MCID: LPR001
MIFTS: 62

Lepromatous Leprosy malady

Infectious diseases category

Summaries for Lepromatous Leprosy

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A leprosy that results in early cutaneous lesions which consist of pale macules that are small, diffuse, and symmetric. this form of leprosy is characterized by hypoesthesia over extensor surfaces of the distal extremities, alopecia affecting lateral aspects of the eyebrows, saddle-nose deformity and oral lepromas.

MalaCards: Lepromatous Leprosy, also known as leprosy, lepromatous, is related to leprosy and tuberculoid leprosy. An important gene associated with Lepromatous Leprosy is CD2 (CD2 molecule), and among its related pathways are Cytokines and Inflammatory Response and Th17 Differentiation. The drugs clofazimine and dapsone and the compounds pge2 and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and monocytes, and related mouse phenotypes are respiratory system and renal/urinary system.

Wikipedia:63 Lepromatous leprosy is a skin condition consisting of pale macules. more...

Aliases & Classifications for Lepromatous Leprosy

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

lepromatous leprosy 8
leprosy, lepromatous 60
leprosy lepromatous 44
type l leprosy 8


External Ids:

Disease Ontology8 DOID:10887
MeSH34 D015440
SNOMED-CT56 21560005
ICD9CM27 030.0
ICD1025 A30.5

Related Diseases for Lepromatous Leprosy

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17GeneCards, 18GeneDecks
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Diseases related to Lepromatous Leprosy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 254)
idRelated DiseaseScoreTop Affiliating Genes
1leprosy32.2IL2, TLR2
2tuberculoid leprosy31.1IL10, IL2RA, IFNG
3tuberculosis30.7IL2, IL4, IL12RB1, IL12B, IL18, IL10
4hepatitis30.6F2, IL18, TLR2
5tetanus30.6IL2, IL4, IL10, IL2RA, MBP, IFNG
6sarcoidosis30.6IL2, IL12RB1, IL1RN, IL12B, IL18, IL12RB2
7lupus erythematosus30.5F2, IL18
8leishmaniasis30.5IL4, IL10, IFNGR1, IFNG
9pulmonary tuberculosis30.5IL2, IL4, IL12RB1, IL12B, IL18, IL10
10glomerulonephritis30.4IL1RN, ITGB2, ICAM1
11systemic lupus erythematosus30.3F2, IL2, IL4, IL12RB1, IL1RN, IL12B
12anaplastic large cell lymphoma30.1IL2RA
13alopecia30.1VDR
14mastitis30.1TLR2
15neuropathy30.1MBP
16rhinitis30.1IL4, ICAM1
17periapical granuloma30.1IL4, IL2RA
18myeloid leukemia30.1VDR, ITGB2
19cutaneous leishmaniasis30.1IL10, IFNG
20mycosis fungoides30.1IL2, IL2RA, ITGB2
21myositis30.1IL1RN, ICAM1
22vasculitis30.1F2, ITGB2, ICAM1
23myasthenia gravis30.1IL2, IL4, IL10, MBP, IFNG
24hepatitis b30.1F2, IL12B, IL18, IL10, IL2RA, IFNG
25arthritis30.1IL4, IL1RN, IL18, IL10, VDR, ITGB2
26leukemia30.1IL2, IL4, IL12B, IL2RA, CD2, VDR
27borderline leprosy10.9
28molluscum contagiosum10.4
29chromoblastomycosis10.3
30mononeuritis multiplex10.3
31multicentric reticulohistiocytosis10.3
32sporotrichosis10.3
33vitiligo10.3
34mononeuritis10.3
35syphilis10.3
36neurofibromatosis10.1
37indeterminate leprosy10.1
38bullous pemphigoid10.1
39pure red-cell aplasia10.1
40porphyria cutanea tarda10.1
41coccidioidomycosis10.1
42hypohidrosis10.1
43mucocutaneous leishmaniasis10.1
44macroglobulinemia10.1
45proliferative glomerulonephritis10.1
46immune-complex glomerulonephritis10.1
47atrophic rhinitis10.1
48chronic rhinitis10.1
49rhinosporidiosis10.1
50pemphigus10.1

Graphical network of the top 20 diseases related to Lepromatous Leprosy:



Diseases related to lepromatous leprosy

Clinical Features for Lepromatous Leprosy

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Drugs & Therapeutics for Lepromatous Leprosy

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Lepromatous Leprosy

Drug clinical trials:

Search ClinicalTrials for Lepromatous Leprosy

Search NIH Clinical Center for Lepromatous Leprosy

Search CenterWatch for Lepromatous Leprosy

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Lepromatous Leprosy

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Anatomical Context for Lepromatous Leprosy

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32MalaCards
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MalaCards organs/tissues related to Lepromatous Leprosy:

32
Skin, T cells, Monocytes, Testes, Bone, Retina, Endothelial, Myeloid, Heart, Bone marrow, Spleen, Eye, Lymph node, Kidney, Tongue, Liver, Colon

Animal Models for Lepromatous Leprosy or affiliated genes

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36MGI
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Publications for Lepromatous Leprosy

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50PubMed
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Articles related to Lepromatous Leprosy:

(show top 50)    (show all 529)
idTitleAuthorsYear
1
Pseudoepitheliomatous hyperplasia and transepidermal elimination in lepromatous leprosy: does T-cell plasticity play a role? (23134990)
2012
2
Case of diffuse lepromatous leprosy associated with "Mycobacterium lepromatosis". (22012006)
2011
3
Abnormalities in intracellular processing and expression of interferon-gamma receptor in adherent cells from lepromatous leprosy patients. (20039824)
2010
4
HTLV-1 associated myelopathy diagnosed during lepromatous leprosy reaction treatment: a case report. (20802953)
2010
5
SNP 668C (-44) alters a NF-kappaB1 putative binding site in non-coding strand of human beta-defensin 1 (DEFB1) and is associated with lepromatous leprosy. (19460328)
2009
6
The blind man and the paralytic boy of lesnovo: diagnosis of borderline lepromatous leprosy after 660 years? (19770447)
2009
7
Borderline lepromatous leprosy presenting as a single cutaneous plaque. (19326020)
2009
8
Induction of lepromin reactivity in cured lepromatous leprosy patients: impaired chemokine response dissociates protective immunity from delayed type hypersensitivity. (19703581)
2009
9
What is your diagnosis? Hansen Disease (Lepromatous leprosy/multibacillary disease). (19326688)
2009
10
Sarcoidosis mimics lepromatous leprosy: a case report. (17621750)
2007
11
Histopathological study of apparently normal oral mucosa in lepromatous leprosy. (16375230)
2005
12
Infection by Mycobacterium leprae of household contacts of lepromatous leprosy patients from a post-elimination leprosy region of Colombia. (16410954)
2005
13
Primary involvement of penile skin in lepromatous leprosy. (16465827)
2005
14
Lepromatous leprosy reversal reaction. (15620563)
2005
15
Concomitant infection with pulmonary tuberculosis and lepromatous leprosy. (12974444)
2003
16
AP-1 is present in nuclear extracts of lymphocytes from lepromatous leprosy patients. (12768929)
2002
17
Localized linear lesions in lepromatous leprosy. (11898466)
2001
18
Light and electron microscopic study of peripheral nerve damage in patients with lepromatous leprosy (LL) and borderline lepromatous leprosy (BL). (10824461)
2000
19
Lepromatous leprosy in a renal transplant recipient. (9455556)
1998
20
Erythema nodosum leprosum in subgroups of lepromatous leprosy. (9503874)
1997
21
Asymptomatic macular erythematous lesions. Lepromatous leprosy, macular stage. (9267252)
1997
22
Clinico-pathological conference. Lepromatous leprosy. (9175019)
1997
23
Abnormalities of the sympathetic skin response in lepromatous leprosy. (8808668)
1996
24
Alterations in serum lipids in lepromatous leprosy patients with and without ENL reactions and their relationship to acute phase proteins. (8690968)
1996
25
Case report: cutaneous lymphoma and borderline leprosy simulating lepromatous leprosy. (8684256)
1996
26
Chemotherapy of lepromatous leprosy: recent developments and prospects for the future. (7698121)
1994
27
Loss of viability of Mycobacterium leprae isolated from nasal secretions of lepromatous leprosy patients following daily rifampicin and DDS therapy. (8127217)
1993
28
In vitro tumor necrosis factor production by mononuclear cells from lepromatous leprosy patients and from patients with erythema nodosum leprosum. (8500267)
1993
29
Powerful bactericidal activities of clarithromycin and minocycline against Mycobacterium leprae in lepromatous leprosy. (8257487)
1993
30
Effect of recombinant interferon gamma administration on lesional monocytes/macrophages in lepromatous leprosy patients. (8396615)
1993
31
A clinical trial of minocycline in lepromatous leprosy. (1737148)
1992
32
Long-term follow up of lepromatous leprosy patients receiving intralesional recombinant gamma-interferon. (1602206)
1992
33
Vitiligo and lepromatous leprosy. (2030309)
1991
34
Quantitation of the soluble E-receptor of human T lymphocytes by rocket electrophoresis in the serum of patients with lepromatous and tuberculoid leprosy. (1820499)
1991
35
Tuberculoid relapse in lepromatous leprosy. (2280657)
1990
36
An unusual case of Hansen's disease (lepromatous leprosy) with circulating anticoagulant and macroglobulinemia. (2119410)
1990
37
Effect of treatment on immune responsiveness in lepromatous leprosy patients. (2215058)
1990
38
Serum mucoproteins and plasma fibrinogen levels in recurrent erythema nodosum leprosum (ENL) syndrome in lepromatous leprosy. (2262722)
1990
39
Hepatic ultrasonography in patients with lepromatous leprosy. (2086679)
1990
40
Evaluation of Mycobacterium leprae antigens in the serological monitoring of a clofazimine-based chemotherapeutic study of dapsone resistant lepromatous leprosy patients in Cebu, Philippines. (2657302)
1989
41
The reconstitution of cell-mediated immunity in the cutaneous lesions of lepromatous leprosy by recombinant interleukin 2. (2494293)
1989
42
Effect of deoxyfructoserotonin (DFS) on lepromatous leprosy. (2894551)
1988
43
Armadillo exposure among Mexican-born patients with lepromatous leprosy. (3680998)
1987
44
Bilateral ulnar nerve abscesses in lepromatous leprosy. (2821135)
1987
45
Genetically restricted suppressor T-cell clones derived from lepromatous leprosy lesions. (2942780)
1986
46
Evaluation of levamisole, an immunopotentiator, in the treatment of lepromatous leprosy. (3572102)
1986
47
Cellular immunity in lepromatous and tuberculoid leprosy. (2935494)
1985
48
Phosphatidylinositomannosides in lepromatous leprosy nodules. (6396226)
1984
49
Fatal proliferative glomerulonephritis in lepromatous leprosy. (604658)
1977
50
SECONDARY AMYLOIDOSIS IN LEPROMATOUS LEPROSY. POSSIBLE RELATIONSHIPS OF DIET AND ENVIRONMENT. (14283377)
1965

Genetic Variations for Lepromatous Leprosy

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Expression for genes affiliated with Lepromatous Leprosy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lepromatous Leprosy

Search GEO for disease gene expression data for Lepromatous Leprosy.

Pathways for genes affiliated with Lepromatous Leprosy

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Sources:
37NCBI BioSystems Database, 52R&D Systems, 29KEGG, 53Reactome, 51QIAGEN, 4Cell Signaling Technology, 12EMD Millipore
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Pathways related to Lepromatous Leprosy according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3IL12B
210.3IL12RB1
310.0IL18, TLR2
49.9IFNGR1, IFNGR2, IFNG
5
Hide members
9.9IFNG, IFNGR1, IFNGR2
69.8IL18, ITGB2, TLR2
79.7IFNG, IL2RA, IL2
8
Development Thrombopoetin signaling via JAK-STAT pathway
Hide members
9.7IL4, IFNG, IL1RN
99.7ICAM1, IFNG, IL2
109.7IFNG, IFNGR2, TLR2, IFNGR1
119.7ICAM1, IFNG, ITGB2
12
Hide members
9.7IL2, IL4, IL2RA
139.6IL18, IFNGR1, IFNG, IFNGR2
149.6TLR2, ITGB2, IL18, IL12B
159.6IL2RA, IL12RB1, IL12RB2, IL12B
169.5IFNGR1, IFNGR2, IFNG, ICAM1
17
Immune response IFN gamma signaling pathway
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9.5ICAM1, IFNGR1, IFNGR2, IFNG
189.5IFNG, IL2RA, IL18, IL2
199.5IFNG, IL2RA, IL4, IL2
20
Hide members
9.5IL4, IFNG, IL2RA, IL2
219.4IL4, IL10, IL2, IFNG
22
Hide members
9.4IL2RA, IL2, IL10, IFNG
239.4IL12B, IL18, IFNG, ITGB2, TLR2
249.4IL4, IFNG, IL2, ICAM1
25
Hide members
9.4IL12RB1, CD2, IL2RA, IL12RB2, IL12B
26
Immune response Bacterial infections in normal airways
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9.4IL1RN, TLR2, IFNG, IFNGR2, IFNGR1
27
Hide members
9.3IL2RA, IL18, IL1RN, IL2
289.3IL12B, ITGB2, IFNG, TLR2, IL10
299.3IL12B, IL2RA, IL12RB2, IL12RB1, IL2
309.3IL2RA, IL10, IL4, IL2
31
Hide members
9.2IL12B, IL12RB1, IL18, CD2, IL12RB2, ITGB2
32
Hide members
9.1IL12RB1, IFNGR2, IFNGR1, CD2, IL2RA, IL12RB2
339.1ICAM1, IFNG, IL10, IL18, IL12B
349.1ICAM1, MBP, IL2, IL4
359.0IFNG, IL4, IL2, IL12B, IL18, IL10
36
Hide members
8.9IL10, IL2, IFNG, IFNGR1, IL12B, IFNGR2
37
Hide members
8.8IL2, IL4, IL2RA, IFNG, TLR2, IFNGR1
38
Hide members
8.7IL12RB2, IL18, IL12B, IL12RB1, ITGB2, IFNGR2
39
Hide members
8.7IL4, ICAM1, IFNGR1, IFNG, IFNGR2, IL2
40
Development PDGF signaling via STATs and NF-kB
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8.6IL12RB1, IL12B, F2, IL18, IL10, IFNG
41
Hide members
8.6IL4, IL12B, IL18, IL12RB1, IL2RA, IL12RB2
42
Hide members
8.5F2, CD2, ITGB2, IL2RA, IL12RB2, IL12B
43
Hide members
8.4ICAM1, IFNGR1, IL18, IFNGR2, IFNG, IL1RN
44
Hide members
8.2IL12RB2, IL18, IL12B, IL12RB1, IL2, IFNGR1
458.2IFNGR2, IL12B, IFNG, IL18, IFNGR1, TLR2
468.1IL2, IL4, IL12RB1, IL12B, IL10, IL12RB2
47
Hide members
8.0TLR2, IFNGR2, IFNG, IFNGR1, ICAM1, IL2RA
48
Hide members
7.8IL18, TLR2, IL12RB1, IL10, IL2, IL12B
49
Hide members
7.7TLR2, IFNGR2, DEFB1, IL2, IL1RN, IL18
50
Hide members
7.4IL4, IL12RB1, IL12B, IL18, IL10, IL12RB2

Compounds for genes affiliated with Lepromatous Leprosy

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 2BitterDB, 24HMDB
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Compounds related to Lepromatous Leprosy according to GeneCards/GeneDecks:

(show top 50)    (show all 144)
idCompoundScoreTop Affiliating Genes
1pge24410.6IL2
2endotoxin4410.5ICAM1
3cycloheximide4410.4TLR2, IL18
4indomethacin44 59 28 1113.3MBP
5gm-csf44 2811.0IL10, IFNG, ICAM1
6amphotericin b449.9IL1RN
7dexamethasone44 49 28 1112.8TLR2, ITGB2, DEFB1, VDR
8prednisolone44 28 1111.8ITGB2, MBP, IL2RA
9alpha-galactosylceramide449.7IFNG, IL10, IL4, IL2
10imiquimod44 28 59 1112.6IL10, IFNG, IL12B, TLR2, IL18
11pentoxifylline44 1110.6IL4, IL1RN, IL12B, IL18, ITGB2
12poly(i-c)449.6IFNG, TLR2, IL12B, IL4, IL18
13ivig449.6IFNG, MBP, IL1RN, ITGB2
14gold sodium thiomalate449.6IL2RA, IFNG, IL1RN, IL2
15cyclophosphamide44 49 1111.5ITGB2, MBP, IL2RA, IL2
16tuberculin449.5IFNG, IL10, IL2RA, IL18
17lipoteichoic acid449.5IL1RN, IL12B, IL18, IL10, TLR2
18interferon gamma449.4IL10, ICAM1, IL4, IL2, IFNG
19mycophenolate mofetil44 49 1111.4IL2RA, IFNG, IL18, IL2, IL10
20natalizumab44 1110.4ICAM1, IL18, IL2RA, IFNG, IL10
21ribavirin44 49 1111.4IL4, IFNG, IL2, IL10, IL18
22glatiramer acetate44 1110.3IL4, IFNG, IL2, IL10, MBP
23tarc449.2IL4, IL10, ICAM1, IFNG, IL18
24il-12449.2IL2, IL10, IL4, IL12RB1, IL12B, IL18
25tacrolimus44 49 1111.2IL2, IL4, IL2RA, VDR, IFNG, TLR2
26thalidomide44 49 59 1112.2IL2, ITGB2, IL18, IL10, IL2RA, IFNG
27polyinosinic-polycytidylic acid449.2IL10, IFNG, IL18, IL12B, IL4, IL2
28infliximab44 49 1111.1IL10, IL4, IL1RN, IL18, IFNG, IL2RA
29vegf449.1IL18, IL1RN, TLR2, ITGB2, IL2RA, IL10
30ccl344 2810.1IL10, IL18, IFNG, TLR2, ICAM1
31allergens449.1IFNG, IL4, IL1RN, IL18, IL10
32ifn-alpha449.0IL18, IL2RA, IL10, IL2, IFNG
33chloroquine44 2 49 28 1113.0IL4, IL1RN, IL18, IL10, IL2, IL2RA
34okt3448.9ICAM1, ITGB2, IL2, IL2RA, IL10, IL4
35herbimycin a44 599.9ICAM1, ITGB2, IFNG, IL2RA, IL4, IL2
36rantes448.9IL2, IL4, IL12B, IL2RA, ITGB2, TLR2
37con a448.9IL2, IL4, IFNG, CD2, IL2RA, IL18
38polymyxin b448.8IL4, IL1RN, IL10, DEFB1, ITGB2, IFNG
39vitamin d448.6VDR, IL1RN, TLR2, IL10, IL12B, IL2RA
40neopterin448.6IL4, IL1RN, IL18, IL10, IL2RA, ICAM1
41ionomycin448.5IL4, IL12RB1, IL10, IL2RA, CD2, ITGB2
42calcitriol44 59 11 2411.4TLR2, IFNG, VDR, IL2RA, IL10, IL4
43simvastatin44 49 59 28 11 2413.3IL18, IL4, F2, IL1RN, IL10, ITGB2
44cyclosporin a44 28 5910.3VDR, IL2RA, ITGB2, MBP, ICAM1, IFNG
45il 10448.2TLR2, IFNG, VDR, IL2RA, IL10, IL18
46histamine44 28 2410.1IFNG, TLR2, ICAM1, ITGB2, IL2RA, IL10
47thymidine44 249.0IL2RA, IFNG, IL4, VDR, CD2, IL2
48sb 20358044 599.0ICAM1, IFNG, TLR2, IL12B, ITGB2, VDR
49retinoic acid44 248.8TLR2, ICAM1, IL1RN, IFNGR2, VDR, DEFB1
50tyrosine447.3IL18, IL1RN, ITGB2, IFNGR1, ICAM1, MBP

GO Terms for genes affiliated with Lepromatous Leprosy

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16Gene Ontology
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Cellular components related to Lepromatous Leprosy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.4TLR2, IFNG, ICAM1, CD2, IL2RA, IL12RB2
2extracellular spaceGO:0056157.6F2, IL2, IL4, IL1RN, IFNG, IL12B
3plasma membraneGO:0058867.5F2, TLR2, IFNGR2, IFNGR1, ICAM1, MBP

Biological processes related to Lepromatous Leprosy according to GeneCards/GeneDecks:

(show all 46)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of T-helper 17 cell lineage commitmentGO:200033010.4IL12RB1, IL12B
2interferon-gamma biosynthetic processGO:04209510.4IL12B, IL18
3positive regulation of memory T cell differentiationGO:04338210.4IL12B, IL12RB1
4positive regulation of NK T cell proliferationGO:05114210.4IL18, IL12B
5negative regulation of interleukin-17 productionGO:03270010.3TLR2, IFNG, IL12B
6positive regulation of smooth muscle cell apoptotic processGO:03439310.3IFNG, IL12B
7positive regulation of T-helper 17 type immune responseGO:200031810.3IL12B, IL12RB1
8positive regulation of granulocyte macrophage colony-stimulating factor productionGO:03272510.3IL12B, IL18
9positive regulation of interleukin-12 productionGO:03273510.3TLR2, IFNG, IL12B
10regulation of T cell homeostatic proliferationGO:04601310.3IL2, IL2RA
11positive regulation of natural killer cell proliferationGO:03281910.3IL18, IL12B
12regulation of interferon-gamma-mediated signaling pathwayGO:06033410.2IFNGR1, IFNG, IFNGR2
13positive regulation of T-helper 1 type immune responseGO:00282710.2IL12B, IL12RB1
14defense response to protozoanGO:04283210.2IL4, IFNG, IL12B
15positive regulation of NF-kappaB import into nucleusGO:04234610.2IL18, TLR2, IL12B
16positive regulation of tissue remodelingGO:03410510.2IL2, IL12B, IL18
17positive regulation of interleukin-17 productionGO:03274010.2IL2, IL12B, IL18
18cellular response to interferon-gammaGO:07134610.2IL18, IL12B, IL12RB1
19positive regulation of chemokine biosynthetic processGO:04508010.2IL4, IFNG
20positive regulation of isotype switching to IgG isotypesGO:04830410.2IL4, IL2, IFNG
21regulation of isotype switchingGO:04519110.2IL10, IL4
22positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.2IL12B, IL4, IL2
23positive regulation of T cell proliferationGO:04210210.1IL12B, IL4, IFNG
24positive regulation of MHC class II biosynthetic processGO:04534810.1IL4, IFNG, IL10
25positive regulation of tumor necrosis factor productionGO:03276010.1TLR2, IL18, IL12B, IFNG
26natural killer cell activationGO:03010110.1CD2, IL12B, IL2, IL18
27positive regulation of nitric oxide biosynthetic processGO:04542910.1IFNG, ICAM1, TLR2
28T-helper 1 type immune responseGO:04208810.0IL12B, IL18
29type 2 immune responseGO:04209210.0IL10, IL18, IL4
30negative regulation of growth of symbiont in hostGO:04413010.0TLR2, IL10, IFNG, IL12B
31positive regulation of inflammatory responseGO:05072910.0IL18, TLR2, IL2, IL12B
32negative regulation of interleukin-12 productionGO:0326959.9IL10, TLR2
33negative regulation of nitric oxide biosynthetic processGO:0450199.9IL10, IL4
34interferon-gamma-mediated signaling pathwayGO:0603339.9ICAM1, IFNGR2, IFNGR1, IFNG
35positive regulation of T cell differentiationGO:0455829.8IL2RA, IL4
36positive regulation of interferon-gamma productionGO:0327299.8IL2, IL12RB1, IL12RB2, IL18, IL12B
37cellular response to lipopolysaccharideGO:0712229.8IL12B, IFNG, IL10, ICAM1
38leukocyte migrationGO:0509009.6ITGB2, F2, CD2, ICAM1
39cell-cell signalingGO:0072679.5IL10, IL18, IL2, ITGB2
40cytokine-mediated signaling pathwayGO:0192219.5IFNGR2, IFNGR1, IL12RB1, IL12RB2, ICAM1, IFNG
41positive regulation of activated T cell proliferationGO:0421049.4IL2, IL2RA, IL12RB1, IL18, IL12B, IL4
42cell surface receptor signaling pathwayGO:0071669.4IL2RA, F2, IL12RB2, IFNGR2, CD2, IFNG
43response to drugGO:0424939.3IFNG, IL4, ICAM1, IL10, IL1RN
44regulation of immune responseGO:0507769.3ICAM1, ITGB2, IL4
45positive regulation of transcription from RNA polymerase II promoterGO:0459449.1VDR, TLR2, IFNG, IL10, IL4, IL2
46immune responseGO:0069558.6TLR2, MBP, DEFB1, IL18, IL1RN, IL4

Molecular functions related to Lepromatous Leprosy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interferon-gamma receptor activityGO:00490610.0IFNGR1, IFNGR2
2cytokine receptor activityGO:0048969.9IL12RB2, IL12B, IL12RB1
3interleukin-12 receptor bindingGO:0051439.8IL12RB1, IL12B
4receptor activityGO:0048729.5CD2, ITGB2, ICAM1, TLR2
5cytokine activityGO:0051259.1IL2, IL4, IL12B, IL18, IL10, IFNG
6growth factor activityGO:0080839.1IL10, IL12B, IL4, IL2, F2

Products for genes affiliated with Lepromatous Leprosy

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  • Antibodies
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Sources for Lepromatous Leprosy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet