MCID: LPT001
MIFTS: 50

Leptospirosis malady

Infectious category

Summaries for Leptospirosis

Sources:
8Disease Ontology, 3CDC, 64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 A primary bacterial infectious disease that involves systemic infection, has material basis in leptospira, which is transmitted by contact with water, food, or soil containing urine from the infected animals. the infection has symptom jaundice, has symptom chills, has symptom fever, has symptom muscle pain, and has symptom hepatomegaly.

MalaCards: Leptospirosis, also known as hemorrhagic jaundice, is related to hepatitis c and thrombocytopenia, and has symptoms including fever, chills and jaundice. An important gene associated with Leptospirosis is OMP (olfactory marker protein), and among its related pathways are Signaling by FGFR and Classical antibody-mediated complement activation. The compound mannan have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and kidney.

CDC:3 Leptospirosis is a bacterial disease that affects humans and animals. It is caused by bacteria of the genus Leptospira. In humans, it can cause a wide range of symptoms, some of which may be mistaken for other diseases. Some infected persons, however, may have no symptoms at all.

Wikipedia:64 Leptospirosis (also known as Weil\'s syndrome, canicola fever, canefield fever, nanukayami fever, 7-day... more...

Aliases & Classifications for Leptospirosis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 57SNOMED-CT, 27ICD9CM, 35MeSH, 40NCIt, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Characteristics (Orphanet epidemiological data):

49
leptospirosis:
Inheritance: Sporadic; Prevalence: 1-9/1000000; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

leptospirosis 8 43 10 45 49 61
hemorrhagic jaundice 43 61
fort bragg fever 8 61
canicola fever 43 61
leptospirosis icterohaemorrhagica 8
leptospirosis icterohemorrhagica 8
icterohemorrhagic fever 43
rat catcher's yellows 8
spirochetal jaundice 8
cane-cutter fever 43
nanukayami fever 8
weil's disease 8
leptospiral 8
mud fever 43


External Ids:

Disease Ontology8 DOID:2297
ICD9CM27 100.9, 100
MeSH35 D007922
NCIt40 C84825
MESH via Orphanet36 D007922
ICD10 via Orphanet26 A27
SNOMED-CT via Orphanet58 77377001
UMLS via Orphanet62 C0023364
ICD1025 A27, A27.0, A27.9

Related Diseases for Leptospirosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Leptospirosis:



Diseases related to leptospirosis

Clinical Features for Leptospirosis

Sources:
8Disease Ontology
See all sources


Symptoms:

8 (see all 5)
  • fever
  • chills
  • jaundice
  • hepatomegaly
  • muscle pain

Drugs & Therapeutics for Leptospirosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Leptospirosis

Drug clinical trials:

Search ClinicalTrials for Leptospirosis

Search NIH Clinical Center for Leptospirosis

Search CenterWatch for Leptospirosis

Genetic Tests for Leptospirosis

Anatomical Context for Leptospirosis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Leptospirosis:

33
Skin, Liver, Kidney, Lung, Whole blood, Heart, Small intestine, T cells, B cells, Fetal liver, Fetal lung

Animal Models for Leptospirosis or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Leptospirosis

Sources:
51PubMed
See all sources

Articles related to Leptospirosis:

(show top 50)    (show all 566)
idTitleAuthorsYear
1
Pathophysiology of leptospirosis. (23481497)
2013
2
Leptospirosis risk increases with changes in species composition of rat populations. (23535996)
2013
3
Leptospirosis in the republic of Korea: historical perspectives, current status and future challenges. (24265962)
2013
4
Severe acute pancreatitis - a serious complication of leptospirosis. (24146692)
2013
5
Serological survey of leptospirosis in livestock in Thailand. (23308397)
2013
6
Leptospirosis--current risk factors connected with human activity and the environment. (23772568)
2013
7
Severe leptospirosis: treatment with intravenous corticosteroids and supportive care. (22980361)
2013
8
Atrial flutter complicating severe leptospirosis: a case report. (23740056)
2013
9
Intracranial hemorrhage in a patient coinfected with dengue and leptospirosis. (24250191)
2013
10
Travel-related leptospirosis: a series of 15 imported cases. (23809072)
2013
11
A prime-boost strategy using the novel vaccine candidate, LemA, protects hamsters against leptospirosis. (23515012)
2013
12
Evaluation of 'white-spotted kidneys' associated with leptospirosis by polymerase chain reaction based LipL32 gene in slaughtered cows. (23327135)
2012
13
Cases distribution of leptospirosis in City of Manaus, State of Amazonas, Brazil, 2000-2010. (23295874)
2012
14
Leptospirosis after typhoon. (22302844)
2012
15
Protective ventilation and alveolar recruitment maneuver in a patient with leptospirosis-induced acute respiratory distress syndrome. (22407052)
2012
16
A field-expedient method for detection of leptospirosis causative agents in rodents. (22815161)
2012
17
Leptospirosis outbreaks in Nicaragua: identifying critical areas and exploring drivers for evidence-based planning. (23202822)
2012
18
Growth response and shedding of Leptospira spp. in urine following vaccination for leptospirosis in young farmed deer. (22175424)
2012
19
Pulmonary manifestations of leptospirosis. (23243349)
2012
20
Accuracy of a dual path platform (DPP) assay for the rapid point-of-care diagnosis of human leptospirosis. (23133686)
2012
21
Interference in diagnostic tests for brucellosis in cattle recently vaccinated against leptospirosis. (22379045)
2012
22
Quantitative polymerase chain reaction: filling the gap for early leptospirosis diagnosis. (22354923)
2012
23
Leptospirosis: a re-emerging infection. (22575986)
2012
24
Sporadic urban leptospirosis. (23882321)
2011
25
Serologic evidence of human leptospirosis in and around Kolkata, India: a clinico-epidemiological study. (22118039)
2011
26
Prevalence and carrier status of leptospirosis in smallholder dairy cattle and peridomestic rodents in Kandy, Sri Lanka. (21284522)
2011
27
2010 ACVIM small animal consensus statement on leptospirosis: diagnosis, epidemiology, treatment, and prevention. (21155890)
2011
28
Potential benefits of plasma exchange by apheresis on the treatment of severe Icteric Leptospirosis: case report and literature review. (21889407)
2011
29
Evaluations of land cover risk factors for canine leptospirosis: 94 cases (2002-2009). (21724280)
2011
30
Urinary shedding of spirochaetes in a dog with acute leptospirosis despite treatment. (21546405)
2011
31
Travel-related leptospirosis in Israel: a nationwide study. (20207873)
2010
32
WITHDRAWN. Antibiotics for treating leptospirosis. (20091518)
2010
33
Incidence of leptospirosis in a select population in Nepal. (20494385)
2010
34
Detection and quantification of leptospires in urine of dogs: a maintenance host for the zoonotic disease leptospirosis. (20559675)
2010
35
Risk factors for clinical leptospirosis from Western Jamaica. (20810831)
2010
36
Parenteral use of recombinant activated factor VII during diffuse alveolar hemorrhage secondary to leptospirosis. (19924396)
2010
37
Leptospirosis distribution related to freshwater habitats in the Vojvodina region (Republic of Serbia). (19911133)
2009
38
Incidence of leptospirosis in Mazandaran Province, north of Iran: a one year survey. (20387749)
2009
39
Lymphopenia is observed regularly in the acute (leptospiraemic) phase but not the immune phase of leptospirosis. (19386339)
2009
40
Evaluation of high performance liquid chromatography purified leptospiral antigen for the diagnosis of leptospirosis. (19934533)
2009
41
Pulmonary involvement and leptospirosis, Greece. (19402988)
2009
42
Acute disseminated encephalomyelitis after leptospirosis. (19433285)
2009
43
Epidemiology of human leptospirosis in Trinidad and Tobago, 1996-2007: a retrospective study. (19679092)
2009
44
Release of granzymes and chemokines in Thai patients with leptospirosis. (17359329)
2007
45
Differential expression of interferon-gamma and interferon-gamma-inducing cytokines in Thai patients with scrub typhus or leptospirosis. (15451469)
2004
46
Evaluation of the clinical utility of a rapid blood test for human leptospirosis. (12007438)
2002
47
Anti-beta2 glycoprotein I and anticardiolipin antibodies in leptospirosis, syphilis and Kala-azar. (11491498)
2001
48
Macroscopic agglutination test for rapid diagnosis of human leptospirosis. (9774553)
1998
49
Seroepidemiologic study of three zoonoses (leptospirosis, Q fever, and tularemia) among trappers in QuAcbec, Canada. (7583933)
1995
50
Leptospirosis with acute acalculous cholecystitis and pancreatitis. (8421147)
1993

Genetic Variations for Leptospirosis

Expression for genes affiliated with Leptospirosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Leptospirosis

Search GEO for disease gene expression data for Leptospirosis.

Pathways for genes affiliated with Leptospirosis

Sources:
54Reactome, 12EMD Millipore, 30KEGG
See all sources

Compounds for genes affiliated with Leptospirosis

Sources:
45Novoseek
See all sources

Compounds related to Leptospirosis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1mannan4510.4KIR2DL2, CD40LG

GO Terms for genes affiliated with Leptospirosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Leptospirosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to membraneGO:01602110.0KIR2DL3, KIR2DL5A, KIR2DL2, KIR2DS2, KIR3DL3, KIR2DS1
2integral to plasma membraneGO:0058879.9CD40LG, KIR2DL3, KIR2DL1, KIR2DS3, KIR3DS1, KIR2DL4
3plasma membraneGO:0058869.7AQP2, PIK3C2A, CD40LG, KIR2DL3, KIR2DL1, KIR2DL5A

Biological processes related to Leptospirosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695510.2KIR2DS5, KIR2DS1, KIR3DS1, KIR2DS2, KIR2DL1, KIR2DL3
2regulation of immune responseGO:0507769.9KIR2DS1, CD40LG, KIR2DL3, KIR2DL1, KIR2DL2, KIR2DS2

Molecular functions related to Leptospirosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:00488810.3KIR2DS1, KIR2DL4, KIR2DS2

Products for genes affiliated with Leptospirosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Leptospirosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet