MCID: LPT001
MIFTS: 64

Leptospirosis

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Leptospirosis

MalaCards integrated aliases for Leptospirosis:

Name: Leptospirosis 12 72 49 55 51 3 41 14 69
Weil Disease 49 41 69
Hemorrhagic Jaundice 49 69
Stuttgart Disease 49 69
Fort Bragg Fever 12 69
Canicola Fever 49 69
Leptospirosis Icterohaemorrhagica 12
Equine Infectious Anemia 69
Icterohemorrhagic Fever 49
Rat Catcher's Yellows 12
Spirochetal Jaundice 12
Canine Leptospirosis 69
Swineherd's Disease 49
Cane-Cutter Fever 49
Nanukayami Fever 12
Rice-Field Fever 49
Weil's Disease 12
Weil Syndrome 72
Swamp Fever 49
Nanukayami 69
Mud Fever 49

Characteristics:

Orphanet epidemiological data:

55
leptospirosis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 55  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:2297
ICD10 32 A27 A27.0 A27.9
ICD9CM 34 100 100.0 100.9
NCIt 46 C84825
Orphanet 55 ORPHA509
MESH via Orphanet 42 D007922
UMLS via Orphanet 70 C0023364
ICD10 via Orphanet 33 A27.0 A27.8 A27.9

Summaries for Leptospirosis

Disease Ontology : 12 A primary bacterial infectious disease that involves systemic infection, has material basis in Leptospira, which is transmitted_by contact with water, food, or soil containing urine from the infected animals. The infection has symptom jaundice, has symptom chills, has symptom fever, has symptom muscle pain, and has symptom hepatomegaly.

MalaCards based summary : Leptospirosis, also known as weil disease, is related to acalculous cholecystitis and mononeuritis multiplex, and has symptoms including jaundice, chills and fever. An important gene associated with Leptospirosis is PIK3C2A (Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha), and among its related pathways/superpathways are PEDF Induced Signaling and TGF-Beta Pathway. The drugs Dexamethasone and Antiemetics have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and lung, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

CDC : 3 Leptospirosis is a bacterial disease that affects humans and animals. It is caused by bacteria of the genus Leptospira. In humans, it can cause a wide range of symptoms, some of which may be mistaken for other diseases. Some infected persons, however, may have no symptoms at all.

Wikipedia : 72 Leptospirosis is an infection caused by corkscrew-shaped bacteria called Leptospira. Signs and symptoms... more...

Related Diseases for Leptospirosis

Diseases related to Leptospirosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 422)
# Related Disease Score Top Affiliating Genes
1 acalculous cholecystitis 30.6 CD40LG CRP
2 mononeuritis multiplex 30.2 CD40LG CRP
3 panuveitis 29.9 CD40LG IL10 TNF
4 aseptic meningitis 29.8 CXCL8 IL10 IL1B TNF
5 melioidosis 29.7 IL10 IL6 TLR2 TNF
6 myocarditis 29.7 CD40LG IL6 TNF
7 hepatitis e 29.6 CD40LG F2 TNF
8 uveitis 29.6 CCL2 IL10 TNF
9 crimean-congo hemorrhagic fever 29.5 IL6 PIK3C2A TNF
10 acute pancreatitis 29.4 CRP CXCL8 IL10 IL6
11 end stage renal failure 29.4 CRP IL6 TNF
12 q fever 29.4 CD40LG IL10 IL1B TLR2 TNF
13 vasculitis 29.4 CCL2 CD40LG CRP TNF
14 avian influenza 29.4 CXCL8 IL6 TNF
15 scrub typhus 29.3 CD40LG CRP IL10 IL1B TLR2 TNF
16 intussusception 29.2 CD40LG CRP IL6
17 hemorrhagic fever 29.2 CD40LG F2 IL10 IL6 TNF
18 transverse myelitis 29.2 CXCL8 IL10 IL6 TNF
19 acute respiratory distress syndrome 29.2 CXCL8 IL1B IL6 TNF
20 respiratory failure 29.1 CRP CXCL8 IL10 PIK3C2A TNF
21 hemorrhagic fever with renal syndrome 29.1 CD40LG CRP IL10 IL6 TNF
22 chikungunya 29.0 CD40LG IL1B IL6 TNF
23 pericarditis 29.0 CRP IL1B IL6 TNF
24 brucellosis 29.0 CD40LG CRP CXCL8 IL10 IL6 TNF
25 gingivitis 28.9 CXCL8 IL1B IL6 TNF
26 toxoplasmosis 28.9 CD40LG IL10 IL1B IL6 TNF
27 adult respiratory distress syndrome 28.9 CXCL8 F2 IL10 IL6 TNF
28 kawasaki disease 28.7 CCL2 CRP IL10 IL6 TNF
29 cholangitis 28.7 CD40LG CRP F2 IL6 TNF
30 diabetes mellitus 28.6 CRP IL1B IL6 PIK3C2A TNF
31 central nervous system vasculitis 28.5 CD40LG CRP IL1B IL6 TNF
32 malaria 27.4 CCL2 CD40LG CRP CXCL8 IL10 IL1B
33 chlamydia 27.3 CD40LG CRP CXCL8 IL10 IL1B IL6
34 meningitis 27.2 CCL2 CD40LG CRP CXCL8 IL10 IL1B
35 pneumonia 26.4 CCL2 CD40LG CRP CXCL8 IL10 IL1B
36 peritonitis 26.1 AQP1 CCL2 CRP CXCL8 F2 IL10
37 dengue disease 11.3
38 leri-weill dyschondrosteosis 10.9
39 moyamoya disease 1 10.9
40 punctate inner choroidopathy 10.6 IL10 TNF
41 tropical endomyocardial fibrosis 10.6 IL10 TNF
42 microscopic polyangiitis 10.5 IL10 TNF
43 multifocal choroiditis 10.5 IL10 TNF
44 endomyocardial fibrosis 10.5 IL10 TNF
45 marburg hemorrhagic fever 10.5 F2 TNF
46 malignant otitis externa 10.5 CRP F2
47 transient hypogammaglobulinemia 10.5 IL10 TNF
48 anterior compartment syndrome 10.5 F2 PIK3C2A
49 choroiditis 10.5 IL10 TNF
50 neurosyphilis 10.5 IL10 TLR2

Comorbidity relations with Leptospirosis via Phenotypic Disease Network (PDN):


Acute Cystitis Acute Kidney Failure
Chronic Kidney Failure Deficiency Anemia
Familial Atrial Fibrillation Heart Disease

Graphical network of the top 20 diseases related to Leptospirosis:



Diseases related to Leptospirosis

Symptoms & Phenotypes for Leptospirosis

Symptoms:

12
  • jaundice
  • chills
  • fever
  • muscle pain
  • hepatomegaly

GenomeRNAi Phenotypes related to Leptospirosis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.77 CD40LG CXCL8 F2 IL10 IL1B TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.77 CD40LG CXCL8 F2 IL10 IL1B TNF
3 Decreased ionizing radiation sensitivity GR00232-A-1 9.5 CD40LG IL10 IL1B PIK3C2A SLC12A1 SLC9A3

MGI Mouse Phenotypes related to Leptospirosis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.23 AQP1 CD40LG CRP F2 IL10 IL1B
2 homeostasis/metabolism MP:0005376 10.18 AQP1 CD40LG CRP F2 IL10 IL1B
3 hematopoietic system MP:0005397 10.13 AQP1 CD40LG F2 IL10 IL1B IL6
4 immune system MP:0005387 10.11 IL10 IL1B IL6 PIK3C2A SLC12A1 TLR2
5 integument MP:0010771 9.92 IL6 SLC12A1 TLR2 TNF IL10 IL1B
6 nervous system MP:0003631 9.91 AQP1 CD40LG F2 IL10 IL1B IL6
7 renal/urinary system MP:0005367 9.7 AQP1 CD40LG IL6 PIK3C2A SLC12A1 SLC9A3
8 reproductive system MP:0005389 9.56 AQP1 CD40LG F2 IL10 IL6 SLC12A1
9 skeleton MP:0005390 9.28 AQP1 CD40LG F2 IL10 IL1B IL6

Drugs & Therapeutics for Leptospirosis

Drugs for Leptospirosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 2, Phase 3 50-02-2 5743
2 Antiemetics Phase 2, Phase 3
3 Anti-Inflammatory Agents Phase 2, Phase 3
4 Antineoplastic Agents, Hormonal Phase 2, Phase 3
5 Arginine Vasopressin Phase 2, Phase 3
6 Autonomic Agents Phase 2, Phase 3
7 BB 1101 Phase 2, Phase 3
8 Coagulants Phase 2, Phase 3
9 Deamino Arginine Vasopressin Phase 2, Phase 3
10 Dexamethasone acetate Phase 2, Phase 3 1177-87-3
11 Gastrointestinal Agents Phase 2, Phase 3
12 glucocorticoids Phase 2, Phase 3
13 Hemostatics Phase 2, Phase 3
14 HIV Protease Inhibitors Phase 2, Phase 3
15 Hormone Antagonists Phase 2, Phase 3
16 Hormones Phase 2, Phase 3
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
18 Natriuretic Agents Phase 2, Phase 3
19 Peripheral Nervous System Agents Phase 2, Phase 3
20
protease inhibitors Phase 2, Phase 3
21 Vasopressins Phase 2, Phase 3
22 arginine Nutraceutical Phase 2, Phase 3
23
Albendazole Approved, Vet_approved 54965-21-8 2082
24
Ivermectin Approved, Investigational, Vet_approved 70288-86-7 46936176 6474909
25
Mebendazole Approved, Vet_approved 31431-39-7 4030
26
Ethanol Approved 64-17-5 702
27
Doxycycline Approved, Investigational, Vet_approved Early Phase 1 564-25-0 54671203
28
Tetracycline Approved, Vet_approved Early Phase 1 60-54-8 5353990
29 Anti-Bacterial Agents Early Phase 1
30 Antibiotics, Antitubercular
31 Anti-Infective Agents Early Phase 1
32 Antibodies
33 Immunoglobulins
34 Antimalarials Early Phase 1
35 Antiparasitic Agents Early Phase 1
36 Antiprotozoal Agents Early Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Desmopressin and Dexamethasone Adjunctive Treatment for Leptospirosis Terminated NCT00592566 Phase 2, Phase 3 Dexamethasone, desmopressin
2 Study of Decreasing Kinetics of the Leptospiremia During Antibiotic Treatment of Leptospirosis in Martinique Unknown status NCT02000635
3 French West Indies Leptospirosis Study Unknown status NCT01607047
4 The Sero-Prevalence and Genetic Study for the Infectious Diseases and Metabolic Syndrome in Solomon Islands Completed NCT01080989
5 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases In Patients With Persistent Fever in Cambodia, Nepal, Democratic Republic of the Congo and Sudan (NIDIAG-Fever) Completed NCT01766830
6 Scrub Typhus RDT Study Recruiting NCT03269266
7 Immune Response After Leptospirosis Infection Not yet recruiting NCT02898519
8 Oral Doxycycline for the Prevention of Syphilis in Men Who Have Sex With Men Not yet recruiting NCT02864550 Early Phase 1 Doxycycline

Search NIH Clinical Center for Leptospirosis

Cochrane evidence based reviews: leptospirosis

Genetic Tests for Leptospirosis

Anatomical Context for Leptospirosis

MalaCards organs/tissues related to Leptospirosis:

38
Kidney, Testes, Lung, T Cells, Heart, Eye, Liver

Publications for Leptospirosis

Articles related to Leptospirosis:

(show top 50) (show all 740)
# Title Authors Year
1
Major epidemiological factors associated with leptospirosis in Malaysia. ( 29217379 )
2018
2
Unusual ocular clinical manifestation of leptospirosis. ( 29398239 )
2018
3
Report of a case of leptospirosis: the importance of asking the patient about workplace factors. ( 29437314 )
2018
4
Leptospirosis presenting as haemolytic uraemic syndrome: a case report. ( 29378539 )
2018
5
Leptospirosis in Caspian Sea littoral, Gilan Province, Iran. ( 29407848 )
2018
6
Chimeras could help in the fight against leptospirosis. ( 29350615 )
2018
7
Recent findings related to immune responses against leptospirosis and novel strategies to prevent infection. ( 29452258 )
2018
8
Seroprevalence and risk factor analysis of human leptospirosis in distinct climatic regions of Pakistan. ( 29407239 )
2018
9
Pathogen-specific leptospiral proteins in urine of patients with febrile illness aids in differential diagnosis of leptospirosis from dengue. ( 29332210 )
2018
10
Prevalence of Bovine Viral Diarrhoea Virus (BVDV), Bovine Herpes Virus 1 (BHV 1), Leptospirosis and Neosporosis, and associated risk factors in 161 Irish beef herds. ( 29304782 )
2018
11
Molecular detection of leptospirosis and melioidosis co-infection: A case report. ( 28330585 )
2017
12
Human leptospirosis in the Federal District, Brazil, 2011-2015: eco-epidemiological characterization. ( 29340454 )
2017
13
Rapid, actionable diagnosis of urban epidemic leptospirosis using a pathogenic Leptospira lipL32-based real-time PCR assay. ( 28915243 )
2017
14
Efficacy of a new recrystallized enrofloxacin hydrochloride-dihydrate against leptospirosis in a hamster model. ( 28874381 )
2017
15
Severe leptospirosis in Morocco: comparative data from the Amazonian area. ( 28875288 )
2017
16
Bovine leptospirosis in urban and peri-urban dairy farming in low-income countries: a "One Health" issue? ( 29233193 )
2017
17
Leptospirosis presenting as acute acalculous cholecystitis. ( 29152269 )
2017
18
Human leptospirosis in Seychelles: A prospective study confirms the heavy burden of the disease but suggests that rats are not the main reservoir. ( 28846678 )
2017
19
Leptospirosis Renal Disease: Emerging Culprit of Chronic Kidney Disease Unknown Etiology. ( 28926845 )
2017
20
Comparing antibiotic treatment for leptospirosis using network meta-analysis: a tutorial. ( 28056834 )
2017
21
A Case of Kawasaki Disease With Concomitant Leptospirosis. ( 28804750 )
2017
22
Increased levels of soluble forms of E-selectin and ICAM-1 adhesion molecules during human leptospirosis. ( 28686648 )
2017
23
Leptospirosis on captive wild animals in Latin America. ( 28804053 )
2017
24
Platelet dysfunction contributes to bleeding complications in patients with probable leptospirosis. ( 28934202 )
2017
25
Correction: Underestimation of Leptospirosis Incidence in the French West Indies. ( 29211733 )
2017
26
Cardiac Magnetic Resonance of Myocardial Involvement in Leptospirosis. ( 29326780 )
2017
27
Evaluation of clinical, laboratory, imaging findings and outcome in 99 dogs with leptospirosis. ( 28804909 )
2017
28
Multi-organ failure, weeks after being exposed to murky water - rule out leptospirosis. ( 28808510 )
2017
29
Correction: Cathelicidin Insufficiency in Patients with Fatal Leptospirosis. ( 28950012 )
2017
30
A systematic review of leptospirosis on dogs, pigs, and horses in Latin America. ( 27909915 )
2017
31
Epidemiological and clinical features of leptospirosis in a highly endemic area over three time periods. ( 28857412 )
2017
32
Isolation of Leptospira kmetyi from residential areas of patients with leptospirosis in Kelantan, Malaysia. ( 29277333 )
2017
33
A Case of Leptospirosis-Associated Severe Pulmonary Hemorrhagic Syndrome Successfully Treated with Venovenous Extracorporeal Membrane Oxygenation. ( 29312788 )
2017
34
A process for developing multisectoral strategies for zoonoses: the case of leptospirosis in Fiji. ( 28830472 )
2017
35
Leptospirosis Cases in the Tokyo Metropolitan Area, Japan. ( 28890513 )
2017
36
DNA vaccines against leptospirosis: A literature review. ( 28882437 )
2017
37
Validity of Lateral Flow Immunochromatographic-Assays (LFIA) in diagnosis of leptospirosis ( 29394009 )
2017
38
Reproductive Disorders and Leptospirosis: A Case Study in a Mixed-Species Farm (Cattle and Swine). ( 29194353 )
2017
39
Varied presentations of leptospirosis: experience from a tertiary care hospital in north India. ( 28092222 )
2017
40
Seroprevalence of Leptospirosis, Brucellosis, and Q Fever in a Wild Red Deer (Cervus elaphus) Population Kept in a Fenced Reserve in Absence of Contact with Livestock. ( 28873022 )
2017
41
New trends in human and animal leptospirosis in Croatia, 2009-2014. ( 28063871 )
2017
42
Leptospirosis in three workers on a dairy farm with unvaccinated cattle. ( 28934773 )
2017
43
The influence of climatic factors on the development of hemorrhagic fever with renal syndrome and leptospirosis during the peak season in Korea: an ecologic study. ( 28592316 )
2017
44
Changes in leptospirosis etiology in animals and humans. ( 29284246 )
2017
45
Sero-epidemiology study of leptospirosis in febrile patients from Terai region of Nepal. ( 28923024 )
2017
46
Leptospirosis: Molecular trial path and immunopathogenesis correlated with dengue, malaria and mimetic hemorrhagic infections. ( 28823908 )
2017
47
Low-dose norfloxacin and ciprofloxacin therapy worsen leptospirosis in hamster. ( 27894961 )
2017
48
IgM ELISA for leptospirosis diagnosis: a systematic review and meta-analysis. ( 29267717 )
2017
49
Seroepidemiology of Leptospirosis among febrile patients in a rapidly growing suburban slum and a flood vulnerable rural district in Mozambique, 2012-2014: Implication for the management of fever. ( 28893674 )
2017
50
A Rapid In-Clinic Test Detects Acute Leptospirosis in Dogs with High Sensitivity and Specificity. ( 27110562 )
2016

Variations for Leptospirosis

Expression for Leptospirosis

Search GEO for disease gene expression data for Leptospirosis.

Pathways for Leptospirosis

Pathways related to Leptospirosis according to GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.65 CCL2 CD40LG CXCL8 F2 IL10 IL1B
2
Show member pathways
13.5 CCL2 CXCL8 F2 IL10 IL1B IL6
3
Show member pathways
13.42 CCL2 CD40LG CXCL8 IL10 IL1B IL6
4
Show member pathways
13.36 CCL2 CD40LG CXCL8 IL10 IL1B IL6
5
Show member pathways
13.3 CCL2 CD40LG CXCL8 IL10 IL1B IL6
6
Show member pathways
12.99 CCL2 CXCL8 IL1B IL6 TLR2 TNF
7
Show member pathways
12.89 CD40LG CXCL8 IL10 IL1B IL6 TNF
8
Show member pathways
12.83 CCL2 CXCL8 IL1B IL6 TLR2 TNF
9
Show member pathways
12.72 CD40LG IL1B IL6 TLR2 TNF
10
Show member pathways
12.65 CCL2 F2 IL10 IL1B IL6 TNF
11
Show member pathways
12.63 IL10 IL1B IL6 TLR2 TNF
12 12.62 CCL2 CD40LG IL10 IL1B TLR2 TNF
13
Show member pathways
12.55 CXCL8 IL6 TLR2 TNF
14
Show member pathways
12.49 CCL2 CXCL8 IL10 IL1B IL6 TLR2
15
Show member pathways
12.48 CD40LG IL10 IL1B IL6 TNF
16
Show member pathways
12.39 CCL2 CRP F2 IL1B IL6 TNF
17
Show member pathways
12.38 CCL2 CXCL8 IL1B IL6 TLR2 TNF
18
Show member pathways
12.32 CD40LG IL10 IL1B TLR2 TNF
19 12.3 IL10 IL1B IL6 TLR2 TNF
20
Show member pathways
12.29 CXCL8 IL6 TLR2 TNF
21
Show member pathways
12.29 CXCL8 IL1B IL6 TNF
22
Show member pathways
12.26 CXCL8 IL1B IL6 TLR2 TNF
23
Show member pathways
12.22 CXCL8 IL10 IL1B IL6 TNF
24 12.2 CXCL8 IL10 IL1B IL6 SLC9A3 TNF
25 12.01 CCL2 IL1B IL6 TNF
26
Show member pathways
12.01 IL10 IL1B IL6 TLR2 TNF
27
Show member pathways
12 IL1B PIK3C2A TLR2
28 11.98 CCL2 CXCL8 IL1B IL6 TNF
29 11.97 IL10 IL6 TNF
30 11.96 AQP1 CCL2 CXCL8 IL1B IL6 TNF
31 11.94 CD40LG CXCL8 IL1B TNF
32 11.93 CXCL8 IL1B IL6
33 11.9 CCL2 CXCL8 IL10 IL1B IL6 TNF
34 11.88 IL1B IL6 TNF
35
Show member pathways
11.85 IL1B IL6 TLR2
36 11.83 CXCL8 IL1B IL6
37 11.83 CXCL8 IL10 IL1B IL6 TNF
38 11.82 IL10 IL1B IL6 TNF
39 11.79 IL10 IL1B TNF
40 11.78 CXCL8 IL10 IL1B IL6 TLR2 TNF
41
Show member pathways
11.77 CD40LG CXCL8 TNF
42 11.74 CD40LG IL10 IL6 TLR2 TNF
43 11.69 CCL2 CXCL8 IL1B IL6 TNF
44 11.69 CCL2 CXCL8 IL1B IL6 TLR2 TNF
45
Show member pathways
11.67 CD40LG CXCL8 IL1B IL6 TNF
46 11.61 CCL2 IL1B TLR2 TNF
47 11.57 CXCL8 IL1B IL6 TLR2 TNF
48 11.53 IL1B IL6 TNF
49 11.46 IL10 IL1B IL6 TNF
50 11.45 IL10 IL1B IL6 TNF

GO Terms for Leptospirosis

Cellular components related to Leptospirosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 CCL2 CD40LG CRP CXCL8 F2 IL10
2 extracellular space GO:0005615 9.28 CCL2 CD40LG CRP CXCL8 F2 IL10

Biological processes related to Leptospirosis according to GeneCards Suite gene sharing:

(show all 43)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.98 CRP IL1B IL6 TLR2 TNF
2 platelet activation GO:0030168 9.86 CD40LG F2 IL6
3 cellular response to organic cyclic compound GO:0071407 9.84 CCL2 IL1B TNF
4 positive regulation of DNA binding transcription factor activity GO:0051091 9.84 IL10 IL1B IL6 TNF
5 neutrophil chemotaxis GO:0030593 9.82 CCL2 CXCL8 IL1B
6 response to glucocorticoid GO:0051384 9.82 IL10 IL6 TNF
7 positive regulation of T cell proliferation GO:0042102 9.81 CD40LG IL1B IL6
8 defense response to Gram-positive bacterium GO:0050830 9.81 CRP IL6 TLR2 TNF
9 humoral immune response GO:0006959 9.8 CCL2 IL6 TNF
10 protein kinase B signaling GO:0043491 9.77 CCL2 IL1B TNF
11 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.77 CD40LG IL1B IL6 TLR2 TNF
12 immune response GO:0006955 9.76 CCL2 CD40LG CXCL8 IL10 IL1B IL6
13 acute-phase response GO:0006953 9.73 CRP F2 IL6
14 positive regulation of interleukin-8 production GO:0032757 9.72 IL1B TLR2 TNF
15 cellular response to lipopolysaccharide GO:0071222 9.72 CCL2 CXCL8 IL10 IL6 TNF
16 positive regulation of interleukin-6 production GO:0032755 9.71 IL1B IL6 TLR2 TNF
17 positive regulation of NF-kappaB import into nucleus GO:0042346 9.7 IL1B TLR2 TNF
18 embryonic digestive tract development GO:0048566 9.69 CXCL8 TNF
19 negative regulation of lipid catabolic process GO:0050995 9.69 IL1B TNF
20 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.68 IL1B TNF
21 negative regulation of growth of symbiont in host GO:0044130 9.68 IL10 TNF
22 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.68 IL1B TNF
23 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.67 CCL2 TLR2
24 cellular homeostasis GO:0019725 9.67 AQP1 CCL2
25 PERK-mediated unfolded protein response GO:0036499 9.67 CCL2 CXCL8
26 positive regulation of chemokine production GO:0032722 9.67 IL6 TLR2 TNF
27 positive regulation of chemokine biosynthetic process GO:0045080 9.66 IL1B TNF
28 endothelial cell apoptotic process GO:0072577 9.65 IL10 TNF
29 regulation of establishment of endothelial barrier GO:1903140 9.65 IL1B TNF
30 response to molecule of bacterial origin GO:0002237 9.65 CXCL8 IL10 TLR2
31 negative regulation of cytokine secretion involved in immune response GO:0002740 9.63 IL10 TNF
32 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.63 IL10 IL1B TNF
33 positive regulation of STAT protein import into nucleus GO:2000366 9.62 F2 IL6
34 positive regulation of fever generation GO:0031622 9.62 IL1B TNF
35 regulation of immunoglobulin secretion GO:0051023 9.61 CD40LG TNF
36 negative regulation of lipid storage GO:0010888 9.61 CRP IL6 TNF
37 sequestering of triglyceride GO:0030730 9.59 IL1B TNF
38 receptor biosynthetic process GO:0032800 9.58 IL10 TNF
39 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.57 IL1B TNF
40 lipopolysaccharide-mediated signaling pathway GO:0031663 9.56 CCL2 IL1B TLR2 TNF
41 regulation of receptor activity GO:0010469 9.56 CCL2 CD40LG CXCL8 F2 IL10 IL1B
42 inflammatory response GO:0006954 9.28 CCL2 CD40LG CRP CXCL8 IL10 IL1B
43 negative regulation of cell proliferation GO:0008285 10 CXCL8 IL10 IL1B IL6 TLR2

Molecular functions related to Leptospirosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.17 CCL2 CD40LG CXCL8 IL10 IL1B IL6

Sources for Leptospirosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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