MCID: LKM062
MIFTS: 63

Leukemia, Acute Lymphoblastic

Categories: Genetic diseases, Rare diseases, Cancer diseases, Immune diseases, Blood diseases

Aliases & Classifications for Leukemia, Acute Lymphoblastic

MalaCards integrated aliases for Leukemia, Acute Lymphoblastic:

Name: Leukemia, Acute Lymphoblastic 54 71 13 13 13 13 38
Acute Lymphoblastic Leukemia 38 50 29
Leukemia, Acute Lymphoblastic, Susceptibility to, 3 29 69
Leukemia, Acute Lymphoblastic, Susceptibility to 29 13
T-Cell Acute Lymphoblastic Leukemia, Somatic 54 24
Acute Lymphocytic Leukemia 50 69
T-All 24 52
All 50 71
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma 69
Precursor Cell Lymphoblastic Leukemia Lymphoma 69
Leukemia, T-Cell Acute Lymphoblastic, Somatic 54
Leukemia, T-Cell Acute Lymphocytic, Somatic 54
Leukemia Acute Lymphoblastic B-Hyperdiploid 71
Leukemia, Acute Lymphoblastic, Somatic 54
Childhood Acute Lymphoblastic Leukemia 71
Acute Lymphoblastic Leukemia, Somatic 24
Leukemia, Acute Lymphocytic, Somatic 54
Leukemia, T-Cell Acute Lymphoblastic 13
Leukemia, Acute T-Cell Lymphoblastic 13
Leukemia B-Cell Acute Lymphoblastic 71
Leukemia T-Cell Acute Lymphoblastic 71
Leukemia, Acute Lymphoblastic, 3 71
Leukemia, Lymphocytic, Acute, L1 69
Leukemia Acute Lymphoblastic 1 71
Adult T-Cell Lymphoma/leukemia 69
Leukemia Acute Lymphocytic 1 71
Lymphoblastic Leukemia Acute 52
Leukemia, Acute Lymphocytic 13
Leukemia Acute Lymphocytic 71
All3 71
All1 71

Characteristics:

HPO:

32
leukemia, acute lymphoblastic:
Inheritance polygenic inheritance


Classifications:



External Ids:

OMIM 54 613065
MeSH 42 D054198
ICD10 33 C91.0
SNOMED-CT via HPO 65 128822004 91857003

Summaries for Leukemia, Acute Lymphoblastic

UniProtKB/Swiss-Prot : 71 Leukemia, acute lymphoblastic: A subtype of acute leukemia, a cancer of the white blood cells. ALL is a malignant disease of bone marrow and the most common malignancy diagnosed in children. The malignant cells are lymphoid precursor cells (lymphoblasts) that are arrested in an early stage of development. The lymphoblasts replace the normal marrow elements, resulting in a marked decrease in the production of normal blood cells. Consequently, anemia, thrombocytopenia, and neutropenia occur to varying degrees. The lymphoblasts also proliferate in organs other than the marrow, particularly the liver, spleen, and lymphnodes. Leukemia, acute lymphoblastic, 3: A subtype of acute leukemia, a cancer of the white blood cells. Acute lymphoblastic anemia is a malignant disease of bone marrow and the most common malignancy diagnosed in children. The malignant cells are lymphoid precursor cells (lymphoblasts) that are arrested in an early stage of development. The lymphoblasts replace the normal marrow elements, resulting in a marked decrease in the production of normal blood cells. Consequently, anemia, thrombocytopenia, and neutropenia occur to varying degrees. The lymphoblasts also proliferate in organs other than the marrow, particularly the liver, spleen, and lymphnodes.

MalaCards based summary : Leukemia, Acute Lymphoblastic, also known as acute lymphoblastic leukemia, is related to acute lymphoblastic leukemia, childhood and leukemia, acute myeloid, and has symptoms including acute lymphoblastic leukemia, angina pectoris and chest pain. An important gene associated with Leukemia, Acute Lymphoblastic is FLT3 (Fms Related Tyrosine Kinase 3), and among its related pathways/superpathways are NF-kappaB Signaling and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Arranon and Blincyto have been mentioned in the context of this disorder. Affiliated tissues include Blood and Blood, and related phenotypes are cellular and growth/size/body region

OMIM : 54
Acute lymphoblastic leukemia (ALL), also known as acute lymphocytic leukemia, is a subtype of acute leukemia, a cancer of the white blood cells. Somatically acquired mutations in several genes have been identified in ALL lymphoblasts, cells in the early stages of differentiation. Germline variation in certain genes may also predispose to susceptibility to ALL (Trevino et al., 2009). (613065)

Related Diseases for Leukemia, Acute Lymphoblastic

Diseases in the Lymphoblastic Leukemia family:

Leukemia, Acute Lymphoblastic 2 Leukemia, Acute Lymphoblastic
Leukemia, Acute Lymphoblastic 3

Diseases related to Leukemia, Acute Lymphoblastic via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
id Related Disease Score Top Affiliating Genes
1 acute lymphoblastic leukemia, childhood 34.6 ABCB1 ANPEP ETV6 FLT3 IL3 KMT2A
2 leukemia, acute myeloid 33.1 ANPEP ETV6 FLT3 IL3 KMT2A
3 b-cell childhood acute lymphoblastic leukemia 12.3
4 precursor t-cell acute lymphoblastic leukemia 12.2
5 leukemia, acute lymphoblastic 2 12.1
6 acute lymphoblastic leukemia congenital sporadic aniridia 12.0
7 leukemia, acute lymphoblastic 3 12.0
8 acute t cell leukemia 11.4
9 medulloblastoma 11.0
10 acute lymphocytic leukemia 11.0
11 lymphoma, small cleaved-cell, diffuse 10.9 BCR ETV6 KMT2A
12 ring chromosome 5 10.9 ETV6 KMT2A
13 acute necrotizing encephalopathy 10.9 ETV6 FLT3 KMT2A
14 cholesteatoma 10.9 ANPEP FLT3 KMT2A PAX5
15 nelson syndrome 10.9 ANPEP BCR ETV6 FLT3 IL3
16 hepatosplenic t-cell lymphoma 10.8 ETV6 MYB
17 acute monocytic leukemia 10.8 ABCB1 ETV6 FLT3
18 peroxisome biogenesis disorder 7a 10.8 ABCB1 BCR ETV6 FLT3 IL3 MYB
19 idiopathic syringomyelia 10.8 BCR FLT3 MYB PICALM TAL1 TRD
20 preeclampsia/eclampsia 3 10.8 ANPEP BCR ETV6 FLT3 KMT2A PAX5
21 spinocerebellar ataxia, autosomal recessive 21 10.8 ABCB1 ANPEP FLT3 IL3 KMT2A
22 cheek mucosa cancer 10.8 ABCB1 BCR ETV6 FLT3 IL3 NUP214
23 essential pentosuria 10.8 FLT3 KMT2A
24 smoking as a quantitative trait locus 1 10.8 ABCB1 BAX BCL10 BCR IL3 NBN
25 hemolytic anemia 10.8 ABCB1 BCR ETV6 FLT3 IL3 KMT2A
26 molybdenum cofactor deficiency 10.8 ETV6 FLT3
27 liver cirrhosis 10.7 BAX BCR ETV6 FLT3 TAL1 TAL2
28 acute myocardial infarction 10.7 ABCB1 ACTB BCR ETV6 NBN PAX5
29 suppression amblyopia 10.7 BAX BCR ETV6 FLT3 NBN PAX5
30 myelofibrosis with myeloid metaplasia, somatic 10.7 BCR FLT3 IL3
31 chronic myocardial ischemia 10.7 ABCB1 ANPEP BAX BCL10 BCR PAX5
32 seckel syndrome 10 10.6 BAX BCR PAX5
33 cranioectodermal dysplasia 1 10.6 ABCB1 ANPEP BCR ETV6 FLT3 IL3
34 acute pre-b-cell lymphoblastic leukemia 10.4 ETV6 FLT3
35 lymphoblastic leukemia 10.4
36 leukemia 10.4
37 peroxisome biogenesis disorder 5a 9.8 ABCB1 ACTB ANPEP BAX BCL10 BCR
38 lymphoma 9.6
39 childhood leukemia 9.6
40 myeloid leukemia 9.6
41 acute leukemia 9.6

Graphical network of the top 20 diseases related to Leukemia, Acute Lymphoblastic:



Diseases related to Leukemia, Acute Lymphoblastic

Symptoms & Phenotypes for Leukemia, Acute Lymphoblastic

Clinical features from OMIM:

613065

Human phenotypes related to Leukemia, Acute Lymphoblastic:

32
id Description HPO Frequency HPO Source Accession
1 acute lymphoblastic leukemia 32 HP:0006721

UMLS symptoms related to Leukemia, Acute Lymphoblastic:


angina pectoris, chest pain, edema

MGI Mouse Phenotypes related to Leukemia, Acute Lymphoblastic:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.29 BAX BCL10 BCR ETV6 FLT3 GNB1
2 growth/size/body region MP:0005378 10.22 BCR ETV6 FLT3 KMT2A MYB NBN
3 hematopoietic system MP:0005397 10.2 ABCB1 ACTB ANPEP BAX BCL10 BCR
4 embryo MP:0005380 10.16 ACTB BCL10 ETV6 GNB1 KMT2A MYB
5 immune system MP:0005387 10.1 PICALM TAL1 ABCB1 ACTB ANPEP BAX
6 endocrine/exocrine gland MP:0005379 10.09 ACTB ANPEP BAX BCL10 ETV6 FLT3
7 mortality/aging MP:0010768 10.06 ABCB1 ACTB BAX BCL10 BCR ETV6
8 hearing/vestibular/ear MP:0005377 9.85 ABCB1 ACTB BAX BCR KMT2A PAX5
9 neoplasm MP:0002006 9.5 ACTB BAX ETV6 FLT3 KMT2A NBN
10 nervous system MP:0003631 9.36 ABCB1 ACTB BAX BCL10 BCR GNB1

Drugs & Therapeutics for Leukemia, Acute Lymphoblastic

FDA approved drugs:

(show all 7)
id Drug Name Active Ingredient(s) 17 Company Approval Date
1
Arranon 17 46 NELARABINE GlaxoSmithKline October 2005
2
Blincyto 17 46 BLINATUMOMAB Amgen December 2014
3
Clolar 17 46 CLOFARABINE Genzyme December, 2004
4
Erwinaze 17 46 asparaginase Erwinia chrysanthemi Eusa Pharma November of 2011
5
Iclusig 17 46 PONATINIB HYDROCHLORIDE Ariad Pharmaceuticals December 2012
6
Marqibo 17 46 VINCRISTINE SULFATE Talon Therapeutics August 2012
7
Sprycel 17 46 DASATINIB Bristol-Myers Squibb June 2006

Drugs for Leukemia, Acute Lymphoblastic (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 615)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Asparaginase Approved Phase 4,Phase 3,Phase 2,Phase 1 9015-68-3
2
Cytarabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 147-94-4 6253
3
Daunorubicin Approved Phase 4,Phase 3,Phase 2,Phase 1 20830-81-3 30323
4
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-02-2 5743
5
Idarubicin Approved Phase 4,Phase 3,Phase 2,Phase 1 58957-92-9 42890
6
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 1959-05-2, 59-05-2 126941
7
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 2068-78-2, 57-22-7 5978
8
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-18-0, 6055-19-2 2907
9
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 23214-92-8 31703
10
Pegaspargase Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 130167-69-0
11
Lenograstim Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 135968-09-1
12
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
13
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
14
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1 174722-31-7 10201696
15
Cladribine Approved, Investigational Phase 4,Phase 2,Phase 1 4291-63-8 20279
16
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 33419-42-0 36462
17
Fludarabine Approved Phase 4,Phase 3,Phase 2,Phase 1 21679-14-1, 75607-67-9 30751
18
Teniposide Approved Phase 4,Phase 3,Phase 2 29767-20-2 34698
19
Thioguanine Approved Phase 4,Phase 3,Phase 2,Phase 1 154-42-7 2723601
20
Vindesine Approved Phase 4,Phase 3,Phase 2 59917-39-4, 53643-48-4 40839
21
Ifosfamide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 3778-73-2 3690
22
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 53-03-2 5865
23
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-23-7 5754 657311
24
Mitoxantrone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 65271-80-9 4212
25 Thiotepa Approved Phase 4,Phase 3,Phase 2,Phase 1 52-24-4 5453
26
Busulfan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 55-98-1 2478
27
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
28
Dasatinib Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 302962-49-8 3062316
29
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
30
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
31
Oprelvekin Approved, Investigational Phase 4 145941-26-0
32
Menthol Approved Phase 4 2216-51-5 16666
33
Micafungin Approved, Investigational Phase 4,Phase 2 235114-32-6 3081921 477468
34
Posaconazole Approved, Investigational, Vet_approved Phase 4 171228-49-2 147912
35
Amphotericin B Approved, Investigational Phase 4,Phase 3,Phase 2 1397-89-3 14956 5280965
36
Nicotine Approved Phase 4 54-11-5 942 89594
37
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 59-30-3 6037
38
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 58-05-9 143 6006
39
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2 50-14-6 5280793
40
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 1406-16-2
41
Cholecalciferol Approved, Nutraceutical Phase 4 67-97-0 6221 10883523 5280795
42
Doxil Approved June 1999 Phase 4,Phase 3,Phase 2,Phase 1 31703
43
Butyric Acid Experimental Phase 4,Phase 3,Phase 2,Phase 1 107-92-6 264
44
Treosulfan Investigational Phase 4,Phase 3,Phase 2,Phase 1 299-75-2 9296
45 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
46 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1
47 BB 1101 Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
48 Dexamethasone acetate Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 1177-87-3
49 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
50 6-Mercaptopurine Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 1689)

id Name Status NCT ID Phase Drugs
1 Treatment Protocol of Children With Philadelphia Chromosome Negative High Risk Acute Lymphoblastic Leukemia Unknown status NCT01990807 Phase 4 Idarubicin(IDA)
2 Medical Research Council (MRC) Working Party on Leukaemia in Children UK National Acute Lymphoblastic Leukaemia (ALL) Trial: UKALL 2003 Unknown status NCT00222612 Phase 4 Standard childhood UK ALL protocol;Intensified treatment including Capizzi maintenance
3 German Multicenter Trial for Treatment of Elderly Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Unknown status NCT00198978 Phase 4 Cyclophosphamide;Dexamethasone / Prednisolone;Cytarabine;Idarubicin;Granulocyte-Colony-Stimulating Factor;Mercaptopurine;Methotrexate;Rituximab;HDARAC;Vincristine;Depocyte;Asparaginase
4 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (07/2003) Unknown status NCT00198991 Phase 4 Cyclophosphamide;Dexamethasone;Vincristine;daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Prednisolone;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Cladribine
5 Poly(Ethylene Glycol)(PEG)-Asparaginase During Two Treatment Courses Unknown status NCT00192673 Phase 4 PEG-asparaginase
6 HD-Idarubicin/Etoposide Intensified Conditioning Regimen Allo-HSCT for Adult ALL Unknown status NCT01873807 Phase 4 IDA;CTX;VP-16
7 Intensification Therapy of Mature B-ALL, Burkitt and Burkitt Like and Other High Grade Non-Hodgkin's Lymphoma in Adults Unknown status NCT00797810 Phase 4 Rituximab
8 ATG Could Improve the Outcome Of Hematopoietic Stem Cell Transplant in Patients With Highly Aggressive T Cell Tumors Unknown status NCT02290132 Phase 4 Rabbit Anti-human Thymocyte Globulin (ATG)
9 Assessment Of Gh-Igf-1 Axis In Children With Chronic Myelogenous Leukemia (CML) In Remission Unknown status NCT01901666 Phase 4 Growth Hormone
10 Pulses of Vincristine and Dexamethasone in BFM Protocols for Children With Acute Lymphoblastic Leukemia Completed NCT00411541 Phase 4 vincristine;dexamethasone
11 LAL-AR-N-2005:Study Treatment for Children High Risk Acute Lymphoblastic Leukemia Completed NCT00526409 Phase 4 Prednisolone;Daunorubicin;Vincristine;L-Asparaginase;Cyclophosphamide;Methotrexate;Cytosine Arabinoside
12 Rituximab Plus Chemotherapy for CD20+ Adult Acute Lymphoblastic Leukemia Completed NCT01358253 Phase 4 Cyclophosphamide;Doxorubicin;Vincristine;Dexamethasone;Cytarabine;Methotrexate;Rituximab;6-Mercaptopurine;Prednisone;L-asparaginase
13 PETHEMA LAL-RI/96: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia Completed NCT00494897 Phase 4 Asparaginase;Cyclophosphamide;Cytarabine;Daunorubicin;Mercaptopurine;Prednisone;Vincristine;Methotrexate
14 Treatment of Elderly Patients (>65 Years) With Acute Lymphoblastic Leukemia Completed NCT00199095 Phase 4 Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone;Idarubicin;Ifosfamide;Methotrexate;Mercaptopurine;VM26;Vincristine
15 LAL-Ph-2000: Treatment of Acute Lymphoblastic Leukemia Chromosome Philadelphia Positive Completed NCT00526305 Phase 4 Vincristine;Daunorubicin;Prednisone;L-Asparaginase;Mitoxantrone;Cytosine Arabinoside;Hydrocortisone;Mercaptopurine;Cyclophosphamide;Dexamethasone
16 ALL-REZ BFM 2002: Multi-Center Study for Children With Relapsed Acute Lymphoblastic Leukemia Completed NCT00114348 Phase 4
17 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (05/93) Completed NCT00199069 Phase 4 Asparaginase;Vincristine;Daunorubicin, Adriamycin;Cyclophosphamide;Ifosfamide;Cytarabine;Mitoxantrone;Methotrexate;6-Mercaptopurine;6-Thioguanine;VM26;Dexamethasone / Prednisolone
18 Trial for Treatment of Adult Patients With Standard Risk Acute Lymphoblastic Leukemia With Chemotherapy and Rituximab Completed NCT00199004 Phase 4 Cyclophosphamide;Dexamethasone / Prednisolone;Vincristine;Daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Adriamycin;Thioguanine;VM26;Rituximab
19 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (06/99) Completed NCT00199056 Phase 4 Dexamethasone / Prednisolone;Cyclophosphamide;Methotrexate;Vincristine / Vindesine;Daunorubicin;Asparaginase;G-CSF;Cytarabine;6-Mercaptopurine;VP16;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Ifosfamide
20 Learning Impairments Among Survivors of Childhood Cancer Completed NCT00576472 Phase 4 Methylphenidate
21 LAL-BR/2001: Study Treatment to Low Risk ALL Completed NCT00526175 Phase 4 Prednisone;Vincristine;Daunorubicin;L-Asparaginase;Cyclophosphamide;Methotrexate;Cytosine Arabinoside;Mercaptopurine;VP-16
22 Effect of rhIL-11 in Patients With Thrombocytopenia for Childhood ALL Completed NCT02314273 Phase 4 rhIL-11
23 The Study on the Pharmacokinetics of PEG-rhG-CSF in Children and Adolescents Completed NCT02953730 Phase 4 PEG-rhG-CSF
24 Trial for the Treatment of Newly Diagnosed Mature B-Cell Acute Lymphoblastic Leukemia (B-ALL), Burkitt's Non-Hodgkin's Lymphoma (NHL) and Other High-grade Lymphoma in Adults Completed NCT00199082 Phase 4 Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone/Prednisolone;VP16;Ifosfamide;Methotrexate;G-CSF;Rituximab;Vincristine/Vindesine
25 German Multicenter Trial for the Treatment of Newly Diagnosed T-lymphoblastic Lymphoma in Adults Completed NCT00199017 Phase 4 Dexamethasone/Prednisolone;Cyclophosphamide;Vincristine;Daunorubicin;Asparaginase;G-CSF;Mercaptopurine;Cytarabine;Methotrexate;VP16;Vindesine;Adriamycin;Thioguanine;HDARAC;Cladribine
26 Bone Marrow Transplantation in Treating Patients With Hematologic Cancer Completed NCT00003398 Phase 4 cyclophosphamide;thiotepa
27 Identification of New Immune Factors Specific of Relapse in Childhood B Lineage Acute Lymphoblastic Leukemia Recruiting NCT02618109 Phase 4
28 The GD-2008 ALL Protocol for Childhood Acute Lymphoblastic Leukemia Recruiting NCT00846703 Phase 4 6-mercaptopurine, Methotrexate;6-mercaptopurine, Methotrexate, Vincristine, Dexamethasone
29 Protocol For the Treatment Acute Lymphoblastic Leukemia With Ph 'Negative in Elderly Patients (> 55 Years) Recruiting NCT01366898 Phase 4 Dexamethasona, Idarubicine, ARA-C, Methotrexate
30 Treatment of Acute Lymphoblastic Leukemia HIGH RISK BCR / ABL NEGATIVE IN ADULTS Recruiting NCT01540812 Phase 4 Vincristine in induction;Daunorubicin in induction;Prednisone in induction;Metotrexato in induction;Cytarabine in induction;Hydrocortisone in induction;Idarubicin in induction-2;Fludarabine in induction-2;Ara-C in induction-2;G-CSF in induction-2;Dexamethasone in consolidation-1;Vincristrine in consolidation-1;Metotrexato in consolidation-1;PEG-ASP in consolidation-1;Dexamethasone in consolidation-2;ARA-C in consolidation-2;PEG-ASP in consolidation-2;Dexamethasone in consolidation-3;Vincristine in consolidation-3;Metotrexato in consolidation-3;PEG-ASP in consolidation-3
31 Malaysia-Singapore Acute Lymphoblastic Leukemia 2010 Study Recruiting NCT02894645 Phase 4 Prednisolone;Dexamethasone;L-Asparaginase;Vincristine;Methotrexate;Daunorubicin;Doxorubicin;Cyclophosphamide;Cytarabine;6-Mercaptopurine;Thioguanine;Fludarabine;Imatinib
32 Chemotherapy and Imatinib in Young Adults With Acute Lymphoblastic Leukemia Ph (BCR-ABL) POSITIVE Recruiting NCT01491763 Phase 4 Imatinib
33 Study on Two Different Formulations of 6-mercaptopurine. Tablet Versus Oral Liquid Recruiting NCT01906671 Phase 4 Xaluprine;Puri-Nethol
34 PETHEMA LAL-07FRAIL: All Treatment In Fragile Patients Ph' Negative Over 55 Years Recruiting NCT01358201 Phase 4 vINCRISTINE;Dexamethasone;Methotrexate;Cytosine arabinoside
35 Vaccinating Children After Chemotherapy Recruiting NCT02447718 Phase 4
36 ALL SCTped FORUM - Pharmacogenomic Study (add-on Study) Recruiting NCT02670564 Phase 4
37 Pethema LAL-RI/2008: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia Recruiting NCT02036489 Phase 4 Vincristine;Daunorubicin;Prednisone;L-asparaginase;Ciclophosphamide;Metotrexate;ARA-C;Hidrocortisone;Mercaptopurine;VP-16;Dexametasone
38 ATG Based Conditioning Regimen in HLA Related HSCT for Aggressive T-cell Tumors Recruiting NCT02938741 Phase 4 Anti-human Thymoglobulin;Placebo
39 Treatment of High Risk Adult Acute Lymphoblastic Leukemia Active, not recruiting NCT00853008 Phase 4 Vincristine;Daunorubicin;Prednisone;Mitoxantrone;Cytosine Arabinoside;Dexamethasone;Methotrexate (MTX);Cytarabine;ASP;Mercaptopurine;Teniposide;Hydrocortisone
40 Posaconazole Versus Micafungin for Prophylaxis Against Invasive Fungal Infections During Neutropenia in Patients Undergoing Chemotherapy for Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia or Myelodysplastic Syndrome Active, not recruiting NCT01200355 Phase 4 micafungin;posaconazole
41 Low-dose Chemotherapy Combine With Tyrosine Kinase Inhibitor to Treat ph+ Acute Lymphoblastic Leukemia Patients Not yet recruiting NCT02690922 Phase 4 Dasatinib;prednisone;dexamethasone;methotrexate
42 G-CSF Alone or Combination With GM-CSF on Prevention and Treatment of Infection in Children With Malignant Tumor Not yet recruiting NCT02933333 Phase 4
43 A Randomized Phase IV Control Trial of Single High Dose Oral Vitamin D3 in Pediatric Patients Undergoing HSCT Not yet recruiting NCT03176849 Phase 4
44 ProphyALL - Study on the Safety of Liposomal Amphotericin B to Prevent Antifungal Infections in Elderly Patients With Acute Lymphoblastic Leukemia Terminated NCT00386997 Phase 4 liposomal amphotericin B (AmBisome®)
45 Atomoxetine for Children With Acquired Attentional Disorders Following Completion of Chemotherapy for ALL Terminated NCT00299234 Phase 4 Atomoxetine
46 Phase III Study of Vincristine Sulfate Liposome For Injection In Adults With Naïve Acute Lymphoblastic Leukemia Unknown status NCT02072785 Phase 3 Vincristine Sulfate Liposome;Vincristine Sulfate
47 High-Dose Methotrexate (MTX) for Adult Acute Lymphoblastic Leukemia (ALL) Unknown status NCT00131027 Phase 3 Cyclophosphamide;Daunorubicin;Vincristine;Prednisolone;L-asparaginase;Cytarabine;Etoposide;Dexamethasone;Methotrexate;Mercaptopurine;Doxorubicin;Methotrexate
48 Treatment of Acute Lymphoblastic Leukemia or Aggressive Lymphoma With Relapse in Central Nervous System With Depocyt Unknown status NCT00199108 Phase 2, Phase 3 Depocyt;Dexamethasone
49 Hormone Therapy Plus Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia Unknown status NCT00003437 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;mercaptopurine;methotrexate;pegaspargase;prednisolone;thioguanine;vincristine sulfate
50 Risk-Adjusted Combination Chemotherapy in Treating Young Patients With Acute Lymphoblastic Leukemia Unknown status NCT00764907 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;ifosfamide;leucovorin calcium;mercaptopurine;methotrexate;prednisone;thioguanine;vincristine sulfate;vindesine

Search NIH Clinical Center for Leukemia, Acute Lymphoblastic

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Leukemia, Acute Lymphoblastic cell therapies at LifeMap Discovery.

Genetic Tests for Leukemia, Acute Lymphoblastic

Genetic tests related to Leukemia, Acute Lymphoblastic:

id Genetic test Affiliating Genes
1 Leukemia, Acute Lymphoblastic, Susceptibility to, 3 29
2 Leukemia, Acute Lymphoblastic, Susceptibility to 29
3 Acute Lymphoblastic Leukemia 29
4 T-Cell Acute Lymphoblastic Leukemia, Somatic 24 MYB
5 Acute Lymphoblastic Leukemia, Somatic 24 BCR

Anatomical Context for Leukemia, Acute Lymphoblastic

MalaCards organs/tissues related to Leukemia, Acute Lymphoblastic:

39
T Cells, Bone, Bone Marrow, B Cells, Myeloid, Liver, Kidney
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Leukemia, Acute Lymphoblastic:
id Tissue Anatomical CompartmentCell Relevance
1 Blood Hematopoietic Bone Marrow Hematopoietic Stem Cells Potential therapeutic candidate
2 Blood Peripheral Blood Mature B-Cells Affected by disease
3 Blood Hematopoietic Bone Marrow Small Pre B-Cells Affected by disease

Publications for Leukemia, Acute Lymphoblastic

Articles related to Leukemia, Acute Lymphoblastic:

id Title Authors Year
1
Molecular analysis of the CALM/AF10 fusion: identical rearrangements in acute myeloid leukemia, acute lymphoblastic leukemia and malignant lymphoma patients. ( 10637482 )
2000
2
Expression of MDR1 gene in acute leukemia cells: association with CD7+ acute myeloblastic leukemia/acute lymphoblastic leukemia. ( 7694687 )
1993

Variations for Leukemia, Acute Lymphoblastic

UniProtKB/Swiss-Prot genetic disease variations for Leukemia, Acute Lymphoblastic:

71
id Symbol AA change Variation ID SNP ID
1 PAX5 p.Gly183Ser VAR_070682 rs398123063

ClinVar genetic disease variations for Leukemia, Acute Lymphoblastic:

6 (show all 13)
id Gene Variation Type Significance SNP ID Assembly Location
1 BCL10 NM_003921.4(BCL10): c.136_137insA (p.Ile46Asnfs) insertion Pathogenic rs387906351 GRCh37 Chromosome 1, 85736511: 85736511
2 NBN NM_002485.4(NBN): c.511A> G (p.Ile171Val) single nucleotide variant risk factor rs61754966 GRCh37 Chromosome 8, 90990521: 90990521
3 BAX NM_138761.3(BAX): c.199G> A (p.Gly67Arg) single nucleotide variant Pathogenic rs398122513 GRCh37 Chromosome 19, 49459056: 49459056
4 BAX NM_138761.3(BAX): c.115_121delGGGGGGG (p.Gly39Argfs) deletion Pathogenic rs398122842 GRCh37 Chromosome 19, 49458972: 49458978
5 FLT3 NM_004119.2(FLT3): c.2504A> T (p.Asp835Val) single nucleotide variant Pathogenic rs121909646 GRCh37 Chromosome 13, 28592641: 28592641
6 FLT3 NM_004119.2(FLT3): c.2503G> T (p.Asp835Tyr) single nucleotide variant Pathogenic rs121913488 GRCh37 Chromosome 13, 28592642: 28592642
7 FLT3 NM_004119.2(FLT3): c.1777_1779delGAT (p.Asp593del) deletion Pathogenic rs587776834 GRCh38 Chromosome 13, 28034140: 28034142
8 ETV6 NM_001987.4(ETV6): c.1153-5_1153-1delAACAG deletion Pathogenic rs786205154 GRCh37 Chromosome 12, 12038855: 12038859
9 ETV6 NM_001987.4(ETV6): c.1046T> C (p.Leu349Pro) single nucleotide variant Pathogenic rs786205155 GRCh37 Chromosome 12, 12037415: 12037415
10 ACTB NP_001092.1(ACTB): p.Val209Leu protein only Pathogenic
11 GNB1 NM_002074.4(GNB1): c.239T> A (p.Ile80Asn) single nucleotide variant Pathogenic rs752746786 GRCh37 Chromosome 1, 1737942: 1737942
12 GNB1 NM_002074.4(GNB1): c.227A> G (p.Asp76Gly) single nucleotide variant Pathogenic rs869312821 GRCh38 Chromosome 1, 1806515: 1806515
13 NBN NM_002485.4(NBN): c.156_157delTT (p.Ser53Cysfs) deletion Pathogenic/Likely pathogenic rs767454740 GRCh38 Chromosome 8, 89982736: 89982737

Copy number variations for Leukemia, Acute Lymphoblastic from CNVD:

7 (show top 50) (show all 2943)
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 13316 1 1 117600000 Loss Acute lymphoblastic leukemia
2 13371 17 1 22200000 Deletion TP53 Acute lymphoblastic leukemia
3 13410 1 1 2300000 Copy number Acute lymphoblastic leukemia
4 13773 1 1 35400000 Duplication Acute lymphoblastic leukemia
5 13788 1 1 40300000 Duplication Acute lymphoblastic leukemia
6 13790 1 1 46500000 Gain Acute lymphoblastic leukemia
7 13836 12 10000000 12600000 Deletion ETV6 Acute lymphoblastic leukemia
8 13906 1 100818677 103024856 Loss DPH5 Acute lymphoblastic leukemia
9 13907 1 100818677 103024856 Loss EXTL2 Acute lymphoblastic leukemia
10 13908 1 100818677 103024856 Loss OLFM3 Acute lymphoblastic leukemia
11 13909 1 100818677 103024856 Loss S1PR1 Acute lymphoblastic leukemia
12 13910 1 100818677 103024856 Loss SLC30A7 Acute lymphoblastic leukemia
13 13911 1 100818677 103024856 Loss VCAM1 Acute lymphoblastic leukemia
14 13991 1 102370195 102561809 Deletion Acute lymphoblastic leukemia
15 14292 1 106673274 107678605 Loss NTNG1 Acute lymphoblastic leukemia
16 14293 1 106673274 107678605 Loss PRMT6 Acute lymphoblastic leukemia
17 14369 1 107716342 144004701 Loss ADAM30 Acute lymphoblastic leukemia
18 14370 1 107716342 144004701 Loss ADORA3 Acute lymphoblastic leukemia
19 14371 1 107716342 144004701 Loss AFARP1 Acute lymphoblastic leukemia
20 14372 1 107716342 144004701 Loss AHCYL1 Acute lymphoblastic leukemia
21 14373 1 107716342 144004701 Loss AKNAD1 Acute lymphoblastic leukemia
22 14374 1 107716342 144004701 Loss ALX3 Acute lymphoblastic leukemia
23 14375 1 107716342 144004701 Loss AMIGO1 Acute lymphoblastic leukemia
24 14376 1 107716342 144004701 Loss AMPD1 Acute lymphoblastic leukemia
25 14377 1 107716342 144004701 Loss AMPD2 Acute lymphoblastic leukemia
26 14378 1 107716342 144004701 Loss AP4B1 Acute lymphoblastic leukemia
27 14379 1 107716342 144004701 Loss ATP1A1 Acute lymphoblastic leukemia
28 14380 1 107716342 144004701 Loss ATP5F1 Acute lymphoblastic leukemia
29 14381 1 107716342 144004701 Loss ATXN7L2 Acute lymphoblastic leukemia
30 14382 1 107716342 144004701 Loss BCAS2 Acute lymphoblastic leukemia
31 14383 1 107716342 144004701 Loss BCL2L15 Acute lymphoblastic leukemia
32 14384 1 107716342 144004701 Loss C1orf103 Acute lymphoblastic leukemia
33 14385 1 107716342 144004701 Loss C1orf152 Acute lymphoblastic leukemia
34 14386 1 107716342 144004701 Loss C1orf161 Acute lymphoblastic leukemia
35 14387 1 107716342 144004701 Loss C1orf162 Acute lymphoblastic leukemia
36 14388 1 107716342 144004701 Loss C1orf183 Acute lymphoblastic leukemia
37 15383 1 115048600 115061038 Copy number NRAS Acute lymphoblastic leukemia
38 15429 1 115400000 222100000 Gain Acute lymphoblastic leukemia
39 15832 1 119869201 120436800 Loss HMGCS2 Acute lymphoblastic leukemia
40 15833 1 119869201 120436800 Loss NBPF7 Acute lymphoblastic leukemia
41 15834 1 119869201 120436800 Loss NOTCH2 Acute lymphoblastic leukemia
42 15835 1 119869201 120436800 Loss PHGDH Acute lymphoblastic leukemia
43 15836 1 119869201 120436800 Loss REG4 Acute lymphoblastic leukemia
44 15837 1 119869201 120436800 Loss ZNF697 Acute lymphoblastic leukemia
45 15979 1 120700000 169100000 Loss CREG1 Acute lymphoblastic leukemia
46 16426 1 124300000 247249719 Deletion Acute lymphoblastic leukemia
47 16427 1 124300000 247249719 Duplication Acute lymphoblastic leukemia
48 16474 1 125000000 249250621 Copy number Acute lymphoblastic leukemia
49 16502 1 12600000 16100000 Deletion Acute lymphoblastic leukemia
50 16592 1 128000000 185104377 Copy number Acute lymphoblastic leukemia

Expression for Leukemia, Acute Lymphoblastic

Search GEO for disease gene expression data for Leukemia, Acute Lymphoblastic.

Pathways for Leukemia, Acute Lymphoblastic

Pathways related to Leukemia, Acute Lymphoblastic according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.85 BCL10 IL3 MYB PAX5 TAL1
2 11.61 ANPEP FLT3 IL3
3 11.48 ANPEP FLT3 IL3
4 11.36 BAX ETV6 FLT3 IL3 KMT2A PAX5
5 11.32 ANPEP MYB PAX5
6 10.16 ABCB1 BAX

GO Terms for Leukemia, Acute Lymphoblastic

Cellular components related to Leukemia, Acute Lymphoblastic according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.93 ACTB BAX BCL10 BCR ETV6 FLT3
2 nucleus GO:0005634 9.44 ANPEP BAX BCL10 ETV6 FLT3 KMT2A
3 protein complex GO:0043234 9.35 ACTB BCL10 BCR FLT3 TAL1

Biological processes related to Leukemia, Acute Lymphoblastic according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.83 BCL10 KMT2A MYB PICALM TAL1
2 post-embryonic development GO:0009791 9.54 BAX KMT2A TAL2
3 hemopoiesis GO:0030097 9.5 FLT3 PICALM TAL1
4 homeostasis of number of cells GO:0048872 9.46 BAX BCR
5 positive regulation of histone H3-K4 methylation GO:0051571 9.4 KMT2A MYB
6 B cell apoptotic process GO:0001783 9.26 BAX BCL10
7 leukocyte homeostasis GO:0001776 9.16 BAX FLT3
8 definitive hemopoiesis GO:0060216 9.13 BCR KMT2A TAL1
9 embryonic hemopoiesis GO:0035162 8.8 IL3 KMT2A TAL1

Molecular functions related to Leukemia, Acute Lymphoblastic according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0000981 8.92 ETV6 MYB TAL1 TAL2

Sources for Leukemia, Acute Lymphoblastic

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
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36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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