MCID: LPR001
MIFTS: 49

Lepromatous Leprosy malady

Category: Infectious diseases

Aliases & Classifications for Lepromatous Leprosy

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Aliases & Descriptions for Lepromatous Leprosy:

Name: Lepromatous Leprosy 11 13
Leprosy, Lepromatous 38 67
 
Leprosy Lepromatous 49
Type L Leprosy 11

Classifications:



External Ids:

Disease Ontology11 DOID:10887
ICD1029 A30.5
SNOMED-CT61 21560005
ICD9CM31 030.0
MeSH38 D015440

Summaries for Lepromatous Leprosy

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Disease Ontology:11 A leprosy that results in early cutaneous lesions which consist of pale macules that are small, diffuse, and symmetric. This form of leprosy is characterized by hypoesthesia over extensor surfaces of the distal extremities, alopecia affecting lateral aspects of the eyebrows, saddle-nose deformity and oral lepromas.

MalaCards based summary: Lepromatous Leprosy, also known as leprosy, lepromatous, is related to paralytic lagophthalmos and hemophagocytic lymphohistiocytosis. An important gene associated with Lepromatous Leprosy is TLR2 (Toll Like Receptor 2), and among its related pathways are RXR and RAR heterodimerization with other nuclear receptor and MSP-RON Signaling. The drugs dapsone and clofazimine have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and monocytes, and related mouse phenotypes are muscle and liver/biliary system.

Wikipedia:70 Lepromatous leprosy is a skin condition consisting of pale macules. more...

Related Diseases for Lepromatous Leprosy

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Diseases related to Lepromatous Leprosy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 297)
idRelated DiseaseScoreTop Affiliating Genes
1paralytic lagophthalmos30.4IL10, TNF
2hemophagocytic lymphohistiocytosis30.1IFNG, IL10, TNF
3hepatitis b30.0IFNG, IL10, TNF
4macroglobulinemia30.0CD2, ICAM1
5alopecia29.8ICAM1, IL10, TNF
6systemic lupus erythematosus29.3ICAM1, IFNG, IL10, IL2, TNF
7leprosy11.5
812p12.1 microdeletion syndrome10.7IL10, TNF
9piepkorn karp hickok syndrome10.6IL10, TNF
10panner disease10.6IFNG, TNF
11baetz-greenwalt syndrome10.6IFNG, TNF
126q terminal deletion syndrome10.6IL10, TNF
13antigen-peptide-transporter 2 deficiency10.6TLR2, TNF
14nevus mucinosis10.6IL10, TLR2
15autoimmune pancreatitis10.6IFNG, TNF
163-alpha hydroxyacyl-coa dehydrogenase deficiency10.6TLR2, TNF
17linitis plastica10.6IL2, TNF
18basidiobolomycosis10.6IL10, TNF
19primary systemic mycosis10.6IFNG, TNF
20eye accommodation disease10.6IFNG, IL10
21t-cell lymphoma 1a10.5TLR2, TNF
22gonococcal synovitis10.5IFNG, TNF
23fallopian tube endometriosis10.5IL10, TNF
24thelaziasis10.5IFNG, IL10
25maligant granulosa cell tumor of ovary10.5IL2, TNF
26neurotic excoriation10.5IL10, TNF
27bulbospinal polio10.5IFNG, IL2
28trichosporonosis10.5TLR2, TNF
29pasteurellosis10.5IFNG, TNF
30brucella abortus brucellosis10.5IL2, TNF
31lymphocytic colitis10.5IFNG, TNF
32anthracosilicosis10.5IFNG, IL2
33chronic hiccups10.5IFNG, IL10
34buruli ulcer10.5IFNG, IL10
35potato nose10.5TLR2, TNF
36thomsen and becker disease10.5IFNG, IL2
37panuveitis10.5IL10, TNF
38pediatric t-cell leukemia10.5IL10, IL2
39steatorrhea10.5IFNG, TNF
40peripheral t-cell lymphoma10.5IL10, TNF
41mycobacterium fortuitum10.5TLR2, TNF
42nelson syndrome10.5IFNG, IL10
43stampe sorensen syndrome10.5IFNG, TNF
44skin disease10.4IL12RB2, TNF
45herpangina10.4IFNG, IL10
46orbit alveolar rhabdomyosarcoma10.4IFNG, IL10
47toxocariasis10.4IFNG, TLR2
48pernicious anemia10.4IL10, TLR2
49burns10.4IL10, TNF
50rhizomelic pseudopolyarthritis10.4ICAM1, TNF

Graphical network of the top 20 diseases related to Lepromatous Leprosy:



Diseases related to lepromatous leprosy

Symptoms for Lepromatous Leprosy

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Drugs & Therapeutics for Lepromatous Leprosy

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Drugs for Lepromatous Leprosy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Clofazimineapproved, investigationalPhase 4232030-63-92794
Synonyms:
(3Z)-N,5-bis(4-chlorophenyl)-3-[(1-methylethyl)imino]-3,5-dihydrophenazin-2-amine
2030-63-9
3-(p-Chloranilino)-10-(p-chlorophenyl)-2,10-dihydro-2-(isopropylimino)-phenazine
3-(p-Chloranilino)-10-(p-chlorophenyl)-2,10-dihydro-2-(isopropylimino)phenazine
3-(p-Chloranilino)-10-(p-chlorphenyl)-2,10-dihydro-2-(isopropylimino)-phenazin
3-(p-Chloranilino)-10-(p-chlorphenyl)-2,10-dihydro-2-(isopropylimino)-phenazin [German]
3-(p-Chloroanilino)-10-(p-chlorophenyl)-2,10-dihydro-2-(isopropylimino)phenazine
4-25-00-03033 (Beilstein Handbook Reference)
AC1L1EHE
B 663
B 663 (Pharmaceutical)
B 663 (VAN)
B 663, pharmaceutical
B-663
B. 663
B663
BIDD:PXR0147
BPBio1_000585
BRN 0060420
BSPBio_000531
C06915
C27H22Cl2N4
C8895_SIGMA
CAS-2030-63-9
CFZ
CHEBI:3749
CHEBI:730395
CHEMBL1083384
CHEMBL1292
CID2794
CPD000058704
Chlofazimine
Clofazimin
Clofazimina
Clofazimina [INN-Spanish]
Clofazimine
Clofazimine (JAN/USP/INN)
Clofazimine [USAN:INN:BAN]
Clofaziminum
Clofaziminum [INN-Latin]
 
D00278
DB00845
EINECS 217-980-2
G 30320
G-30,320
G-30320
HMS1569K13
HMS2052B05
HMS2093J10
I06-1891
LS-103014
Lampren
Lamprene
Lamprene (TN)
Liposome-encapsulated clofazimine
MLS000028617
MLS001424318
N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-(1-methylethyl)imino)-2-phenazinamine
N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-(isopropylimino)phenazin-2-amine
N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-[(1-methylethyl)imino]-2-phenazinamine
N,5-bis(4-chlorophenyl)-3-(propan-2-ylimino)-3,5-dihydrophenazin-2-amine
N,5-bis(4-chlorophenyl)-3-propan-2-yliminophenazin-2-amine
NCGC00016600-01
NCGC00016600-02
NCGC00179529-01
NSC 141046
NSC-141046
NSC141046
Prestwick0_000376
Prestwick1_000376
Prestwick2_000376
Prestwick3_000376
Prestwick_685
Riminophenazine
SAM001246878
SMP2_000339
SMR000058704
SPBio_002452
ST51014966
UNII-D959AE5USF
clofazimine
2Anti-Bacterial AgentsPhase 410884
3VitaminsPhase 45095
4Anti-Inflammatory AgentsPhase 410355
5Anti-Infective AgentsPhase 421402
6
Acetylcholineapproved77651-84-3187
Synonyms:
ACh
Acetyl choline ion
Acetylcholine Chloride
Acetylcholine cation
 
Acetylcholinium: acetyl-Choline
Choline acetate
Choline acetate (ester)
O-Acetylcholine
acetylcholine chloride
7
Nitroprussideapproved6115078-28-111963622
Synonyms:
13755-38-9 (di-hydrochloride salt, diH20)
14402-89-2 (di-hydrochloride salt)
15078-28-1
C07269
CHEMBL74115
CID11953891
Disodium nitroprusside dihydrate
LS-187044
Nipride
 
Nitroferricyanide
Nitropress
Nitroprusside
Pentacyanidonitrosylferrate(2-)
Sodium Nitroprusside
Sodium nitroferricyanide dihydrate
Sodium nitroprusside dihydrate
Sodium nitroprusside extra pure
UNII-169D1260KM
[Fe(CN)5(NO)](2-)
nitroferricyanide
8
Nitric Oxideapproved59910102-43-9145068
Synonyms:
(.)NO
(NO)(.)
10102-43-9
14332-28-6
295566_ALDRICH
51005-20-0
51005-21-1
53851-19-7
90452-29-2
AC1L1ADQ
AC1L3QHF
AC1Q6QZ0
AR-1K7463
Bioxyde d'azote
Bioxyde d'azote [French]
C00533
CCRIS 4319
CHEMBL1200689
CHEMBL1234765
CID145068
CID945
D00074
D009569
DB00435
EDRF
EINECS 233-271-0
Endogenous Nitrate Vasodilator
Endothelium-Derived Nitric Oxide
HNO
HSDB 1246
INOmax
INOmax (TN)
LS-192158
LS-7547
MolPort-003-929-452
Mononitrogen monoxide
Monoxide, Mononitrogen
Monoxide, Nitrogen
Monoxido de nitrogeno
Monoxyde d'azote
NITRIC-OXIDE
NO
NO(.)
Nitrate Vasodilator, Endogenous
Nitric Oxide, Endothelium Derived
 
Nitric Oxide, Endothelium-Derived
Nitric oxide
Nitric oxide (JAN)
Nitric oxide 10% by volume or more
Nitric oxide trimer
Nitric oxide, compressed [UN1660] [Poison gas]
Nitric oxide, compressed [UN1660] [Poison gas]
Nitrogen monoxide
Nitrogen oxide
Nitrogen oxide (NO)
Nitrogen protoxide
Nitrosyl
Nitrosyl hydride
Nitrosyl hydride ((NO)H)
Nitrosyl radical
Nitroxide radical
Nitroxyl
OHM 11771
Oxide, Nitric
Oxido de nitrogeno(ii)
Oxido nitrico
Oxyde azotique
Oxyde nitrique
Oxyde nitrique [French]
RCRA waste no. P076
Stickmonoxyd
Stickmonoxyd [German]
Stickstoff(II)-oxid
Stickstoff(ii)-oxid
Stickstoffmonoxid
UN 1660
UN1660
UNII-31C4KY9ESH
Vasodilator, Endogenous Nitrate
[NO]
endothelium-derived relaxing factor
monoxido de nitrogeno
monoxyde d'azote
nitric oxide
nitrogen monooxide
nitrogen monoxide
nitrosyl
oxido de nitrogeno(II)
oxido nitrico
oxidonitrogen(.)
oxoazanyl
oxyde azotique
9Vasodilator Agents3438
10Pharmaceutical Solutions7793
11Antihypertensive Agents4095
12Cholinergic Agents3846
13Neurotransmitter Agents17734
14Nitric Oxide Donors112

Interventional clinical trials:

idNameStatusNCT IDPhase
1Effect of Additional Clofazimine on Erythema Nodosum Leprosum (ENL) Reactions in LeprosyCompletedNCT01290744Phase 4
2Microcirculatory Impairment in Patients With LeprosyCompletedNCT02085317
3Treatment Protocol for Clofazamine in the Long Term Treatment of LeprosyNo longer availableNCT00852345

Search NIH Clinical Center for Lepromatous Leprosy

Inferred drug relations via UMLS67/NDF-RT45:


Cochrane evidence based reviews: leprosy, lepromatous

Genetic Tests for Lepromatous Leprosy

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Anatomical Context for Lepromatous Leprosy

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MalaCards organs/tissues related to Lepromatous Leprosy:

35
Skin, T cells, Monocytes, Bone, Testes, Lymph node, Myeloid

Animal Models for Lepromatous Leprosy or affiliated genes

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MGI Mouse Phenotypes related to Lepromatous Leprosy:

40 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.9ICAM1, IFNG, IL10, TLR2, TNF, VDR
2MP:00053708.6IFNG, IFNGR1, IL10, IL12RB2, IL2, TLR2
3MP:00107718.3ICAM1, IFNG, IFNGR1, IL10, TLR2, TNF
4MP:00020068.0ICAM1, IFNG, IFNGR1, IL10, IL12RB2, IL2
5MP:00053848.0ICAM1, IFNG, IFNGR1, IL10, IL2, TLR2
6MP:00053857.6ICAM1, IFNG, IFNGR1, IL10, IL12RB2, IL2
7MP:00053817.6ICAM1, IFNG, IFNGR1, IL10, IL12RB2, IL2
8MP:00053797.6ICAM1, IFNG, IFNGR1, IL10, IL12RB2, IL2
9MP:00053976.8ICAM1, IFNG, IFNGR1, IL10, IL12RB1, IL12RB2
10MP:00053766.8ICAM1, IFNG, IFNGR1, IL10, IL12RB1, IL12RB2
11MP:00053876.8ICAM1, IFNG, IFNGR1, IL10, IL12RB1, IL12RB2

Publications for Lepromatous Leprosy

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Articles related to Lepromatous Leprosy:

(show top 50)    (show all 547)
idTitleAuthorsYear
1
Dapsone hypersensitivity syndrome in a lepromatous leprosy patient--A Case Report. (26502691)
2015
2
Activation and cytokine profile of monocyte derived dendritic cells in leprosy: in vitro stimulation by sonicated Mycobacterium leprae induces decreased level of IL-12p70 in lepromatous leprosy. (26222022)
2015
3
Disseminated cutaneous BCG infection following BCG immunotherapy in patients with lepromatous leprosy. (26502690)
2015
4
Oral manifestation of lepromatous leprosy: diagnosis and management. (24848267)
2014
5
Lepromatous leprosy and perianal tuberculosis: a case report and literature review. (25180030)
2014
6
Lepromatous leprosy treated with combined chemotherapy and immunotherapy (injection BCG): three case reports. (23675902)
2014
7
Fulminant hepatic failure in a 15 year old boy with borderline lepromatous leprosy and type 2 reaction. (24974443)
2014
8
Borderline lepromatous leprosy with type 1 (downgrading) reaction. (24252148)
2013
9
Deck chair sign in lepromatous leprosy. (24428120)
2013
10
Serum metabolomics reveals higher levels of polyunsaturated fatty acids in lepromatous leprosy: potential markers for susceptibility and pathogenesis. (21909445)
2011
11
Lepromatous leprosy: a commonly misdiagnosed disease. (21170484)
2010
12
SNP 668C (-44) alters a NF-kappaB1 putative binding site in non-coding strand of human beta-defensin 1 (DEFB1) and is associated with lepromatous leprosy. (19460328)
2009
13
Lepromatous leprosy with erythema nodosum leprosum as immune reconstitution inflammatory syndrome in an HIV-1 infected patient after initiation of antiretroviral therapy. (22132023)
2009
14
Anti-phospholipid syndrome preceding a diagnosis of lepromatous leprosy. (19723478)
2009
15
Lepromatous leprosy of histoid type. (17377360)
2007
16
Lepromatous leprosy. (17290718)
2007
17
Lichen scrofulosorum in a patient with lepromatous leprosy after BCG immunotherapy. (16038252)
2005
18
Histopathological study of apparently normal oral mucosa in lepromatous leprosy. (16375230)
2005
19
Infection by Mycobacterium leprae of household contacts of lepromatous leprosy patients from a post-elimination leprosy region of Colombia. (16410954)
2005
20
Lepromatous leprosy with extensive unusual ulcerations and cachexia. Is it the first case of Lucio's phenomenon from Iran? (15217312)
2004
21
Intra-abdominal, crystal-storing histiocytosis due to clofazimine in a patient with lepromatous leprosy and concurrent carcinoma of the colon. (15282969)
2004
22
An in vitro model for the lepromatous leprosy granuloma: fate of Mycobacterium leprae from target macrophages after interaction with normal and activated effector macrophages. (15187161)
2004
23
Near-nerve potential in lepromatous leprosy. (14506718)
2003
24
Lepromatous leprosy and reversal reaction in a Micronesian immigrant. (14636206)
2003
25
Missense mutations of the interleukin-12 receptor beta 1(IL12RB1) and interferon-gamma receptor 1 (IFNGR1) genes are not associated with susceptibility to lepromatous leprosy in Korea. (12743658)
2003
26
Anetoderma secondary to lepromatous leprosy. (11326598)
2001
27
Oral lesions in lepromatous leprosy. Presentation of a case and literature review. (11507569)
2000
28
Fine-needle aspiration cytology of lepromatous leprosy. (9715599)
1998
29
Abnormalities of the sympathetic skin response in lepromatous leprosy. (8808668)
1996
30
Localized borderline lepromatous leprosy. (8537706)
1995
31
Tongue involvement in lepromatous leprosy. (8425797)
1993
32
Loss of viability of Mycobacterium leprae isolated from nasal secretions of lepromatous leprosy patients following daily rifampicin and DDS therapy. (8127217)
1993
33
Tuberculoid relapse in lepromatous leprosy. (8341121)
1993
34
Comparative assessment of the leprosy antibody absorption test, Mycobacterium leprae extract enzyme-linked immunosorbent assay, and gelatin particle agglutination test for serodiagnosis of lepromatous leprosy. (8501238)
1993
35
High antibody levels to the mycobacterial fibronectin-binding antigen of 30-31 kD in tuberculosis and lepromatous leprosy. (1371953)
1992
36
A clinical trial of minocycline in lepromatous leprosy. (1737148)
1992
37
Vitiligo and lepromatous leprosy. (2030309)
1991
38
Transmission of viable Mycobacterium leprae by Aedes aegypti from lepromatous leprosy patients to the skin of mice through interrupted feeding. (2034021)
1991
39
Antibodies to Mycobacterium tuberculosis-specific epitopes in lepromatous leprosy. (1721012)
1991
40
Histoid lepromas of lepromatous leprosy. (2228377)
1990
41
Tuberculoid relapse in lepromatous leprosy. (2280657)
1990
42
Positive Mitsuda lepromin reactions in long-term treated lepromatous leprosy. (2280656)
1990
43
Mechanisms of Mycobacterium leprae-specific T-cell deficiency in lepromatous leprosy. (3147697)
1988
44
Facies leprosa: resorption of maxillary anterior alveolar bone and the anterior nasal spine in patients with lepromatous leprosy in Mali. (3373085)
1988
45
A comparative study of testicular involvement in lepromatous and borderline lepromatous leprosy. (3138377)
1988
46
The specificity of the immunodeficiency in lepromatous leprosy. (3553795)
1986
47
Lymphocyte transformation in lepromatous leprosy: a study of the influence of disease activity and symptom duration. (3738597)
1986
48
Lepromatous leprosy: study of some subpopulations of lymphocytes and their functional analysis. (2934039)
1985
49
An electron microscopic study of the small cutaneous vessels in lepromatous leprosy. (3889193)
1985
50
Mononeuritis multiplex in lepromatous leprosy. (5690422)
1968

Variations for Lepromatous Leprosy

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Expression for genes affiliated with Lepromatous Leprosy

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Search GEO for disease gene expression data for Lepromatous Leprosy.

Pathways for genes affiliated with Lepromatous Leprosy

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Pathways related to Lepromatous Leprosy according to GeneCards Suite gene sharing:

(show all 47)
idSuper pathwaysScoreTop Affiliating Genes
19.6TNF, VDR
29.5IFNG, TLR2, TNF
39.5IFNG, IL10, IL2
4
Show member pathways
9.5IFNG, IL2, TNF
5
Show member pathways
9.5IFNG, IL2, TNF
69.3ICAM1, IFNG, IL2
79.3IFNG, TNF, VDR
8
Show member pathways
9.2IFNG, IFNGR1, TNF
99.2IFNG, IL10, TLR2, TNF
10
Show member pathways
9.1IFNG, IL10, IL2, TNF
119.1IFNG, IL10, IL2, TNF
12
Show member pathways
9.1IFNG, IL10, IL2, TNF
139.1IFNG, IL10, IL2, TNF
14
Show member pathways
9.1IFNG, IL10, IL2, TNF
159.1IFNG, IL10, IL12RB2, IL2
16
Show member pathways
9.1IFNG, IL12RB1, TLR2
179.0ICAM1, IFNG, IFNGR1
189.0ICAM1, IFNG, TLR2, TNF
199.0CD2, IL10, IL2, TNF
209.0ICAM1, IFNG, IL2, TNF
219.0ICAM1, IFNG, IL2, TNF
229.0ICAM1, IL10, TLR2, TNF
23
Show member pathways
8.9IFNG, IL12RB1, IL12RB2
248.9ICAM1, IFNG, IL10, TNF
258.9IFNG, IFNGR1, TLR2, TNF
26
Show member pathways
8.9IFNG, IFNGR1, TLR2, TNF
278.9IFNG, IL10, IL2, TLR2, TNF
288.7CD2, IFNG, IL10, IL2, TNF
298.7ICAM1, IFNG, IL10, TLR2, TNF
30
Show member pathways
8.6IFNG, IL12RB1, IL12RB2, IL2
31
Show member pathways
8.6IFNG, IFNGR1, IL10, TLR2, TNF
32
Show member pathways
8.3ICAM1, IFNG, IFNGR1, IL2, TNF
33
Show member pathways
8.3IFNG, IL10, IL12RB1, IL2, TNF
34
Show member pathways
8.2IFNG, IFNGR1, IL10, IL2, TLR2, TNF
35
Show member pathways
8.1ICAM1, IFNG, IFNGR1, IL2, TLR2, TNF
368.0IFNG, IFNGR1, IL10, TLR2, TNF, VDR
37
Show member pathways
7.9CD2, ICAM1, IFNG, IFNGR1, IL10, IL2
387.9IFNG, IL10, IL12RB1, IL12RB2, IL2, TNF
39
Show member pathways
7.7CD2, IL10, IL12RB1, IL12RB2, IL2, TNF
407.7IFNG, IFNGR1, IL10, IL12RB1, IL12RB2, IL2
41
Show member pathways
7.5CD2, IL10, IL12RB1, IL12RB2, IL2, TLR2
42
Show member pathways
7.3IFNG, IFNGR1, IL10, IL12RB1, IL12RB2, IL2
43
Show member pathways
7.0IFNG, IFNGR1, IL10, IL12RB1, IL12RB2, IL2
44
Show member pathways
6.8CD2, IFNG, IFNGR1, IL10, IL12RB1, IL12RB2
45
Show member pathways
6.8CD2, IFNG, IFNGR1, IL10, IL12RB1, IL12RB2
46
Show member pathways
6.8ICAM1, IFNG, IFNGR1, IL12RB1, IL12RB2, IL2
47
Show member pathways
6.5ICAM1, IFNG, IFNGR1, IL10, IL12RB1, IL12RB2

GO Terms for genes affiliated with Lepromatous Leprosy

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Cellular components related to Lepromatous Leprosy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:00058877.8CD2, ICAM1, IFNGR1, IL12RB2, TLR2, TNF
2external side of plasma membraneGO:00098977.7CD2, ICAM1, IFNG, IL12RB1, IL12RB2, TNF

Biological processes related to Lepromatous Leprosy according to GeneCards Suite gene sharing:

(show all 34)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-12 productionGO:003273510.5IFNG, TLR2
2positive regulation of chemokine productionGO:003272210.5TLR2, TNF
3positive regulation of vitamin D biosynthetic processGO:006055710.5IFNG, TNF
4positive regulation of calcidiol 1-monooxygenase activityGO:006055910.5IFNG, TNF
5positive regulation of isotype switching to IgG isotypesGO:004830410.5IFNG, IL2
6positive regulation of membrane protein ectodomain proteolysisGO:005104410.5IFNG, TNF
7positive regulation of chemokine biosynthetic processGO:004508010.5IFNG, TNF
8positive regulation of NF-kappaB import into nucleusGO:004234610.4TLR2, TNF
9receptor biosynthetic processGO:003280010.4IL10, TNF
10negative regulation of cytokine secretion involved in immune responseGO:000274010.4IL10, TNF
11positive regulation of MHC class II biosynthetic processGO:004534810.4IFNG, IL10
12defense response to protozoanGO:004283210.4IFNG, IL10
13protein import into nucleus, translocationGO:000006010.4IFNG, TNF
14positive regulation of osteoclast differentiationGO:004567210.4IFNG, TNF
15positive regulation of cytokine secretionGO:005071510.3IL10, TNF
16natural killer cell activationGO:003010110.3CD2, IL2
17negative regulation of interleukin-6 productionGO:003271510.3IL10, TNF
18negative regulation of endothelial cell apoptotic processGO:200035210.2ICAM1, IL10
19regulation of interferon-gamma-mediated signaling pathwayGO:006033410.2IFNG, IFNGR1
20positive regulation of interleukin-8 productionGO:003275710.1TLR2, TNF
21negative regulation of growth of symbiont in hostGO:004413010.0IFNG, IL10, TNF
22positive regulation of tumor necrosis factor productionGO:003276010.0CD2, IFNG, TLR2
23positive regulation of activated T cell proliferationGO:004210410.0IL12RB1, IL2
24defense response to bacteriumGO:00427429.9IFNG, IL10, TNF
25positive regulation of NF-kappaB transcription factor activityGO:00510929.7ICAM1, TLR2, TNF
26interferon-gamma-mediated signaling pathwayGO:00603339.6ICAM1, IFNG, IFNGR1
27response to virusGO:00096159.5IFNG, IFNGR1, TNF
28positive regulation of nitric oxide biosynthetic processGO:00454299.5ICAM1, IFNG, TNF
29cellular response to lipopolysaccharideGO:00712229.5ICAM1, IFNG, IL10, TNF
30response to lipopolysaccharideGO:00324969.3ICAM1, IL10, IL12RB2, TLR2
31leukocyte migrationGO:00509009.2CD2, ICAM1, TNF
32positive regulation of interferon-gamma productionGO:00327299.2IL12RB1, IL12RB2, IL2, TNF
33positive regulation of gene expressionGO:00106288.9IFNG, TLR2, TNF, VDR
34positive regulation of transcription from RNA polymerase II promoterGO:00459448.3IFNG, IL10, IL2, TLR2, TNF, VDR

Molecular functions related to Lepromatous Leprosy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine receptor activityGO:00048969.4IL12RB1, IL12RB2
2cytokine activityGO:00051259.1IFNG, IL10, IL2, TNF

Sources for Lepromatous Leprosy

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2CDC
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