Leprosy malady

CDC: This chronic infectious disease usually affects the skin and peripheral nerves but has a wide range of possible clinical manifestations. Patients are classified as having paucibacillary or multibacillary Hansen's disease. Paucibacillary Hansen's disease is milder and characterized by one or more hypopigmented skin macules. Multibacillary Hansen's disease is associated with symmetric skin lesions, nodules, plaques, thickened dermis, and frequent involvement of the nasal mucosa resulting in nasal congestion and epistaxis.²

MalaCards: Leprosy is related to lepromatous leprosy and tuberculoid leprosy, and has symptoms including skin lesions, sensory loss and motor loss. An important gene associated with Leprosy is LTA (lymphotoxin alpha (TNF superfamily, member 1)), and among its related pathways are THC Differentiation Pathway and Antigen processing and presentation. The drugs thalidomide and rifampin and the compounds glucose and sp 600125 have been mentioned in the context of this disorder. Affiliated tissues include superficial peripheral nerves, skin and mucous membranes of the upper respiratory tract, and related mouse phenotypes are renal/urinary system and liver/biliary system.

Disease Ontology: A primary bacterial infectious disease that results in infection located in superficial peripheral nerves, located in skin, located in mucous membranes of the upper respiratory tract, located in anterior chamber of the eyes, or located in testes, has material basis in mycobacterium leprae, which is transmitted by aerosol spread from infected nasal secretions to exposed nasal and oral mucosa. the infection has symptom skin lesions, has symptom sensory loss, has symptom motor loss and has symptom eye damage.⁶

Wikipedia: Leprosy, also known as Hansen\'s disease (HD), is a chronic disease caused by the bacteria Mycobacterium...⁴⁴ more...

OMIM: 607572

Aliases & Descriptions:

leprosy 6 8 33 43

Disease types for leprosy family:

leprosy 4	leprosy 5

Diseases related to leprosy by text searches and GeneDecks gene sharing:

(show top 50)    (show all 985)

id	Related Disease	Score	Top Affiliating Genes
1	lepromatous leprosy	36.9	IL10, IL2, IL4, IFNG, HSPD1, LTA
2	tuberculoid leprosy	33.5	IL10, IL2RA, IFNG
3	tuberculosis	32.4	VDR, CD209, IL10, IL12B, IL1B, IL1RN
4	malaria	30.7	CD40LG, IL10, IL4, IFNG, IFNGR2, TNF
5	pulmonary tuberculosis	29.2	VDR, CD80, CD247, IL10, IL12B, IL12RB1
6	antiphospholipid syndrome	29.0	CD79A, CD40LG, APOH, MBL2, IGHE, F3
7	mycobacterial infection	28.8	CD209, CD247, IL10, IL12B, IL12RB1, IL15
8	macroglobulinemia	26.9	ZAP70, CD79A, CD40LG, CD40, IL10, IL1B
9	parkinson's disease	26.9	SERPINA3, PACRG, PARK2, GSR, IL15, APOE
10	hypogonadism	26.5	VDR, BGLAP, PARK2, IL1B, IL6, CCL3
11	crohn's disease	25.7	CD80, IL10, IL12B, IL12RB2, IL13, IL17A
12	neuritis	25.7	BMP6, S100A8, CD40LG, CD80, MLLT1, IL10
13	atopy	25.0	VDR, CD79A, IL10, IL12B, IL12RB2, IL13
14	sepsis	24.9	S100A8, XDH, CFB, ITGB2, IL10, IL12B
15	leishmaniasis	22.1	BMP6, CD209, CD4, ITGB2, GSR, IL10
16	osteoporosis	22.1	VDR, BMP6, BGLAP, CD79A, CD40LG, CD40
17	psoriasis	19.7	KIR2DS3, KIR2DS5, KIR3DL2, KIR3DL3, KIR2DP1, KIR2DL1
18	relapsing-remitting multiple sclerosis	14.4	IL10, IL18, IL1RN, IL2RA, MBP, CCL5
19	acute disseminated encephalomyelitis	14.3	IL10, MBP, HLA-DQA1, HLA-DQB1, HLA-DRB1, TNF
20	visceral leishmaniasis	14.3	IL10, IL4, IFNG, LTA, SLC11A1
21	chronic progressive multiple sclerosis	14.3	IL2, IL2RA, IL2RB, MBP, IFNG, TNF
22	poliomyelitis	14.2	CD40LG, IL10, IL4, IGHV4-39, IFNG, ICAM1
23	plasmodium falciparum malaria	14.2	CHIT1, ITGB2, GSR, IL10, IL18, CCL4
24	autoimmune myocarditis	14.2	ITGB2, IL12RB1, IL2, CCL2, IFNG, TNF
25	pleural tuberculosis	14.2	IL18, IL4, IFNG, TNF
26	vogt-koyanagi-harada disease	14.2	KIR2DS3, KIR2DS5, KIR3DL2, KIR3DL3, KIR2DP1, KIR2DL1
27	intermediate uveitis	14.2	IL10, IL2RA, IFNG, TNF
28	multifocal motor neuropathy	14.2	CD40LG, IL10, IL2, IL4, IFNG
29	omenn syndrome	14.2	IL10, IL1RN, IL4, IL5, IGHE, IFNG
30	htlv-1 associated myelopathy/tropical spastic paraparesis	14.2	VDR, IL2, IL2RA, MBP, HLA-A
31	folliculitis	14.2	IL2RA, IL4, IL5, CCL11, CCL5, IFNG
32	calcinosis	14.1	KIR3DL2, HLA-DQA1, HLA-DQB1, HLA-DRB1, TNF, PTH
33	tropical spastic paraparesis	14.1	ITGB2, IL15, IL2, IL2RA, IL2RB, MBP
34	periapical granuloma	14.1	IL2, IL2RA, IL4, CCL4, CCL2, CCL3
35	acute graft versus host disease	14.1	KIR3DL1, IL10, IL15, IL18, IL1RN, IL2
36	alveolar echinococcosis	14.1	IL10, IFNG, HLA-A, HLA-B, HLA-C, HLA-DQB1
37	cerebral malaria	14.1	IL10, IL12B, IL1B, IL1RN, IFNG, ICAM1
38	sympathetic ophthalmia	14.1	IL10, CCL2, HLA-C, HLA-DQA1, HLA-DRB1, TNF
39	menieres disease	14.1	IL4, IFNG, HLA-DQB1, HLA-DRB1, PTPN22, CTLA4
40	achalasia	14.1	IL10, IL2, IL23R, CALR, TNF, PTPN22
41	birdshot chorioretinopathy	14.1	KIR2DS3, KIR2DL1, KIR3DS1, KIR2DS4, KIR3DL1, KIR2DS2
42	pulmonary sarcoidosis	14.1	CD80, IL12B, IL12RB1, IL18, IL2, IL2RA
43	chronic venous leg ulcers	14.1	ITGB2, F2, F13A1, HLA-B, HLA-DRB1, TNF
44	eosinophilic meningitis	14.1	IL10, IL2, IL4, IL5
45	autoimmune thyroiditis	14.1	CD80, CD40, ITGB2, IL12B, IL2RA, IL4
46	primary systemic mycosis	14.1	CD79A, IL10, IL4, IGHV4-39, TNF
47	cysticercosis	14.1	IL10, IL18, IL4, IGHE, TNF
48	sezary's disease	14.0	IL15, IL2, IL2RA, IL2RB, IL4, IL5
49	cblc	14.0	ZAP70, LCK, IL12RB1, IL12RB2, IL23R, IL2RA
50	tubulointerstitial nephritis and uveitis	14.0	HLA-DQA1, HLA-DQB1, HLA-DRB1

Clinical features from OMIM: 607572
Symptoms: skin lesions, sensory loss, motor loss, eye damage.⁶

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 rifampin, thalidomide

MalaCards organs/tissues related to leprosy:

²²

FMA organs/tissues related to leprosy:

¹¹

MGI Mouse Phenotypes related to leprosy:

²⁵ (show all 22)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	renal/urinary system phenotype	MP:0005367	10.5	HSD11B2, IFNGR1, ANXA4, APOE, MLLT1, CFB
2	liver/biliary system phenotype	MP:0005370	10.2	CTLA4, LSR, TLR2, TLR4, SOD1, EFS
3	respiratory system phenotype	MP:0005388	9.7	EFS, ELN, LRRK2, CYLD, PTPN22, F13A1
4	endocrine/exocrine gland phenotype	MP:0005379	9.4	GGT1, TLR2, LRRK2, LTA, CTLA4, CYLD
5	digestive/alimentary phenotype	MP:0005381	9.3	EFS, IL12B, CD4, VDR, IL17A, IL18
6	other phenotype	MP:0005395	8.8	CSF2, STAT3, TLR2, NOS2, PTGS2, TNFRSF1A
7	skeleton phenotype	MP:0005390	8.7	ERBB2, TNFRSF1A, PTGS2, PTH, CTLA4, NOD2
8	nervous system phenotype	MP:0003631	8.6	PKD2L1, NTRK1, TNFRSF1A, HLA-DQB1, HLA-C, NGF
9	vision/eye phenotype	MP:0005391	8.5	NGF, NOS2, NTRK1, PTGS2, TNFRSF1A, LTA
10	hematopoietic system phenotype	MP:0005397	8.1	LRRK2, IL5, IL23R, IL17A, IL12RB2, IL12RB1
11	reproductive system phenotype	MP:0005389	8.0	NOS2, PTGS2, TNP1, TNFRSF1A, TNF, NFIC
12	normal phenotype	MP:0002873	7.9	ERBB2, HSD11B2, ALB, F2, F3, IFNG
13	tumorigenesis	MP:0002006	7.9	ERBB2, TNF, TNFRSF1A, PTGS2, CYLD, NOS2
14	muscle phenotype	MP:0005369	7.8	NTRK1, PTGS2, TNFRSF1A, TNF, HLA-DQB1, NOS2
15	behavior/neurological phenotype	MP:0005386	7.5	CRBN, NTRK1, CYLD, TNFRSF1A, HLA-DQB1, HLA-C
16	integument phenotype	MP:0010771	7.5	NGF, RPS6KA4, NTRK1, CTLA4, CYLD, LSR
17	immune system phenotype	MP:0005387	7.2	GGT1, RIPK2, SLC11A1, CSF2, PRKCE, STAT3
18	cardiovascular system phenotype	MP:0005385	7.1	NOS2, CRP, CTLA4, PTH, PTGS2, TNFRSF1A
19	growth/size phenotype	MP:0005378	6.7	NTRK1, CYLD, PTPN22, PTH, ERBB2, CALR
20	mortality/aging	MP:0010768	6.1	S100A8, LAMA2, PARK2, VDR, NAGLU, S100A9
21	cellular phenotype	MP:0005384	4.7	LUM, RIPK2, CSF2, SOD1, PRKCE, STAT3
22	homeostasis/metabolism phenotype	MP:0005376	3.6	RPS6KA4, NOS2, NOD2, CRP, CTLA4, CYLD

Articles related to leprosy:

(show top 50)    (show all 212)

id	Title	Authors	Year	Affiliating Genes
1	Th3 immune responses in the progression of leprosy vi a molecular cross-talks of TGF-I^, CTLA-4 and Cbl-b. (21807564)	Kumar S.... Rao D.N.	2011	TGFB1, CBLB, CTLA4
2	The recurrence of leprosy reactional episodes could b e associated with oral chronic infections and expression of serum IL-1, TNF-alp ha, IL-6, IFN-gamma and IL-10. (20640364)	Motta A.C.... Foss N.T.	2010	TNF, IL6, IFNG
3	Evidence for an association of HLA-DRB1*15 and DRB1*0 9 with leprosy and the impact of DRB1*09 on disease onset in a Chinese Han popu lation. (20003324)	Zhang F.... Liu J.	2009	HLA-DRB1, HLA-S
4	Increased chitotriosidase activity in serum of leprosy patients: association with bacillary leprosy. (19307157)	Iyer A.... Das P.K.	2009	TNF, IL6, IFNG
5	Polymorphisms in Toll-like receptor 4 (TLR4) are associated with protection against leprosy. (19430824)	Bochud P.Y.... Kaplan G.	2009	TLR4
6	No involvement of non-synonymous TLR2 polymorphisms i n Japanese leprosy patients. (19111445)	Mikita N.... Furukawa F.	2009	TLR2
7	Polymorphism N248S in the human Toll-like receptor 1 gene is related to leprosy and leprosy reactions. (19456232)	Schuring R.P.... Oskam L.	2009	TLR1
8	The 3'UTR 1188 A/C polymorphism in the interleukin-12p40 gene (IL-12B) is associated with lepromatous leprosy in the west of Mexico. (18485489)	Alvarado-Navarro A.... Fafutis-Morris M.	2008	IL12B
9	Association of leprosy with HLA-DRB1 in an Argentinean population. (18275683)	Borras S.G.... Racca A.	2008	HLA-DRB1
10	Influence of TNF and IL10 gene polymorphisms in the immunopathogenesis of leprosy in the south of Brazil. (19058987)	Franceschi D.S.... Visentainer J.E.	2008	TGFB1, TNF, IL6
11	Analysis of the BTNL2 truncating splice site mutation in tuberculosis, leprosy and Crohn's disease. (17493147)	Johnson C.M.... Trowsdale J.	2007	BTNL2
12	HLA-DRB1*04 and DRB1*10 are associated with resistance and susceptibility, respectively, in Brazilian and Vietnamese leprosy patients. (17396103)	Vanderborght P.R.... Moraes M.O.	2007	HLA-DRB1
13	Erythrocyte superoxide dismutase, catalase activities and hydrogen peroxide induced lipid peroxidation in leprosy. (18309714)	Prasad C.V.... Kodliwadmath G.B.	2007	CAT
14	Alteration of the cortisol-cortisone shuttle in leprosy type 1 reactions in leprosy patients in Hyderabad, India. (17320974)	Andersson A.K.... Lockwood D.N.	2007	HSD11B2
15	Role of HLA-DR and HLA-DQ alleles in multibacillary leprosy and paucibacillary leprosy in the province of Chaco (Argentina) (18053473)	Motta P.M.... Habegger de Sorrentino A.	2007	HLA-DQB1, HLA-DRB1, HLA-DRB4
16	Cyclooxygenase 2 expression in vessels and nerves in reversal reaction leprosy. (16760523)	Pesce C.... Fiallo P.	2006	PTGS2
17	Variation in MICA and MICB genes and enhanced susceptibility to paucibacillary leprosy in South India. (16923796)	Tosh K.... Pitchappan R.	2006	HLA-DRB1, MICB, MICA
18	Genetics of host response in leprosy. (17171999)	Moraes M.O.... Pacheco A.G.	2006	PARK2, IL10
19	Interaction of TaqI polymorphism at exon 9 of the vitamin D receptor gene with the negative lepromin response may favor the occurrence of leprosy. (16965356)	Goulart L.R.... Goulart I.M.	2006	VDR
20	Pituitary-gonadal hormones and interleukin patterns in leprosy. (16930264)	Leal A.M.... Foss N.T.	2006	IL6
21	Circulating levels of tissue factor and proinflammatory cytokines in patients with primary antiphospholipid syndrome or leprosy related antiphospholipid antibodies. (15751817)	Forastiero R.R.... de LarraA+aga G.F.	2005	F3
22	Immune profiling of leprosy and tuberculosis patients to 15-mer peptides of Mycobacterium leprae and M. tuberculosis GroES in a BCG vaccinated area: implications for development of vaccine and diagnostic reagents. (15056384)	Hussain R.... Dockrell H.M.	2004	HSPE1
23	Chromosome 6q25 is linked to susceptibility to leprosy in a Vietnamese population. (12577057)	Mira M.T.... Schurr E.	2003	PACRG
24	Activation and regulation of Toll-like receptors 2 and 1 in human leprosy. (12692544)	Krutzik S.R.... Modlin R.L.	2003	TLR1
25	Study of HLA-DR expression on skin lesions of leprosy before and during multiple drug therapy. (12211894)	Abdel Latif A.M.... Essa E.A.	2002	IFNG
26	Association of a missense mutation of the laminin alpha2 gene with tuberculoid type of leprosy in Indonesian patients. (12100448)	Wibawa T.... Matsuo M.	2002	LAMA2
27	Expression of inducible nitric oxide synthase and nitrotyrosine in borderline leprosy lesions. (11736907)	SchAPn T.... Britton S.	2001	NOS2
28	T-cell release of granulysin contributes to host defense in leprosy. (11175847)	Ochoa M.T.... Modlin R.L.	2001	GNLY
29	A major susceptibility locus for leprosy in India maps to chromosome 10p13. (11279529)	Siddiqui M.R.... Hill A.V.	2001	LPRS1
30	Association of NRAMP1 polymorphism with leprosy type but not susceptibility to leprosy per se in west Africans. (11791966)	Meisner S.J.... Hill A.V.	2001	SLC11A1
31	The effect of antigen presenting cells on the cytokine profiles of stable and reactional lepromatous leprosy patients. (11163869)	Nath I.... Ramesh V.	2000	IL4, IFNG
32	Granulomatous reaction to intradermal injection of lepromin (Mitsuda reaction) is linked to the human NRAMP1 gene in Vietnamese leprosy sibships. (10608779)	Alcais A.... Abel L.	2000	SLC11A1
33	Role of granulysin in immunity to leprosy. (11201866)	Ochoa M.T.... Modlin R.L.	2000	GNLY
34	A role for CD40-CD40 ligand interactions in the generation of type 1 cytokine responses in human leprosy. (10903757)	Yamauchi P.S.... Modlin R.L.	2000	CD40
35	Cytokine mRNA expression in leprosy: a possible role for interferon-gamma and interleukin-12 in reactions (RR and ENL). (10564558)	Moraes M.O.... Sampaio E.P.	1999	LTA
36	Multibacillary leprosy: lesions with macrophages positive for S100 protein and dendritic cells positive for Factor 13a. (9870671)	Cuevas-Santos J.... McNutt N.S.	1998	S100B
37	Cytokines in leprosy, I. Serum cytokine profile in leprosy. (9802682)	Moubasher A.D.... Raheem D.D.	1998	IL2RA, IFNG, IL10
38	Suppression of tumour necrosis factor-alpha expression in leprosy skin lesions during treatment for leprosy. (9115924)	Sugita Y.... Nakajima H.	1997	TNF
39	Induction of Th1 cytokine responses by mycobacterial antigens in leprosy. (8926118)	Dockrell H.M.... Hussain R.	1996	IFNG
40	Mycobacterium leprae DNA content, cellular and cytokine patterns in skin lesions of leprosy patients undergoing multidrug therapy (MDT). (7713552)	Flad H.D.... Gerdes J.	1994	IFNG
41	Development of a whole blood assay to measure T cell responses to leprosy: a new tool for immuno-epidemiological field studies of leprosy immunity. (7963598)	Weir R.E.... Dockrell H.M.	1994	IFNG
42	Development of giant reaction in response to PPD skin test in lepromatous leprosy patients. (8371029)	Sampaio E.P.... Sarno E.N.	1993	IFNG
43	Anaemia, iron-related measurements and erythropoietin levels in untreated patients with active leprosy. (1402625)	Lapinsky S.E.... Bothwell T.H.	1992	TF
44	Leprosy. (1730174)	Meyers W.M.	1992	IL2, IFNG
45	The systemic influence of recombinant interleukin 2 on the manifestations of lepromatous leprosy. (2007862)	Kaplan G.... Barker J.	1991	IL2
46	T cell reactivity to the purified mycobacterial antig ens p65 and p70 in leprosy patients and their household contacts. (2192825)	Adams E.... Basten A.	1990	RPA1
47	Immunologic defects in leprosy patients. II. Interleukin 1, interleukin 2, and interferon production in leprosy patients. (1695911)	Makonkawkeyoon S.... Vithayasai V.	1990	IL2
48	Atopy and IgE in patients with leprosy. (2182698)	Smith D.L.... Clements B.H.	1990	IGHE
49	An unusual case of Hansen's disease (lepromatous leprosy) with circulating anticoagulant and macroglobulinemia. (2119410)	Desai R.G.	1990	F2
50	Widespread intradermal accumulation of mononuclear le ukocytes in lepromatous leprosy patients treated systemically with recombinant interferon gamma. (2121891)	Nathan C.... Sanchez E.	1990	IFNG

Genes related to leprosy according to GeneCards:

(show top 50)    (show all 183)

id	Symbol	Description	Score	GeneCards Section Context
1	LTA	lymphotoxin alpha (TNF superfamily, member 1)	11.1	Summaries, Publications
2	LPRS1	Leprosy, susceptibility to 1	11.1	Aliases & Descriptions, Publications
3	LPRS6	Leprosy, susceptiblity to, 6	11.0	Aliases & Descriptions
4	SLC11A1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	11.0	Summaries, Publications
5	IL12RB2	interleukin 12 receptor, beta 2	11.0	Summaries, Publications
6	PACRG	PARK2 co-regulated	11.0	Expressions, Publications, UniProt Related, Summaries
7	TLR1	toll-like receptor 1	11.0	Publications, UniProt Related
8	TLR2	toll-like receptor 2	11.0	Publications
9	IL10	interleukin 10	11.0	Publications
10	IFNG	interferon, gamma	11.0	Publications
11	IL4	interleukin 4	11.0	Publications
12	IL2RA	interleukin 2 receptor, alpha	11.0	Publications
13	IL2	interleukin 2	11.0	Publications
14	VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	11.0	Publications
15	TNF	tumor necrosis factor	11.0	Publications
16	PARK2	parkinson protein 2, E3 ubiquitin protein ligase (parkin)	11.0	Publications
17	ENSG00000183748		11.0	UniProt Related, Publications
18	MRC1	mannose receptor, C type 1	11.0	UniProt Related, Publications
19	CD2	CD2 molecule	11.0	Publications
20	DEFB1	defensin, beta 1	11.0	Publications
21	IFNGR2	interferon gamma receptor 2 (interferon gamma transducer 1)	11.0	Publications
22	IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	11.0	Publications
23	IFNGR1	interferon gamma receptor 1	11.0	Publications
24	IL12RB1	interleukin 12 receptor, beta 1	11.0	Publications
25	HSPA1A	heat shock 70kDa protein 1A	11.0	Publications
26	HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	11.0	Publications
27	HSPD1	heat shock 60kDa protein 1 (chaperonin)	11.0	Publications
28	HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	11.0	Publications
29	HLA-DRB1	major histocompatibility complex, class II, DR beta 1	11.0	Publications
30	ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	11.0	Publications
31	IL18	interleukin 18 (interferon-gamma-inducing factor)	11.0	Publications
32	ICAM1	intercellular adhesion molecule 1	11.0	Publications
33	MBP	myelin basic protein	11.0	Publications
34	IL1RN	interleukin 1 receptor antagonist	11.0	Publications
35	F2	coagulation factor II (thrombin)	11.0	Publications
36	CR1	complement component (3b/4b) receptor 1 (Knops blood group)	11.0	Publications
37	NOS2	nitric oxide synthase 2, inducible	11.0	Publications
38	TRGJ2	T cell receptor gamma joining 2	10.9	Disorders
39	MIR181A1	microRNA 181a-1	10.9	Publications
40	KIR2DP1	killer cell immunoglobulin-like receptor, two domains, pseudogene 1	10.9	Publications
41	IGHV4-39	immunoglobulin heavy variable 4-39	10.9
42	KIR3DP1	killer cell immunoglobulin-like receptor, three domains, pseudogene 1	10.9	Publications
43	CD300C	CD300c molecule	10.9	Publications
44	TNP1	transition protein 1 (during histone to protamine replacement)	10.9	Publications
45	MLEC	malectin	10.9
46	GNLY	granulysin	10.9	Publications
47	LACC1	laccase (multicopper oxidoreductase) domain containing 1	10.9	Publications
48	HLA-S	major histocompatibility complex, class I, S (pseudogene)	10.9	Publications
49	SNX20	sorting nexin 20	10.9	Publications
50	RAB32	RAB32, member RAS oncogene family	10.9	Publications

Pathways related to leprosy according to GeneDecks:

(show top 50)    (show all 154)

id	Pathway	Score	Top Affiliating Genes
1	THC Differentiation Pathway36	11.0	IL10, IL12B, IL12RB1, IL12RB2, IL18, IL18R1
2	Antigen processing and presentation20	10.9	KIR2DS3, KIR2DS5, KIR3DL2, KIR3DL3, KIR2DL1, KIR2DL3
3	Th1 Differentiation37	10.7	CD4, CD80, IL10, IL12B, IL12RB1, IL12RB2
4	Graft-versus-host disease20	10.6	KIR3DL2, KIR2DL1, KIR2DL3, KIR3DL1, KIR2DL5A, KIR2DL2
5	Jak-STAT signaling pathway20	10.5	IL10, IL12B, IL12RB1, IL12RB2, IL13, IL15
6	Intestinal immune network for IgA production20	10.4	CD40LG, CD80, CD40, IL10, IL15, IL2
7	Asthma20	10.3	CD40LG, CD40, IL10, IL13, IL4, IL5
8	Autoimmune thyroid disease20	10.2	CD40LG, CD80, CD40, IL10, IL2, IL4
9	Type I diabetes mellitus20	10.2	CD80, IL12B, IL1B, IL2, IFNG, HSPD1
10	Measles20	10.2	SH2D1A, CD209, IL12B, IL13, IL1B, IL2
11	Akt Signaling36	10.1	CD2, CD4, CD80, ITGB2, IL10, IL12B
12	RAR-Gamma-RXR-Alpha Degradation36	10.1	CD2, CD80, IL15, IL2, IL7, CCL4
13	Natural killer cell mediated cytotoxicity20	10.1	SH2D1A, KIR2DS3, KIR2DS5, KIR3DL2, KIR2DL1, KIR2DL3
14	Immune response IL-22 signaling pathway10	10.0	CD4, IL12B, IL12RB1, IL12RB2, IL2, IL2RA
15	Allograft rejection20	10.0	CD40LG, CD80, CD40, IL10, IL12B, IL2
16	Tuberculosis20	10.0	VDR, MRC1, CD209, ITGB2, IL10, IL12B
17	Regulation of eIF4 and p70S6K36	10.0	CD2, CD4, CD80, ITGB2, IL12B, IL13
18	Toxoplasmosis20	9.8	LAMA2, CD40LG, CD40, IL10, IL12B, MAPK3
19	Hematopoietic cell lineage20	9.8	CD2, CD4, CD1B, CD1A, IL1B, IL2RA
20	Leishmaniasis20	9.8	ITGB2, IL10, IL12B, IL1B, IL4, MAPK3
21	Immune System38	9.7	KIR2DS5, KIR3DL2, KIR2DL1, KIR2DL3, KIR2DL4, KIR3DS1
22	NFAT Signaling and Lymphocyte Interactions36	9.7	BMP6, CD2, CD4, CD80, IL12B, IL13
23	Cytokine Network36	9.6	IL10, IL12B, IL13, IL15, IL18, IL1B
24	Influenza A20	9.4	IL12B, IL18, IL1B, IL6, IL8, MAPK3
25	Th17 Differentiation37	9.4	CD4, CD80, IL12B, IL12RB1, IL17A, IL1B
26	Chagas disease (American trypanosomiasis)20	9.3	CD247, IL10, IL12B, IL1B, IL6, MAPK3
27	Malaria20	9.2	CD40LG, CD40, ITGB2, IL10, IL18, IL1B
28	Toll-like receptor signaling pathway20	9.1	CD80, CD40, IL12B, IL1B, IL6, IL8
29	Rheumatoid arthritis20	9.1	CD80, ITGB2, IL15, IL17A, IL18, IL1B
30	PGC1Alpha Pathway36	9.0	BMP6, CD2, CD4, CD80, IL12B, IL13
31	Molecular Mechanisms of Cancer36	8.7	BMP6, LAMA2, CD2, CD4, CD80, ITGB2
32	SOCS Pathway36	8.7	BMP6, CD2, CD4, CD80, IL10, IL12B
33	IL-6 Pathway36	8.6	BMP6, CD2, CD80, IL10, IL12B, IL18
34	PAK Pathway36	8.6	BMP6, CD2, CD80, IL10, IL12B, IL13
35	all-trans-Retinoic Acid Signaling in Brain36	8.5	BMP6, CD2, CD80, IL10, IL12B, IL13
36	Cytokine-cytokine receptor interaction20	8.4	CD40LG, CD40, IL10, IL12B, IL12RB1, IL12RB2
37	Endothelin-1 Signaling Pathway36	8.3	BMP6, CD2, CD80, IL10, IL12B, IL13
38	PEDF Induced Signaling36	8.2	BMP6, CD2, CD80, IL10, IL12B, IL13
39	Tec Kinases Signaling36	8.1	BMP6, CD2, CD4, CD80, ITGB2, IL10
40	TGF-Beta Pathway36	8.0	BMP6, CD2, CD4, CD80, IL10, IL12B
41	Glucocorticoid Receptor Signaling36	8.0	BMP6, CD2, CD4, CD80, IL10, IL12B
42	MIF Mediated Glucocorticoid Regulation36	7.7	BMP6, CD2, CD80, IL10, IL12B, IL13
43	MIF Regulation of Innate Immune Cells36	7.7	BMP6, CD2, CD80, IL10, IL12B, IL13
44	STAT3 Pathway36	7.7	BMP6, CD2, CD4, CD80, IL10, IL12B
45	Rho Family GTPases36	7.6	BMP6, LAMA2, CD2, CD80, ITGB2, IL10
46	JAK-STAT Pathway36	7.6	BMP6, CD2, CD4, CD80, IL10, IL12B
47	p38 Signaling36	7.6	BMP6, ZAP70, LCK, CD2, CD4, CD80
48	Antioxidant Action of Vitamin-C36	7.4	BMP6, CD2, CD4, CD80, IL10, IL12B
49	MAPK Family Pathway36	7.4	BMP6, CD2, CD4, CD80, IL10, IL12B
50	ERK Signaling36	7.2	BMP6, ZAP70, LAMA2, CD2, CD80, ITGB2

Compounds related to leprosy according to GeneDecks:

(show top 50)    (show all 437)

id	Compound	Score	Top Affiliating Genes
1	glucose32	10.9	LPO, PARK2, S100A12, S100B, CFB, CD2
2	sp 60012532 42	11.6	CD40, IL13, IL17A, TLR2
3	ivig32	10.3	S100A12, IL18R1, MBP, CCL4, CRP, LTA
4	ionomycin32	10.1	SERPINA3, LCK, CD2, CD40, IL12RB1, IL5
5	ascorbic acid32 18	11.1	LPO, VDR, BGLAP, S100B, CD40LG, IL2RA
6	allergens32	9.7	S100A8, CD209, CD79A, CD40LG, CD80, CD40
7	pge232	9.7	CD4, GSR, IL13, IL17A, IL1RN, IL5
8	groalpha32	9.7	IL10, IL13, IL17A, IL18, IL1B, CCL4
9	amphotericin b32	9.5	IL13, IL1RN, IL4, IL5, CCL4, CCL5
10	calcitriol32 42 9 18 9	13.5	VDR, BMP6, BGLAP, S100A8, S100A9, IL13
11	estrogen32	9.5	SERPINA3, VDR, BGLAP, PARK2, S100B, GSR
12	adenylate32	9.4	VDR, S100B, CD40LG, CD40, ITGB2, GSR
13	lipoteichoic acid32	9.3	IL10, IL12B, IL18, IL1B, IL1RN, IL6
14	aspartate32	9.3	NAGLU, VDR, BMP6, S100B, CD40LG, ITGB2
15	thalidomide32 42 9 9	12.2	CD40LG, ITGB2, IL10, IL18, IL18R1, IL1B
16	oxygen32 18	10.2	SERPINA3, NAGLU, LPO, PARK2, SDHD, ZAP70
17	infliximab32 9 9	11.1	BGLAP, IL10, IL15, IL17A, IL18, IL18R1
18	leukotriene b432 42 18	11.0	ITGB2, IL13, IL1B, IL1RN, IL2RB, IL5
19	betacarotene32	8.9	SERPINA3, VDR, CD79A, GSR, IL10, IL2RA
20	tacrolimus32 34 9 9	11.8	NAGLU, VDR, BMP6, CD79A, CD40, IL10
21	methacholine32 9 9	10.7	CD79A, IL13, IL17A, IL2RB, IL4, IL5
22	paraffin32	8.7	SERPINA3, BGLAP, S100A8, S100B, CD79A, CD40LG
23	neopterin32	8.5	NAGLU, CHIT1, CD79A, CD4, CD40LG, CD40
24	15-deoxy-delta-12,14-prostaglandin j232	8.5	BMP6, IL10, IL1B, IL4, IL6, IL8
25	thyroxine32 18	9.5	SERPINA3, LPO, VDR, BGLAP, CD79A, CD40LG
26	fibrinogen32	8.5	SERPINA3, CHIT1, S100A9, CD79A, CD40LG, CD40
27	ccl332	8.5	IL10, IL13, IL15, IL18, IL1B, IL6
28	cysteine32	8.5	KIR2DS4, SERPINA3, NAGLU, LPO, VDR, BGLAP
29	cyclosporin a32 42	9.4	NAGLU, VDR, BGLAP, S100B, CD2, CD80
30	triptolide32	8.4	CD40, IL1B, IL2, IL6, IL8, MAPK1
31	fmlp32	8.4	SERPINA3, S100A9, ITGB2, IL13, IL1B, IL1RN
32	heparin32 9 18 9	11.4	SERPINA3, BGLAP, ZAP70, LAMA2, CD79A, CD4
33	polysaccharide32	8.2	SERPINA3, BMP6, CHIT1, MRC1, CD209, CD79A
34	arginine32	8.1	KIR2DL4, SERPINA3, LPO, VDR, BGLAP, S100B
35	iron32 18	9.1	SERPINA3, NAGLU, LPO, PARK2, SDHD, CHIT1
36	calcium32 9 18 9	11.1	SH2D1A, SERPINA3, VIL1, NAGLU, LPO, BGLAP
37	hydrocortisone32 9 9	10.0	BMP6, BGLAP, CD40, IL10, IL13, IL15
38	glutamate32	8.0	VDR, BMP6, LCK, S100A8, CD79A, CD4
39	histamine32 18	9.0	BMP6, BGLAP, S100A8, CD79A, CD40LG, CD40
40	cholesterol32 9 18 9	11.0	SERPINA3, NAGLU, S100A8, S100A9, CD4, CD40
41	creatinine32	7.9	SERPINA3, NAGLU, VDR, BMP6, LAMA2, S100A8
42	curcumin32	7.7	IL15, IL17A, IL18, IL1B, IL6, IL8
43	lipid32	7.6	KIR2DL1, KIR3DL1, SERPINA3, NAGLU, LPO, PARK2
44	cisplatin32 34 9 9	10.6	NAGLU, BMP6, BGLAP, XDH, CD40LG, GSR
45	genistein32 9 18 9	10.3	VDR, ZAP70, LCK, CD4, CD40LG, CD40
46	actinomycin d32	7.1	VDR, CD40LG, CD40, IL13, IL17A, IL1B
47	nitric oxide32 9 18 9	9.9	NAGLU, LPO, BMP6, PARK2, S100A8, S100A9
48	retinoic acid32 42 18	8.7	KIR2DS4, SERPINA3, VDR, BMP6, BGLAP, S100A8
49	lactate32	6.4	NAGLU, LPO, BMP6, ZAP70, S100B, XDH
50	dexamethasone32 42 34 9 9	9.3	SERPINA3, VDR, BMP6, BGLAP, ZAP70, LCK

Cellular components related to leprosy according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	10.4	HLA-DRB4, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-C, HLA-B
2	ER to Golgi transport vesicle membrane	GO:012507	10.4	HLA-DRB4, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-C, HLA-B
3	integral to plasma membrane	GO:005887	10.4	CD40, KIR2DS5, KIR2DS3, KIR3DL2, KIR2DL1, CD1A
4	phagocytic vesicle membrane	GO:030670	10.2	SLC11A1, TLR6, TLR1, HLA-C, HLA-B, HLA-A
5	MHC class I protein complex	GO:042612	10.2	HLA-C, HLA-B, HLA-A, MICA, MICB, CD1A
6	endosome membrane	GO:010008	10.0	TLR4, SNX20, HLA-DQB1, HLA-DQA1, ERBB2, CD1A
7	external side of plasma membrane	GO:009897	9.9	TLR4, IL17A, IL13, IL12RB1, CD40, CD40LG
8	cell surface	GO:009986	9.8	TGFB1, TLR2, PKD2L1, NOD2, CR1, NTRK1
9	plasma membrane	GO:005886	8.2	HLA-C, MBP, APOE, IL2RB, IL2RA, IL1RN
10	extracellular space	GO:005615	6.4	LUM, LYZ, CSF3, CSF2, SOD1, TGFB1
11	extracellular region	GO:005576	6.4	HLA-C, F13A1, ALB, F2, HTRA4, IFNG

Biological processes related to leprosy according to GeneDecks:

(show top 50)    (show all 104)

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of growth of symbiont in host	GO:044130	11.1	TIRAP, TLR2, LTA, TNF, IFNG, IL10
2	interferon-gamma-mediated signaling pathway	GO:060333	11.0	HLA-DQB1, IFNG, IFNGR1, IFNGR2, ICAM1, HLA-A
3	defense response to bacterium	GO:042742	10.8	LYZ, IL10, MICA, S100A12, IFNG, GNLY
4	T-helper 1 type immune response	GO:042088	10.8	IL18, IL12B, TLR6, TLR4, HLA-DRB4, HLA-DRB1
5	positive regulation of tumor necrosis factor production	GO:032760	10.7	TLR4, TLR2, NOD2, NOD1, TNFRSF1A, IL18
6	cellular response to interferon-gamma	GO:071346	10.7	NOS2, CCL3, CCL2, IL18, IL12RB1, IL12B
7	defense response to Gram-positive bacterium	GO:050830	10.7	TNF, MBL2, LTA, TIRAP, RIPK2, TLR2
8	T cell receptor signaling pathway	GO:050852	10.7	PTPN22, HLA-DQA1, HLA-DRB4, CD4, RIPK2, HLA-DRB1
9	positive regulation of interferon-gamma production	GO:032729	10.6	CD40LG, IL12B, IL12RB1, IL12RB2, IL18, RIPK2
10	positive regulation of interleukin-17 production	GO:032740	10.6	IL15, IL2, IL23R, NOD2, TGFB1, IL12B
11	positive regulation of osteoclast differentiation	GO:045672	10.6	CCL5, TNF, IFNG, IL23R, IL17A, IL12B
12	positive regulation of inflammatory response	GO:050729	10.6	IL2, IL12B, IL15, IL18, CCL3, TLR2
13	positive regulation of interleukin-12 production	GO:032735	10.6	IL12B, IL23R, CCR7, IFNG, HSPD1, TLR2
14	regulation of immune response	GO:050776	10.6	ITGB2, MICB, IL4, ICAM1, HLA-A, HLA-B
15	positive regulation of chemokine production	GO:032722	10.5	IL18, IL6, TNF, TLR2, TLR4, RIPK2
16	detection of bacterium	GO:016045	10.4	HLA-B, HLA-DRB1, HLA-DRB4, NOD1, HLA-A, NOD2
17	humoral immune response	GO:006959	10.4	IFNG, TNF, LTA, IL6, CCL2, LTF
18	defense response to Gram-negative bacterium	GO:050829	10.4	NOS2, SLC11A1, TLR4, IL6, IL23R, IL12B
19	response to bacterium	GO:009617	10.4	CHIT1, NOS2, CCL2, SLC11A1, DEFB1, VIL1
20	T cell costimulation	GO:031295	10.4	HLA-DRB4, CTLA4, HLA-DRB1, CD80, HLA-DQA1, CD247
21	positive regulation of activated T cell proliferation	GO:042104	10.3	IL4, IL23R, IL2, IL12B, IL12RB1, IL18
22	positive regulation of B cell proliferation	GO:030890	10.3	IL13, TIRAP, TLR4, IL7, IL5, IL4
23	positive regulation of interleukin-6 production	GO:032755	10.3	RIPK2, TLR4, TLR2, NOD2, NOD1, TNF
24	positive regulation of interleukin-6 biosynthetic process	GO:045410	10.3	TIRAP, TLR6, IL1B, IFNG, TLR1
25	positive regulation of JNK cascade	GO:046330	10.2	TIRAP, IL1B, TNF, NOD1, NOD2, CCR7
26	positive regulation of T cell proliferation	GO:042102	10.2	IL4, IL6, IFNG, CCL5, IL15, IL23R
27	toll-like receptor signaling pathway	GO:002224	10.1	RIPK2, TIRAP, TLR6, TLR2, MAPK3, TLR4
28	MyD88-dependent toll-like receptor signaling pathway	GO:002755	10.1	TLR4, NOD1, RIPK2, HSPD1, TIRAP, TLR2
29	cell-cell signaling	GO:007267	10.1	IL10, IL13, IL15, IL17A, IL18, IL1B
30	cellular calcium ion homeostasis	GO:006874	10.1	CALR, CCL5, PTH, TGFB1, CCL3, CCL11
31	positive regulation of ERK1 and ERK2 cascade	GO:070374	10.1	TLR4, MAPK3, CCL3, CCR7, NTRK1, TNF
32	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	10.1	S100A12, TNFRSF1A, RIPK2, PARK2, TIRAP, TLR6
33	positive regulation of nitric oxide biosynthetic process	GO:045429	10.0	IL1B, TLR2, IFNG, TNF, PTGS2, TLR4
34	response to ethanol	GO:045471	9.8	IL13, SOD1, STAT3, TNFRSF1A, ICAM1, CCL2
35	toll-like receptor 1 signaling pathway	GO:034130	9.8	MAPK3, MAPK1, NOD1, RIPK2, TLR4, TIRAP
36	response to lipopolysaccharide	GO:032496	9.7	S100A8, IL13, PTGS2, IL23R, CCR7, IDO1
37	toll-like receptor 2 signaling pathway	GO:034134	9.7	RIPK2, TIRAP, TLR6, TLR2, NOD2, NOD1
38	lipopolysaccharide-mediated signaling pathway	GO:031663	9.7	TLR4, TGFB1, PRKCE, RIPK2, TLR2, IL18
39	response to glucocorticoid stimulus	GO:051384	9.6	IL1RN, CCL5, TNF, BGLAP, IL10, IL1B
40	response to drug	GO:042493	9.6	IFNG, ICAM1, HSD11B2, CALR, TNF, PTGS2
41	cytokine-mediated signaling pathway	GO:019221	9.6	IL12RB1, IL12RB2, IL1B, IL2RB, IL5, IL6
42	MAPK cascade	GO:000165	9.4	IL1B, MAPK3, TGFB1, LRRK2, TNF, CCL5
43	innate immune response	GO:045087	9.3	CFB, CD209, CD4, IL18R1, TLR4, MAPK3
44	activation of MAPK activity	GO:000187	9.3	SOD1, LRRK2, IL1B, NOD2, NOD1, TNF
45	virus-host interaction	GO:019048	9.2	STAT3, MAPK3, CD80, CD209, LCK, HLA-C
46	immune response	GO:006955	9.1	HLA-DRB4, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-C, HLA-B
47	positive regulation of NF-kappaB transcription factor activity	GO:051092	8.9	TLR4, TLR2, RPS6KA4, NOD2, NTRK1, TNF
48	signal transduction	GO:007165	8.5	KIR2DL4, MAPK1, ANXA4, IL8, IL1B, IL18R1
49	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.4	NFIC, TLR2, TLR4, TGFB1, STK16, SLC11A1
50	inflammatory response	GO:006954	6.9	SERPINA3, NOD1, RPS6KA4, CRP, PTGS2, TNFRSF1A

Molecular functions related to leprosy according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	MHC class II receptor activity	GO:032395	10.6	HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB4
2	receptor activity	GO:004872	10.5	IL18R1, ICAM1, TLR1, TLR2, TLR4, TLR6
3	CCR5 chemokine receptor binding	GO:031730	10.1	STAT3, CCL5, CCL3, CCL4
4	transmembrane signaling receptor activity	GO:004888	10.0	ERBB2, TLR1, TLR2, TLR4, TLR6, ICAM1
5	chaperone binding	GO:051087	9.8	SOD1, CALR, HSPD1, HSPE1, ALB, PARK2
6	chemokine activity	GO:008009	9.6	CCL5, CCL3, CCL11, CCL2, CCL4, IL8
7	receptor binding	GO:005102	9.6	LTA, NOS2, TNFSF15, HLA-B, HLA-A, CAT
8	cytokine activity	GO:005125	9.2	BMP6, IL6, IL7, CCL4, IFNG, TNF
9	growth factor activity	GO:008083	9.1	IL7, F2, NGF, TGFB1, CSF2, CSF3
10	protein homodimerization activity	GO:042803	8.6	NTRK1, CRP, NOD1, NOS2, LRRK2, TIRAP
11	protein binding	GO:005515	4.2	PTPN22, CYLD, CTLA4, NTRK1, SNX20, CRBN