MCID: LKM002
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Leukemia malady

Cancer diseases category
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Summaries for Leukemia

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8Disease Ontology, 34MedlinePlus, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Leukemia is cancer of the white blood cells. white blood cells help your body fight infection. your blood cells form in your bone marrow. in leukemia, the bone marrow produces abnormal white blood cells. these cells crowd out the healthy blood cells, making it hard for blood to do its work. there are different types of leukemia, including acute lymphocytic leukemia acute myeloid leukemia chronic lymphocytic leukemia chronic myeloid leukemia leukemia can develop quickly or slowly. chronic leukemia grows slowly. in acute leukemia, the cells are very abnormal and their number increases rapidly. adults can get either type; childen with leukemia most often have an acute type. some leukemias can often be cured. other types are hard to cure, but you can often control them. treatments may include chemotherapy, radiation and stem cell transplantation. even if symptoms disappear, you might need therapy to prevent a relapse. nih: national cancer institute

MalaCards: Leukemia is related to myeloid leukemia and acute myeloid leukemia. An important gene associated with Leukemia is RUNX1 (runt-related transcription factor 1), and among its related pathways are Signaling by Robo receptor and Endometrial cancer. The drugs cytarabine and isotretinoin and the compounds megapoietin and anagrelide have been mentioned in the context of this disorder. Affiliated tissues include myeloid, t cells and b cells, and related mouse phenotypes are normal and liver/biliary system.

Disease Ontology:8 A cancer that affects the blood or bone marrow characterized by an abnormal proliferation of blood cells.

Wikipedia:65 Leukemia /lu?ki?mi???/ (American English) or leukaemia (British English) is a group of cancers that... more...

Aliases & Classifications for Leukemia

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8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 31LifeMap Discovery™, 62UMLS, 58SNOMED-CT, 27ICD9CM, 35MeSH, 40NCIt, 25ICD10
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Related Diseases for Leukemia

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17GeneCards, 18GeneDecks
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Diseases in the Leukemia family:

Acute Leukemia Subacute Leukemia

Diseases related to Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1186)
idRelated DiseaseScoreTop Affiliating Genes
1myeloid leukemia32.4RUNX1, ABL1, PICALM, MLF1, THPO, MPL
2acute myeloid leukemia32.3RUNX1, MLF1, SH3GL1
3chronic lymphocytic leukemia32.2ABL1, THPO, KMT2A, BCL3
4acute leukemia32.0PML, THPO, MLF1, ABL1, ZBTB16, RUNX1
5chronic myeloid leukemia32.0RUNX1, ABL1, THPO, PML, MPL, KMT2A
6acute promyelocytic leukemia32.0RUNX1, ZBTB16, PML, KMT2A
7b-cell chronic lymphocytic leukemia31.8KMT2A, BCL3, TRIM13
8acute lymphocytic leukemia31.7RUNX1, ABL1, PICALM, THPO, PML, MPL
9chronic myelomonocytic leukemia31.6MPL, RUNX1
10myelodysplastic syndromes31.6RUNX1, ABL1, MLF1, THPO, MPL, KMT2A
11acute myelomonocytic leukemia31.5RUNX1, KMT2A
12megakaryocytic leukemia31.3KMT2A, MKL1, THPO, RUNX1
13wilms tumor31.1ABL1, KMT2A, MME
14myelofibrosis31.0MPL, THPO
15myeloproliferative disorder31.0RUNX1, ABL1, THPO, MPL, KMT2A
16refractory anemia31.0MPL, THPO, RUNX1
17breast cancer31.0RUNX1, ABL1, THPO, PML, KMT2A, MME
18b-cell lymphomas30.9BCL3, MME, KMT2A
19non-hodgkin lymphoma30.9ZBTB16, PML, KMT2A, BCL3
20acute erythroid leukemia30.9MPL, THPO, MLF1
21thrombocytopenia30.8RUNX1, THPO, MPL
22prostate cancer30.7ZBTB16, ABL1, PML, KMT2A, MME, ARHGEF12
23polycythemia30.7THPO, MPL
24acute myeloid leukemia, adult30.6RUNX1, KMT2A
25pancytopenia30.6KMT2A, MPL, THPO
26purpura30.5THPO
27splenomegaly30.5MPL, THPO
28burkitt's lymphoma30.5RUNX1, ABL1, MME
29follicular lymphoma30.5KMT2A, MME, BCL3
30precursor t-cell acute lymphoblastic leukemia30.4RUNX1, ABL1, PICALM, KMT2A, LYL1
31acute lymphoblastic leukemia, childhood30.4MME, KMT2A, ABL1, RUNX1
32chronic myeloproliferative disease30.3THPO, MPL
33leukemia, acute lymphoblastic 330.3MME, KMT2A, ABL1
34thrombocythemia 130.2THPO
35autoimmune thrombocytopenic purpura29.9MPL, THPO
36lymphoblastic leukemia11.4
37t-cell leukemia11.3
38adult t-cell leukemia11.1
39hairy cell leukemia11.1
40childhood leukemia11.0
41monocytic leukemia11.0
42human t-cell leukemia virus type 111.0
43plasma cell leukemia10.9
44prolymphocytic leukemia10.9
45acute monocytic leukemia10.9
46juvenile myelomonocytic leukemia10.8
47large granular lymphocyte leukemia10.8
48hematopoietic stem cell transplantation10.8
49myeloma10.7
50t-cell prolymphocytic leukemia10.7

Graphical network of the top 20 diseases related to Leukemia:



Diseases related to leukemia

Symptoms for Leukemia

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Drugs & Therapeutics for Leukemia

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 62UMLS, 41NDF-RT
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Genetic Tests for Leukemia

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Anatomical Context for Leukemia

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33MalaCards
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MalaCards organs/tissues related to Leukemia:

33
Myeloid, T cells, B cells, Bone, Bone marrow, Monocytes, Endothelial, Breast, Lung, Skin, Testes, Liver, Prostate, Nk cells, Colon, Brain, Lymph node, Thyroid, B lymphoblasts, Spleen, Kidney, Pituitary, Testis, Smooth muscle, Thymus, Heart, Placenta, Spinal cord, Tonsil, Skeletal muscle, Cortex, Whole blood, Adipocyte, Retina, Pancreas, Uterus, Small intestine, Pineal, Eye, Adrenal cortex, Fetal liver, Tongue, Cardiac myocytes, Atrioventricular node, Adrenal gland, Temporal lobe, Fetal brain, Cerebellum, Cervix

Animal Models for Leukemia or affiliated genes

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37MGI
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Publications for Leukemia

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52PubMed
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Articles related to Leukemia:

(show top 50)    (show all 23698)
idTitleAuthorsYear
1
Intraventricular hemorrhage in a patient with chronic myeloid leukemia and anterior communicating artery aneurysm. (23860156)
2013
2
MicroRNA profiling reveals aberrant microRNA expression in adult ETP-ALL and functional studies implicate a role for miR-222 in acute leukemia. (23522449)
2013
3
Reply to myelosuppression after frontline fludarabine, cyclophosphamide, and rituximab in patients with chronic lymphocytic leukemia: Analysis of Persistent and New-Onset Cytopenia. (24151154)
2013
4
Renal Infarction Secondary to Invasive Aspergillosis in a 5-Year-Old Girl With Acute Lymphoblastic Leukemia. (24136022)
2013
5
Characterization of bone marrow mast cells in acute myeloid leukemia with t(8;21) (q22;q22); RUNX1-RUNX1T1. (24035334)
2013
6
Treatment-, patient-, and disease-related factors and the emergence of adverse events with tyrosine kinase inhibitors for the treatment of chronic myeloid leukemia. (23553655)
2013
7
Defining consensus leukemia-associated immunophenotypes for detection of minimal residual disease in acute myeloid leukemia in a multicenter setting. (23912609)
2013
8
Prognostic value of plasma levels of thrombomodulin and von Willebrand factor in Egyptian children with acute lymphoblastic leukemia. (24243921)
2013
9
Wiskott-Aldrich syndrome with unusual clinical features similar to juvenile myelomonocytic leukemia. (22736231)
2012
10
Mogamulizumab for the treatment of adult T-cell leukemia/lymphoma. (23110261)
2012
11
CD117 expression is a sensitive but nonspecific predictor of FLT3 mutation in T acute lymphoblastic leukemia and T/myeloid acute leukemia. (22261446)
2012
12
Rapid screening of ASXL1, IDH1, IDH2, and c-CBL mutations in de novo acute myeloid leukemia by high-resolution melting. (22929312)
2012
13
MLL-AF9 and MLL-ENL alter the dynamic association of transcriptional regulators with genes critical for leukemia. (20854876)
2011
14
DNMT3A mutations are rare in childhood acute myeloid leukemia. (21685466)
2011
15
Treatment of therapy related acute promyelocytic leukemia with the combination of all trans retinoic acid and arsenic trioxide without chemotherapy: a series of three patients. (20350274)
2010
16
TP53 mutation profile in chronic lymphocytic leukemia: evidence for a disease specific profile from a comprehensive analysis of 268 mutations. (20861914)
2010
17
An unusual case of febrile neutropenia: acute myeloid leukemia presenting as myeloid sarcoma of the spleen. (18717148)
2008
18
Concomitant EBV-related B-cell proliferation and juvenile myelomonocytic leukemia in a 2-year-old child. (17618684)
2008
19
Fludarabine induces apoptosis of human T-cell leukemia virus type 1-infected T cells via inhibition of the nuclear factor-kappaB signal pathway. (17344917)
2007
20
The role of WWP1-Gag interaction and Gag ubiquitination in assembly and release of human T-cell leukemia virus type 1. (17609263)
2007
21
Expression of CLLU1 in patients with chronic lymphocytic leukemia and its prognostic significance]. (18457263)
2007
22
Combined high-resolution array-based comparative genomic hybridization and expression profiling of ETV6/RUNX1-positive acute lymphoblastic leukemias reveal a high incidence of cryptic Xq duplications and identify several putative target genes within the commonly gained region. (17690704)
2007
23
Troglitazone inhibits cell growth and induces apoptosis of B-cell acute lymphoblastic leukemia cells with t(14;18). (16809887)
2006
24
Blocking NF-kappaB as a potential strategy to treat adult T-cell leukemia/lymphoma. (16823495)
2006
25
Purine nucleoside analogues and combination therapies in B-cell chronic lymphocytic leukemia: dawn of a new era. (15068894)
2004
26
Prognostic factors in myelodysplastic and myeloproliferative types of chronic myelomonocytic leukemia: a retrospective analysis of 83 patients from a single institution. (15257942)
2004
27
Recent progress in the protein-tyrosine phosphatase SHP1 gene: the significant correlation of the SHP1 gene silencing with the onset of lymphomas/leukemias]. (14619449)
2003
28
Hodgkin's type of Richter's syndrome in familial chronic lymphocytic leukemia treated with cladribine and cyclophosphamide. (12802926)
2003
29
Phase I trial of a novel diphtheria toxin/granulocyte macrophage colony-stimulating factor fusion protein (DT388GMCSF) for refractory or relapsed acute myeloid leukemia. (12006512)
2002
30
Preferential expression of the transcription coactivator HTIF1alpha gene in acute myeloid leukemia and MDS-related AML. (11986951)
2002
31
Cytotoxic efficacy of bendamustine in human leukemia and breast cancer cell lines. (12029443)
2002
32
Homologous recombinational repair vis-A -vis chlorambucil resistance in chronic lymphocytic leukemia. (12007561)
2002
33
BCRP gene expression is associated with a poor response to remission induction therapy in childhood acute myeloid leukemia. (12145683)
2002
34
Activity and expression of the multidrug resistance proteins P-glycoprotein, MRP1, MRP2, MRP3 and MRP5 in de novo and relapsed acute myeloid leukemia. (11587212)
2001
35
Cytokine expression of T cells in chronic myeloid leukemia. (11775253)
2000
36
Identification of a human T-cell leukemia virus type I tax peptide in contact with DNA. (10567395)
1999
37
Acute dacryocystitis as a presenting sign of pediatric leukemia. (10372893)
1999
38
Okadaic acid-induced apoptosis of HL60 leukemia cells is preceded by destabilization of bcl-2 mRNA and downregulation of bcl-2 protein. (9762907)
1998
39
Myeloperoxidase gene expression in infant leukemia: a Pediatric Oncology Group Study. (9638984)
1998
40
Life-threatening hyperleukocytosis and pulmonary compromise after priming with recombinant human granulocyte-macrophage colony-stimulating factor in a patient with acute myelomonocytic leukemia. (7799037)
1995
41
Hypercalcemia associated with all-trans-retinoic acid in the treatment of acute promyelocytic leukemia. (8501972)
1993
42
Chemotherapy-related side effects in children with acute lymphocytic leukemia in Taiwan: a nursing perspective. (1514401)
1992
43
Amplification of ETS2 oncogene in acute nonlymphoblastic leukemia with t(6;21;18). (1728954)
1992
44
Hairy cell leukemia: splenectomy after alpha 2b-interferon therapy. (1878598)
1991
45
Results of the vincristine, doxorubicin, and dexamethasone regimen in adults with standard- and high-risk acute lymphocytic leukemia. (2189958)
1990
46
Effects of the antisense v-myb' expression on K562 human leukemia cell proliferation and differentiation. (1979645)
1990
47
Acute non-lymphoblastic leukemia. Correlation between clinical and hematological parameters in 87 adult patients. (3121464)
1987
48
An intensive care chemo- or chemoimmunotherapy regimen for patients with intermediate and poor-prognosis acute lymphatic leukemia and leukemic lymphoblastic lymphosarcoma: preliminary results with 14-month median follow-up. (6949235)
1982
49
Myeloblastic leukemia and congenital hemihypertrophy. (192872)
1977
50
Periarteritis nodosa simulating eosinophilic leukemia; a case report. (14771060)
1950

Variations for Leukemia

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Expression for genes affiliated with Leukemia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Leukemia

Search GEO for disease gene expression data for Leukemia.

Pathways for genes affiliated with Leukemia

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50PathCards, 55Reactome, 30KEGG, 60Thomson Reuters, 54R&D Systems, 38NCBI BioSystems Database, 53QIAGEN
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Compounds for genes affiliated with Leukemia

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45Novoseek, 11DrugBank, 51PharmGKB, 61Tocris Bioscience, 24HMDB, 29IUPHAR
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Compounds related to Leukemia according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1megapoietin4510.7MPL, THPO
2anagrelide45 1111.6THPO, MPL
3af 104510.6KMT2A, PICALM
4etoposide45 51 61 1113.5RUNX1, THPO, PML, KMT2A
5imatinib45 51 1112.5RUNX1, ABL2, ABL1, THPO
6cytarabine45 51 1112.4MME, THPO, ABL1
7actinomycin d4510.4THPO, PML, KMT2A, MME
8h2o24510.4ABL2, ABL1, THPO, PML, MME
9oligonucleotide4510.4ARHGEF12, KMT2A, THPO, ABL1, RUNX1
10vegf4510.4RUNX1, ABL1, THPO, MPL, MME
11zinc45 2411.3RUNX1, ZBTB16, ABL1, PML, MPL, KMT2A
12proline4510.3RUNX1, ABL1, PML, KMT2A
13dmso4510.3THPO, ABL1, RUNX1
14retinoic acid45 2411.3RUNX1, ZBTB16, ABL2, ABL1, THPO, PML
15gtp45 2911.3ABL1, MPL, KMT2A, ARHGEF12
16lysine4510.2THPO, PML, MPL, MME
17tyrosine4510.1ARHGEF12, RUNX1, ZBTB16, ABL2, ABL1, THPO
18leucine4510.1PICALM, PML, KMT2A, MME
19cysteine459.9ABL1, THPO, PML, MPL, MME

GO Terms for genes affiliated with Leukemia

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16Gene Ontology
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Cellular components related to Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1histone methyltransferase complexGO:03509710.3KMT2B, KMT2A
2nucleusGO:0056349.6BCL3, RUNX1, ZBTB16, ABL1, PICALM, MLF1
3cytoplasmGO:0057379.5PML, MKL1, MLF1, ABL1, SH3GL1, KMT2A

Biological processes related to Leukemia according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1myeloid progenitor cell differentiationGO:00231810.7MLF1, RUNX1
2hemopoiesisGO:03009710.6RUNX1, ZBTB16, PICALM
3regulation of histone H3-K4 methylationGO:05156910.6KMT2B, KMT2A
4myeloid cell differentiationGO:03009910.6PML, THPO, ZBTB16, RUNX1
5positive regulation of oxidoreductase activityGO:05135310.6ABL2, ABL1
6regulation of endocytosisGO:03010010.6ABL2, ABL1, PICALM
7regulation of actin cytoskeleton reorganizationGO:200024910.6ABL1, ABL2
8histone H3-K4 trimethylationGO:08018210.6KMT2B, KMT2A
9negative regulation of viral release from host cellGO:190218710.6PML, TRIM13
10regulation of cell motilityGO:200014510.6ABL2, ABL1
11maintenance of protein location in nucleusGO:05145710.5PML, BCL3
12definitive hemopoiesisGO:06021610.5RUNX1, LYL1
13central nervous system developmentGO:00741710.5RUNX1, ZBTB16, SH3GL1
14positive regulation of transcription, DNA-templatedGO:04589310.4RUNX1, ZBTB16, PICALM, KMT2A, LYL1, BCL3
15protein complex assemblyGO:00646110.4KMT2A, PML, PICALM
16histone H3-K4 methylationGO:05156810.4KMT2B, KMT2A
17intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:04277110.3BCL3, PML
18regulation of autophagyGO:01050610.3ABL2, ABL1
19transcription, DNA-templatedGO:00635110.3RUNX1, ZBTB16, MLF1, MKL1, PML, KMT2B
20embryonic hemopoiesisGO:03516210.2KMT2A, RUNX1
21response to gamma radiationGO:01033210.0TRIM13, PML

Molecular functions related to Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1histone methyltransferase activity (H3-K4 specific)GO:04280010.3KMT2B, KMT2A
2actin monomer bindingGO:00378510.3ABL2, ABL1, MKL1
3DNA bindingGO:0036779.8RUNX1, ZBTB16, ABL1, MLF1, PML, KMT2B
4sequence-specific DNA binding transcription factor activityGO:0037009.8RUNX1, ZBTB16, MKL1, KMT2A, KMT2B, BCL3
5protein bindingGO:0055159.4ARHGEF12, RUNX1, ZBTB16, ABL2, ABL1, PICALM

Products for genes affiliated with Leukemia

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Sources for Leukemia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet