MCID: LPR001
MIFTS: 50

Lepromatous Leprosy malady

Category: Infectious diseases

Aliases & Classifications for Lepromatous Leprosy

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Aliases & Descriptions for Lepromatous Leprosy:

Name: Lepromatous Leprosy 11 13
Leprosy, Lepromatous 39 68
 
Leprosy Lepromatous 50
Type L Leprosy 11

Classifications:



External Ids:

Disease Ontology11 DOID:10887
ICD1030 A30.5
SNOMED-CT62 21560005
ICD9CM32 030.0
MeSH39 D015440

Summaries for Lepromatous Leprosy

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Disease Ontology:11 A leprosy that results in early cutaneous lesions which consist of pale macules that are small, diffuse, and symmetric. This form of leprosy is characterized by hypoesthesia over extensor surfaces of the distal extremities, alopecia affecting lateral aspects of the eyebrows, saddle-nose deformity and oral lepromas.

MalaCards based summary: Lepromatous Leprosy, also known as leprosy, lepromatous, is related to tuberculosis and pulmonary tuberculosis. An important gene associated with Lepromatous Leprosy is TLR2 (Toll Like Receptor 2), and among its related pathways are IL12 signaling mediated by STAT4 and LDL Oxidation in Atherogenesis. The drugs dapsone and clofazimine have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and monocytes, and related mouse phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and muscle.

Wikipedia:71 Lepromatous leprosy is a skin condition consisting of pale . Its a systemic disease.macules. more...

Related Diseases for Lepromatous Leprosy

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Diseases related to Lepromatous Leprosy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 258)
idRelated DiseaseScoreTop Affiliating Genes
1tuberculosis30.6IL10, IL2, TNF
2pulmonary tuberculosis30.3IFNG, IL10, TNF
3hepatitis30.2IFNG, IL10, IL2, TNF
4lagophthalmos30.0IL10, TNF
5anaplastic large cell lymphoma29.3ICAM1, IFNG, IL2, TNF, VDR
6leprosy11.5
7pyridoxal 5'-phosphate-dependent epilepsy10.3IL10, TNF
8tubular renal disease-cardiomyopathy syndrome10.3IL10, TNF
9nguyen syndrome10.3IL10, TLR2
10steatitis10.3IL2, TNF
11stocco dos santos syndrome10.3IFNG, TNF
12asymptomatic neurosyphilis10.3IFNG, IL10
13multiple vertebral anomalies unusual facies10.3IL10, TNF
14distal trisomy 14q10.3IFNG, TNF
15conidiobolomycosis10.2IL10, TNF
16paralytic poliomyelitis10.2IFNG, IL2
17caplan's syndrome10.2IFNG, IL2
18endosalpingiosis10.2IL10, TNF
19thymic neuroendocrine carcinoma10.2IL2, TNF
20idiopathic hypertrophic pachymeningitis10.2IL10, TNF
21hemangioma of orbit10.2IL2, TNF
22spotted fever10.2TLR2, TNF
23congenital hypothyroidism10.2IL10, TLR2, TNF
24tungiasis10.2IFNG, IL10
25inappropriate adh syndrome10.2IL10, TLR2, TNF
26atrophy of prostate10.2IL10, TLR2, TNF
27peripheral artery disease10.2IL10, TLR2, TNF
28osteodysplasty precocious of danks mayne and kozlowski10.2IFNG, IL10, TNF
29oral cavity carcinoma in situ10.2IFNG, IL10, TLR2
30parkinson disease 1110.2IFNG, IL10, TNF
31vestibule of mouth cancer10.2IL10, TNF
32usher syndrome, type 2a10.2IFNG, IL10, TLR2
33senile reticular retinal degeneration10.2IFNG, IL10, TNF
34pancreatic signet ring cell adenocarcinoma10.2IFNG, IL10, TNF
35pulpitis10.2IFNG, IL10, TNF
36endogenous depression10.2IL2, TLR2, TNF
37autosomal dominant deafness-onychodystrophy syndrome10.2IFNG, IL2, TNF
38ectodermal dysplasia bartalos type10.2IFNG, IL10, TNF
39hereditary alpha tryptasemia syndrome10.2IFNG, IL10, TNF
40unilateral hypoactive labyrinth10.2IL10, TLR2, TNF
41plummer's disease10.2IFNG, IL10, TNF
42clostridium difficile colitis10.2IFNG, IL2, TNF
43amyotrophic lateral sclerosis type 1410.2IFNG, IL2, TNF
44chromophobe adenoma10.2ICAM1, IL2
45parametritis10.2IFNG, IL2, TNF
46asbestosis10.2IL10, TLR2, TNF
47follicular adenoma10.2IFNG, IL10, TNF
48motor peripheral neuropathy10.2IFNG, IL10, TNF
49inflammatory bowel disease 210.2IFNG, IL10, TLR2
50depressed scar10.2IFNG, IL10, TNF

Graphical network of the top 20 diseases related to Lepromatous Leprosy:



Diseases related to lepromatous leprosy

Symptoms & Phenotypes for Lepromatous Leprosy

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GenomeRNAi Phenotypes related to Lepromatous Leprosy according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00250-A-18.5CD2, ICAM1, IL10, IL2, TNF

MGI Mouse Phenotypes related to Lepromatous Leprosy according to GeneCards Suite gene sharing:

41 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.9ICAM1, IFNG, IL10, TLR2, TNF, VDR
2MP:00053708.6IFNG, IFNGR1, IL10, IL12RB2, IL2, TLR2
3MP:00107718.3ICAM1, IFNG, IFNGR1, IL10, TLR2, TNF
4MP:00020068.0ICAM1, IFNG, IFNGR1, IL10, IL12RB2, IL2
5MP:00053848.0ICAM1, IFNG, IFNGR1, IL10, IL2, TLR2
6MP:00053867.8IFNG, IFNGR1, IL10, IL12RB1, IL2, TLR2
7MP:00053857.6ICAM1, IFNG, IFNGR1, IL10, IL12RB2, IL2
8MP:00053817.6ICAM1, IFNG, IFNGR1, IL10, IL12RB2, IL2
9MP:00053797.6ICAM1, IFNG, IFNGR1, IL10, IL12RB2, IL2
10MP:00053976.8ICAM1, IFNG, IFNGR1, IL10, IL12RB1, IL12RB2
11MP:00053766.8ICAM1, IFNG, IFNGR1, IL10, IL12RB1, IL12RB2
12MP:00053876.8ICAM1, IFNG, IFNGR1, IL10, IL12RB1, IL12RB2

Drugs & Therapeutics for Lepromatous Leprosy

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Drugs for Lepromatous Leprosy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Clofazimineapproved, investigationalPhase 4242030-63-92794
Synonyms:
(3Z)-N,5-bis(4-chlorophenyl)-3-[(1-methylethyl)imino]-3,5-dihydrophenazin-2-amine
2030-63-9
3-(p-Chloranilino)-10-(p-chlorophenyl)-2,10-dihydro-2-(isopropylimino)-phenazine
3-(p-Chloranilino)-10-(p-chlorophenyl)-2,10-dihydro-2-(isopropylimino)phenazine
3-(p-Chloranilino)-10-(p-chlorphenyl)-2,10-dihydro-2-(isopropylimino)-phenazin
3-(p-Chloranilino)-10-(p-chlorphenyl)-2,10-dihydro-2-(isopropylimino)-phenazin [German]
3-(p-Chloroanilino)-10-(p-chlorophenyl)-2,10-dihydro-2-(isopropylimino)phenazine
4-25-00-03033 (Beilstein Handbook Reference)
AC1L1EHE
B 663
B 663 (Pharmaceutical)
B 663 (VAN)
B 663, pharmaceutical
B-663
B. 663
B663
BIDD:PXR0147
BPBio1_000585
BRN 0060420
BSPBio_000531
C06915
C27H22Cl2N4
C8895_SIGMA
CAS-2030-63-9
CFZ
CHEBI:3749
CHEBI:730395
CHEMBL1083384
CHEMBL1292
CID2794
CPD000058704
Chlofazimine
Clofazimin
Clofazimina
Clofazimina [INN-Spanish]
Clofazimine
Clofazimine (JAN/USP/INN)
Clofazimine [USAN:INN:BAN]
Clofaziminum
Clofaziminum [INN-Latin]
 
D00278
DB00845
EINECS 217-980-2
G 30320
G-30,320
G-30320
HMS1569K13
HMS2052B05
HMS2093J10
I06-1891
LS-103014
Lampren
Lamprene
Lamprene (TN)
Liposome-encapsulated clofazimine
MLS000028617
MLS001424318
N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-(1-methylethyl)imino)-2-phenazinamine
N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-(isopropylimino)phenazin-2-amine
N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-[(1-methylethyl)imino]-2-phenazinamine
N,5-bis(4-chlorophenyl)-3-(propan-2-ylimino)-3,5-dihydrophenazin-2-amine
N,5-bis(4-chlorophenyl)-3-propan-2-yliminophenazin-2-amine
NCGC00016600-01
NCGC00016600-02
NCGC00179529-01
NSC 141046
NSC-141046
NSC141046
Prestwick0_000376
Prestwick1_000376
Prestwick2_000376
Prestwick3_000376
Prestwick_685
Riminophenazine
SAM001246878
SMP2_000339
SMR000058704
SPBio_002452
ST51014966
UNII-D959AE5USF
clofazimine
2Anti-Bacterial AgentsPhase 411226
3VitaminsPhase 45282
4Anti-Inflammatory AgentsPhase 410729
5Anti-Infective AgentsPhase 422062
6
Acetylcholineapproved80551-84-3187
Synonyms:
ACh
Acetyl choline ion
Acetylcholine Chloride
Acetylcholine cation
 
Acetylcholinium: acetyl-Choline
Choline acetate
Choline acetate (ester)
O-Acetylcholine
acetylcholine chloride
7
Nitroprussideapproved6415078-28-111963622
Synonyms:
13755-38-9 (di-hydrochloride salt, diH20)
14402-89-2 (di-hydrochloride salt)
15078-28-1
C07269
CHEMBL74115
CID11953891
Disodium nitroprusside dihydrate
LS-187044
Nipride
 
Nitroferricyanide
Nitropress
Nitroprusside
Pentacyanidonitrosylferrate(2-)
Sodium Nitroprusside
Sodium nitroferricyanide dihydrate
Sodium nitroprusside dihydrate
Sodium nitroprusside extra pure
UNII-169D1260KM
[Fe(CN)5(NO)](2-)
nitroferricyanide
8
Nitric Oxideapproved61710102-43-9145068
Synonyms:
(.)NO
(NO)(.)
10102-43-9
14332-28-6
295566_ALDRICH
51005-20-0
51005-21-1
53851-19-7
90452-29-2
AC1L1ADQ
AC1L3QHF
AC1Q6QZ0
AR-1K7463
Bioxyde d'azote
Bioxyde d'azote [French]
C00533
CCRIS 4319
CHEMBL1200689
CHEMBL1234765
CID145068
CID945
D00074
D009569
DB00435
EDRF
EINECS 233-271-0
Endogenous Nitrate Vasodilator
Endothelium-Derived Nitric Oxide
HNO
HSDB 1246
INOmax
INOmax (TN)
LS-192158
LS-7547
MolPort-003-929-452
Mononitrogen monoxide
Monoxide, Mononitrogen
Monoxide, Nitrogen
Monoxido de nitrogeno
Monoxyde d'azote
NITRIC-OXIDE
NO
NO(.)
Nitrate Vasodilator, Endogenous
Nitric Oxide, Endothelium Derived
 
Nitric Oxide, Endothelium-Derived
Nitric oxide
Nitric oxide (JAN)
Nitric oxide 10% by volume or more
Nitric oxide trimer
Nitric oxide, compressed [UN1660] [Poison gas]
Nitric oxide, compressed [UN1660] [Poison gas]
Nitrogen monoxide
Nitrogen oxide
Nitrogen oxide (NO)
Nitrogen protoxide
Nitrosyl
Nitrosyl hydride
Nitrosyl hydride ((NO)H)
Nitrosyl radical
Nitroxide radical
Nitroxyl
OHM 11771
Oxide, Nitric
Oxido de nitrogeno(ii)
Oxido nitrico
Oxyde azotique
Oxyde nitrique
Oxyde nitrique [French]
RCRA waste no. P076
Stickmonoxyd
Stickmonoxyd [German]
Stickstoff(II)-oxid
Stickstoff(ii)-oxid
Stickstoffmonoxid
UN 1660
UN1660
UNII-31C4KY9ESH
Vasodilator, Endogenous Nitrate
[NO]
endothelium-derived relaxing factor
monoxido de nitrogeno
monoxyde d'azote
nitric oxide
nitrogen monooxide
nitrogen monoxide
nitrosyl
oxido de nitrogeno(II)
oxido nitrico
oxidonitrogen(.)
oxoazanyl
oxyde azotique
9Vasodilator Agents3543
10Pharmaceutical Solutions8192
11Antihypertensive Agents4207
12Cholinergic Agents3992
13Neurotransmitter Agents18340
14Nitric Oxide Donors114

Interventional clinical trials:

idNameStatusNCT IDPhase
1Effect of Additional Clofazimine on Erythema Nodosum Leprosum (ENL) Reactions in LeprosyCompletedNCT01290744Phase 4
2Microcirculatory Impairment in Patients With LeprosyCompletedNCT02085317
3Treatment Protocol for Clofazamine in the Long Term Treatment of LeprosyNo longer availableNCT00852345

Search NIH Clinical Center for Lepromatous Leprosy

Inferred drug relations via UMLS68/NDF-RT46:


Cochrane evidence based reviews: leprosy, lepromatous

Genetic Tests for Lepromatous Leprosy

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Anatomical Context for Lepromatous Leprosy

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MalaCards organs/tissues related to Lepromatous Leprosy:

36
Skin, T cells, Monocytes, Bone, Testes, Lymph node, Myeloid

Publications for Lepromatous Leprosy

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Articles related to Lepromatous Leprosy:

(show top 50)    (show all 549)
idTitleAuthorsYear
1
Lepromatous leprosy in a renal transplant recipient. (28449328)
2017
2
Structural and functional changes in the microcirculation of lepromatous leprosy patients - Observation using orthogonal polarization spectral imaging and laser Doppler flowmetry iontophoresis. (28419120)
2017
3
Leg ulcer in lepromatous leprosy - Case report. (27828650)
2016
4
Borderline Lepromatous Leprosy: A Case to Remember. (26888945)
2016
5
Generalized granulomatous dermatitis following Mycobacterium w (Mw) immunotherapy in lepromatous leprosy. (27891733)
2016
6
Hertoghe sign: a hallmark of lepromatous leprosy. (27026695)
2016
7
Mycobacterium leprae-Infected Macrophages Preferentially Primed Regulatory T Cell Responses and Was Associated with Lepromatous Leprosy. (26751388)
2016
8
Association between STR -794 CATT5-8 and SNP -173 G/C polymorphisms in the MIF gene and Lepromatous Leprosy in Mestizo patients of western Mexico. (27426952)
2016
9
A Rare Case of Coexistence of Borderline Lepromatous Leprosy with Tuberculosis Verrucosa Cutis. (28003920)
2016
10
Primary oral tuberculosis in a patient with lepromatous leprosy: Diagnostic dilemma. (26927999)
2016
11
Crusted scabies in a patient with lepromatous leprosy. (27183357)
2016
12
Role of TEFFECTOR/MEMORY Cells, TBX21 Gene Expression and T-Cell Homing Receptor on Type 1 Reaction in Borderline Lepromatous Leprosy Patients. (27764137)
2016
13
Dapsone hypersensitivity syndrome in a lepromatous leprosy patient--A Case Report. (26502691)
2015
14
Lepromatous leprosy: An Unusual Presentation. (26591848)
2015
15
Persistent serpentine supravenous hyperpigmented eruption in lepromatous leprosy after minocycline. (26502692)
2015
16
Disseminated cutaneous BCG infection following BCG immunotherapy in patients with lepromatous leprosy. (26502690)
2015
17
Laryngeal involvement causing dysphonia in a 29 year old nursing mother with lepromatous leprosy. (26327983)
2015
18
Borderline Lepromatous Leprosy with Type 1 (Reversal) Reactions in a Chinese Man. (26251526)
2015
19
Borderline Lepromatous Leprosy: Cutaneous Manifestation and Type 1 Reversal Reaction. (26439279)
2015
20
Diffuse Lepromatous Leprosy Due to Mycobacterium lepromatosis in Quintana Roo, Mexico. (26311856)
2015
21
Osteological, biomolecular and geochemical examination of an early anglo-saxon case of lepromatous leprosy. (25970602)
2015
22
Activation and cytokine profile of monocyte derived dendritic cells in leprosy: in vitro stimulation by sonicated Mycobacterium leprae induces decreased level of IL-12p70 in lepromatous leprosy. (26222022)
2015
23
A Lepromatous Leprosy Patient with Permanent Disability. (26537774)
2015
24
Lymph node abscess and cardiac involvement in a patient with nodular lepromatous leprosy (LL) with erythema nodosum leprosum (ENL): a rare occurrence. (26065155)
2015
25
What is your diagnosis? lepromatous leprosy. (25671446)
2015
26
Pulmonary Tuberculosis and Lepromatous Leprosy Coinfection. (26504603)
2015
27
A case of lepromatous leprosy with co-existing tuberculosis verrucosa cutis (TVC). (26502689)
2015
28
A case of secondary syphilis with HIV, resembling borderline lepromatous leprosy. (26692613)
2015
29
Increase in TGF-I^ secreting CD4a8_CD25a8_ FOXP3a8_ T regulatory cells in anergic lepromatous leprosy patients. (24454972)
2014
30
Case of lepromatous leprosy misdiagnosed as systemic sclerosis. (24480058)
2014
31
Verrucous lepromatous leprosy: a rare form of presentation--report on two cases. (24937824)
2014
32
T-cell regulation in lepromatous leprosy. (24722473)
2014
33
Lepromatous leprosy and perianal tuberculosis: a case report and literature review. (25180030)
2014
34
Oral manifestation of lepromatous leprosy: diagnosis and management. (24848267)
2014
35
Differential dermal expression of CCL17 and CCL18 in tuberculoid and lepromatous leprosy. (25412496)
2014
36
Lepromatous leprosy mimicking systemic lupus erythematosus: a clinical pathology conference held by the division of rheumatology at hospital for special surgery. (25264448)
2014
37
Fulminant hepatic failure in a 15 year old boy with borderline lepromatous leprosy and type 2 reaction. (24974443)
2014
38
Molluscum-like lesions in a 12-year-old boy: challenge. Lepromatous leprosy. (25415139)
2014
39
Novel presentation of lepromatous leprosy in an erythema gyratum repens-like pattern. (24320626)
2014
40
A case of lepromatous leprosy complicated by hemophagocytosis misdiagnosed as hemophagocytic lymphohistiocytosis. (24657272)
2014
41
Lepromatous leprosy associated with erythema nodosum leprosum. (25101350)
2014
42
Lepromatous leprosy treated with combined chemotherapy and immunotherapy (injection BCG): three case reports. (23675902)
2014
43
Deck chair sign in lepromatous leprosy. (24428120)
2013
44
Allopurinol induced granuloma annulare in a patient of lepromatous leprosy. (23761716)
2013
45
Association of genetic polymorphism of HLA-DRB1 antigens with the susceptibility to lepromatous leprosy. (24649058)
2013
46
Optic nerve involvement in a borderline lepromatous leprosy patient on multidrug therapy. (24745131)
2013
47
Basophils infiltrate the skin lesions in lepromatous leprosy. (22513483)
2013
48
Borderline lepromatous leprosy in an Italian man. (23390219)
2013
49
Lepromatous leprosy: A rare presentation in Australia. (23671461)
2013
50
Spontaneous appearance of multiple asymptomatic papules and/or nodules over an apparently normal skin of the trunk. Fibrosing lepromatous leprosy (LL) evolving to histoid leprosy. (23452055)
2013

Variations for Lepromatous Leprosy

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Expression for genes affiliated with Lepromatous Leprosy

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Search GEO for disease gene expression data for Lepromatous Leprosy.

Pathways for genes affiliated with Lepromatous Leprosy

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Pathways related to Lepromatous Leprosy according to GeneCards Suite gene sharing:

(show top 50)    (show all 61)
idSuper pathwaysScoreTop Affiliating Genes
19.9IFNG, IL2
29.6ICAM1, TNF
39.6TNF, VDR
49.5IFNG, TLR2, TNF
59.5IFNG, IL10, IL2
69.5IFNG, IL2, TNF
79.5IFNG, IL2, TNF
8
Show member pathways
9.5IFNG, IL2, TNF
9
Show member pathways
9.5IFNG, IL2, TNF
109.4ICAM1, IFNG, TLR2
119.3ICAM1, IFNG, IL2
129.3ICAM1, IFNG, TNF
139.3IFNG, TNF, VDR
149.2ICAM1, IL10, TNF
159.2ICAM1, IL10, TNF
16
Show member pathways
9.2IFNG, IFNGR1, TNF
17
Show member pathways
9.2IFNG, IFNGR1, TNF
189.2IFNG, IFNGR1, TNF
199.2IFNG, IL10, TLR2, TNF
20
Show member pathways
9.1IFNG, IL10, IL2, TNF
21
Show member pathways
9.1IFNG, IL10, IL2, TNF
22
Show member pathways
9.1IFNG, IL10, IL2, TNF
239.1IFNG, IL10, IL2, TNF
249.1IFNG, IL10, IL2, TNF
259.1IFNG, IL10, IL12RB2, IL2
26
Show member pathways
9.1IFNG, IL12RB1, TLR2
279.0ICAM1, IFNG, IFNGR1
289.0ICAM1, IFNG, TLR2, TNF
299.0CD2, IL10, IL2, TNF
30
Show member pathways
9.0ICAM1, IFNG, IL2, TNF
319.0ICAM1, IFNG, IL2, TNF
32
Show member pathways
9.0ICAM1, IFNG, IL2, TNF
339.0ICAM1, IL10, TLR2, TNF
34
Show member pathways
8.9IFNG, IL12RB1, IL12RB2
358.9ICAM1, IFNG, IL10, TNF
368.9IFNG, IFNGR1, TLR2, TNF
37
Show member pathways
8.9IFNG, IFNGR1, TLR2, TNF
388.7CD2, IFNG, IL10, IL2, TNF
398.7ICAM1, IFNG, IL10, TLR2, TNF
40
Show member pathways
8.6IFNG, IL12RB1, IL12RB2, IL2
41
Show member pathways
8.6ICAM1, IFNG, IL10, IL2, TNF
42
Show member pathways
8.6IFNG, IFNGR1, IL2, TLR2, TNF
43
Show member pathways
8.6IFNG, IFNGR1, IL10, TLR2, TNF
448.4CD2, IFNG, IL10, IL2, TLR2, TNF
45
Show member pathways
8.3ICAM1, IFNG, IFNGR1, IL2, TNF
46
Show member pathways
8.3IFNG, IL10, IL12RB1, IL2, TNF
47
Show member pathways
8.2IFNG, IFNGR1, IL10, IL2, TLR2, TNF
48
Show member pathways
8.1ICAM1, IFNG, IFNGR1, IL2, TLR2, TNF
498.0IFNG, IFNGR1, IL10, TLR2, TNF, VDR
507.9IFNG, IL10, IL12RB1, IL12RB2, IL2, TNF

GO Terms for genes affiliated with Lepromatous Leprosy

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Cellular components related to Lepromatous Leprosy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.3CD2, ICAM1, IFNG, IL12RB1, IL12RB2, TNF
2integral component of plasma membraneGO:00058877.8CD2, ICAM1, IFNGR1, IL12RB2, TLR2, TNF

Biological processes related to Lepromatous Leprosy according to GeneCards Suite gene sharing:

(show all 43)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-12 productionGO:003273510.6IFNG, TLR2
2defense response to protozoanGO:004283210.6IFNG, IL10
3positive regulation of isotype switching to IgG isotypesGO:004830410.6IFNG, IL2
4positive regulation of chemokine productionGO:003272210.6TLR2, TNF
5positive regulation of MHC class II biosynthetic processGO:004534810.6IFNG, IL10
6positive regulation of interleukin-8 productionGO:003275710.6TLR2, TNF
7positive regulation of NF-kappaB import into nucleusGO:004234610.6TLR2, TNF
8positive regulation of calcidiol 1-monooxygenase activityGO:006055910.6IFNG, TNF
9positive regulation of chemokine biosynthetic processGO:004508010.6IFNG, TNF
10positive regulation of membrane protein ectodomain proteolysisGO:005104410.5IFNG, TNF
11positive regulation of osteoclast differentiationGO:004567210.5IFNG, TNF
12positive regulation of protein complex assemblyGO:003133410.5IFNG, TNF
13endothelial cell apoptotic processGO:007257710.5IL10, TNF
14negative regulation of cytokine secretion involved in immune responseGO:000274010.5IL10, TNF
15negative regulation of interleukin-6 productionGO:003271510.5IL10, TNF
16negative regulation of mitotic cell cycleGO:004593010.5IL10, TNF
17positive regulation of cytokine secretionGO:005071510.5IL10, TNF
18positive regulation of heterotypic cell-cell adhesionGO:003411610.5IL10, TNF
19natural killer cell activationGO:003010110.5CD2, IL2
20positive regulation of vitamin D biosynthetic processGO:006055710.4IFNG, TNF
21protein import into nucleus, translocationGO:000006010.4IFNG, TNF
22positive regulation of vascular smooth muscle cell proliferationGO:190470710.4IL10, TNF
23receptor biosynthetic processGO:003280010.4IL10, TNF
24response to molecule of bacterial originGO:000223710.4IL10, TLR2
25negative regulation of endothelial cell apoptotic processGO:200035210.4ICAM1, IL10
26positive regulation of leukocyte adhesion to vascular endothelial cellGO:190499610.3ICAM1, TNF
27negative regulation of growth of symbiont in hostGO:004413010.2IFNG, IL10, TNF
28positive regulation of protein phosphorylationGO:000193410.2IFNG, IL2, TNF
29regulation of interferon-gamma-mediated signaling pathwayGO:006033410.2IFNG, IFNGR1
30positive regulation of activated T cell proliferationGO:004210410.1IL12RB1, IL2
31positive regulation of tumor necrosis factor productionGO:003276010.1CD2, IFNG, TLR2
32positive regulation of NF-kappaB transcription factor activityGO:005109210.0ICAM1, TLR2, TNF
33positive regulation of nitric oxide biosynthetic processGO:004542910.0ICAM1, IFNG, TNF
34response to insulinGO:00328689.9ICAM1, IL10, TLR2
35interferon-gamma-mediated signaling pathwayGO:00603339.8ICAM1, IFNG, IFNGR1
36negative regulation of cell proliferationGO:00082859.8IFNG, IL10, TLR2, VDR
37positive regulation of gene expressionGO:00106289.7IFNG, TLR2, TNF, VDR
38cellular response to lipopolysaccharideGO:00712229.7ICAM1, IFNG, IL10, TNF
39immune responseGO:00069559.6IFNG, IL10, IL2, TLR2, TNF
40response to lipopolysaccharideGO:00324969.5ICAM1, IL10, IL12RB2, TLR2
41positive regulation of interferon-gamma productionGO:00327299.3IL12RB1, IL12RB2, IL2, TNF
42response to virusGO:00096159.2IFNG, IFNGR1, TNF
43positive regulation of transcription from RNA polymerase II promoterGO:00459449.0IFNG, IL10, IL2, TLR2, TNF, VDR

Molecular functions related to Lepromatous Leprosy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.5IFNG, IL10, IL2, TNF
2cytokine bindingGO:00199559.0IFNGR1, IL12RB1

Sources for Lepromatous Leprosy

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