MCID: LPR003
MIFTS: 69

Leprosy malady

Categories: Genetic diseases, Infectious diseases, Neuronal diseases, Reproductive diseases, Rare diseases

Aliases & Classifications for Leprosy

Aliases & Descriptions for Leprosy:

Name: Leprosy 54 54 12 56 3 42 14 69
Leprosy, Susceptibility to 13
Leprosy 2 29
Leprosy 3 29

Characteristics:

Orphanet epidemiological data:

56
leprosy
Inheritance: Multigenic/multifactorial; Prevalence: 1-9/100000 (Worldwide); Age of onset: All ages; Age of death: any age;


Classifications:



External Ids:

Disease Ontology 12 DOID:1024
ICD10 33 A30 A30.9
ICD9CM 35 030 030.9
MeSH 42 D007918
NCIt 47 C84824
Orphanet 56 ORPHA548
UMLS via Orphanet 70 C0023343
MESH via Orphanet 43 D007918
UMLS 69 C0023343

Summaries for Leprosy

Disease Ontology : 12 A primary bacterial infectious disease that results_in infection located in superficial peripheral nerves, located in skin, located in mucous membranes of the upper respiratory tract, located in anterior chamber of the eyes, or located in testes, has material basis in Mycobacterium leprae, which is transmitted_by aerosol spread from infected nasal secretions to exposed nasal and oral mucosa. The infection has symptom skin lesions, has symptom sensory loss, has symptom motor loss and has symptom eye damage.

MalaCards based summary : Leprosy, also known as leprosy, susceptibility to, is related to lagophthalmos and tuberculosis, and has symptoms including skin lesions, sensory loss and motor loss. An important gene associated with Leprosy is TLR2 (Toll Like Receptor 2), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Rifampin and Isoniazid have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and eye, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and hematopoietic system

Wikipedia : 71 Leprosy, also known as Hansen\'s disease (HD), is a long-term infection by the bacteria Mycobacterium... more...

Description from OMIM: 246300 607572

Related Diseases for Leprosy

Diseases in the Leprosy family:

Leprosy 5 Leprosy 4

Diseases related to Leprosy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 428)
id Related Disease Score Top Affiliating Genes
1 lagophthalmos 30.5 IL10 IL4 TNF
2 tuberculosis 30.4 CD40LG IL10 IL2 IL4 TNF
3 hepatitis 30.2 HLA-DRB1 IFNG IL10 IL2 TNF
4 pulmonary tuberculosis 30.0 CD40LG IFNG IL10 IL4 TNF
5 complex regional pain syndrome 29.7 CD40LG IFNG IL10 TNF
6 cryptococcosis 29.4 CD40LG HLA-DRB1 IL10 TNF
7 myiasis 29.1 CD40LG IFNG IL10 IL2 IL4 SLC11A1
8 rheumatoid arthritis 29.0 CD40LG HLA-DRB1 IFNG IL10 IL2 IL4
9 lepromatous leprosy 12.4
10 tuberculoid leprosy 12.4
11 borderline leprosy 12.4
12 indeterminate leprosy 12.3
13 leprosy 5 12.0
14 leprosy 4 11.8
15 hansen's disease 11.7
16 chronic rhinitis 11.1
17 trigeminal trophic syndrome 11.1
18 buruli ulcer 10.7
19 colobomatous microphthalmia 10.7
20 mycobacterium kansasii 10.7
21 pyridoxal 5'-phosphate-dependent epilepsy 10.4 IL10 TNF
22 nguyen syndrome 10.4 IL10 TLR1 TLR2
23 idiopathic hypertrophic pachymeningitis 10.4 IL10 LTA TNF
24 kaposiform hemangioendothelioma 10.4 IL2 LTA
25 mycoplasmal pneumonia 10.4 TLR1 TLR2 TNF
26 parasitic ichthyosporea infectious disease 10.4 TLR1 TLR2 TNF
27 transient tic disorder 10.4 IL10 SLC11A1 TNF
28 senile reticular retinal degeneration 10.4 IFNG IL10 TNF
29 sarcomatoid transitional cell carcinoma 10.4 IL10 SLC11A1 TNF
30 pulpitis 10.4 IFNG IL10 TNF
31 steatitis 10.4 IL2 TNF
32 erb-duchenne and dejerine-klumpke palsies 10.4 IFNG IL10 TNF
33 ectothrix infectious disease 10.4 IFNG TLR1 TLR2
34 anal atresia, hypospadias, and penoscrotal inversion 10.4 IFNG SLC11A1 TLR2
35 inappropriate adh syndrome 10.4 IL10 TLR2 TNF
36 thymic neuroendocrine carcinoma 10.4 IL2 LTA TNF
37 distal trisomy 14q 10.4 HLA-DRB1 IFNG TNF
38 kernicterus due to isoimmunization 10.4 HLA-DRB1 LTA TNF
39 aseptic meningitis 10.3 HLA-DRB1 TLR2 TNF
40 myoglobinuria recurrent 10.3 IFNG IL4
41 spotted fever 10.3 CD40LG TLR2 TNF
42 follicular adenoma 10.3 IFNG IL10 TNF
43 parametritis 10.3 IFNG IL2 TNF
44 myofibroma 10.3 HLA-DRB1 IFNG IL10
45 primary ciliary dyskinesia 10.3 IL10 LTA SLC11A1 TNF
46 rift valley fever 10.3 IFNG LTA SLC11A1 TNF
47 venezuelan hemorrhagic fever 10.3 IFNG IL2 TNF
48 maturity-onset diabetes of the young 10.3 CD40LG IL10
49 childhood pleomorphic rhabdomyosarcoma 10.3 CD40LG LTA TNF
50 usher syndrome, type 2a 10.3 IFNG IL10 TLR1 TLR2

Comorbidity relations with Leprosy via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Leprosy:



Diseases related to Leprosy

Symptoms & Phenotypes for Leprosy

Symptoms by clinical synopsis from OMIM:

246300

Clinical features from OMIM:

246300 607572

Symptoms:

12
  • skin lesions
  • sensory loss
  • motor loss
  • eye damage

Human phenotypes related to Leprosy:

32
id Description HPO Frequency HPO Source Accession
1 abnormality of the immune system 32 HP:0002715

GenomeRNAi Phenotypes related to Leprosy according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.77 CD40LG IL10 IL2 LTA NOD2 PRKN
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.77 CD40LG IL10 IL2 LTA NOD2 PRKN

MGI Mouse Phenotypes related to Leprosy:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.28 CD40LG IFNG IL10 IL12RB2 IL18RAP IL2
2 homeostasis/metabolism MP:0005376 10.25 IL18RAP IL2 IL4 LTA MRC1 NOD2
3 immune system MP:0005387 10.21 CD40LG IFNG IL10 IL12RB2 IL18RAP IL2
4 digestive/alimentary MP:0005381 10.13 IFNG IL10 IL12RB2 IL2 IL4 NOD2
5 endocrine/exocrine gland MP:0005379 10.11 IL10 IL12RB2 IL2 IL4 LTA TLR2
6 mortality/aging MP:0010768 10.07 CD40LG IFNG IL10 IL2 IL4 LTA
7 liver/biliary system MP:0005370 9.92 IFNG IL10 IL12RB2 IL2 IL4 LTA
8 neoplasm MP:0002006 9.7 IFNG IL10 IL12RB2 IL2 SLC11A1 TLR2
9 respiratory system MP:0005388 9.56 IL10 IL2 IL4 LTA PRKN TLR2
10 skeleton MP:0005390 9.32 CCDC122 CD40LG IFNG IL10 IL4 LTA

Drugs & Therapeutics for Leprosy

Drugs for Leprosy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 117)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rifampin Approved Phase 4,Phase 2,Phase 3,Phase 1 13292-46-1 5458213 5381226
2
Isoniazid Approved Phase 4,Phase 1 54-85-3 3767
3
Dapsone Approved, Investigational Phase 4,Phase 1,Phase 2 80-08-0 2955
4
Clofazimine Approved, Investigational Phase 4,Phase 1,Phase 2 2030-63-9 2794
5
leucovorin Approved, Nutraceutical Phase 4,Phase 1,Phase 2 58-05-9 54575, 6560146 143
6
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 1,Phase 2 59-30-3 6037
7 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
8 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
9 Folic Acid Antagonists Phase 4,Phase 1,Phase 2
10 Cytochrome P-450 CYP3A Inducers Phase 4,Phase 2,Phase 3,Phase 1
11 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 2,Phase 3,Phase 1
12 Vitamin B Complex Phase 4,Phase 1,Phase 2
13 Vitamins Phase 4
14 Hypolipidemic Agents Phase 4,Phase 1
15 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1
16 Antimalarials Phase 4,Phase 1,Phase 2
17 Lipid Regulating Agents Phase 4,Phase 1
18 Antimetabolites Phase 4,Phase 1
19 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3,Phase 1
20 Antitubercular Agents Phase 4,Phase 2,Phase 3,Phase 1
21 Antiparasitic Agents Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
22 Antiprotozoal Agents Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
23 Folate Nutraceutical Phase 4,Phase 1,Phase 2
24 Vitamin B9 Nutraceutical Phase 4,Phase 1,Phase 2
25
Minocycline Approved, Investigational Phase 3 10118-90-8 5281021
26
Cyclosporine Approved, Investigational, Vet_approved Phase 2, Phase 3 79217-60-0, 59865-13-3 5284373 6435893
27
Goserelin Approved Phase 3 65807-02-5 47725 5311128
28
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
29
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3 22916-47-8 4189
30
Leuprolide Approved, Investigational Phase 3 53714-56-0 3911 657181
31
Miltefosine Approved Phase 3 58066-85-6 3600
32
Streptomycin Approved, Vet_approved Phase 2, Phase 3,Phase 1 57-92-1 19649
33
Clindamycin Approved, Vet_approved Phase 3 18323-44-9 29029
34
Benzoyl peroxide Approved Phase 3 94-36-0 7187
35
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
36
Clarithromycin Approved Phase 2, Phase 3 81103-11-9 84029
37 Hormone Antagonists Phase 2, Phase 3
38 Hormones Phase 2, Phase 3
39 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
40 meglumine antimoniate Phase 3,Early Phase 1
41 Prednisolone acetate Phase 2, Phase 3
42 glucocorticoids Phase 2, Phase 3
43 Adjuvants, Immunologic Phase 2, Phase 3
44 Clindamycin palmitate Phase 3
45 Clindamycin phosphate Phase 3
46 Gastrointestinal Agents Phase 2, Phase 3,Phase 1
47 Neuroprotective Agents Phase 2, Phase 3
48 Aluminum sulfate Phase 2, Phase 3
49 Cytochrome P-450 Enzyme Inhibitors Phase 2, Phase 3
50 Dermatologic Agents Phase 2, Phase 3

Interventional clinical trials:

(show all 46)
id Name Status NCT ID Phase
1 Uniform Multidrug Therapy Regimen for Leprosy Patients Completed NCT00669643 Phase 4
2 Effect of Additional Clofazimine on Erythema Nodosum Leprosum (ENL) Reactions in Leprosy Completed NCT01290744 Phase 4
3 Effect of Weight and/or Obesity on Dapsone Drug Concentrations Completed NCT01165840 Phase 4
4 Feasibility and Effectiveness of Community Based Isoniazid Preventive Therapy in Kenya Completed NCT00850915 Phase 4
5 Clinical Utility Of Genetic Screening For HLA-B*1301, On Susceptibility To Dapsone Hypersensitivity Syndrome Recruiting NCT02550080 Phase 4
6 Minocycline Therapy for Lung Scarring in Patients With Idiopathic Pulmonary Fibrosis - a Pilot Study Unknown status NCT00203697 Phase 3
7 Ciclosporin in the Management of New Type 1 Reactions in Leprosy Completed NCT00919815 Phase 2, Phase 3
8 Safety/Efficacy Trial of Killed Leishmania Vaccine in Volunteers With Positive Response to Leishmanin (LST>0) Completed NCT00429780 Phase 2, Phase 3
9 Safety/Efficacy Trial of Killed Leishmania Vaccine in Volunteers With no Response to Leishmanin Completed NCT00429715 Phase 2, Phase 3
10 Efficacy and Safety of Immunomodulator as an Adjunct Therapy in New Pulmonary Tuberculosis(Category I) Patients. Completed NCT00341328 Phase 3
11 Efficacy and Safety Study of Immunomodulator as an Adjunct Therapy in Pulmonary Tuberculosis (TB) Retreatment Patients Completed NCT00265226 Phase 3
12 Thalidomide for the Treatment of Hormone-Dependent Prostate Cancer Completed NCT00004635 Phase 3
13 Efficacy Trial on Oral Miltefosine in Comparison With Glucantime in the Treatment of ACL Caused by L. Tropica Completed NCT00351520 Phase 3
14 To Compare the Efficacy and Safety of Clindamycin Phosphate 1.2% / Benzoyl Peroxide 5% Gel of CHL Versus DUAC® Gel Completed NCT02005666 Phase 3
15 WHO Drug Study for Buruli Ulcer - Comparison of SR8 and CR8 Active, not recruiting NCT01659437 Phase 2, Phase 3
16 Leprosy Skin Test Antigens Trial Completed NCT00128193 Phase 2
17 Ciclosporin in the Management of Steroid Resistant Type 1 Reactions in Leprosy Completed NCT00919451 Phase 2
18 Ciclosporin in the Management of Chronic or Recurrent Erythema Nodosum Leprosum Completed NCT00919776 Phase 2
19 Ciclosporin in the Management of New Erythema Nodosum Leprosum Completed NCT00919542 Phase 2
20 Phase II Trial of Peginterferon Alpha-2b and Thalidomide in Adults With Recurrent Gliomas Completed NCT00047879 Phase 2
21 Progression of HIV-Disease Under Low Dose Corticosteroids Completed NCT01299948 Phase 2
22 Virgin Coconut Oil Oral Supplementation for Leprosy Patients Withdrawn NCT01885611 Phase 1, Phase 2
23 Prevention of Disability: Proposal for a Guidance Manual for Leprosy Patients Completed NCT01006759 Phase 1
24 Leprosy Skin Test Antigens Phase 1 Completed NCT01920750 Phase 1
25 Study of the Safety and Immunogenicity of Bacille Calmette Guerin (BCG) Vaccine Completed NCT00654316 Phase 1
26 Measurement of Anti-TB Drugs in Lung Tissue From Patients Having Surgery to Treat Tuberculosis Completed NCT00816426 Phase 1
27 Montelukast in ENL Reaction Unknown status NCT00406861
28 Molecular Epidemiology of Leprosy - Philippines Completed NCT00315809
29 Microcirculatory Impairment in Patients With Leprosy Completed NCT02085317
30 The Use of Low Level Laser Therapy for Wound Healing in Leprosy Patients Completed NCT00860717
31 Molecular and Immunological Tools for Detection of Strain Diversity, Drug Resistance and Immunological Responses Completed NCT00138437
32 Impact of the Virtual Human Project on Team-based Learning: A Randomized-controlled Trial Completed NCT02484469
33 SMF to Improve Performance of Microscopy for the Diagnosis of PTB in a High HIV Prevalence Setting Completed NCT02701439
34 γ-irradiated BCG to Train Innate Immunity Completed NCT02259608
35 Granuloma Annulare Treated With Rifampin, Ofloxacin, and Minocycline Combination Therapy Completed NCT00720980
36 Genetics of Hepatitis C Virus Infection Completed NCT00005657
37 Toll-like Receptor 2 Gene Polymorphism, Serum Cytokines and Susceptibility to Disease Severity or Treatment Response of Pulmonary Tuberculosis Completed NCT00772408
38 Efficacy of Topical Liposomal Form of Drugs in Cutaneous Leishmaniasis Completed NCT01050777 Early Phase 1
39 Self-verification and Support Via Mobile Phones Drastically Improves Tuberculosis Treatment Success in LMIC Settings Completed NCT03135366
40 Low Level Laser Therapy Effects in Peripheral Nerves Patient With Leprosy. Recruiting NCT03072004
41 Extramembranous and Interosseous Technique of Tibialis Posterior Tendon Transfer Recruiting NCT01751503
42 CD8 Reactivity to Microorganisms in Blood and Breast Milk Recruiting NCT03084614
43 Platelet Rich Plasma and Perineural Injection Therapy for Carpal Tunnel Syndrome Recruiting NCT02696161
44 Treatment Protocol for Clofazamine in the Long Term Treatment of Leprosy No longer available NCT00852345
45 Safety and Efficacy of Different Onset Times of Treatment With Pulsed Dye Laser on Improvement of Surgical Scars Terminated NCT00506363
46 Safety and Efficacy of Different Intervals of Pulsed Dye Laser Sessions on Improvement of Surgical Scars Withdrawn NCT00506090

Search NIH Clinical Center for Leprosy

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: leprosy

Genetic Tests for Leprosy

Genetic tests related to Leprosy:

id Genetic test Affiliating Genes
1 Leprosy 2 29
2 Leprosy 3 29

Anatomical Context for Leprosy

MalaCards organs/tissues related to Leprosy:

39
Skin, T Cells, Eye, Testes, Bone, Monocytes, Bone Marrow

The Foundational Model of Anatomy Ontology organs/tissues related to Leprosy:

18
Testes, Skin, Superficial Peripheral Nerves, Mucous Membranes Of The Upper Respiratory Tract, Anterior Chamber Of The Eyes

Publications for Leprosy

Articles related to Leprosy:

(show top 50) (show all 1879)
id Title Authors Year
1
Leprosy case detection campaign (LCDC) for active surveillance. ( 28403695 )
2017
2
HLA Alleles are Genetic Markers for Susceptibility and Resistance towards Leprosy in a Mexican Mestizo Population. ( 28025823 )
2017
3
Global practices in regard to implementation of preventive measures for leprosy. ( 28472183 )
2017
4
Prevalence and risk factors for hepatitis B and C viruses in patients with leprosy. ( 28457830 )
2017
5
Unusual Presentation of Multibacillary Nodular Leprosy. ( 28042219 )
2017
6
Trend of leprosy in individuals under the age of 15 in Mato Grosso (Brazil), 2001-2013. ( 28423139 )
2017
7
Lepromatous leprosy in a renal transplant recipient. ( 28449328 )
2017
8
Feline leprosy due to Candidatus 'Mycobacterium tarwinense'. ( 28438086 )
2017
9
An Employee With Undiagnosed Leprosy: Are Other Employees at Risk? ( 28486035 )
2017
10
Leprosy in Children. ( 28444521 )
2017
11
Magnetic resonance imaging in pure neural leprosy. ( 28478305 )
2017
12
Structural and functional changes in the microcirculation of lepromatous leprosy patients - Observation using orthogonal polarization spectral imaging and laser Doppler flowmetry iontophoresis. ( 28419120 )
2017
13
Further evidence of leprosy in Isle of Wight red squirrels. ( 28432249 )
2017
14
Distinct Roles of Th17 and Th1 Cells in Inflammatory Responses Associated with the Presentation of Paucibacillary Leprosy and Leprosy Reactions Th17 Immune Response in Leprosy. ( 28426172 )
2017
15
Correlation between therapy and lipid profile of leprosy patients: is there a higher risk for developing cardiovascular diseases after treatment? ( 28457229 )
2017
16
Autophagy Is an Innate Mechanism Associated with Leprosy Polarization. ( 28056107 )
2017
17
Interruption of persistent exposure to leprosy combined or not with recent BCG vaccination enhances the response to Mycobacterium leprae specific antigens. ( 28467415 )
2017
18
Severe type 1 upgrading leprosy reaction in a renal transplant recipient: a paradoxical manifestation associated with deficiency of antigen-specific regulatory T-cells? ( 28438129 )
2017
19
History and mysteries of leprosy. ( 28438084 )
2017
20
"I Wasted 3 Years, Thinking It's Not a Problem": Patient and Health System Delays in Diagnosis of Leprosy in India: A Mixed-Methods Study. ( 28081131 )
2017
21
Conjugal leprosy: is there a need for active surveillance in endemic areas? ( 28073313 )
2017
22
Expression of interleukin-1I^ and interleukin-6 in leprosy reactions in patients with human immunodeficiency virus coinfection. ( 28511777 )
2017
23
Endothelium adhesion molecules ICAM-1, ICAM-2, VCAM-1 and VLA-4 expression in leprosy. ( 28088473 )
2017
24
Dermoscopy of histoid leprosy: a case report. ( 28515998 )
2017
25
In Situ complement activation and T-cell immunity in leprosy spectrum: An immunohistological study on leprosy lesional skin. ( 28505186 )
2017
26
Reconstructive Surgery Camp for Leprosy Deformities in a Tertiary Hospital: An Example of Service Delivery at Low Costs. ( 27630868 )
2016
27
Geographic weighted regression: applicability to epidemiological studies of leprosy. ( 27163567 )
2016
28
Leprosy as a Cause of Distal Symmetric Polyneuropathy--Reply. ( 27187311 )
2016
29
Leprosy and bone marrow involvement. ( 28011849 )
2016
30
China's Mars plans, leprosy vaccine and self-driving taxis. ( 27582199 )
2016
31
Leprosy in England and Wales 1953-2012: surveillance and challenges in low incidence countries. ( 27142858 )
2016
32
Association of the solute carrier family 11 member 1 gene polymorphisms with susceptibility to leprosy in a Brazilian sample. ( 26814595 )
2016
33
Leg ulcer in lepromatous leprosy - Case report. ( 27828650 )
2016
34
Factors associated with seropositivity for APGL-Iamong household contacts of leprosy patients. ( 27163568 )
2016
35
Number of leprosy reactions during treatment: clinical correlations and laboratory diagnosis. ( 28001221 )
2016
36
Pauci- and Multibacillary Leprosy: Two Distinct, Genetically Neglected Diseases. ( 27219008 )
2016
37
The GATA3 gene is involved in leprosy susceptibility in Brazilian patients. ( 26807920 )
2016
38
A large-scale genome-wide association and meta-analysis identified four novel susceptibility loci for leprosy. ( 27976721 )
2016
39
Addition of Mycobacterium indicus pranii (MIP) vaccine as an immunotherapeutic with standard chemotherapy in borderline leprosy: A double blind study to assess clinical improvement (A preliminary report). ( 27518926 )
2016
40
Borderline Lepromatous Leprosy: A Case to Remember. ( 26888945 )
2016
41
Genetic variants of the MAVS, MITA and MFN2 genes are not associated with leprosy in Han Chinese from Southwest China. ( 27553710 )
2016
42
Borderline Tuberculoid Leprosy Associated with Histoid Leprosy. ( 27688462 )
2016
43
Temporalis Muscle Transfer for the Treatment of Lagophthalmos in Patients With Leprosy: Refinement in Surgical Techniques to Prevent Postoperative Ptosis. ( 26674897 )
2016
44
Type 1 reaction in leprosy patients corresponds with a decrease in pro-resolving and an increase in pro-inflammatory lipid mediators. ( 27932613 )
2016
45
Nodular melanoma in trophic ulceration of a leprosy patient: a case study. ( 27169340 )
2016
46
Th9 cytokines response and its possible implications in the immunopathogenesis of leprosy. ( 27927694 )
2016
47
The -308 bp TNF gene polymorphism influences tumor necrosis factor expression in leprosy patients in Bahia State, Brazil. ( 26829382 )
2016
48
Consider leprosy as an aetiology of sensory neuronopathy. ( 28006836 )
2016
49
Painless Ulcers and Fissures of Toes: Hereditary Sensory Neuropathy, Not Leprosy. ( 26955138 )
2016
50
Identifying Leprosy and Those at Risk of Developing Leprosy by Detection of Antibodies against LID-1 and LID-NDO. ( 27658042 )
2016

Variations for Leprosy

ClinVar genetic disease variations for Leprosy:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 TLR2 NM_003264.4(TLR2): c.2029C> T (p.Arg677Trp) single nucleotide variant risk factor rs121917864 GRCh37 Chromosome 4, 154626088: 154626088

Copy number variations for Leprosy from CNVD:

7
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 255081 9 72339785 73251640 Duplication TRPM3 Leprosy

Expression for Leprosy

Search GEO for disease gene expression data for Leprosy.

Pathways for Leprosy

Pathways related to Leprosy according to GeneCards Suite gene sharing:

(show top 50) (show all 60)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.05 CD40LG HLA-DRB1 IFNG IL10 IL12RB2 IL18RAP
2
Show member pathways
13.7 CD40LG IFNG IL10 IL12RB2 IL18RAP IL2
3
Show member pathways
13.45 CD40LG IL10 IL12RB2 IL2 IL4 LTA
4
Show member pathways
13.41 CD40LG HLA-DRB1 IFNG IL10 IL12RB2 IL18RAP
5
Show member pathways
13.33 CD40LG IL10 IL12RB2 IL2 IL4 LTA
6
Show member pathways
13.24 HLA-DRB1 IFNG IL2 IL4 TLR1 TLR2
7
Show member pathways
12.94 IFNG IL10 IL2 TLR1 TLR2 TNF
8
Show member pathways
12.91 CD40LG HLA-DRB1 IFNG IL10 IL2 IL4
9
Show member pathways
12.86 HLA-DRB1 IFNG IL2 IL4 LTA TLR2
10
Show member pathways
12.75 CD40LG IL2 LTA TLR1 TLR2 TNF
11
Show member pathways
12.68 CD40LG HLA-DRB1 IFNG IL10 IL12RB2 IL2
12
Show member pathways
12.65 CD40LG LTA TLR1 TLR2 TNF
13
Show member pathways
12.62 IFNG IL10 IL18RAP IL2 TNF
14 12.53 CD40LG IFNG IL10 IL2 IL4 TLR1
15
Show member pathways
12.51 CD40LG IFNG IL10 IL2 IL4 TNF
16 12.44 HLA-DRB1 IL2 LTA TNF
17
Show member pathways
12.35 IFNG IL2 IL4 TNF
18
Show member pathways
12.35 IFNG IL4 TLR2 TNF
19
Show member pathways
12.28 IFNG IL10 IL12RB2 IL2 IL4
20
Show member pathways
12.27 CD40LG HLA-DRB1 IFNG IL10 IL4 TLR2
21
Show member pathways
12.25 IFNG IL4 TLR1 TLR2 TNF
22 12.22 IFNG TLR1 TLR2 TNF
23
Show member pathways
12.22 IFNG IL10 IL2 IL4 LTA TNF
24
Show member pathways
12.19 HLA-DRB1 IFNG IL10 IL12RB2 IL18RAP IL2
25 12.18 HLA-DRB1 IFNG IL10 MRC1 NOD2 TLR1
26 12.08 IFNG IL10 IL2 IL4 TNF
27 12.06 IFNG IL2 IL4 TNF
28
Show member pathways
12.01 HLA-DRB1 IFNG IL12RB2 IL18RAP IL2 IL4
29
Show member pathways
11.98 IFNG IL4 TLR1 TLR2
30 11.95 IFNG IL10 TLR2 TNF
31 11.92 HLA-DRB1 IFNG TLR2 TNF
32
Show member pathways
11.85 CD40LG IFNG IL2 IL4 TNF
33 11.83 MRC1 TLR1 TLR2
34
Show member pathways
11.83 CD40LG LTA TNF
35 11.83 IFNG IL10 IL2 TNF
36 11.81 IFNG IL2 IL4
37 11.77 IFNG IL10 IL12RB2 IL2
38 11.73 CD40LG IL10 IL4 LTA
39
Show member pathways
11.73 CD40LG IFNG IL2 TNF
40 11.73 CD40LG IL10 IL4 LTA TLR2 TNF
41
Show member pathways
11.71 IL2 IL4 LTA
42 11.7 IFNG IL10 IL12RB2 IL2 IL4 LTA
43
Show member pathways
11.67 IFNG IL2 TNF
44 11.6 CD40LG IFNG IL10 TLR2 TNF
45 11.59 IFNG IL2 TNF
46
Show member pathways
11.57 IFNG LTA TNF
47 11.56 IL10 IL4 TNF
48 11.56 IFNG IL10 IL12RB2 IL2 IL4
49 11.55 IFNG IL2 TNF
50 11.55 IFNG TLR2 TNF

GO Terms for Leprosy

Cellular components related to Leprosy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.73 CD40LG HLA-DRB1 MRC1 NOD2 TLR2 TNF
2 phagocytic vesicle membrane GO:0030670 9.26 RAB32 SLC11A1 TLR1 TLR2
3 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 9.16 TLR1 TLR2
4 external side of plasma membrane GO:0009897 9.1 CD40LG HLA-DRB1 IFNG IL12RB2 IL4 TNF

Biological processes related to Leprosy according to GeneCards Suite gene sharing:

(show top 50) (show all 55)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of protein phosphorylation GO:0001934 9.96 IFNG IL2 IL4 TNF
2 inflammatory response GO:0006954 9.95 CD40LG IL10 IL18RAP SLC11A1 TLR1 TLR2
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.92 CD40LG NOD2 TLR2 TNF
4 cellular response to lipopolysaccharide GO:0071222 9.92 IFNG IL10 MRC1 TNF
5 response to lipopolysaccharide GO:0032496 9.92 IL10 IL12RB2 LTA SLC11A1 TLR2
6 response to nutrient GO:0007584 9.88 IL4 LTA NOD2
7 defense response to Gram-positive bacterium GO:0050830 9.87 LTA TLR2 TNF
8 B cell differentiation GO:0030183 9.87 CD40LG IL10 IL4
9 humoral immune response GO:0006959 9.85 IFNG LTA TNF
10 antigen processing and presentation GO:0019882 9.85 HLA-DRB1 IFNG RAB32
11 defense response to bacterium GO:0042742 9.85 IFNG IL10 NOD2 SLC11A1 TLR1 TNF
12 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.84 IFNG IL2 IL4
13 positive regulation of tumor necrosis factor production GO:0032760 9.84 IFNG NOD2 TLR2
14 positive regulation of interleukin-6 production GO:0032755 9.82 NOD2 TLR2 TNF
15 positive regulation of T cell proliferation GO:0042102 9.81 CD40LG IFNG IL2 IL4
16 positive regulation of interleukin-8 production GO:0032757 9.75 NOD2 TLR2 TNF
17 negative regulation of nitric oxide biosynthetic process GO:0045019 9.72 IL10 IL4
18 response to molecule of bacterial origin GO:0002237 9.72 IL10 TLR2
19 positive regulation of interleukin-17 production GO:0032740 9.71 IL2 NOD2
20 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.71 IL10 TNF
21 regulation of cytokine secretion GO:0050707 9.71 TLR1 TLR2
22 positive regulation of interleukin-12 production GO:0032735 9.71 CD40LG IFNG TLR2
23 macrophage activation GO:0042116 9.7 SLC11A1 TLR1
24 detection of bacterium GO:0016045 9.69 HLA-DRB1 NOD2
25 cellular response to unfolded protein GO:0034620 9.69 PACRG PRKN
26 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.69 IFNG TLR1
27 endothelial cell apoptotic process GO:0072577 9.68 IL10 TNF
28 positive regulation of dendritic cell antigen processing and presentation GO:0002606 9.68 NOD2 SLC11A1
29 negative regulation of cytokine secretion involved in immune response GO:0002740 9.67 IL10 TNF
30 type 2 immune response GO:0042092 9.67 IL10 IL4
31 positive regulation of chemokine biosynthetic process GO:0045080 9.67 IFNG IL4 TNF
32 regulation of immunoglobulin secretion GO:0051023 9.65 CD40LG TNF
33 positive regulation of isotype switching to IgG isotypes GO:0048304 9.65 IFNG IL2 IL4
34 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.64 LTA TNF
35 regulation of isotype switching GO:0045191 9.64 IL10 IL4
36 negative regulation of T-helper 17 cell differentiation GO:2000320 9.63 IL2 IL4
37 positive regulation of mononuclear cell migration GO:0071677 9.63 IL4 TNF
38 positive regulation of interleukin-10 production GO:0032733 9.62 CD40LG IL4 NOD2 TLR2
39 receptor biosynthetic process GO:0032800 9.61 IL10 TNF
40 cytokine secretion involved in immune response GO:0002374 9.61 NOD2 TLR2
41 positive regulation of MHC class II biosynthetic process GO:0045348 9.61 IFNG IL10 IL4
42 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.6 IFNG TNF
43 cellular response to triacyl bacterial lipopeptide GO:0071727 9.59 TLR1 TLR2
44 toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 9.58 TLR1 TLR2
45 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 9.57 LTA TNF
46 positive regulation of vitamin D biosynthetic process GO:0060557 9.56 IFNG TNF
47 defense response to protozoan GO:0042832 9.56 IFNG IL10 IL4 SLC11A1
48 detection of triacyl bacterial lipopeptide GO:0042495 9.55 TLR1 TLR2
49 negative regulation of growth of symbiont in host GO:0044130 9.46 IFNG IL10 LTA TNF
50 immune response GO:0006955 9.4 CD40LG HLA-DRB1 IFNG IL10 IL18RAP IL2

Molecular functions related to Leprosy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 receptor activity GO:0004872 9.62 IL18RAP MRC1 TLR1 TLR2
2 peptidoglycan binding GO:0042834 9.37 NOD2 TLR2
3 Hsp70 protein binding GO:0030544 9.33 NOD2 PACRG PRKN
4 lipopeptide binding GO:0071723 9.26 TLR1 TLR2
5 cytokine activity GO:0005125 9.17 CD40LG IFNG IL10 IL2 IL4 LTA
6 tumor necrosis factor receptor binding GO:0005164 9.13 CD40LG LTA TNF

Sources for Leprosy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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