MCID: LKM024
MIFTS: 33

Leukemia/lymphoma, T-Cell malady

Immune category

Summaries for Leukemia/lymphoma, T-Cell

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33MalaCards
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MalaCards: Leukemia/lymphoma, T-Cell is related to adult t-cell leukemia and t-cell leukemia. An important gene associated with Leukemia/lymphoma, T-Cell is TCL1B (T-cell leukemia/lymphoma 1B), and among its related pathways are Primary immunodeficiency and PI3K-Akt signaling pathway. Affiliated tissues include skin, liver and lymph node, and related mouse phenotypes are tumorigenesis and immune system.

Aliases & Classifications for Leukemia/lymphoma, T-Cell

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47OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune


Aliases & Descriptions:

leukemia/lymphoma, t-cell 47


Related Diseases for Leukemia/lymphoma, T-Cell

Sources:
17GeneCards, 18GeneDecks
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Graphical network of diseases related to Leukemia/lymphoma, T-Cell:



Diseases related to leukemia/lymphoma, t-cell

Clinical Features for Leukemia/lymphoma, T-Cell

Drugs & Therapeutics for Leukemia/lymphoma, T-Cell

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5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Leukemia/lymphoma, T-Cell

Drug clinical trials:

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Search CenterWatch for Leukemia/lymphoma, T-Cell

Genetic Tests for Leukemia/lymphoma, T-Cell

Anatomical Context for Leukemia/lymphoma, T-Cell

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33MalaCards
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MalaCards organs/tissues related to Leukemia/lymphoma, T-Cell:

33
Skin, Liver, Lymph node, Spleen, Bone marrow, Thyroid, Breast, Prostate, Testis, Tonsil, Myeloid, Monocytes, Nk cells, T cells, B lymphoblasts, B cells, Endothelial

Animal Models for Leukemia/lymphoma, T-Cell or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Leukemia/lymphoma, T-Cell:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000200610.4HES1, PRF1, BAG1, GLI1, CD19, CDKN2C
2MP:000538710.4RAG1, HES1, TNFSF8, TNFRSF18, GAS6, PIM2
3MP:000539710.4PIM2, GAS6, TNFRSF18, HES1, PRF1, BAG1
4MP:000536710.4GLI1, DLL1
5MP:001076810.3GAS6, PRF1, BAG1, GLI1, CD19, CDKN2C
6MP:000538410.3HES1, TNFRSF18, GAS6, PIM2, PRF1, GLI1
7MP:000538110.1HES1, GLI1, CD19, DLL1, IL2RG, RAG1

Publications for Leukemia/lymphoma, T-Cell

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51PubMed
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Articles related to Leukemia/lymphoma, T-Cell:

(show top 50)    (show all 302)
idTitleAuthorsYear
1
Stevens-Johnson Syndrome associated with mogamulizumab treatment of adult T-cell leukemia / lymphoma. (23360455)
2013
2
Loss of Foxp3 is associated with CD30 expression in the anaplastic large cell subtype of adult T-cell leukemia/lymphoma (ATLL) in US/Caribbean patients: potential therapeutic implications for CD30 antibody-mediated therapy. (23797717)
2013
3
First description of the t(10;11)(q22;q23)/MLL-TET1 translocation in a T-cell lymphoblastic lymphoma, with subsequent lineage switch to acute myelomonocytic myeloid leukemia. (24323992)
2013
4
Histopathological, immunophenotypic and clinical particularities and evolution of a case of hepatosplenic T-cell lymphoma in transformation to leukemia. (24399013)
2013
5
Ethacrynic acid and a derivative enhance apoptosis in arsenic trioxide-treated myeloid leukemia and lymphoma cells: the role of glutathione S-transferase p1-1. (23082001)
2012
6
Autologous and allogeneic stem-cell transplantation for transformed chronic lymphocytic leukemia (Richter's syndrome): A retrospective analysis from the chronic lymphocytic leukemia subcommittee of the chronic leukemia working party and lymphoma working party of the European Group for Blood and Marrow Transplantation. (22547610)
2012
7
Tax is a potential molecular target for immunotherapy of adult T-cell leukemia/lymphoma. (22735080)
2012
8
Cancer/testis antigens are novel targets of immunotherapy for adult T-cell leukemia/lymphoma. (22323448)
2012
9
A case of hairy cell leukemia with CCND1-IGH@ translocation: indolent non-nodal mantle cell lymphoma revisited. (21677543)
2011
10
Antibody therapy for Adult T-cell leukemia-lymphoma. (21993874)
2011
11
Aberrant overexpression of membrane-associated mucin contributes to tumor progression in adult T-cell leukemia/lymphoma cells. (21599593)
2011
12
Trends in HTLV-1 prevalence and incidence of adult T-cell leukemia/lymphoma in Nagasaki, Japan. (20166187)
2010
13
Therapeutic hotline: Primary cutaneous CD4 + small/medium-sized pleomorphic T cell lymphoma coexisting with myelodysplastic syndrome transforming into chronic myelomonocytic leukemia successfully treated with cyclophosphamide. (21054711)
2010
14
Complete remission in two cases of adult T-cell leukemia/lymphoma treated with hyper-CVAD: a case report and review of the literature. (21156467)
2010
15
Ocular manifestations and pathology of adult T-cell leukemia/lymphoma associated with human T-lymphotropic virus type 1. (21234255)
2010
16
Nelarabine for the treatment of patients with relapsed or refractory T-cell acute lymphoblastic leukemia or lymphoblastic lymphoma. (19825456)
2009
17
Phase 2 study of the efficacy and safety of the combination of arsenic trioxide, interferon alpha, and zidovudine in newly diagnosed chronic adult T-cell leukemia/lymphoma (ATL). (19411628)
2009
18
Adult T-cell leukemia/lymphoma comprising non-floral leukemic cells in Taiwan, a country non-endemic for human T-cell leukemia virus type I. (19603347)
2009
19
Adult T-cell leukemia/lymphoma with multiple integration of HTLV-1 provirus presenting as an isolated paranasal sinus tumor: a case report. (18023035)
2008
20
Potential for molecular targeted therapy for adult T-cell leukemia/lymphoma. (18300056)
2008
21
Protein arginine methyltransferase 5 suppresses the transcription of the RB family of tumor suppressors in leukemia and lymphoma cells. (18694959)
2008
22
Oncogenic NOTCH1 control of MYC and PI3K: challenges and opportunities for anti-NOTCH1 therapy in T-cell acute lymphoblastic leukemias and lymphomas. (18765521)
2008
23
Transcriptional regulation of parathyroid hormone-related protein promoter P2 by NF-kappaB in adult T-cell leukemia/lymphoma. (17554373)
2007
24
Role of nelarabine in the treatment of T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma. (18516261)
2007
25
TPL-2 MEK kinase is not targeted by mutation in diffuse large B cell lymphoma and myeloid leukemia. (17324460)
2007
26
Immunosuppressive treatment for mixed connective tissue disease may facilitate the development of adult T cell leukemia/lymphoma in a HTLVI carrier. (16595998)
2006
27
Ala228 variant of trail receptor 1 affecting the ligand binding site is associated with chronic lymphocytic leukemia, mantle cell lymphoma, prostate cancer, head and neck squamous cell carcinoma and bladder cancer. (16217763)
2006
28
Successful treatment of HTLV-1-associated acute adult T-cell leukemia lymphoma by allogeneic bone marrow transplantation: a 12 year follow-up. (16966289)
2006
29
Bilateral orbital tumor as initial presenting sign in human T-cell leukemia virus-1 associated adult T-cell leukemia/lymphoma. (16086963)
2005
30
Analysis of interleukin-27 (EBI3/p28) expression in Epstein-Barr virus- and human T-cell leukemia virus type 1-associated lymphomas: heterogeneous expression of EBI3 subunit by tumoral cells. (15793300)
2005
31
Patients with malignancy requiring urgent therapy: CASE 2. Bilateral renal swelling induced by adult T-cell leukemia/lymphoma. (16170187)
2005
32
Successful treatment of extranodal Hodgkin's lymphoma in a patient with longstanding hairy cell leukemia. (16019516)
2005
33
Influence of keratinocyte growth factor on clonal growth of epithelial tumor cells, lymphoma and leukemia cells and on sensitivity of tumor cells towards 5-fluorouracil in vitro. (15375550)
2004
34
Flow cytometry in the differential diagnosis of lymphocyte-rich thymoma from precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma. (14983942)
2004
35
Human T-lymphotropic virus type-1 related adult T-cell leukemia/lymphoma presenting as a parotid mass diagnosed by fine-needle aspiration biopsy. (15468115)
2004
36
Human T-cell lymphotropic virus type-1 associated t-cell leukemia/lymphoma masquerading as necrotizing retinal vasculitis. (12208722)
2002
37
A prospective phase II clinical trial with the use of zidovudine and interferon-alpha in the acute and lymphoma forms of adult T-cell leukemia/lymphoma. (12522449)
2002
38
Hypersensitivity to mosquito bites as the primary clinical manifestation of a juvenile type of Epstein-Barr virus-associated natural killer cell leukemia/lymphoma. (11568749)
2001
39
Prolymphocytic leukemia or prolymphocytic transformation of mantle cell lymphoma. (11710698)
2001
40
Truncated TSG101 transcripts in human leukemia and lymphoma cell lines. (10664246)
2000
41
Expression of receptor tyrosine kinase HTK (hepatoma transmembrane kinase) and HTK ligand by human leukemia-lymphoma cell lines. (10221518)
1999
42
Cytogenetic and molecular characterization of T-cell acute lymphoblastic leukemia as a second tumor after anaplastic large-cell lymphoma in a boy. (10366801)
1999
43
A chronic myelogenous leukemia-like myeloproliferative disorder accompanied by T-cell lymphoblastic lymphoma with chromosome translocation t(8;13)(p11;q12): a Japanese case. (10643154)
1999
44
Familial transmission of human T-lymphotropic virus type 1 (HTLV-1) in patients with adult T-cell leukemia/lymphoma or HTLV-1-associated myelopathy. (9509844)
1998
45
Randomized trial of r-metHu granulocyte colony-stimulating factor in an intensive treatment for T-cell leukemia and advanced-stage lymphoblastic lymphoma of childhood: a Pediatric Oncology Group pilot study. (9469336)
1998
46
Long distance polymerase chain reaction for detection of chromosome translocations in B-cell lymphoma/leukemia. (9209376)
1997
47
Clinical significance of TAL1 gene alteration in childhood T-cell acute lymphoblastic leukemia and lymphoma. (8321044)
1993
48
Hematopoietic progenitor cells from patients with adult T-cell leukemia-lymphoma are not infected with human T-cell leukemia virus type 1. (7693049)
1993
49
Structural and functional analysis of oncogenes and tumor suppressor genes in adult T-cell leukemia/lymphoma shows frequent p53 mutations. (1361372)
1992
50
Tumor genesis syndrome. Hypophosphatemia accompanying Burkitt's lymphoma cell leukemia. (3724704)
1986

Genetic Variations for Leukemia/lymphoma, T-Cell

Expression for genes affiliated with Leukemia/lymphoma, T-Cell

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Leukemia/lymphoma, T-Cell

Search GEO for disease gene expression data for Leukemia/lymphoma, T-Cell.

Pathways for genes affiliated with Leukemia/lymphoma, T-Cell

Sources:
30KEGG, 38NCBI BioSystems Database, 4Cell Signaling Technology, 52QIAGEN, 56SinoBiological, 53R&D Systems
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Compounds for genes affiliated with Leukemia/lymphoma, T-Cell

GO Terms for genes affiliated with Leukemia/lymphoma, T-Cell

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16Gene Ontology
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Biological processes related to Leukemia/lymphoma, T-Cell according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of auditory receptor cell differentiationGO:04560810.4DLL1, HES1
2positive regulation of Notch signaling pathwayGO:04574710.4DLL1, HES1
3negative regulation of apoptotic processGO:04306610.3CASP5, TNFRSF18, GAS6, PIM2, BAG1
4neuronal stem cell maintenanceGO:09715010.1DLL1, HES1

Products for genes affiliated with Leukemia/lymphoma, T-Cell

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Sources for Leukemia/lymphoma, T-Cell

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet