MCID: LPT006
MIFTS: 27

Leptin Receptor Deficiency malady

Genetic diseases, Reproductive diseases, Endocrine diseases, Rare diseases categories

Summaries for Leptin Receptor Deficiency

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66Wikipedia, 48OMIM, 34MalaCards
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Wikipedia:66 Leptin receptor also known as LEP-R is a protein that in humans is encoded by the LEPR gene. LEP-R... more...

MalaCards: Leptin Receptor Deficiency, also known as obesity, morbid, due to leptin receptor deficiency, is related to obesity and hypertension. An important gene associated with Leptin Receptor Deficiency is LEPR (leptin receptor). Affiliated tissues include brain and hypothalamus.

Description from OMIM:48 614963

Aliases & Classifications for Leptin Receptor Deficiency

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21GeneTests, 23GTR, 22Genetics Home Reference, 50Orphanet, 48OMIM, 27ICD10 via Orphanet
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Classifications:



Aliases & Descriptions:

leptin receptor deficiency 21 23 22
obesity, morbid, due to leptin receptor deficiency 22 48
obesity due to leptin receptor gene deficiency 22 50
congenital deficiency of the leptin receptor 22
leptin receptor-related monogenic obesity 22
obesity, morbid, nonsyndromic 2 22


External Ids:

OMIM48 614963
ICD10 via Orphanet27 E66.8

Related Diseases for Leptin Receptor Deficiency

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18GeneCards, 19GeneDecks
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Diseases related to Leptin Receptor Deficiency via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1obesity10.4
2hypertension10.1
3autonomic dysfunction10.1

Symptoms for Leptin Receptor Deficiency

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48OMIM
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Clinical features from OMIM:

614963

Drugs & Therapeutics for Leptin Receptor Deficiency

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Leptin Receptor Deficiency

Drug clinical trials:

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Search NIH Clinical Center for Leptin Receptor Deficiency

Search CenterWatch for Leptin Receptor Deficiency

Genetic Tests for Leptin Receptor Deficiency

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21GeneTests, 23GTR
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Genetic tests related to Leptin Receptor Deficiency:

id Genetic test Affiliating Genes
1 Leptin Receptor Deficiency21 23 LEPR

Anatomical Context for Leptin Receptor Deficiency

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34MalaCards
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MalaCards organs/tissues related to Leptin Receptor Deficiency:

34
Brain, Hypothalamus

Animal Models for Leptin Receptor Deficiency or affiliated genes

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Publications for Leptin Receptor Deficiency

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53PubMed
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Articles related to Leptin Receptor Deficiency:

(show all 11)
idTitleAuthorsYear
1
Haematopoietic leptin receptor deficiency does not affect macrophage accumulation in adipose tissue or systemic insulin sensitivity. (22194312)
2012
2
Increased central and peripheral inflammation and inflammatory hyperalgesia in Zucker rat model of leptin receptor deficiency and genetic obesity. (22523380)
2012
3
Neuropeptide Y and agouti-related peptide mediate complementary functions of hyperphagia and reduced energy expenditure in leptin receptor deficiency. (21285324)
2011
4
Bromocriptine administration reduces hyperphagia and adiposity and differentially affects dopamine D2 receptor and transporter binding in leptin-receptor-deficient Zucker rats and rats with diet-induced obesity. (18984941)
2009
5
The effect of leptin receptor deficiency and fasting on cannabinoid receptor 1 mRNA expression in the rat hypothalamus, brainstem and nodose ganglion. (19596404)
2009
6
Diabetic hypertensive leptin receptor-deficient db/db mice develop cardioregulatory autonomic dysfunction. (19029483)
2009
7
Leptin receptor deficiency is associated with upregulation of cannabinoid 1 receptors in limbic brain regions. (18563836)
2008
8
Indirect effects of leptin receptor deficiency on lymphocyte populations and immune response in db/db mice. (16920925)
2006
9
Transgenic complementation of leptin receptor deficiency. II. Increased leptin receptor transgene dose effects on obesity/diabetes and fertility/lactation in lepr-db/db mice. (14600075)
2004
10
Leptin receptor-deficient MMTV-TGF-alpha/Lepr(db)Lepr(db) female mice do not develop oncogene-induced mammary tumors. (14734797)
2004
11
Transgenic complementation of leptin-receptor deficiency. I. Rescue of the obesity/diabetes phenotype of LEPR-null mice expressing a LEPR-B transgene. (11272157)
2001

Variations for Leptin Receptor Deficiency

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Expression for genes affiliated with Leptin Receptor Deficiency

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Leptin Receptor Deficiency

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Pathways for genes affiliated with Leptin Receptor Deficiency

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Compounds for genes affiliated with Leptin Receptor Deficiency

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GO Terms for genes affiliated with Leptin Receptor Deficiency

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Products for genes affiliated with Leptin Receptor Deficiency

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Leptin Receptor Deficiency

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet