MCID: LPT001
MIFTS: 62

Leptospirosis malady

Categories: Rare diseases, Infectious diseases, Skin diseases

Aliases & Classifications for Leptospirosis

About this section
Sources:
2CDC, 11Disease Ontology, 13DISEASES, 30ICD10, 31ICD10 via Orphanet, 32ICD9CM, 39MeSH, 40MESH via Orphanet, 45NCIt, 48NIH Rare Diseases, 50Novoseek, 54Orphanet, 62SNOMED-CT, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Leptospirosis:

Name: Leptospirosis 11 48 54 50 2 39 13 68
Weil Disease 48 39 68
Hemorrhagic Jaundice 48 68
Stuttgart Disease 48 68
Fort Bragg Fever 11 68
Canicola Fever 48 68
Leptospirosis Icterohaemorrhagica 11
Equine Infectious Anemia 68
Icterohemorrhagic Fever 48
Rat Catcher's Yellows 11
 
Spirochetal Jaundice 11
Canine Leptospirosis 68
Swineherd's Disease 48
Cane-Cutter Fever 48
Nanukayami Fever 11
Rice-Field Fever 48
Weil's Disease 11
Swamp Fever 48
Nanukayami 68
Mud Fever 48

Characteristics:

Orphanet epidemiological data:

54
leptospirosis:
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: All ages; Age of death: normal life expectancy

Classifications:



External Ids:

Disease Ontology11 DOID:2297
ICD1030 A27, A27.0, A27.9
ICD9CM32 100, 100.0, 100.9
NCIt45 C84825
Orphanet54 ORPHA509
ICD10 via Orphanet31 A27.8, A27.9, A27.0
MESH via Orphanet40 D007922
UMLS via Orphanet69 C0023364

Summaries for Leptospirosis

About this section
Disease Ontology:11 A primary bacterial infectious disease that involves systemic infection, has material basis in Leptospira, which is transmitted by contact with water, food, or soil containing urine from the infected animals. The infection has symptom jaundice, has symptom chills, has symptom fever, has symptom muscle pain, and has symptom hepatomegaly.

MalaCards based summary: Leptospirosis, also known as weil disease, is related to tularemia and hepatitis, and has symptoms including jaundice, chills and fever. An important gene associated with Leptospirosis is TLR2 (Toll Like Receptor 2), and among its related pathways are Calcineurin-regulated NFAT-dependent transcription in lymphocytes and Innate Lymphoid Cell Differentiation Pathways. Affiliated tissues include kidney, lung and testes, and related mouse phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and renal/urinary system.

CDC:2 Leptospirosis is a bacterial disease that affects humans and animals. It is caused by bacteria of the genus Leptospira. In humans, it can cause a wide range of symptoms, some of which may be mistaken for other diseases. Some infected persons, however, may have no symptoms at all.

Wikipedia:71 Leptospirosis is an infection caused by corkscrew-shaped bacteria called Leptospira. Signs and symptoms... more...

Related Diseases for Leptospirosis

About this section

Diseases related to Leptospirosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 376)
idRelated DiseaseScoreTop Affiliating Genes
1tularemia30.0CD40LG, IL10, TNF
2hepatitis30.0IL10, IL6, TNF
3intussusception29.6IL1B, TNF
4uveitis29.3CCL2, CD40LG, TNF
5calcinosis28.9CCL2, CD40LG, CRP, IL6, TNF
6moyamoya disease10.8
7pyridoxal 5'-phosphate-dependent epilepsy10.3IL10, TNF
8tubular renal disease-cardiomyopathy syndrome10.3IL10, TNF
9acute infection of pinna10.3CRP, F2
10pulpitis10.2F2, IL10, TNF
11low anorectal malformation10.2F2, IL10, TNF
12conidiobolomycosis10.2CXCL8, IL10, TNF
13myeloid proliferations related to down syndrome10.2CXCL8, TLR2
14plantar wart10.2CXCL8, IL10, TNF
15microcephaly10.2IL10, TLR2, TNF
16abnormal retinal correspondence10.2IL10, TLR2, TNF
17maturity-onset diabetes of the young10.2CD40LG, IL10
18demyelinating polyneuropathy10.2IL10, SLC12A1, SLC9A3
19peripheral artery disease10.2IL10, TLR2, TNF
20lagophthalmos10.2IL10, TNF
21vps11-related autosomal recessive hypomyelinating leukodystrophy10.2IL6, TNF
22handl syndrome10.2CXCL8, TLR2, TNF
23cataract10.2CRP, IL1B, TNF
24acquired polycythemia10.2CXCL8, IL10, TNF
25dengue hemorrhagic fever10.2IL10, TLR2, TNF
26pericholangitis10.2CRP, TLR2, TNF
27liver inflammatory pseudotumor10.2IL10, TLR2, TNF
28tau syndrome10.2IL1B, TNF
29pyloric stenosis, infantile hypertrophic, 210.2CRP, IL1B, TNF
30transient tic disorder10.2IL10, IL6, TNF
31urticaria10.2CRP, IL1B, TNF
32cyclosporiasis10.2IL10, IL6, TNF
33amyotrophic lateral sclerosis type 1410.2CXCL8, IL1B, TNF
34mesangial proliferative glomerulonephritis10.2CD40LG, CXCL8
35phlyctenulosis10.2IL10, IL6, TNF
36patau syndrome10.2CRP, IL1B, TNF
37appendiceal l-cell glucagon-like peptide producing tumor10.2CRP, CXCL8, TLR2
38primary ciliary dyskinesia10.2IL10, IL6, TNF
39cryptococcosis10.2CD40LG, IL10, TNF
40astrocytoma10.1CD40LG, IL10, TNF
41coloboma of iris10.1CRP, IL6
42unilateral multicystic dysplastic kidney10.1CRP, IL6, TNF
43swine influenza10.1CRP, IL6, TNF
44orbital osteomyelitis10.1IL10, IL6, TNF
45multiple mitochondrial dysfunctions syndrome10.1CRP, IL10, IL6
46glucose intolerance10.1CCL2, CXCL8, TNF
47benign deep fibrous histiocytoma10.1CD40LG, F2, TNF
48nasal cavity cancer10.1CXCL8, IL1B, TNF
49joint disorders10.1CRP, IL6, TNF
50spotted fever10.1CD40LG, TLR2, TNF

Comorbidity relations with Leptospirosis via Phenotypic Disease Network (PDN):


Deficiency AnemiaAcute Kidney Failure
Chronic Kidney FailureFamilial Atrial Fibrillation
Heart DiseaseAcute Cystitis

Graphical network of the top 20 diseases related to Leptospirosis:



Diseases related to leptospirosis

Symptoms & Phenotypes for Leptospirosis

About this section

Symptoms:

 11 (show all 5)
  • jaundice
  • chills
  • fever
  • muscle pain
  • hepatomegaly

GenomeRNAi Phenotypes related to Leptospirosis according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00250-A-14.9AQP1, CD40LG, CXCL8, F2, IL10, IL1B

MGI Mouse Phenotypes related to Leptospirosis according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.7AQP1, CD40LG, IL6, SLC12A1, SLC9A3, TLR2
2MP:00107718.6CD40LG, F2, IL10, IL1B, IL6, SLC12A1
3MP:00053898.0AQP1, CD40LG, F2, IL10, IL6, SLC12A1
4MP:00053907.7AQP1, CD40LG, F2, IL10, IL1B, IL6
5MP:00053977.3AQP1, CD40LG, F2, IL10, IL1B, IL6
6MP:00053877.1CCL2, CD40LG, CRP, F2, IL10, IL1B
7MP:00053857.0AQP1, CD40LG, CRP, F2, IL10, IL1B
8MP:00053767.0AQP1, CD40LG, CRP, F2, IL10, IL1B

Drugs & Therapeutics for Leptospirosis

About this section

Drugs for Leptospirosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 174)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
MetforminapprovedPhase 41803657-24-914219, 4091
Synonyms:
1,1-Dimethyl biguanide
1,1-Dimethylbiguanide
3-(diaminomethylidene)-1,1-dimethylguanidine
657-24-9
AC1L1HE4
AKOS000121065
Apo-Metformin
BIDD:GT0697
BPBio1_000009
BRD-K79602928-003-04-1
BSPBio_000007
BSPBio_002314
C07151
C4H11N5
CAS-1115-70-4
CCRIS 9321
CHEBI:6801
CHEMBL1431
CID4091
D04966
DB00331
DMGG
Diabetosan
Diabex
Dimethylbiguanid
Dimethylbiguanide
Dimethylbiguanidine
Dimethyldiguanide
Dimethylguanylguanidine
EINECS 211-517-8
Fluamine
Flumamine
Fortamet
Gen-Metformin
Glifage
Gliguanid
Glucophage
Glucophage XR
Glumetza
Glycon
HMS2089D19
HSCI1_000295
Haurymelin
Haurymellin
Islotin
KBio2_002310
KBio2_004878
KBio2_007446
KBio3_002790
KBioGR_002310
 
KBioSS_002312
LA-6023
LS-43899
Melbin
Metformin
Metformin (USAN/INN)
Metformin HCL
Metformin [USAN:INN:BAN]
Metformina
Metformina [DCIT]
Metformina [Spanish]
Metformine
Metformine [INN-French]
Metformine pamoate
Metforminum
Metforminum [INN-Latin]
Metiguanide
MolPort-002-929-560
MolPort-004-288-389
MolPort-005-767-418
Mylan-Metformin
N,N-Dimethylbiguanide
N,N-Dimethyldiguanide
N,N-Dimethylimidodicarbonimidic diamide
N,N-dimethylimidodicarbonimidic diamide
N1,N1-Dimethylbiguanide
NCGC00016564-01
NCGC00016564-02
NCGC00016564-03
NNDG
Novo-Metformin
Nu-Metformin
PMS-Metformin
Prestwick0_000004
Prestwick1_000004
Prestwick2_000004
Prestwick3_000004
Ran-Metformin
Ratio-Metformin
Riomet
S2483_Selleck
SPBio_001928
STK011633
Sandoz Metformin
Siofor
T5895664
Teva-Metformin
UNII-9100L32L2N
ZINC12859773
cMAP_000016
metformin
metformin hydrochloride
2
Insulin GlargineapprovedPhase 4528160337-95-1
Synonyms:
 
Insulin Glargine (rDNA origin)
Insulin glargine recombinant
3
GlimepirideapprovedPhase 423493479-97-13476
Synonyms:
1-((p-(2-(3-Ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)ethyl)phenyl)sulfonyl)-3-(trans-4-methylcyclohexyl)urea
1-{[4-(2-{[(3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)carbonyl]amino}ethyl)phenyl]sulfonyl}-3-(trans-4-methylcyclohexyl)urea
3-ethyl-4-methyl-N-[2-(4-{[(trans-4-methylcyclohexyl)carbamoyl]sulfamoyl}phenyl)ethyl]-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide
3-ethyl-4-methyl-n-(4-(n-((1r,4r)-4-methylcyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-oxo-2,5-dihydro
4-ethyl-3-methyl-N-[2-[4-[(4-methylcyclohexyl)carbamoylsulfamoyl]phenyl]ethyl]-5-oxo-2H-pyrrole-1-carboxamide
64598P
93479-97-1
AB00513874
AC-476
AC1L1G0T
Amarel
Amaryl
Amaryl (TN)
Amaryl, Glista OD, Glimepiride
Avaglim
BPBio1_000751
BRD-K34776109-001-03-4
BRD-K42693031-001-01-8
BRN 5365754
BSPBio_000681
Bio-0049
C07669
C24H34N4O5S
CAS-93479-97-1
CCRIS 7083
CHEBI:5383
CHEMBL1481
CID3476
CPD000466368
D00593
DB00222
Endial
G2295_SIGMA
Glimepirid
Glimepirida
Glimepirida [Spanish]
Glimepiride (JAN/USP/INN)
Glimepiride [USAN:BAN:INN]
Glimepiridum
Glimepiridum [Latin]
 
Glimepride
Glimer
Glimépiride
Glymepirid
HMS1570C03
HMS2052L03
HMS2090K18
HOE 490
Hoe-490
I06-0029
I06-2285
LS-136752
MLS000759495
MLS001076674
MLS001401419
MolPort-003-847-587
MolPort-003-987-461
MolPort-005-941-721
NCGC00016960-01
NCGC00161404-01
NCGC00161404-02
NCGC00181757-01
Novo-glimepiride
Oprea1_382896
PMS-glimepiride
Prestwick0_000651
Prestwick1_000651
Prestwick2_000651
Prestwick3_000651
Ratio-glimepiride
Roname
S1344_Selleck
SAM001246710
SMR000466368
SPBio_002602
Sandoz glimepiride
Solosa
TL8005924
UNII-6KY687524K
ZINC00537791
glimepiride
4
ZincapprovedPhase 422967440-66-632051, 23994
Synonyms:
30Zn
Cinc
Zinc
Zinc ion
 
Zincum
Zink
Zn
Zn(ii)
Zn2+
5
Insulin AspartapprovedPhase 4442116094-23-616132418
Synonyms:
(AspB28)-human insulin
1024611-56-0
116094-23-6
139532-40-4
28(sup B)-L-Aspartic acid-insulin (human)
877034-90-7
AspB28-insulin (human)
Aspart
Aspart Insulin
Aspart insulin
B28-Asp-insulin
B28-Aspart-Insulin
INA-X 14
 
INA-X14
Insulin X14
Insulin aspart
Insulin aspart [USAN]
Insulin aspart protamine recombinant
Insulin aspart recombinant
Insulin, Asp(B28)
LS-185932
NovoLog
NovoMix 30
NovoRapid
NovoRapid 30 Mix
Novolog mix 70/30
UNII-D933668QVX
6
CitalopramapprovedPhase 451259729-33-82771
Synonyms:
1,3-Dihydro-1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-5-isobenzofurancarbonitrile
1,3-dihydro[3,4]benzofuran-5-carbonitrile
1-(3-(Dimethylamino)propyl)-1-(p-fluorophenyl)-5-phthalancarbonitrile
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-3H-2-benzofuran-5-carbonitrile
59729-33-8
AB00513896
AC-12214
AC1L1EFH
AE-641/00603021
Akarin
BPBio1_000929
BRD-A47598013-004-02-0
BSPBio_000843
Bonitrile
C07572
C20H21FN2O
CHEBI:3723
CHEMBL549
CID2771
CPD000465669
Celapram
Celexa
Celius
Ciazil
Cilift
Cipram
Cipramil
Ciprapine
Citabax
Citadur
Citadur (TN)
Citalec
Citalopram (USP/INN)
Citalopram Hydrobromide
Citalopram [Celexa]
Citalopram [INN:BAN]
Citalopram hydrobromide
Citalopramum
Citalopramum [INN-Latin]
 
Citol
Citopam
Citox
Citrol
Cytalopram
D07704
DB00215
Dalsan
EINECS 261-891-1
Elopram
HMS2090O09
HMS2093A14
Humorup
I01-0382
InChI=1/C20H21FN2O/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20/h4-9,12H,3,10-11,14H2,1-2H3
L001223
LS-84327
Lopac0_000258
Lu 10-171
Lu-10-171
MolPort-003-666-794
NCGC00015267-07
NCGC00025160-02
Nitalapram
Oropram
Pramcit
Prestwick3_000692
Recital
SAM002589960
ST069372
STL058639
Seropram
Talam
Talohexal
Temperax
UNII-0DHU5B8D6V
Vodelax
Zentius
Zetalo
[3H]Citalopram
citalopram
7
Fluoxetineapproved, vet_approvedPhase 423854910-89-33386
Synonyms:
(+) or (-)-N-Methyl-3-phenyl-3-((alpha,alpha,alpha-trifluoro-p-tolyl)oxy)propylamine
(+) or (-)-N-Methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine
(+-)-N-Methyl-3-phenyl-3-((alpha,alpha,alpha-trifluoro-P-tolyl)oxy)propylamine
(+-)-N-Methyl-3-phenyl-3-((alpha,alpha,alpha-trifluoro-p-tolyl)oxy)propylamine
(+-)-N-Methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine
(+/-)-Fluoxetine
(+/-)-N-Methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine
(+/-)-N-Methyl-3-p-(p-trifluoromethylphenoxy)-3-phenylpropylamine
(+/-)-N-Methyl-3-phenyl-3-[(alpha,alpha,alpha-trifluoro-p-tolyl)oxy]propylamine
(+/-)-N-Methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propylamine]
(+/-)-N-Methyl-gamma-[4-(trifluoromethyl)phenoxy]benzenepropanamine
3-(p-Trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine
52341-67-0
54910-89-3
57226-07-0
59333-67-4 (hydrochloride)
AB00053774
AC-14564
AC1L1FTH
AKOS003663021
Adofen
Animex-On
BPBio1_000354
BPBio1_000509
BRD-A31159102-001-01-9
BRD-A31159102-003-05-6
BSPBio_000461
BSPBio_003375
Bio-0787
Biomol-NT_000152
C17H18F3NO
CHEBI:5118
CHEMBL41
CID3386
D00326
DB00472
Deprex
DivK1c_006819
Eufor
Floxetine
Fluctin
Fluoxeren
Fluoxetin
Fluoxetina
Fluoxetina [INN-Spanish]
Fluoxetina [Spanish]
Fluoxetine (TN)
Fluoxetine (USAN/INN)
Fluoxetine Hcl
Fluoxetine Hydrochloride
Fluoxetine [USAN:INN:BAN]
Fluoxetinum
 
Fluoxetinum [INN-Latin]
Fluoxétine
Fluval
Fontex
Foxetin
HMS2090H14
KBio1_001763
KBio2_002159
KBio2_004727
KBio2_007295
KBio3_002595
KBioGR_001166
KBioSS_002159
L000931
LS-31040
Lilly-110140
Lopac0_000558
Methyl({3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl})amine
Methyl-[3-phenyl-3-(4-trifluoromethyl-phenoxy)-propyl]-amine
MolPort-001-683-482
N-Methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine
N-Methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine
N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine
N-methyl-3-phenyl-3-{[4-(trifluoromethyl)phenyl]oxy}propan-1-amine
NCGC00015428-10
NCGC00024879-03
NCGC00024879-04
NSC283480
Portal
Prestwick0_000511
Prestwick1_000511
Prestwick2_000511
Prestwick3_000511
Prozac
Prozac Weekly
Pulvules
Reconcile
Reneuron
SPBio_001815
SPBio_002382
STK734483
Sarafem
SpecPlus_000723
Spectrum2_001658
Spectrum3_001648
Spectrum4_000613
Spectrum5_001518
Spectrum_001679
TL8003595
UNII-01K63SUP8D
dl-3-(p-Trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine
fluoxetine
fluoxetine (Prozac)
nchembio.534-comp2
8
NorepinephrineapprovedPhase 469951-41-2439260
Synonyms:
(-)-(R)-Norepinephrine
(-)-Arterenol
(-)-Arterenol free base
(-)-NORADRENALINE
(-)-Noradrenaline
(-)-Norepinephrine
(-)-alpha-(Aminomethyl)protocatechuyl alcohol
(R)-(-)-Norepinephrine
(R)-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol
(R)-4-(2-amino-1-Hydroxyethyl)-1,2-benzenediol
(R)-Noradrenaline
(R)-Norepinephrine
1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)- (9CI)
4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol
4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol
4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol
4899-05-2
51-40-1 (l-tartrate (1:1))
51-41-2
66197-73-7
A7257_SIGMA
AC1L96ZT
ALBB-006229
Adrenor
Aktamin
Arterenol
BRN 4231961
BSPBio_002079
C00547
CHEBI:18357
CHEMBL1437
CID439260
D-(-)-Noradrenaline
D00076
D53D5E3A-2360-4CA9-8031-6C2CD4062FD5
DB00368
DivK1c_000230
EINECS 200-096-6
HMS1920B08
HMS2089E18
HMS2091J08
HMS500L12
IDI1_000230
KBio1_000230
KBio2_001489
KBio2_004057
KBio2_006625
KBio3_001579
KBioGR_000635
KBioSS_001489
L-2-Amino-1-(3,4-dihydroxyphenyl)ethanol
L-3,4-Dihydroxyphenylethanolamine
L-3,4-dihydroxyphenylethanolamine
L-Arterenol
L-Noradrenaline
L-Norepinephrine
L-alpha-(Aminomethyl)-3,4-dihydroxybenzyl alcohol
L-alpha-(aminomethyl)-3,4-dihydroxybenzyl alcohol
L-arterenol
L-noradrenaline
LS-42676
LT03330026
 
LT4
Levarterenol
Levarterenolo
Levarterenolo [DCIT]
Levoarterenol
Levonor
Levonoradrenaline
Levonorepinephrine
Levophed
NCGC00159406-02
NCGC00159406-03
NCGC00159406-04
NCGC00159406-05
NCGC00159406-06
NCGC00159406-07
NCGC00159406-09
NINDS_000230
Nor adrenalin
Nor adrenalin (TN)
Nor-Epirenan
Nor-adrenaline
Noradrenalin
Noradrenalina
Noradrenalina [Italian]
Noradrenaline
Noradrenaline (JP15)
Noradrenalinum
Norartrinal
Noreinefrina
Noreinefrina [INN-Spanish]
Norepinefrina
Norepinephrine
Norepinephrine (INN)
Norepinephrine Noradrenalin
Norepinephrine [INN:JAN]
Norepinephrine l-Tartrate (1:1)
Norepinephrinum
Norepinephrinum [INN-Latin]
Norepirenamine
PDSP1_001111
PDSP2_001095
SGCUT00123
SPBio_001048
SPECTRUM1500436
STK503776
Spectrum2_001064
Spectrum3_000520
Spectrum4_000078
Spectrum5_001068
Spectrum_001009
Sympathin E
UNII-X4W3ENH1CV
bmse000404
l-1-(3,4-Dihydroxyphenyl)-2-aminoethanol
l-2-Amino-1-(3,4-dihydroxyphenyl)ethanol
nchembio.284-comp2
nchembio.64-comp2
nchembio705-1
noradrenaline
norepinefrina
norepinephrine
norepinephrinum
to_000024
9Anti-Arrhythmia AgentsPhase 43093
10Peripheral Nervous System AgentsPhase 4, Phase 2, Phase 3, Phase 123689
11Neurotransmitter AgentsPhase 418340
12Autonomic AgentsPhase 4, Phase 2, Phase 3, Phase 110150
13ProtaminesPhase 4181
14Insulin degludec, insulin aspart drug combinationPhase 4248
15Insulin, Long-ActingPhase 4362
16Insulin aspart, insulin aspart protamine drug combination 30:70Phase 4106
17Immunosuppressive AgentsPhase 4, Phase 213086
18Hypoglycemic AgentsPhase 45896
19Biphasic InsulinsPhase 4156
20insulinPhase 44646
21Insulin, IsophanePhase 4252
22Insulin, Globin ZincPhase 44645
23ParasympatholyticsPhase 41085
24Serotonin and Noradrenaline Reuptake InhibitorsPhase 4457
25Neurotransmitter Uptake InhibitorsPhase 43521
26Venlafaxine HydrochloridePhase 4194
27Serotonin Uptake InhibitorsPhase 41587
28Serotonin AgentsPhase 43156
29Psychotropic DrugsPhase 46430
30
SerotoninPhase 4362750-67-95202
Synonyms:
3-(2-Aminoethyl)-1H-indol-5-ol
3-(2-Aminoethyl)indol-5-ol
3-(b-Aminoethyl)-5-hydroxyindole
5-HT
5-HTA
5-Hydroxy-3-(b-aminoethyl)indole
 
5-Hydroxy-tryptamine
5-Hydroxyltryptamine
5-Hydroxytriptamine
5-Hydroxytryptamine
Antemovis
DS substance
Enteramin
Enteramine
31Cholinergic AgentsPhase 43992
32Antidepressive AgentsPhase 42736
33Antidepressive Agents, Second-GenerationPhase 41311
34Muscarinic AntagonistsPhase 41166
35Cholinergic AntagonistsPhase 41706
36Antiparkinson AgentsPhase 41574
37Fingolimod HydrochloridePhase 488
38Cytochrome P-450 Enzyme InhibitorsPhase 43917
39Cytochrome P-450 CYP2D6 InhibitorsPhase 4727
40
Dexamethasoneapproved, investigational, vet_approvedPhase 2, Phase 3, Phase 1217150-02-25743
Synonyms:
(3H)-Dexamethasone
.delta.(sup 1)-9-.alpha.-Fluoro-16-.alpha.-methylcortisol
.gamma.corten
1-Dehydro-16.alpha.-methyl-9.alpha.-fluorohydrocortisone
1-Dehydro-16alpha -methyl-9alpha -fluorohydrocortisone
1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone
1-Dehydro-16α-methyl-9α-fluorohydrocortisone
137098-19-2
16-alpha-Methyl-9-alpha-fluoro-1-dehydrocortisol
16-alpha-Methyl-9-alpha-fluoro-delta(sup 1)-hydrocortisone
16-alpha-Methyl-9-alpha-fluoro-delta1-hydrocortisone
16-alpha-Methyl-9-alpha-fluoroprednisolone
16.alpha.-Methyl-9.alpha.-fluoro-1-dehydrocortisol
16.alpha.-Methyl-9.alpha.-fluoroprednisolone
16alpha -Methyl-9alpha -fluoro-1-dehydrocortisol
16alpha -Methyl-9alpha -fluoroprednisolone
16alpha-Methyl-9alpha-fluoro-1-dehydrocortisol
16alpha-Methyl-9alpha-fluoro-delta(sup 1)-hydrocortisone
16alpha-Methyl-9alpha-fluoroprednisolone
16α-Methyl-9α-fluoro-1-dehydrocortisol
23495-06-9
31375_FLUKA
46165_FLUKA
46165_RIEDEL
50-02-2
8054-59-9
9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
9-Fluoro-11alpha -methylpregna-1,4-diene-3,20-dione
9-Fluoro-16-methylprednisolone
9-alpha-Fluoro-16-alpha-methylprednisolone
9.alpha.-Fluoro-16.alpha.-methylprednisolone
906422-84-2
9A-FLUORO-16BETA-METHYLPREDNISOLONE
9alpha -Fluoro-16alpha -methylprednisolone
9alpha-Fluoro-16alpha-methylprednisolone
9alpha-fluoro-16alpha-methyl-Prednisolone
9α-Fluoro-16α-methylprednisolone
AC-11056
AC1L1L1H
AC1Q29DM
AI3-50934
Adexone
Aeroseb-D
Aeroseb-Dex
Aeroseb-dex
Ak Dex Oph Otic Soln 0.1%
Alcon Brand of Dexamethasone
Anaflogistico
Aphtasolon
Aphthasolone
Apo-dexamethasone
Auxiron
Azimycin (veterinary)
Azium
Azium (Veterinary)
Azium (veterinary)
BIDD:ER0494
BIDD:PXR0060
BRD-K38775274-001-02-3
BRD-K38775274-001-06-4
BSPBio_000995
Bisu DS
Bisu Ds
C15643
C22H29FO5
CCRIS 7067
CHEBI:41879
CHEMBL384467
CID5743
CPD-10549
CPD001227192
Calonat
Corson
Corsone
Cortisumman
D00292
D003907
D1756_SIGMA
D4902_SIGMA
D6645_SIGMA
D8893_SIGMA
D9184_SIGMA
DB01234
DEX
DEXA
DEXONE 0.5
DEXONE 0.75
DEXONE 1.5
DEXONE 4
DXM
DXMS
Decacort
Decacortin
Decaderm
Decadron
Decadron (TN)
Decadron Tablets, Elixir
Decadron, Dexamethasone
Decadron-LA
Decadron-La
Decagel
Decaject
Decaject L.A.
Decaject-L.A.
Decalix
Decameth
Decasone
Decaspray
Dectancyl
Dekacort
Delta1-9alpha-Fluoro-16alpha-methylcortisol
Deltafluorene
Dergramin
Deronil
Desadrene
Desametasone
Desametasone [DCIT]
Desametasone [Dcit]
Desamethasone
Desameton
Deseronil
Dex-Ide
Dex-ide
Dexa
Dexa Mamallet
Dexa mamallet
Dexa-Cortidelt
Dexa-Cortisyl
Dexa-Mamallet
Dexa-Scheroson
Dexa-Sine
Dexa-cortidelt
Dexa-cortisyl
Dexa-scheroson
Dexa-sine
Dexacen-4
Dexacidin
Dexacort
Dexacortal
Dexacortin
Dexadeltone
Dexafarma
Dexair
Dexalona
Dexaltin
Dexametasona
Dexametasona [INN-Spanish]
Dexametasone
 
Dexameth
Dexamethansone
Dexamethasone
Dexamethasone (JP15/USP/INN)
Dexamethasone Acetate
Dexamethasone Alcohol
Dexamethasone Base
Dexamethasone Intensol
Dexamethasone Sodium Phosphate
Dexamethasone [INN:BAN:JAN]
Dexamethasone alcohol
Dexamethasone base
Dexamethasone intensol
Dexamethasone-omega
Dexamethasonum
Dexamethasonum [INN-Latin]
Dexamethazone
Dexamonozon
Dexapolcort
Dexapos
Dexaprol
Dexason
Dexasone
Dexasone 0.5mg
Dexasone 0.75mg
Dexasone 4mg
Dexasporin
Dexinolon
Dexinoral
Dexone
Dexone 0.5
Dexone 0.75
Dexone 1.5
Dexone 4
Dexonium
Dexpak
Dextelan
Dezone
Dinormon
Dxms
ECR Brand of Dexamethasone
EINECS 200-003-9
FT-0080377
Fluormethylprednisolone
Fluormone
Fluorocort
Fortecortin
Foy Brand of Dexamethasone
Gammacorten
HL-dex
HMS1792A17
HMS1990A17
HMS2089N13
HSDB 3053
Hexadecadrol
Hexadrol
Hexadrol Elixir
Hexadrol Tablets
Hexadrol elixir
Hl-Dex
Hl-dex
I06-1196
ICN Brand of Dexamethasone
IontoDex
Isopto-Dex
Isopto-dex
LS-7300
Lokalison F
Lokalison f
Loverine
Luxazone
MK 125
MLS001055412
MLS001332507
MLS001332508
Maxidex
Maxidex Ont 0.1%
Maxidex Sus 0.1%
Maxitrol
Mediamethasone
Merck Brand of Dexamethasone
Merz Brand 1 of Dexamethasone
Merz Brand 2 of Dexamethasone
Methylfluorprednisolone
Mexidex
Millicorten
MolMap_000018
MolPort-003-846-433
Mymethasone
NCGC00091019-01
NCGC00091019-02
NCGC00091019-03
NCGC00091019-04
NCGC00091019-05
NCI60_003067
NSC 34521
NSC34521
Naquasone (veterinary)
Neomycin and polymyxin b sulfates and dexamethasone
Neomycin and polymyxin b sulphates and dexamethasone
OTO-104
Ocu-Trol
Ocu-trol
Oradexon
PHL-dexamethasone
PMS-dexamethasone
Pet Derm III
Pet Derm Iii
Pet derm III
Pet-Derm Iii
Pms Dexamethasone Elixir 0.5mg/5ml
Policort
Posurdex
Prednisolon F
Prednisolon f
Prednisolone F
Prednisolone f
Prodex
S1322_Selleck
SAM002548948
SGCUT00126
SK-Dexamethasone
SK-dexamethasone
SMP1_000092
SMR000857119
SMR001227192
ST50307091
Sandoz dexamethasone
Sk-Dexamethasone
Spectrum5_002019
Spoloven
Sunia Sol D
Sunia sol D
Superprednol
TL8003317
Tobradex
Tobramycin and dexamethasone
Tresaderm (veterinary)
Turbinaire
UNII-7S5I7G3JQL
Visumetazone
WLN: L E5 B666 OV KU MUTJ A1 BF CQ E1 FV1Q FQ G1
ZINC03875332
alpha -Fluoro-16-alpha -methylcortisol
delta(Sup 1)-9-alpha-Fluoro-16-alpha-methylcortisol
delta(sup 1)-9-alpha-Fluoro-16-alpha-methylcortisol
delta1-9alpha-Fluoro-16alpha-methylcortisol
dexamethasone
nchembio809-comp2
to_000038
41
ApixabanapprovedPhase 3154503612-47-310182969
Synonyms:
1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahyd
2p16
503612-47-3
AKOS005146204
Apixaban
Apixaban (JAN/USAN/INN)
BMS 562247-01
BMS-562247
BMS-562247-01
BMS-562247-01, Apixaban
 
CHEBI:49620
CHEMBL231779
CID10182969
D03213
DB07828
GG2
S1593_Selleck
UNII-3Z9Y7UWC1J
apixabanum
apixabán
ro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide
42
DalteparinapprovedPhase 33179041-08-1
Synonyms:
Daltepariininatrium
Dalteparin Sodyum
Dalteparin sodium
Dalteparin sodná sůl
Dalteparin-nátrium
Dalteparina sódica
 
Dalteparinnatrium
Dalteparino natrio druska
Dalteparinum Natricum
Dalteparyna sodowa
Daltéparine sodique
Heparin Fragment KABI 2165
Tedelparin
43
Heparinapproved, investigationalPhase 38489005-49-6772, 46507594
Synonyms:
101921-26-0
102-94-3
102785-31-9
104521-37-1
11078-24-3
11129-39-8
12656-11-0
2-o-sulfohexopyranuronosyl-(1->4)-2-deoxy-3-o-sulfo-2-(sulfoamino)hexopyranosyl-(1->4)-2-o-sulfohexopyranuronosyl-(1->4)-2-acetamido-2-deoxy-6-o-sulfohexopyranose
37324-73-5
6-[6-[6-[5-acetamido-4,6-dihydroxy-2-(sulfooxymethyl)oxan-3-yl]oxy-2-carboxy-4-hydroxy-5-sulfooxyoxan-3-yl]oxy-2-(hydroxymethyl)-5-(sulfoamino)-4-sulfooxyoxan-3-yl]oxy-3,4-dihydroxy-5-sulfooxyoxane-2-carboxylic acid
9041-08-1
9045-22-1
9075-96-1
913079-23-9
91449-79-5
AC1L19ZN
AC1L1ROY
ALFA 87-120
ALFA 87-163
ALFA 87-198
ALFA 87-81
ALFA 88-247
AR-1E4539
Allocinnamic acid
Ardeparin
Ardeparin sodium
Arteven
Bemiparin
Bemiparin sodium
CID772
CID8784
CY 216
Calciparine
Certoparin
Clexane
Clivarin
Clivarine
Cy 222
D006495
D017984
DB00407
DB01225
Dalteparin
Dalteparin sodium
Depo-Heparin
EINECS 232-681-7
EMT 966
EMT 967
EMT-966
EMT-967
EMT966
EMT967
Enoxaparin
Enoxaparin sodium
Enoxaparine
Eparina
Eparina [DCIT]
FR 860
Fluxum
Fragmin A
Fragmin B
Fragmin IV
Fraxiparin
H 2149
HSDB 3094
Hed-heparin
Hep Flush Kit in plastic container
Hep-Lock
Hep-Lock U/P
Hep-lock
Heparin
Heparin CY 216
Heparin Lock Flush
Heparin Lock Flush in plastic container
Heparin Lock Flush preservative free
Heparin Lock Flush preservative free in plastic container
Heparin Sodium
Heparin natrium
Heparin sodium
Heparin sodium 1,000 units and sodium chloride 0.9% in plastic container
Heparin sodium 1,000 units in dextrose 5% in plastic container
Heparin sodium 1,000 units in sodium chloride 0.9% in plastic container
Heparin sodium 10,000 units in dextrose 5%
Heparin sodium 10,000 units in dextrose 5% in plastic container
Heparin sodium 10,000 units in sodium chloride 0.45%
Heparin sodium 10,000 units in sodium chloride 0.9%
Heparin sodium 12,500 units in dextrose 5%
Heparin sodium 12,500 units in dextrose 5% in plastic container
Heparin sodium 12,500 units in sodium chloride 0.45% in plastic container
Heparin sodium 12,500 units in sodium chloride 0.9%
Heparin sodium 2,000 units and sodium chloride 0.9% in plastic container
Heparin sodium 2,000 units in dextrose 5% in plastic container
Heparin sodium 2,000 units in sodium chloride 0.9% in plastic container
Heparin sodium 20,000 units and dextrose 5% in plastic container
Heparin sodium 20,000 units in dextrose 5% in plastic container
Heparin sodium 25,000 units and dextrose 5% in plastic container
 
Heparin sodium 25,000 units in dextrose 5%
Heparin sodium 25,000 units in dextrose 5% in plastic container
Heparin sodium 25,000 units in sodium chloride 0.45% in plastic container
Heparin sodium 25,000 units in sodium chloride 0.9%
Heparin sodium 25,000 units in sodium chloride 0.9% in plastic container
Heparin sodium 5,000 units and sodium chloride 0.9% in plastic container
Heparin sodium 5,000 units in dextrose 5% in plastic container
Heparin sodium 5,000 units in sodium chloride 0.45%
Heparin sodium 5,000 units in sodium chloride 0.9%
Heparin sodium 5,000 units in sodium chloride 0.9% in plastic container
Heparin sodium in plastic container
Heparin sodium preservative Free
Heparin sulfate
Heparin sulphate
Heparin, Low Molecular Weight
Heparin, Low-Molecular-Weight
Heparin, sodium salt
Heparina
Heparina [INN-Spanish]
Heparinate
Heparine
Heparine [INN-French]
Heparinic acid
Heparinsodiumsalt
Heparinum
Heparinum [INN-Latin]
Heparinum natricum
Hepathrom
Hepflush-10
Inno-Hep
Innohep
Isocinnamic acid
KB 101
Kabi 2165
LHN 1
LMWH
Lioton 1000
Lipo-hepin
Liquaemin
Liquaemin Lock Flush
Liquaemin Sodium
Liquaemin sodium preservative free
Liquemin
Logiparin
Lovenox
Lovenox HP
Low Molecular Weight Heparin
Low molecular weight heparin
Low molecular weight heparin sodium
Low-Molecular-Weight Heparin
Minolteparin sodium
MolPort-003-760-257
Multiparin
NSC174025
Nadroparin
Nadroparine
Novoheparin
OP 386
OP 622
Octaparin
PK 10,169
PK-10,169
PK-10169
PK10,169
PK10169
Pabyrin
Panheprin
Parnaparin
Parnaparin sodium
Parvoparin
Pularin
Reviparin
Reviparin sodium
Ro 11
Sandoparin
Sodium acid heparin
Sodium heparin
Sodium heparinate
Subeparin
Sublingula
Thromboliquine
Tinzaparin
Tinzaparin sodium
Triofiban
UNII-12M44VTJ7B
UNII-3S182ET3UA
UNII-E47C0NF7LV
UNII-T2410KM04A
UNII-ZZ45AB24CA
Unfractionated heparin
Vetren
Vitrum AB
WY 90493RD
alpha-Heparin
cis-.beta.-Carboxystyrene
cis-Cinnamic acid
enoxaparin
heparin
44
Temozolomideapproved, investigationalPhase 371185622-93-15394
Synonyms:
3,4-Dihydro-3-methyl-4-oxoimidazo(5,1-d)-1,2,3,5-tetrazine-8-carboxamide
3,4-Dihydro-3-methyl-4-oxoimidazo(5,1-d)-as-tetrazine-8-carboxamide
3,4-dihydro-3-Methyl-4-oxoimidazo(5,1-D)-1,2,3,5-tetrazine-8-carboxamide
3,4-dihydro-3-Methyl-4-oxoimidazo(5,1-D)-as-tetrazine-8-carboxamide
3-Methyl-4-oxo-3,4-dihydroimidazo(5,1-D)(1,2,3,5)tetrazine-8-carboxamide
3-Methyl-4-oxo-3,4-dihydroimidazo(5,1-d)(1,2,3,5)tetrazine-8-carboxamide
3-Methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetraazine-8-carboxamide
3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide
3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide
8-Carbamoyl-3-methylimidazo(5,1-D)-1,2,3,5-tetrazin-4(3H)-one
8-Carbamoyl-3-methylimidazo(5,1-d)-1,2,3,5-tetrazin-4(3H)-one
85622-93-1
AC-758
AC1L1K9B
BIDD:GT0204
BRN 5547136
Bio-0147
C047246
C6H6N6O2
CCRG 81045
CCRG-81045
CCRIS 8996
CHEBI:153686
CHEMBL810
CID5394
CPD000466338
D06067
DB00853
Essex brand of temozolomide
HMS2051O12
HMS2090B08
I06-0149
I14-1943
LS-80558
M B 39831
M & B 39831
M&B 39831
M&B-39831
 
M-39831
MB 39831
MLS000759447
MLS001424028
MLS002701861
Methazolastone
NCGC00167429-01
NCGC00167429-02
NCI60_003316
NSC 362856
NSC-362856
NSC362856
SAM001246636
SMR000466338
STK623541
Sch 52365
Sch-52365
Schering brand of temozolomide
Schering-Plough brand of temozolomide
TL8005593
TMZ
TMZ-Bioshuttle
Temodal
Temodal (TN)
Temodar
Temozolamide
Temozolodida
Temozolodida [Spanish]
Temozolomid
Temozolomida
Temozolomide (JAN/USAN/INN)
Temozolomide [INN:BAN]
Temozolomidum
Temozolomidum [Latin]
Témozolomide
UNII-YF1K15M17Y
ZINC01482184
m & b 39831
temozolomide
45
BenzocaineapprovedPhase 320161994-09-7, 94-09-72337
Synonyms:
(p-(Ethoxycarbonyl)phenylamine
06952_FLUKA
112909_ALDRICH
112909_SIAL
1333-08-0
23239-88-5
23239-88-5 (hydrochloride)
4 Aminobenzoic Acid Ethyl Ester
4-(Ethoxycarbonyl)aniline
4-(Ethoxycarbonyl)phenylamine
4-14-00-01129 (Beilstein Handbook Reference)
4-Aminobenzoate
4-Aminobenzoic acid
4-Aminobenzoic acid ethyl ester
4-Aminobenzoic acid, ethyl ester
4-Carbethoxyaniline
4-amino-benzoic acid ethyl ester
4-aminobenzoic acid ethyl ester
71123-91-6
94-09-7
94-09-7 (Parent)
A0271
AB00051923
AC1L1DGC
AC1Q341A
AC1Q64JE
AE-562/40377256
AI3-02081
AKOS000119763
AR-1H9065
Acetate, Benzocaine
Aethoform
Aethylium paraminobenzoicum
Amben ethyl ester
Americaine
Anaesthan-syngala
Anaesthesin
Anaesthesinum
Anaesthin
Anestezin
Anestezin [Russian]
Anesthesin
Anesthesine
Anesthone
BB_SC-0019
BPBio1_001017
BRD-K75466013-001-05-2
BRN 0638434
BSPBio_000923
BSPBio_001908
Baby Anbesol
Bensokain
Benzoak
Benzocaina
Benzocaina [INN-Spanish]
Benzocaine
Benzocaine (USP/INN)
Benzocaine Acetate
Benzocaine Formate
Benzocaine Hydrobromide
Benzocaine Hydrochloride
Benzocaine Methanesulfonate
Benzocaine [INN:BAN]
Benzocainum
Benzocainum [INN-Latin]
Benzoic acid, 4-amino-, ethyl ester
Benzoic acid, 4-amino-, ethyl ester, hydrochloride
Benzoic acid, amino-, ethyl ester
Benzoic acid, p-amino-, ethyl ester
C07527
CAS-94-09-7
CHEBI:116735
CHEMBL278172
CID2337
Caswell No. 430A
Chloraseptic
D001566
D00552
DB01086
Dermoplast
Diet Ayds
DivK1c_000932
E1501_SIGMA
EINECS 202-303-5
EPA Pesticide Chemical Code 097001
ETHYL-P-AMINOBENZOATE
Ethoform
Ethoforme
Ethyl 4-aminobenzoate
Ethyl 4-aminobenzoate hydrochloride
Ethyl 4-aminobenzoic acid
Ethyl Aminobenzoate
Ethyl PABA
 
Ethyl aminobenzoate
Ethyl aminobenzoate (JP15)
Ethyl aminobenzoate (VAN)
Ethyl aminobenzoic acid
Ethyl p-Aminobenzoate
Ethyl p-Aminophenylcarboxylate
Ethyl p-aminobenzenecarboxylate
Ethyl p-aminobenzoate
Ethyl p-aminobenzoic acid
Ethyl p-aminophenylcarboxylate
Ethylester kyseliny p-aminobenzoove
Ethylester kyseliny p-aminobenzoove [Czech]
Ethylis aminobenzoas
Formate, Benzocaine
HMS1570O05
HMS1920G09
HMS2091M11
HMS502O14
HSDB 7225
Hurricaine
Hydrobromide, Benzocaine
Hydrochloride, Benzocaine
I05-0204
IDI1_000932
Identhesin
KBio1_000932
KBio2_000474
KBio2_003042
KBio2_005610
KBio3_001408
KBioGR_000658
KBioSS_000474
Keloform
LS-35847
MLS001331704
MLS002153970
Methanesulfonate, Benzocaine
MolPort-000-871-526
NCGC00016352-01
NCGC00094598-01
NCGC00094598-02
NINDS_000932
NSC 122792
NSC 41531
NSC41531
NSC4688
Norcain
Norcaine
Norcainum
Oprea1_750694
Oprea1_827402
Ora-jel
Orabase-B
Orthesin
Otocain
Outgro
Parathesin
Parathesin (TN)
Parathesine
Prestwick0_000712
Prestwick1_000712
Prestwick2_000712
Prestwick3_000712
Prestwick_991
SMR000059025
SPBio_000134
SPBio_002844
SPECTRUM1500139
STK043620
Slim Mint Gum
Solarcaine
Solu H
Spectrum2_000117
Spectrum3_000314
Spectrum4_000249
Spectrum5_000860
Spectrum_000074
Topcaine
UNII-U3RSY48JW5
WLN: ZR DVO2
ZINC12358719
benzocaine
ethylaminobenzoate-4
h-4-abz-oet
nchembio.182-comp4
p-(Ethoxycarbonyl)aniline
p-Aminobenzoate
p-Aminobenzoic acid
p-Aminobenzoic acid ethyl ester
p-Aminobenzoic acid, ethyl ester
p-Aminobenzoic ethyl ester
p-Carbethoxyaniline
p-Ethoxycarboxylic Aniline
p-Ethoxycarboxylic aniline
46tannic acidapproved, NutraceuticalPhase 32016
47ImmunoglobulinsPhase 3, Phase 16394
48Antibodies, MonoclonalPhase 3, Phase 14039
49Liver ExtractsPhase 34067
50Dexamethasone acetatePhase 2, Phase 3, Phase 121711177-87-3

Interventional clinical trials:

(show top 50)    (show all 76)
idNameStatusNCT IDPhase
1Plantar Fasciosis Treatment Using CoblationCompletedNCT00189592Phase 4
2Efficacy and Safety of Biphasic Insulin Aspart 30 in Combination With Metformin in Type 2 DiabetesCompletedNCT00619697Phase 4
3Combination of Antidepressants and Fingolimod Relapsing-remitting Multiple Sclerosis (RRMS) Patients With DepressionTerminatedNCT01436643Phase 4
4Phase 3 Randomized, Double-blind, Controlled Study of ICT-107 in GlioblastomaRecruitingNCT02546102Phase 3
5Evaluation of the Use of Apixaban in Prevnetion of Thromboembolic Disease in Patients With Myeloma Trated With iMiDsRecruitingNCT02066454Phase 3
6A Study Investigating the Safety and Efficacy of Lampalizumab Intravitreal Injections in Patients With Geographic Atrophy Secondary to Age-Related Macular Degeneration (SPECTRI)RecruitingNCT02247531Phase 3
7Long-Term Safety of Lampalizumab Intravitreal (ITV) Injections in Participants With Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration (OMASPECT)RecruitingNCT02745119Phase 3
8Tralokinumab Monotherapy for Moderate to Severe Atopic Dermatitis - ECZTRA 1 (ECZema TRAlokinumab Trial no. 1)RecruitingNCT03131648Phase 3
9Effect of TTFields (150 kHz) in Non-small Cell Lung Cancer (NSCLC) Patients With 1-10 Brain Metastases Following Radiosurgery (METIS)RecruitingNCT02831959Phase 3
10Efficacy Evaluation of TheraSphere Following Failed First Line Chemotherapy in Metastatic Colorectal CancerRecruitingNCT01483027Phase 3
11Desmopressin and Dexamethasone Adjunctive Treatment for LeptospirosisTerminatedNCT00592566Phase 2, Phase 3
12Efficacy and Safety Study in the Treatment of Chronic Diabetic Foot UlcersTerminatedNCT00387101Phase 3
13Investigation of Cogane (PYM50028) in Early-stage Parkinson's Disease (CONFIDENT-PD)CompletedNCT01060878Phase 2
14Effectiveness of MORAb-003 in Women With Ovarian Cancer Who Have Relapsed After Platinum-Based ChemotherapyCompletedNCT00318370Phase 2
15The CareFUL Prevention TrialCompletedNCT00803608Phase 2
16Repeat-Dose of Forodesine Hydrochloride (BCX-1777) Infusion in Patients With Advanced T-Cell LeukemiaCompletedNCT00095381Phase 2
17An Open Label Extension Study of the Efficacy of MORAb-003CompletedNCT01018563Phase 2
18A Study Comparing Eribulin Mesylate and Ixabepilone in Causing or Exacerbating Neuropathy in Patients With Advanced Breast CancerCompletedNCT00879086Phase 2
19Trial of CPX-351 in Adult Patients With First Relapse Acute Myeloid Leukemia (AML)CompletedNCT00822094Phase 2
20Topical PluroGel PN for the Treatment of Mildly Infected Diabetic Foot UlcersCompletedNCT02119754Phase 2
21Topical PluroGel N for the Treatment of Mildly Infected Diabetic Foot UlcersCompletedNCT02091596Phase 2
22The Effect of Platelet-rich Plasma in Subjects With Androgenetic AlopeciaRecruitingNCT03048461Phase 2
23A Study to Assess the Efficacy and Safety of Farletuzumab (MORAb 003) in Combination With Carboplatin Plus Paclitaxel or Carboplatin Plus Pegylated Liposomal Doxorubicin (PLD) in Subjects With Low CA125 Platinum-Sensitive Ovarian CancerRecruitingNCT02289950Phase 2
24Open-Label, Dose Escalation Study of PRTX-100 in Adults With Persistent/Chronic Immune ThrombocytopeniaRecruitingNCT02401061Phase 1, Phase 2
25A Study of AG-348 in Adult Patients With Pyruvate Kinase DeficiencyActive, not recruitingNCT02476916Phase 2
26Safety Study of Farletuzumab, Carboplatin and Pegylated Liposomal Doxorubicin (PLD) to Treat Platinum-sensitive Ovarian CancerCompletedNCT01004380Phase 1
27Safety Study of the Proteasome Inhibitor PR-171 (Carfilzomib for Injection) in Patients With Hematological MalignanciesCompletedNCT00150462Phase 1
28Safety Study of AZD5672 in Renally Impaired SubjectsCompletedNCT00715702Phase 1
29A Study of MORAb-009 in Subjects With Pancreatic Cancer, Mesothelioma, or Certain Types of Ovarian or Lung CancerCompletedNCT00325494Phase 1
30Immune Tests in Blood Samples From Children With ASDUnknown statusNCT02168868
31Multicenter Trial of Daily Chlorhexidine Bathing to Reduce Nosocomial InfectionsUnknown statusNCT00502476
32Concentration and Activity of Lapatinib in Vestibular SchwannomasUnknown statusNCT00863122Early Phase 1
33Shared Online Health Records for Patient Safety and CareUnknown statusNCT00251875
34The Sero-Prevalence and Genetic Study for the Infectious Diseases and Metabolic Syndrome in Solomon IslandsCompletedNCT01080989
35Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases In Patients With Persistent Fever in Cambodia, Nepal, Democratic Republic of the Congo and Sudan (NIDIAG-Fever)CompletedNCT01766830
36Non-interventional Observational Study on WHO-5 Questionnaire Application in Parkinson's DiseaseCompletedNCT00752388
37Efficacy of Pantoprazole in Patients Older Than 12 Years With Reflux Associated Sleep Disorders (PULS)CompletedNCT00562094
38Prospective, Study for the Use of Palivizumab (Synagis) in High Risk Children in GermanyCompletedNCT01155193
39Caregivers' and Physicians' Treatment Preference in Parkinson Patients Treated With Neupro® Requiring Caregiver SupportCompletedNCT01330290
40Fluid Challenges in Intensive CareCompletedNCT01787071
41Intraoperative Three Dimensional Fluoroscopy Compared to Standard Fluoroscopy for the Assessment of Reduction of Ankle Fractures With Syndesmosis DisruptionCompletedNCT00556010
42BIOmarkers of Dyspnea IN Emergency RoomCompletedNCT01227317
43Observational Non-interventional Study (Anwendungsbeobachtung) With Telmisartan in High-risk HypertensivesCompletedNCT00539487
44Quality of Life in Daxas-treated Patients Older Than 18 Years With Severe COPDCompletedNCT01285180
45Study for a Rational Management of Appendicitis in ChildrenCompletedNCT01067937
46The Effect of Foot Orthoses on the Braking Response TimeCompletedNCT02354066
47Three Injections of EUFLEXXA (Sodium Hyaluronate) for Treatment of Chronic Shoulder Pain Associated With Osteoarthritis (OA)CompletedNCT00969501
48Chemotherapeutic Agents in Brain/BreastCompletedNCT00795678
49Dabigatran Etexilate for Stroke Prevention in Patients With Atrial Fibrillation and Mild to Moderate Renal ImpairmentCompletedNCT01721837
50Persistence, Adherence, Quality of Life, and Treatment Satisfaction With Avonex® PEN™.CompletedNCT01405872

Search NIH Clinical Center for Leptospirosis


Cochrane evidence based reviews: weil disease

Genetic Tests for Leptospirosis

About this section

Anatomical Context for Leptospirosis

About this section

MalaCards organs/tissues related to Leptospirosis:

36
Kidney, Lung, Testes, Skin, T cells, Liver, Heart

Publications for Leptospirosis

About this section

Articles related to Leptospirosis:

(show top 50)    (show all 696)
idTitleAuthorsYear
1
A systematic review of leptospirosis on dogs, pigs, and horses in Latin America. (27909915)
2017
2
New trends in human and animal leptospirosis in Croatia, 2009-2014. (28063871)
2017
3
Varied presentations of leptospirosis: experience from a tertiary care hospital in north India. (28092222)
2017
4
Molecular detection of leptospirosis and melioidosis co-infection: A case report. (28330585)
2017
5
Low-dose norfloxacin and ciprofloxacin therapy worsen leptospirosis in hamster. (27894961)
2017
6
Comparing antibiotic treatment for leptospirosis using network meta-analysis: a tutorial. (28056834)
2017
7
Leptospirosis-Associated Severe Pulmonary Hemorrhagic Syndrome with Lower Back Pain as an Initial Symptom. (27881835)
2016
8
Risk factors for leptospirosis seropositivity in slaughterhouse workers in western Kenya. (27913579)
2016
9
BVA concern about press reports on leptospirosis vaccine. (27422909)
2016
10
Severe leptospirosis and pancreatitis; A case series from a leptospirosis outbreak in Anuradhapura district, Sri Lanka. (27821124)
2016
11
Antibodies for Rickettsia spp. in patients with negative serology for dengue virus, leptospirosis, and meningococcal disease in municipalities of SALo Paulo State, Brazil. (27812650)
2016
12
Serological surveillance of Leptospirosis in Italy: twoa89year national data (2010a892011). (27393874)
2016
13
The Epidemiology and Characteristics of Q fever and Co-infections with Scrub Typhus, Murine Typhus or Leptospirosis in Taiwan: A Nationwide Database Study. (27966835)
2016
14
LEPTOSPIROSIS INCIDENCE AND MORTALITY IN MALAYSIA. (27405126)
2016
15
Marked increase in leptospirosis infections in humans and dogs in the Netherlands, 2014. (27168584)
2016
16
Serological survey of leptospirosis among different groups in western Iran. (27589994)
2016
17
Saccharomyces boulardii improves humoral immune response to DNA vaccines against leptospirosis. (28008823)
2016
18
Genetic diversity of Leptospira in northwestern Colombia: first report of Leptospira santarosai as a recognised leptospirosis agent. (27982303)
2016
19
Correction: Epidemiology of Leptospirosis in Africa: A Systematic Review of a Neglected Zoonosis and a Paradigm for 'One Health' in Africa. (26967907)
2016
20
Underestimation of Leptospirosis Incidence in the French West Indies. (27128631)
2016
21
Cytokine and Chemokine Expression in Kidneys during Chronic Leptospirosis in Reservoir and Susceptible Animal Models. (27219334)
2016
22
Human Leptospirosis in Malaysia: Reviewing the Challenges After 8 Decades (1925-2012). (27044535)
2016
23
Leptospirosis: A Public Health Story Encircling the Globe. (27161412)
2016
24
Leptospirosis Presenting with Rapidly Progressing Acute Renal Failure and Conjugated Hyperbilirubinemia: A Case Report. (27506868)
2016
25
Fatal leptospirosis and chikungunya co-infection: Do not forget leptospirosis during chikungunya outbreaks. (27413690)
2016
26
Molecular diagnostics for human leptospirosis. (27537829)
2016
27
Characterization of leptospirosis among dogs in Oregon, 2007-2011. (27031417)
2016
28
Blood collection by gingival puncture on hamsters reduces animal number in leptospirosis virulence tests. (27410254)
2016
29
Hemorrhagic, Hemostatic, and Thromboelastometric Disorders in 35 Dogs with a Clinical Diagnosis of Leptospirosis: A Prospective Study. (27911985)
2016
30
Snowflakes in August: Leptospirosis Hemorrhagic Pneumonitis. (27542609)
2016
31
Fever, thrombocytopenia, and AKI-A profile of malaria, dengue, and leptospirosis with renal failure in a South Indian tertiary-care hospital. (27509584)
2016
32
Redefining Gold Standard Testing for Diagnosing Leptospirosis: Further Evidence from a Well-Characterized, Flood-Related Outbreak in Sri Lanka. (27402521)
2016
33
Cerebellar ataxia due to Leptospirosis- a case report. (27955629)
2016
34
Clinical and laboratory associations of severity in a Sri Lankan cohort of patients with serologically confirmed leptospirosis: a prospective study. (27076513)
2016
35
Seroprevalence of and risk factors for leptospirosis in the City of Manaus, State of Amazonas, Brazil. (27812660)
2016
36
A Rapid In-Clinic Test Detects Acute Leptospirosis in Dogs with High Sensitivity and Specificity. (27110562)
2016
37
Caprine leptospirosis: Hematobiochemical and urinalyses studies. (27057122)
2016
38
TLR2 agonist Pam3CSK4 alleviates the pathology of leptospirosis in hamster. (27620721)
2016
39
Cathelicidin Insufficiency in Patients with Fatal Leptospirosis. (27812211)
2016
40
Leptospirosis in sub-Himalayan region: A neglected entity. (27514970)
2016
41
Arrhythmias in leptospirosis-associated acute kidney injury: a case series. (28041768)
2016
42
A case-control study of epidemiological factors associated with leptospirosis in South Gujarat region. (27531691)
2016
43
Hemodiafiltration Decreases Serum Levels of Inflammatory Mediators in Severe Leptospirosis: A Prospective Study. (27487001)
2016
44
Chronic kidney disease of uncertain etiology in Sri Lanka: Are leptospirosis and Hantaviral infection likely causes? (27142134)
2016
45
Work Environment-Related Risk Factors for Leptospirosis among Plantation Workers in Tropical Countries: Evidence from Malaysia. (27393322)
2016
46
Effect of temperature, relative humidity and rainfall on dengue fever and leptospirosis infections in Manila, the Philippines. (27608858)
2016
47
Paediatric leptospirosis: A population based case-control study from Chennai, India. (27080780)
2016
48
Pediatric Fulminant Leptospirosis Complicated by Pericardial Tamponade, Macrophage Activation Syndrome and Sclerosing Cholangitis. (27761292)
2016
49
A study of leptospirosis in South African horses and associated risk factors. (27836047)
2016
50
Atypical leptospirosis: an overlooked cause of aseptic meningitis. (26964740)
2016

Variations for Leptospirosis

About this section

Expression for genes affiliated with Leptospirosis

About this section
Search GEO for disease gene expression data for Leptospirosis.

Pathways for genes affiliated with Leptospirosis

About this section

Pathways related to Leptospirosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 63)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.5CD40LG, CXCL8, TNF
29.5IL10, IL1B, TNF
39.4IL1B, IL6
4
Show member pathways
9.3IL1B, TLR1, TLR2
59.3IL10, IL6, TNF
69.2CCL2, IL1B, TNF
79.1IL1B, IL6, TNF
89.1IL1B, IL6, TNF
99.1IL1B, IL6, TNF
109.1IL1B, IL6, TNF
119.1CD40LG, CXCL8, IL1B, TNF
12
Show member pathways
9.1CXCL8, IL1B, IL6
139.1CXCL8, IL1B, IL6
149.0CCL2, IL1B, TLR2, TNF
15
Show member pathways
9.0CD40LG, IL10, IL1B, TLR2, TNF
169.0CCL2, CXCL8, IL6
178.9IL10, IL1B, IL6, TNF
188.9IL10, IL1B, IL6, TNF
198.9IL10, IL1B, IL6, TNF
208.9IL10, IL1B, IL6, TNF
218.8IL6, TLR1, TLR2, TNF
228.8CD40LG, IL10, IL6, TLR2, TNF
23
Show member pathways
8.8CXCL8, IL1B, IL6, TNF
24
Show member pathways
8.7CD40LG, IL1B, TLR1, TLR2, TNF
258.7CRP, CXCL8, IL6, TNF
26
Show member pathways
8.7IL1B, IL6, TLR1, TLR2
278.6CCL2, IL1B, IL6, TNF
28
Show member pathways
8.6IL10, IL1B, IL6, TLR2, TNF
29
Show member pathways
8.6CD40LG, IL10, IL1B, IL6, TNF
308.5CXCL8, IL1B, IL6, TLR2, TNF
31
Show member pathways
8.5CD40LG, CXCL8, IL1B, IL6, TNF
32
Show member pathways
8.5CXCL8, IL10, IL1B, IL6, TNF
338.5CXCL8, IL10, IL1B, IL6, TNF
348.5CCL2, F2, IL1B, TLR1, TLR2
35
Show member pathways
8.4CXCL8, IL6, TLR1, TLR2, TNF
368.2CCL2, CXCL8, IL1B, IL6, TNF
378.2CCL2, CXCL8, IL1B, IL6, TNF
388.2CXCL8, IL10, IL1B, IL6, TLR2, TNF
39
Show member pathways
8.2CD40LG, CXCL8, IL10, IL1B, IL6, TNF
408.1CXCL8, IL10, IL1B, IL6, SLC9A3, TNF
41
Show member pathways
8.1CD40LG, IL1B, IL6, TLR1, TLR2, TNF
42
Show member pathways
8.1IL10, IL1B, IL6, TLR1, TLR2, TNF
438.1IL10, IL1B, IL6, TLR1, TLR2, TNF
44
Show member pathways
8.0CCL2, F2, IL10, IL1B, IL6, TNF
45
Show member pathways
8.0CCL2, CXCL8, IL1B, IL6, TLR2, TNF
46
Show member pathways
8.0CCL2, CXCL8, IL1B, IL6, TLR2, TNF
478.0CCL2, CXCL8, IL1B, IL6, TLR2, TNF
48
Show member pathways
8.0CXCL8, IL1B, IL6, TLR1, TLR2, TNF
498.0CCL2, CXCL8, IL10, IL1B, IL6, TNF
508.0CCL2, CXCL8, IL10, IL1B, IL6, TNF

GO Terms for genes affiliated with Leptospirosis

About this section

Cellular components related to Leptospirosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.8CD40LG, F2, IL6, TNF
2Toll-like receptor 1-Toll-like receptor 2 protein complexGO:00353549.7TLR1, TLR2
3extracellular regionGO:00055767.7CCL2, CD40LG, CRP, CXCL8, F2, IL10
4extracellular spaceGO:00056156.8CCL2, CD40LG, CRP, CXCL8, F2, IL10

Biological processes related to Leptospirosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 60)
idNameGO IDScoreTop Affiliating Genes
1endothelial cell apoptotic processGO:007257710.7IL10, TNF
2negative regulation of cytokine secretion involved in immune responseGO:000274010.6IL10, TNF
3negative regulation of growth of symbiont in hostGO:004413010.6IL10, TNF
4regulation of immunoglobulin secretionGO:005102310.6CD40LG, TNF
5positive regulation of vascular smooth muscle cell proliferationGO:190470710.6IL10, TNF
6receptor biosynthetic processGO:003280010.6IL10, TNF
7negative regulation of lipid catabolic processGO:005099510.5IL1B, TNF
8positive regulation of calcidiol 1-monooxygenase activityGO:006055910.5IL1B, TNF
9positive regulation of chemokine biosynthetic processGO:004508010.5IL1B, TNF
10positive regulation of fever generationGO:003162210.5IL1B, TNF
11cell activationGO:000177510.5TLR1, TLR2
12cellular response to triacyl bacterial lipopeptideGO:007172710.5TLR1, TLR2
13detection of triacyl bacterial lipopeptideGO:004249510.5TLR1, TLR2
14positive regulation of membrane protein ectodomain proteolysisGO:005104410.5IL1B, TNF
15regulation of establishment of endothelial barrierGO:190314010.4IL1B, TNF
16regulation of I-kappaB kinase/NF-kappaB signalingGO:004312210.4IL1B, TNF
17positive regulation of nitric-oxide synthase biosynthetic processGO:005177010.4CCL2, TLR2
18regulation of cytokine secretionGO:005070710.4TLR1, TLR2
19cellular response to hepatocyte growth factor stimulusGO:003572910.3IL10, IL6
20epithelial cell proliferation involved in salivary gland morphogenesisGO:006066410.3IL6, TNF
21PERK-mediated unfolded protein responseGO:003649910.3CCL2, CXCL8
22positive regulation of interleukin-6 biosynthetic processGO:004541010.3IL1B, TLR1
23positive regulation of interleukin-8 productionGO:003275710.2IL1B, TLR2, TNF
24positive regulation of NF-kappaB import into nucleusGO:004234610.2IL1B, TLR2, TNF
25positive regulation of heterotypic cell-cell adhesionGO:003411610.2IL10, IL1B, TNF
26response to molecule of bacterial originGO:000223710.1CXCL8, IL10, TLR2
27positive regulation of chemokine productionGO:003272210.0IL6, TLR2, TNF
28cellular response to organic cyclic compoundGO:007140710.0CCL2, IL1B, TNF
29platelet activationGO:003016810.0CD40LG, F2, IL6
30regulation of vascular endothelial growth factor productionGO:001057410.0CCL2, IL6
31response to insulinGO:00328689.9IL10, IL6, TLR2
32protein kinase B signalingGO:00434919.9CCL2, IL1B, TNF
33cellular homeostasisGO:00197259.9AQP1, CCL2
34neutrophil chemotaxisGO:00305939.9CCL2, CXCL8, IL1B
35positive regulation of T cell proliferationGO:00421029.9CD40LG, IL1B, IL6
36acute-phase responseGO:00069539.9CRP, F2, IL6
37positive regulation of nitric oxide biosynthetic processGO:00454299.8IL1B, IL6, TNF
38negative regulation of lipid storageGO:00108889.8CRP, IL6, TNF
39cellular response to estradiol stimulusGO:00713929.8CCL2, IL10, IL6
40humoral immune responseGO:00069599.8CCL2, IL6, TNF
41sequestering of triglycerideGO:00307309.8IL1B, TNF
42lipopolysaccharide-mediated signaling pathwayGO:00316639.8CCL2, IL1B, TLR2, TNF
43cellular response to interleukin-1GO:00713479.7CCL2, CXCL8, IL6
44cellular response to tumor necrosis factorGO:00713569.7CCL2, CXCL8, IL6
45toll-like receptor TLR1:TLR2 signaling pathwayGO:00381239.7TLR1, TLR2
46defense response to Gram-positive bacteriumGO:00508309.6CRP, IL6, TLR2, TNF
47positive regulation of interleukin-6 productionGO:00327559.6IL1B, IL6, TLR2, TNF
48positive regulation of angiogenesisGO:00457669.6AQP1, CXCL8, IL1B
49positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.6IL10, IL1B, IL6, TNF
50response to glucocorticoidGO:00513849.4CCL2, IL10, IL6, TNF

Molecular functions related to Leptospirosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1lipopeptide bindingGO:00717239.7TLR1, TLR2
2cytokine activityGO:00051258.0CCL2, CD40LG, CXCL8, IL10, IL1B, IL6

Sources for Leptospirosis

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet