MCID: LPT001
MIFTS: 55

Leptospirosis malady

Infectious diseases category

Summaries for Leptospirosis

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A primary bacterial infectious disease that involves systemic infection, has material basis in leptospira, which is transmitted by contact with water, food, or soil containing urine from the infected animals. the infection has symptom jaundice, has symptom chills, has symptom fever, has symptom muscle pain, and has symptom hepatomegaly.

MalaCards: Leptospirosis, also known as hemorrhagic jaundice, is related to hepatitis and influenza, and has symptoms including muscle pain, hepatomegaly and jaundice. An important gene associated with Leptospirosis is OMP (olfactory marker protein), and among its related pathways are Signaling by FGFR and Classical antibody-mediated complement activation. The compound mannan have been mentioned in the context of this disorder. Affiliated tissues include kidney, lung and testes.

CDC:3 Leptospirosis is a bacterial disease that affects humans and animals. It is caused by bacteria of the genus Leptospira. In humans, it can cause a wide range of symptoms, some of which may be mistaken for other diseases. Some infected persons, however, may have no symptoms at all.

Wikipedia:63 Leptospirosis (also known as field fever,rat catcher\'s yellows, and pretibial fever among others names)... more...

Aliases & Classifications for Leptospirosis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 39NCIt, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 26ICD10 via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Characteristics (Orphanet epidemiological data):

48
leptospirosis:
Inheritance: Sporadic; Prevalence: 1-9/1000000; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

leptospirosis 8 42 10 44 48 60
hemorrhagic jaundice 42 60
fort bragg fever 8 60
canicola fever 42 60
leptospirosis icterohaemorrhagica 8
leptospirosis icterohemorrhagica 8
icterohemorrhagic fever 42
rat catcher's yellows 8
spirochetal jaundice 8
cane-cutter fever 42
nanukayami fever 8
weil's disease 8
leptospiral 8
mud fever 42


External Ids:

Disease Ontology8 DOID:2297
ICD9CM27 100.9, 100
MeSH34 D007922
NCIt39 C84825
MESH via Orphanet35 D007922
SNOMED-CT via Orphanet57 77377001
UMLS via Orphanet61 C0023364
ICD10 via Orphanet26 A27.0, A27.8, A27.9
ICD1025 A27, A27.0, A27.9

Related Diseases for Leptospirosis

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Leptospirosis:



Diseases related to leptospirosis

Clinical Features for Leptospirosis

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Sources:
8Disease Ontology
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Symptoms:

8
  • muscle pain
  • hepatomegaly
  • jaundice
  • chills
  • fever

Drugs & Therapeutics for Leptospirosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Leptospirosis

Drug clinical trials:

Search ClinicalTrials for Leptospirosis

Search NIH Clinical Center for Leptospirosis

Search CenterWatch for Leptospirosis

Genetic Tests for Leptospirosis

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Anatomical Context for Leptospirosis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Leptospirosis:

32
Kidney, Lung, Testes, Liver, T cells, Heart, Whole blood, Eye, B cells, Skin

Animal Models for Leptospirosis or affiliated genes

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Publications for Leptospirosis

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50PubMed
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Articles related to Leptospirosis:

(show top 50)    (show all 566)
idTitleAuthorsYear
1
B cell specific peptides of Leptospira interrogans LigA for the diagnosis of cases with acute leptospirosis. (24403522)
2014
2
Plasma exchange in severe leptospirosis with multi-organ failure: a case report. (23809518)
2013
3
The look of leptospirosis in Victoria - recent trends. (24099205)
2013
4
Ionic imbalance and lack of effect of adjuvant treatment with methylene blue in the hamster model of leptospirosis. (23827990)
2013
5
Leptospirosis and malaria as causes of febrile illness during a dengue epidemic in Jamaica. (24188242)
2013
6
Cytokine response signatures in disease progression and development of severe clinical outcomes for leptospirosis. (24069500)
2013
7
Serological evaluation of leptospirosis: a report from Western India. (24049368)
2013
8
Prevalence of leptospirosis in vague dogs]. (24248177)
2013
9
Paralysis due to renal potassium wasting : an unusual presentation of leptospirosis. (24000511)
2013
10
Immunomodulatory treatment with thalidomide in experimental leptospirosis in Golden Syrian hamsters (Mesocricetus auratus). (24361944)
2013
11
Recombinant OmpL1 protein as a diagnostic antigen for the detection of canine leptospirosis. (23212848)
2013
12
Sensitivity and Specificity of a New Vertical Flow Rapid Diagnostic Test for the Serodiagnosis of Human Leptospirosis. (23826401)
2013
13
Urinary PCR as an increasingly useful tool for an accurate diagnosis of leptospirosis in livestock. (24222053)
2013
14
Diagnosis of leptospirosis. (24056608)
2013
15
Seroprevalence and exposure to risk factors for leptospirosis among veterinary students at Massey University. (24350827)
2013
16
Rapid diagnostic of leptospirosis in an aborted bovine fetus by PCR in Rio de Janeiro, Brazil. (23294859)
2013
17
The dog in the transmission of human leptospirosis under tropical conditions: victim or villain? (21396149)
2012
18
Antibiotics for leptospirosis. (22336839)
2012
19
Prevalence of leptospirosis in farm animals. (22458201)
2012
20
Leptospirosis and embryo recovery rate in mares. (22247209)
2012
21
The impact of climate on Leptospirosis in SALo Paulo, Brazil. (21369729)
2012
22
A ten-year follow-up of human leptospirosis in Uruguay: an unresolved health problem. (22499419)
2012
23
Leptospirosis as a tick-borne disease? Detection of Leptospira spp. in Ixodes ricinus ticks in eastern Poland. (23311784)
2012
24
Leptospirosis, diagnostic challenges, American Samoa. (23171761)
2012
25
A sensitive and specific IgM-ELISA for the serological diagnosis of human leptospirosis using a rLipL32/1-LipL21-OmpL1/2 fusion protein. (21784316)
2011
26
Leptospirosis: pulmonary hemorrhage in a returned traveller. (21262944)
2011
27
Fulminant Leptospirosis (Weil's disease) in an urban setting as an overlooked cause of multiorgan failure: a case report. (21235739)
2011
28
Human leptospirosis in the Caribbean, 1997-2005: characteristics and serotyping of clinical samples from 14 countries. (21709940)
2011
29
Severe leptospirosis similar to pandemic (H1N1) 2009, Florida and Missouri, USA. (21749799)
2011
30
Occurrence of leptospirosis among suspected cases in Chennai, Tamil Nadu. (21393887)
2011
31
Leptospirosis in a dog with uveitis and presumed cholecystitis. (22058365)
2011
32
Acalculous cholecystitis: a rare presentation of leptospirosis progressing to Weil's disease. (22118040)
2011
33
An outbreak of severe leptospirosis in capuchin (Cebus) monkeys. (20554228)
2011
34
Leptospirosis: an emerging public health problem. (21302385)
2011
35
Serodiagnosis of bovine leptospirosis by IgG-enzyme-linked immunosorbent assay and latex agglutination test. (19680775)
2010
36
Lemierre's syndrome mimicking leptospirosis. (20680923)
2010
37
Strategies for diagnosis and treatment of suspected leptospirosis: a cost-benefit analysis. (20186324)
2010
38
Clinical manifestations of dengue and leptospirosis in children in Mumbai: an observational study. (20505977)
2010
39
Revised incidence of leptospirosis in Trinidad and Tobago, West Indies. (20102817)
2010
40
Leptospirosis: a worldwide resurgent zoonosis and important cause of acute renal failure and death in developing nations. (19484873)
2009
41
Leptospirosis scientific meeting, Manila, November 2008. (19198049)
2009
42
Long pentraxin PTX3 is associated with mortality and disease severity in severe Leptospirosis. (19443038)
2009
43
Seroprevalence of Q fever, brucellosis and leptospirosis in farmers and agricultural workers in Bari, Southern Italy. (20047252)
2009
44
Acute abdomen due to acute pancreatitis--a rare presentation of leptospirosis. (19263694)
2008
45
Successful treatment of pulmonary hemorrhage associated with leptospirosis and scrub typhus coinfection by early plasma exchange. (17493889)
2007
46
Reversal of renal tubule transporter downregulation during severe leptospirosis with antimicrobial therapy. (18165532)
2007
47
Acute acalculous cholecystitis and pancreatitis in a patient with concomitant leptospirosis and scrub typhus. (14723261)
2003
48
Leptospiral proteins recognized during the humoral immune response to leptospirosis in humans. (11447174)
2001
49
Leptospirosis associated with acute acalculous cholecystitis. Surgical or medical treatment? (9451699)
1997
50
Cerebrovascular accident as a complication of leptospirosis. (6118561)
1981

Genetic Variations for Leptospirosis

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Expression for genes affiliated with Leptospirosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Leptospirosis

Search GEO for disease gene expression data for Leptospirosis.

Pathways for genes affiliated with Leptospirosis

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53Reactome, 12EMD Millipore, 29KEGG
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Compounds for genes affiliated with Leptospirosis

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44Novoseek
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Compounds related to Leptospirosis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1mannan4410.4KIR2DL2, CD40LG

GO Terms for genes affiliated with Leptospirosis

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16Gene Ontology
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Cellular components related to Leptospirosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to membraneGO:01602110.0KIR2DL3, KIR2DL5A, KIR2DL2, KIR2DS2, KIR3DL3, KIR2DS1
2integral to plasma membraneGO:0058879.9CD40LG, KIR2DL3, KIR2DL1, KIR2DS3, KIR3DS1, KIR2DL4
3plasma membraneGO:0058869.7AQP2, PIK3C2A, CD40LG, KIR2DL3, KIR2DL1, KIR2DL5A

Biological processes related to Leptospirosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695510.2KIR2DS5, KIR2DS1, KIR3DS1, KIR2DS2, KIR2DL1, KIR2DL3
2regulation of immune responseGO:0507769.9KIR2DS1, CD40LG, KIR2DL3, KIR2DL1, KIR2DL2, KIR2DS2

Molecular functions related to Leptospirosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:00488810.3KIR2DS1, KIR2DL4, KIR2DS2

Products for genes affiliated with Leptospirosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Leptospirosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet