MCID: LPT005
MIFTS: 36

Leptin Deficiency malady

Genetic diseases (common), Metabolic diseases categories

Aliases & Classifications for Leptin Deficiency

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Aliases & Descriptions for Leptin Deficiency:

Name: Leptin Deficiency 22
 
Obesity, Severe, Due to Leptin Deficiency 22 24


Classifications:



Summaries for Leptin Deficiency

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MalaCards based summary: Leptin Deficiency, also known as obesity, severe, due to leptin deficiency, is related to obesity and congenital leptin deficiency. An important gene associated with Leptin Deficiency is LEP (Leptin), and among its related pathways are Development_Leptin signaling via JAK/STAT and MAPK cascades and Cardiomyocyte Differentiation through BMP Receptors. Affiliated tissues include bone, t cells and liver, and related mouse phenotypes are renal/urinary system and adipose tissue.

Related Diseases for Leptin Deficiency

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Diseases related to Leptin Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 70)
idRelated DiseaseScoreTop Affiliating Genes
1obesity30.5GH1, GHR, IGF1, LEP, LEPQTL1, LEPR
2congenital leptin deficiency10.7
3obesity, morbid, due to leptin deficiency10.5
4classic kaposi sarcoma10.3LEP, LEPQTL1
5lipodermatosclerosis10.3LEP, LEPR
6hepatitis10.2
7hypogonadism10.2
8best vitelliform macular dystrophy10.2LEP, LEPQTL1
9adrenomyeloneuropathy10.2IGF1, LEP
10conversion disorder10.2NPPA, NPPB
11conus medullaris neoplasm10.2GH1, IGF1
12syphilitic spinal sclerosis10.2NPPA, NPPB
13hypothryoidism, congenital, nongoitrous 410.2GH1, IGF1
14diabetic autonomic neuropathy10.2NPPA, NPPB
15syndrome with corpus callosum agenesis /dysgenesis as a major feature10.2NPPA, NPPB
16morbid obesity10.2
17idiopathic hypersomnolence10.2NPPA, NPPB
18pituitary dermoid and epidermoid cysts10.1GH1, GHR
19muscle hypertrophy10.1IGF1, LEP
20gemistocytic astrocytoma10.1NPPA, NPPB
21ulcer of lower limbs10.1GH1, IGF1
22intestinal volvulus10.1NPPA, NPPB
23fundus dystrophy10.1GH1, GHR
24pseudohermaphroditism10.1IGF1, LEP
25pericarditis10.1NPPA, NPPB
26fetal methimazole syndrome10.1IGF1, LEP, LEPQTL1
27primary cerebellar degeneration10.1LEP, NPPA, NPPB
28endodermal sinus tumor10.1IGF1, LEP
29cetp-related hyperalphalipoproteinemia10.1GH1, IGF1, LEP
30postherpetic neuralgia10.1GH1, IGF1
31fallopian tube leiomyoma10.1IGF1, LEP, LEPR
32hypertrichosis10.1GH1, IGF1, LEP
33angelman syndrome10.1GH1, IGF1, LEP
34acquired polycythemia10.1IGF1, LEP, LEPR
35angular blepharoconjunctivitis10.1IGF1, LEP
36ureter cancer10.0GH1, GHR, LEP
37brain ischemia10.0GH1, IGF1, NPPB
38ichthyosis lamellar 110.0NPPA, NPPB
39alzheimer disease type 110.0GH1, GHR
40atherosclerosis10.0
41liver disease10.0
42acute pancreatitis10.0
43central sleep apnea10.0
44lateral sclerosis10.0
45glucose intolerance10.0
46fatty liver disease10.0
47hypogonadotropism10.0
48lipodystrophy10.0
49myocarditis10.0
50pancreatitis10.0

Graphical network of the top 20 diseases related to Leptin Deficiency:



Diseases related to leptin deficiency

Symptoms for Leptin Deficiency

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Drugs & Therapeutics for Leptin Deficiency

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Drugs for Leptin Deficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
LopinavirapprovedPhase 4, Phase 3338192725-17-092727
Synonyms:
(1S-(1R*(R*),3R*,4R*))-N-(4-(((2,6-Dimethylphenoxy)acetyl)amino)-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl)tetrahydro-alpha-(1-methylethyl)-2-oxo-1(2H)-pyrimidineacetamide
(2S)-N-[(2S,4S,5S)-5-[[2-(2,6-dimethylphenoxy)acetyl]amino]-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide
(alphaS)-Tetrahydro-N-((alphaS)-alpha-((2S,3S)-2-hydroxy-4-phenyl-3-(2-(2,6-xylyloxy)acetamido)butyl)phenethyl)-alpha-isopropyl-2-oxo-1(2H)-pyrimidineacetamide
1(2H)-Pyrimidineacetamide, N-[(1S,3S,4S)-4-[[(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-alpha-(1-methylethyl)-2-oxo-, (alphaS)- (9CI)
192725-17-0
1mui
2o4s
2q5k
2rkf
2rkg
A 157378
A 157378.0
A-157378-0
A-157378.0
AB1
ABT 157378
ABT 378
ABT-378
ABT-378, LOPINAVIR
AC1L3OPJ
AIDS032937
Aluviran
C12871
C37H48N4O5
 
CHEBI:40456
CHEMBL729
CID92727
D01425
DB01601
Kaletra
Koletra
LPV
LS-173766
Lopinavir
Lopinavir (JAN/USAN/INN)
Lopinavir [USAN:INN:BAN]
MolPort-003-848-410
N-(4-(((2,6-dimethylphenoxy)acetyl)amino)-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl)tetrahydro-alpha-(1-methylethyl)-2-oxo-1(2H)-pydrimidineacetamide
N-{1-BENZYL-4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-5-PHENYL-PENTYL}-3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRAMIDE
NCGC00164576-01
NCGC00164576-02
RS-346
S1380_Selleck
SID124893167
SID144205757
SID50111692
UNII-2494G1JF75
a-157378-0
a-157378.0
2
Ritonavirapproved, investigationalPhase 4, Phase 3833155213-67-5392622
Synonyms:
1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[[(2S)-3-methyl-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]butanoyl]amino]-1,6-diphenylhexan-2-yl]carbamate
155213-67-5
1hxw
1sh9
5-Thiazolylmethyl ((alphaS)-alpha-((1S,3S)-1-hydroxy-3-((2S)-2-(3-((2-isopropyl-4-thiazolyl)methyl)-3-methylureido)-3-methylbutyramido)-4-phenylbutyl)phenethyl)carbamate
5-Thiazolylmethyl ((alphaS)-alpha-((1S,3S-1-hydroxy-3-((2S)-2-(3-((2-isopropyl-4-thiazolyl)methyl)-3-methylureido)-3-methylbutyramido)-4-phenylbutyl)phenethyl)carbamate
538, ABT
A-84538
ABBOTT-84538
ABT 538
ABT 84538
ABT-538
ABT538
AC-733
AC1L94GB
AKOS000280930
Abbott 84538
BIDD:GT0387
BIDD:PXR0023
Bio-0093
C07240
C37H48N6O5S2
CHEBI:45409
CHEMBL163
CID392622
CPD000466395
D00427
D019438
 
DB00503
DRG-0244
FT-0082824
HMS2051B08
HSDB 7160
LS-148860
MLS000759541
MLS001424063
MolPort-000-883-877
N-[(2S,4S,5S)-4-hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl]-N~2~-(methyl{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}carbamoyl)-L-valinamide
NCGC00159462-02
NSC693184
Norvir
Norvir (TM)
Norvir (TN)
Norvir Sec
RIT
RTV
Ritonavir
Ritonavir (JAN/USAN/INN)
Ritonavir [USAN]
Ritonavir is an inhibitor of HIV protease used to treat HIV infection and AIDS.
Ritonavirum
S1185_Selleck
SAM001246783
SMR000466395
STK634209
ZINC03944422
ritonavir
3
Exenatideapproved, investigationalPhase 4257141758-74-915991534
Synonyms:
141732-76-5
141758-74-9
286014-72-0
335149-21-8
AC 2993
AC 2993 LAR
AC 2993A
AC-2993
AC002993
AC2993
AC2993a
Bydureon
Byetta
 
C074031
CHEBI:490990
CHEMBL414357
Ex4 peptide
Exenatide
Exenatide Synthetic
Exenatide synthetic
Exendin 4
Exendin 4 (Heloderma suspectum)
Exendin-4
Extendin-4
LY2148568
Synthetic exendin-4
UNII-9P1872D4OL
4
Cholecalciferolapproved, nutraceuticalPhase 4, Phase 375567-97-06221, 10883523, 5280795
Synonyms:
()-Vitamin D3
(+)-Vitamin D3
(+)-vitamin D3
(1S,3Z)-3-[(2e)-2-[(1R,3AR,7as)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexan-1-ol
(3S,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol
(3beta,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol
(3beta,5Z,7e)-9,10-Secocholesta-5,7,10(19)-trien-3-ol
(3beta,Z,7E)-9,10-Secocholesta-5,7,10(19)-trien-3-ol
(5E,7E)-9,10-Secocholesta-5,7,10-trien-3-ol
(5Z,7E)-(3S)-9,10-seco-5,7,10(19)-cholestatrien-3-ol
(5Z,7E)-(3S)-9,10-secocholesta-5,7,10(19)-trien-3-ol
(5Z,7e)-(3S)-9,10-Secocholesta-5,7,10(19)-trien-3-ol
1406-16-2
25(OH)D
3-beta,Z,7E-9,10-Secocholestr-5,7,10(19)-trien-3-ol
47763_SUPELCO
57651-82-8
67-97-0
7-Dehydrocholesterol activated
7-Dehydrocholesterol, Activated
7-Dehydrocholesterol, irradiated
7-Dehydrocholestrol, activated
8024-19-9
8050-67-7
89193_FLUKA
9,10-Seco(5Z,7E)-5,7,10(19)-cholestatrien-3-ol
9,10-Seco(5Z,7E)-5,7,10(19)-cholestatrien-3beta-ol
9,10-Secocholesta-5(Z),7(E),10(19)-trien-3(.beta.)-ol
9,10-Secocholesta-5,7,10(19)-trien-3-beta-ol
9,10-Secocholesta-5,7,10(19)-trien-3-ol
9,10-Secocholesta-5,7,10-trien-3-ol
AB1002422
AC-11697
AC1L1ECK
AC1L1M23
AC1LU7IZ
AC1NQXLN
AC1NR2UO
AC1NR2UR
AC1NR2UU
AC1NS4AJ
AC1NSHJX
AC1O5EOF
AC1O7GAV
AC1O7GQ3
AC1O8FEU
AC1O8PWJ
AC1OF2GI
AC1OF2GL
AC1OIEW5
AC1OIEWB
ACon1_001997
Activated 7-dehydrocholesterol
Arachitol
BPBio1_000460
BSPBio_000418
BSPBio_002408
Bio-0845
C05443
C1357_SIAL
C27H44O
C9756_SIGMA
C9774_SIAL
CAS-67-97-0
CC
CCRIS 5813
CCRIS 6286
CHEBI:283119
CHEBI:28940
CHEMBL1042
CHEMBL432780
CID10000117
CID10045875
CID10340013
CID10883523
CID10894379
CID11014566
CID11025493
CID11058152
CID11463269
CID1548921
CID2735
CID5280795
CID5283710
CID5283711
CID5283712
CID5353527
CID5363362
CID6221
CID6432644
CID6604201
CID6604662
CID6708595
CID6713938
CID6992015
CID6992016
CID7067439
CID7067440
CID7251172
CID7251174
CID9821465
Calciol
Cholecalciferol
Cholecalciferol (D3)
Cholecalciferol (JP15/USP)
Cholecalciferol D3
Cholecalciferol [USAN:BAN:JAN]
Cholecalciferol, D3
Cholecalciferolum
 
Colecalciferol
Colecalciferol (INN)
Colecalciferolo
Colecalciferolo [DCIT]
Colecalciferolum
Colecalciferolum [INN-Latin]
Colecalcipherol
D00188
D3-Vicotrat
D3-Vigantol
DB00169
Delsterol
Delta-D
Delta-D (TN)
Deparal
Devaron
DivK1c_006276
Duphafral D3 1000
EINECS 200-673-2
EINECS 215-797-2
EPA Pesticide Chemical Code 202901
Ebivit
FeraCol
Granuvit D3
HMS1569E20
HMS2092M12
HSDB 820
I05-0041
Irradiated 7-dehydrocholesterol
KBio1_001220
KBio2_001643
KBio2_004211
KBio2_006779
KBio3_001628
KBioGR_001602
KBioSS_001643
LMST03020001
LMST03020219
LMST03020220
LMST03020221
LS-1570
LS-825
LT00244775
MEGxm0_000458
Micro-dee
MolPort-001-740-051
MolPort-001-785-972
MolPort-003-666-021
MolPort-004-946-964
NCGC00016301-01
NCGC00017328-01
NCGC00091072-01
NCGC00142511-01
NCGC00159331-02
NCGC00159331-04
NCGC00178668-01
NCGC00179565-01
NCGC00179565-02
NEO Dohyfral D3
NSC 375571
NSC-375571
NSC375571
Oleovitamin D3
Prestwick0_000429
Prestwick1_000429
Prestwick2_000429
Prestwick3_000429
Prestwick_63
Provitamine
Provitina
Quintox
Rampage
Ricketon
SMP1_000068
SPBio_001298
SPBio_002357
SR-05000001559
SR-05000001559-3
ST057172
SpecPlus_000180
Spectrum2_001369
Spectrum3_000764
Spectrum4_001201
Spectrum_001163
TNP00266
Trivitan
UNII-1C6V77QF41
UPCMLD-DP152
UPCMLD-DP152:001
VITAMIN D
VITAMIN D3 POWDER
VITAMIN_D3
Vi-De3
Vi-de-3-hydrosol
VidDe-3-hydrosol
Videkhol
Vigantol
Vigorsan
Vitamin D3
Vitamin D3 emulsifiable
Vitinc Dan-Dee-3
ZINC04474460
ZINC04492874
ZINC04492875
ZINC04492876
ZINC04492878
bmse000507
calciol
cholecalciferol
delta-D
vitamin d-3
5
Ergocalciferolapproved, nutraceuticalPhase 4, Phase 388550-14-65280793
Synonyms:
'Ergosterol irradiated'
(+)-Vitamin D2
(3-beta,5Z,7E,22E)-9,10-Secoergosta-5,7,10,(19),22-tetraen-3-ol
(3S,5Z,7E,14xi,17alpha,22E)-9,10-secoergosta-5,7,10,22-tetraen-3-ol
(3S,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol
(3S,5Z,7E,22E)-9,10-secoergosta-5,7,10,22-tetraen-3-ol
(3beta,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol
(3beta,5Z,7e,22e)-9,10-Secoergosta-5,7,10(19),22-tetraen-3-ol
(5E,7E,22E)-9,10-Secoergosta-5,7,10,22-tetraen-3-ol
(5Z,7E,22E)-(3S)-9,10-seco-5,7,10(19),22-ergostatetraen-3-ol
(5Z,7E,22E)-(3S)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol
(5Z,7e,22e)-(3S)-9,10-Seco-5,7,10(19),22-ergostatetraen-3-ol
(5Z,7e,22e)-(3S)-9,10-Secoergosta-5,7,10(19),22-tetraen-3-ol
22-Tetraen 3beta 9,10,Secoergosta-5,7,10(19)-ol
31316-19-5
4-Methylene-3-[2-[tetrahydro-7a-methyl-1-(1,4,5-trimethyl-2-hexenyl)-4(3aH)-indanylidene]ethylidene]-Cyclohexanol
47768_SUPELCO
50-14-6
7489-18-1
7E677DC1-E1C4-4FC5-8F4A-BCE1857F7E87
8017-28-5
9,10,Secoergosta-5,7,10(19),22-tetraen 3.beta.-ol
9,10-Seco(5Z,7E,22E)-5,7,10(19),22-ergostatetraen-3-ol
9,10-Secoergosta-5,7,10(19),22-tetraen-3-beta-ol
9,10-Secoergosta-5,7,10(19),22-tetraen-3b-ol
95220_FLUKA
95220_SIGMA
AC-1355
AC1L1FIE
AC1NQXLH
AC1NS4DE
AC1NS9GI
AC1NSSVD
AC1NWAM3
AC1O5EDK
AC1O6WAM
ACon1_002187
Activated ergosterol
BPBio1_000418
BSPBio_000380
BSPBio_001974
Buco-D
C05441
C28H44O
CALCIFEROL IN A GELATIN MATRIX
CALCIFEROL, U.S.P.
CHEBI:28934
CHEMBL1536
CID11003810
CID3249
CID5280793
CID5315257
CID5353610
CID5356615
CID5702050
CID6432478
CID6536972
Calciferol
Calciferol (TN)
Calciferol (vitamin D2)
Calciferolum
Calciferon 2
Condacaps
Condocaps
Condol
Crtron
Crystallina
D-Arthin
D-Tracetten
D00187
DB00153
Daral
Davitamon D
Davitin
De-rat concentrate
Decaps
Dee-Osterol
Dee-Ron
Dee-Ronal
Dee-Roual
Deltalin
Deratol
Detalup
Diactol
Divit urto
Doral
Drisdol
Drisdol (TN)
E5750_SIGMA
EINECS 200-014-9
Ercalciol
Ergocalciferol
Ergocalciferol (D2)
Ergocalciferol (JP15/USP)
Ergocalciferol [INN:BAN:JAN]
Ergocalciferol oil
Ergocalciferol: Vitamin D
 
Ergocalciferolo
Ergocalciferolo [DCIT]
Ergocalciferols
Ergocalciferolum
Ergocalciferolum [INN-Latin]
Ergorone
Ergosterol activated
Ergosterol irradiated
Ergosterol, irradiated
Ertron
Fortodyl
Geltabs
Geltabs Vitamin D
HMS1920K20
HMS2091B19
HMS502I07
HSDB 819
Haliver
Hi-Deratol
Hyperkil
I05-0022
IDI1_000805
Infron
Irradiated ergosta-5,7,22-trien-3-beta-ol
Irradiated ergosta-5,7,22-trien-3.beta.-ol
Irradiated ergosta-5,7,22-trien-3beta-ol
Irradiated ergosterol
LMST03010001
LMST03010014
LS-3228
MEGxm0_000466
MLS001332467
MLS001332468
Metadee
Mina D2
MolPort-001-740-057
MolPort-001-793-930
MolPort-002-526-645
MolPort-003-666-178
MolPort-006-822-629
Mulsiferol
Mykostin
NCGC00142497-01
NCGC00179579-01
NCGC00179579-02
NSC 62792
NSC62792
Novovitamin-D
Oleovitamin D
Oleovitamin D, Synthetic
Oleovitamin D2
Osteil
Ostelin
Prestwick3_000420
Prestwick_554
Radiostol
Radstein
Radsterin
Rodine C
Rodinec
SMR000857106
SPECTRUM1500276
ST057150
STOCK1N-53397
Shock-ferol
Shock-ferol sterogyl
Sorex C.R
Sorex C.R.
Spectrum5_000666
Sterogyl
Synthetic Vitamin D
UNII-VS041H42XC
Uvesterol D
Uvesterol-D
VITAMIN D2
VITAMIN D2 WATER DISPERSABLE U.S.P.
VITAMIN_D2
Vigantol
Vio D
Vio-D
Viostdrol
Viosterol
Viosterol in Oil
Vitamin D
Vitamin D2
Vitamin- D2
Vitamin-?D2
Vitamina D2
Vitavel-D
WLN: L56 FYTJ A1 BY1&1U1Y1&Y1&1 FU2U- BL6YYTJ AU1 DQ
ZINC04474571
ZINC04629876
beta-Ol
bmse000510
component of Geltabs Vitamin D
delta-Arthin
delta-Tracetten
ergocalciferol
vitamin d-2
6ErgocalciferolsPhase 4, Phase 3885
7vitamin dPhase 4, Phase 31463
8Vitamin D2NutraceuticalPhase 4, Phase 3885
9CalciferolNutraceuticalPhase 4, Phase 31028
10
Tenofovirapproved, investigationalPhase 3636147127-20-6464205
Synonyms:
(R)-9-(2-Phosphonomethoxypropyl)adenine
(R)-9-(2-Phosphonylmethoxypropyl)adenine
(R)-PMPA
147127-20-6
206184-49-8
AC-760
AC1LA9BO
Anh. tenofovir
Anhydrous tenofovir
Apropovir
CHEBI:45809
CHEMBL483
CID464205
D,L-Tenofovir
DB00300
GNA & Tenofovir
GS 1275
GS 1278
GS1278
HHA & Tenofovir
 
KS-5021
MolPort-003-850-411
NCGC00167535-01
PMPA
PMPA-(R)
Phosphonic acid, [[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]- & Galanthus nivalis agglutinin (GNA)
Phosphonic acid, [[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]- & Hippeastrum hybrid agglutinin( HHA)
Phosphonic acid, [[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]- (9CI)
Phosphonic acid, [[2-(6-amino-9H-purin-9
S1401_Selleck
TDF
TFV
Tenefovir
Tenofovir
Tenofovir (anh.)
Tenofovir Disoproxil Fumarate
Tenofovir disoproxil
Tenofovir disoproxil fumarate
UNII-99YXE507IL
Viread
Viread, Tenofovir
[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethylphosphonic acid
11
Emtricitabineapproved, investigationalPhase 3381143491-57-060877
Synonyms:
(-)-(2R,5S)-5-Fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine
(-)-(2R,5S)-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine
(-)-.beta.-L-FTC
(-)-2',3'-Dideoxy-5-fluoro-3'-thiacytidine
(-)-2'-Deoxy-5-fluoro-3'-thiacytidine
(-)-FTC
(-)-beta-2',3'-Dideoxy-5-fluoro-3'-thiacytidine
(-)-beta-2',3'-dideoxy-5-fluoro-3'-thiacytidine
(-)-cis-4-amino-5-Fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one
(-)-cis-4-amino-5-fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one
(2R-cis)-4-Amino-5-fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2(1H)-pyrimidinone
(2R-cis)-4-amino-5-Fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2(1H)-pyrimidinone
.beta.-L-(-)-(2R,5S)-5-Fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine
1-(2-(Hydroxymethyl)oxathiolan-5-yl)-5-fluorocytosine
143491-54-7
143491-57-0
145213-48-5
2',3',5-FTC
2',3'-Dideoxy-5-fluoro-3'-thiacytidine
2'-Deoxy-5-fluoro-3'-oxa-4'-thiocytidine
2'-Deoxy-5-fluoro-3'-thiacytidine
2-FTC
3'-Thia-2'.3'-dideoxy-5-fluorocytidine
4-Amino-5-fluoro-1-((2R,5S)-2-hydroxymethyl-[1,3]oxathiolan-5-yl)-1H-pyrimidin-2-one
4-Amino-5-fluoro-1-[(2R,5S)-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone
4-amino-5-Fluoro-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one
4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2(1H)-one
4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one
5-Fluoro-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine
5-Fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine
5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)[1,3]oxathiolan-5-yl]cytosine
524W91
AC1L1U3I
AC1Q4KUB
BW 1592
 
BW 524W91
BW-524W91
BW524W91
C122114
C12599
C8H10FN3O3S
CHEBI:31536
CHEMBL885
CID60877
Coviracil
Coviracil(TM)
D01199
DB00879
DRG-0208
Emtricitabin
Emtricitabina
Emtricitabine
Emtricitabine (JAN/USAN/INN)
Emtricitabinum
Emtriva
Emtriva (TN)
Emtriva(TM)
FT-0080009
HMS2089I05
HSDB 7337
LS-135838
LS-173184
NCGC00164564-01
RCV
Racivir
SBB066061
TL8000958
UNII-G70B4ETF4S
ZINC03629271
beta-L-2',3'-dideoxy-5-fluoro-3'-thiacytidine
dOTFC
emtricitabine
12Insulin, Globin ZincPhase 3, Phase 24069
13
Tenofovir disoproxilPhase 3636201341-05-15481350
Synonyms:
201341-05-1
9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)phosphinyl)methoxy)propyl)adenine
9-[(R)-2-[[Bis[[(isopropoxycarbonyl)oxy] methoxy]phosphinyl]methoxy]propyl]adenine
AC1NUKHG
Bis(POC)PMPA
Bis(isopropyloxymethylcarbonyl) 9-(2-phosphonomethoxypropyl)adenine
Bis(isopropyloxymethylcarbonyl)PMPA
CHEMBL1538
 
CID5481350
GS 4331-05 (*1:1 Fumarate salt*)
LS-187012
LS-187786
PMPA prodrug
ST51052782
TDF
Tenofovir disoproxil
Viread(TM) (*1:1 Fumarate salt*)
[[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-(propan-2-yloxycarbonyloxymethoxy)phosphoryl]oxymethyl propan-2-yl carbonate
14insulinPhase 3, Phase 24069
15Testosterone 17 beta-cypionatePhase 3457
16
Moxifloxacinapproved, investigationalPhase 2394354812-41-2152946
Synonyms:
(1'S,6'S)-1-Cyclopropyl-7-(2,8-diazabicyclo[4.3.0]non-8-yl)-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-((4aS,7aS)-octahydro-6H-pyrrolo(3,4-b)pyridin-6-yl)-4-oxo-3-quinolinecarboxylic acid
1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-((4as,7as)-octahydro-6H-pyrrolo(3,4-b)pyridin-6-yl)-4-oxo-3-quinolinecarboxylic acid
151096-09-2
186826-86-8
192927-63-2
7-[(4aS,7aS)-1,2,3,4,4a,5,7,7a-octahydropyrrolo[3,4-b]pyridin-6-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxoquinoline-3-carboxylic acid
AC1L49EP
Actira (*Hydrochloride*)
Avelox
Avelox (*Hydrochloride*)
Avelox I.V.
BAY 12-8039
BAY 12-8039 (*Hydrochloride*)
 
CCRIS 8690
CHEMBL32
CID152946
DB00218
I06-1961
LS-141510
MFX
MXF
MXFX
Moxeza
Moxifloxacin
Moxifloxacin Hydrochloride
Moxifloxacin [INN:BAN]
UNII-U188XYD42P
Vigamox
moxifloxacin
17Norgestimate, ethinyl estradiol drug combinationPhase 2394
18Contraceptives, Oral, CombinedPhase 2548
19
Quetiapineapproved400111974-69-75002
Synonyms:
111974-69-7
111974-72-2
2-(2-(4-Dibenzo(b,f)(1,4)thiazepin-11-yl-1-piperazinyl)ethoxy)ethanol
2-[2-(4-Dibenzo[b,F][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol
2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol
2-[2-(4-benzo[b][1,4]benzothiazepin-6-ylpiperazin-1-yl)ethoxy]ethanol
2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-ylpiperazin-1-yl)ethoxy]ethanol
2-{[2-(4-dibenzo[b,f][1,4]thiazepin-11-ylpiperazin-1-yl)ethyl]oxy}ethanol
AC1L1JE6
AKOS003588973
BIDD:GT0279
C07397
C21H25N3O2S
CHEBI:8707
CHEMBL716
CID5002
Co-Quetiapine
D08456
DB01224
HMS2093K06
HSDB 7557
I06-1980
ICI 204,636
InChI=1/C21H25N3O2S/c25-14-16-26-15-13-23-9-11-24(12-10-23)21-17-5-1-3-7-19(17)27-20-8-4-2-6-18(20)22-21/h1-8,25H,9-16H2
L001200
LS-172170
MLS001165710
 
MLS001195658
MolPort-002-506-329
MolPort-002-885-851
NCGC00095911-01
NCGC00095911-03
NCGC00095911-04
Norsic
Norsic (TN)
Quetiapin hemifumarate
Quetiapina
Quetiapine
Quetiapine (INN)
Quetiapine Fumarate
Quetiapine [INN:BAN]
Quetiapine fumarate
Quetiapine hemifumarate
Quetiapinum
SMR000550491
SPECTRUM1505187
Seroquel
Seroquel (Fumarate)
Seroquel XR
UNII-BGL0JSY5SI
ZD5077
ZINC19632628
ZM 204,636
quetiapina
quetiapine
quetiapinum
20Natriuretic Peptide, C-Type4
21Complement Factor I36
22Potassium iodate4
23cadexomer iodine425
24
Iodine4597553-56-2807
Synonyms:
I2
Iode
Iodine-molecule
 
Iodio
Iodum
Jod
Jood
Tincture iodine

Interventional clinical trials:

(show all 37)
idNameStatusNCT IDPhase
1Pilot Study of Bydureon to Treat Diabetes in HIV-infected AdultsCompletedNCT01791465Phase 4
2Effect of Vitamin D on Metabolic Parameters in Patients With the Metabolic SyndromeRecruitingNCT01237769Phase 4
3Analysis of Changes in Adipose Tissue of Patients With Lipoatrophy HIV Infection Treated With Nucleoside Thymidine, After Switching to Monotherapy With Lopinavir / RitonavirTerminatedNCT01031849Phase 4
4Low and Conventional Dose of Somatropin in Growth Hormone Deficient Adult PatientsCompletedNCT00570011Phase 3
5Hypovitaminosis D : A Link Between Bone/Mineral and Fat/Fuel MetabolismCompletedNCT01315366Phase 3
6Study Comparing Lopinavir/Ritonavir (LPV/r) + Emtricitabine/Tenofovir Disoproxil Fumarate (FTC/TDF) With a Nucleoside Sparing Regimen Consisting of Lopinavir/Ritonavir + Raltegravir (RAL)CompletedNCT00711009Phase 3
7Low-Dose Leptin and the Formerly-ObeseRecruitingNCT00073242Phase 3
8Effects of Interleukin-1 Beta on Low Testosterone Levels in Men With Obesity and Metabolic SyndromeRecruitingNCT02672592Phase 3
9Compassionate Use of Metreleptin in Previously Treated People With Partial LipodystrophyEnrolling by invitationNCT02262806Phase 3
10Trial of Leptin Administration After Roux-en-Y Gastric BypassCompletedNCT00710814Phase 1, Phase 2
11Leptin to Treat LipodystrophyCompletedNCT00005905Phase 2
12Leptin to Treat LipodystrophyCompletedNCT00025883Phase 2
13Effect of Leptin Therapy in the Treatment of Severe Insulin ResistanceRecruitingNCT00085982Phase 2
14Effects of Human Leptin ReplacementActive, not recruitingNCT00657605Phase 2
15Effects of Leptin Replacement in ChildrenActive, not recruitingNCT00659828Phase 2
16Study of Leptin for the Treatment of Hypothalamic AmenorrheaActive, not recruitingNCT00130117Phase 2
17Role of Leptin in the Neuroendocrine and Immune Response to FastingActive, not recruitingNCT00140231Phase 1, Phase 2
18Expanded Access Metreleptin StudyEnrolling by invitationNCT02404896Phase 2
19Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of RM-493 Administered to Healthy, Obese, Non-diabetic VolunteersCompletedNCT02431442Phase 1
20Pharmacokinetics of Leptin Administration During FastingActive, not recruitingNCT00140205Phase 1
21Recombinant Human Leptin Therapy Effects on Insulin ActionCompletedNCT01207934
22Adipocyte Function and Somtropin DeficiencyCompletedNCT01351818
23Iodine Supplementation in ObesityCompletedNCT01985204
24The Influence of Vitamin D on Atypical Antipsychotic-induced Weight GainCompletedNCT02281162
25Fatty Acid Oxidation Disorders & Body Weight Regulation GrantCompletedNCT00654004
26Vitamin D Supplementation in Psychiatric IllnessesCompletedNCT01004354
27Evaluating an Exercise Program to Reduce Cardiovascular Risk Factors in Children Infected With HIVCompletedNCT00908284
28Leptin for Abnormal Lipid Kinetics in HIV Lipodystrophy SyndromeCompletedNCT01511016
29Pharmacodynamics of CNP During Growth Hormone TreatmentCompletedNCT01504802
30Study of Metabolic Syndrome in Adolescent and Young Adult Survivors of Childhood Leukemia Who Have Undergone Stem Cell TransplantCompletedNCT00920842
31Evolution of Interleukin 7, Fat Mass and Metabolic Profile Before and After TransplantationCompletedNCT01414660
32Bone Mineral Density (BMD) in HIV InfectionCompletedNCT00146094
33Role of Vitamin D in the Prevention and Treatment of Diseases Associated With Insulin ResistanceRecruitingNCT01779908
34Lipophilic Micronutrients, Adipokines and Gestational Diabetes MellitusRecruitingNCT01678469
35Cardiovascular Consequences of NIV Withdrawal in Patients With Myotonic DystrophyRecruitingNCT00745238
36Correlation Between PTP1B Expression and Organ Failure During SepsisRecruitingNCT02295514
37Leptin in Human Energy and Neuroendocrine HomeostasisActive, not recruitingNCT00265980

Search NIH Clinical Center for Leptin Deficiency

Genetic Tests for Leptin Deficiency

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Genetic tests related to Leptin Deficiency:

id Genetic test Affiliating Genes
1 Leptin Deficiency22 LEP
2 Obesity, Severe, Due to Leptin Deficiency24

Anatomical Context for Leptin Deficiency

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MalaCards organs/tissues related to Leptin Deficiency:

33
Bone, T cells, Liver, Brain, Skin, Lymph node, Thyroid

Animal Models for Leptin Deficiency or affiliated genes

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MGI Mouse Phenotypes related to Leptin Deficiency:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.6GHR, IGF1, LEP, LEPR, NPPA
2MP:00053758.3GH1, GHR, IGF1, IGFBP4, LEP, LEPR
3MP:00053798.1GH1, GHR, IGF1, IGFBP4, LEP, LEPR
4MP:00053858.0GHR, IGF1, LEP, LEPR, NPPA, NPPB
5MP:00053697.7GHR, IGF1, IGFBP4, LEP, LEPR, NPPA

Publications for Leptin Deficiency

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Articles related to Leptin Deficiency:

(show top 50)    (show all 97)
idTitleAuthorsYear
1
Paradoxical Effects of Partial Leptin Deficiency on Bone in Growing Female Mice. (26370912)
2015
2
Genetically altering organismal metabolism by leptin-deficiency benefits a mouse model of amyotrophic lateral sclerosis. (24833719)
2014
3
Morbid obesity attenuates the skeletal abnormalities associated with leptin deficiency in mice. (24990938)
2014
4
Neonatal leptin deficiency reduces frontal cortex volumes and programs adult hyperactivity in mice. (24472638)
2014
5
Effects of leptin deficiency and replacement on cerebellar response to food-related cues. (22576622)
2013
6
Ablation of ghrelin O-acyltransferase does not improve glucose intolerance or body adiposity in mice on a leptin-deficient ob/ob background. (23630616)
2013
7
Leptin deficiency impairs maturation of dendritic cells and enhances induction of regulatory T and Th17 cells. (24271843)
2013
8
Leptin deficiency and diet-induced obesity reduce hypothalamic kisspeptin expression in mice. (21325051)
2011
9
Leptin deficiency and leptin gene mutations in obese children from Pakistan. (21854111)
2011
10
Leptin deficiency suppresses MMTV-Wnt-1 mammary tumor growth in obese mice and abrogates tumor initiating cell survival. (21636700)
2011
11
Short-term plasticity of gray matter associated with leptin deficiency and replacement. (21613360)
2011
12
Dynamics of plasma proteome during leptin-replacement therapy in genetically based leptin deficiency. (20458342)
2011
13
Congenital leptin deficiency: diagnosis and effects of leptin replacement therapy. (21340154)
2010
14
Congenital leptin deficiency and thyroid function. (19889232)
2009
15
Effects of leptin replacement on risk factors for cardiovascular disease in genetically leptin-deficient subjects. (18726825)
2009
16
Differences in trabecular bone of leptin-deficient ob/ob mice in response to biomechanical loading. (18566694)
2008
17
Leptin deficiency per se dictates body composition and insulin action in ob/ob mice. (18081560)
2008
18
Changes in insulin sensitivity during leptin replacement therapy in leptin-deficient patients. (18854428)
2008
19
Leptin selectively augments thymopoiesis in leptin deficiency and lipopolysaccharide-induced thymic atrophy. (16785512)
2006
20
Leptin deficiency causes pycnotic change in fetal cingulate cortical cells. (16643594)
2006
21
Activation of the cardiac ciliary neurotrophic factor receptor reverses left ventricular hypertrophy in leptin-deficient and leptin-resistant obesity. (16537512)
2006
22
Leptin deficiency unmasks the deleterious effects of impaired peroxisome proliferator-activated receptor gamma function (P465L PPARgamma) in mice. (17003330)
2006
23
Loss of resistin improves glucose homeostasis in leptin deficiency. (17065346)
2006
24
Effect of leptin replacement on brain structure in genetically leptin-deficient adults. (15713712)
2005
25
Long-term prospective and controlled studies demonstrate adipose tissue hypercellularity and relative leptin deficiency in the postobese state. (16131581)
2005
26
Leptin deficiency prevents the activation of the murine alpaha 2(I) collagen promoter by acetaldehyde. (15130784)
2004
27
Leptin deficiency enhances sensitivity of rats to alcoholic steatohepatitis through suppression of metallothionein. (15475485)
2004
28
Congenital leptin deficiency due to homozygosity for the Delta133G mutation: report of another case and evaluation of response to four years of leptin therapy. (15472169)
2004
29
Leptin deficiency enhances myocardial necrosis and lethality in a murine model of viral myocarditis. (15240179)
2004
30
The inhibition of growth hormone secretion presented in obesity is not mediated by the high leptin levels: a study in human leptin deficiency patients. (12519870)
2003
31
Leptin deficiency, not obesity, protects mice from Con A-induced hepatitis. (11828372)
2002
32
Murine leptin deficiency alters Kupffer cell production of cytokines that regulate the innate immune system. (12360490)
2002
33
Decreased gallbladder response in leptin-deficient obese mice. (12022998)
2002
34
Different presentation of bone mass in mice and humans with congenital leptin deficiency. (11836353)
2002
35
Leptin deficiency reduces but does not eliminate the development of hepatic fibrosis in mice infected with Schistosoma mansoni. (12028413)
2002
36
Partial leptin deficiency and human adiposity. (11689931)
2001
37
Insulin resistance associated with leptin deficiency in mice: a possible model for noninsulin-dependent diabetes mellitus. (11444594)
2001
38
Synchronicity of frequently sampled thyrotropin (TSH) and leptin concentrations in healthy adults and leptin-deficient subjects: evidence for possible partial TSH regulation by leptin in humans. (11443202)
2001
39
A cutaneous gene therapy approach to human leptin deficiencies: correction of the murine ob/ob phenotype using leptin-targeted keratinocyte grafts. (11427484)
2001
40
Human leptin deficiency and resistance. (11868884)
2001
41
Effects of leptin deficiency and short-term repletion on hepatic gene expression in genetically obese mice. (11574408)
2001
42
Leptin deficiency due to lipid apheresis: a possible reason for ravenous hunger and weight gain. (10702780)
2000
43
Human leptin deficiency and resistance. (11200911)
2000
44
Effect of leptin deficiency on metabolic rate in ob/ob mice. (10070008)
1999
45
Effects of recombinant leptin therapy in a child with congenital leptin deficiency. (10486419)
1999
46
Serum leptin levels in healthy ageing men: are decreased serum testosterone and increased adiposity in elderly men the consequence of leptin deficiency? (10468969)
1999
47
Effect of fasting and leptin deficiency on hypothalamic neuropeptide Y gene transcription in vivo revealed by expression of a lacZ reporter gene. (9564880)
1998
48
Absence of leptin deficiency mutation in extremely obese German children and adolescents. (9426388)
1997
49
Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance. (9177239)
1997
50
Congenital leptin deficiency is associated with severe early-onset obesity in humans. (9202122)
1997

Variations for Leptin Deficiency

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Expression for genes affiliated with Leptin Deficiency

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Search GEO for disease gene expression data for Leptin Deficiency.

Pathways for genes affiliated with Leptin Deficiency

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Pathways related to Leptin Deficiency according to GeneCards Suite gene sharing:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9LEP, LEPR
29.8NPPA, NPPB
39.7GH1, GHR
4
Show member pathways
9.5IGF1, LEP, LEPR
5
Show member pathways
9.5GH1, IGF1, LEP
69.5GH1, IGF1, LEP
79.3IGF1, NPPA, NPPB
89.3GH1, GHR, IGF1
9
Show member pathways
9.1GH1, GHR, LEP, LEPR
10
Show member pathways
8.9IGF1, IGFBP4, IGFBP6
118.9IGF1, IGFBP4, IGFBP6
12
Show member pathways
7.9GH1, IGF1, IGFBP4, IGFBP6, LEP, NPPA

GO Terms for genes affiliated with Leptin Deficiency

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Cellular components related to Leptin Deficiency according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056157.1GH1, GHR, IGF1, IGFBP4, IGFBP6, LEP
2extracellular regionGO:00055766.5GH1, GHR, IGF1, IGFBP4, IGFBP6, LEP

Biological processes related to Leptin Deficiency according to GeneCards Suite gene sharing:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1cGMP biosynthetic processGO:000618210.3NPPA, NPPB
2receptor guanylyl cyclase signaling pathwayGO:000716810.3NPPA, NPPB
3regulation of blood vessel sizeGO:005088010.2NPPA, NPPB
4JAK-STAT cascade involved in growth hormone signaling pathwayGO:006039710.2GH1, GHR
5bone mineralization involved in bone maturationGO:003563010.2IGF1, LEP
6growth hormone receptor signaling pathwayGO:006039610.2GH1, GHR
7JAK-STAT cascadeGO:000725910.2GH1, GHR
8insulin-like growth factor receptor signaling pathwayGO:004800910.1GHR, IGF1
9regulation of insulin-like growth factor receptor signaling pathwayGO:00435679.9IGFBP4, IGFBP6
10positive regulation of multicellular organism growthGO:00400189.8GH1, GHR
11positive regulation of tyrosine phosphorylation of Stat5 proteinGO:00425239.8GH1, GHR, IGF1
12positive regulation of insulin-like growth factor receptor signaling pathwayGO:00435689.7GH1, IGF1, IGFBP4
13regulation of multicellular organism growthGO:00400149.6GHR, IGF1
14positive regulation of JAK-STAT cascadeGO:00464279.5GH1, GHR, LEP
15positive regulation of MAPK cascadeGO:00434109.4IGF1, IGFBP4, LEP
16positive regulation of tyrosine phosphorylation of Stat3 proteinGO:00425179.4GH1, GHR, LEP
17positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.2GH1, GHR, IGF1
18regulation of blood pressureGO:00082179.2LEP, NPPA, NPPB

Molecular functions related to Leptin Deficiency according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1peptide hormone receptor bindingGO:005142810.3LEP, NPPA
2cytokine receptor activityGO:00048969.9GHR, LEPR
3insulin-like growth factor I bindingGO:00319949.8IGFBP4, IGFBP6
4insulin-like growth factor II bindingGO:00319959.8IGFBP4, IGFBP6
5growth factor activityGO:00080839.5GH1, IGF1, LEP
6insulin-like growth factor bindingGO:00055209.0IGFBP4, IGFBP6
7hormone activityGO:00051798.9GH1, IGF1, LEP, NPPA, NPPB

Sources for Leptin Deficiency

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet