MCID: LPT001
MIFTS: 53

Leptospirosis malady

Rare diseases, Infectious diseases categories
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Summaries for Leptospirosis

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Sources:
8Disease Ontology, 4CDC, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A primary bacterial infectious disease that involves systemic infection, has material basis in leptospira, which is transmitted by contact with water, food, or soil containing urine from the infected animals. the infection has symptom jaundice, has symptom chills, has symptom fever, has symptom muscle pain, and has symptom hepatomegaly.

MalaCards: Leptospirosis, also known as hemorrhagic jaundice, is related to typhus and scrub typhus, and has symptoms including muscle pain, chills and hepatomegaly. An important gene associated with Leptospirosis is OMP (olfactory marker protein), and among its related pathways are Signaling by FGFR and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. The compound mannan have been mentioned in the context of this disorder. Affiliated tissues include kidney, lung and testes.

CDC:4 Leptospirosis is a bacterial disease that affects humans and animals. It is caused by bacteria of the genus Leptospira. In humans, it can cause a wide range of symptoms, some of which may be mistaken for other diseases. Some infected persons, however, may have no symptoms at all.

Wikipedia:65 Leptospirosis (also known as field fever,rat catcher\'s yellows, and pretibial fever among others names)... more...

Aliases & Classifications for Leptospirosis

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 62UMLS, 58SNOMED-CT, 40NCIt, 27ICD9CM, 35MeSH, 36MESH via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet, 26ICD10 via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases


Characteristics (Orphanet epidemiological data):

49
leptospirosis:
Inheritance: Sporadic; Prevalence: 1-9/1000000; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

leptospirosis 8 43 10 45 49 62
hemorrhagic jaundice 43 62
fort bragg fever 8 62
canicola fever 43 62
leptospirosis icterohaemorrhagica 8
leptospirosis icterohemorrhagica 8
icterohemorrhagic fever 43
rat catcher's yellows 8
spirochetal jaundice 8
swineherd's disease 43
cane-cutter fever 43
stuttgart disease 43
rice-field fever 43
nanukayami fever 8
weil's disease 8
weil disease 43
swamp fever 43
leptospiral 8
mud fever 43


External Ids:

Disease Ontology8 DOID:2297
NCIt40 C84825
ICD9CM27 100.9, 100
MeSH35 D007922
MESH via Orphanet36 D007922
SNOMED-CT via Orphanet59 77377001
UMLS via Orphanet63 C0023364
ICD10 via Orphanet26 A27.0, A27.8, A27.9
ICD1025 A27, A27.0, A27.9

Related Diseases for Leptospirosis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Leptospirosis:



Diseases related to leptospirosis

Symptoms for Leptospirosis

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8Disease Ontology
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Symptoms:

8
  • muscle pain
  • chills
  • hepatomegaly
  • jaundice
  • fever

Drugs & Therapeutics for Leptospirosis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Leptospirosis

Search NIH Clinical Center for Leptospirosis

Genetic Tests for Leptospirosis

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Anatomical Context for Leptospirosis

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Sources:
33MalaCards
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MalaCards organs/tissues related to Leptospirosis:

33
Kidney, Lung, Testes, Liver, T cells, Heart, Whole blood, Eye, B cells, Skin

Animal Models for Leptospirosis or affiliated genes

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Publications for Leptospirosis

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52PubMed
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Articles related to Leptospirosis:

(show top 50)    (show all 557)
idTitleAuthorsYear
1
Leptospirosis in sheep and goats under tropical conditions. (24085419)
2013
2
Signalment Changes in Canine Leptospirosis between 1970 and 2009. (24372922)
2013
3
Outbreak of leptospirosis among canyoning participants, Martinique, 2011. (23725775)
2013
4
Molecular typing of Leptospira spp. strains isolated from field mice confirms a link to human leptospirosis. (23406882)
2013
5
A conserved region of leptospiral immunoglobulin-like A and B proteins as a DNA vaccine elicits a prophylactic immune response against leptospirosis. (23486420)
2013
6
Plasma exchange in severe leptospirosis with multi-organ failure: a case report. (23809518)
2013
7
Antimicrobial Prophylaxis For Melioidosis and Leptospirosis For At Risk Rescue Workers. (23466779)
2013
8
Severe Pulmonary Involvement in Leptospirosis: Alternate antibiotics and systemic steroids. (23862041)
2013
9
Flock-level risk factors associated with leptospirosis in dairy goats in a semiarid region of Northeastern Brazil. (23031326)
2013
10
Human hemorrhagic pulmonary leptospirosis: pathological findings and pathophysiological correlations. (23951234)
2013
11
Application of an integrated outbreak management plan for the control of leptospirosis in dairy cattle herds. (23920354)
2013
12
Microhaemorrhages in Leptospirosis on susceptibility weighted imaging. (22285590)
2012
13
Modeling seasonal leptospirosis transmission and its association with rainfall and temperature in Thailand using time-series and ARIMAX analyses. (22647816)
2012
14
Prolonged jaundice attributed to super infection of hepatitis E virus in a case of resolving leptospirosis. (22361773)
2012
15
The dog in the transmission of human leptospirosis under tropical conditions: victim or villain? (21396149)
2012
16
Evaluation of 'white-spotted kidneys' associated with leptospirosis by polymerase chain reaction based LipL32 gene in slaughtered cows. (23327135)
2012
17
Cases distribution of leptospirosis in City of Manaus, State of Amazonas, Brazil, 2000-2010. (23295874)
2012
18
Serology and PCR for bovine leptospirosis: herd and individual approaches. (22427387)
2012
19
Outbreak of melioidosis and leptospirosis co-infection following a rescue operation. (23082420)
2012
20
Severe leptospirosis in a Dutch traveller returning from the Dominican Republic, October 2011. (22490382)
2012
21
Leptospirosis diagnosis by immunocapture polymerase chain reaction: a new tool for early diagnosis and epidemiologic surveillance. (22770775)
2012
22
Differences between seroreactivity to leptospirosis in dairy and beef cattle from the same herd in Rio de Janeiro, Brazil. (21739134)
2012
23
Paralysis due to renal hypokalaemia: an unusual presentation of leptospirosis. (22715569)
2012
24
Antibiotics for leptospirosis. (22336839)
2012
25
A sensitive and specific IgM-ELISA for the serological diagnosis of human leptospirosis using a rLipL32/1-LipL21-OmpL1/2 fusion protein. (21784316)
2011
26
Vaccination for leptospirosis improved the weaning percentage of 2-year-old farmed red deer hinds in New Zealand. (21660849)
2011
27
Sporadic urban leptospirosis. (23882321)
2011
28
Serological evidence of Thailand virus-related hantavirus infection among suspected leptospirosis patients in Kandy, Sri Lanka. (21266762)
2011
29
Leptospirosis. (21391357)
2011
30
Travel-related leptospirosis in Israel: a nationwide study. (20207873)
2010
31
Differential cytokine gene expression according to outcome in a hamster model of leptospirosis. (20076757)
2010
32
The contribution of bats to leptospirosis transmission in Sao Paulo City, Brazil. (20134010)
2010
33
Evaluation of a recombinant LigB protein of Leptospira interrogans serovar Canicola in an enzyme-linked immunosorbent assay for the serodiagnosis of bovine leptospirosis. (20022618)
2010
34
Serodiagnosis of bovine leptospirosis by IgG-enzyme-linked immunosorbent assay and latex agglutination test. (19680775)
2010
35
Leptospirosis-associated acute kidney injury. (21541455)
2010
36
Leptospirosis pulmonary haemorrhage syndrome is associated with linear deposition of immunoglobulin and complement on the alveolar surface. (19778300)
2010
37
Leptospirosis: a globally increasing zoonotic disease. (22791852)
2010
38
A case of severe leptospirosis infection (Weil's disease) in Tokyo]. (20170016)
2010
39
Leptospirosis in a European intensive care unit. (19883151)
2010
40
Vasculitis secondary to presumptive leptospirosis treated with long-term corticosteroids in a captive lesser kudu (Tragelaphus imberbis australis). (20945659)
2010
41
Seasonal and environmental determinants of leptospirosis and scrub typhus in small mammals captured at a U.S. military training site (Dagmar North), Republic of Korea, 2001-2004. (19891218)
2009
42
Leptospirosis distribution related to freshwater habitats in the Vojvodina region (Republic of Serbia). (19911133)
2009
43
Evaluation of surveillance case definition in the diagnosis of leptospirosis, using the Microscopic Agglutination Test: a validation study. (19386085)
2009
44
Leptospirosis: a worldwide resurgent zoonosis and important cause of acute renal failure and death in developing nations. (19484873)
2009
45
Increase in seroprevalence of canine leptospirosis and its risk factors, Ontario 1998-2006. (19794888)
2009
46
Evaluation of recombinant Leptospira antigen-based enzyme-linked immunosorbent assays for the serodiagnosis of leptospirosis. (11526167)
2001
47
Leptospiral proteins recognized during the humoral immune response to leptospirosis in humans. (11447174)
2001
48
Acute acalculous cholecystitis in leptospirosis. (10509958)
1999
49
Leptospirosis with acute acalculous cholecystitis and pancreatitis. (8421147)
1993
50
Occurrence of antibodies to the etiologic agents of infectious bovine rhinotracheitis, parainfluenza 3, leptospirosis, and brucellosis in white-tailed deer in Minnesota. (3005666)
1986

Variations for Leptospirosis

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Expression for genes affiliated with Leptospirosis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Leptospirosis

Search GEO for disease gene expression data for Leptospirosis.

Pathways for genes affiliated with Leptospirosis

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Sources:
50PathCards, 55Reactome, 30KEGG, 60Thomson Reuters, 38NCBI BioSystems Database, 53QIAGEN
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Pathways related to Leptospirosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
7.6KIR2DS3, KIR2DL3, KIR2DL2, KIR2DL1, KIR3DS1
27.4CD40LG, KIR2DS3, KIR2DL1, KIR2DL4, KIR2DL2, KIR2DL3
3
Show member pathways
7.4KIR2DS3, KIR2DL3, KIR2DL2, KIR2DL4, KIR2DL1, CD40LG
4
Show member pathways
Immune response CD16 signaling in NK cells60
7.4KIR2DS3, KIR2DL3, KIR2DL2, KIR2DL4, KIR2DL5A, KIR2DL1
5
Show member pathways
7.0KIR2DL5A, KIR2DS3, KIR2DL3, KIR2DL2, CD40LG, KIR2DL1

Compounds for genes affiliated with Leptospirosis

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45Novoseek
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Compounds related to Leptospirosis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1mannan459.7CD40LG, KIR2DL2

GO Terms for genes affiliated with Leptospirosis

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16Gene Ontology
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Cellular components related to Leptospirosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058876.9CD40LG, KIR3DS1, KIR2DL1, KIR2DL4, KIR2DL3, KIR2DS3
2plasma membraneGO:0058866.8KIR2DL2, KIR2DL4, KIR2DL5A, KIR2DL1, KIR3DS1, CD40LG

Biological processes related to Leptospirosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular defense responseGO:0069689.2KIR2DL4, KIR2DS3
2signal transductionGO:0071659.0KIR3DS1, KIR2DL4, OMP
3immune responseGO:0069558.4KIR2DL3, KIR2DL1, KIR3DS1
4regulation of immune responseGO:0507767.8CD40LG, KIR2DL1, KIR2DL4, KIR2DL2, KIR2DL3

Molecular functions related to Leptospirosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor activityGO:0048729.1KIR2DL1, KIR2DL3

Products for genes affiliated with Leptospirosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Leptospirosis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet