Leukemia, Chronic Myeloid, Somatic malady
Categories: Genetic diseases, Rare diseases, Blood diseases, Cancer diseases, Immune diseases
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Aliases & Descriptions for Leukemia, Chronic Myeloid, Somatic:
Orphanet epidemiological data:53
chronic myelogenous leukemia:
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe),1-9/100000 (France),1-9/100000 (United States); Age of onset: Adult
leukemia, chronic myeloid, somatic:
Inheritance: somatic mutation
Global: Genetic diseases, Rare diseases, Cancer diseases
Anatomical: Blood diseases, Immune diseases
Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
Rare haematological diseases
MedlinePlus:37 Leukemia is cancer of the white blood cells. white blood cells help your body fight infection. your blood cells form in your bone marrow. in leukemia, the bone marrow produces abnormal white blood cells. these cells crowd out the healthy blood cells, making it hard for blood to do its work. in chronic myeloid leukemia (cml), there are too many granulocytes, a type of white blood cell. most people with cml have a gene mutation (change) called the philadelphia chromosome. sometimes cml does not cause any symptoms. if you have symptoms, they may include: fatigue weight loss night sweats fever pain or a feeling of fullness below the ribs on the left side tests that examine the blood and bone marrow diagnose cml. treatments include chemotherapy, stem cell transplants, infusion of donated white blood cells following stem cell transplants, surgery to remove the spleen, and biologic and targeted therapies. biologic therapy boosts your body's own ability to fight cancer. targeted therapy uses substances that attack cancer cells without harming normal cells. nih: national cancer institute
MalaCards based summary: Leukemia, Chronic Myeloid, Somatic, also known as chronic myelogenous leukemia, is related to atypical chronic myeloid leukemia and familial chronic myelocytic leukemia-like syndrome, and has symptoms including ph-positive acute lymphoblastic leukemia, chronic myelogenous leukemia and chest pain. An important gene associated with Leukemia, Chronic Myeloid, Somatic is BCR (BCR, RhoGEF And GTPase Activating Protein), and among its related pathways are Osteoblast Signaling and Gefitinib Pathway, Pharmacokinetics. The drugs cyclophosphamide and interferon alfa-2b have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and bone marrow, and related mouse phenotypes are craniofacial and embryo.
UniProtKB/Swiss-Prot:69 Leukemia, chronic myeloid: A clonal myeloproliferative disorder of a pluripotent stem cell with a specific cytogenetic abnormality, the Philadelphia chromosome (Ph), involving myeloid, erythroid, megakaryocytic, B-lymphoid, and sometimes T-lymphoid cells, but not marrow fibroblasts. Leukemia, chronic myeloid, atypical: A myeloproliferative disorder that shares clinical and laboratory features with chronic myeloid leukemia but lacks the pathognomonic Philadelphia chromosome and the corresponding BCR/ABL1 fusion transcript. Features include myeloid predominance in the bone marrow, myeloid proliferation and low leukocyte alkaline phosphatase value, splenomegaly, hepatomegaly, elevated white blood cell count. Enlarged spleen may also be associated with a hypermetabolic state, fever, weight loss, and chronic fatigue. The enlarged liver may contribute to the patient's weight loss.
Genetics Home Reference:25 Chronic myeloid leukemia is a slow-growing cancer of the blood-forming tissue (bone marrow). Normal bone marrow produces red blood cells (erythrocytes) that carry oxygen, white blood cells (leukocytes) that protect the body from infection, and platelets (thrombocytes) that are involved in blood clotting. In chronic myeloid leukemia, the bone marrow produces too many white blood cells. Initially, these cells function relatively normally. However, as the condition progresses, immature white blood cells called myeloblasts (or blasts) accumulate in the blood and bone marrow. The overgrowth of myeloblasts impairs development of other blood cells, leading to a shortage of red blood cells (anemia) and platelets.
Disease Ontology:11 A myeloid leukemia that is characterized by over production of white blood cells.
Description from OMIM:51 608232
UMLS symptoms related to Leukemia, Chronic Myeloid, Somatic:chest pain, hepatomegaly
FDA approved drugs:(show all 7)
Drugs for Leukemia, Chronic Myeloid, Somatic (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):(show top 50) (show all 528)
Interventional clinical trials:(show top 50) (show all 1433)
Search NIH Clinical Center for Leukemia, Chronic Myeloid, Somatic
Inferred drug relations via UMLS67/NDF-RT45:
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Leukemia, Chronic Myeloid, Somatic cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Leukemia, Chronic Myeloid, Somatic:
Embryonic/Adult Cultured Cells Related to Leukemia, Chronic Myeloid, Somatic:
MalaCards organs/tissues related to Leukemia, Chronic Myeloid, Somatic:35
Myeloid, Bone, Bone marrow, T cells, Spleen, Liver, Testes
MGI Mouse Phenotypes related to Leukemia, Chronic Myeloid, Somatic:40 (show all 21)
UniProtKB/Swiss-Prot genetic disease variations for Leukemia, Chronic Myeloid, Somatic:69
Copy number variations for Leukemia, Chronic Myeloid, Somatic from CNVD:6 (show all 45)
Search GEO for disease gene expression data for Leukemia, Chronic Myeloid, Somatic.
Pathways related to Leukemia, Chronic Myeloid, Somatic according to KEGG:33
Pathways related to Leukemia, Chronic Myeloid, Somatic according to GeneCards Suite gene sharing:(show all 46)
Cellular components related to Leukemia, Chronic Myeloid, Somatic according to GeneCards Suite gene sharing:
Biological processes related to Leukemia, Chronic Myeloid, Somatic according to GeneCards Suite gene sharing:(show all 48)
Molecular functions related to Leukemia, Chronic Myeloid, Somatic according to GeneCards Suite gene sharing:(show all 15)
30ICD10 via Orphanet
39MESH via Orphanet
52OMIM via Orphanet
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
68UMLS via Orphanet