MCID: LPR001
MIFTS: 49

Lepromatous Leprosy malady

Category: Infectious diseases

Aliases & Classifications for Lepromatous Leprosy

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Aliases & Descriptions for Lepromatous Leprosy:

Name: Lepromatous Leprosy 10 12
Leprosy, Lepromatous 36 65
 
Leprosy Lepromatous 47
Type L Leprosy 10

Classifications:



External Ids:

Disease Ontology10 DOID:10887
ICD1027 A30.5
SNOMED-CT59 21560005
ICD9CM29 030.0
MeSH36 D015440
UMLS65 C0023348

Summaries for Lepromatous Leprosy

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Disease Ontology:10 A leprosy that results in early cutaneous lesions which consist of pale macules that are small, diffuse, and symmetric. This form of leprosy is characterized by hypoesthesia over extensor surfaces of the distal extremities, alopecia affecting lateral aspects of the eyebrows, saddle-nose deformity and oral lepromas.

MalaCards based summary: Lepromatous Leprosy, also known as leprosy, lepromatous, is related to meningitis and lateral sclerosis. An important gene associated with Lepromatous Leprosy is TLR2 (Toll Like Receptor 2), and among its related pathways are IL12 signaling mediated by STAT4 and Rheumatoid arthritis. The drugs dapsone and clofazimine have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and bone, and related mouse phenotypes are integument and craniofacial.

Wikipedia:68 Lepromatous leprosy is a skin condition consisting of pale macules. more...

Related Diseases for Lepromatous Leprosy

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Diseases related to Lepromatous Leprosy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 545)
idRelated DiseaseScoreTop Affiliating Genes
1meningitis30.6IL10, TLR2, TNF
2lateral sclerosis30.4IL10, TLR2, TNF
3food allergy30.4IFNG, IL10, TNF
4interstitial emphysema30.4HSPD1, IFNG, TLR2
5hidradenitis30.3IL12RB1, TNF
6kearns-sayre syndrome30.2IL10, IL4, TNF
7methylmalonic acidemia30.2IL10, IL4, TNF
8blastomycosis29.9IFNG, IL10, IL4, TNF
9hypoglycemia29.9IFNG, IL2, IL4
10cll/sll29.8IFNG, IL10, IL2, TNF
11systemic lupus erythematosus29.7IFNG, IL10, IL2, TNF
12rheumatoid arthritis29.4IFNG, IL10, IL2, IL4, TLR2, TNF
13pneumocystosis29.4IFNG, IL10, IL2, IL4, TNF
14urethral diverticulum29.3IFNG, IL10, IL2, IL4, TNF
15leprosy10.8
16endotheliitis10.5
17autoimmune oophoritis10.5IFNG, TNF
18non-distal monosomy 10q10.4IFNG, TNF
19hair defect with photosensitivity and mental retardation10.4TLR2, TNF
20lung cancer10.4
21punctate palmoplantar keratoderma type 210.4IL10, TNF
22parasitic ichthyosporea infectious disease10.4IFNG, TNF
23anti-hla hyperimmunization10.4TLR2, TNF
24tuberculous uveitis10.4TLR2, TNF
25breast cancer10.4
26leukemia10.4
27thyroiditis10.4
28neuronitis10.4
29multifocal lymphangioendotheliomatosis with thrombocytopenia10.4IL10, TNF
30angioid streaks of choroid10.4IFNG, TLR2
31alternating exotropia10.4IL10, TNF
32intermediate congenital nemaline myopathy10.4IFNG, IFNGR1
33atrichia with papular lesions10.4IFNG, TNF
34drug-induced mental disorder10.4IL10, TNF
35arthritis10.4
36hepatitis10.4
37epidemic pleurodynia10.4IFNG, IL10
38soft tissue sarcoma childhood10.4IFNG, TNF
39precursor b lymphoblastic lymphoma/leukemia10.3IL10, TNF
40neurotic disorder10.3IFNG, IL10
41occipital lobe neoplasm10.3TLR2, TNF
42prostatitis10.3
43melanoma10.3
44ovarian cancer10.3
45adenoma10.3
46prostate transitional cell carcinoma10.3IL10, TNF
47askin's tumor10.3IFNG, IL12RB1
48tuberculoid leprosy10.3IFNG, TLR2, TNF
49moderately severe hemophilia a10.3IL10, TNF
50noonan-like/multiple giant cell lesion syndrome10.3IL12B, TLR2, TNF

Graphical network of the top 20 diseases related to Lepromatous Leprosy:



Diseases related to lepromatous leprosy

Symptoms for Lepromatous Leprosy

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Drugs & Therapeutics for Lepromatous Leprosy

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Drugs for Lepromatous Leprosy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Clofazimineapproved, investigationalPhase 4212030-63-92794
Synonyms:
(3Z)-N,5-bis(4-chlorophenyl)-3-[(1-methylethyl)imino]-3,5-dihydrophenazin-2-amine
2030-63-9
3-(p-Chloranilino)-10-(p-chlorophenyl)-2,10-dihydro-2-(isopropylimino)-phenazine
3-(p-Chloranilino)-10-(p-chlorophenyl)-2,10-dihydro-2-(isopropylimino)phenazine
3-(p-Chloranilino)-10-(p-chlorphenyl)-2,10-dihydro-2-(isopropylimino)-phenazin
3-(p-Chloranilino)-10-(p-chlorphenyl)-2,10-dihydro-2-(isopropylimino)-phenazin [German]
3-(p-Chloroanilino)-10-(p-chlorophenyl)-2,10-dihydro-2-(isopropylimino)phenazine
4-25-00-03033 (Beilstein Handbook Reference)
AC1L1EHE
B 663
B 663 (Pharmaceutical)
B 663 (VAN)
B 663, pharmaceutical
B-663
B. 663
B663
BIDD:PXR0147
BPBio1_000585
BRN 0060420
BSPBio_000531
C06915
C27H22Cl2N4
C8895_SIGMA
CAS-2030-63-9
CFZ
CHEBI:3749
CHEBI:730395
CHEMBL1083384
CHEMBL1292
CID2794
CPD000058704
Chlofazimine
Clofazimin
Clofazimina
Clofazimina [INN-Spanish]
Clofazimine
Clofazimine (JAN/USP/INN)
Clofazimine [USAN:INN:BAN]
Clofaziminum
Clofaziminum [INN-Latin]
 
D00278
DB00845
EINECS 217-980-2
G 30320
G-30,320
G-30320
HMS1569K13
HMS2052B05
HMS2093J10
I06-1891
LS-103014
Lampren
Lamprene
Lamprene (TN)
Liposome-encapsulated clofazimine
MLS000028617
MLS001424318
N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-(1-methylethyl)imino)-2-phenazinamine
N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-(isopropylimino)phenazin-2-amine
N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-[(1-methylethyl)imino]-2-phenazinamine
N,5-bis(4-chlorophenyl)-3-(propan-2-ylimino)-3,5-dihydrophenazin-2-amine
N,5-bis(4-chlorophenyl)-3-propan-2-yliminophenazin-2-amine
NCGC00016600-01
NCGC00016600-02
NCGC00179529-01
NSC 141046
NSC-141046
NSC141046
Prestwick0_000376
Prestwick1_000376
Prestwick2_000376
Prestwick3_000376
Prestwick_685
Riminophenazine
SAM001246878
SMP2_000339
SMR000058704
SPBio_002452
ST51014966
UNII-D959AE5USF
clofazimine
2Anti-Bacterial AgentsPhase 49140
3VitaminsPhase 43857
4Anti-Inflammatory AgentsPhase 48478
5Anti-Infective AgentsPhase 417220
6
Nitric Oxideapproved56410102-43-9145068
Synonyms:
(.)NO
(NO)(.)
10102-43-9
14332-28-6
295566_ALDRICH
51005-20-0
51005-21-1
53851-19-7
90452-29-2
AC1L1ADQ
AC1L3QHF
AC1Q6QZ0
AR-1K7463
Bioxyde d'azote
Bioxyde d'azote [French]
C00533
CCRIS 4319
CHEMBL1200689
CHEMBL1234765
CID145068
CID945
D00074
D009569
DB00435
EDRF
EINECS 233-271-0
Endogenous Nitrate Vasodilator
Endothelium-Derived Nitric Oxide
HNO
HSDB 1246
INOmax
INOmax (TN)
Inomax
LS-192158
LS-7547
MolPort-003-929-452
Mononitrogen monoxide
Monoxide, Mononitrogen
Monoxide, Nitrogen
Monoxido de nitrogeno
Monoxyde d'azote
NITRIC-OXIDE
NO
NO(.)
Nitrate Vasodilator, Endogenous
Nitric Oxide, Endothelium Derived
 
Nitric Oxide, Endothelium-Derived
Nitric oxide
Nitric oxide (JAN)
Nitric oxide 10% by volume or more
Nitric oxide trimer
Nitric oxide, compressed [UN1660] [Poison gas]
Nitric oxide, compressed [UN1660] [Poison gas]
Nitrogen monoxide
Nitrogen oxide
Nitrogen oxide (NO)
Nitrogen protoxide
Nitrosyl
Nitrosyl hydride
Nitrosyl hydride ((NO)H)
Nitrosyl radical
Nitroxide radical
Nitroxyl
OHM 11771
Oxide, Nitric
Oxido de nitrogeno(ii)
Oxido nitrico
Oxyde azotique
Oxyde nitrique
Oxyde nitrique [French]
RCRA waste no. P076
Stickmonoxyd
Stickmonoxyd [German]
Stickstoff(II)-oxid
Stickstoff(ii)-oxid
Stickstoffmonoxid
UN 1660
UN1660
UNII-31C4KY9ESH
Vasodilator, Endogenous Nitrate
[NO]
endothelium-derived relaxing factor
monoxido de nitrogeno
monoxyde d'azote
nitric oxide
nitrogen monooxide
nitrogen monoxide
nitrosyl
oxido de nitrogeno(II)
oxido nitrico
oxidonitrogen(.)
oxoazanyl
oxyde azotique
7
Nitroprussideapproved5815078-28-111963622
Synonyms:
13755-38-9 (di-hydrochloride salt, diH20)
14402-89-2 (di-hydrochloride salt)
15078-28-1
C07269
CHEMBL74115
CID11953891
Disodium nitroprusside dihydrate
LS-187044
Nipride
Nitroferricyanide
 
Nitropress
Nitroprusside
Pentacyanidonitrosylferrate(2-)
Sodium Nitroprusside
Sodium nitroferricyanide dihydrate
Sodium nitroprusside
Sodium nitroprusside dihydrate
Sodium nitroprusside extra pure
UNII-169D1260KM
[Fe(CN)5(NO)](2-)
nitroferricyanide
8
Acetylcholineexperimental68951-84-3187
Synonyms:
ACh
Acetyl choline ion
Acetylcholine Chloride
Acetylcholine cation
 
Acetylcholinium: acetyl-Choline
Choline acetate
Choline acetate (ester)
Miochol E
O-Acetylcholine
acetylcholine chloride
9Vasodilator Agents2926
10Pharmaceutical Solutions7004
11Antihypertensive Agents3618
12Cholinergic Agents3243
13Neurotransmitter Agents14795
14Nitric Oxide Donors100

Interventional clinical trials:

idNameStatusNCT IDPhase
1Effect of Additional Clofazimine on Erythema Nodosum Leprosum (ENL) Reactions in LeprosyCompletedNCT01290744Phase 4
2Microcirculatory Impairment in Patients With LeprosyCompletedNCT02085317
3Treatment Protocol for Clofazamine in the Long Term Treatment of LeprosyNo longer availableNCT00852345

Search NIH Clinical Center for Lepromatous Leprosy

Inferred drug relations via UMLS65/NDF-RT43:


Cochrane evidence based reviews: leprosy, lepromatous

Genetic Tests for Lepromatous Leprosy

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Anatomical Context for Lepromatous Leprosy

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MalaCards organs/tissues related to Lepromatous Leprosy:

33
Skin, Breast, Bone, Endothelial, Liver, T cells, Smooth muscle

Animal Models for Lepromatous Leprosy or affiliated genes

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MGI Mouse Phenotypes related to Lepromatous Leprosy:

38 (show all 15)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.2IFNG, IFNGR1, IL10, IL4, TLR2, TNF
2MP:00053828.2IFNG, IL10, IL12B, IL4, TNF
3MP:00053858.0IFNG, IFNGR1, IL10, IL12RB2, IL2, TLR2
4MP:00020067.9IFNG, IFNGR1, IL10, IL12B, IL12RB2, IL2
5MP:00053887.8IFNG, IL10, IL12B, IL2, IL4, TLR2
6MP:00053797.6IFNG, IFNGR1, IL10, IL12RB2, IL2, IL4
7MP:00053707.6IFNG, IFNGR1, IL10, IL12RB2, IL2, IL4
8MP:00053897.5HSPD1, IFNG, IFNGR1, IL10, IL2, IL4
9MP:00053907.3IFNG, IFNGR1, IL10, IL12B, IL4, TLR2
10MP:00053847.2HSPD1, IFNG, IFNGR1, IL10, IL2, IL4
11MP:00053816.9IFNG, IFNGR1, IL10, IL12B, IL12RB2, IL2
12MP:00107686.5HSPD1, IFNG, IFNGR1, IL10, IL12B, IL2
13MP:00053766.3IFNG, IFNGR1, IL10, IL12B, IL12RB1, IL12RB2
14MP:00053876.0IFNG, IFNGR1, IL10, IL12B, IL12RB1, IL12RB2
15MP:00053975.8IFNG, IFNGR1, IL10, IL12B, IL12RB1, IL12RB2

Publications for Lepromatous Leprosy

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Articles related to Lepromatous Leprosy:

(show top 50)    (show all 535)
idTitleAuthorsYear
1
Atypical Acute Posterior Multifocal Placoid Pigment Epitheliopathy. (26583798)
2016
2
Polycystic ovary syndrome (PCOS) with melanocytic mucosal macules: the role of STK11 gene polymorphisms in PCOS and Peutz-Jeghers syndrome. (26147831)
2015
3
Hepatitis E virus antibody prevalence in hunters from a district in Central Germany, 2013: a cross-sectional study providing evidence for the benefit of protective gloves during disembowelling of wild boars. (26493830)
2015
4
Correction: Hepatitis B virus infection and immunopathogenesis in a humanized mouse model: induction of human-specific liver fibrosis and M2-like macrophages. (25781615)
2015
5
Serum Dickkopf-1 as a Biomarker for the Diagnosis of Hepatocellular Carcinoma. (26256972)
2015
6
Retinoic acid-related orphan receptor RORI^, circadian rhythm abnormalities and tumorigenesis (Review). (25816151)
2015
7
Cytoreductive Surgery and HIPEC as a Treatment Option for Laparoscopic Resection of Uterine Leiomyosarcoma with Morcellation: Early Results. (26545375)
2015
8
Enigmatic ectopic fat: prevalence of nonalcoholic fatty pancreas disease and its associated factors in a Chinese population. (24572250)
2014
9
Ubiquitin-like protein ISG15 (interferon-stimulated gene of 15 kDa) in host defense against heart failure in a mouse model of virus-induced cardiomyopathy. (25165091)
2014
10
Effects of anti-inflammatory and Rehmanniae radix pharmacopuncture on atopic dermatitis in NC/Nga mice. (23591005)
2013
11
CDK9-dependent transcriptional elongation in the innate interferon-stimulated gene response to respiratory syncytial virus infection in airway epithelial cells. (23596302)
2013
12
Occupational contact dermatitis to methacrylates in an orthopaedic operating room nurse. (23964562)
2013
13
Large copy number variations in combination with point mutations in the TYMP and SCO2 genes found in two patients with mitochondrial disorders. (23838601)
2013
14
Intraocular lens power calculations for cataract surgery after phototherapeutic keratectomy in granular corneal dystrophy type 2. (23062002)
2012
15
Genetics and genomics in pediatric septic shock. (22511139)
2012
16
Contribution of IL-17 to mouse hepatitis virus strain 3-induced acute liver failure. (22886969)
2012
17
Neurotensin receptor 1 gene (NTSR1) polymorphism is associated with working memory. (21394204)
2011
18
Serum levels of BAFF and APRIL in myeloperoxidase anti-neutrophil cytoplasmic autoantibody-associated renal vasculitis: association with disease activity. (21293157)
2011
19
Type I interferon pathway in adult and juvenile dermatomyositis. (22192711)
2011
20
Leptin G-2548A and leptin receptor Q223R gene polymorphisms are not associated with obesity in Romanian subjects. (19913498)
2010
21
Type I collagen biomarkers in the diagnosis of bone metastases in breast cancer, lung cancer, urinary bladder cancer and prostate cancer. Comparison to CEA, CA 15-3, PSA and bone scintigraphy. (19810140)
2009
22
Nocturnal aspects of narcolepsy with cataplexy. (18282773)
2008
23
SCN2A mutations and benign familial neonatal-infantile seizures: the phenotypic spectrum. (17386050)
2007
24
Nephroblastoma overexpressed (Nov) is a novel bone morphogenetic protein antagonist. (18083920)
2007
25
The role of the pain psychologist, trigger point injections, reflex sympathetic dystrophy. (17182517)
2006
26
The role of the retinal pigment epithelium in eye growth regulation and myopia: a review. (16079001)
2005
27
ESRD caused by nephrolithiasis: prevalence, mechanisms, and prevention. (15492945)
2004
28
Combination of genistein with ionizing radiation on androgen-independent prostate cancer cells. (15546018)
2004
29
CpG-A-induced monocyte IFN-gamma-inducible protein-10 production is regulated by plasmacytoid dendritic cell-derived IFN-alpha. (12682235)
2003
30
The Churg Strauss syndrome (allergic granulomatous angiitis): review and update. (14625818)
2003
31
Antiphospholipid syndrome. (14648227)
2003
32
Bi-directional coupling between dihydropyridine receptors and ryanodine receptors. (11861208)
2002
33
Use of statins and the subsequent development of deep vein thrombosis. (11386889)
2001
34
SOCS proteins: negative regulators of cytokine signaling. (11553846)
2001
35
An alternative open reading frame of the human macrophage colony-stimulating factor gene is independently translated and codes for an antigenic peptide of 14 amino acids recognized by tumor-infiltrating CD8 T lymphocytes. (11369790)
2001
36
Allograft inflammatory factor-1 defines a distinct subset of infiltrating macrophages/microglial cells in rat and human gliomas. (11078219)
2000
37
Genetic variability in the regulatory region of presenilin 1 associated with risk for Alzheimer's disease and variable expression. (10655540)
2000
38
Altered brain metabolism in the C57BL/Wld mouse strain detected by magnetic resonance spectroscopy: association with delayed Wallerian degeneration? (10500267)
1999
39
Tumor necrosis factor alpha as a uremic toxin: correlation with neuropathy, left ventricular hypertrophy, anemia, and hypertriglyceridemia in peritoneal dialysis patients. (10682077)
1999
40
A new factor derived from 1321N1 human astrocytoma cells causes differentiation of PC-12 cells mediated through mitogen-activated protein kinase cascade. (9739111)
1998
41
Salmonellosis associated with S typhimurium DT104 in the USA. (9023911)
1997
42
Adenocarcinoma in females detected in serous effusions. Cytomorphologic aspects and immunocytochemical reactivity to cytokeratins 7 and 20. (9250286)
1997
43
Modulation by angiotensin II of endothelial cell control of DNA synthesis in human mesangial cells. (9069452)
1997
44
A new locus for hemiplegic migraine maps to chromosome 1q31. (9371899)
1997
45
Cervical squamous cell carcinoma and its precursor lesions: cytodiagnostic criteria and pitfalls. (9390926)
1996
46
A case of advanced male breast cancer successfully treated by 5-fluorouracil, epirubicin and cyclophosphamide chemotherapy combined with tamoxifen. (8534185)
1995
47
Acquired von Willebrand's syndrome in association with a lupus-like anticoagulant corrected by intravenous immunoglobulin. (8172182)
1994
48
Suicide and patients with neurologic diseases. Methodologic problems. (1449409)
1992
49
Landau-Kleffner syndrome--epileptic aphasia in children--possible role of toxoplasma gondii infection. (2479399)
1988-1989
50
The Black Death. New insights into 18th century attitudes toward Bubonic Plague. (4876738)
1968

Variations for Lepromatous Leprosy

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Expression for genes affiliated with Lepromatous Leprosy

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Search GEO for disease gene expression data for Lepromatous Leprosy.

Pathways for genes affiliated with Lepromatous Leprosy

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Pathways related to Lepromatous Leprosy according to GeneCards Suite gene sharing:

(show all 49)
idSuper pathwaysScoreTop Affiliating Genes
19.9IFNG, IL2
29.5IFNG, TLR2, TNF
3
Show member pathways
9.4IFNG, IL2, TNF
49.4IFNG, IL2, TNF
5
Show member pathways
9.3IFNG, IFNGR1, TNF
69.3IFNG, IFNGR1, TNF
79.2IL10, IL12B, TNF
89.1IFNG, IL10, TLR2, TNF
99.1IFNG, IL10, IL2, TNF
10
Show member pathways
9.1IFNG, IL10, IL2, TNF
119.1HSPD1, IL10, TNF
129.0IFNG, IL2, IL4
139.0IFNG, IL2, IL4
149.0IFNG, IFNGR1, TLR2, TNF
159.0IFNG, IL12B, TLR2, TNF
168.9IFNG, IL10, IL12B, TNF
17
Show member pathways
8.8IFNG, IL12B, IL12RB1, IL12RB2
18
Show member pathways
8.7IL12B, IL12RB1, IL12RB2, IL2
198.7IFNG, IL10, IL2, IL4
208.6HSPD1, IL12B, TLR2, TNF
21
Show member pathways
8.6IFNG, IL2, IL4, TNF
228.6IFNG, IL2, IL4, TNF
238.6IL10, IL4, TLR2, TNF
248.6IFNG, IL10, IL12B, TLR2, TNF
258.3IFNG, IL10, IL12RB2, IL2, IL4
268.3IFNG, IL10, IL2, IL4, TNF
27
Show member pathways
8.3IFNG, IL10, IL2, IL4, TNF
28
Show member pathways
8.2IFNG, IFNGR1, IL4, TLR2, TNF
29
Show member pathways
8.2IFNG, IFNGR1, IL2, IL4, TNF
30
Show member pathways
8.1IFNG, IL10, IL12B, IL12RB1, IL2, TNF
31
Show member pathways
8.0IFNG, IL12B, IL12RB1, IL4, TLR2
32
Show member pathways
7.9IFNG, IFNGR1, IL2, IL4, TLR2, TNF
33
Show member pathways
7.8IFNG, IFNGR1, IL10, IL12B, IL2, TLR2
347.8IFNG, IL10, IL12B, IL2, IL4, TNF
35
Show member pathways
7.8IFNG, IL10, IL12B, IL2, IL4, TNF
367.6IFNG, IFNGR1, IL10, IL12B, IL12RB1, IL12RB2
37
Show member pathways
7.6IFNG, IL12B, IL12RB1, IL12RB2, IL2, IL4
387.5HSPD1, IFNG, IFNGR1, IL10, IL12B, TLR2
397.4IFNG, IL10, IL12RB1, IL12RB2, IL2, IL4
40
Show member pathways
7.4IFNG, IFNGR1, IL12B, IL2, IL4, TLR2
41
Show member pathways
7.3IFNG, IFNGR1, IL10, IL12B, IL4, TLR2
42
Show member pathways
7.3IFNG, IFNGR1, IL12B, IL12RB1, IL12RB2, IL2
43
Show member pathways
7.2IL10, IL12B, IL12RB1, IL12RB2, IL2, IL4
44
Show member pathways
6.9IFNG, IFNGR1, IL10, IL12B, IL12RB1, IL12RB2
45
Show member pathways
6.9IL10, IL12B, IL12RB1, IL12RB2, IL2, IL4
46
Show member pathways
6.8IFNG, IFNGR1, IL10, IL12B, IL12RB1, IL12RB2
47
Show member pathways
6.4IFNG, IFNGR1, IL10, IL12B, IL12RB1, IL12RB2
48
Show member pathways
6.4IFNG, IFNGR1, IL10, IL12B, IL12RB1, IL12RB2
49
Show member pathways
5.5HSPD1, IFNG, IFNGR1, IL10, IL12B, IL12RB1

GO Terms for genes affiliated with Lepromatous Leprosy

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Biological processes related to Lepromatous Leprosy according to GeneCards Suite gene sharing:

(show all 49)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of tumor necrosis factor productionGO:003276010.5IFNG, TLR2
2positive regulation of chemokine productionGO:003272210.5TLR2, TNF
3positive regulation of calcidiol 1-monooxygenase activityGO:006055910.5IFNG, TNF
4positive regulation of membrane protein ectodomain proteolysisGO:005104410.5IFNG, TNF
5receptor biosynthetic processGO:003280010.4IL10, TNF
6negative regulation of cytokine secretion involved in immune responseGO:000274010.4IL10, TNF
7positive regulation of tissue remodelingGO:003410510.4IL12B, IL2
8negative regulation of interleukin-17 productionGO:003270010.3IFNG, IL12B
9positive regulation of interleukin-17 productionGO:003274010.3IL12B, IL2
10protein import into nucleus, translocationGO:000006010.3IFNG, TNF
11negative regulation of interleukin-6 productionGO:003271510.3IL10, TNF
12positive regulation of smooth muscle cell apoptotic processGO:003439310.3IFNG, IL12B
13natural killer cell activationGO:003010110.2IL12B, IL2
14positive regulation of T-helper 17 cell lineage commitmentGO:200033010.2IL12B, IL12RB1
15positive regulation of T-helper 17 type immune responseGO:200031810.2IL12B, IL12RB1
16positive regulation of memory T cell differentiationGO:004338210.1IL12B, IL12RB1
17B cell proliferationGO:004210010.1HSPD1, IL10
18positive regulation of T cell mediated cytotoxicityGO:000191610.1IL12B, IL12RB1
19positive regulation of T-helper 1 type immune responseGO:000282710.1IL12B, IL12RB1
20positive regulation of T cell differentiationGO:004558210.0IL2, IL4
21extrinsic apoptotic signaling pathway in absence of ligandGO:009719210.0IL2, IL4
22positive regulation of mononuclear cell migrationGO:00716779.9IL4, TNF
23positive regulation of B cell proliferationGO:00308909.9IL2, IL4
24type 2 immune responseGO:00420929.9IL10, IL4
25negative regulation of endothelial cell apoptotic processGO:20003529.8IL10, IL4
26negative regulation of nitric oxide biosynthetic processGO:00450199.8IL10, IL4
27cell surface receptor signaling pathwayGO:00071669.7IFNG, IL12RB2, TNF
28positive regulation of cell adhesionGO:00457859.7IFNG, IL12B, TNF
29positive regulation of interleukin-10 productionGO:00327339.7IL12B, IL4
30positive regulation of osteoclast differentiationGO:00456729.6IFNG, IL12B, TNF
31positive regulation of chemokine biosynthetic processGO:00450809.6IFNG, IL4, TNF
32positive regulation of inflammatory responseGO:00507299.6IL12B, IL2, TLR2
33positive regulation of isotype switching to IgG isotypesGO:00483049.5IFNG, IL2, IL4
34negative regulation of growth of symbiont in hostGO:00441309.5IFNG, IL10, IL12B, TNF
35positive regulation of MHC class II biosynthetic processGO:00453489.4IFNG, IL10, IL4
36B cell activationGO:00421139.4HSPD1, IL4
37positive regulation of tyrosine phosphorylation of Stat5 proteinGO:00425239.4IL12B, IL2, IL4
38positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.4IL10, IL4, TNF
39positive regulation of interleukin-12 productionGO:00327359.4HSPD1, IFNG, IL12B, TLR2
40defense response to bacteriumGO:00427429.3IFNG, IL10, TNF
41cellular response to lipopolysaccharideGO:00712229.2IFNG, IL12B, TNF
42positive regulation of protein phosphorylationGO:00019349.1IL2, IL4, TNF
43defense response to protozoanGO:00428329.1IFNG, IL10, IL12B, IL4
44positive regulation of T cell proliferationGO:00421029.1IFNG, IL12B, IL2, IL4
45positive regulation of transcription, DNA-templatedGO:00458939.0IFNG, IL10, IL4, TNF
46positive regulation of interferon-gamma productionGO:00327298.8IL12B, IL12RB1, IL12RB2, IL2, TNF
47negative regulation of apoptotic processGO:00430668.5HSPD1, IL10, IL2, IL4
48positive regulation of transcription from RNA polymerase II promoterGO:00459448.3IFNG, IL10, IL2, IL4, TNF
49immune responseGO:00069558.1IFNG, IL10, IL2, IL4, TLR2, TNF

Sources for Lepromatous Leprosy

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet