MCID: LPR003
MIFTS: 78

Leprosy malady

Infectious diseases, Neuronal diseases categories

Summaries for Leprosy

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Sources:
8Disease Ontology, 3CDC, 63Wikipedia, 46OMIM, 32MalaCards
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Disease Ontology:8 A primary bacterial infectious disease that results in infection located in superficial peripheral nerves, located in skin, located in mucous membranes of the upper respiratory tract, located in anterior chamber of the eyes, or located in testes, has material basis in mycobacterium leprae, which is transmitted by aerosol spread from infected nasal secretions to exposed nasal and oral mucosa. the infection has symptom skin lesions, has symptom sensory loss, has symptom motor loss and has symptom eye damage.

MalaCards: Leprosy, also known as leprosy, susceptibility to, is related to lepromatous leprosy and tuberculoid leprosy, and has symptoms including eye damage, motor loss and sensory loss. An important gene associated with Leprosy is TLR2 (toll-like receptor 2), and among its related pathways are Akt Signaling and IL27-mediated signaling events. The drug thalidomide and the compounds ionomycin and il 10 have been mentioned in the context of this disorder. Affiliated tissues include anterior chamber of the eyes, mucous membranes of the upper respiratory tract and superficial peripheral nerves, and related mouse phenotypes are immune system and hematopoietic system.

CDC:3 Hansen's disease (also known as leprosy) is a long-lasting infection caused by bacteria.

Wikipedia:63 Leprosy, also known as Hansen\'s disease (HD), is a chronic infection caused by the bacteria... more...

Description from OMIM:46 246300, 607572, 609888, 610988, 613223 613407 more

Aliases & Classifications for Leprosy

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Sources:
8Disease Ontology, 46OMIM, 10DISEASES, 48Orphanet, 60UMLS, 9diseasecard, 27ICD9CM, 39NCIt, 56SNOMED-CT, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

leprosy 8 46 10 48 60
leprosy, susceptibility to 9


External Ids:

Disease Ontology8 DOID:1024
ICD9CM27 030.9, 030
NCIt39 C84824
MeSH34 D007918
MESH via Orphanet35 D007918
ICD10 via Orphanet26 A30.0, A30.1, A30.2 A30.3, A30.4, A30.5, A30.8, A30.9, more
SNOMED-CT via Orphanet57 81004002
UMLS via Orphanet61 C0023343
ICD1025 A30, A30.9

Related Diseases for Leprosy

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Leprosy family:

Leprosy 5 Leprosy 4

Diseases related to Leprosy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 322)
idRelated DiseaseScoreTop Affiliating Genes
1lepromatous leprosy31.7TLR2, IFNG, LTA, IL10, IL4, IL2
2tuberculoid leprosy31.5IL10, IL2RA, IFNG
3tuberculosis30.7SLC11A1, IL2, IL4, TLR2, TLR1, IFNGR2
4leishmaniasis30.4IFNG, IFNGR1, IL10, IL4, SLC11A1
5hepatitis30.4LTA, TLR2
6sarcoidosis30.4IL12RB1, IL2, SLC11A1, IL12B, IL12RB2, IFNGR2
7pulmonary tuberculosis30.3IL10, IL12B, IL12RB1, IL4, IL2, SLC11A1
8malaria30.2TLR2, IFNG, IFNGR1, TNF, CD2, IL10
9arthritis30.2TLR2, IFNG, TNF, LTA, IL10, IL4
10tetanus30.2TLR2, IFNG, LTA, IL2RA, IL10, IL4
11psoriasis30.1TLR2, IFNG, TNF, LTA, IL2RA, IL10
12cutaneous leishmaniasis30.1IFNG, IL10
13systemic lupus erythematosus30.0TLR2, IFNG, IFNGR1, TNF, LTA, CD2
14hepatitis c30.0TLR2, IFNG, TNF, IL10, IL12B, IL4
15hepatitis b30.0TLR2, IFNG, IL2RA, IL10, IL12B
16filariasis30.0TLR2
17rheumatoid arthritis29.9TLR2, PARK2, SLC11A1, IL2, IL4, IL12RB1
18uveitis29.9IL4, IL10, IL2RA, LTA, TNF, IFNG
19dermatitis29.9IFNG, IL4
20mycosis fungoides29.9IL2, IL2RA
21crohn's disease29.9TNF
22rhinitis29.9IL4
23vasculitis29.9TNF
24leukemia29.7TLR2, IFNG, TNF, LTA, CD2, IL2RA
25myasthenia gravis29.7IFNG, LTA, IL10, IL4, IL2
26connective tissue disease29.7TNF, IL2RA, IL10, IL4, IL2
27melanoma29.7IFNG, TNF, CD2, IL10, IL4, IL2
28skin disease29.7TLR2, IFNG, TNF, IL10, IL4
29breast cancer29.7IFNGR2, IFNGR1, IL2, PARK2
30periapical granuloma29.7IL4, IL2RA
31myeloid leukemia29.7LTA
32peritonitis29.7TLR2, TNF
33osteomyelitis29.7IFNGR1
34paracoccidioidomycosis29.7IL10
35alopecia areata29.7IFNG
36myocarditis29.7IL12RB1
37parkinson's disease29.7PACRG, PARK2
38optic neuritis29.7LTA
39acquired immunodeficiency syndrome29.7IL2
40anaplastic large cell lymphoma29.7IL2RA
41sarcoma29.7IL2
42thymoma29.7IL2, CD2
43dementia29.7PARK2
44borderline leprosy10.9
45indeterminate leprosy10.6
46lagophthalmos10.4
47neuropathy10.4
48neuritis10.3
49syphilis10.2
50molluscum contagiosum10.2

Graphical network of the top 20 diseases related to Leprosy:



Diseases related to leprosy

Clinical Features for Leprosy

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Sources:
46OMIM, 8Disease Ontology
See all sources

Clinical features from OMIM:

246300,607572,609888,610988,613223,613407

Clinical synopsis from OMIM:

246300

Symptoms:

8
  • eye damage
  • motor loss
  • sensory loss
  • skin lesions

Drugs & Therapeutics for Leprosy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Leprosy

Drug clinical trials:

Search ClinicalTrials for Leprosy

Search NIH Clinical Center for Leprosy

Search CenterWatch for Leprosy

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Leprosy

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Anatomical Context for Leprosy

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32MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Leprosy:

32
Skin, Eye, T cells, Testes, Bone, Monocytes, Bone marrow, Lymph node, Whole blood, Endothelial, Liver, Myeloid, Breast, Heart, Spleen, Kidney, Tongue, Pituitary, Retina, Colon, Nk cells, Appendix, Olfactory bulb

FMA organs/tissues related to Leprosy:

14
Anterior chamber of the eyes, Mucous membranes of the upper respiratory tract, Superficial peripheral nerves, Skin, Testes

Animal Models for Leprosy or affiliated genes

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Sources:
36MGI
See all sources

Publications for Leprosy

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50PubMed
See all sources

Articles related to Leprosy:

(show top 50)    (show all 1642)
idTitleAuthorsYear
1
Clinical, bacteriological, and histopathological characteristics of newly detected children with leprosy: a population based study in a defined rural and urban area of Maharashtra, Western India. (23760321)
2013
2
Primary multidrug-resistant leprosy, United States. (23260417)
2013
3
Evaluation of agreement between clinical and histopathological data for classifying leprosy. (23158973)
2013
4
Whole-blood nested-PCR amplification of M. leprae-specific DNA for early diagnosis of leprosy. (23478578)
2013
5
Enhancing counselling strategies for leprosy patients through the participation scale. (24428114)
2013
6
Mapping of PARK2 and PACRG overlapping regulatory region reveals LD structure and functional variants in association with leprosy in unrelated indian population groups. (23861666)
2013
7
Detection of previously undetected leprosy cases in Firozabad District (U.P.), India during 2006-2009: a short communication. (24171237)
2013
8
Use of fine needle aspirate from peripheral nerves of pure-neural leprosy for cytology and PCR to confirm the diagnosis: a pilot study. (24177611)
2013
9
A clinical and histopathological study of histoid leprosy. (23590373)
2013
10
Leprosy and its dental management guidelines. (23550518)
2013
11
Clinical and histopathological evaluation of the effect of addition of immunotherapy with Mw vaccine to standard chemotherapy in borderline leprosy. (23720894)
2012
12
Fleshy asymptomatic cutaneous nodules in a young adult male. Histoid leprosy (HL). (22911199)
2012
13
Brazilian clinical trial of uniform multidrug therapy for leprosy patients: the correlation between clinical disease types and adverse effects. (23283457)
2012
14
Unveiling healthy carriers and subclinical infections among household contacts of leprosy patients who play potential roles in the disease chain of transmission. (23283454)
2012
15
Leprosy patients: neurotrophic factors and axonal markers in skin lesions. (22510739)
2012
16
The inclusivity of exclusion: isolation and community among leprosy-affected people in the South Pacific. (22329260)
2011
17
A preliminary study of locognosia in people affected by leprosy. (22783755)
2011
18
Post-traumatic inoculation tuberculoid leprosy after injury with a glass bangle. (19743627)
2009
19
Three patients in a Chinese family with hereditary sensory neuropathy mimicking leprosy. (19274992)
2008
20
Novel HLA Class I Alleles Associated with Indian Leprosy Patients. (12975536)
2003
21
A polymorphism in the toll-like receptor 2 is associated with IL-12 production from monocyte in lepromatous leprosy. (12445799)
2002
22
Genetics of susceptibility to leprosy. (12486602)
2002
23
Association and linkage of leprosy phenotypes with HLA class II and tumour necrosis factor genes. (11477474)
2001
24
Actinomycotic mycetoma due to Nocardia brasiliensis in a case of leprosy. (11840598)
2001
25
Smear positive leprosy with HIV infection, silent neuritis and extensive tinea corporis and tinea unguium in an Indian male. (11898467)
2001
26
Tetanus in a patient with lepromatous leprosy. (11579652)
2001
27
Immunotherapy of lepromin-negative borderline leprosy patients with low-dose Convit vaccine as an adjunct to multidrug therapy; a six-year follow-up study in Calcutta. (9207754)
1997
28
Cytokine profile of circulating T cells of leprosy patients reflects both indiscriminate and polarized T-helper subsets: T-helper phenotype is stable and uninfluenced by related antigens of Mycobacterium leprae. (7590888)
1995
29
An evaluation of the S-100 stain in the histological diagnosis of tuberculoid leprosy and other granulomatous dermatoses. (8046265)
1994
30
Localized lepromatous leprosy and its response to chemo-immunotherapy. (8112948)
1994
31
Mycobacterium leprae DNA content, cellular and cytokine patterns in skin lesions of leprosy patients undergoing multidrug therapy (MDT). (7713552)
1994
32
Comment: 'Results of surgical procedures for the correction of foot-drop and of lagophthalmus due to leprosy'. (8231612)
1993
33
An RFLP map for 2q33-q37 from multicase mycobacterial and leishmanial disease families: no evidence for an Lsh/Ity/Bcg gene homologue influencing susceptibility to leprosy. (7910002)
1993
34
Lymphocyte proliferation, IFN-gamma production and limiting dilution analysis of T-cell responses to ICRC and Mycobacterium leprae antigens in leprosy patients. (8326181)
1993
35
Lepromatous leprosy: nasal manifestations and treatment with minocycline. (1543336)
1992
36
Positive Mitsuda lepromin reactions in long-term treated lepromatous leprosy. (2280656)
1990
37
Late onset of a reversal reaction in borderline leprosy. (2654221)
1989
38
Renal granuloma and mesangial proliferative glomerulonephritis in leprosy. (3221115)
1988
39
Deficiency in the biosynthesis of interleukin 2 (IL-2) and functional presence of the IL-2 receptor in lepromatous leprosy. (3116127)
1987
40
Myelinated and unmyelinated fibers in sural nerve biopsy of a case with lepromatous leprosy--a quantitative approach. (3598284)
1987
41
Lepromatous leprosy: follow-up rate in 84 patients. (3784759)
1986
42
Lymphocyte transformation in lepromatous leprosy: a study of the influence of disease activity and symptom duration. (3738597)
1986
43
Cell mediated immunity in tuberculoid leprosy--a study of 'T' lymphocyte population by 'E' rosetty technique. (3494677)
1986
44
Oral zinc as an adjunct to dapsone in lepromatous leprosy. (6541200)
1984
45
Tuberculoid leprosy vs. tuberculosis of skin. A histopathologic study. (7338397)
1981
46
Variation of in vitro lymphocyte responses to M. leprae antigen in borderline tuberculoid leprosy patients. (6154019)
1980
47
Study on the distribution of single initial lesion of tuberculoid leprosy. (1234873)
1975
48
An indigenous drug in the treatment of acute iridocyclitis in leprosy patients: a study in 13 patients. (4677506)
1972
49
Early tuberculoid leprosy. (5915649)
1966
50
Leprosy lesions of internal viscera with special reference to the lesions of borderline leprosy and lepromatous reaction. (14008517)
1962

Genetic Variations for Leprosy

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Expression for genes affiliated with Leprosy

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Leprosy

Search GEO for disease gene expression data for Leprosy.

Pathways for genes affiliated with Leprosy

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Sources:
51QIAGEN, 37NCBI BioSystems Database, 52R&D Systems, 29KEGG, 53Reactome, 12EMD Millipore, 55SinoBiological, 59Tocris Bioscience
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Pathways related to Leprosy according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.1IL12B, IL2, IL4, IL12RB1, IL10, IL12RB2
2
Hide members
11.1TLR2, IL12RB1, TLR1, IFNGR2, IFNG, IL2
3
Hide members
11.1IL4, IL12RB1, IL12B, IL10, LTA, TNF
4
Hide members
11.0IFNGR2, TLR2, IL2, IL12B, TNF, IFNG
511.0IFNGR2, IL12RB1, IL4, IL2, IFNG, IFNGR1
6
Hide members
11.0IL2RA, TLR1, IL2, TNF, IFNG, IFNGR1
7
Hide members
11.0IFNGR1, TLR2, IL2, IL10, TNF, IFNG
810.9IL12B, IFNGR1, TLR2, TLR1, IL10, TNF
9
Hide members
10.9DEFB1, IFNGR2, TLR1, IL2RA, IFNG, TLR2
1010.9IFNG, TNF, LTA, IL10, IL12B, IL4
11
Hide members
10.9IL12RB2, IL2RA, IL2, IL4, IL12RB1, IL12B
12
Hide members
10.9IL12B, IL2, IL12RB1, IL12RB2, IL2RA, CD2
13
Immune response Bacterial infections in normal airways
10.8IFNGR2, IFNG, IFNGR1, TLR2, TNF, TLR1
1410.8TLR2, TLR1, IFNGR2, IFNG, TNF, IFNGR1
15
Hide members
10.8IL12RB2, IL2RA, CD2, LTA, IL12B, IL12RB1
16
Development PDGF signaling via STATs and NF-kB
Hide members
10.8TNF, IL12RB1, IL2, IFNG, IL10, IL12B
17
Hide members
10.8TLR2, IFNGR2, IFNGR1, IL12RB2, IL12B, IL12RB1
18
Hide members
10.8TNF, IL4, IFNGR1, IFNG, IFNGR2, IL2
19
Hide members
10.8IL12RB1, IL12RB2, IL2RA, CD2, IFNGR1, IFNGR2
20
Hide members
10.8TLR2, TLR1, TNF, LTA, IL12B
2110.8LTA, IL10, IL2, IFNG, IL4
2210.8IL12B, TLR2, IFNG, IL10, TNF
23
Hide members
10.8IL4, LTA, TNF, IL2, IL2RA
24
Hide members
10.8IL2, IL10, IL2RA, TNF, IFNG
25
Hide members
10.7IL2, IL4, IL2RA, TNF, IFNG
26
Hide members
10.7IL12RB1, IL12B, IL12RB2, CD2, LTA
2710.7IL12RB2, IL12RB1, IL2RA, IFNG, IL12B
2810.7IL2, IL12RB1, IL12B, IL2RA, IL12RB2
29
Hide members
10.7IFNGR2, IFNG, IFNGR1, TNF, LTA
30
Hide members
10.7IL2, IFNGR2, IFNG, IFNGR1, IL2RA
31
Hide members
10.7TLR2, TLR1, TNF, LTA
32
Hide members
10.7TLR2, TLR1, TNF, LTA
33
Hide members
10.7TLR2, TLR1, IL2RA, IL2
34
Hide members
10.7IL2RA, IL4, IL2, LTA
3510.7TLR2, TNF, IL12B, IFNG
3610.7IFNG, IL2RA, IL4, IL2
37
Hide members
10.7TNF, IFNG, IFNGR1, LTA
3810.7IL2, IL2RA, TNF, IFNG
3910.7IL10, IL12B, TNF, IFNG
4010.7CD2, TNF, IL2RA, IL4
41
Hide members
10.7IFNGR2, IFNG, IFNGR1, TNF
4210.7TNF, IFNGR2, IFNG, IFNGR1
43
Hide members
10.6IFNG, IL2, IL4
4410.6IFNG, IL2, IL2RA
4510.6IL2, TNF, IFNG
4610.6TNF, IL4, IL2
4710.6IFNGR1, IFNG, IFNGR2
48
Hide members
10.6TLR1, IL12RB1
4910.5TLR2
5010.5IL12B

Compounds for genes affiliated with Leprosy

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Sources:
44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB
See all sources

Compounds related to Leprosy according to GeneCards/GeneDecks:

(show top 50)    (show all 96)
idCompoundScoreTop Affiliating Genes
1ionomycin4411.5LTA, CD2, IL2RA, IL10, IL12RB1, IL4
2il 104411.4LTA, TNF, IFNG, IL2, IL4, IL12B
3rantes4411.4TNF, TLR2, IFNG, LTA, IL12B, IL4
4calcitriol44 59 11 2414.3LTA, TLR2, IL2, IFNG, IL4, IL10
5okt34411.3IL2, IL4, IL10, IFNG, IL2RA, LTA
6il-124411.3IL10, IL4, IL2, IL12RB1, IL12B, TNF
7polyinosinic-polycytidylic acid4411.3IL12B, IFNG, TLR2, IL4, IL2, TNF
8neopterin4411.3LTA, IFNG, IL2, IL4, TNF, IL2RA
9tacrolimus44 49 1113.3IL2RA, IL2, IL4, IL10, TNF, IFNG
10imiquimod44 28 59 1114.2TLR2, TLR1, TNF, IL12B, IL10, IFNG
11polymyxin b4411.2IL10, DEFB1, TNF, IFNG, IL4, TLR2
12lipoteichoic acid4411.2TLR2, TNF, LTA, IL10, IL12B, TLR1
13con a4411.2IL4, IL2, IL10, IFNG, CD2, IL2RA
14infliximab44 49 1113.2LTA, IL2RA, IL10, IFNG, IL4, TNF
15interferon gamma4411.2TNF, IFNG, IL10, IL4, IL2
16histamine44 28 2413.2IL10, IL2, IL2RA, TNF, IFNG, TLR2
17vegf4411.2IL10, TLR2, TNF, PARK2, IL2RA, LTA
18herbimycin a44 5912.1TNF, IL2, IL4, IL2RA, LTA, IFNG
192,5-oligoadenylate4411.1TNF, IL2, IL2RA, IFNG, IL10
20nitric oxide44 11 2413.1PARK2, IFNG, LTA, IL10, IL12B, SLC11A1
21poly(i-c)4411.1IFNG, TLR2, TNF, IL12B, IL4
22peptidoglycan44 2812.1TLR2, TLR1, TNF, IL10, IL12B
23cyclosporin a44 28 5913.1IL2RA, IFNG, LTA, CD2
24thymidine44 2412.1IL2, IL4, IL10, TNF, IFNG, IL2RA
25pentoxifylline44 1112.1IL4, LTA, IL12B
26alpha-galactosylceramide4411.1IFNG, IL10, IL2, IL4
27ifn-alpha4411.1IFNG, PARK2, IL2RA, IL10, IL2
28toxin-14411.1TNF, IL2, LTA, IL10
29dexamethasone44 49 28 1114.0TLR2, LTA, DEFB1
30gold sodium thiomalate4411.0IFNG, TNF, IL2RA, IL2
31glatiramer acetate44 1112.0IL2, IL10, IFNG, IL4
32gm-csf44 2812.0IL10, TNF, IFNG
33thalidomide44 49 59 1114.0IL2, IFNG, IL2RA, IL10, TNF
34sb 20358044 5912.0IL4, IL12B, TNF, IFNG, TLR2, IL10
35tyrosine4411.0IL4, IL2, LTA, PARK2, IL12RB1, IL2RA
36chloroquine44 2 49 28 1115.0TNF, IL2RA, IL10, IL4, IL2
37natalizumab44 1112.0IL10, IL2RA, TNF, IFNG
38vitamin d4411.0LTA, IL10, SLC11A1, IL2RA, TLR2, IL12B
395 aminosalicylic acid4411.0IL10, IL2RA, TNF, IL12B
40prednisolone44 28 1113.0LTA, IL2RA
41ivig4410.9IFNG
42pge24410.9IL2
43betaseron4410.9IL10, IFNG, IL4
44cycloheximide4410.9TLR2, LTA
45etanercept44 49 1112.8TNF, LTA, IL10, IFNG
46simvastatin44 49 59 28 11 2415.8TLR2, IFNG, TNF, IL10, IL4
47mycophenolate mofetil44 49 1112.8IL2, IL10, IL2RA, IFNG
48ribavirin44 49 1112.7IL2, IL4, IFNG, IL10
49c-d4t4410.5IL2, IL2RA, IL4
50tarc4410.4IL4, IFNG, TNF, IL10

GO Terms for genes affiliated with Leprosy

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Sources:
16Gene Ontology
See all sources

Cellular components related to Leprosy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.9IL4, TLR2, IFNG, TNF, CD2, IL2RA
2integral to plasma membraneGO:00588710.8TLR2, TLR1, IFNGR2, IFNGR1, TNF, CD2
3Toll-like receptor 1-Toll-like receptor 2 protein complexGO:03535410.6TLR1, TLR2
4extracellular spaceGO:00561510.6IFNG, TNF, LTA, IL10, IL12B, IL4

Biological processes related to Leprosy according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interferon-gamma productionGO:03272911.3IL12B, LTA, IL12RB2, IL2, IL12RB1, SLC11A1
2positive regulation of transcription from RNA polymerase II promoterGO:04594411.3IL4, IL10, TNF, IFNG, TLR2, SLC11A1
3negative regulation of growth of symbiont in hostGO:04413011.3IFNG, TNF, IL10, LTA, IL12B, TLR2
4immune responseGO:00695511.2IL4, IL2, IL2RA, DEFB1, TLR2, TLR1
5positive regulation of activated T cell proliferationGO:04210411.2IL2, IL4, IL12RB1, IL12B, IL2RA
6cell surface receptor signaling pathwayGO:00716611.2IL2RA, CD2, IL12RB2, IFNGR2, IFNG
7cytokine-mediated signaling pathwayGO:01922111.2IFNGR2, IL12RB1, IFNG, IFNGR1, IL12RB2
8defense response to protozoanGO:04283211.1IL4, SLC11A1, IFNG, IL12B
9response to drugGO:04249311.1IL10, IL4, IFNG, TNF, LTA
10inflammatory responseGO:00695411.1TLR2, IL10, TNF, TLR1, SLC11A1
11defense response to bacteriumGO:04274211.1IL10, DEFB1, IFNG, SLC11A1
12positive regulation of isotype switching to IgG isotypesGO:04830411.1IL2, IL4, IFNG
13positive regulation of MHC class II biosynthetic processGO:04534811.1IL4, IL10, IFNG
14negative regulation of interleukin-17 productionGO:03270011.1TLR2, IFNG, IL12B
15positive regulation of chemokine biosynthetic processGO:04508011.1TNF, IL4, IFNG
16apoptotic processGO:00691511.1TNF, CD2, IFNG, IL2RA, LTA, TLR2
17positive regulation of T-helper 1 type immune responseGO:00282711.1IL12B, IL12RB1, SLC11A1
18positive regulation of osteoclast differentiationGO:04567211.1IFNG, IL12B, TNF
19positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252311.1IL2, IL4, IL12B
20regulation of interferon-gamma-mediated signaling pathwayGO:06033411.1IFNGR2, IFNG, IFNGR1
21natural killer cell activationGO:03010111.1CD2, IL12B, IL2
22positive regulation of NF-kappaB import into nucleusGO:04234611.0TNF, IL12B, TLR2
23protein import into nucleus, translocationGO:00006011.0IFNG, TNF, SLC11A1
24positive regulation of interleukin-12 productionGO:03273511.0TLR2, IL12B, IFNG
25response to virusGO:00961511.0TNF, IFNGR1, IFNGR2, IFNG
26positive regulation of cytokine secretionGO:05071511.0TLR2, IL10, TNF
27positive regulation of nitric oxide biosynthetic processGO:04542911.0TNF, TLR2, IFNG
28positive regulation of tumor necrosis factor productionGO:03276011.0IL12B, IFNG, TLR2
29regulation of T cell homeostatic proliferationGO:04601311.0IL2, IL2RA
30cellular response to triacyl bacterial lipopeptideGO:07172711.0TLR2, TLR1
31positive regulation of vitamin D biosynthetic processGO:06055711.0IFNG, TNF
32positive regulation of chronic inflammatory response to antigenic stimulusGO:00287611.0LTA, TNF
33detection of triacyl bacterial lipopeptideGO:04249510.9TLR1, TLR2
34defense response to Gram-positive bacteriumGO:05083010.9TLR2, TNF, LTA
35regulation of isotype switchingGO:04519110.9IL4, IL10
36humoral immune responseGO:00695910.9LTA, TNF, IFNG
37positive regulation of calcidiol 1-monooxygenase activityGO:06055910.9IFNG, TNF
38detection of diacyl bacterial lipopeptideGO:04249610.9TLR1, TLR2
39receptor biosynthetic processGO:03280010.9TNF, IL10
40positive regulation of T cell proliferationGO:04210210.8IFNG, IL4, IL12B
41positive regulation of inflammatory responseGO:05072910.8IL2, IL12B, TLR2
42positive regulation of T-helper 17 cell lineage commitmentGO:200033010.8IL12RB1, IL12B
43type 2 immune responseGO:04209210.8IL10, IL4
44positive regulation of memory T cell differentiationGO:04338210.7IL12B, IL12RB1
45negative regulation of cytokine secretion involved in immune responseGO:00274010.7TNF, IL10
46positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.7LTA, TNF
47positive regulation of smooth muscle cell apoptotic processGO:03439310.6IL12B, IFNG
48positive regulation of T-helper 17 type immune responseGO:200031810.6IL12B, IL12RB1
49positive regulation of tissue remodelingGO:03410510.5IL2, IL12B
50positive regulation of interleukin-6 biosynthetic processGO:04541010.3IFNG, TLR1

Molecular functions related to Leprosy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.9IL2, IL4, IL12B, IL10, LTA, TNF
2cytokine receptor activityGO:00489610.6IL12RB2, IL12B, IL12RB1
3interleukin-12 receptor bindingGO:00514310.6IL12RB1, IL12B
4interferon-gamma receptor activityGO:00490610.5IFNGR1, IFNGR2
5growth factor activityGO:00808310.4IL2, IL4, IL12B, IL10

Products for genes affiliated with Leprosy

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Leprosy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet