MCID: LPT001
MIFTS: 46

Leptospirosis malady

Rare diseases, Infectious diseases categories

Aliases & Classifications for Leptospirosis

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 11DISEASES, 43Novoseek, 47Orphanet, 3CDC, 60UMLS, 38NCIt, 27ICD9CM, 55SNOMED-CT, 33MeSH, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Leptospirosis, Aliases & Descriptions:

Name: Leptospirosis 9 41 11 43 47 3 60
Hemorrhagic Jaundice 41 60
Fort Bragg Fever 9 60
Canicola Fever 41 60
Weil Disease 41 60
Leptospirosis Icterohaemorrhagica 9
Leptospirosis Icterohemorrhagica 9
Equine Infectious Anemia 60
Icterohemorrhagic Fever 41
Rat Catcher's Yellows 9
Spirochetal Jaundice 9
 
Canine Leptospirosis 60
Swineherd's Disease 41
Stuttgart Disease 41
Cane-Cutter Fever 41
Rice-Field Fever 41
Nanukayami Fever 9
Weil's Disease 9
Swamp Fever 41
Leptospiral 9
Nanukayami 60
Mud Fever 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases


Characteristics (Orphanet epidemiological data):

47
leptospirosis:
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: All ages; Age of death: normal life expectancy


External Ids:

Disease Ontology9 DOID:2297
NCIt38 C84825
ICD9CM27 100, 100.9
MeSH33 D007922
Orphanet47 509
MESH via Orphanet34 D007922
ICD10 via Orphanet26 A27.0, A27.8, A27.9
UMLS via Orphanet61 C0023364
ICD1025 A27, A27.0, A27.9

Summaries for Leptospirosis

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Disease Ontology:9 A primary bacterial infectious disease that involves systemic infection, has material basis in leptospira, which is transmitted by contact with water, food, or soil containing urine from the infected animals. the infection has symptom jaundice, has symptom chills, has symptom fever, has symptom muscle pain, and has symptom hepatomegaly.

MalaCards based summary: Leptospirosis, also known as hemorrhagic jaundice, is related to influenza and typhus, and has symptoms including jaundice, chills and fever. An important gene associated with Leptospirosis is OMP (olfactory marker protein), and among its related pathways are Signaling by FGFR and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. The compound mannan have been mentioned in the context of this disorder. Affiliated tissues include kidney, lung and testes.

Wikipedia:63 Leptospirosis (also known as field fever,rat catcher\'s yellows, and pretibial fever among others names)... more...

Related Diseases for Leptospirosis

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Graphical network of the top 20 diseases related to Leptospirosis:



Diseases related to leptospirosis

Symptoms for Leptospirosis

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Symptoms:

 9
  • jaundice
  • chills
  • fever
  • muscle pain
  • hepatomegaly

Drugs & Therapeutics for Leptospirosis

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Drug clinical trials:

Search ClinicalTrials for Leptospirosis

Search NIH Clinical Center for Leptospirosis

Genetic Tests for Leptospirosis

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Anatomical Context for Leptospirosis

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MalaCards organs/tissues related to Leptospirosis:

31
Kidney, Lung, Testes, Heart, Liver, Eye, Whole blood, Skin, T cells, B cells

Animal Models for Leptospirosis or affiliated genes

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Publications for Leptospirosis

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Articles related to Leptospirosis:

(show top 50)    (show all 610)
idTitleAuthorsYear
1
Atypical manifestations of leptospirosis. (25813883)
2015
2
Seroprevalence study of leptospirosis among rice farmers in khuzestan province, South west iran, 2012. (25368799)
2014
3
Seroepidemiology of leptospirosis in dogs and rats in Trinidad. (25776612)
2014
4
Leptospirosis in sheep and goats under tropical conditions. (24085419)
2013
5
Signalment Changes in Canine Leptospirosis between 1970 and 2009. (24372922)
2013
6
Outbreak of leptospirosis among canyoning participants, Martinique, 2011. (23725775)
2013
7
Molecular typing of Leptospira spp. strains isolated from field mice confirms a link to human leptospirosis. (23406882)
2013
8
A conserved region of leptospiral immunoglobulin-like A and B proteins as a DNA vaccine elicits a prophylactic immune response against leptospirosis. (23486420)
2013
9
Plasma exchange in severe leptospirosis with multi-organ failure: a case report. (23809518)
2013
10
Antimicrobial Prophylaxis For Melioidosis and Leptospirosis For At Risk Rescue Workers. (23466779)
2013
11
Severe Pulmonary Involvement in Leptospirosis: Alternate antibiotics and systemic steroids. (23862041)
2013
12
Flock-level risk factors associated with leptospirosis in dairy goats in a semiarid region of Northeastern Brazil. (23031326)
2013
13
Human hemorrhagic pulmonary leptospirosis: pathological findings and pathophysiological correlations. (23951234)
2013
14
Application of an integrated outbreak management plan for the control of leptospirosis in dairy cattle herds. (23920354)
2013
15
Microhaemorrhages in Leptospirosis on susceptibility weighted imaging. (22285590)
2012
16
Modeling seasonal leptospirosis transmission and its association with rainfall and temperature in Thailand using time-series and ARIMAX analyses. (22647816)
2012
17
The dog in the transmission of human leptospirosis under tropical conditions: victim or villain? (21396149)
2012
18
Evaluation of 'white-spotted kidneys' associated with leptospirosis by polymerase chain reaction based LipL32 gene in slaughtered cows. (23327135)
2012
19
Cases distribution of leptospirosis in City of Manaus, State of Amazonas, Brazil, 2000-2010. (23295874)
2012
20
Serology and PCR for bovine leptospirosis: herd and individual approaches. (22427387)
2012
21
Outbreak of melioidosis and leptospirosis co-infection following a rescue operation. (23082420)
2012
22
Severe leptospirosis in a Dutch traveller returning from the Dominican Republic, October 2011. (22490382)
2012
23
Leptospirosis diagnosis by immunocapture polymerase chain reaction: a new tool for early diagnosis and epidemiologic surveillance. (22770775)
2012
24
Differences between seroreactivity to leptospirosis in dairy and beef cattle from the same herd in Rio de Janeiro, Brazil. (21739134)
2012
25
Paralysis due to renal hypokalaemia: an unusual presentation of leptospirosis. (22715569)
2012
26
Antibiotics for leptospirosis. (22336839)
2012
27
A sensitive and specific IgM-ELISA for the serological diagnosis of human leptospirosis using a rLipL32/1-LipL21-OmpL1/2 fusion protein. (21784316)
2011
28
Vaccination for leptospirosis improved the weaning percentage of 2-year-old farmed red deer hinds in New Zealand. (21660849)
2011
29
Sporadic urban leptospirosis. (23882321)
2011
30
Serological evidence of Thailand virus-related hantavirus infection among suspected leptospirosis patients in Kandy, Sri Lanka. (21266762)
2011
31
Travel-related leptospirosis in Israel: a nationwide study. (20207873)
2010
32
Differential cytokine gene expression according to outcome in a hamster model of leptospirosis. (20076757)
2010
33
The contribution of bats to leptospirosis transmission in Sao Paulo City, Brazil. (20134010)
2010
34
Evaluation of a recombinant LigB protein of Leptospira interrogans serovar Canicola in an enzyme-linked immunosorbent assay for the serodiagnosis of bovine leptospirosis. (20022618)
2010
35
Serodiagnosis of bovine leptospirosis by IgG-enzyme-linked immunosorbent assay and latex agglutination test. (19680775)
2010
36
Leptospirosis-associated acute kidney injury. (21541455)
2010
37
Leptospirosis pulmonary haemorrhage syndrome is associated with linear deposition of immunoglobulin and complement on the alveolar surface. (19778300)
2010
38
Leptospirosis: a globally increasing zoonotic disease. (22791852)
2010
39
A case of severe leptospirosis infection (Weil's disease) in Tokyo]. (20170016)
2010
40
Leptospirosis in a European intensive care unit. (19883151)
2010
41
Vasculitis secondary to presumptive leptospirosis treated with long-term corticosteroids in a captive lesser kudu (Tragelaphus imberbis australis). (20945659)
2010
42
Seasonal and environmental determinants of leptospirosis and scrub typhus in small mammals captured at a U.S. military training site (Dagmar North), Republic of Korea, 2001-2004. (19891218)
2009
43
Leptospirosis distribution related to freshwater habitats in the Vojvodina region (Republic of Serbia). (19911133)
2009
44
Evaluation of surveillance case definition in the diagnosis of leptospirosis, using the Microscopic Agglutination Test: a validation study. (19386085)
2009
45
Leptospirosis: a worldwide resurgent zoonosis and important cause of acute renal failure and death in developing nations. (19484873)
2009
46
Increase in seroprevalence of canine leptospirosis and its risk factors, Ontario 1998-2006. (19794888)
2009
47
Evaluation of recombinant Leptospira antigen-based enzyme-linked immunosorbent assays for the serodiagnosis of leptospirosis. (11526167)
2001
48
Acute acalculous cholecystitis in leptospirosis. (10509958)
1999
49
Leptospirosis with acute acalculous cholecystitis and pancreatitis. (8421147)
1993
50
Occurrence of antibodies to the etiologic agents of infectious bovine rhinotracheitis, parainfluenza 3, leptospirosis, and brucellosis in white-tailed deer in Minnesota. (3005666)
1986

Variations for Leptospirosis

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Expression for genes affiliated with Leptospirosis

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Search GEO for disease gene expression data for Leptospirosis.

Pathways for genes affiliated with Leptospirosis

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Pathways related to Leptospirosis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
7.6KIR3DS1, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DS3
27.4KIR2DS3, KIR2DL3, KIR2DL2, KIR2DL4, KIR2DL1, CD40LG
3
Show member pathways
7.4KIR2DS3, KIR2DL3, KIR2DL2, KIR2DL4, KIR2DL1, CD40LG
4
Show member pathways
Immune response CD16 signaling in NK cells58
7.4KIR2DS3, KIR2DL3, KIR2DL2, KIR2DL4, KIR2DL5A, KIR2DL1
5
Show member pathways
7.0CD40LG, KIR2DS3, KIR2DL3, KIR2DL2, KIR2DL4, KIR2DL5A

Compounds for genes affiliated with Leptospirosis

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Sources:
43Novoseek
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Compounds related to Leptospirosis according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1mannan439.7CD40LG, KIR2DL2

GO Terms for genes affiliated with Leptospirosis

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Cellular components related to Leptospirosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:00058876.9CD40LG, KIR3DS1, KIR2DL1, KIR2DL4, KIR2DL3, KIR2DS3
2plasma membraneGO:00058866.8KIR2DL2, KIR2DL4, KIR2DL5A, KIR2DL1, KIR3DS1, CD40LG

Biological processes related to Leptospirosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cellular defense responseGO:00069689.2KIR2DL4, KIR2DS3
2signal transductionGO:00071659.0KIR3DS1, KIR2DL4, OMP
3immune responseGO:00069558.4KIR2DL3, KIR2DL1, KIR3DS1
4regulation of immune responseGO:00507767.8CD40LG, KIR2DL1, KIR2DL4, KIR2DL2, KIR2DL3

Molecular functions related to Leptospirosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1receptor activityGO:00048729.1KIR2DL1, KIR2DL3

Products for genes affiliated with Leptospirosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Leptospirosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet