MCID: LKM002
MIFTS: 70

Leukemia malady

Cancer category

Summaries for Leukemia

Sources:
8Disease Ontology, 34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Leukemia is cancer of the white blood cells. white blood cells help your body fight infection. your blood cells form in your bone marrow. in leukemia, the bone marrow produces abnormal white blood cells. these cells crowd out the healthy blood cells, making it hard for blood to do its work. there are different types of leukemia, including acute lymphocytic leukemia acute myeloid leukemia chronic lymphocytic leukemia chronic myeloid leukemia leukemia can develop quickly or slowly. chronic leukemia grows slowly. in acute leukemia, the cells are very abnormal and their number increases rapidly. adults can get either type; childen with leukemia most often have an acute type. some leukemias can often be cured. other types are hard to cure, but you can often control them. treatments may include chemotherapy, radiation and stem cell transplantation. even if symptoms disappear, you might need therapy to prevent a relapse. nih: national cancer institute

MalaCards: Leukemia is related to acute leukemia and acute myeloid leukemia. An important gene associated with Leukemia is RUNX1 (runt-related transcription factor 1), and among its related pathways are Transcriptional misregulation in cancer and Pathways in cancer. The drugs irinotecan and irinotecan hydrochloride and the compounds tyrosine and zinc have been mentioned in the context of this disorder. Related mouse phenotypes are cellular and immune system.

Disease Ontology:8 A cancer that affects the blood or bone marrow characterized by an abnormal proliferation of blood cells.

Wikipedia:64 Leukemia (American English) or leukaemia (British English) is a type of cancer of the blood or bone... more...

Aliases & Classifications for Leukemia

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 31LifeMap Discovery™, 61UMLS, 27ICD9CM, 57SNOMED-CT, 40NCIt, 35MeSH, 25ICD10
See all sources

Related Diseases for Leukemia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1057)
idRelated DiseaseScoreTop Affiliating Genes
1acute leukemia32.5RUNX1, PML, MLF1, MPL, LYL1, ZBTB16
2acute myeloid leukemia32.1MLF1, PICALM, ARHGEF12, RUNX1, SH3GL1
3chronic myeloid leukemia31.8PML, RUNX1, MPL, ABL1, KMT2A, THPO
4acute promyelocytic leukemia31.7ZBTB16, RUNX1, KMT2A, PML
5acute lymphocytic leukemia31.6ABL1, KMT2A, THPO, RUNX1, MME, MPL
6acute lymphoblastic leukemia, childhood31.6KMT2A, ABL1, RUNX1, TLX1, MME
7chronic myelomonocytic leukemia31.5MPL, RUNX1
8acute myelomonocytic leukemia31.4RUNX1, KMT2A
9b-cell chronic lymphocytic leukemia31.2BCL3, KMT2A, TRIM13
10acute myeloid leukemia, adult31.2RUNX1, KMT2A
11myelodysplastic syndromes31.1THPO, KMT2A, MLF1, MPL, RUNX1, ABL1
12megakaryocytic leukemia31.1THPO, KMT2A, MKL1, RUNX1
13refractory anemia30.8THPO, MPL, RUNX1
14myeloproliferative disorder30.8RUNX1, MPL, ABL1, KMT2A, THPO
15precursor t-cell acute lymphoblastic leukemia30.7TLX1, RUNX1, PICALM, ABL1, LYL1, KMT2A
16precursor b-cell acute lymphoblastic leukemia30.5MME, ABL1, KMT2A
17polycythemia vera30.5MPL, THPO
18thrombocytosis30.4MPL, THPO
19adenocarcinoma30.4MME, KMT2A
20burkitt's lymphoma30.4RUNX1, MME, ABL1
21pancytopenia30.4KMT2A, THPO, MPL
22follicular lymphoma30.4KMT2A, BCL3, MME
23splenomegaly30.3THPO, MPL
24lymphoma, diffuse large cell30.3MME, PICALM
25autoimmune thrombocytopenic purpura29.8MPL, THPO
26t-cell leukemia11.5
27acute t cell leukemia11.2
28leukemia, t-cell, chronic11.0
29adult t-cell leukemia11.0
30plasma cell leukemia10.9
31adult lymphoma10.9
32acute monocytic leukemia10.9
33leukemia, b-cell, chronic10.9
34leukemia/lymphoma, t-cell10.9
35juvenile myelomonocytic leukemia10.8
36large granular lymphocyte leukemia10.8
37lymphoid leukemia10.8
38lymphoblastic lymphoma10.8
39hematopoietic stem cell transplantation10.8
40central nervous system leukemia10.7
41natural killer cell leukemia10.7
42n syndrome10.7
43chronic neutrophilic leukemia10.7
44adult acute lymphocytic leukemia10.7
45mast-cell leukemia10.6
46wilms tumor10.6
47graft versus host disease10.6
48acute myeloid leukemia, childhood10.6
49acute biphenotypic leukemia10.6
50t-cell prolymphocytic leukemia10.6

Graphical network of the top 20 diseases related to Leukemia:



Diseases related to leukemia

Clinical Features for Leukemia

Drugs & Therapeutics for Leukemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Leukemia

Drug clinical trials:

Search ClinicalTrials for Leukemia

Search NIH Clinical Center for Leukemia

Search CenterWatch for Leukemia

Inferred drug relations via UMLS61/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Leukemia cell therapies at LifeMap Discovery.

Genetic Tests for Leukemia

Anatomical Context for Leukemia

Animal Models for Leukemia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Leukemia

Sources:
51PubMed
See all sources

Articles related to Leukemia:

(show top 50)    (show all 24004)
idTitleAuthorsYear
1
Expanding clinical trial networks in pediatric acute lymphoblastic leukemia. (24344213)
2014
2
Diet, physical activity, and body composition changes during the first year of treatment for childhood acute leukemia and lymphoma. (23211695)
2013
3
Phase 2 study of azacytidine plus sorafenib in patients with acute myeloid leukemia and FLT-3 internal tandem duplication mutation. (23613521)
2013
4
An effective reinduction regimen for first relapse of adult acute lymphoblastic leukemia. (24135867)
2013
5
Initial absolute lymphocyte count as a prognostic factor for outcome in acute myeloid leukemia. (23786457)
2013
6
Peripheral blood stem cell transplantation from human leukocyte antigen-matched sibling donors and unrelated donors in acute myeloid leukemia patients. (23816761)
2013
7
Gene expression of BAALC, CDKN1B, ERG, and MN1 adds independent prognostic information to cytogenetics and molecular mutations in adult acute myeloid leukemia. (22072540)
2012
8
Reduced-intensity conditioning transplantation in acute leukemia: the effect of source of unrelated donor stem cells on outcomes. (22496153)
2012
9
The hematopoietic growth factors in acute leukemia: a European perspective. (21052965)
2011
10
Vinblastine sensitizes leukemia cells to cyclin-dependent kinase inhibitors, inducing acute cell cycle phase-independent apoptosis. (21768777)
2011
11
ider(17)(q10)t(15;17) associated with relapse and poor prognosis in a pediatric patient with acute promyelocytic leukemia. (20682396)
2010
12
Rapid flow cytometric detection of aberrant cytoplasmic localization of nucleophosmin (NPMc) indicating mutant NPM1 gene in acute myeloid leukemia. (20724983)
2010
13
Does SPRED1 contribute to leukemogenesis in juvenile myelomonocytic leukemia (JMML)? (20339110)
2010
14
The candidate immunotherapeutical target, the receptor for hyaluronic acid-mediated motility, is associated with proliferation and shows prognostic value in B-cell chronic lymphocytic leukemia. (19092852)
2009
15
Inhibitory effect of lentiviral vector-mediated SHIP gene transfection on proliferation of leukemia K562 cells and PI3K/Akt pathway regulation]. (19622295)
2009
16
CD38/CD31, the CCL3 and CCL4 chemokines, and CD49d/vascular cell adhesion molecule-1 are interchained by sequential events sustaining chronic lymphocytic leukemia cell survival. (19383907)
2009
17
Molecular diagnostics in acute leukemias. (19817644)
2009
18
Immunosuppressive properties of mesenchymal stem cells derived from bone marrow of patients with chronic myeloid leukemia. (18821219)
2008
19
Diabetic ketoacidosis during therapy for pediatric acute lymphoblastic leukemia. (18266226)
2008
20
FDA drug approval summary: nelarabine (Arranon) for the treatment of T-cell lymphoblastic leukemia/lymphoma. (18586926)
2008
21
Consolidation and maintenance immunotherapy with rituximab improve clinical outcome in patients with B-cell chronic lymphocytic leukemia. (17999417)
2008
22
Disseminated intravascular coagulation in acute leukemia at presentation and during induction therapy. (17636191)
2007
23
Childhood leukemia in the vicinity of the Geesthacht nuclear establishments near Hamburg, Germany. (17589605)
2007
24
Abnormal expression of PDCD5 in the bone marrow cells of adult acute myeloid leukemia]. (17605845)
2007
25
Avascular necrosis of the femoral head as the first manifestation of acute lymphoblastic leukemia. (16502568)
2006
26
Donor cell-derived acute myeloblastic leukemia after allogeneic peripheral blood hematopoietic stem cell transplantation for juvenile myelomonocytic leukemia. (17114967)
2006
27
Topics in pediatric leukemia--Fanconi's anemia: new insights. (16369402)
2005
28
The Moloney murine leukemia virus repressor binding site represses expression in murine and human hematopoietic stem cells. (12915559)
2003
29
Hypermethylation of the spleen tyrosine kinase promoter in T-lineage acute lymphoblastic leukemia. (12717427)
2003
30
The chemokine receptor CCR7 and alpha4 integrin are important for migration of chronic lymphocytic leukemia cells into lymph nodes. (11929789)
2002
31
Accumulation of somatic mutations in proliferating T cell clones from children treated for leukemia. (11753611)
2001
32
Acute lymphoblastic leukemia and urticaria pigmentosa in an infant. (10797364)
2000
33
Hematological and cytogenetic response of interferon alpha 2b alone and combined interferon alpha plus cytarabine as a first-line treatment in chronic myeloid leukemia. (10985480)
2000
34
Morphological and cytogenetic changes in therapy-related leukemia developed in a t(8;21)-acute myeloid leukemia (M2) patient: sequential cytogenetic and molecular analyses. (10905055)
2000
35
Purified group X secretory phospholipase A(2) induced prominent release of arachidonic acid from human myeloid leukemia cells. (10567392)
1999
36
Expression of leukemia inhibitory factor by cartilage-forming tumors of bone: an immunohistochemical study. (10221849)
1999
37
Analysis of potential phosphorylation sites in human T cell leukemia virus type 1 Tax. (10343169)
1999
38
Cytogenetics and molecular genetics of childhood leukemia. (10641030)
1999
39
Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults. (10536004)
1999
40
Resistance to apoptosis correlates with a highly proliferative phenotype and loss of Fas and CPP32 (caspase-3) expression in human leukemia cells. (9455811)
1998
41
Ricin fusion toxin targeted to the human granulocyte-macrophage colony stimulating factor receptor is selectively toxic to acute myeloid leukemia cells. (9301690)
1997
42
Adult T-cell leukemia/lymphoma with features of CD30-positive anaplastic large cell lymphoma--a case report. (9288638)
1997
43
Identification and characterization of TF1(phox), a DNA-binding protein that increases expression of gp91(phox) in PLB985 myeloid leukemia cells. (9083071)
1997
44
Transactivation of parathyroid hormone-related protein gene expression by human T-cell leukemia virus type I tax. (8599987)
1996
45
AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. (8565077)
1996
46
Expression of N-CAM (CD56) on acute leukemia cells: relationship with disease characteristics and outcome. (8535222)
1995
47
Acute lymphocytic leukemia and psychosis: treatment with electroconvulsive therapy. (8646273)
1995
48
Multifactorial resistance to 5,10-dideazatetrahydrofolic acid in cell lines derived from human lymphoblastic leukemia CCRF-CEM. (7834626)
1995
49
Sterile transcription of immunoglobulin/T-cell receptor genes and other evidence of early lymphoid differentiation in acute myelogenous leukemia. (8371592)
1993
50
Characterization of the defect in a variant of HL-60 promyelocytic leukemia cells with reduced transferrin receptor expression. (1546369)
1992

Genetic Variations for Leukemia

Expression for genes affiliated with Leukemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Leukemia

Search GEO for disease gene expression data for Leukemia.

Pathways for genes affiliated with Leukemia

Sources:
30KEGG, 52QIAGEN, 54Reactome
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Pathways related to Leukemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
112.2LYL1, PML, RUNX1, TLX1, MLF1, ZBTB16
211.5PML, ABL1, ZBTB16, RUNX1
3
Hide members
11.2RUNX1, PML, ZBTB16
411.2ABL2, ABL1, ARHGEF12
511.2ARHGEF12, ABL1, ABL2
611.0ABL2, ABL1

Compounds for genes affiliated with Leukemia

Sources:
45Novoseek, 24HMDB, 50PharmGKB, 11DrugBank, 60Tocris Bioscience
See all sources

Compounds related to Leukemia according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1tyrosine4513.5TLX1, ARHGEF12, MPL, ZBTB16, MME, ABL1
2zinc45 2414.0MPL, KMT2A, ABL1, MME, ZBTB16, KAT6B
3retinoic acid45 2413.7PML, THPO, KMT2A, ABL2, RUNX1, ZBTB16
4oligonucleotide4512.1KMT2A, THPO, ABL1, ARHGEF12, TLX1, RUNX1
5h2o24511.6PML, MME, THPO, ABL2, ABL1
6imatinib45 50 1113.6RUNX1, THPO, ABL2, ABL1
7etoposide45 50 60 1114.6THPO, RUNX1, PML, KMT2A
8actinomycin d4511.5PML, MME, KMT2A, THPO
9af 104511.5PICALM, KMT2A, TLX1
10megapoietin4511.2THPO, MPL
11anagrelide45 1112.0THPO, MPL
12cytarabine45 50 1112.9ABL1, THPO, MME

GO Terms for genes affiliated with Leukemia

Sources:
16Gene Ontology
See all sources

Cellular components related to Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563413.5LYL1, RUNX1, TLX1, KAT6B, PICALM, MLF1

Biological processes related to Leukemia according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1transcription, DNA-dependentGO:00635112.7MLF1, MKL1, ZBTB16, KAT6B, RUNX1, PML
2positive regulation of transcription, DNA-dependentGO:04589312.5KAT6B, LYL1, RUNX1, BCL3, KMT2A, ZBTB16
3myeloid cell differentiationGO:03009911.8ZBTB16, RUNX1, PML, THPO
4central nervous system developmentGO:00741711.8ZBTB16, TLX1, RUNX1, SH3GL1
5regulation of endocytosisGO:03010011.5PICALM, ABL1, ABL2
6hemopoiesisGO:03009711.5ZBTB16, PICALM, RUNX1
7positive regulation of transcription from RNA polymerase II promoterGO:04594411.4RUNX1, TLX1, KMT2A, BCL3, MKL1
8myeloid progenitor cell differentiationGO:00231811.2MLF1, RUNX1
9protein complex assemblyGO:00646111.2KMT2A, PICALM, PML
10positive regulation of oxidoreductase activityGO:05135311.2ABL2, ABL1
11regulation of actin cytoskeleton reorganizationGO:200024911.2ABL2, ABL1
12maintenance of protein location in nucleusGO:05145711.1PML, BCL3
13regulation of cell motilityGO:200014511.1ABL1, ABL2
14definitive hemopoiesisGO:06021611.0LYL1, RUNX1
15embryonic hemopoiesisGO:03516211.0RUNX1, KMT2A
16regulation of autophagyGO:01050610.9ABL2, ABL1

Molecular functions related to Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551514.7PML, ABL1, MME, MKL1, TRIM13, SH3GL1
2DNA bindingGO:00367712.5BCL3, ABL1, ZBTB16, MLF1, KAT6B, RUNX1
3actin monomer bindingGO:00378510.9MKL1, ABL1, ABL2

Products for genes affiliated with Leukemia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Leukemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet