LAD
MCID: LKC001
MIFTS: 70

Leukocyte Adhesion Deficiency (LAD) malady

Blood diseases category

Summaries for Leukocyte Adhesion Deficiency

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Leukocyte adhesion deficiency (LAD), is a rare autosomal recessive disorder characterized by... more...

MalaCards: Leukocyte Adhesion Deficiency, also known as leukocyte-adhesion deficiency syndrome, is related to vasculitis and leukemia, and has symptoms including enlargment of jaw/large jaw, white cell disorders and red cell disorders. An important gene associated with Leukocyte Adhesion Deficiency is ITGB2 (integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)), and among its related pathways are Classical antibody-mediated complement activation and amb2 Integrin signaling. The compounds tyrosine sulfate and sele have been mentioned in the context of this disorder. Affiliated tissues include monocytes, bone marrow and bone, and related mouse phenotypes are integument and respiratory system.

Description from OMIM:46 266265,116920,612840

Aliases & Classifications for Leukocyte Adhesion Deficiency

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Sources:
8Disease Ontology, 9diseasecard, 46OMIM, 10DISEASES, 48Orphanet, 60UMLS, 44Novoseek, 39NCIt, 56SNOMED-CT, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

48
leukocyte adhesion deficiency:
Inheritance: Autosomal recessive; Age of onset: Childhood; Age of death: Before age 5
leukocyte adhesion deficiency type i:
Inheritance: Autosomal recessive; Prevalence: 1-9/1000000; Age of onset: Childhood; Age of death: Before age 5


Aliases & Descriptions:

leukocyte adhesion deficiency 8 9 46 10 48
leukocyte-adhesion deficiency syndrome 8 10 60
congenital leukocyte adherence deficiency 8 60
leukocyte adhesion deficiency syndrome 44
leukocyte adhesion deficiency type 1 60
leukocyte adhesion deficiency type i 48
lad-i 48
lad 48


External Ids:

Disease Ontology8 DOID:6612, DOID:611
NCIt39 C27874
MeSH34 D018370
SNOMED-CT56 77358003
MESH via Orphanet35 D018370, C535887
ICD10 via Orphanet26 D84.8
SNOMED-CT via Orphanet57 77358003, 234582006
UMLS via Orphanet61 C0242597, C0398738

Related Diseases for Leukocyte Adhesion Deficiency

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Leukocyte Adhesion Deficiency via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 115)
idRelated DiseaseScoreTop Affiliating Genes
1vasculitis35.1ITGAX, SELE, SELL, ITGB2, ITGAM, SELP
2leukemia34.8ITGAL, RAP1A, ITGAX, ITGB2, ITGAM, SELL
3myocardial infarction34.8CYSLTR2, ITGAM, SELP, SELL, ITGAL
4periodontitis30.6IL1B
5dermatitis30.1SELE, ITGB2
6otitis media30.1IL1B
7psoriasis30.1ITGB2, ITGAL, IL1B, SELP, SELE
8non-hodgkin lymphoma13.3SELL, ITGAX, ITGAL, ITGAM
9iga glomerulonephritis13.3SELE, ITGAL, SELL
10atopic dermatitis13.3ITGAM, SELL, SELE, SELP
11plummer's disease13.3SELL, SELE
12pulmonary sarcoidosis13.3ITGAM, SELL, ITGAL
13newborn respiratory distress syndrome13.3ITGAM, SELL, ITGB2, IL1B
14cadasil13.3ITGAL, SELP, ITGB2, SELL
15allergic asthma13.3ITGAM, ITGB2, ITGAL, SELL, SELE, CYSLTR2
16ulcerative colitis13.3ITGB2, SELL, SELE, IL1B, SELP, ITGAX
17kawasaki disease13.3SELE, SELL
18graves' disease13.3SELE, ITGB2, SELL, ITGAL
19acute leukemia13.3ITGB2, SELL, ITGAX, ITGAM
20acute lymphocytic leukemia13.3SELL, ITGAL, ITGB2, ITGAM
21adenocarcinoma13.3SELL, ITGB2
22asthma13.3ITGAM, ITGB2, ITGAL, SELL, SELE, CYSLTR2
23atherosclerosis13.3ITGAM, IL1B, SELL, SELE, SELP, ITGAL
24cutaneous t cell lymphoma13.3ITGAL, SELL, SELE
25diabetes mellitus13.3ITGB2, IL1B, SELL, SELE, SELP, ITGAM
26diabetic retinopathy13.3SELL
27hepatitis13.3SELL
28myeloma13.3IL1B, ITGAL, ITGB2, SELL, ITGAM
29obesity13.3CYSLTR2, SELL, SELE
30pre-eclampsia13.3ITGAM, ITGAX, SELL, SELE, SELP, ITGB2
31rheumatoid arthritis13.3SELP, SELE, SELL, IL1B, RAP1A, ITGAM
32skin disease13.3SELE, ITGB2, ITGAL, SELL
33systemic scleroderma13.3SELE, SELL, ITGB2
34tuberculosis13.3ITGAM, ITGB2, ITGAL, IL1B, SELL
35vascular disease13.3IL1B, SELP, SELL, ITGAM
36sickle cell disease13.3SELL, SELE, SELP
37bronchopulmonary dysplasia13.3ITGAM, SELL
38septic shock13.3ITGAM, SELL, IL1B, SELE
39sepsis13.3SELP, ITGAL, ITGB2, IL1B, ITGAM, SELL
40insulin resistance13.3SELE, SELL
41b-cell chronic lymphocytic leukemia13.3ITGAL, SELL, ITGB2
42leukocyte disease10.7
43leukocyte adhesion deficiency type 110.5
44congenital disorder of glycosylation type 2c10.4
45leukocyte adhesion deficiency, type iii10.4
46pyoderma gangrenosum10.3
47congenital disorder of glycosylation10.3
48pyoderma10.3
49chronic granulomatous disease10.2
50leucocyte adhesion defect10.2

Graphical network of the top 20 diseases related to Leukocyte Adhesion Deficiency:



Diseases related to leukocyte adhesion deficiency

Clinical Features for Leukocyte Adhesion Deficiency

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Sources:
46OMIM, 48Orphanet
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Clinical features from OMIM:

266265,116920,612840

Clinical synopsis from OMIM:

116920

Symptoms:

48 (show all 27)
  • enlargment of jaw/large jaw
  • white cell disorders
  • red cell disorders
  • downslanted palpebral fissures/anti-mongoloid slanting palpebral fissures
  • large fontanelle/delayed fontanelle closure
  • low hair line (back)
  • flat face
  • anomalies of ear and hearing
  • broad nasal root
  • dolichocephaly/scaphocephaly
  • low set ears/posteriorly rotated ears
  • autosomal recessive inheritance
  • cortical atrophy without hydrocephaly/cerebral hemiatrophy/subcortical atrophy
  • seizures/epilepsy/absences/spasms/status epilepticus
  • intellectual deficit/mental/psychomotor retardation/learning disability
  • high vaulted/narrow palate
  • hypotonia
  • macroglossia/tongue protrusion/proeminent/hypertrophic
  • umbilical hernia
  • anteverted nares/nostrils
  • short stature/dwarfism/nanism
  • microcephaly
  • immunodeficiency/increased susceptibility to infections/recurrent infections
  • epicanthic folds
  • delayed dentition/eruption of teeth/lack of eruption of teeth
  • strabismus/squint
  • hypertelorism

Drugs & Therapeutics for Leukocyte Adhesion Deficiency

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Leukocyte Adhesion Deficiency

Drug clinical trials:

Search ClinicalTrials for Leukocyte Adhesion Deficiency

Search NIH Clinical Center for Leukocyte Adhesion Deficiency

Search CenterWatch for Leukocyte Adhesion Deficiency

Genetic Tests for Leukocyte Adhesion Deficiency

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Anatomical Context for Leukocyte Adhesion Deficiency

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32MalaCards
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MalaCards organs/tissues related to Leukocyte Adhesion Deficiency:

32
Monocytes, Bone marrow, Bone, Tongue, Testes, Endothelial, Whole blood, Skin, Nk cells, Myeloid

Animal Models for Leukocyte Adhesion Deficiency or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Leukocyte Adhesion Deficiency:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.7FERMT3, ITGB2, CYSLTR2
2MP:00053889.1SLC35C1, SELE, SELP, FUT8, CYSLTR2
3MP:00053858.5SELP, SELE, RAP1A, IL1B, CYSLTR2, ITGB2
4MP:00053846.9ITGAL, SELP, SLC35C1, RAP1A, RASGRP1, SELE
5MP:00107686.9SELE, TSTA3, FERMT3, ITGB2, IL1B, RAP1A
6MP:00053766.4SELE, SLC35C1, SELP, TSTA3, RASGRP2, SLAMF6
7MP:00053976.2ITGAX, RAP1A, RASGRP2, SLC35C1, SELE, SELP
8MP:00053875.4TSTA3, CYSLTR2, IL1B, RASGRP1, RAP1A, SLC35C1

Publications for Leukocyte Adhesion Deficiency

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50PubMed
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Articles related to Leukocyte Adhesion Deficiency:

(show top 50)    (show all 232)
idTitleAuthorsYear
1
Leukocyte adhesion deficiency syndrome: report on the first case in Chile and South America. (22965369)
2012
2
Novel aspects of Kindlin-3 function in humans based on a new case of leukocyte adhesion deficiency III. (22564402)
2012
3
Clinical profile of leukocyte adhesion deficiency type I. (21719937)
2012
4
Gene therapy of canine leukocyte adhesion deficiency using lentiviral vectors with human CD11b and CD18 promoters driving canine CD18 expression. (20859258)
2011
5
Treatment of canine leukocyte adhesion deficiency by foamy virus vectors expressing CD18 from a PGK promoter. (21228879)
2011
6
A rare association between leukocyte adhesion deficiency type I and psoriasis in humans. (21461256)
2011
7
Leukocyte adhesion deficiency-III: when leukocytes cannot stop. (20234282)
2010
8
Morphologic and cytokine profile characterization of Salmonella enterica serovar typhimurium infection in calves with bovine leukocyte adhesion deficiency. (20118318)
2010
9
A novel point mutation in CD18 causing leukocyte adhesion deficiency in a Chinese patient. (20529581)
2010
10
Leukocyte adhesion deficiency type II: long-term follow-up and review of the literature. (20099014)
2010
11
The clinical spectrum of leukocyte adhesion deficiency (LAD) III due to defective CalDAG-GEF1. (18709451)
2009
12
ITGB2 mutation combined with deleted ring 21 chromosome in a child with leukocyte adhesion deficiency. (19864007)
2009
13
Detection and screening of bovine leukocyte adhesion deficiency in Pakistan using molecular methods. (19490168)
2009
14
Leukocyte trafficking in a mouse model for leukocyte adhesion deficiency II/congenital disorder of glycosylation IIc. (18541720)
2008
15
Successful treatment of canine leukocyte adhesion deficiency by foamy virus vectors. (18157138)
2008
16
Unrelated bone marrow transplantation using a reduced intensity-conditioning regimen in leukocyte adhesion deficiency. (16532019)
2006
17
Conversion of the severe to the moderate disease phenotype with donor leukocyte microchimerism in canine leukocyte adhesion deficiency. (16444276)
2006
18
Core fucosylation of N-linked glycans in leukocyte adhesion deficiency/congenital disorder of glycosylation IIc fibroblasts. (15917429)
2005
19
Bovine leukocyte adhesion deficiency (BLAD): a review. (15644595)
2004
20
Leukocyte adhesion deficiency III: a group of integrin activation defects in hematopoietic lineage cells. (15640688)
2004
21
A novel genetic leukocyte adhesion deficiency in subsecond triggering of integrin avidity by endothelial chemokines results in impaired leukocyte arrest on vascular endothelium under shear flow. (12595312)
2003
22
Insights into leukocyte adhesion deficiency type 2 from a novel mutation in the GDP-fucose transporter gene. (12406889)
2003
23
Cytokine profile of a Holstein calf with bovine leukocyte adhesion deficiency during the acute-phase inflammatory response. (12520109)
2002
24
Unrelated bone marrow transplantation for leukocyte adhesion deficiency. (12476295)
2002
25
Deficient iNOS in inflammatory bowel disease intestinal microvascular endothelial cells results in increased leukocyte adhesion. (11063913)
2000
26
Leukocyte adhesion deficiency II-from A to almost Z. (11213799)
2000
27
Leukocyte adhesion deficiency in a Norwegian boy. (10680995)
1999
28
Analysis of surface antigen expression and host defense function in leukocytes from calves heterozygous or homozygous for bovine leukocyte adhesion deficiency. (10791939)
1999
29
Leukocyte adhesion deficiency II syndrome, a generalized defect in fucose metabolism. (10356134)
1999
30
Leukocyte adhesion deficiency disorder: report of one case. (10910603)
1999
31
Intramammary infections in primiparous Holsteins: heritabilities and comparisons of bovine leukocyte adhesion deficiency carriers and noncarriers. (9891275)
1998
32
Antigen-specific immune responsiveness and lymphocyte recruitment in leukocyte adhesion deficiency type II. (9138022)
1997
33
Recognition of leukochimerism during genotyping for bovine leukocyte adhesion deficiency (BLAD) by polymerase-chain-reaction-amplified DNA extracted from blood. (8580190)
1995
34
Leukocyte adhesion deficiency (LAD) II. (7587637)
1995
35
Neutrophil adhesion in leukocyte adhesion deficiency syndrome type 2. (8675661)
1995
36
Results of allogeneic bone marrow transplantation in patients with leukocyte adhesion deficiency. (7632973)
1995
37
Detection of bovine leukocyte adhesion deficiency by nonisotopic ligase chain reaction. (7912052)
1994
38
Leukocyte adhesion deficiency: recurrent childhood skin infections. (8034795)
1994
39
Aberrant capping of membrane proteins on neutrophils from patients with leukocyte adhesion deficiency. (8123856)
1994
40
Leukocyte adhesion deficiency: its clinical and molecular analyses]. (8158839)
1994
41
Two cases of Holstein calves with bovine leukocyte adhesion deficiency (BLAD) (case report). (8149901)
1994
42
Spin-trapping and chemiluminescence studies of neutrophils from a Holstein-Friesian calf with bovine leukocyte adhesion deficiency. (8396554)
1993
43
Ventral dermatitis and vasculitis in a calf with bovine leukocyte adhesion deficiency. (8440633)
1993
44
Bovine leukocyte adhesion deficiency in Danish Holstein-Friesian cattle. I. PCR screening and allele frequency estimation. (7906090)
1993
45
Brief report: recurrent severe infections caused by a novel leukocyte adhesion deficiency. (1279426)
1992
46
Leukocyte adhesion deficiency: clinical and postmortem observations. (1348581)
1992
47
Oral manifestations associated with leukocyte adhesion deficiency: a five-year case study. (2133935)
1990
48
Point mutations impairing cell surface expression of the common beta subunit (CD18) in a patient with leukocyte adhesion molecule (Leu-CAM) deficiency. (1968911)
1990
49
Leukocyte adhesion deficiency: molecular basis and functional consequences. (3078709)
1988
50
Heterogeneity in the molecular defect leading to the leukocyte adhesion deficiency. (3056730)
1988

Genetic Variations for Leukocyte Adhesion Deficiency

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Leukocyte Adhesion Deficiency:

62 (show all 15)
id Symbol AA change Variation ID SNP ID
1ITGB2p.Asp128AsnVAR_003984rs137852615
2ITGB2p.Leu149ProVAR_003985rs137852611
3ITGB2p.Gly169ArgVAR_003986rs137852612
4ITGB2p.Pro178LeuVAR_003987rs137852614
5ITGB2p.Lys196ThrVAR_003988rs137852610
6ITGB2p.Gly284SerVAR_003989rs137852616
7ITGB2p.Asn351SerVAR_003990rs137852613
8ITGB2p.Arg586TrpVAR_003991rs5030672
9ITGB2p.Arg593CysVAR_003992rs137852609
10ITGB2p.Ser138ProVAR_013402rs137852617
11ITGB2p.Gly273ArgVAR_013403rs137852618
12ITGB2p.Asp128TyrVAR_065661rs137852615
13ITGB2p.Ala239ThrVAR_065662rs179363873
14ITGB2p.Asp300ValVAR_065663rs179363874
15ITGB2p.Gly716AlaVAR_065664rs179363872

Expression for genes affiliated with Leukocyte Adhesion Deficiency

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Leukocyte Adhesion Deficiency

Search GEO for disease gene expression data for Leukocyte Adhesion Deficiency.

Pathways for genes affiliated with Leukocyte Adhesion Deficiency

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53Reactome, 37NCBI BioSystems Database, 29KEGG, 51QIAGEN, 12EMD Millipore
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Pathways related to Leukocyte Adhesion Deficiency according to GeneCards/GeneDecks:

(show all 43)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.7RASGRP1, RASGRP2
29.7SELP, ITGB2, ITGAM
39.7ITGAL
49.6IL1B, ITGB2, ITGAM
59.6ITGAM, ITGB2, IL1B
69.6ITGAM, ITGB2, IL1B
79.6ITGAM, ITGB2, IL1B
89.5ITGAL, ITGB2
9
Immune response Lectin induced complement pathway
Hide members
9.4ITGAM, ITGB2, ITGAX
10
Hide members
9.3RASGRP1, RAP1A, RASGRP2
11
Hide members
9.3RASGRP2, RAP1A, RASGRP1
12
Hide members
9.3RASGRP1, RAP1A, RASGRP2
13
Hide members
9.3RASGRP1, RAP1A, RASGRP2
149.3RASGRP2, RAP1A, RASGRP1
159.1ITGAL, ITGB2, ITGAM
169.1ITGAM, ITGB2, ITGAX, IL1B
17
Hide members
8.9RASGRP2, RAP1A, RASGRP1, IL1B
188.8ITGAM, ITGB2, ITGAL, SELP
198.8ITGAX, ITGAL, ITGAM
20
Hide members
8.8ITGB2, ITGAL, RAP1A, RASGRP2
21
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8.8RASGRP1, RAP1A, RASGRP2, SELE, SELP
22
Hide members
8.7RAP1A, ITGAX, ITGAL
238.7RAP1A, ITGAL, ITGB2, ITGAM
248.6ITGAM, ITGB2, ITGAL, SELE, SELP
25
Hide members
8.6ITGAM, ITGB2, ITGAL, ITGAX
26
Hide members
8.6ITGAM, ITGB2, ITGAL, ITGAX
27
Hide members
8.6ITGAM, ITGB2, ITGAL, ITGAX
288.6ITGAM, ITGB2, ITGAL, ITGAX
29
Hide members
8.6ITGAX, ITGAL, ITGB2, ITGAM
30
Hide members
8.6ITGAX, ITGAL, ITGB2, ITGAM
31
Hide members
8.6ITGAX, ITGAL, ITGB2, ITGAM
328.6ITGAM, ITGB2, ITGAL, ITGAX
33
Hide members
8.6ITGAM, ITGB2, ITGAL, ITGAX
34
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8.3ITGAM, ITGB2, ITGAL, ITGAX, IL1B
35
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8.3ITGAM, ITGB2, ITGAL, ITGAX, IL1B
36
Hide members
8.2ITGAM, ITGB2, ITGAL, ITGAX, RAP1A
37
Hide members
8.2ITGAM, ITGB2, ITGAL, ITGAX, RAP1A
38
Hide members
8.2ITGAM, ITGB2, ITGAL, ITGAX, RAP1A
398.1SELP, ITGAM, ITGB2, ITGAL, ITGAX, SELE
40
Hide members
7.4ITGAM, ITGB2, ITGAL, ITGAX, RASGRP1, RAP1A
41
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7.1ITGAM, ITGB2, ITGAL, ITGAX, IL1B, RASGRP1
42
Hide members
7.1ITGAM, ITGB2, ITGAL, ITGAX, IL1B, RASGRP1
43
Hide members
6.8ITGAM, ITGB2, ITGAL, ITGAX, CYSLTR2, RASGRP1

Compounds for genes affiliated with Leukocyte Adhesion Deficiency

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Sources:
44Novoseek, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Leukocyte Adhesion Deficiency according to GeneCards/GeneDecks:

(show top 50)    (show all 96)
idCompoundScoreTop Affiliating Genes
1tyrosine sulfate4410.3SELE, SELP
2sele4410.2SELP, SELE
3polylactosamine4410.2SELP, SELE
45-oxoete4410.2ITGAM, CYSLTR2
5fucoidan4410.1SELP, SELE
6gdp fucose4410.1GMDS, SELE, FUT8
7hydroxyethyl starch4410.1ITGAM, SELE, SELP
8fc 774410.0SELP, SELE
9cycloheximide4410.0ITGAX, ITGAM
10piroxicam44 1110.8ITGAM, IL1B, ITGB2
11ptca449.8ITGB2, ITGAM, SELP
12polysulfone449.8ITGAM, SELP, IL1B, ITGB2
13dmso449.7SELE, ITGAM, ITGB2, SELP
14pentoxifylline44 1110.7ITGB2, IL1B, SELP, ITGAM
15rolipram44 59 2811.7ITGAM, RAP1A, ITGB2, SELE
16atorvastatin44 49 28 11 2413.6ITGAM, SELP, SELE
17epinephrine44 11 2411.6ITGAM, CYSLTR2, SELP, SELE
18sb 20358044 5910.6ITGAM, SELE, ITGB2, IL1B
19slea449.6SELP, ITGAL, SELE
20sulfatide449.5ITGAL, SELE, SELP
21polyacrylonitrile449.5ITGAM, ITGAL, ITGB2
22genistein44 28 59 2 11 2414.4SELP, ITGAM, ITGB2, SELE, IL1B
23theophylline44 28 11 2412.3ITGAM, ITGAL, SELP
24histamine44 28 2411.2SELP, IL1B, ITGB2, SELE, ITGAM, CYSLTR2
25rantes449.2ITGAL, IL1B, ITGAM, ITGB2
26prostacyclin449.2SELP, CYSLTR2, RAP1A, IL1B, SELE
27polysaccharide449.2ITGAM, ITGB2, SELP, TSTA3, FUT8, SELE
28cytochalasin d44 5910.1ITGAL, ITGB2, ITGAX, SELE
29slex449.1SELP, SELE, ITGAM, ITGAL, ITGB2
30phorbol-12-myristate449.0ITGAX, ITGAM, ITGB2, ITGAL
31prednisolone44 28 1111.0ITGAL, ITGAM, ITGB2
32simvastatin44 49 59 28 11 2414.0SELE, ITGAM, ITGB2, ITGAL, SELP
33ly294002449.0SELP, ITGAM, ITGB2, SELE, IL1B, RAP1A
34cuprophan448.9SELP, IL1B, ITGAL, ITGB2, ITGAM
35endotoxin448.9ITGB2, ITGAL, IL1B, ITGAM, SELE
36adenylate448.9SELP, SELE, RAP1A, ITGB2, ITGAM, CYSLTR2
37isoproterenol44 119.8RAP1A, ITGB2, ITGAM, SELE, ITGAL
38n-formylmethionyl-leucylphenylalanine448.8SELP, ITGB2, ITGAM, ITGAL, ITGAX
39heparin44 28 11 2411.8ITGB2, ITGAL, CYSLTR2, SELP, SELE, ITGAM
40vegf448.7IL1B, SELP, SELE, CYSLTR2, ITGB2, ITGAM
41aspirin44 49 28 2411.6ITGAM, IL1B, ITGAL, CYSLTR2, SELP, SELE
42phorbol448.6ITGAX, RAP1A, ITGAM, ITGB2, ITGAL
43fibrinogen448.4SELP, ITGAX, SELE, ITGAL, ITGB2, ITGAM
44superoxide44 249.2ITGAM, ITGB2, ITGAL, RAP1A, IL1B, ITGAX
45pge2448.2RAP1A, SELP, ITGAL, CYSLTR2, SELE, IL1B
46leukotriene b444 59 2410.2CYSLTR2, ITGAM, ITGB2, SELP, ITGAL, IL1B
47retinoic acid44 249.0SELP, IL1B, ITGAX, ITGAL, ITGAM, ITGB2
48fmlp447.7IL1B, CYSLTR2, ITGAL, ITGAX, ITGB2, SELP
49oxygen44 248.6RAP1A, ITGAM, ITGB2, CYSLTR2, ITGAX, ITGAL
50nitric oxide44 11 249.4RAP1A, SELE, CYSLTR2, ITGB2, SELP, ITGAL

GO Terms for genes affiliated with Leukocyte Adhesion Deficiency

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Sources:
16Gene Ontology
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Cellular components related to Leukocyte Adhesion Deficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.5SELP, ITGAX, ITGAL, ITGAM
2integrin complexGO:0083058.5ITGAM, ITGB2, ITGAL, ITGAX
3plasma membraneGO:0058865.3SELP, ITGAM, ITGB2, ITGAL, ITGAX, CD53

Biological processes related to Leukocyte Adhesion Deficiency according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1response to ATPGO:03319810.1IL1B
2de novo GDP-L-fucose biosynthetic processGO:04235110.1GMDS, TSTA3
3GDP-mannose metabolic processGO:01967310.1TSTA3, GMDS
4positive regulation of leukocyte migrationGO:00268710.0SELP, SELE
5leukocyte tethering or rollingGO:0509019.9SELE, SELP
6neutrophil chemotaxisGO:0305939.8IL1B, ITGB2, ITGAM
7activated T cell proliferationGO:0507989.4ITGAL, ITGAM
8heterophilic cell-cell adhesionGO:0071579.4SELP, SELE, ITGAL
9regulation of immune responseGO:0507769.2ITGAL, ITGB2
10platelet activationGO:0301689.1RASGRP1, RAP1A, RASGRP2, SELP
11inflammatory responseGO:0069548.8ITGB2, ITGAL, IL1B, SELE, SELP
12cell adhesionGO:0071558.6SELP, ITGAX, ITGAL, ITGB2, ITGAM
13integrin-mediated signaling pathwayGO:0072298.6ITGAM, ITGB2, ITGAL, ITGAX, FUT8
14leukocyte migrationGO:0509008.4ITGAM, ITGB2, ITGAL, ITGAX, SELE, SELP
15leukocyte cell-cell adhesionGO:0071598.3TSTA3, FERMT3, ITGAM, ITGB2, ITGAL, SELE
16signal transductionGO:0071657.8ITGAL, CD53, IL1B, RASGRP1, RAP1A, RASGRP2
17blood coagulationGO:0075967.2ITGAM, ITGB2, ITGAL, ITGAX, RASGRP1, RAP1A

Molecular functions related to Leukocyte Adhesion Deficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sialic acid bindingGO:03369110.0SELP, SELE
2glycosphingolipid bindingGO:0432089.9SELP
3oligosaccharide bindingGO:0704929.9SELP, SELE
4glycoprotein bindingGO:0019489.7SELP, ITGB2, ITGAM

Products for genes affiliated with Leukocyte Adhesion Deficiency

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Leukocyte Adhesion Deficiency

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet