MCID: LKC003
MIFTS: 46

Leukocyte Disease

Categories: Blood diseases

Aliases & Classifications for Leukocyte Disease

MalaCards integrated aliases for Leukocyte Disease:

Name: Leukocyte Disease 12 14
Leukocyte Disorders 42 69
Abnormality of Leukocytes 29

Classifications:



External Ids:

Disease Ontology 12 DOID:9500
ICD10 33 D72.9
ICD9CM 35 288 288.9
MeSH 42 D007960
UMLS 69 C0023510

Summaries for Leukocyte Disease

MalaCards based summary : Leukocyte Disease, also known as leukocyte disorders, is related to cytoplasmic body myopathy and primary bone lymphoma. An important gene associated with Leukocyte Disease is IL5 (Interleukin 5), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Mitoxantrone and Enalapril have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone and myeloid, and related phenotypes are hematopoietic system and immune system

Related Diseases for Leukocyte Disease

Diseases related to Leukocyte Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 172)
id Related Disease Score Top Affiliating Genes
1 cytoplasmic body myopathy 11.0 IL13 IL5
2 primary bone lymphoma 11.0 FIP1L1 PDGFRA
3 sideroblastic anemia 10.9 CSF2 IL3 IL5
4 myofibroma 10.9 IL13 IL5 TLR9
5 penis agenesis 10.9 CCL11 IL5
6 cholesteatoma of middle ear 10.9 CCL11 IL13 IL5
7 2p16.1-p15 deletion syndrome 10.9 CSF3 ELANE
8 exudative vitreoretinopathy 2, x-linked 10.9 CSF2 IL13 IL5
9 antley-bixler syndrome with genital anomalies and disordered steroidogenesis 10.9 CCL11 IL13 IL5
10 cherry allergy 10.9 IL13 IL4 IL5
11 fibrous histiocytoma 10.9 CCL11 IL4 IL5
12 movement disease 10.9 FIP1L1 KIT PDGFRA
13 lagophthalmos 10.9 FIP1L1 IL4 PDGFRA
14 myofascial pain syndrome 10.9 CCL11 IL13 IL5
15 marasmus 10.9 IL4 IL5 RNASE3
16 dedifferentiated liposarcoma 10.9 KIT PDGFRA
17 toxic diffuse goiter 10.9 IL13 IL5 RNASE3
18 cannabis abuse 10.9 CCL11 IL5 RNASE3
19 appendix leiomyoma 10.9 CD34 KIT
20 aortic arch interruption 10.9 IL13 IL5
21 small intestine leiomyosarcoma 10.9 CD34 KIT
22 spindle cell variant squamous cell breast carcinoma 10.9 IL13 IL4 IL5
23 anterior dislocation of lens 10.9 CCL11 IL4 RNASE3
24 alopecia antibody deficiency 10.9 FIP1L1 KIT PDGFRA
25 loiasis 10.8 IL13 IL4 IL5
26 heart septal defect 10.8 CD40LG RNASE3
27 liver inflammatory pseudotumor 10.8 CD34 KIT
28 nut allergy 10.8 IL4 IL5 RNASE3
29 somatoform disorder 10.8 CD40LG RNASE3 TLR9
30 acute vascular insufficiency of intestine 10.8 CD40LG IL4 TLR9
31 visual snow syndrome 10.8 IL2 IL4
32 ostertagiasis 10.8 CD40LG IL4 TLR9
33 temporal lobe epilepsy 10.8 FIP1L1 KIT PDGFRA
34 conjunctival concretion 10.8 CCL11 IL13 IL5
35 motor peripheral neuropathy 10.8 CD40LG IL4 TLR9
36 glucose intolerance 10.8 CSF2 IL13 IL4 IL5
37 glioblastoma multiforme 10.8 CD40LG IL5 RNASE3
38 abnormal retinal correspondence 10.8 IL2 IL4 IL5
39 whistling face syndrome, recessive form 10.8 IL2 IL5 RNASE3
40 gastric ulcer 10.8 IL2 IL5 TLR9
41 exophthalmos 10.8 ELANE IL5 RNASE3
42 subcorneal pustular dermatosis 10.8 CCL11 CD40LG IL4
43 dengue disease 10.8 IL13 IL4 IL5 TLR9
44 anus leiomyoma 10.8 CD34 KIT
45 olfactory nerve disease 10.8 IL2 IL3 KIT
46 apple allergy 10.8 CCL11 IL4 IL5 RNASE3
47 female urethral cancer 10.8 CCL11 IL4 IL5 RNASE3
48 legionellosis 10.7 IL2 IL4 TLR9
49 papillary follicular thyroid adenocarcinoma 10.7 FIP1L1 IL5 PDGFRA RNASE3
50 discoid lupus erythematosus of eyelid 10.7 IL13 IL4 IL5 TLR9

Comorbidity relations with Leukocyte Disease via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Heart Disease

Graphical network of the top 20 diseases related to Leukocyte Disease:



Diseases related to Leukocyte Disease

Symptoms & Phenotypes for Leukocyte Disease

MGI Mouse Phenotypes related to Leukocyte Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.34 CCL11 CD34 CD40LG CSF2 CSF3 CSF3R
2 immune system MP:0005387 10.31 CSF2 CSF3 CSF3R ELANE G6PC3 HAX1
3 cellular MP:0005384 10.22 CD34 CD40LG CSF2 CSF3R HAX1 IL13
4 mortality/aging MP:0010768 10.13 CD40LG CSF2 CSF3R ELANE G6PC3 HAX1
5 endocrine/exocrine gland MP:0005379 10.11 CD40LG CSF2 G6PC3 HAX1 IL13 IL2
6 integument MP:0010771 9.97 KIT PDGFRA CD34 CD40LG CSF2 CSF3
7 neoplasm MP:0002006 9.8 CD34 CSF2 ELANE IL2 IL5 KIT
8 renal/urinary system MP:0005367 9.7 CD40LG CSF2 CSF3 IL4 KIT PDGFRA
9 reproductive system MP:0005389 9.56 IL2 IL4 IL5 KIT PDGFRA CD40LG
10 respiratory system MP:0005388 9.23 PDGFRA CCL11 CSF2 IL13 IL2 IL4

Drugs & Therapeutics for Leukocyte Disease

Drugs for Leukocyte Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 917)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mitoxantrone Approved, Investigational Phase 4,Phase 2,Phase 1 65271-80-9 4212
2
Enalapril Approved, Vet_approved Phase 4 75847-73-3 5362032 40466924
3
Enalaprilat Approved Phase 4 76420-72-9 6917719
4
Sertraline Approved Phase 4 79617-96-2 68617
5
Dopamine Approved Phase 4,Phase 3,Phase 2 51-61-6, 62-31-7 681
6
Sulpiride Approved Phase 4 15676-16-1 5355
7
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 2 185243-69-0
8
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1 1959-05-2, 59-05-2 126941
9
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 83-43-2 6741
10
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-24-8 5755
11
Micafungin Approved, Investigational Phase 4,Phase 3,Phase 2 235114-32-6 3081921 477468
12
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 22916-47-8 4189
13
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 53-03-2 5865
14
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-78-2 2244
15
Thrombin Approved Phase 4
16
Desogestrel Approved Phase 4 54024-22-5 40973
17
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
18
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
19
Etonogestrel Approved, Investigational Phase 4 54048-10-1 40976 6917715
20
Artemether Approved Phase 4 71963-77-4 119380 68911
21
Lumefantrine Approved Phase 4 82186-77-4 6437380
22
Midazolam Approved, Illicit Phase 4,Phase 2 59467-70-8 4192
23
Morphine Approved, Investigational Phase 4 57-27-2 5288826
24
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
25
Ceftazidime Approved Phase 4 78439-06-2, 72558-82-8 5481173
26
Meropenem Approved, Investigational Phase 4 119478-56-7 64778 441130
27
Piperacillin Approved Phase 4,Phase 3 66258-76-2 43672
28
Tazobactam Approved Phase 4,Phase 3 89786-04-9 123630
29
Vancomycin Approved Phase 4,Phase 3 1404-90-6 441141 14969
30
Cyclophosphamide Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 50-18-0, 6055-19-2 2907
31
Lenograstim Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 135968-09-1
32 Thiotepa Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 52-24-4 5453
33
Efavirenz Approved, Investigational Phase 4,Phase 1 154598-52-4 64139
34
Lamivudine Approved, Investigational Phase 4,Phase 2,Phase 1 134678-17-4 60825
35
Zinc Approved Phase 4,Phase 3,Phase 1,Phase 2 7440-66-6 32051 23994
36
Metformin Approved Phase 4,Phase 2,Phase 3,Phase 1 657-24-9 14219 4091
37
Menthol Approved Phase 4,Phase 2,Phase 1 2216-51-5 16666
38
Bevacizumab Approved, Investigational Phase 4,Phase 2 216974-75-3
39
Budesonide Approved Phase 4,Phase 3,Phase 2 51333-22-3 63006 5281004
40
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-02-2 5743
41
Benzocaine Approved Phase 4,Phase 3,Phase 2,Phase 1 1994-09-7, 94-09-7 2337
42
Metoprolol Approved, Investigational Phase 4,Phase 2 37350-58-6, 51384-51-1 4171
43
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 128794-94-5 5281078
44
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 24280-93-1 446541
45
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 104987-11-3 445643 439492
46
Dexlansoprazole Approved Phase 4,Phase 3,Phase 2,Phase 1 138530-94-6, 103577-45-3 9578005
47
Lansoprazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 103577-45-3 3883
48
Rabeprazole Approved, Investigational Phase 4 117976-89-3 5029
49
Saxagliptin Approved Phase 4,Phase 2 361442-04-8 11243969
50
Linezolid Approved, Investigational Phase 4,Phase 3 165800-03-3 441401

Interventional clinical trials:

(show top 50) (show all 2146)

id Name Status NCT ID Phase Drugs
1 Efficacy and Safety of Mitoxantrone in Patients With Refractory Neuromyelitis Optica and Spectrum Disorders Unknown status NCT02021825 Phase 4 Mitoxantrone
2 Randomized, Double-blind, Placebo-controlled Study to Evaluate the Effect of Roflumilast on Endothelial Function in Patients With Chronic Obstructive Pulmonary Disease Unknown status NCT01595750 Phase 4 Roflumilast 500;Placebo
3 Anti-Hypertensive Agent (ACEi) and Heart Function Improvement in Association With Rho Kinase Activity Changes in Human Unknown status NCT01069042 Phase 4 Enalapril
4 Preliminary Study to Investigate the Effect of rTMS and SSRI Antidepressants on Leukocyte Expression of the C-FOS and DUSP1 Genes in Patients Treated for Depression Unknown status NCT02042573 Phase 4 SSRI (SEROPLEX ou ZOLOFT)
5 Association of Amisulpride Response in Schizophrenia With Brain Image Unknown status NCT02095938 Phase 4 amisulpride
6 Remission Induction in Very Early Rheumatoid Arthritis Unknown status NCT00523692 Phase 4 Etanercept, methotrexate and depomedrone;depemedrone
7 Micafungin Prevention Study for Fungal Disease in Child Receiving Allogenic Hematopoietic Stem Cell Transplantation Unknown status NCT01135589 Phase 4 Micafungin
8 Rosuvastatin Effect on Telomere-telomerase System in ACS Unknown status NCT02299245 Phase 4 rosuvastatin
9 Steroids Pharmacokinetics and the Response to Prednisone Therapy in Giant Cell Arteritis Unknown status NCT01400464 Phase 4 Prednisone therapy and pharmacokinetic
10 Atorvastatin, Aspirin, Oxidative Stress, Coagulation and Platelet Activation Indexes Unknown status NCT01322711 Phase 4 Atorvastatin;Placebo
11 Effect of the Etonogestrel 0.12mg/Ethinyl Estradiol 0.015mg Vaginal Ring on Vaginal Innate and Inflammatory Biomarkers Unknown status NCT01448291 Phase 4 Etonogestrel /Ethinyl Estradiol Contraceptive Vaginal Ring
12 Improving Anti-malarial Treatment Options in Guinea-Bissau - Part A Unknown status NCT01704508 Phase 4 Artemether-lumefantrine;Dihydroartemisinin-piperaquine
13 Effect of Midazolam on Inflammatory Response and Organ Function in Mechanically Ventilated Sepsis Patients With Different Immune Status Unknown status NCT02135055 Phase 4 Midazolam;Morphine
14 Assessment Of Gh-Igf-1 Axis In Children With Chronic Myelogenous Leukemia (CML) In Remission Unknown status NCT01901666 Phase 4 Growth Hormone
15 Effects of Raltegravir Based Regimen on Platelet Reactivity, Platelet-monocyte Aggregation and Immune Activation Unknown status NCT02383355 Phase 4 Raltegravir;Continuation of own regimen
16 Effects of Sevoflurane in Subanesthetic Concentrations on the Forearm Perfusion Unknown status NCT00526695 Phase 4 Sevoflurane (Preconditioning)
17 Short vs Prolonged Antibiotic Treatment for Hospitalized Hemato-oncology Patients With Febrile Neutropenia Unknown status NCT02463747 Phase 4 Piperacillin/tazobactam;Ceftazidim;Meropenem;Vancomycin
18 A Study of Risk Factors for Anti-erythropoietin Antibody Positive Pure Red Cell Aplasia Among Patients With Chronic Kidney Disease Receiving Epoetin Alfa Completed NCT00211068 Phase 4 No intervention
19 Angioplasty in Peripheral Arterial Disease and Endothelial Function Completed NCT00660634 Phase 4
20 CYP2C19 Genetic Polymorphism on the Accuracy of Proton-Pump Inhibitor Testing Completed NCT00354757 Phase 4 rabeprazole
21 Assessment of Translesional Markers and Metabolomics Completed NCT00321139 Phase 4
22 Study to Monitor the Incidence of Pure Red Cell Aplasia (PRCA) and/or Antibodies to Erythropoietin Among Participants Receiving Epoetin Alfa or Another Erythropoietin Completed NCT00210951 Phase 4
23 Saxagliptin and Atherosclerosis Completed NCT01552018 Phase 4 Saxagliptin;Placebo
24 Safety, Immunogenicity And Efficacy Of Vaccination In Military Personnel Completed NCT01807780 Phase 4
25 Time To Efficacy and Onset Of Action Of Linezolid Completed NCT00147511 Phase 4 linezolid
26 A Study of Aripiprazole (Abilify) in Patients With Bipolar Mania Completed NCT00261443 Phase 4 Lithium or Valproate with placebo (PBO);Lithium or Valproate with Aripiprazole
27 Immune Modulation by Parenteral Fish Oil in Patients With Crohn's Disease Completed NCT02349594 Phase 4 Omegaven 10%;Intralipid 20%
28 Cystagon to Treat Infantile Neuronal Ceroid Lipofuscinosis Completed NCT00028262 Phase 4 Cystagon
29 Understanding the Immune Response to Two Different Meningitis Vaccines Completed NCT01593514 Phase 4
30 Antiviral Treatment of Chronic Lymphocytic Leukemia Completed NCT01255644 Phase 4 Valganciclovir
31 Bone Marrow Transplantation in Treating Patients With Hematologic Cancer Completed NCT00003398 Phase 4 cyclophosphamide;thiotepa
32 Varenicline Effects In Schizophrenic Smokers Completed NCT00548470 Phase 4 Varenicline
33 Leukocyte Depletion of Autologous Whole Blood Completed NCT00176124 Phase 4
34 Ticagrelor China Pharmacokinetic/Pharmacodynamic Study Completed NCT02064985 Phase 4 Inhibition of Platelet Aggregation by "Brilinta"(Ticagrelor)
35 Bacille Calmette Guérin Immunisation at Birth and Childhood Morbidity in Danish Children. Completed NCT01694108 Phase 4
36 Study to Reduce Duration of Antibiotic Therapy in Haematological Patients With Fever and Neutropenia Completed NCT01581333 Phase 4
37 A Phase IV Study of Recombinant Human Gamma Interferon in Patients With Chronic Granulomatous Diseases of Childhood Completed NCT00001317 Phase 4 interferon-gamma
38 Effect of Icodextrin on the Treatment Outcome of Peritoneal Dialysis Patients During Acute Peritonitis Completed NCT01044446 Phase 4 Icodextrin;glucose-based peritoneal dialysate
39 Phase IV:Safety and Efficacy of EMSAM in Adolescents With Major Depression Completed NCT00531947 Phase 4 Selegiline Transdermal System;Placebo
40 Fish Oils and Adipose Inflammation Reduction Completed NCT02010359 Phase 4 Lovaza;Placebo
41 Evaluation of a New Thermostable Formulation of FLOLAN in Japanese Subjects Completed NCT02705807 Phase 4 FLOLAN injection with currently marketed diluent;FLOLAN injection with reformulated diluent
42 Randomised Controlled Trial of Mechanistic Effects of Rifaximin in Cirrhosis and Chronic Hepatic Encephalopathy Completed NCT02019784 Phase 4 Rifaximin-α;Placebo Oral Tablet
43 Effect of Rowachol on Prevention of Postcholecystectomy Syndrome Completed NCT01765465 Phase 4 Rowachol;Placebo
44 A Study of the Neurobiology of Depression Completed NCT01051466 Phase 4 Duloxetine
45 Japan Assessment of Pitavastatin and Atorvastatin in Acute Coronary Syndrome (JAPAN-ACS) Completed NCT00242944 Phase 4 Pitavastatin;Atorvastatin
46 A Study Comparing the Efficacy and Safety of Duloxetine and Placebo for the Treatment of Depression in Elderly Patients Completed NCT00406848 Phase 4 duloxetine hydrochloride;placebo
47 Valganciclovir to Reduce T Cell Activation in HIV Infection Completed NCT00264290 Phase 4 Valganciclovir;Placebo
48 Dornase Alfa Therapy for Ventilator Associated Lung Infections in the Neonatal Intensive Care Unit (NICU) Completed NCT01356147 Phase 4 Dornase alfa;Placebo
49 Efficacy Study of Different Laboratory Management Strategies and Drug Regimens in HIV-infected Children in Africa Completed NCT02028676 Phase 4 Arm A: ABC+3TC+NNRTI;Arm B: ZDV+ABC+3TC+NNRTI->ABC+3TC+NNRTI maintenance;Arm C: ZDV+ABC+3TC+NNRTI->ZDV+ABC+3TC maintenance;Once-daily ABC+3TC;Twice-daily ABC+3TC;Continued cotrimoxazole prophylaxis
50 Plaque REgression With Cholesterol Absorption Inhibitor or Synthesis Inhibitor Evaluated by IntraVascular UltraSound Completed NCT01043380 Phase 4 Combination therapy with Lipitor [Atorvastatin] and Zetia [Ezetimibe];Lipitor (Atorvastatin) monotherapy

Search NIH Clinical Center for Leukocyte Disease

Cochrane evidence based reviews: leukocyte disorders

Genetic Tests for Leukocyte Disease

Genetic tests related to Leukocyte Disease:

id Genetic test Affiliating Genes
1 Abnormality of Leukocytes 29

Anatomical Context for Leukocyte Disease

MalaCards organs/tissues related to Leukocyte Disease:

39
T Cells, Bone, Myeloid, Bone Marrow, Breast, Kidney, Lung

Publications for Leukocyte Disease

Variations for Leukocyte Disease

Expression for Leukocyte Disease

Search GEO for disease gene expression data for Leukocyte Disease.

Pathways for Leukocyte Disease

Pathways related to Leukocyte Disease according to GeneCards Suite gene sharing:

(show all 40)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.03 CCL11 CD34 CD40LG CSF2 CSF3 CSF3R
2
Show member pathways
13.89 CCL11 CD40LG CSF2 CSF3 CSF3R IL13
3
Show member pathways
13.7 CCL11 CD40LG CSF2 CSF3 CSF3R IL13
4
Show member pathways
13.52 CCL11 IL13 IL2 IL3 IL4 IL5
5
Show member pathways
13.38 CCL11 CD40LG CSF2 CSF3 CSF3R IL13
6
Show member pathways
13.33 CCL11 CD40LG CSF2 CSF3 CSF3R IL13
7
Show member pathways
13.28 CCL11 CD40LG CSF2 CSF3 CSF3R IL13
8
Show member pathways
12.9 CCL11 CD40LG IL13 IL2 IL3 IL4
9 12.74 CSF3 CSF3R G6PC3 IL2 IL3 IL4
10 12.6 CD34 CD40LG IL2 IL3 IL4 KIT
11
Show member pathways
12.59 CSF2 IL13 IL3 IL4 IL5
12
Show member pathways
12.46 CD40LG CSF2 IL2 IL4 IL5
13
Show member pathways
12.41 CCL11 CSF2 CSF3 IL13 IL4 IL5
14
Show member pathways
12.4 IL13 IL2 IL5 PDGFRA
15
Show member pathways
12.22 IL13 IL2 IL3 IL4 IL5
16
Show member pathways
12.16 CSF2 CSF3 CSF3R IL13 IL2 IL3
17
Show member pathways
12.14 CSF2 IL2 IL3 IL5
18
Show member pathways
12.05 IL13 IL2 IL5 TLR9
19 11.89 CSF2 IL13 IL2 IL4 IL5
20 11.86 CD34 IL13 IL2 IL4 IL5 KIT
21 11.83 CD34 CSF2 IL2 KIT TLR9
22
Show member pathways
11.81 CD40LG CSF2 IL2 IL3 IL4 IL5
23 11.78 CD40LG IL4 IL5 TLR9
24 11.74 CD34 ELANE KIT
25 11.74 CD34 CSF2 CSF3 CSF3R IL3 IL4
26 11.73 CCL11 CD40LG IL4 IL5
27 11.68 CCL11 CSF2 CSF3 IL13 IL4 IL5
28
Show member pathways
11.65 CD40LG CSF2 IL2
29 11.61 CSF2 CSF3 IL13 IL4
30 11.6 CSF2 CSF3 IL3 IL5
31 11.59 CCL11 IL13 IL2 IL4 IL5
32 11.57 CD34 CD40LG KIT
33 11.53 CD40LG CSF3 TLR9
34 11.41 CD40LG IL2 IL4 IL5
35 11.34 CD34 CSF2 CSF3 CSF3R IL2 IL3
36 11.33 IL13 IL4 IL5
37 11.28 IL13 IL2 IL4 IL5
38 11.14 CCL11 CD40LG CSF2 CSF3 IL13 IL2
39 10.98 IL13 IL4 IL5
40 10.98 CSF2 CSF3 IL13 IL2 IL3 IL4

GO Terms for Leukocyte Disease

Cellular components related to Leukocyte Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 CCL11 CD34 CD40LG CSF2 CSF3 CSF3R
2 external side of plasma membrane GO:0009897 9.63 CD34 CD40LG IL13 IL4 KIT PDGFRA
3 extracellular space GO:0005615 9.44 CCL11 CD40LG CSF2 CSF3 ELANE IL13

Biological processes related to Leukocyte Disease according to GeneCards Suite gene sharing:

(show all 30)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.92 CSF2 CSF3 IL2 IL3 IL4 IL5
2 MAPK cascade GO:0000165 9.91 CSF2 IL2 IL3 IL5 KIT PDGFRA
3 peptidyl-tyrosine phosphorylation GO:0018108 9.88 CSF2 IL3 IL5 KIT PDGFRA
4 response to ethanol GO:0045471 9.85 CSF3 IL13 IL2 IL4
5 cytokine-mediated signaling pathway GO:0019221 9.85 CSF3 CSF3R IL3 IL5 KIT
6 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.8 CSF3 HAX1 KIT PDGFRA
7 positive regulation of T cell proliferation GO:0042102 9.79 CD40LG IL2 IL4
8 negative regulation of neuron death GO:1901215 9.78 CD34 CSF3 IL13
9 positive regulation of DNA replication GO:0045740 9.77 CSF2 IL3 PDGFRA
10 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.77 CSF3 HAX1 IL3 IL4 IL5
11 cellular response to cytokine stimulus GO:0071345 9.71 CSF3 HAX1 IL13
12 positive regulation of immunoglobulin secretion GO:0051024 9.64 IL2 IL5
13 dendritic cell differentiation GO:0097028 9.64 CSF2 IL4
14 positive regulation of podosome assembly GO:0071803 9.63 CSF2 IL5
15 positive regulation of mast cell degranulation GO:0043306 9.63 IL13 IL4
16 positive regulation of isotype switching to IgG isotypes GO:0048304 9.62 IL2 IL4
17 positive regulation of phospholipase C activity GO:0010863 9.62 KIT PDGFRA
18 immune response GO:0006955 9.61 CCL11 CD40LG CSF2 CSF3 IL13 IL2
19 mast cell chemotaxis GO:0002551 9.6 CCL11 KIT
20 negative regulation of T-helper 17 cell differentiation GO:2000320 9.58 IL2 IL4
21 regulation of proton transport GO:0010155 9.58 IL13 IL4
22 negative regulation of complement-dependent cytotoxicity GO:1903660 9.56 IL13 IL4
23 positive regulation of interleukin-10 production GO:0032733 9.56 CD34 CD40LG IL4 TLR9
24 positive regulation of B cell proliferation GO:0030890 9.46 IL13 IL2 IL4 IL5
25 positive regulation of immunoglobulin production GO:0002639 9.4 IL13 IL4
26 regulation of myeloid cell differentiation GO:0045637 9.35 CSF3R
27 neutrophil differentiation GO:0030223 9.27 CSF2
28 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.02 CSF2 IL2 IL3 IL4 KIT
29 positive regulation of GTPase activity GO:0043547 10.05 CCL11 CSF2 IL2 IL3 IL5 KIT
30 inflammatory response GO:0006954 10 CCL11 CD40LG IL13 IL5 KIT TLR9

Molecular functions related to Leukocyte Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.65 CSF2 IL3 IL5 KIT PDGFRA
2 growth factor activity GO:0008083 9.63 CSF2 CSF3 IL2 IL3 IL4 IL5
3 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.43 CSF2 IL2 IL3 IL5 KIT PDGFRA
4 cytokine activity GO:0005125 9.28 CCL11 CD40LG CSF2 CSF3 IL13 IL2

Sources for Leukocyte Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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