (19460328)
2009
10
Lepromatous leprosy with erythema nodosum leprosum as immune reconstitution inflammatory syndrome in an HIV-1 infected patient after initiation of antiretroviral therapy. (22132023)
2009
11
Lichen scrofulosorum in a patient with lepromatous leprosy after BCG immunotherapy. (16038252)
2005
12
Histopathological study of apparently normal oral mucosa in lepromatous leprosy. (16375230)
2005
13
Lepromatous leprosy with extensive unusual ulcerations and cachexia. Is it the first case of Lucio's phenomenon from Iran? (15217312)
2004
14
Intra-abdominal, crystal-storing histiocytosis due to clofazimine in a patient with lepromatous leprosy and concurrent carcinoma of the colon. (15282969)
2004
15
Molluscum contagiosum-like lesions in lepromatous leprosy. (15267197)
2003
16
Near-nerve potential in lepromatous leprosy. (14506718)
2003
17
Multicentric reticulohistiocytosis misdiagnosed as lepromatous leprosy. (15267195)
2003
18
Ocular complications in newly diagnosed borderline lepromatous and lepromatous leprosy patients: baseline profile of the Indian cohort. (12446359)
2002
19
Localized linear lesions in lepromatous leprosy. (11898466)
2001
20
Cutaneous cryptococcosis associated with lepromatous leprosy. (11589749)
2001
21
Anetoderma secondary to lepromatous leprosy. (11326598)
2001
22
Increased lipid peroxidation in lepromatous leprosy. (20877051)
2000
23
Fine-needle aspiration cytology of lepromatous leprosy. (9715599)
1998
24
Rare transcripts of interferon-gamma detected in lepromatous leprosy cases. (9614846)
1998
25
Diffuse alopecia of the scalp in borderline-lepromatous leprosy in an Indian patient. (9503871)
1997
26
Abnormalities of the sympathetic skin response in lepromatous leprosy. (8808668)
1996
27
Localized borderline lepromatous leprosy. (8537706)
1995
28
Lymphangiographic evaluation of patients with clinical lepromatous leprosy on clofazimine. (8189086)
1994
29
Tongue involvement in lepromatous leprosy. (8425797)
1993
30
Electrocardiographic alterations in lepromatous leprosy patients with concomitant Trypanosoma cruzi infection. (8228450)
1993
31
Loss of viability of Mycobacterium leprae isolated from nasal secretions of lepromatous leprosy patients following daily rifampicin and DDS therapy. (8127217)
1993
32
Lepromatous leprosy: nasal manifestations and treatment with minocycline. (1543336)
1992
33
A histopathological and immunological profile of a single lesion lepromatous leprosy (LLs). (1802946)
1991
34
Saber tibiae in lepromatous leprosy. (2376687)
1990
35
Histoid lepromas of lepromatous leprosy. (2228377)
1990
36
Single lesion subpolar lepromatous leprosy and its possible mode of origin. (2659697)
1989
37
Mechanisms of Mycobacterium leprae-specific T-cell deficiency in lepromatous leprosy. (3147697)
1988
38
Facies leprosa: resorption of maxillary anterior alveolar bone and the anterior nasal spine in patients with lepromatous leprosy in Mali. (3373085)
1988
39
Estimation of high density lipoprotein cholesterol in the diagnosis of lepromatous leprosy. (3253340)
1988
40
Effect of deoxyfructoserotonin (DFS) on lepromatous leprosy. (2894551)
1988
41
Evidence of cell-mediated immune contrasuppression in lepromatous leprosy: modulation of a putative T contrasuppressor cell-subset. (3133142)
1988
42
Hyperbaric oxygenation (HBO) as a complementary treatment of patients with multibacillary lepromatous leprosy. (3507902)
1987
43
Evaluation of anti-cardiolipin antibody and its cross-reactivity in sera of patients with lepromatous leprosy. (3740940)
1986
44
Failure of specific antigen presentation in lepromatous leprosy. (3702586)
1986
45
Lepromatous leprosy: follow-up rate in 84 patients. (3784759)
1986
46
Lepromatous leprosy: study of some subpopulations of lymphocytes and their functional analysis. (2934039)
1985
47
Preliminary evidence of natural resistance to Mycobacterium bovis (BCG) in lepromatous leprosy. (6373625)
1984
48
Defective production of monocyte-activating cytokines in lepromatous leprosy. (6366107)
1984
49
Mononeuritis multiplex in lepromatous leprosy. (5690422)
1968
50
Mononeuritis multiplex in lepromatous leprosy. (4301578)
1968

Variations for Lepromatous Leprosy

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Expression for genes affiliated with Lepromatous Leprosy

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Search GEO for disease gene expression data for Lepromatous Leprosy.

Pathways for genes affiliated with Lepromatous Leprosy

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Pathways related to Lepromatous Leprosy according to GeneCards Suite gene sharing:

(show all 49)
idSuper pathwaysScoreTop Affiliating Genes
19.9IFNG, IL2
29.5IFNG, TLR2, TNF
3
Show member pathways
9.4IFNG, IL2, TNF
49.4IFNG, IL2, TNF
5
Show member pathways
9.3IFNG, IFNGR1, TNF
69.3IFNG, IFNGR1, TNF
79.2IL10, IL12B, TNF
89.1IFNG, IL10, TLR2, TNF
99.1IFNG, IL10, IL2, TNF
10
Show member pathways
9.1IFNG, IL10, IL2, TNF
119.1HSPD1, IL10, TNF
129.0IFNG, IL2, IL4
139.0IFNG, IL2, IL4
149.0IFNG, IFNGR1, TLR2, TNF
159.0IFNG, IL12B, TLR2, TNF
168.9IFNG, IL10, IL12B, TNF
17
Show member pathways
8.8IFNG, IL12B, IL12RB1, IL12RB2
18
Show member pathways
8.7IL12B, IL12RB1, IL12RB2, IL2
198.7IFNG, IL10, IL2, IL4
208.6HSPD1, IL12B, TLR2, TNF
21
Show member pathways
8.6IFNG, IL2, IL4, TNF
228.6IFNG, IL2, IL4, TNF
238.6IL10, IL4, TLR2, TNF
248.6IFNG, IL10, IL12B, TLR2, TNF
258.3IFNG, IL10, IL12RB2, IL2, IL4
268.3IFNG, IL10, IL2, IL4, TNF
27
Show member pathways
8.3IFNG, IL10, IL2, IL4, TNF
28
Show member pathways
8.2IFNG, IFNGR1, IL4, TLR2, TNF
29
Show member pathways
8.2IFNG, IFNGR1, IL2, IL4, TNF
30
Show member pathways
8.1IFNG, IL10, IL12B, IL12RB1, IL2, TNF
31
Show member pathways
8.0IFNG, IL12B, IL12RB1, IL4, TLR2
32
Show member pathways
7.9IFNG, IFNGR1, IL2, IL4, TLR2, TNF
33
Show member pathways
7.8IFNG, IFNGR1, IL10, IL12B, IL2, TLR2
347.8IFNG, IL10, IL12B, IL2, IL4, TNF
35
Show member pathways
7.8IFNG, IL10, IL12B, IL2, IL4, TNF
367.6IFNG, IFNGR1, IL10, IL12B, IL12RB1, IL12RB2
37
Show member pathways
7.6IFNG, IL12B, IL12RB1, IL12RB2, IL2, IL4
387.5HSPD1, IFNG, IFNGR1, IL10, IL12B, TLR2
397.4IFNG, IL10, IL12RB1, IL12RB2, IL2, IL4
40
Show member pathways
7.4IFNG, IFNGR1, IL12B, IL2, IL4, TLR2
41
Show member pathways
7.3IFNG, IFNGR1, IL10, IL12B, IL4, TLR2
42
Show member pathways
7.3IFNG, IFNGR1, IL12B, IL12RB1, IL12RB2, IL2
43
Show member pathways
7.2IL10, IL12B, IL12RB1, IL12RB2, IL2, IL4
44
Show member pathways
6.9IFNG, IFNGR1, IL10, IL12B, IL12RB1, IL12RB2
45
Show member pathways
6.9IL10, IL12B, IL12RB1, IL12RB2, IL2, IL4
46
Show member pathways
6.8IFNG, IFNGR1, IL10, IL12B, IL12RB1, IL12RB2
47
Show member pathways
6.4IFNG, IFNGR1, IL10, IL12B, IL12RB1, IL12RB2
48
Show member pathways
6.4IFNG, IFNGR1, IL10, IL12B, IL12RB1, IL12RB2
49
Show member pathways
5.5HSPD1, IFNG, IFNGR1, IL10, IL12B, IL12RB1

GO Terms for genes affiliated with Lepromatous Leprosy

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Biological processes related to Lepromatous Leprosy according to GeneCards Suite gene sharing:

(show all 49)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of tumor necrosis factor productionGO:003276010.5IFNG, TLR2
2positive regulation of chemokine productionGO:003272210.5TLR2, TNF
3positive regulation of calcidiol 1-monooxygenase activityGO:006055910.5IFNG, TNF
4positive regulation of membrane protein ectodomain proteolysisGO:005104410.5IFNG, TNF
5receptor biosynthetic processGO:003280010.4IL10, TNF
6negative regulation of cytokine secretion involved in immune responseGO:000274010.4IL10, TNF
7positive regulation of tissue remodelingGO:003410510.4IL12B, IL2
8negative regulation of interleukin-17 productionGO:003270010.3IFNG, IL12B
9positive regulation of interleukin-17 productionGO:003274010.3IL12B, IL2
10protein import into nucleus, translocationGO:000006010.3IFNG, TNF
11negative regulation of interleukin-6 productionGO:003271510.3IL10, TNF
12positive regulation of smooth muscle cell apoptotic processGO:003439310.3IFNG, IL12B
13natural killer cell activationGO:003010110.2IL12B, IL2
14positive regulation of T-helper 17 cell lineage commitmentGO:200033010.2IL12B, IL12RB1
15positive regulation of T-helper 17 type immune responseGO:200031810.2IL12B, IL12RB1
16positive regulation of memory T cell differentiationGO:004338210.1IL12B, IL12RB1
17B cell proliferationGO:004210010.1HSPD1, IL10
18positive regulation of T cell mediated cytotoxicityGO:000191610.1IL12B, IL12RB1
19positive regulation of T-helper 1 type immune responseGO:000282710.1IL12B, IL12RB1
20positive regulation of T cell differentiationGO:004558210.0IL2, IL4
21extrinsic apoptotic signaling pathway in absence of ligandGO:009719210.0IL2, IL4
22positive regulation of mononuclear cell migrationGO:00716779.9IL4, TNF
23positive regulation of B cell proliferationGO:00308909.9IL2, IL4
24type 2 immune responseGO:00420929.9IL10, IL4
25negative regulation of endothelial cell apoptotic processGO:20003529.8IL10, IL4
26negative regulation of nitric oxide biosynthetic processGO:00450199.8IL10, IL4
27cell surface receptor signaling pathwayGO:00071669.7IFNG, IL12RB2, TNF
28positive regulation of cell adhesionGO:00457859.7IFNG, IL12B, TNF
29positive regulation of interleukin-10 productionGO:00327339.7IL12B, IL4
30positive regulation of osteoclast differentiationGO:00456729.6IFNG, IL12B, TNF
31positive regulation of chemokine biosynthetic processGO:00450809.6IFNG, IL4, TNF
32positive regulation of inflammatory responseGO:00507299.6IL12B, IL2, TLR2
33positive regulation of isotype switching to IgG isotypesGO:00483049.5IFNG, IL2, IL4
34negative regulation of growth of symbiont in hostGO:00441309.5IFNG, IL10, IL12B, TNF
35positive regulation of MHC class II biosynthetic processGO:00453489.4IFNG, IL10, IL4
36B cell activationGO:00421139.4HSPD1, IL4
37positive regulation of tyrosine phosphorylation of Stat5 proteinGO:00425239.4IL12B, IL2, IL4
38positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.4IL10, IL4, TNF
39positive regulation of interleukin-12 productionGO:00327359.4HSPD1, IFNG, IL12B, TLR2
40defense response to bacteriumGO:00427429.3IFNG, IL10, TNF
41cellular response to lipopolysaccharideGO:00712229.2IFNG, IL12B, TNF
42positive regulation of protein phosphorylationGO:00019349.1IL2, IL4, TNF
43defense response to protozoanGO:00428329.1IFNG, IL10, IL12B, IL4
44positive regulation of T cell proliferationGO:00421029.1IFNG, IL12B, IL2, IL4
45positive regulation of transcription, DNA-templatedGO:00458939.0IFNG, IL10, IL4, TNF
46positive regulation of interferon-gamma productionGO:00327298.8IL12B, IL12RB1, IL12RB2, IL2, TNF
47negative regulation of apoptotic processGO:00430668.5HSPD1, IL10, IL2, IL4
48positive regulation of transcription from RNA polymerase II promoterGO:00459448.3IFNG, IL10, IL2, IL4, TNF
49immune responseGO:00069558.1IFNG, IL10, IL2, IL4, TLR2, TNF

Sources for Lepromatous Leprosy

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet