MCID: LPT001
MIFTS: 62

Leptospirosis malady

Categories: Rare diseases, Infectious diseases, Skin diseases

Aliases & Classifications for Leptospirosis

Aliases & Descriptions for Leptospirosis:

Name: Leptospirosis 12 50 56 52 3 42 14 69
Weil Disease 50 42 69
Hemorrhagic Jaundice 50 69
Stuttgart Disease 50 69
Fort Bragg Fever 12 69
Canicola Fever 50 69
Leptospirosis Icterohaemorrhagica 12
Equine Infectious Anemia 69
Icterohemorrhagic Fever 50
Rat Catcher's Yellows 12
Spirochetal Jaundice 12
Canine Leptospirosis 69
Swineherd's Disease 50
Cane-Cutter Fever 50
Nanukayami Fever 12
Rice-Field Fever 50
Weil's Disease 12
Swamp Fever 50
Nanukayami 69
Mud Fever 50

Characteristics:

Orphanet epidemiological data:

56
leptospirosis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 56  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:2297
ICD10 33 A27 A27.0 A27.9
ICD9CM 35 100 100.0 100.9
NCIt 47 C84825
Orphanet 56 ORPHA509
ICD10 via Orphanet 34 A27.8 A27.9 A27.0
MESH via Orphanet 43 D007922
UMLS via Orphanet 70 C0023364

Summaries for Leptospirosis

Disease Ontology : 12 A primary bacterial infectious disease that involves systemic infection, has material basis in Leptospira, which is transmitted_by contact with water, food, or soil containing urine from the infected animals. The infection has symptom jaundice, has symptom chills, has symptom fever, has symptom muscle pain, and has symptom hepatomegaly.

MalaCards based summary : Leptospirosis, also known as weil disease, is related to tularemia and hepatitis, and has symptoms including jaundice, chills and fever. An important gene associated with Leptospirosis is TLR2 (Toll Like Receptor 2), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Glimepiride and Insulin Aspart have been mentioned in the context of this disorder. Affiliated tissues include kidney, lung and testes, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and cardiovascular system

CDC : 3 Leptospirosis is a bacterial disease that affects humans and animals. It is caused by bacteria of the genus Leptospira. In humans, it can cause a wide range of symptoms, some of which may be mistaken for other diseases. Some infected persons, however, may have no symptoms at all.

Wikipedia : 71 Leptospirosis is an infection caused by corkscrew-shaped bacteria called Leptospira. Signs and symptoms... more...

Related Diseases for Leptospirosis

Diseases related to Leptospirosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 376)
id Related Disease Score Top Affiliating Genes
1 tularemia 30.0 CD40LG IL10 TNF
2 hepatitis 30.0 IL10 IL6 TNF
3 intussusception 29.6 IL1B TNF
4 uveitis 29.3 CCL2 CD40LG TNF
5 calcinosis 28.9 CCL2 CD40LG CRP IL6 TNF
6 moyamoya disease 10.8
7 pyridoxal 5'-phosphate-dependent epilepsy 10.3 IL10 TNF
8 tubular renal disease-cardiomyopathy syndrome 10.3 IL10 TNF
9 acute infection of pinna 10.3 CRP F2
10 pulpitis 10.2 F2 IL10 TNF
11 low anorectal malformation 10.2 F2 IL10 TNF
12 conidiobolomycosis 10.2 CXCL8 IL10 TNF
13 myeloid proliferations related to down syndrome 10.2 CXCL8 TLR2
14 plantar wart 10.2 CXCL8 IL10 TNF
15 microcephaly 10.2 IL10 TLR2 TNF
16 abnormal retinal correspondence 10.2 IL10 TLR2 TNF
17 maturity-onset diabetes of the young 10.2 CD40LG IL10
18 demyelinating polyneuropathy 10.2 IL10 SLC12A1 SLC9A3
19 peripheral artery disease 10.2 IL10 TLR2 TNF
20 lagophthalmos 10.2 IL10 TNF
21 vps11-related autosomal recessive hypomyelinating leukodystrophy 10.2 IL6 TNF
22 handl syndrome 10.2 CXCL8 TLR2 TNF
23 cataract 10.2 CRP IL1B TNF
24 acquired polycythemia 10.2 CXCL8 IL10 TNF
25 dengue hemorrhagic fever 10.2 IL10 TLR2 TNF
26 pericholangitis 10.2 CRP TLR2 TNF
27 liver inflammatory pseudotumor 10.2 IL10 TLR2 TNF
28 tau syndrome 10.2 IL1B TNF
29 pyloric stenosis, infantile hypertrophic, 2 10.2 CRP IL1B TNF
30 transient tic disorder 10.2 IL10 IL6 TNF
31 urticaria 10.2 CRP IL1B TNF
32 cyclosporiasis 10.2 IL10 IL6 TNF
33 amyotrophic lateral sclerosis type 14 10.2 CXCL8 IL1B TNF
34 mesangial proliferative glomerulonephritis 10.2 CD40LG CXCL8
35 phlyctenulosis 10.2 IL10 IL6 TNF
36 patau syndrome 10.2 CRP IL1B TNF
37 appendiceal l-cell glucagon-like peptide producing tumor 10.2 CRP CXCL8 TLR2
38 primary ciliary dyskinesia 10.2 IL10 IL6 TNF
39 cryptococcosis 10.2 CD40LG IL10 TNF
40 astrocytoma 10.1 CD40LG IL10 TNF
41 coloboma of iris 10.1 CRP IL6
42 unilateral multicystic dysplastic kidney 10.1 CRP IL6 TNF
43 swine influenza 10.1 CRP IL6 TNF
44 orbital osteomyelitis 10.1 IL10 IL6 TNF
45 multiple mitochondrial dysfunctions syndrome 10.1 CRP IL10 IL6
46 glucose intolerance 10.1 CCL2 CXCL8 TNF
47 benign deep fibrous histiocytoma 10.1 CD40LG F2 TNF
48 nasal cavity cancer 10.1 CXCL8 IL1B TNF
49 joint disorders 10.1 CRP IL6 TNF
50 spotted fever 10.1 CD40LG TLR2 TNF

Comorbidity relations with Leptospirosis via Phenotypic Disease Network (PDN):


Acute Cystitis Acute Kidney Failure
Chronic Kidney Failure Deficiency Anemia
Familial Atrial Fibrillation Heart Disease

Graphical network of the top 20 diseases related to Leptospirosis:



Diseases related to Leptospirosis

Symptoms & Phenotypes for Leptospirosis

Symptoms:

12
  • jaundice
  • chills
  • fever
  • muscle pain
  • hepatomegaly

GenomeRNAi Phenotypes related to Leptospirosis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.77 IL1B TNF AQP1 CD40LG CXCL8 F2
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.77 TNF AQP1 CD40LG CXCL8 F2 IL10

MGI Mouse Phenotypes related to Leptospirosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.17 AQP1 CD40LG CRP F2 IL10 IL1B
2 homeostasis/metabolism MP:0005376 10.11 AQP1 CD40LG CRP F2 IL10 IL1B
3 hematopoietic system MP:0005397 10.1 TNF AQP1 CD40LG F2 IL10 IL1B
4 immune system MP:0005387 10.06 CCL2 CD40LG CRP F2 IL10 IL1B
5 integument MP:0010771 9.86 CD40LG F2 IL10 IL1B IL6 SLC12A1
6 renal/urinary system MP:0005367 9.63 CD40LG IL6 SLC12A1 SLC9A3 TLR2 AQP1
7 reproductive system MP:0005389 9.56 AQP1 CD40LG F2 IL10 IL6 SLC12A1
8 skeleton MP:0005390 9.28 AQP1 CD40LG F2 IL10 IL1B IL6

Drugs & Therapeutics for Leptospirosis

Drugs for Leptospirosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 174)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glimepiride Approved Phase 4 93479-97-1 3476
2
Insulin Aspart Approved Phase 4 116094-23-6 16132418
3
Insulin Glargine Approved Phase 4 160337-95-1
4
Metformin Approved Phase 4 657-24-9 14219 4091
5
Zinc Approved Phase 4 7440-66-6 32051 23994
6
Citalopram Approved Phase 4 59729-33-8 2771
7
Fluoxetine Approved, Vet_approved Phase 4 54910-89-3 3386
8
Norepinephrine Approved Phase 4 51-41-2 439260
9 Anti-Arrhythmia Agents Phase 4
10 Biphasic Insulins Phase 4
11 Hypoglycemic Agents Phase 4
12 Immunosuppressive Agents Phase 4,Phase 2
13 insulin Phase 4
14 Insulin aspart, insulin aspart protamine drug combination 30:70 Phase 4
15 Insulin degludec, insulin aspart drug combination Phase 4
16 Insulin, Globin Zinc Phase 4
17 Insulin, Isophane Phase 4
18 Insulin, Long-Acting Phase 4
19 Protamines Phase 4
20 Autonomic Agents Phase 4,Phase 2,Phase 3,Phase 1
21 Neurotransmitter Agents Phase 4
22 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1
23 Antidepressive Agents Phase 4
24 Antidepressive Agents, Second-Generation Phase 4
25 Antiparkinson Agents Phase 4
26 Cholinergic Agents Phase 4
27 Cholinergic Antagonists Phase 4
28 Cytochrome P-450 CYP2D6 Inhibitors Phase 4
29 Cytochrome P-450 Enzyme Inhibitors Phase 4
30 Fingolimod Hydrochloride Phase 4
31 Muscarinic Antagonists Phase 4
32 Neurotransmitter Uptake Inhibitors Phase 4
33 Parasympatholytics Phase 4
34 Psychotropic Drugs Phase 4
35
Serotonin Phase 4 50-67-9 5202
36 Serotonin Agents Phase 4
37 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4
38 Serotonin Uptake Inhibitors Phase 4
39 Venlafaxine Hydrochloride Phase 4
40
Dexamethasone Approved, Investigational, Vet_approved Phase 2, Phase 3,Phase 1 50-02-2 5743
41
Temozolomide Approved, Investigational Phase 3 85622-93-1 5394
42
Apixaban Approved Phase 3 503612-47-3 10182969
43
Dalteparin Approved Phase 3 9041-08-1
44
Heparin Approved, Investigational Phase 3 9005-49-6 772 46507594
45
Benzocaine Approved Phase 3 1994-09-7, 94-09-7 2337
46 tannic acid Approved, Nutraceutical Phase 3
47 Alkylating Agents Phase 3
48 Antineoplastic Agents, Alkylating Phase 3
49 Anticoagulants Phase 3
50 Antithrombin III Phase 3

Interventional clinical trials:

(show top 50) (show all 76)
id Name Status NCT ID Phase
1 Plantar Fasciosis Treatment Using Coblation Completed NCT00189592 Phase 4
2 Efficacy and Safety of Biphasic Insulin Aspart 30 in Combination With Metformin in Type 2 Diabetes Completed NCT00619697 Phase 4
3 Combination of Antidepressants and Fingolimod Relapsing-remitting Multiple Sclerosis (RRMS) Patients With Depression Terminated NCT01436643 Phase 4
4 Phase 3 Randomized, Double-blind, Controlled Study of ICT-107 in Glioblastoma Recruiting NCT02546102 Phase 3
5 Evaluation of the Use of Apixaban in Prevnetion of Thromboembolic Disease in Patients With Myeloma Trated With iMiDs Recruiting NCT02066454 Phase 3
6 A Study Investigating the Safety and Efficacy of Lampalizumab Intravitreal Injections in Patients With Geographic Atrophy Secondary to Age-Related Macular Degeneration (SPECTRI) Recruiting NCT02247531 Phase 3
7 Long-Term Safety of Lampalizumab Intravitreal (ITV) Injections in Participants With Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration (OMASPECT) Recruiting NCT02745119 Phase 3
8 Tralokinumab Monotherapy for Moderate to Severe Atopic Dermatitis - ECZTRA 1 (ECZema TRAlokinumab Trial no. 1) Recruiting NCT03131648 Phase 3
9 Effect of TTFields (150 kHz) in Non-small Cell Lung Cancer (NSCLC) Patients With 1-10 Brain Metastases Following Radiosurgery (METIS) Recruiting NCT02831959 Phase 3
10 Efficacy Evaluation of TheraSphere Following Failed First Line Chemotherapy in Metastatic Colorectal Cancer Recruiting NCT01483027 Phase 3
11 Desmopressin and Dexamethasone Adjunctive Treatment for Leptospirosis Terminated NCT00592566 Phase 2, Phase 3
12 Efficacy and Safety Study in the Treatment of Chronic Diabetic Foot Ulcers Terminated NCT00387101 Phase 3
13 Investigation of Cogane (PYM50028) in Early-stage Parkinson's Disease (CONFIDENT-PD) Completed NCT01060878 Phase 2
14 Effectiveness of MORAb-003 in Women With Ovarian Cancer Who Have Relapsed After Platinum-Based Chemotherapy Completed NCT00318370 Phase 2
15 The CareFUL Prevention Trial Completed NCT00803608 Phase 2
16 Repeat-Dose of Forodesine Hydrochloride (BCX-1777) Infusion in Patients With Advanced T-Cell Leukemia Completed NCT00095381 Phase 2
17 An Open Label Extension Study of the Efficacy of MORAb-003 Completed NCT01018563 Phase 2
18 A Study Comparing Eribulin Mesylate and Ixabepilone in Causing or Exacerbating Neuropathy in Patients With Advanced Breast Cancer Completed NCT00879086 Phase 2
19 Trial of CPX-351 in Adult Patients With First Relapse Acute Myeloid Leukemia (AML) Completed NCT00822094 Phase 2
20 Topical PluroGel PN for the Treatment of Mildly Infected Diabetic Foot Ulcers Completed NCT02119754 Phase 2
21 Topical PluroGel N for the Treatment of Mildly Infected Diabetic Foot Ulcers Completed NCT02091596 Phase 2
22 The Effect of Platelet-rich Plasma in Subjects With Androgenetic Alopecia Recruiting NCT03048461 Phase 2
23 A Study to Assess the Efficacy and Safety of Farletuzumab (MORAb 003) in Combination With Carboplatin Plus Paclitaxel or Carboplatin Plus Pegylated Liposomal Doxorubicin (PLD) in Subjects With Low CA125 Platinum-Sensitive Ovarian Cancer Recruiting NCT02289950 Phase 2
24 Open-Label, Dose Escalation Study of PRTX-100 in Adults With Persistent/Chronic Immune Thrombocytopenia Recruiting NCT02401061 Phase 1, Phase 2
25 A Study of AG-348 in Adult Patients With Pyruvate Kinase Deficiency Active, not recruiting NCT02476916 Phase 2
26 Safety Study of Farletuzumab, Carboplatin and Pegylated Liposomal Doxorubicin (PLD) to Treat Platinum-sensitive Ovarian Cancer Completed NCT01004380 Phase 1
27 Safety Study of the Proteasome Inhibitor PR-171 (Carfilzomib for Injection) in Patients With Hematological Malignancies Completed NCT00150462 Phase 1
28 Safety Study of AZD5672 in Renally Impaired Subjects Completed NCT00715702 Phase 1
29 A Study of MORAb-009 in Subjects With Pancreatic Cancer, Mesothelioma, or Certain Types of Ovarian or Lung Cancer Completed NCT00325494 Phase 1
30 Immune Tests in Blood Samples From Children With ASD Unknown status NCT02168868
31 Multicenter Trial of Daily Chlorhexidine Bathing to Reduce Nosocomial Infections Unknown status NCT00502476
32 Concentration and Activity of Lapatinib in Vestibular Schwannomas Unknown status NCT00863122 Early Phase 1
33 Shared Online Health Records for Patient Safety and Care Unknown status NCT00251875
34 The Sero-Prevalence and Genetic Study for the Infectious Diseases and Metabolic Syndrome in Solomon Islands Completed NCT01080989
35 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases In Patients With Persistent Fever in Cambodia, Nepal, Democratic Republic of the Congo and Sudan (NIDIAG-Fever) Completed NCT01766830
36 Non-interventional Observational Study on WHO-5 Questionnaire Application in Parkinson's Disease Completed NCT00752388
37 Efficacy of Pantoprazole in Patients Older Than 12 Years With Reflux Associated Sleep Disorders (PULS) Completed NCT00562094
38 Prospective, Study for the Use of Palivizumab (Synagis) in High Risk Children in Germany Completed NCT01155193
39 Caregivers' and Physicians' Treatment Preference in Parkinson Patients Treated With Neupro® Requiring Caregiver Support Completed NCT01330290
40 Fluid Challenges in Intensive Care Completed NCT01787071
41 Intraoperative Three Dimensional Fluoroscopy Compared to Standard Fluoroscopy for the Assessment of Reduction of Ankle Fractures With Syndesmosis Disruption Completed NCT00556010
42 BIOmarkers of Dyspnea IN Emergency Room Completed NCT01227317
43 Observational Non-interventional Study (Anwendungsbeobachtung) With Telmisartan in High-risk Hypertensives Completed NCT00539487
44 Quality of Life in Daxas-treated Patients Older Than 18 Years With Severe COPD Completed NCT01285180
45 Study for a Rational Management of Appendicitis in Children Completed NCT01067937
46 The Effect of Foot Orthoses on the Braking Response Time Completed NCT02354066
47 Three Injections of EUFLEXXA (Sodium Hyaluronate) for Treatment of Chronic Shoulder Pain Associated With Osteoarthritis (OA) Completed NCT00969501
48 Chemotherapeutic Agents in Brain/Breast Completed NCT00795678
49 Dabigatran Etexilate for Stroke Prevention in Patients With Atrial Fibrillation and Mild to Moderate Renal Impairment Completed NCT01721837
50 Persistence, Adherence, Quality of Life, and Treatment Satisfaction With Avonex® PEN™. Completed NCT01405872

Search NIH Clinical Center for Leptospirosis

Cochrane evidence based reviews: leptospirosis

Genetic Tests for Leptospirosis

Anatomical Context for Leptospirosis

MalaCards organs/tissues related to Leptospirosis:

39
Kidney, Lung, Testes, Skin, T Cells, Heart, Liver

Publications for Leptospirosis

Articles related to Leptospirosis:

(show top 50) (show all 696)
id Title Authors Year
1
A systematic review of leptospirosis on dogs, pigs, and horses in Latin America. ( 27909915 )
2017
2
New trends in human and animal leptospirosis in Croatia, 2009-2014. ( 28063871 )
2017
3
Varied presentations of leptospirosis: experience from a tertiary care hospital in north India. ( 28092222 )
2017
4
Molecular detection of leptospirosis and melioidosis co-infection: A case report. ( 28330585 )
2017
5
Low-dose norfloxacin and ciprofloxacin therapy worsen leptospirosis in hamster. ( 27894961 )
2017
6
Comparing antibiotic treatment for leptospirosis using network meta-analysis: a tutorial. ( 28056834 )
2017
7
Leptospirosis-Associated Severe Pulmonary Hemorrhagic Syndrome with Lower Back Pain as an Initial Symptom. ( 27881835 )
2016
8
Risk factors for leptospirosis seropositivity in slaughterhouse workers in western Kenya. ( 27913579 )
2016
9
BVA concern about press reports on leptospirosis vaccine. ( 27422909 )
2016
10
Severe leptospirosis and pancreatitis; A case series from a leptospirosis outbreak in Anuradhapura district, Sri Lanka. ( 27821124 )
2016
11
Antibodies for Rickettsia spp. in patients with negative serology for dengue virus, leptospirosis, and meningococcal disease in municipalities of SALo Paulo State, Brazil. ( 27812650 )
2016
12
Serological surveillance of Leptospirosis in Italy: twoa89year national data (2010a892011). ( 27393874 )
2016
13
The Epidemiology and Characteristics of Q fever and Co-infections with Scrub Typhus, Murine Typhus or Leptospirosis in Taiwan: A Nationwide Database Study. ( 27966835 )
2016
14
LEPTOSPIROSIS INCIDENCE AND MORTALITY IN MALAYSIA. ( 27405126 )
2016
15
Marked increase in leptospirosis infections in humans and dogs in the Netherlands, 2014. ( 27168584 )
2016
16
Serological survey of leptospirosis among different groups in western Iran. ( 27589994 )
2016
17
Saccharomyces boulardii improves humoral immune response to DNA vaccines against leptospirosis. ( 28008823 )
2016
18
Genetic diversity of Leptospira in northwestern Colombia: first report of Leptospira santarosai as a recognised leptospirosis agent. ( 27982303 )
2016
19
Correction: Epidemiology of Leptospirosis in Africa: A Systematic Review of a Neglected Zoonosis and a Paradigm for 'One Health' in Africa. ( 26967907 )
2016
20
Underestimation of Leptospirosis Incidence in the French West Indies. ( 27128631 )
2016
21
Cytokine and Chemokine Expression in Kidneys during Chronic Leptospirosis in Reservoir and Susceptible Animal Models. ( 27219334 )
2016
22
Human Leptospirosis in Malaysia: Reviewing the Challenges After 8 Decades (1925-2012). ( 27044535 )
2016
23
Leptospirosis: A Public Health Story Encircling the Globe. ( 27161412 )
2016
24
Leptospirosis Presenting with Rapidly Progressing Acute Renal Failure and Conjugated Hyperbilirubinemia: A Case Report. ( 27506868 )
2016
25
Fatal leptospirosis and chikungunya co-infection: Do not forget leptospirosis during chikungunya outbreaks. ( 27413690 )
2016
26
Molecular diagnostics for human leptospirosis. ( 27537829 )
2016
27
Characterization of leptospirosis among dogs in Oregon, 2007-2011. ( 27031417 )
2016
28
Blood collection by gingival puncture on hamsters reduces animal number in leptospirosis virulence tests. ( 27410254 )
2016
29
Hemorrhagic, Hemostatic, and Thromboelastometric Disorders in 35 Dogs with a Clinical Diagnosis of Leptospirosis: A Prospective Study. ( 27911985 )
2016
30
Snowflakes in August: Leptospirosis Hemorrhagic Pneumonitis. ( 27542609 )
2016
31
Fever, thrombocytopenia, and AKI-A profile of malaria, dengue, and leptospirosis with renal failure in a South Indian tertiary-care hospital. ( 27509584 )
2016
32
Redefining Gold Standard Testing for Diagnosing Leptospirosis: Further Evidence from a Well-Characterized, Flood-Related Outbreak in Sri Lanka. ( 27402521 )
2016
33
Cerebellar ataxia due to Leptospirosis- a case report. ( 27955629 )
2016
34
Clinical and laboratory associations of severity in a Sri Lankan cohort of patients with serologically confirmed leptospirosis: a prospective study. ( 27076513 )
2016
35
Seroprevalence of and risk factors for leptospirosis in the City of Manaus, State of Amazonas, Brazil. ( 27812660 )
2016
36
A Rapid In-Clinic Test Detects Acute Leptospirosis in Dogs with High Sensitivity and Specificity. ( 27110562 )
2016
37
Caprine leptospirosis: Hematobiochemical and urinalyses studies. ( 27057122 )
2016
38
TLR2 agonist Pam3CSK4 alleviates the pathology of leptospirosis in hamster. ( 27620721 )
2016
39
Cathelicidin Insufficiency in Patients with Fatal Leptospirosis. ( 27812211 )
2016
40
Leptospirosis in sub-Himalayan region: A neglected entity. ( 27514970 )
2016
41
Arrhythmias in leptospirosis-associated acute kidney injury: a case series. ( 28041768 )
2016
42
A case-control study of epidemiological factors associated with leptospirosis in South Gujarat region. ( 27531691 )
2016
43
Hemodiafiltration Decreases Serum Levels of Inflammatory Mediators in Severe Leptospirosis: A Prospective Study. ( 27487001 )
2016
44
Chronic kidney disease of uncertain etiology in Sri Lanka: Are leptospirosis and Hantaviral infection likely causes? ( 27142134 )
2016
45
Work Environment-Related Risk Factors for Leptospirosis among Plantation Workers in Tropical Countries: Evidence from Malaysia. ( 27393322 )
2016
46
Effect of temperature, relative humidity and rainfall on dengue fever and leptospirosis infections in Manila, the Philippines. ( 27608858 )
2016
47
Paediatric leptospirosis: A population based case-control study from Chennai, India. ( 27080780 )
2016
48
Pediatric Fulminant Leptospirosis Complicated by Pericardial Tamponade, Macrophage Activation Syndrome and Sclerosing Cholangitis. ( 27761292 )
2016
49
A study of leptospirosis in South African horses and associated risk factors. ( 27836047 )
2016
50
Atypical leptospirosis: an overlooked cause of aseptic meningitis. ( 26964740 )
2016

Variations for Leptospirosis

Expression for Leptospirosis

Search GEO for disease gene expression data for Leptospirosis.

Pathways for Leptospirosis

Pathways related to Leptospirosis according to GeneCards Suite gene sharing:

(show top 50) (show all 63)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.01 CCL2 CD40LG CRP CXCL8 IL10 IL1B
2
Show member pathways
13.65 CCL2 CD40LG CXCL8 F2 IL10 IL1B
3
Show member pathways
13.51 CCL2 CXCL8 F2 IL10 IL1B IL6
4
Show member pathways
13.44 CCL2 CD40LG CXCL8 IL10 IL1B IL6
5
Show member pathways
13.36 CCL2 CD40LG CXCL8 IL10 IL1B IL6
6
Show member pathways
13.31 CCL2 CD40LG CXCL8 IL10 IL1B IL6
7
Show member pathways
13.03 CCL2 CXCL8 IL1B IL6 TLR1 TLR2
8
Show member pathways
12.95 CCL2 CXCL8 IL10 IL1B IL6 TLR1
9
Show member pathways
12.9 CD40LG CXCL8 IL10 IL1B IL6 TNF
10
Show member pathways
12.84 CCL2 CXCL8 IL1B IL6 TLR2 TNF
11
Show member pathways
12.76 CD40LG IL1B IL6 TLR1 TLR2 TNF
12
Show member pathways
12.66 CCL2 F2 IL10 IL1B IL6 TNF
13
Show member pathways
12.64 CD40LG IL1B TLR1 TLR2 TNF
14
Show member pathways
12.63 IL10 IL1B IL6 TLR2 TNF
15 12.53 CCL2 CD40LG IL10 IL1B TLR1 TLR2
16
Show member pathways
12.49 CD40LG IL10 IL1B IL6 TNF
17
Show member pathways
12.41 CCL2 CRP F2 IL1B IL6 TNF
18
Show member pathways
12.41 CCL2 CXCL8 IL1B IL6 TLR2 TNF
19
Show member pathways
12.34 CXCL8 IL6 TLR1 TLR2 TNF
20
Show member pathways
12.32 CD40LG IL10 IL1B TLR2 TNF
21 12.31 IL10 IL1B IL6 TLR1 TLR2 TNF
22
Show member pathways
12.3 CXCL8 IL1B IL6 TNF
23
Show member pathways
12.24 CXCL8 IL10 IL1B IL6 TNF
24
Show member pathways
12.24 CXCL8 IL1B IL6 TLR1 TLR2 TNF
25 12.23 CXCL8 IL10 IL1B IL6 SLC9A3 TNF
26 12.22 IL6 TLR1 TLR2 TNF
27 12.02 CCL2 IL1B IL6 TNF
28 12.01 AQP1 CCL2 CXCL8 IL1B IL6 TNF
29
Show member pathways
12 IL1B TLR1 TLR2
30 12 CCL2 CXCL8 IL1B IL6 TNF
31
Show member pathways
11.99 IL1B IL6 TLR1 TLR2
32 11.97 IL10 IL6 TNF
33 11.97 CCL2 CXCL8 IL10 IL1B IL6 TNF
34 11.95 CD40LG CXCL8 IL1B TNF
35 11.93 CXCL8 IL1B IL6
36
Show member pathways
11.91 IL10 IL1B IL6 TLR1 TLR2 TNF
37 11.89 IL1B IL6 TNF
38 11.87 CXCL8 IL10 IL1B IL6 TNF
39 11.85 IL10 IL1B IL6 TNF
40 11.83 CXCL8 IL1B IL6
41 11.83 CXCL8 IL10 IL1B IL6 TLR2 TNF
42 11.81 CD40LG IL10 IL6 TLR2 TNF
43 11.8 IL10 IL1B TNF
44
Show member pathways
11.77 CD40LG CXCL8 TNF
45 11.75 CCL2 CXCL8 IL1B IL6 TLR2 TNF
46 11.72 CCL2 CXCL8 IL1B IL6 TNF
47
Show member pathways
11.71 CD40LG CXCL8 IL1B IL6 TNF
48 11.62 CCL2 IL1B TLR2 TNF
49 11.62 CXCL8 IL1B IL6 TLR2 TNF
50 11.53 IL1B IL6 TNF

GO Terms for Leptospirosis

Cellular components related to Leptospirosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.81 CCL2 CD40LG CRP CXCL8 F2 IL10
2 external side of plasma membrane GO:0009897 9.56 CD40LG F2 IL6 TNF
3 extracellular space GO:0005615 9.28 CCL2 CD40LG CRP CXCL8 F2 IL10
4 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 8.96 TLR1 TLR2

Biological processes related to Leptospirosis according to GeneCards Suite gene sharing:

(show top 50) (show all 60)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.99 CRP IL1B IL6 TLR2 TNF
2 platelet activation GO:0030168 9.9 CD40LG F2 IL6
3 cellular response to tumor necrosis factor GO:0071356 9.9 CCL2 CXCL8 IL6
4 positive regulation of angiogenesis GO:0045766 9.89 AQP1 CXCL8 IL1B
5 response to lipopolysaccharide GO:0032496 9.88 CCL2 IL10 IL1B IL6 TLR2
6 response to wounding GO:0009611 9.87 CCL2 F2 IL6
7 cellular response to interleukin-1 GO:0071347 9.87 CCL2 CXCL8 IL6
8 cellular response to organic cyclic compound GO:0071407 9.86 CCL2 IL1B TNF
9 response to insulin GO:0032868 9.85 IL10 IL6 TLR2
10 neutrophil chemotaxis GO:0030593 9.85 CCL2 CXCL8 IL1B
11 positive regulation of T cell proliferation GO:0042102 9.85 CD40LG IL1B IL6
12 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.85 IL10 IL1B IL6 TNF
13 humoral immune response GO:0006959 9.83 CCL2 IL6 TNF
14 positive regulation of nitric oxide biosynthetic process GO:0045429 9.81 IL1B IL6 TNF
15 response to glucocorticoid GO:0051384 9.81 CCL2 IL10 IL6 TNF
16 cellular response to estradiol stimulus GO:0071392 9.8 CCL2 IL10 IL6
17 defense response to Gram-positive bacterium GO:0050830 9.8 CRP IL6 TLR2 TNF
18 acute-phase response GO:0006953 9.77 CRP F2 IL6
19 cellular response to dexamethasone stimulus GO:0071549 9.76 AQP1 CCL2 IL6
20 protein kinase B signaling GO:0043491 9.75 CCL2 IL1B TNF
21 negative regulation of lipid catabolic process GO:0050995 9.73 IL1B TNF
22 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.73 IL10 TNF
23 positive regulation of interleukin-8 production GO:0032757 9.73 IL1B TLR2 TNF
24 negative regulation of growth of symbiont in host GO:0044130 9.72 IL10 TNF
25 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.72 IL1B TNF
26 cell activation GO:0001775 9.72 TLR1 TLR2
27 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.72 CD40LG IL1B IL6 TLR2 TNF
28 cellular response to hepatocyte growth factor stimulus GO:0035729 9.71 IL10 IL6
29 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.71 CCL2 TLR2
30 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.71 IL1B TNF
31 positive regulation of NF-kappaB import into nucleus GO:0042346 9.71 IL1B TLR2 TNF
32 cellular homeostasis GO:0019725 9.7 AQP1 CCL2
33 PERK-mediated unfolded protein response GO:0036499 9.7 CCL2 CXCL8
34 regulation of cytokine secretion GO:0050707 9.7 TLR1 TLR2
35 positive regulation of chemokine biosynthetic process GO:0045080 9.7 IL1B TNF
36 positive regulation of chemokine production GO:0032722 9.7 IL6 TLR2 TNF
37 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.68 IL1B TLR1
38 endothelial cell apoptotic process GO:0072577 9.68 IL10 TNF
39 regulation of establishment of endothelial barrier GO:1903140 9.68 IL1B TNF
40 negative regulation of cytokine secretion involved in immune response GO:0002740 9.67 IL10 TNF
41 positive regulation of interleukin-6 production GO:0032755 9.67 IL1B IL6 TLR2 TNF
42 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.66 IL6 TNF
43 regulation of vascular endothelial growth factor production GO:0010574 9.65 CCL2 IL6
44 positive regulation of fever generation GO:0031622 9.65 IL1B TNF
45 regulation of immunoglobulin secretion GO:0051023 9.65 CD40LG TNF
46 cellular response to lipopolysaccharide GO:0071222 9.65 CCL2 CXCL8 IL10 IL6 TNF
47 sequestering of triglyceride GO:0030730 9.64 IL1B TNF
48 response to molecule of bacterial origin GO:0002237 9.63 CXCL8 IL10 TLR2
49 receptor biosynthetic process GO:0032800 9.62 IL10 TNF
50 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.62 IL1B TNF

Molecular functions related to Leptospirosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.17 CCL2 CD40LG CXCL8 IL10 IL1B IL6
2 lipopeptide binding GO:0071723 8.96 TLR1 TLR2

Sources for Leptospirosis

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