MCID: LPR003
MIFTS: 78

Leprosy malady

Infectious diseases, Neuronal diseases categories

Summaries for Leprosy

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Sources:
8Disease Ontology, 3CDC, 63Wikipedia, 46OMIM, 32MalaCards
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Disease Ontology:8 A primary bacterial infectious disease that results in infection located in superficial peripheral nerves, located in skin, located in mucous membranes of the upper respiratory tract, located in anterior chamber of the eyes, or located in testes, has material basis in mycobacterium leprae, which is transmitted by aerosol spread from infected nasal secretions to exposed nasal and oral mucosa. the infection has symptom skin lesions, has symptom sensory loss, has symptom motor loss and has symptom eye damage.

MalaCards: Leprosy, also known as leprosy, susceptibility to, is related to lepromatous leprosy and tuberculoid leprosy, and has symptoms including sensory loss, motor loss and eye damage. An important gene associated with Leprosy is TLR2 (toll-like receptor 2), and among its related pathways are Akt Signaling and IL27-mediated signaling events. The drug thalidomide and the compounds ionomycin and il 10 have been mentioned in the context of this disorder. Affiliated tissues include superficial peripheral nerves, skin and mucous membranes of the upper respiratory tract, and related mouse phenotypes are immune system and hematopoietic system.

CDC:3 Hansen's disease (also known as leprosy) is a long-lasting infection caused by bacteria.

Wikipedia:63 Leprosy, also known as Hansen\'s disease (HD), is a chronic infection caused by the bacteria... more...

Description from OMIM:46 246300, 607572, 609888, 610988, 613223 613407 more

Aliases & Classifications for Leprosy

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Sources:
8Disease Ontology, 46OMIM, 10DISEASES, 48Orphanet, 60UMLS, 9diseasecard, 27ICD9CM, 39NCIt, 56SNOMED-CT, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

leprosy 8 46 10 48 60
leprosy, susceptibility to 9


External Ids:

Disease Ontology8 DOID:1024
ICD9CM27 030.9, 030
NCIt39 C84824
MeSH34 D007918
MESH via Orphanet35 D007918
ICD10 via Orphanet26 A30.0, A30.1, A30.2 A30.3, A30.4, A30.5, A30.8, A30.9, more
SNOMED-CT via Orphanet57 81004002
UMLS via Orphanet61 C0023343
ICD1025 A30, A30.9

Related Diseases for Leprosy

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Leprosy family:

Leprosy 5 Leprosy 4

Diseases related to Leprosy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 322)
idRelated DiseaseScoreTop Affiliating Genes
1lepromatous leprosy31.7TLR2, IFNG, LTA, IL10, IL4, IL2
2tuberculoid leprosy31.5IL10, IL2RA, IFNG
3tuberculosis30.7SLC11A1, IL2, IL4, TLR2, TLR1, IFNGR2
4leishmaniasis30.4IFNG, IFNGR1, IL10, IL4, SLC11A1
5hepatitis30.4LTA, TLR2
6sarcoidosis30.4IL12RB1, IL2, SLC11A1, IL12B, IL12RB2, IFNGR2
7pulmonary tuberculosis30.3IL10, IL12B, IL12RB1, IL4, IL2, SLC11A1
8malaria30.2TLR2, IFNG, IFNGR1, TNF, CD2, IL10
9arthritis30.2TLR2, IFNG, TNF, LTA, IL10, IL4
10tetanus30.2TLR2, IFNG, LTA, IL2RA, IL10, IL4
11psoriasis30.1TLR2, IFNG, TNF, LTA, IL2RA, IL10
12cutaneous leishmaniasis30.1IFNG, IL10
13systemic lupus erythematosus30.0TLR2, IFNG, IFNGR1, TNF, LTA, CD2
14hepatitis c30.0TLR2, IFNG, TNF, IL10, IL12B, IL4
15hepatitis b30.0TLR2, IFNG, IL2RA, IL10, IL12B
16filariasis30.0TLR2
17rheumatoid arthritis29.9TLR2, PARK2, SLC11A1, IL2, IL4, IL12RB1
18uveitis29.9IL4, IL10, IL2RA, LTA, TNF, IFNG
19dermatitis29.9IFNG, IL4
20mycosis fungoides29.9IL2, IL2RA
21crohn's disease29.9TNF
22rhinitis29.9IL4
23vasculitis29.9TNF
24leukemia29.7TLR2, IFNG, TNF, LTA, CD2, IL2RA
25myasthenia gravis29.7IFNG, LTA, IL10, IL4, IL2
26connective tissue disease29.7TNF, IL2RA, IL10, IL4, IL2
27melanoma29.7IFNG, TNF, CD2, IL10, IL4, IL2
28skin disease29.7TLR2, IFNG, TNF, IL10, IL4
29breast cancer29.7IFNGR2, IFNGR1, IL2, PARK2
30periapical granuloma29.7IL4, IL2RA
31myeloid leukemia29.7LTA
32peritonitis29.7TLR2, TNF
33osteomyelitis29.7IFNGR1
34paracoccidioidomycosis29.7IL10
35alopecia areata29.7IFNG
36myocarditis29.7IL12RB1
37parkinson's disease29.7PACRG, PARK2
38optic neuritis29.7LTA
39acquired immunodeficiency syndrome29.7IL2
40anaplastic large cell lymphoma29.7IL2RA
41sarcoma29.7IL2
42thymoma29.7IL2, CD2
43dementia29.7PARK2
44borderline leprosy10.9
45indeterminate leprosy10.6
46lagophthalmos10.4
47neuropathy10.4
48neuritis10.3
49syphilis10.2
50molluscum contagiosum10.2

Graphical network of the top 20 diseases related to Leprosy:



Diseases related to leprosy

Clinical Features for Leprosy

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Sources:
46OMIM, 8Disease Ontology
See all sources

Clinical features from OMIM:

246300,607572,609888,610988,613223,613407

Clinical synopsis from OMIM:

246300

Symptoms:

8
  • sensory loss
  • motor loss
  • eye damage
  • skin lesions

Drugs & Therapeutics for Leprosy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Leprosy

Drug clinical trials:

Search ClinicalTrials for Leprosy

Search NIH Clinical Center for Leprosy

Search CenterWatch for Leprosy

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Leprosy

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Anatomical Context for Leprosy

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Leprosy:

32
Skin, Eye, T cells, Testes, Bone, Monocytes, Bone marrow, Lymph node, Whole blood, Liver, Myeloid, Endothelial, Nk cells, Olfactory bulb, Tongue, Appendix, Breast, Pituitary, Kidney, Colon, Heart, Retina, Spleen

FMA organs/tissues related to Leprosy:

14
Superficial peripheral nerves, Skin, Mucous membranes of the upper respiratory tract, Anterior chamber of the eyes, Testes

Animal Models for Leprosy or affiliated genes

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36MGI
See all sources

Publications for Leprosy

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Sources:
50PubMed
See all sources

Articles related to Leprosy:

(show top 50)    (show all 1642)
idTitleAuthorsYear
1
Leprosy: making good progress but hidden challenges remain. (23481044)
2013
2
Degree of skin denervation and its correlation to objective thermal sensory test in leprosy patients. (23272267)
2012
3
Psychosocial aspects of Hansen's disease (leprosy). (23189247)
2012
4
Molecular mimicry between HSP 65 of Mycobacterium leprae and cytokeratin 10 of the host keratin; role in pathogenesis of leprosy. (23121977)
2012
5
The potential for vaccination in leprosy elimination: new tools for targeted interventions. (23283471)
2012
6
Oral lesions in leprosy revisited: a case report. (22456516)
2012
7
Human beta-defensin 3 is up-regulated in cutaneous leprosy type 1 reactions. (23133681)
2012
8
Increased hepcidin expression in multibacillary leprosy. (23283470)
2012
9
TNF -308G>A single nucleotide polymorphism is associated with leprosy among Brazilians: a genetic epidemiology assessment, meta-analysis, and functional study. (21917899)
2011
10
Anti-PGL-I seroepidemiology in leprosy cases: household contacts and school children from a hyperendemic municipality of the Brazilian Amazon. (22439276)
2011
11
Ulnar neuropathy as a first sign of HIV infection: a diagnostic challenge for leprosy endemic countries. (19722064)
2009
12
Inhibition of apoptosis, activation of NKT cell and upregulation of CD40 and CD40L mediated by M. leprae antigen(s) combined with Murabutide and Trat peptide in leprosy patients. (18008143)
2008
13
Tropical Diseases Targeted for Elimination: Chagas Disease, Lymphatic Filariasis, Onchocerciasis, and Leprosy (21250324)
2006
14
Mycobacterium leprae in untreated lepromatous leprosy: more than skin deep. (16681612)
2006
15
Infection by Mycobacterium leprae of household contacts of lepromatous leprosy patients from a post-elimination leprosy region of Colombia. (16410954)
2005
16
Comparative evaluation of immunotherapeutic efficacy of BCG and mw vaccines in patients of borderline lepromatous and lepromatous leprosy. (16830653)
2005
17
Reversal reaction and Mitsuda conversion in polar lepromatous leprosy: a case report. (16248213)
2005
18
Dapsone hypersensitivity syndrome in an adolescent during treatment during of leprosy. (15654479)
2004
19
Elevated free tear lactoferrin levels in leprosy are associated with Type 2 reactions. (15132380)
2004
20
Detection of IL-13, IL-10, and IL-6 in the leprosy skin lesions of patients during prednisolone treatment for type 1 (T1R) reactions. (15217318)
2004
21
Molluscum contagiosum-like lesions in lepromatous leprosy. (15267197)
2003
22
Chromosome 6q25 is linked to susceptibility to leprosy in a Vietnamese population. (12577057)
2003
23
A second case of multidrug-resistant Mycobacterium leprae isolated from a Japanese patient with relapsed lepromatous leprosy. (14608820)
2003
24
Nodular leprosy of childhood and tuberculoid leprosy: a comparative, morphologic, immunopathologic and quantitative study of skin tissue reaction. (14608817)
2003
25
A major susceptibility locus for leprosy in India maps to chromosome 10p13. (11279529)
2001
26
Some useful clinical clues and techniques in the diagnosis of tuberculoid leprosy. (11454096)
2001
27
Role of granulysin in immunity to leprosy. (11201866)
2000
28
Pentoxifylline decreases in vivo and in vitro tumour necrosis factor-alpha (TNF-alpha) production in lepromatous leprosy patients with erythema nodosum leprosum (ENL). (9486396)
1998
29
Hypogonadal osteoporosis in elderly male patients with lepromatous leprosy. (9513350)
1997
30
Host parasite response in nerve in leprosy. (8727123)
1996
31
Paralysis of facial muscles in leprosy patients with lagophthalmos. (8046261)
1994
32
Modulation of peripheral blood derived monocytes/macrophages from leprosy patients using 'tuftsin' for production of reactive oxygen intermediates. (8231600)
1993
33
Immunosuppressive roles for IL-10 and IL-4 in human infection. In vitro modulation of T cell responses in leprosy. (8515073)
1993
34
Anaemia, iron-related measurements and erythropoietin levels in untreated patients with active leprosy. (1402625)
1992
35
Mycobacterium leprae-specific T cells from a tuberculoid leprosy patient suppress HLA-DR3-restricted T cell responses to an immunodominant epitope on 65-kDa hsp of mycobacteria. (1701000)
1990
36
T cell reactivity to the purified mycobacterial antigens p65 and p70 in leprosy patients and their household contacts. (2192825)
1990
37
Estimation of high density lipoprotein cholesterol in the diagnosis of lepromatous leprosy. (3253340)
1988
38
Evidence of cell-mediated immune contrasuppression in lepromatous leprosy: modulation of a putative T contrasuppressor cell-subset. (3133142)
1988
39
The HLA association of lepromatous leprosy and borderline lepromatous leprosy in Turkey. A preliminary study. (3391713)
1988
40
Ultrastructural studies of peripheral nerves in lepromatous leprosy patients. (2848907)
1988
41
Lepromin-induced suppressor cells in lepromatous leprosy. (2948676)
1987
42
Borderline leprosy in a three year old child. (3831104)
1985
43
A single skin lesion--an unusual presentation of lepromatous leprosy. (4086919)
1985
44
Preliminary evidence of natural resistance to Mycobacterium bovis (BCG) in lepromatous leprosy. (6373625)
1984
45
Free subepidermal grenz zone (band of Unna) in lepromatous leprosy. Histological and ultrastructural findings. (6538558)
1984
46
Nerve damage in tuberculoid leprosy. (7132297)
1982
47
Mechanism of nerve destruction in tuberculoid-borderline leprosy. An electron-microscopic study. (4582968)
1973
48
Clinical observations on 'reaction' in tuberculoid leprosy: preliminary report. (5890063)
1965
49
What is leprosy? Leprosy, zara'eth, ngerengere, Hansen's disease. (13932050)
1963
50
Demonstration of South African Tuberculoid Leprosy. (19988735)
1932

Genetic Variations for Leprosy

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Expression for genes affiliated with Leprosy

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Leprosy

Search GEO for disease gene expression data for Leprosy.

Pathways for genes affiliated with Leprosy

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Sources:
51QIAGEN, 37NCBI BioSystems Database, 52R&D Systems, 29KEGG, 53Reactome, 12EMD Millipore, 55SinoBiological, 59Tocris Bioscience
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Pathways related to Leprosy according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.1IL12B, IL2, IL4, IL12RB1, IL10, IL12RB2
2
Hide members
11.1TLR2, IL12RB1, TLR1, IFNGR2, IFNG, IL2
3
Hide members
11.1IL4, IL12RB1, IL12B, IL10, LTA, TNF
4
Hide members
11.0IFNGR2, TLR2, IL2, IL12B, TNF, IFNG
511.0IFNGR2, IL12RB1, IL4, IL2, IFNG, IFNGR1
6
Hide members
11.0IL2RA, TLR1, IL2, TNF, IFNG, IFNGR1
7
Hide members
11.0IFNGR1, TLR2, IL2, IL10, TNF, IFNG
810.9IL12B, IFNGR1, TLR2, TLR1, IL10, TNF
9
Hide members
10.9DEFB1, IFNGR2, TLR1, IL2RA, IFNG, TLR2
1010.9IFNG, TNF, LTA, IL10, IL12B, IL4
11
Hide members
10.9IL12RB2, IL2RA, IL2, IL4, IL12RB1, IL12B
12
Hide members
10.9IL12B, IL2, IL12RB1, IL12RB2, IL2RA, CD2
13
Immune response Bacterial infections in normal airways
10.8IFNGR2, IFNG, IFNGR1, TLR2, TNF, TLR1
1410.8TLR2, TLR1, IFNGR2, IFNG, TNF, IFNGR1
15
Hide members
10.8IL12RB2, IL2RA, CD2, LTA, IL12B, IL12RB1
16
Development PDGF signaling via STATs and NF-kB
Hide members
10.8TNF, IL12RB1, IL2, IFNG, IL10, IL12B
17
Hide members
10.8TLR2, IFNGR2, IFNGR1, IL12RB2, IL12B, IL12RB1
18
Hide members
10.8TNF, IL4, IFNGR1, IFNG, IFNGR2, IL2
19
Hide members
10.8IL12RB1, IL12RB2, IL2RA, CD2, IFNGR1, IFNGR2
20
Hide members
10.8TLR2, TLR1, TNF, LTA, IL12B
2110.8LTA, IL10, IL2, IFNG, IL4
2210.8IL12B, TLR2, IFNG, IL10, TNF
23
Hide members
10.8IL4, LTA, TNF, IL2, IL2RA
24
Hide members
10.8IL2, IL10, IL2RA, TNF, IFNG
25
Hide members
10.7IL2, IL4, IL2RA, TNF, IFNG
26
Hide members
10.7IL12RB1, IL12B, IL12RB2, CD2, LTA
2710.7IL12RB2, IL12RB1, IL2RA, IFNG, IL12B
2810.7IL2, IL12RB1, IL12B, IL2RA, IL12RB2
29
Hide members
10.7IFNGR2, IFNG, IFNGR1, TNF, LTA
30
Hide members
10.7IL2, IFNGR2, IFNG, IFNGR1, IL2RA
31
Hide members
10.7TLR2, TLR1, TNF, LTA
32
Hide members
10.7TLR2, TLR1, TNF, LTA
33
Hide members
10.7TLR2, TLR1, IL2RA, IL2
34
Hide members
10.7IL2RA, IL4, IL2, LTA
3510.7TLR2, TNF, IL12B, IFNG
3610.7IFNG, IL2RA, IL4, IL2
37
Hide members
10.7TNF, IFNG, IFNGR1, LTA
3810.7IL2, IL2RA, TNF, IFNG
3910.7IL10, IL12B, TNF, IFNG
4010.7CD2, TNF, IL2RA, IL4
41
Hide members
10.7IFNGR2, IFNG, IFNGR1, TNF
4210.7TNF, IFNGR2, IFNG, IFNGR1
43
Hide members
10.6IFNG, IL2, IL4
4410.6IFNG, IL2, IL2RA
4510.6IL2, TNF, IFNG
4610.6TNF, IL4, IL2
4710.6IFNGR1, IFNG, IFNGR2
48
Hide members
10.6TLR1, IL12RB1
4910.5TLR2
5010.5IL12B

Compounds for genes affiliated with Leprosy

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Sources:
44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB
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Compounds related to Leprosy according to GeneCards/GeneDecks:

(show top 50)    (show all 96)
idCompoundScoreTop Affiliating Genes
1ionomycin4411.5LTA, CD2, IL2RA, IL10, IL12RB1, IL4
2il 104411.4LTA, TNF, IFNG, IL2, IL4, IL12B
3rantes4411.4TNF, TLR2, IFNG, LTA, IL12B, IL4
4calcitriol44 59 11 2414.3LTA, TLR2, IL2, IFNG, IL4, IL10
5okt34411.3IL2, IL4, IL10, IFNG, IL2RA, LTA
6il-124411.3IL10, IL4, IL2, IL12RB1, IL12B, TNF
7polyinosinic-polycytidylic acid4411.3IL12B, IFNG, TLR2, IL4, IL2, TNF
8neopterin4411.3LTA, IFNG, IL2, IL4, TNF, IL2RA
9tacrolimus44 49 1113.3IL2RA, IL2, IL4, IL10, TNF, IFNG
10imiquimod44 28 59 1114.2TLR2, TLR1, TNF, IL12B, IL10, IFNG
11polymyxin b4411.2IL10, DEFB1, TNF, IFNG, IL4, TLR2
12lipoteichoic acid4411.2TLR2, TNF, LTA, IL10, IL12B, TLR1
13con a4411.2IL4, IL2, IL10, IFNG, CD2, IL2RA
14infliximab44 49 1113.2LTA, IL2RA, IL10, IFNG, IL4, TNF
15interferon gamma4411.2TNF, IFNG, IL10, IL4, IL2
16histamine44 28 2413.2IL10, IL2, IL2RA, TNF, IFNG, TLR2
17vegf4411.2IL10, TLR2, TNF, PARK2, IL2RA, LTA
18herbimycin a44 5912.1TNF, IL2, IL4, IL2RA, LTA, IFNG
192,5-oligoadenylate4411.1TNF, IL2, IL2RA, IFNG, IL10
20nitric oxide44 11 2413.1PARK2, IFNG, LTA, IL10, IL12B, SLC11A1
21poly(i-c)4411.1IFNG, TLR2, TNF, IL12B, IL4
22peptidoglycan44 2812.1TLR2, TLR1, TNF, IL10, IL12B
23cyclosporin a44 28 5913.1IL2RA, IFNG, LTA, CD2
24thymidine44 2412.1IL2, IL4, IL10, TNF, IFNG, IL2RA
25pentoxifylline44 1112.1IL4, LTA, IL12B
26alpha-galactosylceramide4411.1IFNG, IL10, IL2, IL4
27ifn-alpha4411.1IFNG, PARK2, IL2RA, IL10, IL2
28toxin-14411.1TNF, IL2, LTA, IL10
29dexamethasone44 49 28 1114.0TLR2, LTA, DEFB1
30gold sodium thiomalate4411.0IFNG, TNF, IL2RA, IL2
31glatiramer acetate44 1112.0IL2, IL10, IFNG, IL4
32gm-csf44 2812.0IL10, TNF, IFNG
33thalidomide44 49 59 1114.0IL2, IFNG, IL2RA, IL10, TNF
34sb 20358044 5912.0IL4, IL12B, TNF, IFNG, TLR2, IL10
35tyrosine4411.0IL4, IL2, LTA, PARK2, IL12RB1, IL2RA
36chloroquine44 2 49 28 1115.0TNF, IL2RA, IL10, IL4, IL2
37natalizumab44 1112.0IL10, IL2RA, TNF, IFNG
38vitamin d4411.0LTA, IL10, SLC11A1, IL2RA, TLR2, IL12B
395 aminosalicylic acid4411.0IL10, IL2RA, TNF, IL12B
40prednisolone44 28 1113.0LTA, IL2RA
41ivig4410.9IFNG
42pge24410.9IL2
43betaseron4410.9IL10, IFNG, IL4
44cycloheximide4410.9TLR2, LTA
45etanercept44 49 1112.8TNF, LTA, IL10, IFNG
46simvastatin44 49 59 28 11 2415.8TLR2, IFNG, TNF, IL10, IL4
47mycophenolate mofetil44 49 1112.8IL2, IL10, IL2RA, IFNG
48ribavirin44 49 1112.7IL2, IL4, IFNG, IL10
49c-d4t4410.5IL2, IL2RA, IL4
50tarc4410.4IL4, IFNG, TNF, IL10

GO Terms for genes affiliated with Leprosy

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Sources:
16Gene Ontology
See all sources

Cellular components related to Leprosy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.9IL4, TLR2, IFNG, TNF, CD2, IL2RA
2integral to plasma membraneGO:00588710.8TLR2, TLR1, IFNGR2, IFNGR1, TNF, CD2
3Toll-like receptor 1-Toll-like receptor 2 protein complexGO:03535410.6TLR1, TLR2
4extracellular spaceGO:00561510.6IFNG, TNF, LTA, IL10, IL12B, IL4

Biological processes related to Leprosy according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interferon-gamma productionGO:03272911.3IL12B, LTA, IL12RB2, IL2, IL12RB1, SLC11A1
2positive regulation of transcription from RNA polymerase II promoterGO:04594411.3IL4, IL10, TNF, IFNG, TLR2, SLC11A1
3negative regulation of growth of symbiont in hostGO:04413011.3IFNG, TNF, IL10, LTA, IL12B, TLR2
4immune responseGO:00695511.2IL4, IL2, IL2RA, DEFB1, TLR2, TLR1
5positive regulation of activated T cell proliferationGO:04210411.2IL2, IL4, IL12RB1, IL12B, IL2RA
6cell surface receptor signaling pathwayGO:00716611.2IL2RA, CD2, IL12RB2, IFNGR2, IFNG
7cytokine-mediated signaling pathwayGO:01922111.2IFNGR2, IL12RB1, IFNG, IFNGR1, IL12RB2
8defense response to protozoanGO:04283211.1IL4, SLC11A1, IFNG, IL12B
9response to drugGO:04249311.1IL10, IL4, IFNG, TNF, LTA
10inflammatory responseGO:00695411.1TLR2, IL10, TNF, TLR1, SLC11A1
11defense response to bacteriumGO:04274211.1IL10, DEFB1, IFNG, SLC11A1
12positive regulation of isotype switching to IgG isotypesGO:04830411.1IL2, IL4, IFNG
13positive regulation of MHC class II biosynthetic processGO:04534811.1IL4, IL10, IFNG
14negative regulation of interleukin-17 productionGO:03270011.1TLR2, IFNG, IL12B
15positive regulation of chemokine biosynthetic processGO:04508011.1TNF, IL4, IFNG
16apoptotic processGO:00691511.1TNF, CD2, IFNG, IL2RA, LTA, TLR2
17positive regulation of T-helper 1 type immune responseGO:00282711.1IL12B, IL12RB1, SLC11A1
18positive regulation of osteoclast differentiationGO:04567211.1IFNG, IL12B, TNF
19positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252311.1IL2, IL4, IL12B
20regulation of interferon-gamma-mediated signaling pathwayGO:06033411.1IFNGR2, IFNG, IFNGR1
21natural killer cell activationGO:03010111.1CD2, IL12B, IL2
22positive regulation of NF-kappaB import into nucleusGO:04234611.0TNF, IL12B, TLR2
23protein import into nucleus, translocationGO:00006011.0IFNG, TNF, SLC11A1
24positive regulation of interleukin-12 productionGO:03273511.0TLR2, IL12B, IFNG
25response to virusGO:00961511.0TNF, IFNGR1, IFNGR2, IFNG
26positive regulation of cytokine secretionGO:05071511.0TLR2, IL10, TNF
27positive regulation of nitric oxide biosynthetic processGO:04542911.0TNF, TLR2, IFNG
28positive regulation of tumor necrosis factor productionGO:03276011.0IL12B, IFNG, TLR2
29regulation of T cell homeostatic proliferationGO:04601311.0IL2, IL2RA
30cellular response to triacyl bacterial lipopeptideGO:07172711.0TLR2, TLR1
31positive regulation of vitamin D biosynthetic processGO:06055711.0IFNG, TNF
32positive regulation of chronic inflammatory response to antigenic stimulusGO:00287611.0LTA, TNF
33detection of triacyl bacterial lipopeptideGO:04249510.9TLR1, TLR2
34defense response to Gram-positive bacteriumGO:05083010.9TLR2, TNF, LTA
35regulation of isotype switchingGO:04519110.9IL4, IL10
36humoral immune responseGO:00695910.9LTA, TNF, IFNG
37positive regulation of calcidiol 1-monooxygenase activityGO:06055910.9IFNG, TNF
38detection of diacyl bacterial lipopeptideGO:04249610.9TLR1, TLR2
39receptor biosynthetic processGO:03280010.9TNF, IL10
40positive regulation of T cell proliferationGO:04210210.8IFNG, IL4, IL12B
41positive regulation of inflammatory responseGO:05072910.8IL2, IL12B, TLR2
42positive regulation of T-helper 17 cell lineage commitmentGO:200033010.8IL12RB1, IL12B
43type 2 immune responseGO:04209210.8IL10, IL4
44positive regulation of memory T cell differentiationGO:04338210.7IL12B, IL12RB1
45negative regulation of cytokine secretion involved in immune responseGO:00274010.7TNF, IL10
46positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.7LTA, TNF
47positive regulation of smooth muscle cell apoptotic processGO:03439310.6IL12B, IFNG
48positive regulation of T-helper 17 type immune responseGO:200031810.6IL12B, IL12RB1
49positive regulation of tissue remodelingGO:03410510.5IL2, IL12B
50positive regulation of interleukin-6 biosynthetic processGO:04541010.3IFNG, TLR1

Molecular functions related to Leprosy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.9IL2, IL4, IL12B, IL10, LTA, TNF
2cytokine receptor activityGO:00489610.6IL12RB2, IL12B, IL12RB1
3interleukin-12 receptor bindingGO:00514310.6IL12RB1, IL12B
4interferon-gamma receptor activityGO:00490610.5IFNGR1, IFNGR2
5growth factor activityGO:00808310.4IL2, IL4, IL12B, IL10

Products for genes affiliated with Leprosy

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Leprosy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet