MCID: LKM062
MIFTS: 58

Leukemia, Acute Lymphoblastic malady

Genetic diseases, Rare diseases, Cancer diseases, Blood diseases, Immune diseases categories

Summaries for Leukemia, Acute Lymphoblastic

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MedlinePlus:32 Leukemia is cancer of the white blood cells. white blood cells help your body fight infection. your blood cells form in your bone marrow. in leukemia, however, the bone marrow produces abnormal white blood cells. these cells crowd out the healthy blood cells, making it hard for blood to do its work. in acute lymphocytic leukemia (all), also called acute lymphoblastic leukemia, there are too many of specific types of white blood cells called lymphocytes or lymphoblasts. all is the most common type of cancer in children. possible risk factors for all include being male, being white, previous chemotherapy treatment, exposure to radiation, and for adults, being older than 70. symptoms of all include: weakness or feeling tired fever easy bruising or bleeding bleeding under the skin shortness of breath weight loss or loss of appetite pain in the bones or stomach pain or a feeling of fullness below the ribs painless lumps in the neck, underarm, stomach, or groin tests that examine the blood and bone marrow diagnose all. treatments include chemotherapy, radiation therapy, stem cell transplants, and targeted therapy. targeted therapy uses substances that attack cancer cells without harming normal cells. once the leukemia is in remission, you need additional treatment to make sure that it does not come back. nih: national cancer institute

MalaCards based summary: Leukemia, Acute Lymphoblastic, also known as acute lymphocytic leukemia, is related to precursor b-cell acute lymphoblastic leukemia and burkitt lymphoma, and has symptoms including acute lymphatic leukemiaand polygenic inheritance. An important gene associated with Leukemia, Acute Lymphoblastic is BAX (BCL2-associated X protein), and among its related pathways are Sorafenib Pharmacodynamics and Id Signaling Pathway. The drugs mercaptopurine and asparaginase and the compounds homoharringtonine and ponatinib have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, bone and monocytes, and related mouse phenotypes are hearing/vestibular/ear and hematopoietic system.

Disease Ontology:9 A lymphoblastic leukemia that is characterized by over production of lymphoblasts.

OMIM:45 Acute lymphoblastic leukemia (ALL), also known as acute lymphocytic leukemia, is a subtype of acute leukemia, a cancer... (613065) more...

Aliases & Classifications for Leukemia, Acute Lymphoblastic

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Sources:
45OMIM, 30LifeMap Discovery®, 9Disease Ontology, 10diseasecard, 41NIH Rare Diseases, 43Novoseek, 47Orphanet, 32MedlinePlus, 60UMLS, 55SNOMED-CT, 27ICD9CM, 38NCIt, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Leukemia, Acute Lymphoblastic, Aliases & Descriptions:

Name: Leukemia, Acute Lymphoblastic 45 10 30
Acute Lymphocytic Leukemia 30 9 41 32 60
Acute Lymphoblastic Leukemia 30 9 41
Acute Monoblastic Leukemia 41 47 60
Acute Monocytic Leukemia 41 47 60
Acute Myeloblastic Leukemia Type 5 41 47
Aml-M5 41 47
Leukemia, Acute Lymphoblastic, Susceptibility to 10
 
Precursor Cell Lymphoblastic Leukemia Lymphoma 60
T-Cell Acute Lymphoblastic Leukemia, Somatic 45
M5b Acute Differentiated Monocytic Leukemia 60
Leukemia, Acute Lymphoblastic, Somatic 45
Lymphoblastic Leukemia Acute 43
Leukemia, Acute Lymphocytic 45
All 41


Classifications:



Characteristics (Orphanet epidemiological data):

47
acute monoblastic leukemia:
Prevalence: 1-9/1000000 (Europe); Age of onset: Childhood


External Ids:

OMIM45 613065
Disease Ontology9 DOID:9952
ICD9CM27 204.0
NCIt38 C3167
Orphanet47 514
MESH via Orphanet34 D007948
ICD10 via Orphanet26 C92.7
UMLS via Orphanet61 C0457334, C1318544
ICD1025 C91.0

Related Diseases for Leukemia, Acute Lymphoblastic

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Diseases in the Lymphoblastic Leukemia family:

leukemia, acute lymphoblastic Leukemia, Acute Lymphoblastic 3

Diseases related to Leukemia, Acute Lymphoblastic via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 409)
idRelated DiseaseScoreTop Affiliating Genes
1precursor b-cell acute lymphoblastic leukemia31.4BCR, PAX5, FLT3
2burkitt lymphoma30.9PAX5, BCR, BAX
3chronic lymphocytic leukemia30.9PAX5, BCR, BAX
4chronic myelomonocytic leukemia30.9BCR, FLT3
5hodgkin lymphoma30.8BCR, PAX5, FLT3
6acute lymphoblastic leukemia, childhood30.6FLT3, IKZF1, BCR, BAX
7precursor t-cell acute lymphoblastic leukemia30.4BAX, BCR, IKZF1, PAX5, FLT3, PICALM
8follicular lymphoma30.4BAX, BCR, PAX5
9acute leukemia30.3BCR, PAX5, FLT3
10myeloma30.2PAX5, BCR, BAX
11leukemia, chronic myeloid30.1FLT3, IKZF1, BCR
12leukemia30.0PICALM, FLT3, PAX5, TCF3, IKZF1, BCR
13b-cell lymphomas30.0FLT3, PAX5, IKZF1, BCR, BAX
14myeloid leukemia29.9PICALM, FLT3, BCR, BAX
15adult acute lymphocytic leukemia11.0
16lymphoblastic leukemia11.0
17lymphoblastic lymphoma10.9
18hematopoietic stem cell transplantation10.8
19childhood leukemia10.8
20glucocorticoid resistance10.8
21hypercalcemia10.7
22sarcoma10.7
23down syndrome10.7
24endotheliitis10.7
25wilms tumor10.6
26bone marrow necrosis10.6
27hemophagocytic lymphohistiocytosis10.6
28osteonecrosis10.6
29retinitis10.6
30obesity10.6
31hepatitis10.6
32neutropenia10.6
33eosinophilia10.6
34pancreatitis10.6
35breast cancer10.5
36ataxia-telangiectasia10.5
37hypertriglyceridemia10.5
38fusariosis10.5
39cerebritis10.5
40ataxia10.5
41histiocytic sarcoma10.5
42myelodysplastic syndrome10.5
43arthritis10.5
44hyperphosphatemia10.5
45influenza10.5
46meningitis10.5
47neuropathy10.5
48familial acute lymphocytic leukemia10.5
49myelofibrosis10.5
50severe congenital neutropenia10.5

Graphical network of the top 20 diseases related to Leukemia, Acute Lymphoblastic:



Diseases related to leukemia, acute lymphoblastic

Symptoms for Leukemia, Acute Lymphoblastic

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Clinical features from OMIM:

613065

HPO human phenotypes related to Leukemia, Acute Lymphoblastic:

id Description Frequency HPO Source Accession
1 acute lymphatic leukemia HP:0006721
2 polygenic inheritance HP:0010982

Drugs & Therapeutics for Leukemia, Acute Lymphoblastic

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Drug clinical trials:

Search ClinicalTrials for Leukemia, Acute Lymphoblastic

Search NIH Clinical Center for Leukemia, Acute Lymphoblastic

Inferred drug relations via UMLS60/NDF-RT39:

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Leukemia, Acute Lymphoblastic cell therapies at LifeMap Discovery.

Genetic Tests for Leukemia, Acute Lymphoblastic

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Anatomical Context for Leukemia, Acute Lymphoblastic

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MalaCards organs/tissues related to Leukemia, Acute Lymphoblastic:

31
Bone marrow, Bone, Monocytes, Skin, Testes, T cells, B cells, Myeloid

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Leukemia, Acute Lymphoblastic:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
2 BloodPeripheral BloodMature B-Cells Potential therapeutic candidate, affected by disease
3 BloodHematopoietic Bone MarrowSmall Pre B-Cells Potential therapeutic candidate, affected by disease

Animal Models for Leukemia, Acute Lymphoblastic or affiliated genes

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MGI Mouse Phenotypes related to Leukemia, Acute Lymphoblastic:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.4BCR, PAX5, BAX
2MP:00053977.3PICALM, BAX, BCR, IKZF1, TCF3, PAX5
3MP:00053877.3TCF3, IKZF1, BCR, BAX, PAX5, FLT3
4MP:00053847.2PICALM, FLT3, PAX5, TCF3, IKZF1, BCR
5MP:00053787.1PICALM, FLT3, PAX5, TCF3, IKZF1, BCR
6MP:00107686.9BCR, IKZF1, TCF3, PAX5, FLT3, PICALM

Publications for Leukemia, Acute Lymphoblastic

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Articles related to Leukemia, Acute Lymphoblastic:

idTitleAuthorsYear
1
Molecular analysis of the CALM/AF10 fusion: identical rearrangements in acute myeloid leukemia, acute lymphoblastic leukemia and malignant lymphoma patients. (10637482)
2000
2
Expression of MDR1 gene in acute leukemia cells: association with CD7+ acute myeloblastic leukemia/acute lymphoblastic leukemia. (7694687)
1993

Variations for Leukemia, Acute Lymphoblastic

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UniProtKB/Swiss-Prot genetic disease variations for Leukemia, Acute Lymphoblastic:

62
id Symbol AA change Variation ID SNP ID
1PAX5p.Gly183SerVAR_070682

Clinvar genetic disease variations for Leukemia, Acute Lymphoblastic:

6
id Gene Variation Type Significance SNP ID Assembly Location
1FLT3NM_004119.2(FLT3): c.2504A> T (p.Asp835Val)single nucleotide variantPathogenicrs121909646GRCh37Chr 13, 28592641: 28592641
2FLT3NM_004119.2(FLT3): c.2503G> T (p.Asp835Tyr)single nucleotide variantPathogenicrs121913488GRCh37Chr 13, 28592642: 28592642
3FLT3FLT3, 3-BP DEL, NT1777deletionPathogenic

Expression for genes affiliated with Leukemia, Acute Lymphoblastic

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Search GEO for disease gene expression data for Leukemia, Acute Lymphoblastic.

Pathways for genes affiliated with Leukemia, Acute Lymphoblastic

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Pathways related to Leukemia, Acute Lymphoblastic according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7BAX, FLT3
29.5TCF3, PAX5
39.4FLT3, BCR, BAX
49.1IKZF1, TCF3, PAX5
59.1TCF3, PAX5, FLT3

Compounds for genes affiliated with Leukemia, Acute Lymphoblastic

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Compounds related to Leukemia, Acute Lymphoblastic according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1homoharringtonine43 49 1212.0BAX, BCR
2ponatinib49 1210.8FLT3, BCR
32-methoxyestradiol43 59 2411.8BAX, PAX5
4gp 130439.7BCR, FLT3
5rituximab43 49 1211.7PAX5, BCR
6daunorubicin43 49 1211.6BAX, FLT3
7cytarabine43 49 1211.6BAX, BCR, FLT3
8leucine438.6BCR, IKZF1, PICALM

GO Terms for genes affiliated with Leukemia, Acute Lymphoblastic

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Biological processes related to Leukemia, Acute Lymphoblastic according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1retina development in camera-type eyeGO:00600419.8IKZF1, BAX
2peptidyl-tyrosine phosphorylationGO:00181089.7BCR, FLT3
3Peyers patch developmentGO:00485419.7IKZF1, TCF3
4natural killer cell differentiationGO:00017799.6IKZF1, TCF3
5regulation of cell cycleGO:00517269.5BAX, BCR
6B cell differentiationGO:00301839.3IKZF1, TCF3, FLT3
7hemopoiesisGO:00300979.1FLT3, PICALM

Molecular functions related to Leukemia, Acute Lymphoblastic according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein heterodimerization activityGO:00469829.3BAX, IKZF1, TCF3

Products for genes affiliated with Leukemia, Acute Lymphoblastic

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  • Antibodies
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  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Leukemia, Acute Lymphoblastic

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet