MCID: LPT001
MIFTS: 57

Leptospirosis

Categories: Rare diseases, Infectious diseases, Skin diseases

Aliases & Classifications for Leptospirosis

MalaCards integrated aliases for Leptospirosis:

Name: Leptospirosis 12 50 56 52 3 42 14 69
Weil Disease 50 42 69
Hemorrhagic Jaundice 50 69
Stuttgart Disease 50 69
Fort Bragg Fever 12 69
Canicola Fever 50 69
Leptospirosis Icterohaemorrhagica 12
Equine Infectious Anemia 69
Icterohemorrhagic Fever 50
Rat Catcher's Yellows 12
Spirochetal Jaundice 12
Canine Leptospirosis 69
Swineherd's Disease 50
Cane-Cutter Fever 50
Nanukayami Fever 12
Rice-Field Fever 50
Weil's Disease 12
Swamp Fever 50
Nanukayami 69
Mud Fever 50

Characteristics:

Orphanet epidemiological data:

56
leptospirosis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 56  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:2297
ICD10 33 A27 A27.0 A27.9
ICD9CM 35 100 100.0 100.9
NCIt 47 C84825
Orphanet 56 ORPHA509
MESH via Orphanet 43 D007922
UMLS via Orphanet 70 C0023364
ICD10 via Orphanet 34 A27.0 A27.8 A27.9

Summaries for Leptospirosis

Disease Ontology : 12 A primary bacterial infectious disease that involves systemic infection, has material basis in Leptospira, which is transmitted_by contact with water, food, or soil containing urine from the infected animals. The infection has symptom jaundice, has symptom chills, has symptom fever, has symptom muscle pain, and has symptom hepatomegaly.

MalaCards based summary : Leptospirosis, also known as weil disease, is related to dengue disease and tularemia. An important gene associated with Leptospirosis is PIK3C2A (Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha), and among its related pathways/superpathways are PEDF Induced Signaling and TGF-Beta Pathway. The drugs Dexamethasone and Antiemetics have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and lung, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and cardiovascular system

CDC : 3 Leptospirosis is a bacterial disease that affects humans and animals. It is caused by bacteria of the genus Leptospira. In humans, it can cause a wide range of symptoms, some of which may be mistaken for other diseases. Some infected persons, however, may have no symptoms at all.

Wikipedia : 72 Leptospirosis is an infection caused by corkscrew-shaped bacteria called Leptospira. Signs and symptoms... more...

Related Diseases for Leptospirosis

Diseases related to Leptospirosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 421)
id Related Disease Score Top Affiliating Genes
1 dengue disease 31.9 IL10 TLR2 TNF
2 tularemia 30.3 CD40LG IL10 TNF
3 hemorrhagic fever with renal syndrome 30.2 CD40LG PIK3C2A
4 toxoplasmosis 30.0 IL6 TNF
5 melioidosis 29.6 IL10 IL6 TLR2 TNF
6 ileocolitis 29.5 CD40LG IL1B TNF
7 uveitis 29.4 CCL2 CD40LG TNF
8 autoimmune hepatitis 28.9 CCL2 CRP IL1B TNF
9 acute pancreatitis 28.7 CCL2 CXCL8 IL1B IL6
10 lymphoma 28.2 CD40LG IL10 IL1B IL6 TNF
11 calcinosis 28.0 CCL2 CD40LG CRP IL6 TNF
12 malaria 26.4 CCL2 CD40LG CRP CXCL8 IL10 IL1B
13 pure autonomic failure 10.9 IL10 TNF
14 acute ackee fruit intoxication 10.8 IL10 TNF
15 moyamoya disease 10.8
16 multiple familial trichoepithelioma 10.8 IL10 TNF
17 lagophthalmos 10.8 IL10 TNF
18 chronic fungal otitis externa 10.8 CRP F2
19 burning mouth syndrome 10.8 F2 TNF
20 type 1 papillary adenoma of the kidney 10.7 IL10 TNF
21 adrenal carcinoma 10.7 F2 PIK3C2A
22 neutrophil-specific granule deficiency 10.7 IL10 TLR2
23 synostosis 10.6 CRP F2
24 endosalpingiosis 10.6 IL10 TNF
25 psychologic dyspareunia 10.6 F2 IL10 TNF
26 subcutaneous mycosis 10.6 CXCL8 SLC9A3
27 tabatznik syndrome 10.6 IL1B TNF
28 moderately severe hemophilia b 10.6 F2 IL10 TNF
29 sternal cleft 10.6 IL1B TNF
30 balkan hemorrhagic fever 10.6 CD40LG IL10
31 mycobacterium malmoense 10.6 CXCL8 TLR2
32 malignant struma ovarii 10.6 IL10 SLC12A1 SLC9A3
33 lymph node palisaded myofibroblastoma 10.6 CXCL8 IL10
34 pulmonary hypertension 10.5 IL1B TNF
35 congenital insensitivity to pain with hyperhidrosis 10.5 CXCL8 IL10
36 rete ovarii adenoma 10.5 F2 PIK3C2A TNF
37 basidiobolomycosis 10.5 CXCL8 IL10 TNF
38 mycobacterium xenopi 10.5 CXCL8 TLR2
39 diabetic angiopathy 10.5 CD40LG IL10
40 tarsal tunnel syndrome 10.5 CXCL8 IL10 TNF
41 hypospadias 10.5 IL10 TLR2 TNF
42 plantar wart 10.5 CXCL8 IL10 TNF
43 fragile x syndrome type 2 10.5 CD40LG F2
44 prothrombin thrombophilia 10.5 IL1B TLR2
45 lockwood feingold syndrome 10.5 CD40LG F2
46 pericardium disease 10.5 IL10 TLR2 TNF
47 small cell lung cancer, adult 10.5 CRP CXCL8
48 trichostrongyloidiasis 10.5 CD40LG PIK3C2A
49 smarca4-deficient sarcoma of thorax 10.5 IL6 TNF
50 acute kidney tubular necrosis 10.5 CD40LG PIK3C2A

Comorbidity relations with Leptospirosis via Phenotypic Disease Network (PDN):


Acute Cystitis Acute Kidney Failure
Chronic Kidney Failure Deficiency Anemia
Familial Atrial Fibrillation Heart Disease

Graphical network of the top 20 diseases related to Leptospirosis:



Diseases related to Leptospirosis

Symptoms & Phenotypes for Leptospirosis

GenomeRNAi Phenotypes related to Leptospirosis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.77 CXCL8 F2 IL10 IL1B TNF AQP1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.77 F2 IL10 IL1B TNF AQP1 CD40LG
3 Decreased ionizing radiation sensitivity GR00232-A-1 9.5 SLC9A3 TNF CD40LG IL10 IL1B PIK3C2A

MGI Mouse Phenotypes related to Leptospirosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.23 IL1B IL6 PIK3C2A SLC12A1 SLC9A3 TLR2
2 homeostasis/metabolism MP:0005376 10.18 TLR2 TNF AQP1 CD40LG CRP F2
3 hematopoietic system MP:0005397 10.13 AQP1 CD40LG F2 IL10 IL1B IL6
4 immune system MP:0005387 10.11 CCL2 CD40LG CRP F2 IL10 IL1B
5 integument MP:0010771 9.92 CD40LG F2 TNF IL10 IL1B IL6
6 nervous system MP:0003631 9.91 AQP1 CD40LG F2 IL10 IL1B IL6
7 renal/urinary system MP:0005367 9.7 AQP1 CD40LG IL6 PIK3C2A SLC12A1 SLC9A3
8 reproductive system MP:0005389 9.56 AQP1 CD40LG F2 IL10 IL6 SLC12A1
9 skeleton MP:0005390 9.28 AQP1 CD40LG F2 IL10 IL1B IL6

Drugs & Therapeutics for Leptospirosis

Drugs for Leptospirosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 2, Phase 3 50-02-2 5743
2 Antiemetics Phase 2, Phase 3
3 Anti-Inflammatory Agents Phase 2, Phase 3
4 Antineoplastic Agents, Hormonal Phase 2, Phase 3
5 Arginine Vasopressin Phase 2, Phase 3
6 Autonomic Agents Phase 2, Phase 3
7 BB 1101 Phase 2, Phase 3
8 Coagulants Phase 2, Phase 3
9 Deamino Arginine Vasopressin Phase 2, Phase 3
10 Dexamethasone acetate Phase 2, Phase 3 1177-87-3
11 Gastrointestinal Agents Phase 2, Phase 3
12 glucocorticoids Phase 2, Phase 3
13 Hemostatics Phase 2, Phase 3
14 HIV Protease Inhibitors Phase 2, Phase 3
15 Hormone Antagonists Phase 2, Phase 3
16 Hormones Phase 2, Phase 3
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
18 Natriuretic Agents Phase 2, Phase 3
19 Peripheral Nervous System Agents Phase 2, Phase 3
20
protease inhibitors Phase 2, Phase 3
21 Vasopressins Phase 2, Phase 3
22 arginine Nutraceutical Phase 2, Phase 3
23
Albendazole Approved, Vet_approved 54965-21-8 2082
24
Ivermectin Approved, Vet_approved 70288-86-7 6474909 46936176
25
Mebendazole Approved, Vet_approved 31431-39-7 4030
26
Ethanol Approved 64-17-5 702
27
Doxycycline Approved, Investigational, Vet_approved Early Phase 1 564-25-0 54671203
28
Tetracycline Approved, Vet_approved Early Phase 1 60-54-8 5353990
29 Antibodies
30 Immunoglobulins
31 Anti-Bacterial Agents Early Phase 1
32 Antibiotics, Antitubercular
33 Anti-Infective Agents Early Phase 1
34 Antimalarials Early Phase 1
35 Antiparasitic Agents Early Phase 1
36 Antiprotozoal Agents Early Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Desmopressin and Dexamethasone Adjunctive Treatment for Leptospirosis Terminated NCT00592566 Phase 2, Phase 3 Dexamethasone, desmopressin
2 The Sero-Prevalence and Genetic Study for the Infectious Diseases and Metabolic Syndrome in Solomon Islands Completed NCT01080989
3 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases In Patients With Persistent Fever in Cambodia, Nepal, Democratic Republic of the Congo and Sudan (NIDIAG-Fever) Completed NCT01766830
4 Study of Decreasing Kinetics of the Leptospiremia During Antibiotic Treatment of Leptospirosis in Martinique Recruiting NCT02000635
5 French West Indies Leptospirosis Study Recruiting NCT01607047
6 Immune Response After Leptospirosis Infection Not yet recruiting NCT02898519
7 Scrub Typhus RDT Study Not yet recruiting NCT03269266
8 Oral Doxycycline for the Prevention of Syphilis in Men Who Have Sex With Men Not yet recruiting NCT02864550 Early Phase 1 Doxycycline

Search NIH Clinical Center for Leptospirosis

Cochrane evidence based reviews: leptospirosis

Genetic Tests for Leptospirosis

Anatomical Context for Leptospirosis

MalaCards organs/tissues related to Leptospirosis:

39
Kidney, Testes, Lung, Skin, T Cells, Liver, Heart

Publications for Leptospirosis

Articles related to Leptospirosis:

(show top 50) (show all 717)
id Title Authors Year
1
Leptospirosis Renal Disease: Emerging Culprit of Chronic Kidney Disease Unknown Etiology. ( 28926845 )
2017
2
A process for developing multisectoral strategies for zoonoses: the case of leptospirosis in Fiji. ( 28830472 )
2017
3
Efficacy of a new recrystallized enrofloxacin hydrochloride-dihydrate against leptospirosis in a hamster model. ( 28874381 )
2017
4
Molecular detection of leptospirosis and melioidosis co-infection: A case report. ( 28330585 )
2017
5
DNA vaccines against leptospirosis: A literature review. ( 28882437 )
2017
6
Seroepidemiology of Leptospirosis among febrile patients in a rapidly growing suburban slum and a flood vulnerable rural district in Mozambique, 2012-2014: Implication for the management of fever. ( 28893674 )
2017
7
Leptospirosis Cases in the Tokyo Metropolitan Area, Japan. ( 28890513 )
2017
8
A systematic review of leptospirosis on dogs, pigs, and horses in Latin America. ( 27909915 )
2017
9
New trends in human and animal leptospirosis in Croatia, 2009-2014. ( 28063871 )
2017
10
Low-dose norfloxacin and ciprofloxacin therapy worsen leptospirosis in hamster. ( 27894961 )
2017
11
Rapid, actionable diagnosis of urban epidemic leptospirosis using a pathogenic Leptospira lipL32-based real-time PCR assay. ( 28915243 )
2017
12
Leptospirosis: Molecular trial path and immunopathogenesis correlated with dengue, malaria and mimetic hemorrhagic infections. ( 28823908 )
2017
13
Correction: Cathelicidin Insufficiency in Patients with Fatal Leptospirosis. ( 28950012 )
2017
14
Severe leptospirosis in Morocco: comparative data from the Amazonian area. ( 28875288 )
2017
15
Comparing antibiotic treatment for leptospirosis using network meta-analysis: a tutorial. ( 28056834 )
2017
16
Epidemiological and clinical features of leptospirosis in a highly endemic area over three time periods. ( 28857412 )
2017
17
Platelet dysfunction contributes to bleeding complications in patients with probable leptospirosis. ( 28934202 )
2017
18
The influence of climatic factors on the development of hemorrhagic fever with renal syndrome and leptospirosis during the peak season in Korea: an ecologic study. ( 28592316 )
2017
19
Leptospirosis on captive wild animals in Latin America. ( 28804053 )
2017
20
Human leptospirosis in Seychelles: A prospective study confirms the heavy burden of the disease but suggests that rats are not the main reservoir. ( 28846678 )
2017
21
Evaluation of clinical, laboratory, imaging findings and outcome in 99 dogs with leptospirosis. ( 28804909 )
2017
22
Sero-epidemiology study of leptospirosis in febrile patients from Terai region of Nepal. ( 28923024 )
2017
23
A Case of Kawasaki Disease With Concomitant Leptospirosis. ( 28804750 )
2017
24
Varied presentations of leptospirosis: experience from a tertiary care hospital in north India. ( 28092222 )
2017
25
Leptospirosis in three workers on a dairy farm with unvaccinated cattle. ( 28934773 )
2017
26
Multi-organ failure, weeks after being exposed to murky water - rule out leptospirosis. ( 28808510 )
2017
27
Seroprevalence of Leptospirosis, Brucellosis, and Q Fever in a Wild Red Deer (Cervus elaphus) Population Kept in a Fenced Reserve in Absence of Contact with Livestock. ( 28873022 )
2017
28
Risk factors for leptospirosis seropositivity in slaughterhouse workers in western Kenya. ( 27913579 )
2016
29
LEPTOSPIROSIS INCIDENCE AND MORTALITY IN MALAYSIA. ( 27405126 )
2016
30
Serological survey of leptospirosis among different groups in western Iran. ( 27589994 )
2016
31
Snowflakes in August: Leptospirosis Hemorrhagic Pneumonitis. ( 27542609 )
2016
32
Molecular diagnostics for human leptospirosis. ( 27537829 )
2016
33
Utility of modified Faine's criteria in diagnosis of leptospirosis. ( 27554098 )
2016
34
A case-control study of epidemiological factors associated with leptospirosis in South Gujarat region. ( 27531691 )
2016
35
Chronic kidney disease of uncertain etiology in Sri Lanka: Are leptospirosis and Hantaviral infection likely causes? ( 27142134 )
2016
36
TLR2 agonist Pam3CSK4 alleviates the pathology of leptospirosis in hamster. ( 27620721 )
2016
37
Hemodiafiltration Decreases Serum Levels of Inflammatory Mediators in Severe Leptospirosis: A Prospective Study. ( 27487001 )
2016
38
Estimating the Burden of Leptospirosis among Febrile Subjects Aged below 20 Years in Kampong Cham Communities, Cambodia, 2007-2009. ( 27043016 )
2016
39
Characterization of leptospirosis among dogs in Oregon, 2007-2011. ( 27031417 )
2016
40
Paediatric leptospirosis: A population based case-control study from Chennai, India. ( 27080780 )
2016
41
Arrhythmias in leptospirosis-associated acute kidney injury: a case series. ( 28041768 )
2016
42
Cathelicidin Insufficiency in Patients with Fatal Leptospirosis. ( 27812211 )
2016
43
Genetic diversity of Leptospira in northwestern Colombia: first report of Leptospira santarosai as a recognised leptospirosis agent. ( 27982303 )
2016
44
Correction: Epidemiology of Leptospirosis in Africa: A Systematic Review of a Neglected Zoonosis and a Paradigm for 'One Health' in Africa. ( 26967907 )
2016
45
Serological surveillance of Leptospirosis in Italy: twoa89year national data (2010a892011). ( 27393874 )
2016
46
Mapping risk of leptospirosis in China using environmental and socioeconomic data. ( 27448599 )
2016
47
Cytokine and Chemokine Expression in Kidneys during Chronic Leptospirosis in Reservoir and Susceptible Animal Models. ( 27219334 )
2016
48
Leptospirosis: A Public Health Story Encircling the Globe. ( 27161412 )
2016
49
Saccharomyces boulardii improves humoral immune response to DNA vaccines against leptospirosis. ( 28008823 )
2016
50
Fatal leptospirosis and chikungunya co-infection: Do not forget leptospirosis during chikungunya outbreaks. ( 27413690 )
2016

Variations for Leptospirosis

Expression for Leptospirosis

Search GEO for disease gene expression data for Leptospirosis.

Pathways for Leptospirosis

Pathways related to Leptospirosis according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.64 CCL2 CD40LG CXCL8 F2 IL10 IL1B
2
Show member pathways
13.5 CCL2 CXCL8 F2 IL10 IL1B IL6
3
Show member pathways
13.42 CCL2 CD40LG CXCL8 IL10 IL1B IL6
4
Show member pathways
13.36 CCL2 CD40LG CXCL8 IL10 IL1B IL6
5
Show member pathways
13.3 CCL2 CD40LG CXCL8 IL10 IL1B IL6
6
Show member pathways
13 CCL2 CXCL8 IL1B IL6 TLR2 TNF
7
Show member pathways
12.9 CCL2 CXCL8 IL10 IL1B IL6 TLR2
8
Show member pathways
12.88 CD40LG CXCL8 IL10 IL1B IL6 TNF
9
Show member pathways
12.82 CCL2 CXCL8 IL1B IL6 TLR2 TNF
10
Show member pathways
12.71 CD40LG IL1B IL6 TLR2 TNF
11
Show member pathways
12.64 CCL2 F2 IL10 IL1B IL6 TNF
12
Show member pathways
12.62 IL10 IL1B IL6 TLR2 TNF
13 12.59 CCL2 CD40LG IL10 IL1B TLR2 TNF
14
Show member pathways
12.48 CD40LG IL10 IL1B IL6 TNF
15
Show member pathways
12.37 CCL2 CXCL8 IL1B IL6 TLR2 TNF
16
Show member pathways
12.31 CD40LG IL10 IL1B TLR2 TNF
17
Show member pathways
12.29 CXCL8 IL1B IL6 TNF
18 12.29 IL10 IL1B IL6 TLR2 TNF
19
Show member pathways
12.25 CXCL8 IL1B IL6 TLR2 TNF
20
Show member pathways
12.22 CXCL8 IL10 IL1B IL6 TNF
21 12.18 CXCL8 IL10 IL1B IL6 SLC9A3 TNF
22
Show member pathways
12.02 IL10 IL1B IL6 TLR2 TNF
23 12.01 CCL2 IL1B IL6 TNF
24
Show member pathways
11.99 IL1B PIK3C2A TLR2
25 11.97 IL10 IL6 TNF
26 11.96 CCL2 CXCL8 IL1B IL6 TNF
27 11.96 AQP1 CCL2 CXCL8 IL1B IL6 TNF
28 11.94 CD40LG CXCL8 IL1B TNF
29 11.92 CXCL8 IL1B IL6
30
Show member pathways
11.9 IL1B IL6 TLR2
31 11.9 CCL2 CXCL8 IL10 IL1B IL6 TNF
32 11.88 IL1B IL6 TNF
33 11.83 IL10 IL1B IL6 TNF
34 11.82 CXCL8 IL1B IL6
35 11.82 CXCL8 IL10 IL1B IL6 TNF
36 11.79 IL10 IL1B TNF
37 11.78 CXCL8 IL10 IL1B IL6 TLR2 TNF
38
Show member pathways
11.76 CD40LG CXCL8 TNF
39 11.75 CD40LG IL10 IL6 TLR2 TNF
40 11.69 CCL2 CXCL8 IL1B IL6 TLR2 TNF
41 11.67 CCL2 CXCL8 IL1B IL6 TNF
42
Show member pathways
11.65 CD40LG CXCL8 IL1B IL6 TNF
43 11.6 CCL2 IL1B TLR2 TNF
44 11.57 CXCL8 IL1B IL6 TLR2 TNF
45 11.52 IL1B IL6 TNF
46 11.45 IL10 IL1B IL6 TNF
47 11.44 IL10 IL1B IL6 TNF
48 11.39 CCL2 CXCL8 IL6
49 11.36 IL1B IL6 TNF
50 11.35 IL10 IL1B IL6 TNF

GO Terms for Leptospirosis

Cellular components related to Leptospirosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 CCL2 CD40LG CRP CXCL8 F2 IL10
2 external side of plasma membrane GO:0009897 9.46 CD40LG F2 IL6 TNF
3 extracellular space GO:0005615 9.28 CCL2 CD40LG CRP CXCL8 F2 IL10

Biological processes related to Leptospirosis according to GeneCards Suite gene sharing:

(show top 50) (show all 53)
id Name GO ID Score Top Affiliating Genes
1 cellular response to tumor necrosis factor GO:0071356 9.89 CCL2 CXCL8 IL6
2 positive regulation of angiogenesis GO:0045766 9.89 AQP1 CXCL8 IL1B
3 platelet activation GO:0030168 9.88 CD40LG F2 IL6
4 response to lipopolysaccharide GO:0032496 9.88 CCL2 IL10 IL1B IL6 TLR2
5 cellular response to organic cyclic compound GO:0071407 9.86 CCL2 IL1B TNF
6 response to wounding GO:0009611 9.85 CCL2 F2 IL6
7 cellular response to interleukin-1 GO:0071347 9.85 CCL2 CXCL8 IL6
8 response to insulin GO:0032868 9.85 IL10 IL6 TLR2
9 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.85 IL10 IL1B IL6 TNF
10 neutrophil chemotaxis GO:0030593 9.84 CCL2 CXCL8 IL1B
11 defense response to Gram-positive bacterium GO:0050830 9.84 CRP IL6 TLR2 TNF
12 positive regulation of T cell proliferation GO:0042102 9.83 CD40LG IL1B IL6
13 humoral immune response GO:0006959 9.82 CCL2 IL6 TNF
14 response to glucocorticoid GO:0051384 9.8 CCL2 IL10 IL6 TNF
15 positive regulation of nitric oxide biosynthetic process GO:0045429 9.79 IL1B IL6 TNF
16 cellular response to estradiol stimulus GO:0071392 9.78 CCL2 IL10 IL6
17 acute-phase response GO:0006953 9.76 CRP F2 IL6
18 cellular response to dexamethasone stimulus GO:0071549 9.75 AQP1 CCL2 IL6
19 protein kinase B signaling GO:0043491 9.74 CCL2 IL1B TNF
20 positive regulation of interleukin-8 production GO:0032757 9.73 IL1B TLR2 TNF
21 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.72 CD40LG IL1B IL6 TLR2 TNF
22 negative regulation of lipid catabolic process GO:0050995 9.71 IL1B TNF
23 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.71 IL1B TNF
24 negative regulation of growth of symbiont in host GO:0044130 9.7 IL10 TNF
25 cellular response to hepatocyte growth factor stimulus GO:0035729 9.7 IL10 IL6
26 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.7 IL1B TNF
27 positive regulation of NF-kappaB import into nucleus GO:0042346 9.7 IL1B TLR2 TNF
28 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.69 CCL2 TLR2
29 cellular homeostasis GO:0019725 9.69 AQP1 CCL2
30 PERK-mediated unfolded protein response GO:0036499 9.69 CCL2 CXCL8
31 positive regulation of chemokine production GO:0032722 9.69 IL6 TLR2 TNF
32 positive regulation of chemokine biosynthetic process GO:0045080 9.68 IL1B TNF
33 endothelial cell apoptotic process GO:0072577 9.67 IL10 TNF
34 positive regulation of interleukin-6 production GO:0032755 9.67 IL1B IL6 TLR2 TNF
35 regulation of establishment of endothelial barrier GO:1903140 9.66 IL1B TNF
36 negative regulation of cytokine secretion involved in immune response GO:0002740 9.65 IL10 TNF
37 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.65 IL6 TNF
38 cellular response to lipopolysaccharide GO:0071222 9.65 CCL2 CXCL8 IL10 IL6 TNF
39 positive regulation of fever generation GO:0031622 9.64 IL1B TNF
40 regulation of immunoglobulin secretion GO:0051023 9.64 CD40LG TNF
41 sequestering of triglyceride GO:0030730 9.63 IL1B TNF
42 response to molecule of bacterial origin GO:0002237 9.63 CXCL8 IL10 TLR2
43 regulation of vascular endothelial growth factor production GO:0010574 9.62 CCL2 IL6
44 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.61 IL10 IL1B TNF
45 receptor biosynthetic process GO:0032800 9.6 IL10 TNF
46 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.59 IL1B TNF
47 negative regulation of lipid storage GO:0010888 9.58 CRP IL6 TNF
48 immune response GO:0006955 9.56 CCL2 CD40LG CXCL8 IL10 IL1B IL6
49 lipopolysaccharide-mediated signaling pathway GO:0031663 9.46 CCL2 IL1B TLR2 TNF
50 inflammatory response GO:0006954 9.28 CCL2 CD40LG CRP CXCL8 IL10 IL1B

Molecular functions related to Leptospirosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.17 CCL2 CD40LG CXCL8 IL10 IL1B IL6

Sources for Leptospirosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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