MCID: LPR001
MIFTS: 50

Lepromatous Leprosy malady

Infectious diseases category

Summaries for Lepromatous Leprosy

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Sources:
9Disease Ontology, 66Wikipedia, 34MalaCards
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Disease Ontology:9 A leprosy that results in early cutaneous lesions which consist of pale macules that are small, diffuse, and symmetric. this form of leprosy is characterized by hypoesthesia over extensor surfaces of the distal extremities, alopecia affecting lateral aspects of the eyebrows, saddle-nose deformity and oral lepromas.

MalaCards: Lepromatous Leprosy, also known as leprosy, lepromatous, is related to leprosy and tuberculosis. An important gene associated with Lepromatous Leprosy is CD2 (CD2 molecule), and among its related pathways are Defensins and Toll Comparative Pathway. The drugs dapsone and clofazimine and the compounds hbd2 and latex have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and monocytes, and related mouse phenotypes are renal/urinary system and immune system.

Wikipedia:66 Lepromatous leprosy is a skin condition consisting of pale macules. more...

Aliases & Classifications for Lepromatous Leprosy

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9Disease Ontology, 46Novoseek, 63UMLS, 36MeSH, 28ICD9CM, 59SNOMED-CT, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

lepromatous leprosy 9
leprosy, lepromatous 63
leprosy lepromatous 46
type l leprosy 9


External Ids:

Disease Ontology9 DOID:10887
MeSH36 D015440
SNOMED-CT59 21560005
ICD9CM28 030.0
ICD1026 A30.5

Related Diseases for Lepromatous Leprosy

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Lepromatous Leprosy:



Diseases related to lepromatous leprosy

Symptoms for Lepromatous Leprosy

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Drugs & Therapeutics for Lepromatous Leprosy

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Lepromatous Leprosy

Drug clinical trials:

Search ClinicalTrials for Lepromatous Leprosy

Search NIH Clinical Center for Lepromatous Leprosy

Search CenterWatch for Lepromatous Leprosy

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Lepromatous Leprosy

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Anatomical Context for Lepromatous Leprosy

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34MalaCards
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MalaCards organs/tissues related to Lepromatous Leprosy:

34
Skin, T cells, Monocytes, Testes, Bone, Spleen, Endothelial, Liver, Tongue, Myeloid, Colon, Heart, Bone marrow, Eye, Lymph node, Kidney, Retina

Animal Models for Lepromatous Leprosy or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Lepromatous Leprosy:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.5IFNGR1, TLR2, DEFB1
2MP:00053877.7IFNGR1, IFNGR2, TLR2, DEFB1

Publications for Lepromatous Leprosy

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53PubMed
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Articles related to Lepromatous Leprosy:

(show top 50)    (show all 503)
idTitleAuthorsYear
1
Lepromatous leprosy treated with combined chemotherapy and immunotherapy (injection BCG): three case reports. (23675902)
2014
2
Borderline lepromatous leprosy with type 1 (downgrading) reaction. (24252148)
2013
3
Deck chair sign in lepromatous leprosy. (24428120)
2013
4
A delayed diagnosis of lepromatous leprosy: pitfalls and clues to early recognition. (22004493)
2011
5
UVB susceptibility as a risk factor to the development of lepromatous leprosy. (21308307)
2010
6
SNP 668C (-44) alters a NF-kappaB1 putative binding site in non-coding strand of human beta-defensin 1 (DEFB1) and is associated with lepromatous leprosy. (19460328)
2009
7
Lepromatous leprosy with erythema nodosum leprosum as immune reconstitution inflammatory syndrome in an HIV-1 infected patient after initiation of antiretroviral therapy. (22132023)
2009
8
Lichen scrofulosorum in a patient with lepromatous leprosy after BCG immunotherapy. (16038252)
2005
9
Histopathological study of apparently normal oral mucosa in lepromatous leprosy. (16375230)
2005
10
Lepromatous leprosy with extensive unusual ulcerations and cachexia. Is it the first case of Lucio's phenomenon from Iran? (15217312)
2004
11
Intra-abdominal, crystal-storing histiocytosis due to clofazimine in a patient with lepromatous leprosy and concurrent carcinoma of the colon. (15282969)
2004
12
Molluscum contagiosum-like lesions in lepromatous leprosy. (15267197)
2003
13
Near-nerve potential in lepromatous leprosy. (14506718)
2003
14
Multicentric reticulohistiocytosis misdiagnosed as lepromatous leprosy. (15267195)
2003
15
Ocular complications in newly diagnosed borderline lepromatous and lepromatous leprosy patients: baseline profile of the Indian cohort. (12446359)
2002
16
Relapse of lepromatous leprosy after WHO/MDT with rapid bacterial growth. (12549846)
2002
17
Localized linear lesions in lepromatous leprosy. (11898466)
2001
18
Cutaneous cryptococcosis associated with lepromatous leprosy. (11589749)
2001
19
Anetoderma secondary to lepromatous leprosy. (11326598)
2001
20
Increased lipid peroxidation in lepromatous leprosy. (20877051)
2000
21
Fine-needle aspiration cytology of lepromatous leprosy. (9715599)
1998
22
Rare transcripts of interferon-gamma detected in lepromatous leprosy cases. (9614846)
1998
23
Diffuse alopecia of the scalp in borderline-lepromatous leprosy in an Indian patient. (9503871)
1997
24
Abnormalities of the sympathetic skin response in lepromatous leprosy. (8808668)
1996
25
Localized borderline lepromatous leprosy. (8537706)
1995
26
Lymphangiographic evaluation of patients with clinical lepromatous leprosy on clofazimine. (8189086)
1994
27
Tongue involvement in lepromatous leprosy. (8425797)
1993
28
Electrocardiographic alterations in lepromatous leprosy patients with concomitant Trypanosoma cruzi infection. (8228450)
1993
29
Loss of viability of Mycobacterium leprae isolated from nasal secretions of lepromatous leprosy patients following daily rifampicin and DDS therapy. (8127217)
1993
30
Lepromatous leprosy: nasal manifestations and treatment with minocycline. (1543336)
1992
31
A histopathological and immunological profile of a single lesion lepromatous leprosy (LLs). (1802946)
1991
32
Vitiligo and lepromatous leprosy. (2030309)
1991
33
Saber tibiae in lepromatous leprosy. (2376687)
1990
34
Histoid lepromas of lepromatous leprosy. (2228377)
1990
35
Single lesion subpolar lepromatous leprosy and its possible mode of origin. (2659697)
1989
36
Mechanisms of Mycobacterium leprae-specific T-cell deficiency in lepromatous leprosy. (3147697)
1988
37
Facies leprosa: resorption of maxillary anterior alveolar bone and the anterior nasal spine in patients with lepromatous leprosy in Mali. (3373085)
1988
38
Estimation of high density lipoprotein cholesterol in the diagnosis of lepromatous leprosy. (3253340)
1988
39
Effect of deoxyfructoserotonin (DFS) on lepromatous leprosy. (2894551)
1988
40
Evidence of cell-mediated immune contrasuppression in lepromatous leprosy: modulation of a putative T contrasuppressor cell-subset. (3133142)
1988
41
Hyperbaric oxygenation (HBO) as a complementary treatment of patients with multibacillary lepromatous leprosy. (3507902)
1987
42
Evaluation of anti-cardiolipin antibody and its cross-reactivity in sera of patients with lepromatous leprosy. (3740940)
1986
43
Failure of specific antigen presentation in lepromatous leprosy. (3702586)
1986
44
Lepromatous leprosy: follow-up rate in 84 patients. (3784759)
1986
45
Lepromatous leprosy: study of some subpopulations of lymphocytes and their functional analysis. (2934039)
1985
46
Detection of phenolic glycolipid I in sera from patients with lepromatous leprosy. (3900237)
1985
47
Preliminary evidence of natural resistance to Mycobacterium bovis (BCG) in lepromatous leprosy. (6373625)
1984
48
Defective production of monocyte-activating cytokines in lepromatous leprosy. (6366107)
1984
49
Mononeuritis multiplex in lepromatous leprosy. (5690422)
1968
50
Mononeuritis multiplex in lepromatous leprosy. (4301578)
1968

Variations for Lepromatous Leprosy

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Expression for genes affiliated with Lepromatous Leprosy

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lepromatous Leprosy

Search GEO for disease gene expression data for Lepromatous Leprosy.

Pathways for genes affiliated with Lepromatous Leprosy

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Sources:
51PathCards, 56Reactome, 54QIAGEN, 61Thomson Reuters, 39NCBI BioSystems Database, 31KEGG, 55R&D Systems
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Pathways related to Lepromatous Leprosy according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3TLR2, DEFB1
2
Show member pathways
Immune response MIF in innate immunity response61
9.1IFNGR1, IFNGR2
39.1IFNGR1, IFNGR2
4
Show member pathways
IFN-gamma pathway39
9.1IFNGR1, IFNGR2
59.1IFNGR2, IFNGR1
69.1IFNGR1, IFNGR2
7
Show member pathways
9.1IFNGR2, IFNGR1
8
Show member pathways
Immune response CD16 signaling in NK cells61
9.1IFNGR1, IFNGR2
9
Show member pathways
Type III interferon signaling39
9.1IFNGR2, IFNGR1
10
Show member pathways
9.1IFNGR2, IFNGR1
119.1IFNGR2, IFNGR1
129.1IFNGR2, IFNGR1
13
Show member pathways
9.1IFNGR1, IFNGR2
14
Show member pathways
8.7IFNGR1, CD2, IFNGR2
15
Show member pathways
8.7IFNGR2, CD2, IFNGR1
16
Show member pathways
IL27-mediated signaling events39
8.5IFNGR2, TLR2, IFNGR1
178.5IFNGR2, IFNGR1, TLR2
18
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
8.5IFNGR1, IFNGR2, TLR2
198.5IFNGR1, IFNGR2, TLR2
20
Show member pathways
8.5TLR2, IFNGR1, IFNGR2
21
Show member pathways
8.5TLR2, IFNGR1, IFNGR2
22
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
8.5IFNGR1, TLR2, IFNGR2
23
Show member pathways
8.5TLR2, IFNGR2, IFNGR1

Compounds for genes affiliated with Lepromatous Leprosy

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46Novoseek, 25HMDB
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Compounds related to Lepromatous Leprosy according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1hbd2469.5TLR2, DEFB1
2latex469.5CD2, TLR2
3polymyxin b469.4TLR2, DEFB1
4ionomycin469.4CD2, TLR2
5heparan sulfate46 2510.0TLR2, DEFB1
6retinoic acid46 259.8DEFB1, TLR2, IFNGR2
7glucose468.8CD2, TLR2, DEFB1

GO Terms for genes affiliated with Lepromatous Leprosy

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17Gene Ontology
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Cellular components related to Lepromatous Leprosy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.1CD2, TLR2
2plasma membraneGO:0058868.1TLR2, IFNGR2, IFNGR1, CD2
3integral component of plasma membraneGO:0058878.0IFNGR1, TLR2, IFNGR2, CD2

Biological processes related to Lepromatous Leprosy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surface receptor signaling pathwayGO:0071669.5CD2, IFNGR2
2positive regulation of tumor necrosis factor productionGO:0327609.4CD2, TLR2
3regulation of interferon-gamma-mediated signaling pathwayGO:0603349.2IFNGR1, IFNGR2
4interferon-gamma-mediated signaling pathwayGO:0603339.0IFNGR2, IFNGR1
5response to virusGO:0096158.8IFNGR1, IFNGR2

Molecular functions related to Lepromatous Leprosy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interferon-gamma receptor activityGO:0049069.1IFNGR1, IFNGR2

Products for genes affiliated with Lepromatous Leprosy

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lepromatous Leprosy

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet