MCID: LKM002
MIFTS: 79

Leukemia malady

Cancer diseases category

Summaries for Leukemia

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Leukemia is cancer of the white blood cells. white blood cells help your body fight infection. your blood cells form in your bone marrow. in leukemia, the bone marrow produces abnormal white blood cells. these cells crowd out the healthy blood cells, making it hard for blood to do its work. there are different types of leukemia, including acute lymphocytic leukemia acute myeloid leukemia chronic lymphocytic leukemia chronic myeloid leukemia leukemia can develop quickly or slowly. chronic leukemia grows slowly. in acute leukemia, the cells are very abnormal and their number increases rapidly. adults can get either type; childen with leukemia most often have an acute type. some leukemias can often be cured. other types are hard to cure, but you can often control them. treatments may include chemotherapy, radiation and stem cell transplantation. even if symptoms disappear, you might need therapy to prevent a relapse. nih: national cancer institute

MalaCards: Leukemia is related to acute leukemia and myeloid leukemia. An important gene associated with Leukemia is RUNX1 (runt-related transcription factor 1), and among its related pathways are Transcriptional misregulation in cancer and Pathways in cancer. The drugs cytarabine and isotretinoin and the compounds tyrosine and zinc have been mentioned in the context of this disorder. Affiliated tissues include myeloid, t cells and b cells, and related mouse phenotypes are cellular and immune system.

Disease Ontology:8 A cancer that affects the blood or bone marrow characterized by an abnormal proliferation of blood cells.

Wikipedia:63 Leukemia (American English) or leukaemia (British English) is a type of cancer of the blood or bone... more...

Aliases & Classifications for Leukemia

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8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 27ICD9CM, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Related Diseases for Leukemia

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17GeneCards, 18GeneDecks
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Diseases in the Leukemia family:

Subacute Leukemia Acute Leukemia

Diseases related to Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1050)
idRelated DiseaseScoreTop Affiliating Genes
1acute leukemia32.5RUNX1, MLF1, MPL, ZBTB16, ABL1, KMT2A
2myeloid leukemia32.2RUNX1, PICALM, MLF1, MPL, ABL1, KMT2A
3acute myeloid leukemia32.1RUNX1, ARHGEF12, PICALM, MLF1, SH3GL1
4lymphoblastic leukemia32.0TLX1
5chronic lymphocytic leukemia32.0BCL3, THPO, KMT2A, ABL1
6chronic myeloid leukemia31.8PML, RUNX1, MPL, ABL1, KMT2A, THPO
7acute lymphocytic leukemia31.6PML, RUNX1, PICALM, MPL, MME, ABL1
8monocytic leukemia31.5RUNX1, KAT6B, KMT2A
9megakaryocytic leukemia31.1THPO, KMT2A, MKL1, RUNX1
10myelofibrosis30.8MPL, THPO
11breast cancer30.8PML, RUNX1, MME, ABL1, KMT2A, THPO
12non-hodgkin lymphoma30.7PML, ZBTB16, KMT2A, BCL3
13acute promyelocytic leukemia30.6KMT2A, ZBTB16, RUNX1, PML
14polycythemia30.5MPL, THPO
15polycythemia vera30.5THPO, MPL
16thrombocytosis30.4THPO, MPL
17b-cell chronic lymphocytic leukemia30.4BCL3, KMT2A, TRIM13
18adenocarcinoma30.4KMT2A, MME
19pancytopenia30.3THPO, KMT2A, MPL
20burkitt's lymphoma30.3ABL1, MME, RUNX1
21acute myeloid leukemia, adult30.3KMT2A, RUNX1
22chronic myeloproliferative disease30.3THPO, MPL
23acute myelomonocytic leukemia30.2RUNX1, KMT2A
24chronic myelomonocytic leukemia30.2MPL, RUNX1
25acute lymphoblastic leukemia, childhood30.1RUNX1, TLX1, MME, ABL1, KMT2A
26precursor b-cell acute lymphoblastic leukemia30.0MME, ABL1, KMT2A
27precursor t-cell acute lymphoblastic leukemia30.0RUNX1, TLX1, PICALM, ABL1, KMT2A, LYL1
28autoimmune thrombocytopenic purpura29.8THPO, MPL
29hematologic cancer29.4RUNX1, PICALM, MPL, ABL1, KMT2A, THPO
30myelodysplastic syndromes29.4RUNX1, MLF1, MPL, ABL1, KMT2A, THPO
31hemorrhagic thrombocythemia29.4MPL, THPO
32splenomegaly29.4THPO, MPL
33t-cell leukemia11.3
34childhood leukemia11.2
35adult t-cell leukemia11.1
36hairy cell leukemia11.0
37acute t cell leukemia11.0
38adult lymphoma10.9
39acute monocytic leukemia10.9
40prolymphocytic leukemia10.9
41juvenile myelomonocytic leukemia10.8
42lymphoid leukemia10.8
43central nervous system leukemia10.7
44myeloma10.7
45natural killer cell leukemia10.7
46sarcoma10.7
47adult acute lymphocytic leukemia10.6
48t-cell large granular lymphocyte leukemia10.6
49multiple myeloma10.6
50mast-cell leukemia10.6

Graphical network of the top 20 diseases related to Leukemia:



Diseases related to leukemia

Clinical Features for Leukemia

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Drugs & Therapeutics for Leukemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Leukemia

Drug clinical trials:

Search ClinicalTrials for Leukemia

Search NIH Clinical Center for Leukemia

Search CenterWatch for Leukemia

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Leukemia cell therapies at LifeMap Discovery.

Genetic Tests for Leukemia

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Anatomical Context for Leukemia

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32MalaCards
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MalaCards organs/tissues related to Leukemia:

32
Myeloid, T cells, B cells, Bone, Bone marrow, Monocytes, Endothelial, Breast, Lung, Skin, Liver, Prostate, Nk cells, Colon, Brain, Testes, Lymph node, Thyroid, B lymphoblasts, Spleen, Kidney, Pituitary, Testis, Smooth muscle, Heart, Thymus, Placenta, Spinal cord, Tonsil, Skeletal muscle, Cortex, Whole blood, Adipocyte, Retina, Pancreas, Uterus, Small intestine, Pineal, Eye, Adrenal cortex, Fetal liver, Tongue, Cardiac myocytes, Atrioventricular node, Adrenal gland, Temporal lobe, Fetal brain, Cerebellum, Cervix

Animal Models for Leukemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Leukemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538414.5LYL1, PML, RUNX1, TLX1, KAT6B, ARHGEF12
2MP:000538714.2MPL, PICALM, ARHGEF12, TLX1, RUNX1, PML
3MP:000539713.9PML, RUNX1, TLX1, ARHGEF12, PICALM, MPL
4MP:001076813.9PICALM, ARHGEF12, KAT6B, RUNX1, PML, MPL
5MP:000537813.2RUNX1, KAT6B, ARHGEF12, PICALM, MPL, SH3GL1
6MP:000537613.1ZBTB16, MPL, PICALM, RUNX1, MKL1, MME
7MP:000537011.7RUNX1, PICALM, MME, ABL1, KMT2A, SLC20A1
8MP:000538011.6TLX1, ABL2, KMT2A, SLC20A1
9MP:000363111.5KMT2A, ABL1, TLX1, RUNX1

Publications for Leukemia

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Sources:
50PubMed
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Articles related to Leukemia:

(show top 50)    (show all 23947)
idTitleAuthorsYear
1
RelB, together with RelA, sustains cell survival and confers proteasome inhibitor sensitivity of chronic lymphocytic leukemia cells from bone marrow. (24042463)
2014
2
Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6. (23429453)
2013
3
Leptomeningeal metastases from primary plasma cell leukemia. (24228268)
2013
4
Phase I study of quizartinib administered daily to patients with relapsed or refractory acute myeloid leukemia irrespective of FMS-like tyrosine kinase 3-internal tandem duplication status. (24002496)
2013
5
Sequence-specific electrochemical detection of double-strand PCR amplicons of PML/RARI+ fusion gene in acute promyelocytic leukemia. (23064710)
2013
6
Concomitant transformation of monoclonal gammopathy of undetermined significance to multiple myeloma and of essential thrombocythemia to acute biphenotypic leukemia 37 years after initial diagnosis. (24086946)
2013
7
SETBP1 mutations in 658 patients with myelodysplastic syndromes, chronic myelomonocytic leukemia and secondary acute myeloid leukemias. (23443343)
2013
8
Favorable outcome of patients with acute myeloid leukemia harboring a low-allelic burden FLT3-ITD mutation and concomitant NPM1 mutation: relevance to post-remission therapy. (23377436)
2013
9
Overcoming stroma-mediated treatment resistance in chronic lymphocytic leukemia through BCL-2 inhibition. (23614795)
2013
10
Elevated C-reactive protein is associated with shortened leukemia-free survival in patients with myelofibrosis. (23828261)
2013
11
Abnormalities of the der(12)t(12;21) in ETV6-RUNX1 acute lymphoblastic leukemia. (23077088)
2013
12
A multicenter blinded analysis indicates no association between chronic fatigue syndrome/myalgic encephalomyelitis and either xenotropic murine leukemia virus-related virus or polytropic murine leukemia virus. (22991430)
2012
13
A fatal case of acute pulmonary embolism caused by right ventricular masses of acute lymphoblastic lymphoma-leukemia in a 13 year old girl. (22844319)
2012
14
T315I mutation in Ph-positive acute lymphoblastic leukemia is associated with a highly aggressive disease phenotype: three case reports. (22593461)
2012
15
Antibody response to vaccines for rhinotracheitis, caliciviral disease, panleukopenia, feline leukemia, and rabies in tigers (Panthera tigris) and lions (Panthera leo). (22779227)
2012
16
BCR-ABL Translocation in Pediatric Acute Lymphoblastic Leukemia in Southern India. (23449388)
2012
17
Effects of methylenetetrahydrofolate reductase gene polymorphisms on toxicities during consolidation therapy in pediatric acute lymphoblastic leukemia in a Chinese population. (21534867)
2011
18
Identification of acquired copy number alterations and uniparental disomies in cytogenetically normal acute myeloid leukemia using high-resolution single-nucleotide polymorphism analysis. (20016533)
2010
19
CRLF2 and JAK2 in B-progenitor acute lymphoblastic leukemia: a novel association in oncogenesis. (20807819)
2010
20
Cryptic insertion of PML-RARA into the 3p25 locus in an acute promyelocytic leukemia with t(3;17)(p25;q21). (20633765)
2010
21
The degree of myelosuppression during maintenance therapy of adolescents with B-lineage intermediate risk acute lymphoblastic leukemia predicts risk of relapse. (20130603)
2010
22
Enzyme levels and G-463A polymorphism of myeloperoxidase in chronic lymphocytic leukemia and multiple myeloma. (19814685)
2009
23
Constitutive activation of the DNA damage signaling pathway in acute myeloid leukemia with complex karyotype: potential importance for checkpoint targeting therapy. (19843865)
2009
24
The first case of de novo B-cell prolymphocytic leukemia with central nervous system involvement: description of an unreported complication. (18929411)
2009
25
Successful treatment of warm antibody (IgG/C3 positive) autoimmune hemolytic anemia in hairy-cell leukemia with 2-CdA in the elderly. (18452105)
2008
26
Hemophagocytic lymphohistiocytosis onset during induction therapy for precursor B-cell acute lymphoblastic leukemia. (19131791)
2008
27
A novel mutation in the GATA1 gene associated with acute megakaryoblastic leukemia in a Korean Down syndrome patient. (19119459)
2008
28
Effects of psoralen plus long-wave ultraviolet-A on apoptosis of HL-60 leukemia cells]. (18664356)
2008
29
Autocrine insulin-like growth factor-I signaling promotes growth and survival of human acute myeloid leukemia cells via the phosphoinositide 3-kinase/Akt pathway. (17581609)
2007
30
Myeloid sarcoma of the vulva as the presenting symptom in a patient with acute myeloid leukemia. (17499347)
2007
31
Prognostic significance of FLT3 internal tandem duplication and NPM1 mutations in acute myeloid leukemia in an unselected patient population. (18192111)
2007
32
FLT3 internal tandem duplication in CD34+/CD33- precursors predicts poor outcome in acute myeloid leukemia. (16809615)
2006
33
Leukemia inhibitory factor induces endothelial differentiation in cardiac stem cells. (16407199)
2006
34
Induction of caspase-3-dependent apoptosis in human leukemia HL-60 cells by paclitaxel. (15963795)
2005
35
Polymorphism in the CD5 gene promoter in B-cell chronic lymphocytic leukemia and mantle cell lymphoma. (15981803)
2005
36
Trisomy 4 as the sole karyotypic abnormality in a case of acute biphenotypic leukemia with T-lineage markers in minimally differentiated acute myelocytic leukemia. (15041226)
2004
37
A phase I study of recombinant human leukemia inhibitory factor in patients with advanced cancer. (12796368)
2003
38
Occurrence of acute monocytic leukemia in a case of untreated WaldenstrAPm's macroglobulinemia. (12353307)
2002
39
Nucleolytic cleavage of the mixed lineage leukemia breakpoint cluster region during apoptosis. (11406628)
2001
40
Therapy-related myelodysplastic syndrome after eradication of acute promyelocytic leukemia: cytogenetic and molecular features. (11172306)
2001
41
Autologous peripheral blood stem cell transplantation for adults with B-lineage acute lymphoblastic leukemia: a pilot study. (10811452)
2000
42
Alveolar rhabdomyosarcoma presenting as leukemia. (9482423)
1998
43
A case of acute lymphoblastic leukemia, near-triploidy, and poor outcome: characterization by fluorescence in situ hybridization using chromosome-specific libraries from all human chromosomes. (9398861)
1997
44
Control of apoptosis in hematopoiesis and leukemia by cytokines, tumor suppressor and oncogenes. (8667646)
1996
45
Expression of cell cycle regulatory proteins in chronic lymphocytic leukemias. Comparison with non-Hodgkin's lymphomas and non-neoplastic lymphoid tissue. (7643628)
1995
46
Expression of the FMS/KIT-like gene FLT3 in human acute leukemias of the myeloid and lymphoid lineages. (1384791)
1992
47
Changes in IgG Fc receptor expression induced by phorbol 12-myristate 13-acetate treatment of THP-1 monocytic leukemia cells. (1532844)
1992
48
Growth failure and growth hormone deficiency in children after bone marrow transplantation for leukemia. (2331538)
1990
49
Chronic myelomonocytic leukemia (CMML)--characterization of clinical features and prognosis. (3247819)
1988
50
Acute myelomonocytic leukemia with macroglobulinemia, Bence Jones proteinuria, and hypercalcemia. (4197775)
1973

Genetic Variations for Leukemia

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Expression for genes affiliated with Leukemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Leukemia

Search GEO for disease gene expression data for Leukemia.

Pathways for genes affiliated with Leukemia

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29KEGG, 51QIAGEN, 53Reactome
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Pathways related to Leukemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
112.2LYL1, PML, RUNX1, TLX1, MLF1, ZBTB16
211.5PML, RUNX1, ZBTB16, ABL1
3
Hide members
11.2ZBTB16, RUNX1, PML
411.2ABL2, ABL1, ARHGEF12
511.2ABL2, ABL1, ARHGEF12
611.0ABL1, ABL2

Compounds for genes affiliated with Leukemia

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44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 59Tocris Bioscience
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Compounds related to Leukemia according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1tyrosine4413.5RUNX1, TLX1, ARHGEF12, MPL, ZBTB16, MME
2zinc44 2414.0KMT2A, PML, RUNX1, TLX1, KAT6B, MPL
3retinoic acid44 2413.7PML, RUNX1, ZBTB16, MME, ABL1, ABL2
4oligonucleotide4412.1RUNX1, TLX1, ARHGEF12, ABL1, KMT2A, THPO
5h2o24411.6PML, MME, ABL1, ABL2, THPO
6imatinib44 49 1113.6RUNX1, ABL1, ABL2, THPO
7etoposide44 49 59 1114.6PML, RUNX1, KMT2A, THPO
8actinomycin d4411.5THPO, KMT2A, MME, PML
9af 104411.5TLX1, PICALM, KMT2A
10megapoietin4411.2THPO, MPL
11anagrelide44 1112.0THPO, MPL
12cytarabine44 49 1112.9THPO, ABL1, MME

GO Terms for genes affiliated with Leukemia

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16Gene Ontology
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Cellular components related to Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563413.5LYL1, RUNX1, TLX1, KAT6B, PICALM, MLF1

Biological processes related to Leukemia according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1transcription, DNA-dependentGO:00635112.7PML, RUNX1, KAT6B, MLF1, ZBTB16, MKL1
2positive regulation of transcription, DNA-dependentGO:04589312.5RUNX1, KAT6B, PICALM, ZBTB16, KMT2A, BCL3
3myeloid cell differentiationGO:03009911.8THPO, ZBTB16, RUNX1, PML
4central nervous system developmentGO:00741711.8SH3GL1, ZBTB16, TLX1, RUNX1
5regulation of endocytosisGO:03010011.5PICALM, ABL1, ABL2
6hemopoiesisGO:03009711.5RUNX1, PICALM, ZBTB16
7positive regulation of transcription from RNA polymerase II promoterGO:04594411.4RUNX1, TLX1, MKL1, KMT2A, BCL3
8myeloid progenitor cell differentiationGO:00231811.2MLF1, RUNX1
9protein complex assemblyGO:00646111.2KMT2A, PICALM, PML
10positive regulation of oxidoreductase activityGO:05135311.2ABL2, ABL1
11regulation of actin cytoskeleton reorganizationGO:200024911.2ABL1, ABL2
12maintenance of protein location in nucleusGO:05145711.1BCL3, PML
13regulation of cell motilityGO:200014511.1ABL2, ABL1
14definitive hemopoiesisGO:06021611.0RUNX1, LYL1
15embryonic hemopoiesisGO:03516211.0KMT2A, RUNX1
16regulation of autophagyGO:01050610.9ABL2, ABL1

Molecular functions related to Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551514.7LYL1, PML, RUNX1, TLX1, KAT6B, ARHGEF12
2DNA bindingGO:00367712.5LYL1, BCL3, ABL1, ZBTB16, MLF1, KAT6B
3actin monomer bindingGO:00378510.9MKL1, ABL1, ABL2

Products for genes affiliated with Leukemia

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Sources for Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet