MCID: LPR003
MIFTS: 71

Leprosy malady

Genetic diseases, Infectious diseases, Neuronal diseases, Reproductive diseases, Rare diseases, Skin diseases, Eye diseases categories

Summaries for Leprosy

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Disease Ontology:9 A primary bacterial infectious disease that results in infection located in superficial peripheral nerves, located in skin, located in mucous membranes of the upper respiratory tract, located in anterior chamber of the eyes, or located in testes, has material basis in mycobacterium leprae, which is transmitted by aerosol spread from infected nasal secretions to exposed nasal and oral mucosa. the infection has symptom skin lesions, has symptom sensory loss, has symptom motor loss and has symptom eye damage.

MalaCards based summary: Leprosy, also known as leprosy, susceptibility to, is related to tuberculoid leprosy and lepromatous leprosy, and has symptoms including skin lesions, sensory loss and motor loss. An important gene associated with Leprosy is TLR2 (toll-like receptor 2), and among its related pathways are Defensins and IL2-mediated signaling events. The drug thalidomide and the compounds alpha-galactosylceramide and toxin-1 have been mentioned in the context of this disorder. Affiliated tissues include superficial peripheral nerves, skin and mucous membranes of the upper respiratory tract, and related mouse phenotypes are no phenotypic analysis and renal/urinary system.

Wikipedia:63 Leprosy /?l?pr?si/, also known as Hansen\'s disease (HD), is a chronic infection caused by the bacteria... more...

Descriptions from OMIM:45 246300,607572

Aliases & Classifications for Leprosy

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Sources:
45OMIM, 9Disease Ontology, 11DISEASES, 47Orphanet, 3CDC, 60UMLS, 10diseasecard, 22GTR, 55SNOMED-CT, 27ICD9CM, 38NCIt, 33MeSH, 26ICD10 via Orphanet, 61UMLS via Orphanet, 34MESH via Orphanet, 25ICD10
See all sources

Leprosy, Aliases & Descriptions:

Name: Leprosy 45 9 11 47 3 60
Leprosy, Susceptibility to 10
 
Leprosy 2 22


Classifications:



Characteristics (Orphanet epidemiological data):

47
leprosy:
Inheritance: Multigenic/multifactorial; Prevalence: 1-9/100000 (Worldwide); Age of onset: All ages; Age of death: any age


External Ids:

Disease Ontology9 DOID:1024
ICD9CM27 030.9, 030
NCIt38 C84824
MeSH33 D007918
Orphanet47 548
ICD10 via Orphanet26 A30.3, A30.4, A30.5 A30.8, A30.9, A30.0, A30.1, A30.2, more
UMLS via Orphanet61 C0023343
MESH via Orphanet34 D007918
ICD1025 A30, A30.9

Related Diseases for Leprosy

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Diseases in the Leprosy family:

Leprosy 5 Leprosy 4

Diseases related to Leprosy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 276)
idRelated DiseaseScoreTop Affiliating Genes
1tuberculoid leprosy32.0IL10, IL2RA, IFNG
2lepromatous leprosy31.8LTA, IL10, TLR2, IFNG, IL4, IL2
3filariasis30.8TLR2
4cutaneous leishmaniasis30.7IL10, IFNG
5aspergillosis30.4IFNG, TLR2
6periapical granuloma30.3IL2RA, IL4
7malaria30.3IL10, IL12B, IFNG, TNF
8leishmaniasis30.3SLC11A1, IL10, IL4, IFNGR1, IFNG
9hepatitis c30.2IL10, TLR2, IL12B, IFNG
10arthritis30.1IL10, LTA, SLC11A1, TLR2, TNF, IFNG
11hepatitis b30.0IL12B, TLR2, IL2RA, IL10, IFNG
12tetanus30.0LTA, IL10, IL2, IL4, IFNG, TLR2
13myasthenia gravis29.9LTA, IFNG, IL10, IL2, IL4
14uveitis29.8TNF, IL4, IL2RA, IL10, LTA, IFNG
15connective tissue disease29.7IL2RA, IL4, IL10, TNF, IL2
16atopy29.6IL12B, SLC11A1, LTA, IL4, IL10, IL12RB2
17melanoma29.4CD2, IL2, IL10, IFNG, IL4, TNF
18tuberculosis29.3IFNGR1, TNF, TLR1, TLR2, IFNG, IL4
19pulmonary tuberculosis29.2SLC11A1, IL12B, IL10, IL2RA, IL2, IL4
20colitis29.0IL4, DEFB1, TLR2, IL12RB2, IL12B, IL10
21psoriasis29.0IL10, IL12B, KRT10, LTA, IL2RA, IL2
22ulcerative colitis28.7DEFB1, TLR2, TNF, IFNG, IL4, IL2RA
23rheumatoid arthritis28.7IFNG, PARK2, TLR2, LTA, IL10, IL12B
24systemic lupus erythematosus28.6IFNG, IL4, IL2, IL2RA, IL10, IL12B
25leukemia28.1IL2RA, KRT10, IL12B, IL2, IL4, IFNG
26borderline leprosy10.8
27indeterminate leprosy10.7
28hansen's disease10.7
29periodontitis10.5TLR2
30farmer's lung10.5IL2RA
31tularemia10.5TLR2
32lagophthalmos10.5
33intraocular lymphoma10.5IL10
34neuropathy10.5
35foot drop10.5
36tonsillitis10.4LTA
37blau syndrome10.4TNF
38hyper-ige recurrent infection syndrome10.4IL4, IFNG
39pleurisy10.3IL2RA
40skin disease10.3IL2, IL2RA
41alcoholic hepatitis10.3IL10, TNF
42pleural tuberculosis10.3IFNG, IL2RA
43selective iga deficiency disease10.3LTA, IL10, IL4
44leprosy 510.3
45hepatitis10.3
46neuritis10.3
47acne10.3TLR2, DEFB1
48mycobacterium avium complex disease10.3IFNGR1
49agammaglobulinemia10.3IL4, IL2, LTA
50molluscum contagiosum10.3

Graphical network of the top 20 diseases related to Leprosy:



Diseases related to leprosy

Symptoms for Leprosy

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Symptoms by clinical synopsis from OMIM:

246300

Clinical features from OMIM:

246300,607572

Symptoms:

 9
  • skin lesions
  • sensory loss
  • motor loss
  • eye damage

HPO human phenotypes related to Leprosy:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 autosomal recessive inheritance HP:0000007
3 abnormality of the immune system HP:0002715

Drugs & Therapeutics for Leprosy

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Drug clinical trials:

Search ClinicalTrials for Leprosy

Search NIH Clinical Center for Leprosy

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Leprosy

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Genetic tests related to Leprosy:

id Genetic test Affiliating Genes
1 Leprosy 222

Anatomical Context for Leprosy

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MalaCards organs/tissues related to Leprosy:

31
Skin, Eye, T cells, Testes, Bone, Monocytes, Bone marrow, Lymph node, Whole blood, Liver, Myeloid, Endothelial, Spleen, Retina, Spinal cord, Heart, Colon, Kidney, Breast, Nk cells, Olfactory bulb, Tongue, Appendix, Pituitary, Neutrophil

FMA organs/tissues related to Leprosy:

14
Superficial peripheral nerves, Skin, Mucous membranes of the upper respiratory tract, Anterior chamber of the eyes, Testes

Animal Models for Leprosy or affiliated genes

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MGI Mouse Phenotypes related to Leprosy:

35 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.7IL4, TNF, PARK2, IFNG, IL10, IL2
2MP:00053678.3DEFB1, TLR2, IFNGR1, IFNG, IL12RB2, IL4
3MP:00053828.2IL12B, TNF, IL4, IFNG, KRT10, IL10
4MP:00053888.1LTA, IL12B, IL10, IL2, IL4, IFNG
5MP:00036317.8TLR2, LTA, IL10, IL4, IFNG, PARK2
6MP:00053857.8TNF, TLR2, IL12RB2, PARK2, IFNGR1, IFNG
7MP:00053707.8IL10, IL2, IL4, IL12RB2, IFNG, IFNGR1
8MP:00053797.8IL4, LTA, IL10, IL2, IL12RB2, IFNG
9MP:00053867.7IL2, IFNG, IFNGR1, TLR2, TNF, IL10
10MP:00107717.6IL4, TLR2, TNF, PARK2, IFNGR1, IFNG
11MP:00053907.6IFNG, IL4, IL10, LTA, IFNGR1, PARK2
12MP:00053787.5IL2, KRT10, IL2RA, TNF, IL10, LTA
13MP:00053847.4TLR2, IL4, IL2, IFNG, IFNGR1, TNF
14MP:00053767.0IL2, IL10, IFNG, TLR2, TNF, PARK2
15MP:00020066.9SLC11A1, KRT10, TLR2, TNF, IFNGR1, IFNG
16MP:00053816.9IL12RB2, IL2, IL2RA, IL10, IL12B, SLC11A1
17MP:00053976.2IL18RAP, IL2, IL4, IL12RB2, IFNG, IFNGR1
18MP:00107685.6IL10, IL12B, KRT10, LTA, SLC11A1, DEFB1
19MP:00053875.2KRT10, IL12B, IL18RAP, IL2RA, SLC11A1, IL2

Publications for Leprosy

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Articles related to Leprosy:

(show top 50)    (show all 1697)
idTitleAuthorsYear
1
Oral manifestation of lepromatous leprosy: diagnosis and management. (24848267)
2014
2
Borderline lepromatous leprosy with type 1 (downgrading) reaction. (24252148)
2013
3
Interleukin-17F single-nucleotide polymorphism (7488T>C) and its association with susceptibility to leprosy. (24164796)
2013
4
Role of HLA, KIR, MICA, and cytokines genes in leprosy. (23936864)
2013
5
History of infectious diseases development in the Old and the Middle Ages with the emphasis on the plague and leprosy. (23984623)
2013
6
Intolerance to leprosy multi-drug therapy: more common in women? (24428115)
2013
7
Genetic evidence of TAP1 gene variant as a susceptibility factor in Indian leprosy patients. (23395648)
2013
8
Bacterial load in the nose and its correlation to the immune response in leprosy patients. (23741885)
2013
9
The effect of systemic corticosteroid therapy on the expression of toll-like receptor 2 and toll-like receptor 4 in the cutaneous lesions of leprosy Type 1 reactions. (22348338)
2012
10
Identification of serological biomarkers of infection, disease progression and treatment efficacy for leprosy. (23283458)
2012
11
Comparing the clinical and histological diagnosis of leprosy and leprosy reactions in the INFIR cohort of Indian patients with multibacillary leprosy. (22745841)
2012
12
Leprosy among migrant workers: ensuring proper treatment. (23614250)
2012
13
Histopathological examination of nerve samples from pure neural leprosy patients: obtaining maximum information to improve diagnostic efficiency. (22415265)
2012
14
Hansen's disease (Leprosy): current and future pharmacotherapy and treatment of disease-related immunologic reactions. (22392826)
2012
15
Characterization of the profession/occupation of individuals affected by leprosy and the relationship with limitations in professional activities. (23077777)
2012
16
Is there a relation between hemicrania continua and leprosy? (23720896)
2012
17
Chronic rhinitis: a manifestation of leprosy. (21938685)
2011
18
Cytokine and protein markers of leprosy reactions in skin and nerves: baseline results for the North Indian INFIR cohort. (22180790)
2011
19
Leprosy elimination campaign in Qazvin province, Islamic Republic of Iran (2006-07). (22355944)
2011
20
Study of cytokine response against panel of purified Mycobacterium leprae antigens by using whole blood assay in subjects residing in a resettlement village of cured leprosy patients. (21229844)
2010
21
SNP 668C (-44) alters a NF-kappaB1 putative binding site in non-coding strand of human beta-defensin 1 (DEFB1) and is associated with lepromatous leprosy. (19460328)
2009
22
Functional haplotypes that produce normal ficolin-2 levels protect against clinical leprosy. (19434912)
2009
23
A case of recurrent rash and leg numbness mimicking systemic rheumatic disease: the occurrence of leprosy in a nonendemic area. (17551381)
2007
24
Leprosy masquerading as Melkersson-Rosenthal syndrome. (16353526)
2005
25
Tuberculoid leprosy confined to glans penis in two cases. (15282972)
2004
26
Linkage of leprosy susceptibility to Parkinson's disease genes. (15301585)
2004
27
Lepromatous leprosy with extensive unusual ulcerations and cachexia. Is it the first case of Lucio's phenomenon from Iran? (15217312)
2004
28
Molluscum contagiosum-like lesions in lepromatous leprosy. (15267197)
2003
29
Localized linear lesions in lepromatous leprosy. (11898466)
2001
30
Association and linkage of leprosy phenotypes with HLA class II and tumour necrosis factor genes. (11477474)
2001
31
Cutaneous cryptococcosis associated with lepromatous leprosy. (11589749)
2001
32
Lagophthalmos in leprosy. (9598404)
1998
33
The current situation of lagophthalmos and keratopathy of leprosy in PR China. (9598407)
1998
34
Charles Bonnet syndrome in leprosy; prevalence and clinical characteristics. (8712028)
1996
35
Host parasite response in nerve in leprosy. (8727123)
1996
36
Localized borderline lepromatous leprosy. (8537706)
1995
37
Reply: 'Results of surgical procedures for the correction of foot-drop and lagophthalmus due to leprosy'. (7861931)
1994
38
Comment: 'Results of surgical procedures for the correction of foot-drop and of lagophthalmus due to leprosy'. (8231612)
1993
39
Tongue involvement in lepromatous leprosy. (8425797)
1993
40
Electrocardiographic alterations in lepromatous leprosy patients with concomitant Trypanosoma cruzi infection. (8228450)
1993
41
Lepromatous leprosy: nasal manifestations and treatment with minocycline. (1543336)
1992
42
Camptodactyly simulating claw hand in a patient with indeterminate leprosy. (1783793)
1991
43
In vitro effect of interleukin-2 on proliferative responses of peripheral blood T cells from leprosy patients. (1781183)
1991
44
Single lesion subpolar lepromatous leprosy and its possible mode of origin. (2659697)
1989
45
Evaluation of anti-cardiolipin antibody and its cross-reactivity in sera of patients with lepromatous leprosy. (3740940)
1986
46
Should indeterminate leprosy ever be diagnosed? (7195888)
1981
47
Mechanism of nerve destruction in tuberculoid-borderline leprosy. An electron-microscopic study. (4582968)
1973
48
The Kveim test in lepromatous and tuberculoid leprosy. (5394258)
1969
49
Pure neural tuberculoid leprosy. (4283894)
1965
50
ELECTRON MICROSCOPIC STUDY OF BORDERLINE LEPROSY. (14166266)
1963

Variations for Leprosy

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Clinvar genetic disease variations for Leprosy:

6
id Gene Variation Type Significance SNP ID Assembly Location
1TLR2NM_003264.3(TLR2): c.2029C> T (p.Arg677Trp)single nucleotide variantrisk factorrs121917864GRCh37Chr 4, 154626088: 154626088

Expression for genes affiliated with Leprosy

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Search GEO for disease gene expression data for Leprosy.

Pathways for genes affiliated with Leprosy

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Pathways related to Leprosy according to GeneCards Suite gene sharing:

(show top 50)    (show all 60)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6TLR2, TLR1, DEFB1
2
Show member pathways
IL-2 Signaling pathway36
9.5IFNG, IL2, IL2RA
39.5IFNG, IL2, TNF
4
Show member pathways
9.5TNF, TLR1, TLR2, LTA
5
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
9.4IL18RAP, TNF, TLR1, TLR2
69.4TLR2, TNF, IL12B
7
Show member pathways
9.4TLR2, IL2RA, IL2, TLR1
89.4TLR2, IL10, IFNG, TNF
9
Show member pathways
IL2 signaling events mediated by STAT536
9.3IL2, IL4, IL2RA, LTA
109.3IL2, IL2RA, IL18RAP, IFNG
119.2IL2, IL4, IL2RA, IFNG
129.2IL4, IL10, IL2, IL2RA
139.2IFNG, IL2, IL4, TNF
14
Show member pathways
Ras signaling in the CD4+ TCR pathway36
9.2IFNG, IL2RA, TNF, IL2
15
Show member pathways
9.2TNF, LTA, TLR1, TLR2, IL2
169.1IL12B, IL2RA, IL12RB2, IFNG
179.1IFNG, IL12B, TNF, TLR2
189.1LTA, IL10, IL2, IL4, IFNG
19
Show member pathways
Immune response IL 22 signaling pathway58
G protein signaling N RAS regulation pathway58
9.1IL12RB2, IL2, IL2RA, IL12B
209.0CD2, IL2RA, IL4, TNF
219.0IFNG, TNF, IL12B, IL10
22
Show member pathways
9.0IL4, IL12B, IFNG, TLR1, TLR2
23
Show member pathways
9.0LTA, TLR1, TNF, IL12B, TLR2
24
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes58
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway58
8.9TNF, LTA, IL2RA, IL2, IL4
25
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
8.9IL2, IL4, IFNG, IL10, TNF
26
Show member pathways
8.9IL2RA, TNF, IFNG, IL2, IL10
27
Show member pathways
Calcium signaling in the CD4+ TCR pathway36
8.9IL4, IL2RA, TNF, IFNG, IL2
288.8IL10, IFNG, TLR2, TNF, IL12B
29
Show member pathways
8.8IFNGR1, TNF, LTA, IFNG
30
Show member pathways
8.8IFNG, LTA, IFNGR1, TNF
318.6TNF, IFNG, TLR1, IFNGR1, TLR2
32
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway58
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB58
Development Angiopoietin Tie2 signaling58
8.5IFNG, TNF, IL2, IL10, IL12B, IL18RAP
338.4IL4, IL12B, IL10, IL2, TNF, IFNG
34
Show member pathways
Immune response CD16 signaling in NK cells58
8.4IFNG, IL4, IFNGR1, TNF, IL2
35
Show member pathways
Immune response IL 12 induced IFN gamma production58
8.3IL2RA, IL18RAP, IL12B, IL2, IL4, IL12RB2
368.2TNF, IFNG, IL4, IL2, IL10, IL12B
37
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
8.1IL4, IFNG, IFNGR1, TLR2, TLR1, TNF
387.8IL10, IL12B, TNF, IFNG, IFNGR1, TLR1
39
Show member pathways
7.6TLR2, TLR1, IFNGR1, IFNG, IL4, IL2
40
Show member pathways
7.5IL12B, IL10, IL2RA, IL2, IL4, IL12RB2
41
Show member pathways
7.5CD2, LTA, IL4, IL10, IL12B, IL2
42
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
7.5TLR1, IL10, TLR2, IL2, IFNG, IFNGR1
43
Show member pathways
Type III interferon signaling36
7.4IFNG, IL12B, IL10, IL2RA, IL2, IL4
44
Show member pathways
7.1IL12B, IL2RA, IL2, IL4, IFNG, IFNGR1
45
Show member pathways
7.1TLR2, TLR1, TNF, IL12RB2, IL4, IL2
46
Show member pathways
6.9IFNG, IFNGR1, TLR2, IL12RB2, IL4, IL18RAP
47
Show member pathways
6.8TNF, IFNGR1, IFNG, IL12RB2, IL4, IL2
48
Show member pathways
IL27-mediated signaling events36
6.8LTA, IL18RAP, IL12B, IL10, IL2, IL12RB2
49
Show member pathways
6.4IFNGR1, TNF, LTA, IFNG, IL12RB2, IL2
50
Show member pathways
6.2IL4, IL2, IL2RA, IL10, IL12B, IL12RB2

Compounds for genes affiliated with Leprosy

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Compounds related to Leprosy according to GeneCards Suite gene sharing:

(show top 50)    (show all 135)
idCompoundScoreTop Affiliating Genes
1alpha-galactosylceramide439.7IL10, IFNG, IL4, IL2
2toxin-1439.6LTA, IL10, IL2, TNF
3glatiramer acetate43 1210.6IL10, IFNG, IL2, IL4
4betaseron439.5IFNG, IL10, IL4
5natalizumab43 1210.5IL2RA, IFNG, IL10, TNF
6gold sodium thiomalate439.5IFNG, IL2RA, IL2, TNF
7ifn-alpha439.4PARK2, IL2, IL10, IL2RA, IFNG
8interferon gamma439.4TNF, IL2, IL4, IFNG, IL10
9etanercept43 49 1211.3TNF, IFNG, LTA, IL10
10gm-csf43 2810.3IL10, IL2, IL4, IFNG, TNF
112,5-oligoadenylate439.3TNF, IL2, IL2RA, IL10, IFNG
125 aminosalicylic acid439.2IL10, TNF, IL2RA, IL12B
13peptidoglycan43 2810.2IL10, TLR1, TNF, TLR2, IL12B
14poly(i-c)439.2TLR2, IL4, IFNG, IL12B, TNF
15thalidomide43 49 59 1212.1IL10, IL2RA, IL2, IFNG, TNF
16infliximab43 49 1211.1IFNG, LTA, TNF, IL4, IL2RA, IL10
17ivig439.1IFNG, TNF, IL4, IL2RA, IL10, LTA
18chloroquine43 2 49 28 1213.1TNF, IL10, IL2RA, IL2, IL4
19mycophenolate mofetil43 49 1211.1LTA, TNF, IL2RA, IFNG, IL10, IL2
20lipoteichoic acid439.1TNF, IL10, IL12B, TLR1, TLR2, LTA
21prednisolone43 28 1211.1TNF, IFNG, IL2, IL2RA, IL10, LTA
22imiquimod43 59 28 1212.0IL10, IFNG, TNF, TLR1, TLR2, IL12B
23polymyxin b439.0IL10, IL4, IFNG, TNF, TLR2, DEFB1
24herbimycin a43 5910.0LTA, IL2RA, TNF, IL4, IFNG, IL2
25con a439.0IFNG, IL4, CD2, IL10, IL2RA, IL2
26endotoxin439.0LTA, TNF, IFNG, TLR2, IL12B, IL10
27rolipram43 59 2811.0IL4, IL10, TNF, IFNG
28hydrocortisone43 2 59 1211.9IL4, IL10, IFNG, TNF, IL2
29il-12438.8IL2, IL4, IL10, IFNG, IL12B, TNF
30okt3438.8IL10, IL2RA, LTA, TNF, IFNG, IL4
31neopterin438.8TNF, IL4, IL2, IL2RA, IL10, IFNG
32tacrolimus43 49 1210.8IFNG, IL10, IL2RA, IL2, IL4, TLR2
33indomethacin43 28 59 1211.8IL4, TNF, IL2, LTA, IL2RA, IFNG
34histamine43 28 2410.7IL2, IL4, IL2RA, IL10, IFNG, TNF
35polyinosinic-polycytidylic acid438.7IL12B, IL10, IL4, IFNG, TNF, TLR2
36sb 20358043 599.6TNF, IFNG, IL4, IL10, IL12B, TLR2
37vitamin d438.5LTA, IL12B, SLC11A1, KRT10, TLR2, IL2RA
38nitric oxide43 24 1210.4TLR2, TNF, LTA, IL10, SLC11A1, PARK2
39thymidine43 249.4CD2, IL10, IL2RA, IL4, IFNG, IL2
40vegf438.4LTA, IFNG, PARK2, TNF, TLR2, IL2RA
41cycloheximide438.4IL10, TLR2, IL2, TNF, IL4, IL12B
42pentoxifylline43 129.3IL2RA, IL10, IL2, IL12B, IL4, IFNG
43ionomycin438.2LTA, IL10, IL2RA, IL4, IFNG, CD2
44rantes438.2DEFB1, IL4, IL2, IL2RA, IL10, IL12B
45cyclosporin a43 28 5910.2LTA, TLR2, TNF, IFNG, IL4, IL2
46il 10438.1TLR2, TNF, IFNG, IL4, IL2, IL2RA
47pge2438.1TNF, IFNG, IL4, IL2, IL2RA, IL10
48calcitriol43 59 24 1211.0IL2RA, TLR2, KRT10, LTA, IL10, IL2
49dexamethasone43 49 28 1210.5IL2RA, DEFB1, TLR2, TNF, IFNG, IL4
50tyrosine437.0IL4, IFNGR1, TLR2, LTA, CD2, IL12RB2

GO Terms for genes affiliated with Leprosy

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Cellular components related to Leprosy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1Toll-like receptor 1-Toll-like receptor 2 protein complexGO:003535410.0TLR1, TLR2
2external side of plasma membraneGO:00098978.4CD2, IL2RA, IL4, IL12RB2, IFNG, TNF
3integral component of plasma membraneGO:00058877.7TLR2, TLR1, TNF, IFNGR1, IL12RB2, CD2
4extracellular spaceGO:00056157.5TNF, IFNG, IL4, IL2, IL10, IL12B

Biological processes related to Leprosy according to GeneCards Suite gene sharing:

(show top 50)    (show all 62)
idNameGO IDScoreTop Affiliating Genes
1cellular response to triacyl bacterial lipopeptideGO:007172710.4TLR2, TLR1
2detection of triacyl bacterial lipopeptideGO:004249510.4TLR1, TLR2
3positive regulation of chronic inflammatory response to antigenic stimulusGO:000287610.3LTA, TNF
4regulation of isotype switchingGO:004519110.2IL4, IL10
5positive regulation of interleukin-18 productionGO:003274110.2TLR2, TNF
6positive regulation of vitamin D biosynthetic processGO:006055710.2IFNG, TNF
7type 2 immune responseGO:004209210.2IL10, IL4
8regulation of T cell homeostatic proliferationGO:004601310.2IL2, IL2RA
9positive regulation of calcidiol 1-monooxygenase activityGO:006055910.2TNF, IFNG
10positive regulation of interleukin-6 biosynthetic processGO:004541010.1IFNG, TLR1
11receptor biosynthetic processGO:003280010.1IL10, TNF
12positive regulation of humoral immune response mediated by circulating immunoglobulinGO:000292510.1TNF, LTA
13macrophage activationGO:004211610.1TLR1, SLC11A1
14negative regulation of cytokine secretion involved in immune responseGO:000274010.1TNF, IL10
15defense response to Gram-positive bacteriumGO:005083010.1LTA, TNF, TLR2
16positive regulation of MHC class II biosynthetic processGO:004534810.1IL10, IL4, IFNG
17positive regulation of isotype switching to IgG isotypesGO:004830410.0IFNG, IL4, IL2
18positive regulation of nitric oxide biosynthetic processGO:004542910.0TLR2, IFNG, TNF
19positive regulation of cytokine secretionGO:005071510.0TLR2, IL10, TNF
20protein import into nucleus, translocationGO:000006010.0IFNG, TNF, SLC11A1
21positive regulation of chemokine biosynthetic processGO:004508010.0TNF, IFNG, IL4
22positive regulation of tumor necrosis factor biosynthetic processGO:00425359.9TLR2, TLR1
23negative regulation of interleukin-17 productionGO:00327009.9TLR2, IL12B, IFNG
24humoral immune responseGO:00069599.9IFNG, LTA, TNF
25positive regulation of interleukin-12 productionGO:00327359.9IL12B, IFNG, TLR2
26positive regulation of interleukin-10 productionGO:00327339.9TLR2, IL12B, IL4
27positive regulation of tissue remodelingGO:00341059.9IL2, IL12B
28positive regulation of smooth muscle cell apoptotic processGO:00343939.8IFNG, IL12B
29positive regulation of NF-kappaB import into nucleusGO:00423469.8IL12B, TNF, TLR2
30positive regulation of tyrosine phosphorylation of Stat5 proteinGO:00425239.8IL12B, IL2, IL4
31positive regulation of T-helper 1 type immune responseGO:00028279.7SLC11A1, IL12B
32positive regulation of inflammatory responseGO:00507299.7TLR2, IL12B, IL2
33positive regulation of osteoclast differentiationGO:00456729.7IL12B, TNF, IFNG
34positive regulation of T cell proliferationGO:00421029.7IFNG, IL4, IL12B
35defense response to bacteriumGO:00427429.6IL10, DEFB1, SLC11A1, IFNG
36natural killer cell activationGO:00301019.6CD2, IL12B, IL2
37positive regulation of interleukin-17 productionGO:00327409.6IL2, IL12B
38defense response to protozoanGO:00428329.6SLC11A1, IFNG, IL4, IL12B
39positive regulation of tumor necrosis factor productionGO:00327609.5CD2, TLR2, IL12B, IFNG
40cellular response to lipopolysaccharideGO:00712229.5IL12B, IL10, IFNG
41response to drugGO:00424939.4IL4, TNF, IFNG, IL10, LTA
42positive regulation of activated T cell proliferationGO:00421049.4IL2, IL12B, IL2RA, IL4
43cell surface receptor signaling pathwayGO:00071669.4CD2, IL12RB2, IFNG, IL18RAP, IL2RA
44inflammatory responseGO:00069549.4IL18RAP, TLR1, SLC11A1, TNF, TLR2, IL10
45positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.2IL4, IL10, TNF
46negative regulation of growth of symbiont in hostGO:00441309.1TLR2, TNF, IFNG, IL10, IL12B, LTA
47apoptotic processGO:00069159.1LTA, IL2RA, IFNG, TNF, TLR2, CD2
48positive regulation of interferon-gamma productionGO:00327299.1TNF, LTA, SLC11A1, IL12RB2, IL12B, IL2
49positive regulation of transcription from RNA polymerase II promoterGO:00459448.9IFNG, TLR2, TNF, IL2, IL4, SLC11A1
50immune responseGO:00069558.8DEFB1, TLR2, TLR1, IL4, IL2, IL2RA

Molecular functions related to Leprosy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine receptor activityGO:00048969.7IL12B, IL12RB2
2receptor activityGO:00048729.1CD2, IL18RAP, TLR1, TLR2
3growth factor activityGO:00080839.0IL4, IL2, IL10, IL12B
4cytokine activityGO:00051258.2LTA, IL12B, IL10, IL2, IL4, IFNG

Products for genes affiliated with Leprosy

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  • Antibodies
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Sources for Leprosy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet