MCID: LKM002
MIFTS: 79

Leukemia malady

Cancer diseases category

Summaries for Leukemia

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Leukemia is cancer of the white blood cells. white blood cells help your body fight infection. your blood cells form in your bone marrow. in leukemia, the bone marrow produces abnormal white blood cells. these cells crowd out the healthy blood cells, making it hard for blood to do its work. there are different types of leukemia, including acute lymphocytic leukemia acute myeloid leukemia chronic lymphocytic leukemia chronic myeloid leukemia leukemia can develop quickly or slowly. chronic leukemia grows slowly. in acute leukemia, the cells are very abnormal and their number increases rapidly. adults can get either type; childen with leukemia most often have an acute type. some leukemias can often be cured. other types are hard to cure, but you can often control them. treatments may include chemotherapy, radiation and stem cell transplantation. even if symptoms disappear, you might need therapy to prevent a relapse. nih: national cancer institute

MalaCards: Leukemia is related to acute leukemia and myeloid leukemia. An important gene associated with Leukemia is RUNX1 (runt-related transcription factor 1), and among its related pathways are Transcriptional misregulation in cancer and Pathways in cancer. The drugs irinotecan and irinotecan hydrochloride and the compounds tyrosine and zinc have been mentioned in the context of this disorder. Affiliated tissues include myeloid, t cells and b cells, and related mouse phenotypes are cellular and immune system.

Disease Ontology:8 A cancer that affects the blood or bone marrow characterized by an abnormal proliferation of blood cells.

Wikipedia:63 Leukemia (American English) or leukaemia (British English) is a type of cancer of the blood or bone... more...

Aliases & Classifications for Leukemia

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8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 27ICD9CM, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Related Diseases for Leukemia

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17GeneCards, 18GeneDecks
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Diseases in the Leukemia family:

Subacute Leukemia Acute Leukemia

Diseases related to Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1050)
idRelated DiseaseScoreTop Affiliating Genes
1acute leukemia32.5RUNX1, MLF1, MPL, ZBTB16, ABL1, KMT2A
2myeloid leukemia32.2RUNX1, PICALM, MLF1, MPL, ABL1, KMT2A
3acute myeloid leukemia32.1RUNX1, ARHGEF12, PICALM, MLF1, SH3GL1
4lymphoblastic leukemia32.0TLX1
5chronic lymphocytic leukemia32.0BCL3, THPO, KMT2A, ABL1
6chronic myeloid leukemia31.8PML, RUNX1, MPL, ABL1, KMT2A, THPO
7acute lymphocytic leukemia31.6PML, RUNX1, PICALM, MPL, MME, ABL1
8monocytic leukemia31.5RUNX1, KAT6B, KMT2A
9megakaryocytic leukemia31.1THPO, KMT2A, MKL1, RUNX1
10myelofibrosis30.8MPL, THPO
11breast cancer30.8PML, RUNX1, MME, ABL1, KMT2A, THPO
12non-hodgkin lymphoma30.7PML, ZBTB16, KMT2A, BCL3
13acute promyelocytic leukemia30.6KMT2A, ZBTB16, RUNX1, PML
14polycythemia30.5MPL, THPO
15polycythemia vera30.5THPO, MPL
16thrombocytosis30.4THPO, MPL
17b-cell chronic lymphocytic leukemia30.4BCL3, KMT2A, TRIM13
18adenocarcinoma30.4KMT2A, MME
19pancytopenia30.3THPO, KMT2A, MPL
20burkitt's lymphoma30.3ABL1, MME, RUNX1
21acute myeloid leukemia, adult30.3KMT2A, RUNX1
22chronic myeloproliferative disease30.3THPO, MPL
23acute myelomonocytic leukemia30.2RUNX1, KMT2A
24chronic myelomonocytic leukemia30.2MPL, RUNX1
25acute lymphoblastic leukemia, childhood30.1RUNX1, TLX1, MME, ABL1, KMT2A
26precursor b-cell acute lymphoblastic leukemia30.0MME, ABL1, KMT2A
27precursor t-cell acute lymphoblastic leukemia30.0RUNX1, TLX1, PICALM, ABL1, KMT2A, LYL1
28autoimmune thrombocytopenic purpura29.8THPO, MPL
29hematologic cancer29.4RUNX1, PICALM, MPL, ABL1, KMT2A, THPO
30myelodysplastic syndromes29.4RUNX1, MLF1, MPL, ABL1, KMT2A, THPO
31hemorrhagic thrombocythemia29.4MPL, THPO
32splenomegaly29.4THPO, MPL
33t-cell leukemia11.3
34childhood leukemia11.2
35adult t-cell leukemia11.1
36hairy cell leukemia11.0
37acute t cell leukemia11.0
38adult lymphoma10.9
39acute monocytic leukemia10.9
40prolymphocytic leukemia10.9
41juvenile myelomonocytic leukemia10.8
42lymphoid leukemia10.8
43central nervous system leukemia10.7
44myeloma10.7
45natural killer cell leukemia10.7
46sarcoma10.7
47adult acute lymphocytic leukemia10.6
48t-cell large granular lymphocyte leukemia10.6
49multiple myeloma10.6
50mast-cell leukemia10.6

Graphical network of the top 20 diseases related to Leukemia:



Diseases related to leukemia

Clinical Features for Leukemia

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Drugs & Therapeutics for Leukemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Leukemia

Drug clinical trials:

Search ClinicalTrials for Leukemia

Search NIH Clinical Center for Leukemia

Search CenterWatch for Leukemia

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Leukemia cell therapies at LifeMap Discovery.

Genetic Tests for Leukemia

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Anatomical Context for Leukemia

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32MalaCards
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MalaCards organs/tissues related to Leukemia:

32
Myeloid, T cells, B cells, Bone, Bone marrow, Monocytes, Endothelial, Breast, Lung, Skin, Liver, Prostate, Nk cells, Colon, Brain, Testes, Lymph node, Thyroid, B lymphoblasts, Spleen, Kidney, Pituitary, Testis, Smooth muscle, Heart, Thymus, Placenta, Tonsil, Spinal cord, Skeletal muscle, Adipocyte, Cortex, Whole blood, Pancreas, Uterus, Retina, Small intestine, Fetal liver, Pineal, Tongue, Adrenal cortex, Eye, Cardiac myocytes, Cervix, Fetal brain, Temporal lobe, Atrioventricular node, Cerebellum, Adrenal gland

Animal Models for Leukemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Leukemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538414.5MPL, ABL2, ABL1, MKL1, ZBTB16, SLC20A1
2MP:000538714.2KMT2A, THPO, LYL1, BCL3, SLC20A1, ABL1
3MP:000539713.9RUNX1, TLX1, ARHGEF12, PICALM, MPL, ZBTB16
4MP:001076813.9BCL3, PML, RUNX1, SLC20A1, KMT2A, ABL2
5MP:000537813.2MKL1, KMT2A, ABL2, ABL1, SH3GL1, SLC20A1
6MP:000537613.1PICALM, MPL, RUNX1, ZBTB16, MKL1, ABL1
7MP:000537011.7SLC20A1, ABL1, MME, PICALM, RUNX1, KMT2A
8MP:000538011.6ABL2, SLC20A1, KMT2A, TLX1
9MP:000363111.5KMT2A, RUNX1, ABL1, TLX1

Publications for Leukemia

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Sources:
50PubMed
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Articles related to Leukemia:

(show top 50)    (show all 23947)
idTitleAuthorsYear
1
A novel acidic serine protease, ASPNJ inhibits proliferation, induces apoptosis and enhances chemo-susceptibility of acute promyelocytic leukemia cell. (24169085)
2013
2
Therapy-related acute promyelocytic leukemia: a systematic review. (23771799)
2013
3
Sorafenib As Monotherapy or in Association With Cytarabine and Clofarabine for the Treatment of Relapsed/Refractory FLT3 ITD-Positive Advanced Acute Myeloid Leukemia. (24144836)
2013
4
Combined chronic lymphocytic leukemia and prolactinoma: a rare occurrence in a patient presenting with pituitary apoplexy. (23683075)
2013
5
GCN5 acetylates and regulates the stability of the oncoprotein E2A-PBX1 in acute lymphoblastic leukemia. (23044487)
2013
6
Evaluation of xenotropic murine leukemia virus and its R426Q polymorphism in patients with prostate cancer in Kerman, southeast of Iran. (23098452)
2012
7
T-cell leukemia. (22858027)
2012
8
Value of survival gains in chronic myeloid leukemia. (23327457)
2012
9
Genetic variations in CD14 promoter and acute lymphoblastic leukemia susceptibility in a Chinese population. (21476947)
2011
10
The effects of mifepristone on the expressions of osteopontin, interleukin-6 and leukemia inhibitory factor in the villi of early pregnant women. (20851233)
2010
11
Plasma cell leukemia. (20442443)
2010
12
Mutual exclusion of ASXL1 and NPM1 mutations in a series of acute myeloid leukemias. (19865112)
2010
13
Dosing of a phase I study of KW-0761, an anti-CCR4 antibody, for adult T-cell leukemia-lymphoma and peripheral T-cell lymphoma. (20566994)
2010
14
Mechanisms of transcriptional regulation by MLL and its disruption in acute leukemia. (18224408)
2008
15
Mutations of the TP53 gene in acute myeloid leukemia are strongly associated with a complex aberrant karyotype. (18528419)
2008
16
Chronic myeloid leukemia-associated membranoproliferative glomerulonephritis that responded to imatinib mesylate therapy. (17390742)
2007
17
Antibody microarray analysis of inflammatory mediator release by human leukemia T-cells and human non small cell lung cancer cells. (17916797)
2007
18
Methotrexate-induced mucositis in acute leukemia patients is not associated with the MTHFR 677T allele in Mexico. (17891601)
2007
19
Inhibition of HuR and MMP-9 expression in macrophage-differentiated HL-60 myeloid leukemia cells by green tea polyphenol EGCg. (17081606)
2007
20
The G(-248)A polymorphism in the promoter region of the Bax gene does not correlate with prognostic markers or overall survival in chronic lymphocytic leukemia. (16307023)
2006
21
beta-Glucuronidase is an optimal normalization control gene for molecular monitoring of chronic myelogenous leukemia. (16825513)
2006
22
Systemic B-cell chronic lymphocytic leukemia first presenting as a cutaneous infiltrate arising at the site of a herpes simplex scar. (15920448)
2005
23
Radiation-induced apoptosis is independent of caspase-8 but dependent on cytochrome c and the caspase-9 cascade in human leukemia HL60 cells. (16210785)
2005
24
Imatinib mesylate in the treatment of Core Binding Factor leukemias with KIT mutations. A report of three cases. (15725473)
2005
25
Flavones and polyphenols inhibit the NO pathway during apoptosis of leukemia B-cells. (15203283)
2004
26
Molecular cloning, sequence and expression pattern analysis of the mouse orthologue of the leukemia-associated guanine nucleotide exchange factor. (15276214)
2004
27
Constitutively activated phosphatidylinositol 3-kinase primes platelets from patients with chronic myelogenous leukemia for thrombopoietin-induced aggregation. (15085152)
2004
28
Arsenic trioxide inhibits translation of mRNA of bcr-abl, resulting in attenuation of Bcr-Abl levels and apoptosis of human leukemia cells. (14633726)
2003
29
Immunoglobulin kappa deleting element rearrangements in precursor-B acute lymphoblastic leukemia are stable targets for detection of minimal residual disease by real-time quantitative PCR. (11986956)
2002
30
Regulation of cell cycle progression and apoptosis by beta-carotene in undifferentiated and differentiated HL-60 leukemia cells: possible involvement of a redox mechanism. (11807783)
2002
31
Activation of clg, a novel dbl family guanine nucleotide exchange factor gene, by proviral insertion at evi24, a common integration site in B cell and myeloid leukemias. (11839748)
2002
32
Cutaneous lymphocytic vasculitis as the presenting feature of acute lymphoblastic leukemia. (12368694)
2002
33
Molecular genetics of human leukemias: new insights into therapy. (12447846)
2002
34
Crosstalk between BCR/ABL oncoprotein and CXCR4 signaling through a Src family kinase in human leukemia cells. (12208881)
2002
35
Erythropoietin-dependent transformation of myelodysplastic syndrome to acute monoblastic leukemia. (11719396)
2001
36
Tissue factors on acute promyelocytic leukemia and endothelial cells are differently regulated by retinoic acid, arsenic trioxide and chemotherapeutic agents. (10400422)
1999
37
FLT3 ligand inhibits apoptosis and promotes survival of myeloid leukemia cell lines. (10048431)
1999
38
cDNA cloning, expression pattern, and chromosomal localization of Mlf1, murine homologue of a gene involved in myelodysplasia and acute myeloid leukemia. (10393836)
1999
39
Secondary leukemia responsive to retinoic acid with abnormal localization of RARalpha protein: a report of two cases. (9616182)
1998
40
A randomized controlled trial of filgrastim during remission induction and consolidation chemotherapy for adults with acute lymphoblastic leukemia: CALGB study 9111. (9716583)
1998
41
C/EBP-epsilon: chromosomal mapping and mutational analysis of the gene in leukemia and preleukemia. (9393598)
1997
42
Shortened survival after relapse in T-cell acute lymphoblastic leukemia patients with p16/p15 deletions. (9279366)
1997
43
Expression of CD45RA and CD45RO antigens and its implication in leukemias]. (15624328)
1997
44
Fluorescent in-situ hybridization technique (FISH) in the diagnosis of Philadelphia translocation in chronic myeloid leukemia]. (8685681)
1996
45
Prognostic value of immunophenotyping in acute myeloid leukemia. Australian Leukaemia Study Group. (8049437)
1994
46
Modulation of 1-[beta-D-arabinofuranosyl] cytosine-induced apoptosis in human myeloid leukemia cells by staurosporine and other pharmacological inhibitors of protein kinase C. (7949469)
1994
47
Sphinganine potentiation of dimethyl sulfoxide-induced granulocyte differentiation, increase of alkaline phosphatase activity and decrease of protein kinase C activity in a human leukemia cell line (HL-60). (8135836)
1994
48
A laboratory and clinical study of induced differentiation therapy by all trans-retinoic acid in acute promyelocytic leukemia]. (1425005)
1992
49
Chromosomal translocation t(14;19) as indicated by bcl-3 rearrangement is a rare phenomenon in non-Hodgkin's lymphoma and chronic lymphocytic leukemia: a molecular genetic analysis of 176 cases. (2243504)
1990
50
Familial chronic lymphocytic leukemia. (4184386)
1969

Genetic Variations for Leukemia

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Expression for genes affiliated with Leukemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Leukemia

Search GEO for disease gene expression data for Leukemia.

Pathways for genes affiliated with Leukemia

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29KEGG, 51QIAGEN, 53Reactome
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Pathways related to Leukemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
112.2LYL1, PML, RUNX1, TLX1, MLF1, ZBTB16
211.5PML, ABL1, ZBTB16, RUNX1
3
Hide members
11.2RUNX1, PML, ZBTB16
411.2ABL2, ABL1, ARHGEF12
511.2ARHGEF12, ABL1, ABL2
611.0ABL2, ABL1

Compounds for genes affiliated with Leukemia

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44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 59Tocris Bioscience
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Compounds related to Leukemia according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1tyrosine4413.5RUNX1, TLX1, ARHGEF12, MPL, ZBTB16, MME
2zinc44 2414.0KMT2A, PML, RUNX1, TLX1, KAT6B, MPL
3retinoic acid44 2413.7PML, RUNX1, ZBTB16, MME, ABL1, ABL2
4oligonucleotide4412.1RUNX1, TLX1, ARHGEF12, ABL1, KMT2A, THPO
5h2o24411.6PML, MME, ABL1, ABL2, THPO
6imatinib44 49 1113.6RUNX1, ABL1, ABL2, THPO
7etoposide44 49 59 1114.6PML, RUNX1, KMT2A, THPO
8actinomycin d4411.5THPO, KMT2A, MME, PML
9af 104411.5TLX1, PICALM, KMT2A
10megapoietin4411.2THPO, MPL
11anagrelide44 1112.0THPO, MPL
12cytarabine44 49 1112.9THPO, ABL1, MME

GO Terms for genes affiliated with Leukemia

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16Gene Ontology
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Cellular components related to Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563413.5LYL1, RUNX1, TLX1, KAT6B, PICALM, MLF1

Biological processes related to Leukemia according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1transcription, DNA-dependentGO:00635112.7MLF1, MKL1, ZBTB16, KAT6B, RUNX1, PML
2positive regulation of transcription, DNA-dependentGO:04589312.5KAT6B, LYL1, RUNX1, BCL3, KMT2A, ZBTB16
3myeloid cell differentiationGO:03009911.8ZBTB16, RUNX1, PML, THPO
4central nervous system developmentGO:00741711.8ZBTB16, TLX1, RUNX1, SH3GL1
5regulation of endocytosisGO:03010011.5PICALM, ABL1, ABL2
6hemopoiesisGO:03009711.5ZBTB16, PICALM, RUNX1
7positive regulation of transcription from RNA polymerase II promoterGO:04594411.4RUNX1, TLX1, KMT2A, BCL3, MKL1
8myeloid progenitor cell differentiationGO:00231811.2MLF1, RUNX1
9protein complex assemblyGO:00646111.2KMT2A, PICALM, PML
10positive regulation of oxidoreductase activityGO:05135311.2ABL2, ABL1
11regulation of actin cytoskeleton reorganizationGO:200024911.2ABL2, ABL1
12maintenance of protein location in nucleusGO:05145711.1PML, BCL3
13regulation of cell motilityGO:200014511.1ABL1, ABL2
14definitive hemopoiesisGO:06021611.0LYL1, RUNX1
15embryonic hemopoiesisGO:03516211.0RUNX1, KMT2A
16regulation of autophagyGO:01050610.9ABL2, ABL1

Molecular functions related to Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551514.7PML, ABL1, MME, MKL1, TRIM13, SH3GL1
2DNA bindingGO:00367712.5BCL3, ABL1, ZBTB16, MLF1, KAT6B, RUNX1
3actin monomer bindingGO:00378510.9MKL1, ABL1, ABL2

Products for genes affiliated with Leukemia

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Sources for Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet