MCID: LPT001
MIFTS: 55

Leptospirosis malady

Infectious diseases category

Summaries for Leptospirosis

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A primary bacterial infectious disease that involves systemic infection, has material basis in leptospira, which is transmitted by contact with water, food, or soil containing urine from the infected animals. the infection has symptom jaundice, has symptom chills, has symptom fever, has symptom muscle pain, and has symptom hepatomegaly.

MalaCards: Leptospirosis, also known as hemorrhagic jaundice, is related to hepatitis and influenza, and has symptoms including muscle pain, hepatomegaly and jaundice. An important gene associated with Leptospirosis is OMP (olfactory marker protein), and among its related pathways are Signaling by FGFR and Classical antibody-mediated complement activation. The compound mannan have been mentioned in the context of this disorder. Affiliated tissues include kidney, lung and testes.

CDC:3 Leptospirosis is a bacterial disease that affects humans and animals. It is caused by bacteria of the genus Leptospira. In humans, it can cause a wide range of symptoms, some of which may be mistaken for other diseases. Some infected persons, however, may have no symptoms at all.

Wikipedia:63 Leptospirosis (also known as field fever,rat catcher\'s yellows, and pretibial fever among others names)... more...

Aliases & Classifications for Leptospirosis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 39NCIt, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 26ICD10 via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Characteristics (Orphanet epidemiological data):

48
leptospirosis:
Inheritance: Sporadic; Prevalence: 1-9/1000000; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

leptospirosis 8 42 10 44 48 60
hemorrhagic jaundice 42 60
fort bragg fever 8 60
canicola fever 42 60
leptospirosis icterohaemorrhagica 8
leptospirosis icterohemorrhagica 8
icterohemorrhagic fever 42
rat catcher's yellows 8
spirochetal jaundice 8
cane-cutter fever 42
nanukayami fever 8
weil's disease 8
leptospiral 8
mud fever 42


External Ids:

Disease Ontology8 DOID:2297
ICD9CM27 100.9, 100
MeSH34 D007922
NCIt39 C84825
MESH via Orphanet35 D007922
SNOMED-CT via Orphanet57 77377001
UMLS via Orphanet61 C0023364
ICD10 via Orphanet26 A27.0, A27.8, A27.9
ICD1025 A27, A27.0, A27.9

Related Diseases for Leptospirosis

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Leptospirosis:



Diseases related to leptospirosis

Clinical Features for Leptospirosis

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Sources:
8Disease Ontology
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Symptoms:

8
  • muscle pain
  • hepatomegaly
  • jaundice
  • chills
  • fever

Drugs & Therapeutics for Leptospirosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Leptospirosis

Drug clinical trials:

Search ClinicalTrials for Leptospirosis

Search NIH Clinical Center for Leptospirosis

Search CenterWatch for Leptospirosis

Genetic Tests for Leptospirosis

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Anatomical Context for Leptospirosis

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32MalaCards
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MalaCards organs/tissues related to Leptospirosis:

32
Kidney, Lung, Testes, Liver, T cells, Heart, Whole blood, Eye, B cells, Skin

Animal Models for Leptospirosis or affiliated genes

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Publications for Leptospirosis

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50PubMed
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Articles related to Leptospirosis:

(show top 50)    (show all 566)
idTitleAuthorsYear
1
Leptospirosis in sheep and goats under tropical conditions. (24085419)
2013
2
Leptospirosis seroprevalence and risk factors for sheep in MaranhALo state, Brazil. (24326771)
2013
3
Improvement of leptospirosis surveillance in remote Pacific islands using serum spotted on filter paper. (24384412)
2013
4
Laboratory diagnosis of leptospirosis: a challenge. (23639380)
2013
5
Leptospirosis acquired by tourists in Venice, Italy. (23464722)
2013
6
Diagnosis and epidemiology of leptospirosis. (23337900)
2013
7
Leptospirosis in fox squirrels (Sciurus niger) of Larimer County, Colorado, USA. (23778614)
2013
8
Serology and PCR for bovine leptospirosis: herd and individual approaches. (22427387)
2012
9
Serum nitrite levels in Sri Lankan patients with leptospirosis. (22182649)
2012
10
Leptospirosis in a French traveler returning from Mauritius. (22221817)
2012
11
Diagnosis and control of an outbreak of leptospirosis in goats with reproductive failure. (22365844)
2012
12
Leptospirosis presenting as neuroretinitis. (22865992)
2012
13
Predictors of the development of myocarditis or acute renal failure in patients with leptospirosis: an observational study. (22243770)
2012
14
Anicteric leptospirosis-associated severe pulmonary hemorrhagic syndrome: a case series study. (22739564)
2012
15
Rapid diagnosis of leptospirosis by multiplex PCR. (23610544)
2012
16
Unforeseen risk: leptospirosis and the u.s. Special operations community. (23032318)
2012
17
Vaccination for leptospirosis improved the weaning percentage of 2-year-old farmed red deer hinds in New Zealand. (21660849)
2011
18
Use of patient-specific Leptospira isolates in the diagnosis of leptospirosis employing microscopic agglutination testing (MAT). (21334705)
2011
19
Emergence, control and re-emerging leptospirosis: dynamics of infection in the changing world. (21414083)
2011
20
Leptospirosis in a Dutch catfish farm. (21527810)
2011
21
Rodent abundance dynamics and leptospirosis carriage in an area of hyper-endemicity in New Caledonia. (22039557)
2011
22
Clinical and imaging manifestations of hemorrhagic pulmonary leptospirosis: a state-of-the-art review. (21152929)
2011
23
Leptospirosis-induced still birth and postpartum sepsis. (21623124)
2011
24
Leptospirosis is associated with markedly increased triglycerides and small dense low-density lipoprotein and decreased high-density lipoprotein. (21688175)
2011
25
Mildly elevated transaminases: excellent diagnostic clue for anicteric leptospirosis. (22479757)
2011
26
Serum C-reactive protein (CRP) and procalcitonin (PCT) levels and kinetics in patients with leptospirosis. (21076930)
2011
27
Development of rapid flow-through-based dot-immunoassay for serodiagnosis of leptospirosis in dogs. (19906426)
2011
28
Leptospirosis pulmonary haemorrhage syndrome is associated with linear deposition of immunoglobulin and complement on the alveolar surface. (19778300)
2010
29
Leptospirosis: a globally increasing zoonotic disease. (22791852)
2010
30
Early identification of leptospirosis-associated pulmonary hemorrhage syndrome by use of a validated prediction model. (20026189)
2010
31
Prophylaxis against Leptospirosis using a nosode: can this large cohort study serve as a model for future replications? (20674838)
2010
32
Control of canine leptospirosis in Europe: time for a change? (21257439)
2010
33
Serologic and molecular studies of Leptospira and leptospirosis among rats in the Philippines. (20439972)
2010
34
Clinical and serological evaluation of Leptospirosis in Puducherry, India. (20351453)
2010
35
Outbreak of leptospirosis among Adventure Race participants in Florida, 2005. (20146629)
2010
36
Leptospirosis. (19222355)
2009
37
Leptospira noguchii and human and animal leptospirosis, Southern Brazil. (19331754)
2009
38
Leptospirosis and Goodpasture's syndrome: testing the aetiological hypothesis. (19825286)
2009
39
An imprint method for detecting leptospires in the hamster model of vaccine-mediated immunity for leptospirosis. (19679685)
2009
40
Seroprevalence of Q-fever, brucellosis and leptospirosis in farmers and agricultural workers in Bari, southern Italy. (19793130)
2009
41
Leptospiral glycolipoprotein as a candidate antigen for serodiagnosis of human leptospirosis. (19496929)
2009
42
Case of fulminant leptospirosis in a renal transplant patient. (19558375)
2009
43
Leptospirosis in children: a review for family physicians. (19770531)
2009
44
Clinical significance of the activity of nitric oxide synthase in patients with leptospirosis]. (18314776)
2008
45
Leptospirosis and pancytopenia: two case reports and review of the literature. (15896845)
2005
46
Leptospirosis presenting as diffuse alveolar hemorrhage: case report and literature review. (12576395)
2003
47
Double trouble: hemorrhagic fever with renal syndrome and leptospirosis. (12030403)
2002
48
Lateral-flow assay for rapid serodiagnosis of human leptospirosis. (11139212)
2001
49
Occurrence of antibodies to the etiologic agents of infectious bovine rhinotracheitis, parainfluenza 3, leptospirosis, and brucellosis in white-tailed deer in Minnesota. (3005666)
1986
50
Serologic studies on brucellosis, leptospirosis and tularemia in moose (Alces alces) in Quebec. (6429355)
1984

Genetic Variations for Leptospirosis

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Expression for genes affiliated with Leptospirosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Leptospirosis

Search GEO for disease gene expression data for Leptospirosis.

Pathways for genes affiliated with Leptospirosis

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53Reactome, 12EMD Millipore, 29KEGG
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Compounds for genes affiliated with Leptospirosis

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44Novoseek
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Compounds related to Leptospirosis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1mannan4410.4KIR2DL2, CD40LG

GO Terms for genes affiliated with Leptospirosis

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16Gene Ontology
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Cellular components related to Leptospirosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to membraneGO:01602110.0KIR2DL3, KIR2DL5A, KIR2DL2, KIR2DS2, KIR3DL3, KIR2DS1
2integral to plasma membraneGO:0058879.9CD40LG, KIR2DL3, KIR2DL1, KIR2DS3, KIR3DS1, KIR2DL4
3plasma membraneGO:0058869.7AQP2, PIK3C2A, CD40LG, KIR2DL3, KIR2DL1, KIR2DL5A

Biological processes related to Leptospirosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695510.2KIR2DS5, KIR2DS1, KIR3DS1, KIR2DS2, KIR2DL1, KIR2DL3
2regulation of immune responseGO:0507769.9KIR2DS1, CD40LG, KIR2DL3, KIR2DL1, KIR2DL2, KIR2DS2

Molecular functions related to Leptospirosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:00488810.3KIR2DS1, KIR2DL4, KIR2DS2

Products for genes affiliated with Leptospirosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Leptospirosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet