Leukemia, Acute Promyelocytic, Somatic malady
Categories: Genetic diseases, Rare diseases, Cancer diseases, Blood diseases, Immune diseases
50OMIM, 24Genetics Home Reference, 12diseasecard, 11Disease Ontology, 46NIH Rare Diseases, 23GeneTests, 13DISEASES, 52Orphanet, 25GTR, 66UMLS, 48Novoseek, 37MeSH, 28ICD10, 43NCIt, 29ICD10 via Orphanet, 38MESH via Orphanet, 67UMLS via Orphanet, 60SNOMED-CT, 62The Human Phenotype Ontology
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Aliases & Descriptions for Leukemia, Acute Promyelocytic, Somatic:
Orphanet epidemiological data:52
acute promyelocytic leukemia:
Prevalence: 1-9/1000000 (United States),1-9/1000000 (Europe),1-9/1000000 (France); Age of onset: Adult; Age of death: elderly
leukemia, acute promyelocytic, somatic:
Inheritance: somatic mutation
Global: Genetic diseases, Rare diseases, Cancer diseases
Anatomical: Blood diseases, Immune diseases
ICD10: 29 28
Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
Rare haematological diseases
OMIM:50 The PML tumor suppressor protein is essential for the formation of a dynamic macromolecular nuclear structure called... (102578) more...
MalaCards based summary: Leukemia, Acute Promyelocytic, Somatic, also known as acute promyelocytic leukemia, is related to acute myelomonocytic leukemia and acute promyelocytic leukemia numa/rara type, and has symptoms including acute promyelocytic leukemia and abnormality of cells of the granulocytic lineage. An important gene associated with Leukemia, Acute Promyelocytic, Somatic is STAT5B (Signal Transducer And Activator Of Transcription 5B), and among its related pathways are Proteolysis Putative SUMO-1 pathway and Androgen receptor signaling pathway. The drugs tretinoin and arsenic trioxide have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone marrow and bone, and related mouse phenotypes are neoplasm and immune system.
Disease Ontology:11 An acute myeloid leukemia characterized by accumulation of promyelocytes in the bone marrow and by a translocation between chromosomes 15 and 17.
Genetics Home Reference:24 Acute promyelocytic leukemia is a form of acute myeloid leukemia, a cancer of the blood-forming tissue (bone marrow). In normal bone marrow, hematopoietic stem cells produce red blood cells (erythrocytes) that carry oxygen, white blood cells (leukocytes) that protect the body from infection, and platelets (thrombocytes) that are involved in blood clotting. In acute promyelocytic leukemia, immature white blood cells called promyelocytes accumulate in the bone marrow. The overgrowth of promyelocytes leads to a shortage of normal white and red blood cells and platelets in the body, which causes many of the signs and symptoms of the condition.
NIH Rare Diseases:46 Acute promyelocytic leukemia is an aggressive type of acute myeloid leukemia in which there are too many immature blood-forming cells in the blood and bone marrow. it is usually marked by a translocation of chromosomes 15 and 17. acute promyelocytic leukemia usually occurs in middle-aged adults. symptoms may include both bleeding and forming blood clots. last updated: 6/23/2011
Description from OMIM:50 612376
FDA approved drugs:
Drugs for Leukemia, Acute Promyelocytic, Somatic (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):(show top 50) (show all 99)
Interventional clinical trials:(show top 50) (show all 156)
Search NIH Clinical Center for Leukemia, Acute Promyelocytic, Somatic
Inferred drug relations via UMLS66/NDF-RT44:
MalaCards organs/tissues related to Leukemia, Acute Promyelocytic, Somatic:34
Myeloid, Bone marrow, Bone, Lung, Testes, Prostate
MGI Mouse Phenotypes related to Leukemia, Acute Promyelocytic, Somatic:39
Copy number variations for Leukemia, Acute Promyelocytic, Somatic from CNVD:6 (show all 28)
Search GEO for disease gene expression data for Leukemia, Acute Promyelocytic, Somatic.
Pathways related to Leukemia, Acute Promyelocytic, Somatic according to GeneCards Suite gene sharing:
Cellular components related to Leukemia, Acute Promyelocytic, Somatic according to GeneCards Suite gene sharing:
Biological processes related to Leukemia, Acute Promyelocytic, Somatic according to GeneCards Suite gene sharing:(show all 13)
Molecular functions related to Leukemia, Acute Promyelocytic, Somatic according to GeneCards Suite gene sharing:(show all 7)
29ICD10 via Orphanet
38MESH via Orphanet
51OMIM via Orphanet
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
67UMLS via Orphanet