MCID: LKM063
MIFTS: 53

Leukemia, Chronic Myeloid malady

Genetic diseases, Rare diseases, Blood diseases, Cancer diseases, Immune diseases categories

Aliases & Classifications for Leukemia, Chronic Myeloid

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Sources:
45OMIM, 30LifeMap Discovery®, 9Disease Ontology, 10diseasecard, 41NIH Rare Diseases, 11DISEASES, 43Novoseek, 47Orphanet, 22GTR, 32MedlinePlus, 60UMLS, 33MeSH, 55SNOMED-CT, 27ICD9CM, 38NCIt, 26ICD10 via Orphanet, 61UMLS via Orphanet
See all sources

Leukemia, Chronic Myeloid, Aliases & Descriptions:

Name: Leukemia, Chronic Myeloid 45 10 41 30
Chronic Myeloid Leukemia 30 9 41 11 47 32
Chronic Granulocytic Leukemia 9 41 47
Chronic Myelogenous Leukemia 9 41 47
 
Myeloid Leukemia, Chronic 9 60
Myeloid Leukemia Chronic 43 22
Cml 9 41
Cml - Chronic Myelogenous Leukemia 9


Classifications:



Characteristics (Orphanet epidemiological data):

47
chronic myeloid leukemia:
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe),1-9/100000 (France); Age of onset: Adult


External Ids:

OMIM45 608232
Disease Ontology9 DOID:8552
MeSH33 D015464
ICD9CM27 205.1
NCIt38 C3174
Orphanet47 521
ICD10 via Orphanet26 C92.1
UMLS via Orphanet61 C0023473

Summaries for Leukemia, Chronic Myeloid

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MedlinePlus:32 Leukemia is cancer of the white blood cells. white blood cells help your body fight infection. your blood cells form in your bone marrow. in leukemia, the bone marrow produces abnormal white blood cells. these cells crowd out the healthy blood cells, making it hard for blood to do its work. in chronic myeloid leukemia (cml), there are too many granulocytes, a type of white blood cell. most people with cml have a gene mutation (change) called the philadelphia chromosome. sometimes cml does not cause any symptoms. if you have symptoms, they may include: fatigue weight loss night sweats fever pain or a feeling of fullness below the ribs on the left side tests that examine the blood and bone marrow diagnose cml. treatments include chemotherapy, stem cell transplants, infusion of donated white blood cells following stem cell transplants, surgery to remove the spleen, and biologic and targeted therapies. biologic therapy boosts your body's own ability to fight cancer. targeted therapy uses substances that attack cancer cells without harming normal cells. nih: national cancer institute

MalaCards based summary: Leukemia, Chronic Myeloid, also known as chronic myeloid leukemia, is related to chronic myelomonocytic leukemia and myelodysplastic syndrome, and has symptoms including somatic mutation, ph-positive acute lymphoblastic leukemia and chronic myelogenous leukemia. An important gene associated with Leukemia, Chronic Myeloid is BCR (breakpoint cluster region), and among its related pathways are Tyrosine Kinases / Adaptors and Gefitinib Pathway, Pharmacokinetics. The drugs busulfan and cyclophosphamide and the compounds bosutinib monohydrate and nilotinib have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and bone marrow, and related mouse phenotypes are normal and liver/biliary system.

Disease Ontology:9 A myeloid leukemia that is characterized by over production of white blood cells.

Description from OMIM:45 608232

Related Diseases for Leukemia, Chronic Myeloid

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Diseases in the Myeloid Leukemia family:

Leukemia, Acute Myeloid leukemia, chronic myeloid
Subacute Myeloid Leukemia Acute Myeloid Leukemia, Adult
Npm1-Related Acute Myeloid Leukemia Inherited Acute Myeloid Leukemia
'acute Myeloid Leukemia with T(9;11)(p22;q23)' 'acute Myeloid Leukemia with T(6;9)(p23;q34)'

Diseases related to Leukemia, Chronic Myeloid via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 213)
idRelated DiseaseScoreTop Affiliating Genes
1chronic myelomonocytic leukemia31.0BCR, RUNX1
2myelodysplastic syndrome30.8ABL1, RUNX1
3myeloid leukemia30.8ABL1, RUNX1, BCR
4leukemia30.7BCR, ABL1, RUNX1
5acute leukemia30.4BCR, RUNX1, ABL1
6systemic lupus erythematosus30.3BCR, RUNX1
7gastrointestinal stromal tumor30.1BCR, ABL1
8chronic lymphocytic leukemia30.0ABL1, BCR
9retinoblastoma29.9BCR, RUNX1, ABL1
10hematopoietic stem cell transplantation10.7
11lymphoblastic leukemia10.7
12philadelphia-negative chronic myeloid leukemia10.7
13myelofibrosis10.5
14thrombocytosis10.5
15priapism10.5
16polycythemia10.5
17endotheliitis10.5
18polycythemia vera10.4
19hepatitis10.4
20subacute myeloid leukemia10.4
21sarcoma10.4
22essential thrombocythemia10.4
23glomerulonephritis10.4
24hepatitis b10.4
25polyneuropathy10.4
26obesity10.3
27neurofibromatosis, type 110.3
28bronchiolitis obliterans10.3
29bronchiolitis10.3
30bronchiolitis obliterans organizing pneumonia10.3
31acute basophilic leukemia10.3
32leukemia, juvenile myelomonocytic10.3RUNX1
33leukemoid reaction10.3
34colorectal cancer10.3
35wilms tumor10.3
36anaplastic large cell lymphoma10.3
37b-cell lymphomas10.3
38thrombocytopenia10.3
39membranoproliferative glomerulonephritis10.3
40splenic infarction10.3
41portal vein thrombosis10.3
42gynecomastia10.3
43hypercalcemia10.3
44pulmonary alveolar proteinosis10.3
45adenocarcinoma10.3
46calcinosis10.3
47colitis10.3
48colon adenocarcinoma10.3
49hypopyon10.3
50plasmacytoma10.3

Graphical network of the top 20 diseases related to Leukemia, Chronic Myeloid:



Diseases related to leukemia, chronic myeloid

Symptoms for Leukemia, Chronic Myeloid

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Symptoms by clinical synopsis from OMIM:

608232

Clinical features from OMIM:

608232

HPO human phenotypes related to Leukemia, Chronic Myeloid:

id Description Frequency HPO Source Accession
1 somatic mutation HP:0001428
2 ph-positive acute lymphoblastic leukemia HP:0004848
3 chronic myelogenous leukemia HP:0005506

Drugs & Therapeutics for Leukemia, Chronic Myeloid

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Drug clinical trials:

Search ClinicalTrials for Leukemia, Chronic Myeloid

Search NIH Clinical Center for Leukemia, Chronic Myeloid

Inferred drug relations via UMLS60/NDF-RT39:

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Leukemia, Chronic Myeloid cell therapies at LifeMap Discovery.

Genetic Tests for Leukemia, Chronic Myeloid

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Genetic tests related to Leukemia, Chronic Myeloid:

id Genetic test Affiliating Genes
1 Chronic Myeloid Leukemia22

Anatomical Context for Leukemia, Chronic Myeloid

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MalaCards organs/tissues related to Leukemia, Chronic Myeloid:

31
Myeloid, Bone, Bone marrow, Spleen, Testes

Animal Models for Leukemia, Chronic Myeloid or affiliated genes

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MGI Mouse Phenotypes related to Leukemia, Chronic Myeloid:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.8BCR, ABL1, RUNX1
2MP:00053708.5BCR, ABL1, RUNX1

Publications for Leukemia, Chronic Myeloid

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Articles related to Leukemia, Chronic Myeloid:

idTitleAuthorsYear
1
No asthma, no parasites is a rare type of leukemia: chronic myeloid neoplasm with eosinophilia and abnormality of platelet-derived growth factor receptor alpha. (23156891)
2012

Variations for Leukemia, Chronic Myeloid

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UniProtKB/Swiss-Prot genetic disease variations for Leukemia, Chronic Myeloid:

62
id Symbol AA change Variation ID SNP ID
1SETBP1p.Asp868AsnVAR_063807
2SETBP1p.Gly870SerVAR_063809
3SETBP1p.Ile871ThrVAR_063810
4SETBP1p.Glu858LysVAR_069849

Expression for genes affiliated with Leukemia, Chronic Myeloid

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Search GEO for disease gene expression data for Leukemia, Chronic Myeloid.

Pathways for genes affiliated with Leukemia, Chronic Myeloid

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Compounds for genes affiliated with Leukemia, Chronic Myeloid

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Sources:
49PharmGKB, 12DrugBank, 43Novoseek
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Compounds related to Leukemia, Chronic Myeloid according to GeneCards Suite gene sharing:

(show all 16)
idCompoundScoreTop Affiliating Genes
1bosutinib monohydrate499.6BCR, ABL1
2nilotinib49 1210.6ABL1, BCR
3homoharringtonine43 49 1211.6BCR, ABL1
4busulfan43 49 1211.6BCR, ABL1
5ponatinib49 1210.6ABL1, BCR
6dasatinib43 49 1211.5BCR, ABL1
7cytarabine43 49 1211.4BCR, ABL1
8ceramide439.4BCR, ABL1
9phenylalanine439.3ABL1, BCR
10phosphotyrosine439.2BCR, ABL1
11imatinib43 49 1211.1BCR, ABL1, RUNX1
12dmso439.1BCR, ABL1, RUNX1
13oligonucleotide439.0RUNX1, ABL1, BCR
14threonine439.0BCR, ABL1, RUNX1
15tyrosine438.8BCR, ABL1, RUNX1
16serine438.5BCR, ABL1, RUNX1

GO Terms for genes affiliated with Leukemia, Chronic Myeloid

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Biological processes related to Leukemia, Chronic Myeloid according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor receptor signaling pathwayGO:00480089.3BCR, ABL1
2actin cytoskeleton organizationGO:00300369.3BCR, ABL1
3regulation of cell cycleGO:00517269.2BCR, ABL1
4peptidyl-tyrosine phosphorylationGO:00181089.0BCR, ABL1

Molecular functions related to Leukemia, Chronic Myeloid according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein tyrosine kinase activityGO:00047139.2BCR, ABL1
2ATP bindingGO:00055248.5BCR, ABL1, RUNX1
3DNA bindingGO:00036778.5SETBP1, ABL1, RUNX1

Products for genes affiliated with Leukemia, Chronic Myeloid

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Sources for Leukemia, Chronic Myeloid

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet