MCID: LPR003
MIFTS: 78

Leprosy malady

Infectious diseases, Neuronal diseases, Reproductive diseases, Rare diseases, Skin diseases, Eye diseases categories
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Summaries for Leprosy

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Disease Ontology:8 A primary bacterial infectious disease that results in infection located in superficial peripheral nerves, located in skin, located in mucous membranes of the upper respiratory tract, located in anterior chamber of the eyes, or located in testes, has material basis in mycobacterium leprae, which is transmitted by aerosol spread from infected nasal secretions to exposed nasal and oral mucosa. the infection has symptom skin lesions, has symptom sensory loss, has symptom motor loss and has symptom eye damage.

MalaCards based summary: Leprosy, also known as leprosy, susceptibility to, is related to tuberculoid leprosy and lepromatous leprosy, and has symptoms including An important gene associated with Leprosy is TLR2 (toll-like receptor 2), and among its related pathways are IL4-mediated signaling events and Defensins. The drug thalidomide and the compounds alpha-galactosylceramide and toxin-1 have been mentioned in the context of this disorder. Affiliated tissues include superficial peripheral nerves, skin and mucous membranes of the upper respiratory tract, and related mouse phenotypes are no phenotypic analysis and renal/urinary system.

Wikipedia:65 Leprosy, also known as Hansen\'s disease (HD), is a chronic infection caused by the bacteria... more...

Descriptions from OMIM:46 609888, 246300, 613407, 607572, 610988 613223 more

Aliases & Classifications for Leprosy

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Sources:
8Disease Ontology, 9diseasecard, 46OMIM, 10DISEASES, 48Orphanet, 62UMLS, 57SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt, 26ICD10 via Orphanet, 63UMLS via Orphanet, 35MESH via Orphanet, 25ICD10
See all sources

Leprosy, Aliases & Descriptions:

Name: Leprosy 8 46 10 48 62
 
Leprosy, Susceptibility to 9


Classifications:



External Ids:

Disease Ontology8 DOID:1024
MeSH34 D007918
ICD9CM27 030, 030.9
NCIt39 C84824
ICD10 via Orphanet26 A30.3, A30.4, A30.5 A30.8, A30.9, A30.0, A30.1, A30.2, more
UMLS via Orphanet63 C0023343
MESH via Orphanet35 D007918
ICD1025 A30, A30.9

Related Diseases for Leprosy

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Diseases in the Leprosy family:

Leprosy 5 Leprosy 4

Diseases related to Leprosy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 292)
idRelated DiseaseScoreTop Affiliating Genes
1tuberculoid leprosy32.0IL10, IL2RA, IFNG
2lepromatous leprosy31.8TLR2, IFNG, IL4, IL2, IL10, LTA
3filariasis30.8TLR2
4cutaneous leishmaniasis30.7IFNG, IL10
5aspergillosis30.4TLR2, IFNG
6periapical granuloma30.3IL4, IL2RA
7leishmaniasis30.3IFNGR1, IFNG, IL4, IL10, SLC11A1
8hepatitis c30.2TLR2, IFNG, IL10, IL12B
9arthritis30.1TLR2, TNF, IFNG, IL4, IL10, SLC11A1
10hepatitis b30.0TLR2, IFNG, IL2RA, IL10, IL12B
11tetanus30.0TLR2, IFNG, IL4, IL2, IL2RA, IL10
12myasthenia gravis29.9IFNG, IL4, IL2, IL10, LTA
13uveitis29.8TNF, IFNG, IL4, IL2RA, IL10, LTA
14connective tissue disease29.7TNF, IL4, IL2, IL2RA, IL10
15atopy29.6TLR2, IFNG, IL12RB2, IL4, IL10, IL12B
16melanoma29.4TNF, IFNG, IL4, IL2, IL10, CD2
17tuberculosis29.3TLR2, TLR1, TNF, IFNGR1, IFNG, IL4
18sepsis29.3DEFB1, TLR2, TLR1, TNF, IL10, IL12B
19malaria29.3CD2, IL12B, IL10, IFNG, IFNGR1, TNF
20pulmonary tuberculosis29.2IL2RA, IL10, IL12B, SLC11A1, IL2, IL4
21sarcoidosis29.1DEFB1, TNF, IFNGR1, IFNG, IL12RB2, IL2
22colitis29.0DEFB1, TLR2, TNF, IFNG, IL12RB2, IL4
23psoriasis29.0TLR2, TNF, IFNG, IL4, IL2, IL2RA
24ulcerative colitis28.7LTA, SLC11A1, IL12B, DEFB1, TLR2, TNF
25rheumatoid arthritis28.7TLR2, TNF, PARK2, IFNG, IL4, IL2
26systemic lupus erythematosus28.6IL4, IL2, IL2RA, IL10, IL12B, CD2
27leukemia28.1TLR2, TNF, PARK2, IFNG, IL4, IL2
28borderline leprosy10.8
29indeterminate leprosy10.7
30hansen's disease10.7
31periodontitis10.5TLR2
32farmer's lung10.5IL2RA
33tularemia10.5TLR2
34lagophthalmos10.5
35intraocular lymphoma10.5IL10
36neuropathy10.4
37foot drop10.4
38tonsillitis10.4LTA
39blau syndrome10.4TNF
40autosomal dominant hyper ige syndrome10.4IFNG, IL4
41omenn syndrome10.4IL4
42hepatitis10.4
43skin disease10.3IL2, IL2RA
44pleural tuberculosis10.3IFNG, IL2RA
45neuritis10.3
46alcoholic hepatitis10.3TNF, IL10
47selective iga deficiency disease10.3LTA, IL10, IL4
48mycobacterium avium complex disease10.3IFNGR1
49bruton-type agammaglobulinemia10.3LTA, IL2, IL4
50molluscum contagiosum10.3

Graphical network of the top 20 diseases related to Leprosy:



Diseases related to leprosy

Symptoms for Leprosy

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Symptoms by clinical synopsis from OMIM:

246300

Clinical features from OMIM:

609888,246300,613407,607572,610988,613223

HPO human phenotypes related to Leprosy:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 autosomal recessive inheritance HP:0000007
3 abnormality of the immune system HP:0002715

Drugs & Therapeutics for Leprosy

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Drug clinical trials:

Search ClinicalTrials for Leprosy

Search NIH Clinical Center for Leprosy

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Leprosy

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Anatomical Context for Leprosy

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MalaCards organs/tissues related to Leprosy:

32
Skin, Eye, T cells, Testes, Bone, Monocytes, Bone marrow, Lymph node, Whole blood, Liver, Myeloid, Endothelial, Spleen, Retina, Heart, Colon, Kidney, Nk cells, Olfactory bulb, Tongue, Appendix, Pituitary, Neutrophil

FMA organs/tissues related to Leprosy:

14
Superficial peripheral nerves, Skin, Mucous membranes of the upper respiratory tract, Anterior chamber of the eyes, Testes

Animal Models for Leprosy or affiliated genes

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MGI Mouse Phenotypes related to Leprosy:

36 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.7TNF, PARK2, IFNG, IL4, IL2, IL10
2MP:00053678.3DEFB1, TLR2, IFNGR1, IFNG, IL12RB2, IL4
3MP:00053828.2TNF, IFNG, IL4, IL10, IL12B, KRT10
4MP:00053888.1TLR2, TNF, PARK2, IFNG, IL4, IL2
5MP:00036317.8TNF, PARK2, IFNGR1, IFNG, IL4, IL10
6MP:00053857.8TLR2, TNF, PARK2, IFNGR1, IFNG, IL12RB2
7MP:00053707.8TLR2, TNF, IFNGR1, IFNG, IL12RB2, IL4
8MP:00053797.8TLR2, TNF, IFNGR1, IFNG, IL12RB2, IL4
9MP:00053867.7TLR2, TNF, PARK2, IFNGR1, IFNG, IL2
10MP:00107717.6TLR2, TNF, PARK2, IFNGR1, IFNG, IL4
11MP:00053907.6TLR2, TNF, PARK2, IFNGR1, IFNG, IL4
12MP:00053787.5TLR2, TNF, PARK2, IFNG, IL4, IL2
13MP:00053847.4TLR2, TNF, PARK2, IFNGR1, IFNG, IL4
14MP:00053767.0TLR2, TNF, PARK2, IFNGR1, IFNG, IL12RB2
15MP:00020066.9IFNG, IFNGR1, TNF, TLR2, IL12RB2, IL2
16MP:00053816.9TLR2, TNF, IFNGR1, IFNG, IL12RB2, IL4
17MP:00053976.2IL12RB2, IFNG, IFNGR1, TNF, TLR1, TLR2
18MP:00107685.6IFNG, IFNGR1, PARK2, TNF, TLR2, DEFB1
19MP:00053875.2LTA, DEFB1, TLR2, TLR1, TNF, IFNGR1

Publications for Leprosy

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Articles related to Leprosy:

(show top 50)    (show all 1661)
idTitleAuthorsYear
1
Oral manifestation of lepromatous leprosy: diagnosis and management. (24848267)
2014
2
Borderline lepromatous leprosy with type 1 (downgrading) reaction. (24252148)
2013
3
Interleukin-17F single-nucleotide polymorphism (7488T>C) and its association with susceptibility to leprosy. (24164796)
2013
4
Role of HLA, KIR, MICA, and cytokines genes in leprosy. (23936864)
2013
5
History of infectious diseases development in the Old and the Middle Ages with the emphasis on the plague and leprosy. (23984623)
2013
6
Intolerance to leprosy multi-drug therapy: more common in women? (24428115)
2013
7
Genetic evidence of TAP1 gene variant as a susceptibility factor in Indian leprosy patients. (23395648)
2013
8
Bacterial load in the nose and its correlation to the immune response in leprosy patients. (23741885)
2013
9
The effect of systemic corticosteroid therapy on the expression of toll-like receptor 2 and toll-like receptor 4 in the cutaneous lesions of leprosy Type 1 reactions. (22348338)
2012
10
Identification of serological biomarkers of infection, disease progression and treatment efficacy for leprosy. (23283458)
2012
11
Comparing the clinical and histological diagnosis of leprosy and leprosy reactions in the INFIR cohort of Indian patients with multibacillary leprosy. (22745841)
2012
12
Leprosy among migrant workers: ensuring proper treatment. (23614250)
2012
13
Histopathological examination of nerve samples from pure neural leprosy patients: obtaining maximum information to improve diagnostic efficiency. (22415265)
2012
14
Hansen's disease (Leprosy): current and future pharmacotherapy and treatment of disease-related immunologic reactions. (22392826)
2012
15
Characterization of the profession/occupation of individuals affected by leprosy and the relationship with limitations in professional activities. (23077777)
2012
16
Is there a relation between hemicrania continua and leprosy? (23720896)
2012
17
Chronic rhinitis: a manifestation of leprosy. (21938685)
2011
18
Cytokine and protein markers of leprosy reactions in skin and nerves: baseline results for the North Indian INFIR cohort. (22180790)
2011
19
Leprosy elimination campaign in Qazvin province, Islamic Republic of Iran (2006-07). (22355944)
2011
20
Study of cytokine response against panel of purified Mycobacterium leprae antigens by using whole blood assay in subjects residing in a resettlement village of cured leprosy patients. (21229844)
2010
21
SNP 668C (-44) alters a NF-kappaB1 putative binding site in non-coding strand of human beta-defensin 1 (DEFB1) and is associated with lepromatous leprosy. (19460328)
2009
22
Functional haplotypes that produce normal ficolin-2 levels protect against clinical leprosy. (19434912)
2009
23
A case of recurrent rash and leg numbness mimicking systemic rheumatic disease: the occurrence of leprosy in a nonendemic area. (17551381)
2007
24
Leprosy masquerading as Melkersson-Rosenthal syndrome. (16353526)
2005
25
Tuberculoid leprosy confined to glans penis in two cases. (15282972)
2004
26
Linkage of leprosy susceptibility to Parkinson's disease genes. (15301585)
2004
27
Lepromatous leprosy with extensive unusual ulcerations and cachexia. Is it the first case of Lucio's phenomenon from Iran? (15217312)
2004
28
Molluscum contagiosum-like lesions in lepromatous leprosy. (15267197)
2003
29
Localized linear lesions in lepromatous leprosy. (11898466)
2001
30
Association and linkage of leprosy phenotypes with HLA class II and tumour necrosis factor genes. (11477474)
2001
31
Cutaneous cryptococcosis associated with lepromatous leprosy. (11589749)
2001
32
Lagophthalmos in leprosy. (9598404)
1998
33
The current situation of lagophthalmos and keratopathy of leprosy in PR China. (9598407)
1998
34
Charles Bonnet syndrome in leprosy; prevalence and clinical characteristics. (8712028)
1996
35
Host parasite response in nerve in leprosy. (8727123)
1996
36
Localized borderline lepromatous leprosy. (8537706)
1995
37
Reply: 'Results of surgical procedures for the correction of foot-drop and lagophthalmus due to leprosy'. (7861931)
1994
38
Comment: 'Results of surgical procedures for the correction of foot-drop and of lagophthalmus due to leprosy'. (8231612)
1993
39
Tongue involvement in lepromatous leprosy. (8425797)
1993
40
Electrocardiographic alterations in lepromatous leprosy patients with concomitant Trypanosoma cruzi infection. (8228450)
1993
41
Lepromatous leprosy: nasal manifestations and treatment with minocycline. (1543336)
1992
42
Camptodactyly simulating claw hand in a patient with indeterminate leprosy. (1783793)
1991
43
In vitro effect of interleukin-2 on proliferative responses of peripheral blood T cells from leprosy patients. (1781183)
1991
44
Single lesion subpolar lepromatous leprosy and its possible mode of origin. (2659697)
1989
45
Evaluation of anti-cardiolipin antibody and its cross-reactivity in sera of patients with lepromatous leprosy. (3740940)
1986
46
Should indeterminate leprosy ever be diagnosed? (7195888)
1981
47
Mechanism of nerve destruction in tuberculoid-borderline leprosy. An electron-microscopic study. (4582968)
1973
48
The Kveim test in lepromatous and tuberculoid leprosy. (5394258)
1969
49
Pure neural tuberculoid leprosy. (4283894)
1965
50
ELECTRON MICROSCOPIC STUDY OF BORDERLINE LEPROSY. (14166266)
1963

Variations for Leprosy

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Clinvar genetic disease variations for Leprosy:

6
id Gene Name Type Significance SNP ID Assembly Location
1TLR2NM_003264.3(TLR2): c.2029C> T (p.Arg677Trp)single nucleotide variantrisk factorrs121917864GRCh37Chr 4, 154626088: 154626088

Expression for genes affiliated with Leprosy

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Expression patterns in normal tissues for genes affiliated with Leprosy

Search GEO for disease gene expression data for Leprosy.

Pathways for genes affiliated with Leprosy

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Pathways related to Leprosy according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7LTA, IL10, IL4
2
Show member pathways
9.6TLR1, TLR2, DEFB1
39.5IL2, IFNG, TNF
4
Show member pathways
9.5LTA, TNF, TLR1, TLR2
5
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.4TLR2, TLR1, TNF, IL18RAP
69.4IL12B, TNF, TLR2
7
Show member pathways
9.4TLR2, TLR1, IL2, IL2RA
89.4IL10, IFNG, TNF, TLR2
9
Show member pathways
IL2 signaling events mediated by STAT537
9.3IL4, IL2, IL2RA, LTA
109.3IL18RAP, IL2RA, IL2, IFNG
119.2IFNG, IL4, IL2, IL2RA
129.2IL4, IL2, IL2RA, IL10
139.2TNF, IFNG, IL4, IL2
14
Show member pathways
Ras signaling in the CD4+ TCR pathway37
9.2IL2RA, IL2, IFNG, TNF
15
Show member pathways
9.2TLR2, TLR1, TNF, IL2, LTA
169.1IFNG, IL12RB2, IL2RA, IL12B
179.1IL12B, IFNG, TNF, TLR2
189.1IFNG, IL4, IL2, IL10, LTA
19
Show member pathways
Immune response IL 22 signaling pathway60
G protein signaling N RAS regulation pathway60
9.1IL12RB2, IL2, IL2RA, IL12B
209.0TNF, IL4, IL2RA, CD2
219.0TNF, IFNG, IL10, IL12B
22
Show member pathways
9.0TLR2, TLR1, IFNG, IL4, IL12B
23
Show member pathways
9.0TLR2, TLR1, TNF, IL12B, LTA
24
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway60
8.9TNF, IL4, IL2, IL2RA, LTA
25
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
8.9IL10, IL2, IL4, IFNG, TNF
26
Show member pathways
8.9TNF, IFNG, IL2, IL2RA, IL10
27
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
8.9TNF, IFNG, IL4, IL2, IL2RA
288.8IL12B, IL10, IFNG, TNF, TLR2
29
Show member pathways
8.8LTA, IFNG, IFNGR1, TNF
30
Show member pathways
8.8TNF, IFNGR1, IFNG, LTA
318.6TLR2, TLR1, TNF, IFNGR1, IFNG
32
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
8.5TNF, IFNG, IL2, IL10, IL12B, IL18RAP
338.4TNF, IFNG, IL4, IL2, IL10, IL12B
34
Show member pathways
Immune response CD16 signaling in NK cells60
8.4TNF, IFNGR1, IFNG, IL4, IL2
35
Show member pathways
Immune response IL 12 induced IFN gamma production60
8.3IFNG, IL12RB2, IL4, IL2, IL2RA, IL12B
368.2TNF, IFNG, IL4, IL2, IL10, IL12B
37
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
8.1TLR2, TLR1, TNF, IFNGR1, IFNG, IL4
387.8TLR2, TLR1, TNF, IFNGR1, IFNG, IL10
39
Show member pathways
7.6TLR2, TLR1, TNF, IFNGR1, IFNG, IL4
40
Show member pathways
7.5TNF, IL12RB2, IL4, IL2, IL2RA, IL10
41
Show member pathways
7.5TNF, IL12RB2, IL4, IL2, IL2RA, IL10
42
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
7.5TLR2, TLR1, TNF, IFNGR1, IFNG, IL2
43
Show member pathways
Type III interferon signaling37
7.4IFNGR1, IFNG, IL12RB2, IL4, IL2, IL2RA
44
Show member pathways
7.1TLR2, TNF, IFNGR1, IFNG, IL4, IL2
45
Show member pathways
7.1IL12RB2, TNF, TLR1, TLR2, IL4, IL2
46
Show member pathways
6.9IL10, IL12B, IL18RAP, IL2, IL4, IL12RB2
47
Show member pathways
6.8TNF, IFNGR1, IFNG, IL12RB2, IL4, IL2
48
Show member pathways
IL27-mediated signaling events37
6.8LTA, TLR2, TLR1, TNF, IFNGR1, IFNG
49
Show member pathways
6.4IL12RB2, IFNG, IFNGR1, TNF, IL4, IL2
50
Show member pathways
6.2IFNGR1, IFNG, IL12RB2, IL4, IL2, IL2RA

Compounds for genes affiliated with Leprosy

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Compounds related to Leprosy according to GeneCards/GeneDecks:

(show top 50)    (show all 135)
idCompoundScoreTop Affiliating Genes
1alpha-galactosylceramide449.7IL10, IFNG, IL4, IL2
2toxin-1449.6LTA, IL10, IL2, TNF
3glatiramer acetate44 1110.6IL10, IFNG, IL2, IL4
4betaseron449.5IFNG, IL10, IL4
5natalizumab44 1110.5IL2RA, IFNG, IL10, TNF
6gold sodium thiomalate449.5IFNG, IL2RA, IL2, TNF
7ifn-alpha449.4PARK2, IL2, IL10, IL2RA, IFNG
8interferon gamma449.4TNF, IL2, IL4, IFNG, IL10
9etanercept44 50 1111.3TNF, IFNG, LTA, IL10
10gm-csf44 2810.3IL10, IL2, IL4, IFNG, TNF
112,5-oligoadenylate449.3TNF, IL2, IL2RA, IL10, IFNG
125 aminosalicylic acid449.2IL10, TNF, IL2RA, IL12B
13peptidoglycan44 2810.2IL10, TLR1, TNF, TLR2, IL12B
14poly(i-c)449.2TLR2, IL4, IFNG, IL12B, TNF
15thalidomide44 50 61 1112.1IL10, IL2RA, IL2, IFNG, TNF
16infliximab44 50 1111.1IFNG, LTA, TNF, IL4, IL2RA, IL10
17ivig449.1IFNG, TNF, IL4, IL2RA, IL10, LTA
18chloroquine44 2 50 28 1113.1TNF, IL10, IL2RA, IL2, IL4
19mycophenolate mofetil44 50 1111.1LTA, TNF, IL2RA, IFNG, IL10, IL2
20lipoteichoic acid449.1TNF, IL10, IL12B, TLR1, TLR2, LTA
21prednisolone44 28 1111.1TNF, IFNG, IL2, IL2RA, IL10, LTA
22imiquimod44 61 28 1112.0IL10, IFNG, TNF, TLR1, TLR2, IL12B
23polymyxin b449.0IL10, IL4, IFNG, TNF, TLR2, DEFB1
24herbimycin a44 6110.0LTA, IL2RA, TNF, IL4, IFNG, IL2
25con a449.0IFNG, IL4, CD2, IL10, IL2RA, IL2
26endotoxin449.0LTA, TNF, IFNG, TLR2, IL12B, IL10
27rolipram44 61 2811.0IL4, IL10, TNF, IFNG
28hydrocortisone44 2 61 1111.9IL4, IL10, IFNG, TNF, IL2
29il-12448.8IL2, IL4, IL10, IFNG, IL12B, TNF
30okt3448.8IL10, IL2RA, LTA, TNF, IFNG, IL4
31neopterin448.8TNF, IL4, IL2, IL2RA, IL10, IFNG
32tacrolimus44 50 1110.8IFNG, IL10, IL2RA, IL2, IL4, TLR2
33indomethacin44 28 61 1111.8IL4, TNF, IL2, LTA, IL2RA, IFNG
34histamine44 28 2410.7IL2, IL4, IL2RA, IL10, IFNG, TNF
35polyinosinic-polycytidylic acid448.7IL12B, IL10, IL4, IFNG, TNF, TLR2
36sb 20358044 619.6TNF, IFNG, IL4, IL10, IL12B, TLR2
37vitamin d448.5LTA, IL12B, SLC11A1, KRT10, TLR2, IL2RA
38nitric oxide44 24 1110.4TLR2, TNF, LTA, IL10, SLC11A1, PARK2
39thymidine44 249.4CD2, IL10, IL2RA, IL4, IFNG, IL2
40vegf448.4LTA, IFNG, PARK2, TNF, TLR2, IL2RA
41cycloheximide448.4IL10, TLR2, IL2, TNF, IL4, IL12B
42pentoxifylline44 119.3IL2RA, IL10, IL2, IL12B, IL4, IFNG
43ionomycin448.2LTA, IL10, IL2RA, IL4, IFNG, CD2
44rantes448.2DEFB1, IL4, IL2, IL2RA, IL10, IL12B
45cyclosporin a44 28 6110.2LTA, TLR2, TNF, IFNG, IL4, IL2
46il 10448.1TLR2, TNF, IFNG, IL4, IL2, IL2RA
47pge2448.1TNF, IFNG, IL4, IL2, IL2RA, IL10
48calcitriol44 61 24 1111.0IL2RA, TLR2, KRT10, LTA, IL10, IL2
49dexamethasone44 50 28 1110.5IL2RA, DEFB1, TLR2, TNF, IFNG, IL4
50tyrosine447.0IL4, IFNGR1, TLR2, LTA, CD2, IL12RB2

GO Terms for genes affiliated with Leprosy

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Cellular components related to Leprosy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Toll-like receptor 1-Toll-like receptor 2 protein complexGO:03535410.0TLR1, TLR2
2external side of plasma membraneGO:0098978.4CD2, TLR2, TNF, IFNG, IL12RB2, IL4
3integral component of plasma membraneGO:0058877.7TLR2, TLR1, TNF, IFNGR1, IL12RB2, CD2
4extracellular spaceGO:0056157.5TNF, IFNG, IL4, IL2, IL10, IL12B

Biological processes related to Leprosy according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idNameGO IDScoreTop Affiliating Genes
1cellular response to triacyl bacterial lipopeptideGO:07172710.4TLR2, TLR1
2detection of triacyl bacterial lipopeptideGO:04249510.4TLR2, TLR1
3positive regulation of chronic inflammatory response to antigenic stimulusGO:00287610.3TNF, LTA
4regulation of isotype switchingGO:04519110.2IL4, IL10
5positive regulation of interleukin-18 productionGO:03274110.2TLR2, TNF
6positive regulation of vitamin D biosynthetic processGO:06055710.2TNF, IFNG
7positive regulation of calcidiol 1-monooxygenase activityGO:06055910.2TNF, IFNG
8regulation of T cell homeostatic proliferationGO:04601310.2IL2, IL2RA
9type 2 immune responseGO:04209210.2IL10, IL4
10positive regulation of interleukin-6 biosynthetic processGO:04541010.1TLR1, IFNG
11receptor biosynthetic processGO:03280010.1TNF, IL10
12positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.1TNF, LTA
13macrophage activationGO:04211610.1TLR1, SLC11A1
14negative regulation of cytokine secretion involved in immune responseGO:00274010.1IL10, TNF
15defense response to Gram-positive bacteriumGO:05083010.1TLR2, TNF, LTA
16positive regulation of MHC class II biosynthetic processGO:04534810.1IL10, IL4, IFNG
17positive regulation of isotype switching to IgG isotypesGO:04830410.0IL2, IL4, IFNG
18positive regulation of nitric oxide biosynthetic processGO:04542910.0IFNG, TNF, TLR2
19positive regulation of cytokine secretionGO:05071510.0TLR2, TNF, IL10
20protein import into nucleus, translocationGO:00006010.0SLC11A1, IFNG, TNF
21positive regulation of chemokine biosynthetic processGO:04508010.0TNF, IFNG, IL4
22positive regulation of tumor necrosis factor biosynthetic processGO:0425359.9TLR1, TLR2
23negative regulation of interleukin-17 productionGO:0327009.9TLR2, IFNG, IL12B
24humoral immune responseGO:0069599.9TNF, IFNG, LTA
25positive regulation of interleukin-12 productionGO:0327359.9IL12B, IFNG, TLR2
26positive regulation of interleukin-10 productionGO:0327339.9TLR2, IL4, IL12B
27positive regulation of tissue remodelingGO:0341059.9IL2, IL12B
28positive regulation of smooth muscle cell apoptotic processGO:0343939.8IFNG, IL12B
29positive regulation of NF-kappaB import into nucleusGO:0423469.8IL12B, TNF, TLR2
30positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.8IL4, IL2, IL12B
31positive regulation of T-helper 1 type immune responseGO:0028279.7SLC11A1, IL12B
32positive regulation of inflammatory responseGO:0507299.7TLR2, IL2, IL12B
33positive regulation of osteoclast differentiationGO:0456729.7IL12B, IFNG, TNF
34positive regulation of T cell proliferationGO:0421029.7IL12B, IL4, IFNG
35defense response to bacteriumGO:0427429.6DEFB1, IFNG, IL10, SLC11A1
36natural killer cell activationGO:0301019.6CD2, IL12B, IL2
37positive regulation of interleukin-17 productionGO:0327409.6IL12B, IL2
38defense response to protozoanGO:0428329.6IFNG, IL4, IL12B, SLC11A1
39positive regulation of tumor necrosis factor productionGO:0327609.5TLR2, IFNG, IL12B, CD2
40cellular response to lipopolysaccharideGO:0712229.5IL12B, IL10, IFNG
41response to drugGO:0424939.4TNF, IFNG, IL4, IL10, LTA
42positive regulation of activated T cell proliferationGO:0421049.4IL12B, IL2RA, IL2, IL4
43cell surface receptor signaling pathwayGO:0071669.4IFNG, IL12RB2, IL2RA, IL18RAP, CD2
44inflammatory responseGO:0069549.4TLR2, TLR1, TNF, IL10, IL18RAP, SLC11A1
45positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.2TNF, IL4, IL10
46negative regulation of growth of symbiont in hostGO:0441309.1LTA, IL12B, IL10, IFNG, TNF, TLR2
47apoptotic processGO:0069159.1TLR2, TNF, IFNG, IL2RA, CD2, LTA
48positive regulation of interferon-gamma productionGO:0327299.1TNF, IL12RB2, IL2, IL12B, SLC11A1, LTA
49positive regulation of transcription from RNA polymerase II promoterGO:0459448.9TLR2, TNF, IFNG, IL4, IL2, IL10
50immune responseGO:0069558.8DEFB1, TLR2, TLR1, IL4, IL2, IL2RA

Molecular functions related to Leprosy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine receptor activityGO:0048969.7IL12B, IL12RB2
2receptor activityGO:0048729.1CD2, IL18RAP, TLR1, TLR2
3growth factor activityGO:0080839.0IL4, IL2, IL10, IL12B
4cytokine activityGO:0051258.2LTA, IL12B, IL10, IL2, IL4, IFNG

Products for genes affiliated with Leprosy

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  • Antibodies
  • Proteins
  • Lysates

Sources for Leprosy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet