MCID: LPT005
MIFTS: 30

Leptin Deficiency malady

Summaries for Leptin Deficiency

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63Wikipedia, 32MalaCards
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Wikipedia:63 Leptin (from Greek λεπτός leptos, \"thin\") is a 16-kDa adipokine that plays a key role in... more...

MalaCards: Leptin Deficiency is related to obesity and hepatitis. An important gene associated with Leptin Deficiency is LEP (leptin), and among its related pathways are Development Leptin signaling via JAK/STAT and MAPK cascades and Adipocytokine signaling pathway. The compounds estradiol and norepinephrine have been mentioned in the context of this disorder. Related mouse phenotypes are liver/biliary system and adipose tissue.

Aliases & Classifications for Leptin Deficiency

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20GeneTests
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Aliases & Descriptions:

leptin deficiency 20


Related Diseases for Leptin Deficiency

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17GeneCards, 18GeneDecks
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Diseases related to Leptin Deficiency via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 104)
idRelated DiseaseScoreTop Affiliating Genes
1obesity30.8CCK, LSL, NPY, PPARG, GH1, CNTFR
2hepatitis30.2IL18
3hypogonadism30.2LEP, GH1, LSL
4diabetes mellitus30.1CCK, LSL, NPY, PPARG, GH1, LEP
5pancreatitis29.9CCK
6acute pancreatitis29.9CCK, IL18
7morbid obesity29.9LEPR, LEP, LSL, CCK
8fatty liver disease29.9LEPR, LEP, PPARG, LSL
9atherosclerosis29.9LEPR, LEP, IL18, PPARG, LSL
10glucose intolerance29.8LSL, NPY, PPARG, GH1, LEP, LEPR
11congenital leptin deficiency10.5
12t cell deficiency10.1
13amenorrhea10.0LEP
14allergic rhinitis10.0IL18
15rhinitis10.0NPY
16acanthosis nigricans10.0LEP
17adenocarcinoma10.0CCK
18huntington's disease10.0NPY
19alcohol dependence10.0NPY
20asthma10.0IL18
21thyroid cancer10.0PPARG
22endometriosis10.0LEPR
23lupus erythematosus10.0IL18
24peptic ulcer10.0CCK
25nephrotic syndrome10.0LEPR
26constipation10.0CCK
27panic disorder10.0CCK
28dermatitis10.0IL18
29myoma10.0LEPR
30severe pre-eclampsia10.0LEP, LSL
31hypothyroidism10.0LSL, LEP
32hepatocellular carcinoma10.0LEPR
33myocardial infarction10.0NPY, LSL
34familial partial lipodystrophy10.0PPARG, LEP
35relapsing-remitting multiple sclerosis10.0IL18, LSL
36osteoarthritis10.0IL18, NPY
37laron syndrome10.0GH1
38schizophrenia10.0NPY, CCK
39neuroepithelioma10.0NPY, CCK
40leukemia10.0CNTFR, LEPR
41hepatitis c10.0LEPR, IL18
42cholestasis10.0CCK
43coronary heart disease10.0LEP, IL18, NPY
44proteinuria10.0LSL
45congenital generalized lipodystrophy type 210.0LSL, PPARG, LEP
46metabolic syndrome x10.0LSL, PPARG, LEP
47hypertriglyceridemia10.0LSL, PPARG, LEP
48protein-energy malnutrition10.0LEP, LSL, CCK
49adrenal gland hyperfunction10.0GH1, LEP
50familial hyperlipidemia10.0LEP, PPARG, LSL

Graphical network of the top 20 diseases related to Leptin Deficiency:



Diseases related to leptin deficiency

Clinical Features for Leptin Deficiency

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Drugs & Therapeutics for Leptin Deficiency

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Leptin Deficiency

Drug clinical trials:

Search ClinicalTrials for Leptin Deficiency

Search NIH Clinical Center for Leptin Deficiency

Search CenterWatch for Leptin Deficiency

Genetic Tests for Leptin Deficiency

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20GeneTests
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Genetic tests related to Leptin Deficiency:

id Genetic test Affiliating Genes
1 Leptin Deficiency20 LEP

Anatomical Context for Leptin Deficiency

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Animal Models for Leptin Deficiency or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Leptin Deficiency:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.3NPY, PPARG, GH1, LEP, LEPR
2MP:00053758.3LEPR, NPY, PPARG, GH1, IL18, LEP
3MP:00053768.0LEPR, LEP, IL18, GH1, PPARG, NPY
4MP:00036317.3CCK, NPY, PPARG, GH1, CNTFR, IL18

Publications for Leptin Deficiency

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Genetic Variations for Leptin Deficiency

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Expression for genes affiliated with Leptin Deficiency

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Leptin Deficiency

Search GEO for disease gene expression data for Leptin Deficiency.

Pathways for genes affiliated with Leptin Deficiency

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Sources:
12EMD Millipore, 29KEGG, 51QIAGEN, 37NCBI BioSystems Database, 53Reactome
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Pathways related to Leptin Deficiency according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Development Leptin signaling via JAK/STAT and MAPK cascades
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9.8LEPR, LEP
29.5LEPR, LEP, NPY
3
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9.5CNTFR, LEPR
4
Development Prolactin receptor signaling
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9.4LEPR, LEP, GH1
58.8GH1, CNTFR, LEP, LEPR
6
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8.7CCK, NPY, GH1, LEP, LEPR
78.7LEP, CNTFR, GH1, PPARG

Compounds for genes affiliated with Leptin Deficiency

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB
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Compounds related to Leptin Deficiency according to GeneCards/GeneDecks:

(show top 50)    (show all 96)
idCompoundScoreTop Affiliating Genes
1estradiol44 11 2412.4LEPR
2norepinephrine44 11 2412.2NPY, CCK
3gnrh4410.1GH1, LEPR
4[met]enkephalin4410.0CCK, NPY
5enterostatin449.9CCK, NPY, LEP
6alpha msh449.9CCK, NPY, LEP
7fenfluramine28 44 1111.8CCK, NPY, LEP
8oxyntomodulin44 5910.8LEP, NPY, CCK
9sulpiride44 28 1111.8NPY, GH1, LEP
10dexamethasone44 49 28 1112.8LEPR, GH1, CCK
11sibutramine44 1110.7LSL, NPY, LEP
12lep (116-130) (mouse)599.7LEPR, LEP
13beta-hydroxybutyrate449.6LEP, GH1, LSL
14nash449.6LSL, LEP, LEPR
15acipimox44 2810.6LEP, GH1, LSL
16naloxone44 49 28 1112.4LEP, GH1, CCK
17sodium nitroprusside449.4CCK, NPY, GH1, LEP
18cocaine44 1110.4CCK, NPY, LEP, LEPR
19l-nmma449.4LEP, GH1, PPARG, CCK
20intralipid449.4CCK, LSL, GH1, LEP
21c-peptide449.3LEP, GH1, LSL, CCK
22fatty acid449.3LEPR, PPARG, LSL
23octreotide44 59 28 1112.3GH1, NPY, LSL, CCK
24pravastatin44 49 28 11 2413.3LSL, PPARG, IL18, LEP
25triiodothyronine449.3LSL, GH1, LEP, LEPR
26androstenedione44 2410.2LSL, GH1, LEP, LEPR
27carbohydrates449.2CCK, LSL, NPY, LEP
28prednisolone44 28 1111.2LSL, NPY, GH1, IL18
29metformin44 49 1111.2LSL, PPARG, GH1, LEP
30indomethacin44 59 28 1112.1NPY, PPARG, GH1, IL18, LEP
31epinephrine44 11 2411.0LEP, IL18, GH1, NPY, LSL
32corticosterone44 59 2411.0LEPR, LEP, GH1, NPY, LSL
33orlistat44 59 1111.0LEP, PPARG, NPY, LSL, CCK
34rosiglitazone44 49 28 11 2412.9LSL, PPARG, GH1, IL18, LEP
35glucose448.9CCK, LSL, NPY, PPARG, LEPR
36glycerol44 11 2410.9CCK, LSL, PPARG, GH1, LEP
37creatinine448.8LEP, IL18, GH1, NPY, LSL
38glutamine448.7CCK, NPY, PPARG, GH1, IL18, LEPR
39acth448.7CCK, LSL, NPY, GH1, LEP, LEPR
40methotrexate44 49 1110.7LSL, GH1, IL18, LEP
41acetylcholine44 49 28 11 2412.6CCK, NPY, GH1, CNTFR, IL18, LEP
42alanine448.6LSL, NPY, PPARG, GH1, LEPR
43thyroxine44 249.6LSL, NPY, PPARG, GH1, LEP, LEPR
44heparin44 28 11 2411.4LSL, NPY, GH1, FGF19, LEP
45vegf448.4LSL, PPARG, GH1, IL18, LEP, LEPR
46arginine448.3CCK, LSL, NPY, GH1, IL18, LEP
47cholesterol44 28 11 2411.1CCK, LSL, PPARG, FGF19, IL18, LEP
48retinoic acid44 249.1CCK, NPY, PPARG, GH1, CNTFR, IL18
49testosterone44 59 11 2410.9CCK, LSL, NPY, PPARG, GH1, IL18
50lipid447.4LSL, PPARG, GH1, CNTFR, FGF19, IL18

GO Terms for genes affiliated with Leptin Deficiency

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16Gene Ontology
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Cellular components related to Leptin Deficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.8LEP, IL18, GH1, NPY, CCK
2extracellular regionGO:0055767.6LEPR, CCK, NPY, GH1, FGF19, IL18

Biological processes related to Leptin Deficiency according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of appetiteGO:03209910.0LEP, CCK
2adult feeding behaviorGO:00834310.0LEP, NPY
3central nervous system neuron developmentGO:0219549.9LEP, NPY
4eating behaviorGO:0427559.7CCK, LEP
5response to coldGO:0094099.7IL18, PPARG
6regulation of blood pressureGO:0082179.6LEP, PPARG, NPY
7positive regulation of tyrosine phosphorylation of Stat3 proteinGO:0425179.5LEP, GH1
8positive regulation of cell proliferationGO:0082848.8CCK, CNTFR, FGF19, LEP

Molecular functions related to Leptin Deficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:0051849.8NPY, CCK
2hormone activityGO:0051799.3LEP, GH1, CCK
3growth factor activityGO:0080839.0LEP, FGF19, GH1

Products for genes affiliated with Leptin Deficiency

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Leptin Deficiency

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet