MCID: LPR017
MIFTS: 20

Leprosy 5 malady

Categories: Genetic diseases, Infectious diseases, Neuronal diseases, Reproductive diseases, Rare diseases

Aliases & Classifications for Leprosy 5

Aliases & Descriptions for Leprosy 5:

Name: Leprosy 5 54 29
Leprosy, Protection Against 54 13

Classifications:



External Ids:

OMIM 54 613223

Summaries for Leprosy 5

MalaCards based summary : Leprosy 5, also known as leprosy, protection against, is related to leprosy and lepromatous leprosy. An important gene associated with Leprosy 5 is TLR1 (Toll Like Receptor 1). The drugs Dapsone and Isoniazid have been mentioned in the context of this disorder.

Description from OMIM: 613223

Related Diseases for Leprosy 5

Diseases in the Leprosy family:

Leprosy 5 Leprosy 4

Diseases related to Leprosy 5 via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 leprosy 9.8
2 lepromatous leprosy 9.6
3 peritonitis 9.6

Symptoms & Phenotypes for Leprosy 5

Clinical features from OMIM:

613223

Drugs & Therapeutics for Leprosy 5

Drugs for Leprosy 5 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 75)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dapsone Approved, Investigational Phase 4 80-08-0 2955
2
Isoniazid Approved Phase 4,Phase 1 54-85-3 3767
3
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
4
leucovorin Approved, Nutraceutical Phase 4 58-05-9 54575, 6560146 143
5 Anti-Bacterial Agents Phase 4,Phase 3,Phase 1
6 Anti-Infective Agents Phase 4,Phase 3,Phase 1
7 Antimalarials Phase 4
8 Antiparasitic Agents Phase 4
9 Antiprotozoal Agents Phase 4
10 Folic Acid Antagonists Phase 4
11 Vitamin B Complex Phase 4
12 Antimetabolites Phase 4,Phase 1
13 Antitubercular Agents Phase 4,Phase 1
14 Hypolipidemic Agents Phase 4,Phase 1
15 Lipid Regulating Agents Phase 4,Phase 1
16 Folate Nutraceutical Phase 4
17 Vitamin B9 Nutraceutical Phase 4
18
Goserelin Approved Phase 3 65807-02-5 47725 5311128
19
Leuprolide Approved, Investigational Phase 3 53714-56-0 3911 657181
20
Benzoyl peroxide Approved Phase 3 94-36-0 7187
21
Clindamycin Approved, Vet_approved Phase 3 18323-44-9 29029
22 Androgens Phase 3
23 Angiogenesis Inhibitors Phase 3
24 Angiogenesis Modulating Agents Phase 3
25 Antineoplastic Agents, Hormonal Phase 3,Phase 2
26 Fertility Agents Phase 3
27 Hormones Phase 3,Phase 2
28 Immunosuppressive Agents Phase 3,Phase 2
29 Clindamycin palmitate Phase 3
30 Clindamycin phosphate Phase 3
31 Dermatologic Agents Phase 3
32
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
33
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
34 Antiemetics Phase 2
35 Anti-Inflammatory Agents Phase 2
36 Autonomic Agents Phase 2
37 Gastrointestinal Agents Phase 2
38 glucocorticoids Phase 2
39 Hormone Antagonists Phase 2
40 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
41 Methylprednisolone acetate Phase 2
42 Methylprednisolone Hemisuccinate Phase 2
43 Neuroprotective Agents Phase 2
44 Peripheral Nervous System Agents Phase 2
45 Prednisolone acetate Phase 2
46 Prednisolone hemisuccinate Phase 2
47 Prednisolone phosphate Phase 2
48 Protective Agents Phase 2
49
Estradiol Approved, Investigational, Vet_approved Phase 1 50-28-2 5757 53477783
50
Ethinyl Estradiol Approved Phase 1 57-63-6 5991

Interventional clinical trials:

(show all 14)
id Name Status NCT ID Phase
1 Effect of Weight and/or Obesity on Dapsone Drug Concentrations Completed NCT01165840 Phase 4
2 Feasibility and Effectiveness of Community Based Isoniazid Preventive Therapy in Kenya Completed NCT00850915 Phase 4
3 Clinical Utility Of Genetic Screening For HLA-B*1301, On Susceptibility To Dapsone Hypersensitivity Syndrome Recruiting NCT02550080 Phase 4
4 Thalidomide for the Treatment of Hormone-Dependent Prostate Cancer Completed NCT00004635 Phase 3
5 To Compare the Efficacy and Safety of Clindamycin Phosphate 1.2% / Benzoyl Peroxide 5% Gel of CHL Versus DUAC® Gel Completed NCT02005666 Phase 3
6 Leprosy Skin Test Antigens Trial Completed NCT00128193 Phase 2
7 Progression of HIV-Disease Under Low Dose Corticosteroids Completed NCT01299948 Phase 2
8 Leprosy Skin Test Antigens Phase 1 Completed NCT01920750 Phase 1
9 Study of the Safety and Immunogenicity of Bacille Calmette Guerin (BCG) Vaccine Completed NCT00654316 Phase 1
10 Measurement of Anti-TB Drugs in Lung Tissue From Patients Having Surgery to Treat Tuberculosis Completed NCT00816426 Phase 1
11 Self-verification and Support Via Mobile Phones Drastically Improves Tuberculosis Treatment Success in LMIC Settings Completed NCT03135366
12 Platelet Rich Plasma and Perineural Injection Therapy for Carpal Tunnel Syndrome Recruiting NCT02696161
13 Low Level Laser Therapy Effects in Peripheral Nerves Patient With Leprosy. Recruiting NCT03072004
14 Extramembranous and Interosseous Technique of Tibialis Posterior Tendon Transfer Recruiting NCT01751503

Search NIH Clinical Center for Leprosy 5

Genetic Tests for Leprosy 5

Genetic tests related to Leprosy 5:

id Genetic test Affiliating Genes
1 Leprosy 5 29

Anatomical Context for Leprosy 5

Publications for Leprosy 5

Articles related to Leprosy 5:

id Title Authors Year
1
Relapse in a borderline-tuberculoid case of leprosy 5 years after the release from rifampicin monotherapy. ( 9217356 )
1997
2
Phagocytosis in leprosy. 5. The effect of the infection with Mycobacterium lepraemurium on the level of diverse hydrolytic lysosomal enzymes of murine peritoneal macrophages. ( 6890533 )
1982
3
Chemotherapeutic trials in leprosy. 5. A study of methods used in clinical trials in lepromatous leprosy. ( 4917107 )
1967

Variations for Leprosy 5

ClinVar genetic disease variations for Leprosy 5:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 TLR1 NM_003263.3(TLR1): c.743A> G (p.Asn248Ser) single nucleotide variant risk factor rs4833095 GRCh37 Chromosome 4, 38799710: 38799710

Expression for Leprosy 5

Search GEO for disease gene expression data for Leprosy 5.

Pathways for Leprosy 5

GO Terms for Leprosy 5

Sources for Leprosy 5

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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