MCID: LPT007
MIFTS: 12

Leptomeningeal Amyloidosis malady

Summaries for Leptomeningeal Amyloidosis

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33MalaCards
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MalaCards: Leptomeningeal Amyloidosis, also known as amyloidosis, leptomeningeal, is related to amyloidosis and al amyloidosis. An important gene associated with Leptomeningeal Amyloidosis is TTR (transthyretin). Affiliated tissues include brain.

Aliases & Classifications for Leptomeningeal Amyloidosis

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20GeneTests, 45Novoseek
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Aliases & Descriptions:

leptomeningeal amyloidosis 20
amyloidosis, leptomeningeal 45


Related Diseases for Leptomeningeal Amyloidosis

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17GeneCards, 18GeneDecks
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Diseases related to Leptomeningeal Amyloidosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1amyloidosis10.6
2al amyloidosis10.2
3siderosis10.1
4hereditary amyloidosis10.1
5superficial siderosis10.1

Graphical network of diseases related to Leptomeningeal Amyloidosis:



Diseases related to leptomeningeal amyloidosis

Clinical Features for Leptomeningeal Amyloidosis

Drugs & Therapeutics for Leptomeningeal Amyloidosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Leptomeningeal Amyloidosis

Drug clinical trials:

Search ClinicalTrials for Leptomeningeal Amyloidosis

Search NIH Clinical Center for Leptomeningeal Amyloidosis

Search CenterWatch for Leptomeningeal Amyloidosis

Genetic Tests for Leptomeningeal Amyloidosis

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20GeneTests
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Genetic tests related to Leptomeningeal Amyloidosis:

id Genetic test Affiliating Genes
1 Leptomeningeal Amyloidosis20

Anatomical Context for Leptomeningeal Amyloidosis

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33MalaCards
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MalaCards organs/tissues related to Leptomeningeal Amyloidosis:

33
Brain

Animal Models for Leptomeningeal Amyloidosis or affiliated genes

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28inGenious Targeting Laboratory
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Publications for Leptomeningeal Amyloidosis

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51PubMed
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Articles related to Leptomeningeal Amyloidosis:

(show all 12)
idTitleAuthorsYear
1
Doxycycline in ATTRY69H (p.ATTRY89H) amyloidosis with predominant leptomeningeal manifestation. (24047503)
2013
2
Leptomeningeal amyloidosis due to A25T TTR mutation: a case report. (23465688)
2013
3
Deposition of collagen IV and aggrecan in leptomeningeal arteries of hereditary brain haemorrhage with amyloidosis. (23973860)
2013
4
A new transthyretin mutation associated with leptomeningeal amyloidosis. (21838472)
2011
5
Dissecting the structure, thermodynamic stability, and aggregation properties of the A25T transthyretin (A25T-TTR) variant involved in leptomeningeal amyloidosis: identifying protein partners that co-aggregate during A25T-TTR fibrillogenesis in cerebrospinal fluid. (22091638)
2011
6
Highly selective leptomeningeal amyloidosis with transthyretin variant Ala25Thr. (19365058)
2009
7
A new Thr49Pro transthyretin gene mutation associated with leptomeningeal amyloidosis. (18579156)
2008
8
A case of biopsy-proven leptomeningeal amyloidosis and intravenous Ig-responsive polyneuropathy associated with the Ala25Thr transthyretin gene mutation. (16690499)
2006
9
Biochemical characteristics of variant transthyretins causing hereditary leptomeningeal amyloidosis. (16399646)
2005
10
Familial leptomeningeal amyloidosis with a transthyretin variant Asp18Gly representing repeated subarachnoid haemorrhages with superficial siderosis. (15377697)
2004
11
Transthyretin Leu12Pro is associated with systemic, neuropathic and leptomeningeal amyloidosis. (10071047)
1999
12
Massive leptomeningeal amyloidosis associated with a Val30Met transthyretin gene. (8857732)
1996

Genetic Variations for Leptomeningeal Amyloidosis

Expression for genes affiliated with Leptomeningeal Amyloidosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Leptomeningeal Amyloidosis

Search GEO for disease gene expression data for Leptomeningeal Amyloidosis.

Pathways for genes affiliated with Leptomeningeal Amyloidosis

Compounds for genes affiliated with Leptomeningeal Amyloidosis

GO Terms for genes affiliated with Leptomeningeal Amyloidosis

Products for genes affiliated with Leptomeningeal Amyloidosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Leptomeningeal Amyloidosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet