MCID: LPR003
MIFTS: 77

Leprosy malady

Infectious diseases, Neuronal diseases, Reproductive diseases, Rare diseases, Skin diseases, Eye diseases categories

Summaries for Leprosy

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9Disease Ontology, 66Wikipedia, 48OMIM, 34MalaCards
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Disease Ontology:9 A primary bacterial infectious disease that results in infection located in superficial peripheral nerves, located in skin, located in mucous membranes of the upper respiratory tract, located in anterior chamber of the eyes, or located in testes, has material basis in mycobacterium leprae, which is transmitted by aerosol spread from infected nasal secretions to exposed nasal and oral mucosa. the infection has symptom skin lesions, has symptom sensory loss, has symptom motor loss and has symptom eye damage.

MalaCards: Leprosy, also known as leprosy, susceptibility to, is related to lepromatous leprosy and tuberculoid leprosy, and has symptoms including sensory loss, motor loss and eye damage. An important gene associated with Leprosy is TLR2 (toll-like receptor 2), and among its related pathways are IL4-mediated signaling events and Defensins. The drug thalidomide and the compounds alpha-galactosylceramide and toxin-1 have been mentioned in the context of this disorder. Affiliated tissues include superficial peripheral nerves, skin and mucous membranes of the upper respiratory tract, and related mouse phenotypes are no phenotypic analysis and renal/urinary system.

Wikipedia:66 Leprosy, also known as Hansen\'s disease (HD), is a chronic infection caused by the bacteria... more...

Description from OMIM:48 246300, 607572, 609888, 610988, 613223 613407 more

Aliases & Classifications for Leprosy

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Sources:
9Disease Ontology, 48OMIM, 11DISEASES, 50Orphanet, 63UMLS, 10diseasecard, 36MeSH, 41NCIt, 59SNOMED-CT, 28ICD9CM, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 26ICD10
See all sources

Classifications:



Aliases & Descriptions:

leprosy 9 48 11 50 63
leprosy, susceptibility to 10


External Ids:

Disease Ontology9 DOID:1024
MeSH36 D007918
NCIt41 C84824
ICD9CM28 030, 030.9
MESH via Orphanet37 D007918
ICD10 via Orphanet27 A30.0, A30.1, A30.2 A30.3, A30.4, A30.5, A30.8, A30.9, more
SNOMED-CT via Orphanet60 81004002
UMLS via Orphanet64 C0023343
ICD1026 A30, A30.9

Related Diseases for Leprosy

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Leprosy family:

Leprosy 5 Leprosy 4

Diseases related to Leprosy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 290)
idRelated DiseaseScoreTop Affiliating Genes
1lepromatous leprosy31.8TLR2, IFNG, IL4, IL2, IL10, LTA
2tuberculoid leprosy31.6IL10, IL2RA, IFNG
3tuberculosis30.4TLR2, TLR1, TNF, IFNGR1, IFNG, IL4
4leishmaniasis30.4IFNGR1, IFNG, IL4, IL10, SLC11A1
5filariasis30.3TLR2
6cutaneous leishmaniasis30.2IFNG, IL10
7arthritis30.2TLR2, TNF, IFNG, IL4, IL10, SLC11A1
8tetanus30.1TLR2, IFNG, IL4, IL2, IL2RA, IL10
9sarcoidosis30.1DEFB1, TNF, IFNGR1, IFNG, IL12RB2, IL2
10hepatitis c30.1TLR2, IFNG, IL10, IL12B
11pulmonary tuberculosis30.1IL2RA, IL10, IL12B, SLC11A1, IL2, IL4
12hepatitis b30.1TLR2, IFNG, IL2RA, IL10, IL12B
13malaria30.0CD2, IL12B, IL10, IFNG, IFNGR1, TNF
14uveitis29.9TNF, IFNG, IL4, IL2RA, IL10, LTA
15psoriasis29.9TLR2, TNF, IFNG, IL4, IL2, IL2RA
16periapical granuloma29.9IL4, IL2RA
17atopy29.9TLR2, IFNG, IL12RB2, IL4, IL10, IL12B
18myasthenia gravis29.8IFNG, IL4, IL2, IL10, LTA
19connective tissue disease29.7TNF, IL4, IL2, IL2RA, IL10
20systemic lupus erythematosus29.7IL4, IL2, IL2RA, IL10, IL12B, CD2
21melanoma29.6TNF, IFNG, IL4, IL2, IL10, CD2
22rheumatoid arthritis29.6TLR2, TNF, PARK2, IFNG, IL4, IL2
23sepsis29.6DEFB1, TLR2, TLR1, TNF, IL10, IL12B
24leukemia29.3TLR2, TNF, PARK2, IFNG, IL4, IL2
25borderline leprosy10.8
26indeterminate leprosy10.7
27hansen's disease10.6
28lagophthalmos10.5
29foot drop10.4
30neuropathy10.4
31hepatitis10.3
32neuritis10.3
33syphilis10.3
34molluscum contagiosum10.2
35amyloidosis10.2
36glomerulonephritis10.2
37leprosy 510.2
38chromoblastomycosis10.2
39periodontitis10.1TLR2
40mononeuritis multiplex10.1
41iridocyclitis10.1
42lupus erythematosus10.1
43mononeuritis10.1
44dysautonomia10.1
45tularemia10.1TLR2
46farmer's lung10.1IL2RA
47intraocular lymphoma10.1IL10
48tonsillitis10.1LTA
49aspergillosis10.1TLR2, IFNG
50blau syndrome10.1TNF

Graphical network of the top 20 diseases related to Leprosy:



Diseases related to leprosy

Symptoms for Leprosy

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Sources:
48OMIM, 9Disease Ontology
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Symptoms by clinical synopsis from OMIM:

246300

Clinical features from OMIM:

246300,607572,609888,610988,613223,613407

Symptoms:

9
  • sensory loss
  • motor loss
  • eye damage
  • skin lesions

Drugs & Therapeutics for Leprosy

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Leprosy

Drug clinical trials:

Search ClinicalTrials for Leprosy

Search NIH Clinical Center for Leprosy

Search CenterWatch for Leprosy

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Leprosy

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Anatomical Context for Leprosy

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34MalaCards, 15FMA
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MalaCards organs/tissues related to Leprosy:

34
Skin, Eye, T cells, Testes, Monocytes, Bone, Bone marrow, Lymph node, Whole blood, Liver, Myeloid, Endothelial, Nk cells, Olfactory bulb, Tongue, Appendix, Breast, Pituitary, Kidney, Colon, Heart, Retina, Spleen

FMA organs/tissues related to Leprosy:

15
Superficial peripheral nerves, Skin, Mucous membranes of the upper respiratory tract, Anterior chamber of the eyes, Testes

Animal Models for Leprosy or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Leprosy:

38 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.7TNF, PARK2, IFNG, IL4, IL2, IL10
2MP:00053678.3DEFB1, TLR2, IFNGR1, IFNG, IL12RB2, IL4
3MP:00053828.2TNF, IFNG, IL4, IL10, IL12B, KRT10
4MP:00053888.1TLR2, TNF, PARK2, IFNG, IL4, IL2
5MP:00036317.8TNF, PARK2, IFNGR1, IFNG, IL4, IL10
6MP:00053857.8TLR2, TNF, PARK2, IFNGR1, IFNG, IL12RB2
7MP:00053707.8TLR2, TNF, IFNGR1, IFNG, IL12RB2, IL4
8MP:00053797.8TLR2, TNF, IFNGR1, IFNG, IL12RB2, IL4
9MP:00053867.7TLR2, TNF, PARK2, IFNGR1, IFNG, IL2
10MP:00107717.6TLR2, TNF, PARK2, IFNGR1, IFNG, IL4
11MP:00053907.6TLR2, TNF, PARK2, IFNGR1, IFNG, IL4
12MP:00053787.5TLR2, TNF, PARK2, IFNG, IL4, IL2
13MP:00053847.4TLR2, TNF, PARK2, IFNGR1, IFNG, IL4
14MP:00053767.0TLR2, TNF, PARK2, IFNGR1, IFNG, IL12RB2
15MP:00020066.9IFNG, IFNGR1, TNF, TLR2, IL12RB2, IL2
16MP:00053816.9TLR2, TNF, IFNGR1, IFNG, IL12RB2, IL4
17MP:00053976.2IL12RB2, IFNG, IFNGR1, TNF, TLR1, TLR2
18MP:00107685.6IFNG, IFNGR1, PARK2, TNF, TLR2, DEFB1
19MP:00053875.2LTA, DEFB1, TLR2, TLR1, TNF, IFNGR1

Publications for Leprosy

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Sources:
53PubMed
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Articles related to Leprosy:

(show top 50)    (show all 1627)
idTitleAuthorsYear
1
Borderline lepromatous leprosy with type 1 (downgrading) reaction. (24252148)
2013
2
Interleukin-17F single-nucleotide polymorphism (7488T>C) and its association with susceptibility to leprosy. (24164796)
2013
3
Role of HLA, KIR, MICA, and cytokines genes in leprosy. (23936864)
2013
4
History of infectious diseases development in the Old and the Middle Ages with the emphasis on the plague and leprosy. (23984623)
2013
5
Intolerance to leprosy multi-drug therapy: more common in women? (24428115)
2013
6
Genetic evidence of TAP1 gene variant as a susceptibility factor in Indian leprosy patients. (23395648)
2013
7
Bacterial load in the nose and its correlation to the immune response in leprosy patients. (23741885)
2013
8
The effect of systemic corticosteroid therapy on the expression of toll-like receptor 2 and toll-like receptor 4 in the cutaneous lesions of leprosy Type 1 reactions. (22348338)
2012
9
Identification of serological biomarkers of infection, disease progression and treatment efficacy for leprosy. (23283458)
2012
10
Comparing the clinical and histological diagnosis of leprosy and leprosy reactions in the INFIR cohort of Indian patients with multibacillary leprosy. (22745841)
2012
11
Leprosy among migrant workers: ensuring proper treatment. (23614250)
2012
12
Histopathological examination of nerve samples from pure neural leprosy patients: obtaining maximum information to improve diagnostic efficiency. (22415265)
2012
13
Hansen's disease (Leprosy): current and future pharmacotherapy and treatment of disease-related immunologic reactions. (22392826)
2012
14
Characterization of the profession/occupation of individuals affected by leprosy and the relationship with limitations in professional activities. (23077777)
2012
15
Is there a relation between hemicrania continua and leprosy? (23720896)
2012
16
Chronic rhinitis: a manifestation of leprosy. (21938685)
2011
17
Cytokine and protein markers of leprosy reactions in skin and nerves: baseline results for the North Indian INFIR cohort. (22180790)
2011
18
Leprosy elimination campaign in Qazvin province, Islamic Republic of Iran (2006-07). (22355944)
2011
19
Study of cytokine response against panel of purified Mycobacterium leprae antigens by using whole blood assay in subjects residing in a resettlement village of cured leprosy patients. (21229844)
2010
20
SNP 668C (-44) alters a NF-kappaB1 putative binding site in non-coding strand of human beta-defensin 1 (DEFB1) and is associated with lepromatous leprosy. (19460328)
2009
21
Functional haplotypes that produce normal ficolin-2 levels protect against clinical leprosy. (19434912)
2009
22
A case of recurrent rash and leg numbness mimicking systemic rheumatic disease: the occurrence of leprosy in a nonendemic area. (17551381)
2007
23
Leprosy masquerading as Melkersson-Rosenthal syndrome. (16353526)
2005
24
Tuberculoid leprosy confined to glans penis in two cases. (15282972)
2004
25
Linkage of leprosy susceptibility to Parkinson's disease genes. (15301585)
2004
26
Lepromatous leprosy with extensive unusual ulcerations and cachexia. Is it the first case of Lucio's phenomenon from Iran? (15217312)
2004
27
Molluscum contagiosum-like lesions in lepromatous leprosy. (15267197)
2003
28
Localized linear lesions in lepromatous leprosy. (11898466)
2001
29
Association and linkage of leprosy phenotypes with HLA class II and tumour necrosis factor genes. (11477474)
2001
30
Cutaneous cryptococcosis associated with lepromatous leprosy. (11589749)
2001
31
Sequential erythema nodosum leprosum and reversal reaction with similar lesional cytokine mRNA patterns in a borderline leprosy patient. (11167702)
2001
32
Lagophthalmos in leprosy. (9598404)
1998
33
The current situation of lagophthalmos and keratopathy of leprosy in PR China. (9598407)
1998
34
Charles Bonnet syndrome in leprosy; prevalence and clinical characteristics. (8712028)
1996
35
Host parasite response in nerve in leprosy. (8727123)
1996
36
Localized borderline lepromatous leprosy. (8537706)
1995
37
Reply: 'Results of surgical procedures for the correction of foot-drop and lagophthalmus due to leprosy'. (7861931)
1994
38
Comment: 'Results of surgical procedures for the correction of foot-drop and of lagophthalmus due to leprosy'. (8231612)
1993
39
Tongue involvement in lepromatous leprosy. (8425797)
1993
40
Electrocardiographic alterations in lepromatous leprosy patients with concomitant Trypanosoma cruzi infection. (8228450)
1993
41
Lepromatous leprosy: nasal manifestations and treatment with minocycline. (1543336)
1992
42
Camptodactyly simulating claw hand in a patient with indeterminate leprosy. (1783793)
1991
43
In vitro effect of interleukin-2 on proliferative responses of peripheral blood T cells from leprosy patients. (1781183)
1991
44
Single lesion subpolar lepromatous leprosy and its possible mode of origin. (2659697)
1989
45
Evaluation of anti-cardiolipin antibody and its cross-reactivity in sera of patients with lepromatous leprosy. (3740940)
1986
46
Should indeterminate leprosy ever be diagnosed? (7195888)
1981
47
Mechanism of nerve destruction in tuberculoid-borderline leprosy. An electron-microscopic study. (4582968)
1973
48
The Kveim test in lepromatous and tuberculoid leprosy. (5394258)
1969
49
Pure neural tuberculoid leprosy. (4283894)
1965
50
ELECTRON MICROSCOPIC STUDY OF BORDERLINE LEPROSY. (14166266)
1963

Variations for Leprosy

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Expression for genes affiliated with Leprosy

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Leprosy

Search GEO for disease gene expression data for Leprosy.

Pathways for genes affiliated with Leprosy

About this section
Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 61Thomson Reuters, 58SinoBiological, 55R&D Systems, 31KEGG, 62Tocris Bioscience, 5Cell Signaling Technology, 54QIAGEN
See all sources

Pathways related to Leprosy according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7LTA, IL10, IL4
2
Show member pathways
9.6TLR1, TLR2, DEFB1
39.5IL2, IFNG, TNF
4
Show member pathways
9.5LTA, TNF, TLR1, TLR2
5
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways61
Immune response IL 1 signaling pathway61
9.4TLR2, TLR1, TNF, IL18RAP
69.4IL12B, TNF, TLR2
7
Show member pathways
9.4TLR2, TLR1, IL2, IL2RA
89.4IL10, IFNG, TNF, TLR2
9
Show member pathways
IL2 signaling events mediated by STAT539
9.3IL4, IL2, IL2RA, LTA
109.3IL18RAP, IL2RA, IL2, IFNG
119.2IFNG, IL4, IL2, IL2RA
129.2IL4, IL2, IL2RA, IL10
139.2TNF, IFNG, IL4, IL2
14
Show member pathways
Ras signaling in the CD4+ TCR pathway39
9.2IL2RA, IL2, IFNG, TNF
15
Show member pathways
9.2TLR2, TLR1, TNF, IL2, LTA
169.1IFNG, IL12RB2, IL2RA, IL12B
179.1IL12B, IFNG, TNF, TLR2
189.1IFNG, IL4, IL2, IL10, LTA
19
Show member pathways
Immune response IL 22 signaling pathway61
G protein signaling N RAS regulation pathway61
9.1IL12RB2, IL2, IL2RA, IL12B
209.0TNF, IL4, IL2RA, CD2
219.0TNF, IFNG, IL10, IL12B
22
Show member pathways
9.0TLR2, TLR1, IFNG, IL4, IL12B
23
Show member pathways
9.0TLR2, TLR1, TNF, IL12B, LTA
24
Show member pathways
IL-9 Signaling Pathway39
Development Thrombopoietin regulated cell processes61
IL-7 Signaling Pathway39
Immune response IL 9 signaling pathway61
8.9TNF, IL4, IL2, IL2RA, LTA
25
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
8.9IL10, IL2, IL4, IFNG, TNF
26
Show member pathways
8.9TNF, IFNG, IL2, IL2RA, IL10
27
Show member pathways
Calcium signaling in the CD4+ TCR pathway39
8.9TNF, IFNG, IL4, IL2, IL2RA
288.8IL12B, IL10, IFNG, TNF, TLR2
29
Show member pathways
8.8LTA, IFNG, IFNGR1, TNF
30
Show member pathways
8.8TNF, IFNGR1, IFNG, LTA
318.6TLR2, TLR1, TNF, IFNGR1, IFNG
32
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
8.5TNF, IFNG, IL2, IL10, IL12B, IL18RAP
338.4TNF, IFNG, IL4, IL2, IL10, IL12B
34
Show member pathways
Immune response CD16 signaling in NK cells61
8.4TNF, IFNGR1, IFNG, IL4, IL2
35
Show member pathways
Immune response IL 12 induced IFN gamma production61
8.3IFNG, IL12RB2, IL4, IL2, IL2RA, IL12B
368.2TNF, IFNG, IL4, IL2, IL10, IL12B
37
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
8.1TLR2, TLR1, TNF, IFNGR1, IFNG, IL4
387.8TLR2, TLR1, TNF, IFNGR1, IFNG, IL10
39
Show member pathways
7.6TLR2, TLR1, TNF, IFNGR1, IFNG, IL4
40
Show member pathways
7.5TNF, IL12RB2, IL4, IL2, IL2RA, IL10
41
Show member pathways
7.5TNF, IL12RB2, IL4, IL2, IL2RA, IL10
42
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
7.5TLR2, TLR1, TNF, IFNGR1, IFNG, IL2
43
Show member pathways
Type III interferon signaling39
7.4IFNGR1, IFNG, IL12RB2, IL4, IL2, IL2RA
44
Show member pathways
7.1TLR2, TNF, IFNGR1, IFNG, IL4, IL2
45
Show member pathways
7.1IL12RB2, TNF, TLR1, TLR2, IL4, IL2
46
Show member pathways
6.9IL10, IL12B, IL18RAP, IL2, IL4, IL12RB2
47
Show member pathways
6.8TNF, IFNGR1, IFNG, IL12RB2, IL4, IL2
48
Show member pathways
IL27-mediated signaling events39
6.8LTA, TLR2, TLR1, TNF, IFNGR1, IFNG
49
Show member pathways
6.4IL12RB2, IFNG, IFNGR1, TNF, IL4, IL2
50
Show member pathways
6.2IFNGR1, IFNG, IL12RB2, IL4, IL2, IL2RA

Compounds for genes affiliated with Leprosy

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 30IUPHAR, 62Tocris Bioscience, 3BitterDB, 25HMDB
See all sources

Compounds related to Leprosy according to GeneCards/GeneDecks:

(show top 50)    (show all 135)
idCompoundScoreTop Affiliating Genes
1alpha-galactosylceramide469.7IL10, IFNG, IL4, IL2
2toxin-1469.6LTA, IL10, IL2, TNF
3glatiramer acetate46 1210.6IL10, IFNG, IL2, IL4
4betaseron469.5IFNG, IL10, IL4
5natalizumab46 1210.5IL2RA, IFNG, IL10, TNF
6gold sodium thiomalate469.5IFNG, IL2RA, IL2, TNF
7ifn-alpha469.4PARK2, IL2, IL10, IL2RA, IFNG
8interferon gamma469.4TNF, IL2, IL4, IFNG, IL10
9etanercept46 52 1211.3TNF, IFNG, LTA, IL10
10gm-csf46 3010.3IL10, IL2, IL4, IFNG, TNF
112,5-oligoadenylate469.3TNF, IL2, IL2RA, IL10, IFNG
125 aminosalicylic acid469.2IL10, TNF, IL2RA, IL12B
13peptidoglycan46 3010.2IL10, TLR1, TNF, TLR2, IL12B
14poly(i-c)469.2TLR2, IL4, IFNG, IL12B, TNF
15thalidomide46 52 62 1212.1IL10, IL2RA, IL2, IFNG, TNF
16infliximab46 52 1211.1IFNG, LTA, TNF, IL4, IL2RA, IL10
17ivig469.1IFNG, TNF, IL4, IL2RA, IL10, LTA
18chloroquine46 3 52 30 1213.1TNF, IL10, IL2RA, IL2, IL4
19mycophenolate mofetil46 52 1211.1LTA, TNF, IL2RA, IFNG, IL10, IL2
20lipoteichoic acid469.1TNF, IL10, IL12B, TLR1, TLR2, LTA
21prednisolone46 30 1211.1TNF, IFNG, IL2, IL2RA, IL10, LTA
22imiquimod46 62 30 1212.0IL10, IFNG, TNF, TLR1, TLR2, IL12B
23polymyxin b469.0IL10, IL4, IFNG, TNF, TLR2, DEFB1
24herbimycin a46 6210.0LTA, IL2RA, TNF, IL4, IFNG, IL2
25con a469.0IFNG, IL4, CD2, IL10, IL2RA, IL2
26endotoxin469.0LTA, TNF, IFNG, TLR2, IL12B, IL10
27rolipram46 62 3011.0IL4, IL10, TNF, IFNG
28hydrocortisone46 3 62 1211.9IL4, IL10, IFNG, TNF, IL2
29il-12468.8IL2, IL4, IL10, IFNG, IL12B, TNF
30okt3468.8IL10, IL2RA, LTA, TNF, IFNG, IL4
31neopterin468.8TNF, IL4, IL2, IL2RA, IL10, IFNG
32tacrolimus46 52 1210.8IFNG, IL10, IL2RA, IL2, IL4, TLR2
33indomethacin46 30 62 1211.8IL4, TNF, IL2, LTA, IL2RA, IFNG
34histamine46 30 2510.7IL2, IL4, IL2RA, IL10, IFNG, TNF
35polyinosinic-polycytidylic acid468.7IL12B, IL10, IL4, IFNG, TNF, TLR2
36sb 20358046 629.6TNF, IFNG, IL4, IL10, IL12B, TLR2
37vitamin d468.5LTA, IL12B, SLC11A1, KRT10, TLR2, IL2RA
38nitric oxide46 25 1210.4TLR2, TNF, LTA, IL10, SLC11A1, PARK2
39thymidine46 259.4CD2, IL10, IL2RA, IL4, IFNG, IL2
40vegf468.4LTA, IFNG, PARK2, TNF, TLR2, IL2RA
41cycloheximide468.4IL10, TLR2, IL2, TNF, IL4, IL12B
42pentoxifylline46 129.3IL2RA, IL10, IL2, IL12B, IL4, IFNG
43ionomycin468.2LTA, IL10, IL2RA, IL4, IFNG, CD2
44rantes468.2DEFB1, IL4, IL2, IL2RA, IL10, IL12B
45cyclosporin a46 30 6210.2LTA, TLR2, TNF, IFNG, IL4, IL2
46il 10468.1TLR2, TNF, IFNG, IL4, IL2, IL2RA
47pge2468.1TNF, IFNG, IL4, IL2, IL2RA, IL10
48calcitriol46 62 25 1211.0IL2RA, TLR2, KRT10, LTA, IL10, IL2
49dexamethasone46 52 30 1210.5IL2RA, DEFB1, TLR2, TNF, IFNG, IL4
50tyrosine467.0IL4, IFNGR1, TLR2, LTA, CD2, IL12RB2

GO Terms for genes affiliated with Leprosy

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Sources:
17Gene Ontology
See all sources

Cellular components related to Leprosy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Toll-like receptor 1-Toll-like receptor 2 protein complexGO:03535410.0TLR1, TLR2
2external side of plasma membraneGO:0098978.4CD2, TLR2, TNF, IFNG, IL12RB2, IL4
3integral component of plasma membraneGO:0058877.7TLR2, TLR1, TNF, IFNGR1, IL12RB2, CD2
4extracellular spaceGO:0056157.5TNF, IFNG, IL4, IL2, IL10, IL12B

Biological processes related to Leprosy according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idNameGO IDScoreTop Affiliating Genes
1cellular response to triacyl bacterial lipopeptideGO:07172710.4TLR2, TLR1
2detection of triacyl bacterial lipopeptideGO:04249510.4TLR2, TLR1
3positive regulation of chronic inflammatory response to antigenic stimulusGO:00287610.3TNF, LTA
4regulation of isotype switchingGO:04519110.2IL4, IL10
5positive regulation of interleukin-18 productionGO:03274110.2TLR2, TNF
6positive regulation of vitamin D biosynthetic processGO:06055710.2TNF, IFNG
7positive regulation of calcidiol 1-monooxygenase activityGO:06055910.2TNF, IFNG
8regulation of T cell homeostatic proliferationGO:04601310.2IL2, IL2RA
9type 2 immune responseGO:04209210.2IL10, IL4
10positive regulation of interleukin-6 biosynthetic processGO:04541010.1TLR1, IFNG
11receptor biosynthetic processGO:03280010.1TNF, IL10
12positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.1TNF, LTA
13macrophage activationGO:04211610.1TLR1, SLC11A1
14negative regulation of cytokine secretion involved in immune responseGO:00274010.1IL10, TNF
15defense response to Gram-positive bacteriumGO:05083010.1TLR2, TNF, LTA
16positive regulation of MHC class II biosynthetic processGO:04534810.1IL10, IL4, IFNG
17positive regulation of isotype switching to IgG isotypesGO:04830410.0IL2, IL4, IFNG
18positive regulation of nitric oxide biosynthetic processGO:04542910.0IFNG, TNF, TLR2
19positive regulation of cytokine secretionGO:05071510.0TLR2, TNF, IL10
20protein import into nucleus, translocationGO:00006010.0SLC11A1, IFNG, TNF
21positive regulation of chemokine biosynthetic processGO:04508010.0TNF, IFNG, IL4
22positive regulation of tumor necrosis factor biosynthetic processGO:0425359.9TLR1, TLR2
23negative regulation of interleukin-17 productionGO:0327009.9TLR2, IFNG, IL12B
24humoral immune responseGO:0069599.9TNF, IFNG, LTA
25positive regulation of interleukin-12 productionGO:0327359.9IL12B, IFNG, TLR2
26positive regulation of interleukin-10 productionGO:0327339.9TLR2, IL4, IL12B
27positive regulation of tissue remodelingGO:0341059.9IL2, IL12B
28positive regulation of smooth muscle cell apoptotic processGO:0343939.8IFNG, IL12B
29positive regulation of NF-kappaB import into nucleusGO:0423469.8IL12B, TNF, TLR2
30positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.8IL4, IL2, IL12B
31positive regulation of T-helper 1 type immune responseGO:0028279.7SLC11A1, IL12B
32positive regulation of inflammatory responseGO:0507299.7TLR2, IL2, IL12B
33positive regulation of osteoclast differentiationGO:0456729.7IL12B, IFNG, TNF
34positive regulation of T cell proliferationGO:0421029.7IL12B, IL4, IFNG
35defense response to bacteriumGO:0427429.6DEFB1, IFNG, IL10, SLC11A1
36natural killer cell activationGO:0301019.6CD2, IL12B, IL2
37positive regulation of interleukin-17 productionGO:0327409.6IL12B, IL2
38defense response to protozoanGO:0428329.6IFNG, IL4, IL12B, SLC11A1
39positive regulation of tumor necrosis factor productionGO:0327609.5TLR2, IFNG, IL12B, CD2
40cellular response to lipopolysaccharideGO:0712229.5IL12B, IL10, IFNG
41response to drugGO:0424939.4TNF, IFNG, IL4, IL10, LTA
42positive regulation of activated T cell proliferationGO:0421049.4IL12B, IL2RA, IL2, IL4
43cell surface receptor signaling pathwayGO:0071669.4IFNG, IL12RB2, IL2RA, IL18RAP, CD2
44inflammatory responseGO:0069549.4TLR2, TLR1, TNF, IL10, IL18RAP, SLC11A1
45positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.2TNF, IL4, IL10
46negative regulation of growth of symbiont in hostGO:0441309.1LTA, IL12B, IL10, IFNG, TNF, TLR2
47apoptotic processGO:0069159.1TLR2, TNF, IFNG, IL2RA, CD2, LTA
48positive regulation of interferon-gamma productionGO:0327299.1TNF, IL12RB2, IL2, IL12B, SLC11A1, LTA
49positive regulation of transcription from RNA polymerase II promoterGO:0459448.9TLR2, TNF, IFNG, IL4, IL2, IL10
50immune responseGO:0069558.8DEFB1, TLR2, TLR1, IL4, IL2, IL2RA

Molecular functions related to Leprosy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine receptor activityGO:0048969.7IL12B, IL12RB2
2receptor activityGO:0048729.1CD2, IL18RAP, TLR1, TLR2
3growth factor activityGO:0080839.0IL4, IL2, IL10, IL12B
4cytokine activityGO:0051258.2LTA, IL12B, IL10, IL2, IL4, IFNG

Products for genes affiliated with Leprosy

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Leprosy

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet