MCID: LPR001
MIFTS: 47

Lepromatous Leprosy malady

Infectious diseases category

Aliases & Classifications for Lepromatous Leprosy

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Sources:
10Disease Ontology, 47Novoseek, 65UMLS, 36MeSH, 59SNOMED-CT, 29ICD9CM, 27ICD10
See all sources

Aliases & Descriptions for Lepromatous Leprosy:

Name: Lepromatous Leprosy 10
Leprosy, Lepromatous 65 36
 
Leprosy Lepromatous 47
Type L Leprosy 10


Classifications:



External Ids:

Disease Ontology10 DOID:10887
ICD9CM29 030.0
SNOMED-CT59 21560005
MeSH36 D015440
ICD1027 A30.5

Summaries for Lepromatous Leprosy

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Disease Ontology:10 A leprosy that results in early cutaneous lesions which consist of pale macules that are small, diffuse, and symmetric. this form of leprosy is characterized by hypoesthesia over extensor surfaces of the distal extremities, alopecia affecting lateral aspects of the eyebrows, saddle-nose deformity and oral lepromas.

MalaCards based summary: Lepromatous Leprosy, also known as leprosy, lepromatous, is related to leprosy and hepatitis. An important gene associated with Lepromatous Leprosy is TLR2 (Toll-Like Receptor 2), and among its related pathways are LDL Oxidation in Atherogenesis and OX40 Pathway. The drugs clofazimine and dapsone have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and monocytes, and related mouse phenotypes are muscle and integument.

Wikipedia:68 Lepromatous leprosy is a skin condition consisting of pale macules. more...

Related Diseases for Lepromatous Leprosy

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Diseases related to Lepromatous Leprosy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 265)
idRelated DiseaseScoreTop Affiliating Genes
1leprosy32.0IFNG, IL10, IL12RB2, IL2, TLR2, TNF
2hepatitis31.0IFNG, IL10, TNF
3chromoblastomycosis30.6ICAM1, TNF
4hydrocele30.5IFNG, IL2, TNF
5tuberculosis30.4ICAM1, IFNG, IL10, IL2, TLR2, TNF
6mycosis fungoides30.4IFNG, IL10, IL2, TNF
7cutaneous leishmaniasis30.3IFNG, IL10, IL12RB2, TNF
8systemic lupus erythematosus30.2ICAM1, IFNG, IL10, IL2, TNF
9pulmonary tuberculosis10.5
10molluscum contagiosum10.5
11lupus erythematosus10.5
12tetanus10.5
13sinusitis10.4
14tuberculoid leprosy10.4
15leishmaniasis10.4
16glomerulonephritis10.4
17sporotrichosis10.4
18mononeuritis multiplex10.4
19multicentric reticulohistiocytosis10.4
20mononeuritis10.4
21syphilis10.4
22dysautonomia10.4
23acute conjunctivitis10.3IFNG, TLR2
24punctate porokeratosis10.3IL10, TNF
25stargardt macular degeneration absent or hypoplastic corpus callosum mental retardation and dysmorphic features10.3IFNG, TNF
26primary progressive freezing gait10.3IL10, TNF
27autoimmune oophoritis10.3IFNG, TNF
28best1 retinopathy10.3IFNG, TNF
29anti-hla hyperimmunization10.3TLR2, TNF
30hair defect with photosensitivity and mental retardation10.3TLR2, TNF
31hepatic tuberculosis10.3IL2, TNF
32sensorineural hearing loss10.3IFNG, IL10
33mycobacterium chelonae10.3TLR2, TNF
34microsomia hemifacial radial defects10.3IL10, TNF
35multifocal lymphangioendotheliomatosis with thrombocytopenia10.3IL10, TNF
36tuberculous uveitis10.3TLR2, TNF
37scleroderma10.3IFNG, TNF
38intrapelvic lymph node leukemic reticuloendotheliosis10.3IL10, TNF
39sleeping sickness10.3IL10, TNF
40hyper-reninism10.3IFNG, TLR2
41neurotic excoriation10.3IL10, TNF
42noonan syndrome 210.3TLR2, TNF
43intermediate anorectal malformation10.3IL10, TNF
44malignant sertoli-leydig cell tumor of ovary10.3IL2, TNF
4546 xx gonadal dysgenesis10.3IL2, TNF
46testicular leukemia10.3IFNG, TNF
47buruli ulcer10.3IFNG, IL10
48chronic hiccups10.3IFNG, IL10
49pneumonic tularemia10.3IFNG, TNF
50intermediate cell type choroid melanoma10.2IL2, TNF

Graphical network of the top 20 diseases related to Lepromatous Leprosy:



Diseases related to lepromatous leprosy

Symptoms for Lepromatous Leprosy

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Drugs & Therapeutics for Lepromatous Leprosy

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Drugs for Lepromatous Leprosy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Clofazimineapproved, investigationalPhase 4192030-63-92794
Synonyms:
(3Z)-N,5-bis(4-chlorophenyl)-3-[(1-methylethyl)imino]-3,5-dihydrophenazin-2-amine
2030-63-9
3-(p-Chloranilino)-10-(p-chlorophenyl)-2,10-dihydro-2-(isopropylimino)-phenazine
3-(p-Chloranilino)-10-(p-chlorophenyl)-2,10-dihydro-2-(isopropylimino)phenazine
3-(p-Chloranilino)-10-(p-chlorphenyl)-2,10-dihydro-2-(isopropylimino)-phenazin
3-(p-Chloranilino)-10-(p-chlorphenyl)-2,10-dihydro-2-(isopropylimino)-phenazin [German]
3-(p-Chloroanilino)-10-(p-chlorophenyl)-2,10-dihydro-2-(isopropylimino)phenazine
4-25-00-03033 (Beilstein Handbook Reference)
AC1L1EHE
B 663
B 663 (Pharmaceutical)
B 663 (VAN)
B 663, pharmaceutical
B-663
B. 663
B663
BIDD:PXR0147
BPBio1_000585
BRN 0060420
BSPBio_000531
C06915
C27H22Cl2N4
C8895_SIGMA
CAS-2030-63-9
CFZ
CHEBI:3749
CHEBI:730395
CHEMBL1083384
CHEMBL1292
CID2794
CPD000058704
Chlofazimine
Clofazimin
Clofazimina
Clofazimina [INN-Spanish]
Clofazimine
Clofazimine (JAN/USP/INN)
Clofazimine [USAN:INN:BAN]
Clofaziminum
Clofaziminum [INN-Latin]
 
D00278
DB00845
EINECS 217-980-2
G 30320
G-30,320
G-30320
HMS1569K13
HMS2052B05
HMS2093J10
I06-1891
LS-103014
Lampren
Lamprene
Lamprene (TN)
Liposome-encapsulated clofazimine
MLS000028617
MLS001424318
N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-(1-methylethyl)imino)-2-phenazinamine
N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-(isopropylimino)phenazin-2-amine
N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-[(1-methylethyl)imino]-2-phenazinamine
N,5-bis(4-chlorophenyl)-3-(propan-2-ylimino)-3,5-dihydrophenazin-2-amine
N,5-bis(4-chlorophenyl)-3-propan-2-yliminophenazin-2-amine
NCGC00016600-01
NCGC00016600-02
NCGC00179529-01
NSC 141046
NSC-141046
NSC141046
Prestwick0_000376
Prestwick1_000376
Prestwick2_000376
Prestwick3_000376
Prestwick_685
Riminophenazine
SAM001246878
SMP2_000339
SMR000058704
SPBio_002452
ST51014966
UNII-D959AE5USF
clofazimine
2
Nitroprussideapproved5715078-28-111963622
Synonyms:
13755-38-9 (di-hydrochloride salt, diH20)
14402-89-2 (di-hydrochloride salt)
15078-28-1
C07269
CHEMBL74115
CID11953891
Disodium nitroprusside dihydrate
LS-187044
Nipride
Nitroferricyanide
 
Nitropress
Nitroprusside
Pentacyanidonitrosylferrate(2-)
Sodium Nitroprusside
Sodium nitroferricyanide dihydrate
Sodium nitroprusside
Sodium nitroprusside dihydrate
Sodium nitroprusside extra pure
UNII-169D1260KM
[Fe(CN)5(NO)](2-)
nitroferricyanide
3
Nitric Oxideapproved54010102-43-9145068
Synonyms:
(.)NO
(NO)(.)
10102-43-9
14332-28-6
295566_ALDRICH
51005-20-0
51005-21-1
53851-19-7
90452-29-2
AC1L1ADQ
AC1L3QHF
AC1Q6QZ0
AR-1K7463
Bioxyde d'azote
Bioxyde d'azote [French]
C00533
CCRIS 4319
CHEMBL1200689
CHEMBL1234765
CID145068
CID945
D00074
D009569
DB00435
EDRF
EINECS 233-271-0
Endogenous Nitrate Vasodilator
Endothelium-Derived Nitric Oxide
HNO
HSDB 1246
INOmax
INOmax (TN)
Inomax
LS-192158
LS-7547
MolPort-003-929-452
Mononitrogen monoxide
Monoxide, Mononitrogen
Monoxide, Nitrogen
Monoxido de nitrogeno
Monoxyde d'azote
NITRIC-OXIDE
NO
NO(.)
Nitrate Vasodilator, Endogenous
Nitric Oxide, Endothelium Derived
 
Nitric Oxide, Endothelium-Derived
Nitric oxide
Nitric oxide (JAN)
Nitric oxide 10% by volume or more
Nitric oxide trimer
Nitric oxide, compressed [UN1660] [Poison gas]
Nitric oxide, compressed [UN1660] [Poison gas]
Nitrogen monoxide
Nitrogen oxide
Nitrogen oxide (NO)
Nitrogen protoxide
Nitrosyl
Nitrosyl hydride
Nitrosyl hydride ((NO)H)
Nitrosyl radical
Nitroxide radical
Nitroxyl
OHM 11771
Oxide, Nitric
Oxido de nitrogeno(ii)
Oxido nitrico
Oxyde azotique
Oxyde nitrique
Oxyde nitrique [French]
RCRA waste no. P076
Stickmonoxyd
Stickmonoxyd [German]
Stickstoff(II)-oxid
Stickstoff(ii)-oxid
Stickstoffmonoxid
UN 1660
UN1660
UNII-31C4KY9ESH
Vasodilator, Endogenous Nitrate
[NO]
endothelium-derived relaxing factor
monoxido de nitrogeno
monoxyde d'azote
nitric oxide
nitrogen monooxide
nitrogen monoxide
nitrosyl
oxido de nitrogeno(II)
oxido nitrico
oxidonitrogen(.)
oxoazanyl
oxyde azotique
4
Acetylcholineexperimental10451-84-3187
Synonyms:
ACh
Acetyl choline ion
Acetylcholine Chloride
Acetylcholine cation
 
Acetylcholinium: acetyl-Choline
Choline acetate
Choline acetate (ester)
Miochol E
O-Acetylcholine
acetylcholine chloride
5Nitric Oxide Donors94

Interventional clinical trials:

idNameStatusNCT IDPhase
1Effect of Additional Clofazimine on Erythema Nodosum Leprosum (ENL) Reactions in LeprosyCompletedNCT01290744Phase 4
2Microcirculatory Impairment in Patients With LeprosyCompletedNCT02085317
3Treatment Protocol for Clofazamine in the Long Term Treatment of LeprosyNo longer availableNCT00852345

Search NIH Clinical Center for Lepromatous Leprosy

Inferred drug relations via UMLS65/NDF-RT43:


Cochrane evidence based reviews: Leprosy, Lepromatous

Genetic Tests for Lepromatous Leprosy

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Anatomical Context for Lepromatous Leprosy

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MalaCards organs/tissues related to Lepromatous Leprosy:

33
Skin, T cells, Monocytes, Bone, Testes, Tongue, Myeloid

Animal Models for Lepromatous Leprosy or affiliated genes

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MGI Mouse Phenotypes related to Lepromatous Leprosy:

38 (show all 14)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.4HSPD1, ICAM1, IFNG, IL10, TLR2, TNF
2MP:00107718.0ICAM1, IFNG, IFNGR1, IL10, TLR2, TNF
3MP:00053708.0IFNG, IFNGR1, IL10, IL12RB2, IL2, TLR2
4MP:00053867.6HSPD1, IFNG, IFNGR1, IL10, IL2, TLR2
5MP:00053897.5HSPD1, IFNG, IFNGR1, IL10, IL2, TNF
6MP:00053817.5ICAM1, IFNG, IFNGR1, IL10, IL12RB2, IL2
7MP:00053857.4ICAM1, IFNG, IFNGR1, IL10, IL12RB2, IL2
8MP:00053847.3HSPD1, ICAM1, IFNG, IFNGR1, IL10, IL2
9MP:00020067.3ICAM1, IFNG, IFNGR1, IL10, IL12RB2, IL2
10MP:00053797.1ICAM1, IFNG, IFNGR1, IL10, IL12RB2, IL2
11MP:00053766.6ICAM1, IFNG, IFNGR1, IL10, IL12RB1, IL12RB2
12MP:00053876.5ICAM1, IFNG, IFNGR1, IL10, IL12RB1, IL12RB2
13MP:00053976.5ICAM1, IFNG, IFNGR1, IL10, IL12RB1, IL12RB2

Publications for Lepromatous Leprosy

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Articles related to Lepromatous Leprosy:

(show top 50)    (show all 527)
idTitleAuthorsYear
1
Oral manifestation of lepromatous leprosy: diagnosis and management. (24848267)
2014
2
Lepromatous leprosy and perianal tuberculosis: a case report and literature review. (25180030)
2014
3
Lepromatous leprosy treated with combined chemotherapy and immunotherapy (injection BCG): three case reports. (23675902)
2014
4
Borderline lepromatous leprosy with type 1 (downgrading) reaction. (24252148)
2013
5
Deck chair sign in lepromatous leprosy. (24428120)
2013
6
A delayed diagnosis of lepromatous leprosy: pitfalls and clues to early recognition. (22004493)
2011
7
UVB susceptibility as a risk factor to the development of lepromatous leprosy. (21308307)
2010
8
SNP 668C (-44) alters a NF-kappaB1 putative binding site in non-coding strand of human beta-defensin 1 (DEFB1) and is associated with lepromatous leprosy. (19460328)
2009
9
Lepromatous leprosy with erythema nodosum leprosum as immune reconstitution inflammatory syndrome in an HIV-1 infected patient after initiation of antiretroviral therapy. (22132023)
2009
10
Lichen scrofulosorum in a patient with lepromatous leprosy after BCG immunotherapy. (16038252)
2005
11
Histopathological study of apparently normal oral mucosa in lepromatous leprosy. (16375230)
2005
12
Lepromatous leprosy with extensive unusual ulcerations and cachexia. Is it the first case of Lucio's phenomenon from Iran? (15217312)
2004
13
Intra-abdominal, crystal-storing histiocytosis due to clofazimine in a patient with lepromatous leprosy and concurrent carcinoma of the colon. (15282969)
2004
14
Molluscum contagiosum-like lesions in lepromatous leprosy. (15267197)
2003
15
Near-nerve potential in lepromatous leprosy. (14506718)
2003
16
Multicentric reticulohistiocytosis misdiagnosed as lepromatous leprosy. (15267195)
2003
17
Ocular complications in newly diagnosed borderline lepromatous and lepromatous leprosy patients: baseline profile of the Indian cohort. (12446359)
2002
18
Localized linear lesions in lepromatous leprosy. (11898466)
2001
19
Cutaneous cryptococcosis associated with lepromatous leprosy. (11589749)
2001
20
Anetoderma secondary to lepromatous leprosy. (11326598)
2001
21
Increased lipid peroxidation in lepromatous leprosy. (20877051)
2000
22
Fine-needle aspiration cytology of lepromatous leprosy. (9715599)
1998
23
Rare transcripts of interferon-gamma detected in lepromatous leprosy cases. (9614846)
1998
24
Diffuse alopecia of the scalp in borderline-lepromatous leprosy in an Indian patient. (9503871)
1997
25
Abnormalities of the sympathetic skin response in lepromatous leprosy. (8808668)
1996
26
Localized borderline lepromatous leprosy. (8537706)
1995
27
Lymphangiographic evaluation of patients with clinical lepromatous leprosy on clofazimine. (8189086)
1994
28
Tongue involvement in lepromatous leprosy. (8425797)
1993
29
Electrocardiographic alterations in lepromatous leprosy patients with concomitant Trypanosoma cruzi infection. (8228450)
1993
30
Loss of viability of Mycobacterium leprae isolated from nasal secretions of lepromatous leprosy patients following daily rifampicin and DDS therapy. (8127217)
1993
31
Lepromatous leprosy: nasal manifestations and treatment with minocycline. (1543336)
1992
32
A histopathological and immunological profile of a single lesion lepromatous leprosy (LLs). (1802946)
1991
33
Saber tibiae in lepromatous leprosy. (2376687)
1990
34
Histoid lepromas of lepromatous leprosy. (2228377)
1990
35
Single lesion subpolar lepromatous leprosy and its possible mode of origin. (2659697)
1989
36
Mechanisms of Mycobacterium leprae-specific T-cell deficiency in lepromatous leprosy. (3147697)
1988
37
Facies leprosa: resorption of maxillary anterior alveolar bone and the anterior nasal spine in patients with lepromatous leprosy in Mali. (3373085)
1988
38
Estimation of high density lipoprotein cholesterol in the diagnosis of lepromatous leprosy. (3253340)
1988
39
Effect of deoxyfructoserotonin (DFS) on lepromatous leprosy. (2894551)
1988
40
Evidence of cell-mediated immune contrasuppression in lepromatous leprosy: modulation of a putative T contrasuppressor cell-subset. (3133142)
1988
41
Hyperbaric oxygenation (HBO) as a complementary treatment of patients with multibacillary lepromatous leprosy. (3507902)
1987
42
Evaluation of anti-cardiolipin antibody and its cross-reactivity in sera of patients with lepromatous leprosy. (3740940)
1986
43
Failure of specific antigen presentation in lepromatous leprosy. (3702586)
1986
44
Lepromatous leprosy: follow-up rate in 84 patients. (3784759)
1986
45
Lepromatous leprosy: study of some subpopulations of lymphocytes and their functional analysis. (2934039)
1985
46
Detection of phenolic glycolipid I in sera from patients with lepromatous leprosy. (3900237)
1985
47
Preliminary evidence of natural resistance to Mycobacterium bovis (BCG) in lepromatous leprosy. (6373625)
1984
48
Defective production of monocyte-activating cytokines in lepromatous leprosy. (6366107)
1984
49
Mononeuritis multiplex in lepromatous leprosy. (5690422)
1968
50
Mononeuritis multiplex in lepromatous leprosy. (4301578)
1968

Variations for Lepromatous Leprosy

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Expression for genes affiliated with Lepromatous Leprosy

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Search GEO for disease gene expression data for Lepromatous Leprosy.

Pathways for genes affiliated with Lepromatous Leprosy

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Pathways related to Lepromatous Leprosy according to GeneCards Suite gene sharing:

(show all 44)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5ICAM1, TNF
29.5IFNG, IL10, IL2
39.5IFNG, TLR2, TNF
4
Show member pathways
9.4IFNG, IL2, TNF
5
Show member pathways
9.4IFNG, IL2, TNF
69.3ICAM1, IFNG, IL2
7
Show member pathways
9.3IFNG, IL12RB1, TLR2
89.3HSPD1, TLR2, TNF
9
Show member pathways
9.2ICAM1, IFNG, TNF
109.2HSPD1, IL10, TNF
119.2IFNG, IL12RB1, IL12RB2
12
Show member pathways
9.2IL12RB1, IL12RB2, IL2
139.1IFNG, IL10, TLR2, TNF
14
Show member pathways
9.1IFNG, IL10, IL2, TNF
159.1IFNG, IL10, IL2, TNF
16
Show member pathways
9.1IFNG, IL10, IL2, TNF
17
B cell receptor signaling pathway (KEGG)
Show member pathways
9.1IFNG, IL10, IL2, TNF
189.0ICAM1, IFNG, TLR2, TNF
198.9IFNG, IFNGR1, TNF
20
Show member pathways
8.9IFNG, IFNGR1, TNF
218.9ICAM1, IFNG, IL2, TNF
228.9ICAM1, IFNG, IL2, TNF
238.9ICAM1, IFNG, IL10, TNF
24
Show member pathways
8.9IFNG, IL12RB1, IL12RB2, IL2
25
Show member pathways
8.8ICAM1, IFNG, IFNGR1
268.8ICAM1, IFNG, IFNGR1
278.8IFNG, IL10, IL2, TLR2, TNF
28
Show member pathways
8.7IFNG, IFNGR1, TLR2, TNF
298.7IFNG, IFNGR1, TLR2, TNF
308.6ICAM1, IFNG, IL10, TLR2, TNF
31
Show member pathways
8.5IFNG, IL10, IL12RB1, IL2, TNF
32
Show member pathways
8.3IFNG, IFNGR1, IL2, TLR2, TNF
33
Show member pathways
8.3IFNG, IFNGR1, IL10, TLR2, TNF
34
Show member pathways
8.1ICAM1, IFNG, IFNGR1, IL2, TNF
35
Show member pathways
8.0IFNG, IFNGR1, IL10, IL2, TLR2, TNF
36
Show member pathways
7.9CD2, IL10, IL12RB1, IL12RB2, IL2, TNF
37
Show member pathways
7.8ICAM1, IFNG, IFNGR1, IL2, TLR2, TNF
387.8HSPD1, IFNG, IFNGR1, IL10, TLR2, TNF
39
Show member pathways
7.7IFNG, IFNGR1, IL10, IL12RB1, IL12RB2, IL2
40
Show member pathways
7.7CD2, IL10, IL12RB1, IL12RB2, IL2, TLR2
41
Show member pathways
7.0IFNG, IFNGR1, IL10, IL12RB1, IL12RB2, IL2
42
Show member pathways
6.8CD2, IFNG, IFNGR1, IL10, IL12RB1, IL12RB2
43
Show member pathways
6.8CD2, IFNG, IFNGR1, IL10, IL12RB1, IL12RB2
44
Show member pathways
6.0HSPD1, ICAM1, IFNG, IFNGR1, IL10, IL12RB1

GO Terms for genes affiliated with Lepromatous Leprosy

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Cellular components related to Lepromatous Leprosy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.1HSPD1, ICAM1, IFNG, IL10, IL2, TNF
2cell surfaceGO:00099868.0CD2, HSPD1, ICAM1, TLR2, TNF
3external side of plasma membraneGO:00098977.9CD2, ICAM1, IFNG, IL12RB1, IL12RB2, TLR2
4integral component of plasma membraneGO:00058877.7CD2, ICAM1, IFNGR1, IL12RB2, TLR2, TNF

Biological processes related to Lepromatous Leprosy according to GeneCards Suite gene sharing:

(show all 42)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of interleukin-17 productionGO:003270010.5IFNG, TLR2
2positive regulation of vitamin D biosynthetic processGO:006055710.5IFNG, TNF
3negative regulation of interleukin-12 productionGO:003269510.5IL10, TLR2
4positive regulation of calcidiol 1-monooxygenase activityGO:006055910.5IFNG, TNF
5positive regulation of MHC class II biosynthetic processGO:004534810.5IFNG, IL10
6positive regulation of chemokine productionGO:003272210.4TLR2, TNF
7positive regulation of chemokine biosynthetic processGO:004508010.4IFNG, TNF
8receptor biosynthetic processGO:003280010.4IL10, TNF
9positive regulation of isotype switching to IgG isotypesGO:004830410.4IFNG, IL2
10positive regulation of membrane protein ectodomain proteolysisGO:005104410.4IFNG, TNF
11protein import into nucleus, translocationGO:000006010.4IFNG, TNF
12positive regulation of NF-kappaB import into nucleusGO:004234610.4TLR2, TNF
13defense response to protozoanGO:004283210.4IFNG, IL10
14lipopolysaccharide-mediated signaling pathwayGO:003166310.4TLR2, TNF
15negative regulation of cytokine secretion involved in immune responseGO:000274010.4IL10, TNF
16positive regulation of interleukin-8 productionGO:003275710.3TLR2, TNF
17natural killer cell activationGO:003010110.3CD2, IL2
18negative regulation of interleukin-6 productionGO:003271510.2IL10, TNF
19negative regulation of endothelial cell apoptotic processGO:200035210.2ICAM1, IL10
20positive regulation of osteoclast differentiationGO:004567210.2IFNG, TNF
21positive regulation of activated T cell proliferationGO:004210410.1IL12RB1, IL2
22positive regulation of cytokine secretionGO:005071510.0IL10, TLR2, TNF
23regulation of interferon-gamma-mediated signaling pathwayGO:006033410.0IFNG, IFNGR1
24positive regulation of interleukin-12 productionGO:00327359.9HSPD1, IFNG, TLR2
25positive regulation of inflammatory responseGO:00507299.9HSPD1, IL2, TLR2
26positive regulation of tumor necrosis factor productionGO:00327609.8CD2, IFNG, TLR2
27positive regulation of NF-kappaB transcription factor activityGO:00510929.7ICAM1, TLR2, TNF
28defense response to bacteriumGO:00427429.7IFNG, IL10, TNF
29positive regulation of interleukin-6 productionGO:00327559.6HSPD1, TLR2, TNF
30negative regulation of growth of symbiont in hostGO:00441309.6IFNG, IL10, TLR2, TNF
31leukocyte migrationGO:00509009.5CD2, ICAM1, TNF
32interferon-gamma-mediated signaling pathwayGO:00603339.4ICAM1, IFNG, IFNGR1
33cell surface receptor signaling pathwayGO:00071669.3CD2, IFNG, IL12RB2, TNF
34cellular response to lipopolysaccharideGO:00712229.3ICAM1, IFNG, IL10, TNF
35positive regulation of nitric oxide biosynthetic processGO:00454299.2ICAM1, IFNG, TLR2, TNF
36immune responseGO:00069559.1IFNG, IL10, IL2, TLR2, TNF
37response to lipopolysaccharideGO:00324969.1HSPD1, ICAM1, IL10, IL12RB2
38response to virusGO:00096158.9IFNG, IFNGR1, TNF
39positive regulation of interferon-gamma productionGO:00327298.8HSPD1, IL12RB1, IL12RB2, IL2, TNF
40positive regulation of transcription from RNA polymerase II promoterGO:00459448.8IFNG, IL10, IL2, TLR2, TNF
41response to drugGO:00424938.5HSPD1, ICAM1, IFNG, IL10
42cytokine-mediated signaling pathwayGO:00192217.7ICAM1, IFNG, IFNGR1, IL12RB1, IL12RB2

Molecular functions related to Lepromatous Leprosy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide bindingGO:00015309.7HSPD1, TLR2
2cytokine activityGO:00051259.1IFNG, IL10, IL2, TNF
3cytokine bindingGO:00199558.7IFNGR1, IL12RB1

Sources for Lepromatous Leprosy

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet