MCID: LPR003
MIFTS: 67

Leprosy malady

Infectious, Neuronal categories

Summaries for Leprosy

Sources:
8Disease Ontology, 3CDC, 64Wikipedia, 47OMIM, 33MalaCards
See all sources

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Export this MalaCard
Disease Ontology:8 A primary bacterial infectious disease that results in infection located in superficial peripheral nerves, located in skin, located in mucous membranes of the upper respiratory tract, located in anterior chamber of the eyes, or located in testes, has material basis in mycobacterium leprae, which is transmitted by aerosol spread from infected nasal secretions to exposed nasal and oral mucosa. the infection has symptom skin lesions, has symptom sensory loss, has symptom motor loss and has symptom eye damage.

MalaCards: Leprosy, also known as leprosy, susceptibility to, is related to lepromatous leprosy and tuberculoid leprosy, and has symptoms including skin lesions, sensory loss and motor loss. An important gene associated with Leprosy is TLR2 (toll-like receptor 2), and among its related pathways are Akt Signaling and IL27-mediated signaling events. The drug thalidomide and the compounds ionomycin and il 10 have been mentioned in the context of this disorder. Affiliated tissues include superficial peripheral nerves, skin and mucous membranes of the upper respiratory tract, and related mouse phenotypes are immune system and hematopoietic system.

CDC:3 Hansen's disease (also known as leprosy) is a long-lasting infection caused by bacteria.

Wikipedia:64 Leprosy, also known as Hansen\'s disease (HD), is a chronic infection caused by the bacterium... more...

Description from OMIM:47 246300, 607572, 609888, 610988, 613223 613407 more

Aliases & Classifications for Leprosy

Sources:
8Disease Ontology, 47OMIM, 10DISEASES, 49Orphanet, 61UMLS, 9diseasecard, 27ICD9CM, 40NCIt, 57SNOMED-CT, 35MeSH, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious
Anatomical: Neuronal


Aliases & Descriptions:

leprosy 8 47 10 49 61
leprosy, susceptibility to 9


External Ids:

Disease Ontology8 DOID:1024
ICD9CM27 030.9, 030
NCIt40 C84824
MeSH35 D007918
MESH via Orphanet36 D007918
ICD10 via Orphanet26 A30
SNOMED-CT via Orphanet58 81004002
UMLS via Orphanet62 C0023343
ICD1025 A30, A30.9

Related Diseases for Leprosy

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Leprosy family:

leprosy 5 leprosy 4

Diseases related to Leprosy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 296)
idRelated DiseaseScoreTop Affiliating Genes
1lepromatous leprosy31.8IL2, IL4, IL10, LTA, IFNG, TLR2
2tuberculoid leprosy31.5IL2RA, IFNG, IL10
3tuberculosis30.8TNF, SLC11A1, IL2RA, IL10, IL12B, IL12RB1
4pulmonary tuberculosis30.4IL2, IL4, IL12RB1, IL12B, IL10, IL2RA
5arthritis30.2LTA, TLR2, IFNG, IL4, SLC11A1, IL10
6tetanus30.2IL2, IL10, IL4, TLR2, IFNG, IL2RA
7hepatitis c30.2IL2, IL4, IL12B, IL10, IFNG, TLR2
8hepatitis b30.2TLR2, IFNG, IL2RA, IL12B, IL10
9cutaneous leishmaniasis30.2IL10, IFNG
10systemic lupus erythematosus30.1IL4, TLR2, IL12RB1, IL12B, IL10, IL2RA
11atopy29.9IL12RB2, LTA, IFNG, TLR2, IL10, IL12B
12uveitis29.9IL2RA, IFNG, LTA, IL10, TNF, IL4
13mycosis fungoides29.9IL2RA, IL2
14crohn's disease29.9TNF
15vasculitis29.9TNF
16sepsis29.7IL10, LTA, TLR2, TLR1, TNF, DEFB1
17periapical granuloma29.7IL2RA, IL4
18paracoccidioidomycosis29.7IL10
19alopecia areata29.7IFNG
20parkinson's disease29.7PACRG, PARK2
21acquired immunodeficiency syndrome29.7IL2
22anaplastic large cell lymphoma29.7IL2RA
23thymoma29.7CD2, IL2
24borderline leprosy11.0
25indeterminate leprosy10.7
26hansen's disease10.5
27foot drop10.4
28syphilis10.3
29molluscum contagiosum10.2
30amyloidosis10.2
31amyloidosis, secondary10.2
32chromoblastomycosis10.2
33mononeuritis multiplex10.1
34n syndrome10.1
35dysautonomia10.1
36antiphospholipid syndrome10.1
37proliferative glomerulonephritis10.1
38chronic rhinitis10.1
39rhinosporidiosis10.1
40secondary syphilis10.1
41leprosy 510.1
42ipex syndrome10.0TLR2, IFNG, IFNGR1, TNF, LTA, CD2
43viral infectious disease10.0IL2RA, CD2, LTA, TNF, IFNGR1, IFNG
44sarcoidosis10.0IL2RA, LTA, DEFB1, TNF, IFNGR1, IFNG
45rheumatoid arthritis10.0SLC11A1, IL2, IL4, IL2RA, TLR2, IFNG
46multiple sclerosis10.0IL12B, IL4, IL10, IL2RA, IFNG, IFNGR1
47atopic dermatitis10.0IL2, IL4, IL12RB1, IL12B, IL10, IL2RA
48allergic asthma10.0IL4, IL12RB1, IL10, IL12RB2, IL2RA, LTA
49leukemia10.0IL4, IL2, PARK2, IL12B, TLR2, IFNG
50psoriasis10.0IL2, IL4, IL12B, IL10, IL2RA, LTA

Graphical network of the top 20 diseases related to Leprosy:



Diseases related to leprosy

Clinical Features for Leprosy

Sources:
47OMIM, 8Disease Ontology
See all sources

Clinical features from OMIM:

246300,607572,609888,610988,613223,613407

Clinical synopsis from OMIM:

246300

Symptoms:

8 (see all 4)
  • skin lesions
  • sensory loss
  • motor loss
  • eye damage

Drugs & Therapeutics for Leprosy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Leprosy

Drug clinical trials:

Search ClinicalTrials for Leprosy

Search NIH Clinical Center for Leprosy

Search CenterWatch for Leprosy

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Leprosy

Anatomical Context for Leprosy

Sources:
14FMA
See all sources

FMA organs/tissues related to Leprosy:

14
Superficial peripheral nerves, Skin, Mucous membranes of the upper respiratory tract, Anterior chamber of the eyes, Testes

Animal Models for Leprosy or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Leprosy

Sources:
51PubMed
See all sources

Articles related to Leprosy:

(show top 50)    (show all 1646)
idTitleAuthorsYear
1
Mycobacterium leprae is identified in the oral mucosa from paucibacillary and multibacillary leprosy patients. (23473290)
2014
2
World Leprosy Day: where does Iran stand? (23351809)
2013
3
Non-trophic cutaneous ulcers in lepromatous leprosy. (24306029)
2013
4
A comparison of stigma among patients with leprosy in rural Tanzania and urban United States: a role for public health in dermatology. (23451850)
2013
5
Lepromatous leprosy with an uncommon presentation: a case report. (24046912)
2013
6
Role of CD8(+) T cells in triggering reversal reaction in HIV/leprosy patients. (23566249)
2013
7
A study of standardized regimens of steroid treatment in reactions in leprosy at a referral centre. (23077778)
2012
8
Nerve damage in leprosy: a continuing challenge to scientists, clinicians and service providers. (24029146)
2012
9
Leprosy in Buriticupu, state of MaranhALo: active search in the general population. (22534992)
2012
10
Borderline tuberculoid leprosy associated with primary cutaneous histoplasmosis. (22481668)
2012
11
Persisting leprosy transmission despite increased control measures in an endemic cluster in Brazil: the unfinished agenda. (23614252)
2012
12
Florid reactive periostitis ossificans of long bones and digits associated with reaction in a patient with leprosy. (22655475)
2012
13
The immunological skin tests in leprosy. Part III. The isolated protein antigen in relation to the antigens used by other workers. 1942. (23210151)
2012
14
Generalized eruptive histiocytosis mimicking leprosy. (21727699)
2011
15
Association of TNF, MBL, and VDR polymorphisms with leprosy phenotypes. (20650301)
2010
16
Potential plasma markers of Type 1 and Type 2 leprosy reactions: a preliminary report. (19473542)
2009
17
Val247Leu polymorphism of beta2 glycoprotein 1 gene may justify the genesis of anti beta2GP1 antibodies and antiphospholipid syndrome in multibacillary leprosy]. (19851667)
2009
18
Clinico-mycological profile of dermatophytosis in a reference centre for leprosy and dermatological diseases in Addis Ababa. (16482389)
2006
19
Histopathological study of apparently normal oral mucosa in lepromatous leprosy. (16375230)
2005
20
Borderline tuberculoid leprosy localised over a scar. (16044818)
2005
21
Lepromatous leprosy with extensive unusual ulcerations and cachexia. Is it the first case of Lucio's phenomenon from Iran? (15217312)
2004
22
Lepromatous leprosy and reversal reaction in a Micronesian immigrant. (14636206)
2003
23
Expression of cyclooxygenase type 2 in lepromatous and tuberculoid leprosy lesions. (12752141)
2003
24
Concomitant infection with pulmonary tuberculosis and lepromatous leprosy. (12974444)
2003
25
Ocular complications in newly diagnosed borderline lepromatous and lepromatous leprosy patients: baseline profile of the Indian cohort. (12446359)
2002
26
Localized linear lesions in lepromatous leprosy. (11898466)
2001
27
Sequential erythema nodosum leprosum and reversal reaction with similar lesional cytokine mRNA patterns in a borderline leprosy patient. (11167702)
2001
28
Expression of inducible nitric oxide synthase and nitrotyrosine in borderline leprosy lesions. (11736907)
2001
29
Association of NRAMP1 polymorphism with leprosy type but not susceptibility to leprosy per se in west Africans. (11791966)
2001
30
Delay in diagnosis: indeterminate leprosy presenting with rheumatic manifestations. (10689224)
2000
31
High prevalence of vitiligo in lepromatous leprosy. (11123444)
2000
32
Lagophthalmos in leprosy. (9598404)
1998
33
Chromoblastomycosis simulating lepromatous leprosy. (9614844)
1998
34
Diffuse alopecia of the scalp in borderline-lepromatous leprosy in an Indian patient. (9503871)
1997
35
Tibialis posterior transfer for the correction of foot drop in leprosy. Long-term outcome. (8898128)
1996
36
Involvement of lips and gums in a borderline tuberculoid leprosy patient. (9001905)
1996
37
A clinical trial of minocycline in lepromatous leprosy. (1737148)
1992
38
Vitiligo and lepromatous leprosy. (2030309)
1991
39
Immunological upgrading with combined immunotherapy and chemotherapy in a lepromatous leprosy patient: a case report. (1795588)
1991
40
Quantitation of the soluble E-receptor of human T lymphocytes by rocket electrophoresis in the serum of patients with lepromatous and tuberculoid leprosy. (1820499)
1991
41
Immunohistologic assessment of cytokine production of infiltrating cells in various forms of leprosy. (2121040)
1990
42
CD1-positive epidermal Langerhans cells in regressed tuberculoid and lepromatous leprosy lesions. (1700968)
1990
43
Significant enhanced superoxide anion (O2-) production in vitro by peripheral blood monocytes of lepromatous leprosy patients stimulated with liposome and suppression by C-reactive protein (CRP). (3035044)
1986
44
Relationship between the loss of maxillary anterior alveolar bone and the duration of untreated lepromatous leprosy in Malaysia. (3990507)
1985
45
Inhibition of antibody-dependent, cell-mediated cytotoxicity by serum from lepromatous leprosy patients. (4020209)
1985
46
Defective production of monocyte-activating cytokines in lepromatous leprosy. (6366107)
1984
47
Serum enzyme profile in tuberculoid leprosy. (7098444)
1982
48
Some aspects of tuberculoid leprosy and chemotherapeutic trials. (116471)
1979
49
Mycobacterium leprae in the striated muscle of tuberculoid leprosy patients. (359926)
1978
50
LOW-RESISTANT TUBERCULOID LEPROSY. (14261287)
1964

Genetic Variations for Leprosy

Expression for genes affiliated with Leprosy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Leprosy

Search GEO for disease gene expression data for Leprosy.

Pathways for genes affiliated with Leprosy

Sources:
52QIAGEN, 38NCBI BioSystems Database, 53R&D Systems, 30KEGG, 54Reactome, 12EMD Millipore, 56SinoBiological, 60Tocris Bioscience
See all sources

Pathways related to Leprosy according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.1IL12B, IL2, IL4, IL12RB1, IL10, IL12RB2
2
Hide members
11.1TLR2, IL12RB1, TLR1, IFNGR2, IFNG, IL2
3
Hide members
11.1IL4, IL12RB1, IL12B, IL10, LTA, TNF
4
Hide members
11.0IFNGR2, TLR2, IL2, IL12B, TNF, IFNG
511.0IFNGR2, IL12RB1, IL4, IL2, IFNG, IFNGR1
6
Hide members
11.0IL2RA, TLR1, IL2, TNF, IFNG, IFNGR1
7
Hide members
11.0IFNGR1, TLR2, IL2, IL10, TNF, IFNG
810.9IL12B, IFNGR1, TLR2, TLR1, IL10, TNF
9
Hide members
10.9DEFB1, IFNGR2, TLR1, IL2RA, IFNG, TLR2
1010.9IFNG, TNF, LTA, IL10, IL12B, IL4
11
Hide members
10.9IL12RB2, IL2RA, IL2, IL4, IL12RB1, IL12B
12
Hide members
10.9IL12B, IL2, IL12RB1, IL12RB2, IL2RA, CD2
13
Immune response Bacterial infections in normal airways
10.8IFNGR2, IFNG, IFNGR1, TLR2, TNF, TLR1
1410.8TLR2, TLR1, IFNGR2, IFNG, TNF, IFNGR1
15
Hide members
10.8IL12RB2, IL2RA, CD2, LTA, IL12B, IL12RB1
16
Development PDGF signaling via STATs and NF-kB
Hide members
10.8TNF, IL12RB1, IL2, IFNG, IL10, IL12B
17
Hide members
10.8TLR2, IFNGR2, IFNGR1, IL12RB2, IL12B, IL12RB1
18
Hide members
10.8TNF, IL4, IFNGR1, IFNG, IFNGR2, IL2
19
Hide members
10.8IL12RB1, IL12RB2, IL2RA, CD2, IFNGR1, IFNGR2
20
Hide members
10.8TLR2, TLR1, TNF, LTA, IL12B
2110.8LTA, IL10, IL2, IFNG, IL4
2210.8IL12B, TLR2, IFNG, IL10, TNF
23
Hide members
10.8IL4, LTA, TNF, IL2, IL2RA
24
Hide members
10.8IL2, IL10, IL2RA, TNF, IFNG
25
Hide members
10.7IL2, IL4, IL2RA, TNF, IFNG
26
Hide members
10.7IL12RB1, IL12B, IL12RB2, CD2, LTA
2710.7IL12RB2, IL12RB1, IL2RA, IFNG, IL12B
2810.7IL2, IL12RB1, IL12B, IL2RA, IL12RB2
29
Hide members
10.7IFNGR2, IFNG, IFNGR1, TNF, LTA
30
Hide members
10.7IL2, IFNGR2, IFNG, IFNGR1, IL2RA
31
Hide members
10.7TLR2, TLR1, TNF, LTA
32
Hide members
10.7TLR2, TLR1, TNF, LTA
33
Hide members
10.7TLR2, TLR1, IL2RA, IL2
34
Hide members
10.7IL2RA, IL4, IL2, LTA
3510.7TLR2, TNF, IL12B, IFNG
3610.7IFNG, IL2RA, IL4, IL2
37
Hide members
10.7TNF, IFNG, IFNGR1, LTA
3810.7IL2, IL2RA, TNF, IFNG
3910.7IL10, IL12B, TNF, IFNG
4010.7CD2, TNF, IL2RA, IL4
41
Hide members
10.7IFNGR2, IFNG, IFNGR1, TNF
4210.7TNF, IFNGR2, IFNG, IFNGR1
43
Hide members
10.6IFNG, IL2, IL4
4410.6IFNG, IL2, IL2RA
4510.6IL2, TNF, IFNG
4610.6TNF, IL4, IL2
4710.6IFNGR1, IFNG, IFNGR2
48
Hide members
10.6TLR1, IL12RB1
4910.5TLR2
5010.5IL12B

Compounds for genes affiliated with Leprosy

Sources:
45Novoseek, 60Tocris Bioscience, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 2BitterDB
See all sources

Compounds related to Leprosy according to GeneCards/GeneDecks:

(show top 50)    (show all 96)
idCompoundScoreTop Affiliating Genes
1ionomycin4511.5LTA, CD2, IL2RA, IL10, IL12RB1, IL4
2il 104511.4LTA, TNF, IFNG, IL2, IL4, IL12B
3rantes4511.4TNF, TLR2, IFNG, LTA, IL12B, IL4
4calcitriol45 60 11 2414.3LTA, TLR2, IL2, IFNG, IL4, IL10
5okt34511.3IL2, IL4, IL10, IFNG, IL2RA, LTA
6il-124511.3IL10, IL4, IL2, IL12RB1, IL12B, TNF
7polyinosinic-polycytidylic acid4511.3IL12B, IFNG, TLR2, IL4, IL2, TNF
8neopterin4511.3LTA, IFNG, IL2, IL4, TNF, IL2RA
9tacrolimus45 50 1113.3IL2RA, IL2, IL4, IL10, TNF, IFNG
10imiquimod45 29 60 1114.2TLR2, TLR1, TNF, IL12B, IL10, IFNG
11polymyxin b4511.2IL10, DEFB1, TNF, IFNG, IL4, TLR2
12lipoteichoic acid4511.2TLR2, TNF, LTA, IL10, IL12B, TLR1
13con a4511.2IL4, IL2, IL10, IFNG, CD2, IL2RA
14infliximab45 50 1113.2LTA, IL2RA, IL10, IFNG, IL4, TNF
15interferon gamma4511.2TNF, IFNG, IL10, IL4, IL2
16histamine45 29 2413.2IL10, IL2, IL2RA, TNF, IFNG, TLR2
17vegf4511.2IL10, TLR2, TNF, PARK2, IL2RA, LTA
18herbimycin a45 6012.1TNF, IL2, IL4, IL2RA, LTA, IFNG
192,5-oligoadenylate4511.1TNF, IL2, IL2RA, IFNG, IL10
20nitric oxide45 11 2413.1PARK2, IFNG, LTA, IL10, IL12B, SLC11A1
21poly(i-c)4511.1IFNG, TLR2, TNF, IL12B, IL4
22peptidoglycan45 2912.1TLR2, TLR1, TNF, IL10, IL12B
23cyclosporin a45 29 6013.1IL2RA, IFNG, LTA, CD2
24thymidine45 2412.1IL2, IL4, IL10, TNF, IFNG, IL2RA
25pentoxifylline45 1112.1IL4, LTA, IL12B
26alpha-galactosylceramide4511.1IFNG, IL10, IL2, IL4
27ifn-alpha4511.1IFNG, PARK2, IL2RA, IL10, IL2
28toxin-14511.1TNF, IL2, LTA, IL10
29dexamethasone45 50 29 1114.0TLR2, LTA, DEFB1
30gold sodium thiomalate4511.0IFNG, TNF, IL2RA, IL2
31glatiramer acetate45 1112.0IL2, IL10, IFNG, IL4
32gm-csf45 2912.0IL10, TNF, IFNG
33thalidomide45 50 60 1114.0IL2, IFNG, IL2RA, IL10, TNF
34sb 20358045 6012.0IL4, IL12B, TNF, IFNG, TLR2, IL10
35tyrosine4511.0IL4, IL2, LTA, PARK2, IL12RB1, IL2RA
36chloroquine45 2 50 29 1115.0TNF, IL2RA, IL10, IL4, IL2
37natalizumab45 1112.0IL10, IL2RA, TNF, IFNG
38vitamin d4511.0LTA, IL10, SLC11A1, IL2RA, TLR2, IL12B
395 aminosalicylic acid4511.0IL10, IL2RA, TNF, IL12B
40prednisolone45 29 1113.0LTA, IL2RA
41ivig4510.9IFNG
42pge24510.9IL2
43betaseron4510.9IL10, IFNG, IL4
44cycloheximide4510.9TLR2, LTA
45etanercept45 50 1112.8TNF, LTA, IL10, IFNG
46simvastatin45 50 60 29 11 2415.8TLR2, IFNG, TNF, IL10, IL4
47mycophenolate mofetil45 50 1112.8IL2, IL10, IL2RA, IFNG
48ribavirin45 50 1112.7IL2, IL4, IFNG, IL10
49c-d4t4510.5IL2, IL2RA, IL4
50tarc4510.4IL4, IFNG, TNF, IL10

GO Terms for genes affiliated with Leprosy

Sources:
16Gene Ontology
See all sources

Cellular components related to Leprosy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.9IL4, IL12RB1, IL12RB2, IL2RA, CD2, TNF
2integral to plasma membraneGO:00588710.8TLR2, TLR1, IFNGR1, TNF, CD2, IL12RB2
3Toll-like receptor 1-Toll-like receptor 2 protein complexGO:03535410.6TLR1, TLR2
4extracellular spaceGO:00561510.6IL2, IFNG, TNF, LTA, IL10, IL12B

Biological processes related to Leprosy according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interferon-gamma productionGO:03272911.3IL12B, LTA, IL12RB2, IL2, IL12RB1, SLC11A1
2positive regulation of transcription from RNA polymerase II promoterGO:04594411.3IL4, IL10, TNF, IFNG, TLR2, SLC11A1
3negative regulation of growth of symbiont in hostGO:04413011.3IFNG, TNF, IL10, LTA, IL12B, TLR2
4immune responseGO:00695511.2IL4, IL2, IL2RA, DEFB1, TLR2, TLR1
5positive regulation of activated T cell proliferationGO:04210411.2IL2, IL4, IL12RB1, IL12B, IL2RA
6cell surface receptor signaling pathwayGO:00716611.2IL2RA, CD2, IL12RB2, IFNGR2, IFNG
7cytokine-mediated signaling pathwayGO:01922111.2IFNGR2, IL12RB1, IFNG, IFNGR1, IL12RB2
8defense response to protozoanGO:04283211.1IL4, SLC11A1, IFNG, IL12B
9response to drugGO:04249311.1IL10, IL4, IFNG, TNF, LTA
10inflammatory responseGO:00695411.1TLR2, IL10, TNF, TLR1, SLC11A1
11defense response to bacteriumGO:04274211.1IL10, DEFB1, IFNG, SLC11A1
12positive regulation of isotype switching to IgG isotypesGO:04830411.1IL2, IL4, IFNG
13positive regulation of MHC class II biosynthetic processGO:04534811.1IL4, IL10, IFNG
14negative regulation of interleukin-17 productionGO:03270011.1TLR2, IFNG, IL12B
15positive regulation of chemokine biosynthetic processGO:04508011.1TNF, IL4, IFNG
16apoptotic processGO:00691511.1TNF, CD2, IFNG, IL2RA, LTA, TLR2
17positive regulation of T-helper 1 type immune responseGO:00282711.1IL12B, IL12RB1, SLC11A1
18positive regulation of osteoclast differentiationGO:04567211.1IFNG, IL12B, TNF
19positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252311.1IL2, IL4, IL12B
20regulation of interferon-gamma-mediated signaling pathwayGO:06033411.1IFNGR2, IFNG, IFNGR1
21natural killer cell activationGO:03010111.1CD2, IL12B, IL2
22positive regulation of NF-kappaB import into nucleusGO:04234611.0TNF, IL12B, TLR2
23protein import into nucleus, translocationGO:00006011.0IFNG, TNF, SLC11A1
24positive regulation of interleukin-12 productionGO:03273511.0TLR2, IL12B, IFNG
25response to virusGO:00961511.0TNF, IFNGR1, IFNGR2, IFNG
26positive regulation of cytokine secretionGO:05071511.0TLR2, IL10, TNF
27positive regulation of nitric oxide biosynthetic processGO:04542911.0TNF, TLR2, IFNG
28positive regulation of tumor necrosis factor productionGO:03276011.0IL12B, IFNG, TLR2
29regulation of T cell homeostatic proliferationGO:04601311.0IL2, IL2RA
30cellular response to triacyl bacterial lipopeptideGO:07172711.0TLR2, TLR1
31positive regulation of vitamin D biosynthetic processGO:06055711.0IFNG, TNF
32positive regulation of chronic inflammatory response to antigenic stimulusGO:00287611.0LTA, TNF
33detection of triacyl bacterial lipopeptideGO:04249510.9TLR1, TLR2
34defense response to Gram-positive bacteriumGO:05083010.9TLR2, TNF, LTA
35regulation of isotype switchingGO:04519110.9IL4, IL10
36humoral immune responseGO:00695910.9LTA, TNF, IFNG
37positive regulation of calcidiol 1-monooxygenase activityGO:06055910.9IFNG, TNF
38detection of diacyl bacterial lipopeptideGO:04249610.9TLR1, TLR2
39receptor biosynthetic processGO:03280010.9TNF, IL10
40positive regulation of T cell proliferationGO:04210210.8IFNG, IL4, IL12B
41positive regulation of inflammatory responseGO:05072910.8IL2, IL12B, TLR2
42positive regulation of T-helper 17 cell lineage commitmentGO:200033010.8IL12RB1, IL12B
43type 2 immune responseGO:04209210.8IL10, IL4
44positive regulation of memory T cell differentiationGO:04338210.7IL12B, IL12RB1
45negative regulation of cytokine secretion involved in immune responseGO:00274010.7TNF, IL10
46positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.7LTA, TNF
47positive regulation of smooth muscle cell apoptotic processGO:03439310.6IL12B, IFNG
48positive regulation of T-helper 17 type immune responseGO:200031810.6IL12B, IL12RB1
49positive regulation of tissue remodelingGO:03410510.5IL2, IL12B
50positive regulation of interleukin-6 biosynthetic processGO:04541010.3IFNG, TLR1

Molecular functions related to Leprosy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.9LTA, IFNG, TNF, IL10, IL2, IL4
2cytokine receptor activityGO:00489610.6IL12RB1, IL12RB2, IL12B
3interleukin-12 receptor bindingGO:00514310.6IL12RB1, IL12B
4interferon-gamma receptor activityGO:00490610.5IFNGR2, IFNGR1
5growth factor activityGO:00808310.4IL12B, IL4, IL2, IL10

Products for genes affiliated with Leprosy

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Leprosy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet