Leukocyte Disease

Categories: Blood diseases

Aliases & Classifications for Leukocyte Disease

MalaCards integrated aliases for Leukocyte Disease:

Name: Leukocyte Disease 12 14
Leukocyte Disorders 41 69
Abnormality of Leukocytes 28


External Ids:

Disease Ontology 12 DOID:9500
ICD10 32 D72.9
ICD9CM 34 288 288.9
MeSH 41 D007960
UMLS 69 C0023510

Summaries for Leukocyte Disease

MalaCards based summary : Leukocyte Disease, also known as leukocyte disorders, is related to neutrophilia, hereditary and pdgfra-associated chronic eosinophilic leukemia. An important gene associated with Leukocyte Disease is IL5 (Interleukin 5), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Dexamethasone and Etoposide have been mentioned in the context of this disorder. Related phenotypes are hematopoietic system and immune system

Related Diseases for Leukocyte Disease

Diseases related to Leukocyte Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 175)
# Related Disease Score Top Affiliating Genes
1 neutrophilia, hereditary 31.5 CSF2 CSF3R
2 pdgfra-associated chronic eosinophilic leukemia 10.7 FIP1L1 PDGFRA
3 cytokine deficiency 10.7 IL13 IL5
4 primary hypereosinophilic syndrome 10.7 FIP1L1 PDGFRA
5 seborrheic infantile dermatitis 10.6 CSF2 IL3 IL5
6 nut allergy 10.6 IL13 IL5 TLR9
7 strongyloidiasis 10.6 CCL11 IL13 IL5
8 pemphigoid gestationis 10.6 CCL11 IL5
9 night blindness, congenital stationary, type 1a 10.6 CSF2 IL13 IL5
10 sm-ahnmd 10.6 FIP1L1 KIT PDGFRA
11 maxillary sinus adenoid cystic carcinoma 10.6 IL2 KIT
12 apple allergy 10.6 IL13 IL4 IL5
13 radiculopathy 10.6 CCL11 IL13 IL5
14 folliculitis 10.6 CCL11 IL4 IL5
15 endomyocardial fibrosis 10.6 FIP1L1 IL4 PDGFRA
16 reticular perineurioma 10.6 KIT PDGFRA
17 paragonimiasis 10.6 IL13 IL5 RNASE3
18 chronic eosinophilic pneumonia 10.6 CCL11 IL5 RNASE3
19 gallbladder leiomyoma 10.6 CD34 KIT
20 lung leiomyosarcoma 10.6 CD34 KIT
21 angioimmunoblastic lymphadenopathy with dysproteinemia 10.6 IL13 IL5
22 cough variant asthma 10.6 IL4 IL5 RNASE3
23 chronic eosinophilic leukemia 10.6 FIP1L1 KIT PDGFRA
24 enterobiasis 10.6 IL13 IL4 IL5
25 blepharoconjunctivitis 10.6 CCL11 IL4 RNASE3
26 paranasal sinus disease 10.6 IL13 IL4 IL5
27 chronic interstitial cystitis 10.6 CD40LG RNASE3
28 liver leiomyoma 10.6 CD34 KIT
29 milk allergy 10.6 IL4 IL5 RNASE3
30 vasomotor rhinitis 10.6 CD40LG RNASE3 TLR9
31 lichen disease 10.6 CD40LG IL4 TLR9
32 systemic mastocytosis 10.5 FIP1L1 KIT PDGFRA
33 virus associated hemophagocytic syndrome 10.5 IL2 IL4
34 esophagitis 10.5 CCL11 IL13 IL5
35 zygomycosis 10.5 CSF3 ELANE
36 extrinsic cardiomyopathy 10.5 CD40LG IL4 TLR9
37 opportunistic mycosis 10.5 CD40LG IL4 TLR9
38 churg-strauss syndrome 10.5 CD40LG IL5 RNASE3
39 chronic tic disorder 10.5 CSF2 IL13 IL4 IL5
40 wells syndrome 10.5 IL2 IL5 RNASE3
41 paracoccidioidomycosis 10.5 IL2 IL4 IL5
42 status asthmaticus 10.5 ELANE IL5 RNASE3
43 cutaneous leishmaniasis 10.5 IL13 IL4 IL5 TLR9
44 filariasis 10.5 IL2 IL5 TLR9
45 deep leiomyoma 10.5 CD34 KIT
46 dermatitis herpetiformis 10.5 CCL11 CD40LG IL4
47 loeffler endocarditis 10.5 FIP1L1 IL5 PDGFRA RNASE3
48 mast cell neoplasm 10.5 IL2 IL3 KIT
49 mast cell disease 10.5 IL13 IL5 KIT PDGFRA
50 tonsillitis 10.5 IL2 IL4 TLR9

Comorbidity relations with Leukocyte Disease via Phenotypic Disease Network (PDN):

Acute Cystitis Deficiency Anemia
Heart Disease

Graphical network of the top 20 diseases related to Leukocyte Disease:

Diseases related to Leukocyte Disease

Symptoms & Phenotypes for Leukocyte Disease

MGI Mouse Phenotypes related to Leukocyte Disease:

43 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.36 G6PC3 CSF2 HAX1 IL13 CCL11 CSF3
2 immune system MP:0005387 10.31 G6PC3 CSF2 HAX1 IL13 CCL11 CSF3
3 cellular MP:0005384 10.24 CD40LG HAX1 CSF2 CD34 CSF3R IL13
4 homeostasis/metabolism MP:0005376 10.21 ELANE CD40LG G6PC3 CSF2 CD34 PDGFRA
5 endocrine/exocrine gland MP:0005379 10.18 G6PC3 CSF2 HAX1 CSF3R CD40LG IL13
6 mortality/aging MP:0010768 10.13 CD40LG ELANE G6PC3 CSF2 HAX1 CSF3R
7 integument MP:0010771 9.97 CD40LG CSF2 CSF3 CD34 IL4 IL13
8 neoplasm MP:0002006 9.8 ELANE CSF2 CD34 IL5 KIT IL2
9 renal/urinary system MP:0005367 9.7 CD40LG CSF2 CSF3 KIT PDGFRA IL4
10 reproductive system MP:0005389 9.61 CD40LG CSF2 CSF3R IL5 IL13 KIT
11 respiratory system MP:0005388 9.23 CSF2 CCL11 IL5 IL13 KIT IL2

Drugs & Therapeutics for Leukocyte Disease

Drugs for Leukocyte Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 443)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-02-2 5743
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 33419-42-0 36462
Cisplatin Approved Phase 4,Phase 3,Phase 2 15663-27-1 2767 441203 84093
Cytarabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 147-94-4 6253
Methotrexate Approved Phase 4,Phase 3,Phase 2,Not Applicable 1959-05-2, 59-05-2 126941
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-18-0, 6055-19-2 2907
Ciprofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 85721-33-1 2764
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
Budesonide Approved Phase 4,Phase 3,Phase 2,Not Applicable 51333-22-3 5281004 63006
Vancomycin Approved Phase 4,Phase 3,Phase 2,Not Applicable 1404-90-6 14969 441141
Lenograstim Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 135968-09-1
Triamcinolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 124-94-7 31307
Micafungin Approved, Investigational Phase 4,Phase 2,Phase 1 235114-32-6 477468 3081921
Cilastatin Approved, Investigational Phase 4,Not Applicable 82009-34-5 6435415 5280454
Meropenem Approved, Investigational Phase 4,Phase 2 119478-56-7 441130 64778
Imipenem Approved Phase 4,Not Applicable 64221-86-9, 74431-23-5 104838
Tazobactam Approved Phase 4,Phase 2,Not Applicable 89786-04-9 123630
Ceftazidime Approved Phase 4,Phase 3,Phase 2 72558-82-8, 78439-06-2 5481173
Piperacillin Approved Phase 4,Phase 2,Not Applicable 66258-76-2 43672
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 53-03-2 5865
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 23214-92-8 31703
Vincristine Approved, Investigational Phase 4,Phase 2 2068-78-2, 57-22-7 5978
Gemcitabine Approved Phase 4,Phase 2 95058-81-4 60750
Penicillin G Approved, Vet_approved Phase 4 61-33-6 5904
Amphotericin B Approved, Investigational Phase 4,Phase 3,Phase 2 1397-89-3 5280965 14956
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-24-8 5755
Oxaliplatin Approved, Investigational Phase 4,Phase 3,Phase 1 61825-94-3 43805 6857599 5310940 9887054
Tobramycin Approved, Investigational Phase 4,Phase 3 32986-56-4 36294 5496
Sulfamethoxazole Approved Phase 4,Phase 2 723-46-6 5329
Itraconazole Approved, Investigational Phase 4,Phase 3,Phase 2 84625-61-6 55283
Lansoprazole Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 103577-45-3 3883
Posaconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 171228-49-2 147912
Trimethoprim Approved, Vet_approved Phase 4,Phase 2 738-70-5 5578
Omalizumab Approved, Investigational Phase 4,Phase 2,Phase 1 242138-07-4
Menthol Approved Phase 4 2216-51-5 16666
Teicoplanin Approved, Investigational Phase 4 61036-62-2
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 83-43-2 6741
Dexlansoprazole Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 138530-94-6, 103577-45-3 9578005
Epirubicin Approved Phase 4,Phase 3,Phase 2,Phase 1 56420-45-2 41867
Abatacept Approved Phase 4,Phase 1 332348-12-6 10237
Ribavirin Approved Phase 4 36791-04-5 37542
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58-05-9 143 6006
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 59-30-3 6037
Niacin Approved, Investigational, Nutraceutical Phase 4,Phase 1 59-67-6 938
Nicotinamide Approved, Investigational, Nutraceutical Phase 4,Phase 1 98-92-0 936
Docetaxel Approved May 1996, Investigational Phase 4,Phase 3,Phase 2,Phase 1 114977-28-5 148124 9877265
Doxil Approved June 1999 Phase 4,Phase 3,Phase 2,Phase 1 31703
48 triamcinolone acetonide Phase 4,Phase 2,Phase 3,Phase 1
49 penicillins Phase 4,Not Applicable
50 Dexamethasone acetate Phase 4,Phase 3,Phase 2,Phase 1 1177-87-3

Interventional clinical trials:

(show top 50) (show all 643)

# Name Status NCT ID Phase Drugs
1 Prevention of Neutropenia After Using G-CSF With TAC Chemotherapy Unknown status NCT01571518 Phase 4 late leukostim;early leukostim
2 Micafungin Prevention Study for Fungal Disease in Child Receiving Allogenic Hematopoietic Stem Cell Transplantation Unknown status NCT01135589 Phase 4 Micafungin
3 Short vs Prolonged Antibiotic Treatment for Hospitalized Hemato-oncology Patients With Febrile Neutropenia Unknown status NCT02463747 Phase 4 Piperacillin/tazobactam;Ceftazidim;Meropenem;Vancomycin
4 Short Versus Extended Antibiotic Treatment With a Carbapenem for High-risk Febrile Neutropenia in Hematology Patients With FUO Unknown status NCT02149329 Phase 4 Discontinuation of imipenem-cilastatin or meropenem
5 Oral Cromolyn Sodium for the Treatment of Eosinophilic Esophagitis Unknown status NCT02371941 Phase 4 oral cromolyn sodium;Placebo
6 Dietetic Versus Topical Steroids for Pediatric Eosinophilic Esophagitis Unknown status NCT01846962 Phase 4 Budesonide;Fluticasone
7 Filgrastim or Pegfilgrastim in Preventing Neutropenia in Women Receiving Chemotherapy Following Surgery for Breast Cancer Unknown status NCT00030758 Phase 4
8 A Clinical Trial of Patients With Solid Tumours Receiving Granulocyte Colony Stimulating Factor as Primary Prophylaxis for Chemotherapy-induced Neutropenia, in a Docetaxel Based Regimen Completed NCT01107756 Phase 4 LENOGRASTIM (GRANOGYTE 34)
9 The Tobramycin Study Completed NCT00257790 Phase 4 Tobramycin once a day
10 FIRST - Study of Pegfilgrastim Administered in the First and Subsequent Cycles of Myelosuppressive Chemotherapy Completed NCT00125723 Phase 4
11 Comparison of the Pharmacodynamics of Imipenem in Patients With Febrile Neutropenia Completed NCT02213783 Phase 4 Imipenem;Imipenem
12 Study to Reduce Duration of Antibiotic Therapy in Haematological Patients With Fever and Neutropenia Completed NCT01581333 Phase 4 Empirical antimicrobial treatment discontinuation;Standard empirical antimicrobial treatment discontinuation
13 Pharmacokinetic/Pharmacodynamic Study of Doripenem in Febrile Neutropenic Patients Completed NCT01401010 Phase 4 Doripenem;doripenem
14 Comparison of Teicoplanin and Vancomycin in Initial Empirical Antibiotic Regimen for Febrile Neutropenic Patients Completed NCT00454272 Phase 4 Teicoplanin;Vancomycin
15 PEG-rhG-CSF in Patients With Breast Cancer Receiving Chemotherapy to Prevent Neutropenia Completed NCT02805205 Phase 4 PEG-rhG-CSF
16 Omalizumab to Mepolizumab Switch Study in Severe Eosinophilic Asthma Patients Completed NCT02654145 Phase 4 Mepolizumab 100mg SC;Albuterol/salbutamol MDIs;Omalizumab
17 Study of Cabazitaxel Combined With Prednisone and Prophylaxis of Neutropenia Complications in the Treatment of Patients With Metastatic Castration-resistant Prostate Cancer Completed NCT01649635 Phase 4 CABAZITAXEL (XRP6258);Prednisone;Ciprofloxacin;G-CSF (Granulocyte colony-stimulating factor)
18 A Study to Find Out How Safe and Effective Gammaplex® is in Young People With Primary Immunodeficiency Completed NCT01289847 Phase 4
19 Value of the LightCycler® SeptiFast Test MGRADE for the Pathogen Detection in Neutropenic Hematological Patients Completed NCT01114165 Phase 4
20 Safety of Cotrimoxazole in HIV- and HAART-exposed Infants Completed NCT01086878 Phase 4 cotrimoxazole
21 Oral Posaconazole in High Risk Patients With Gastrointestinal Dysfunction (Study P05115) Completed NCT00686543 Phase 4 Posaconazole
22 Diagnosis of Septicaemia by Detection of Microbial DNA in Blood in Severe Infections Completed NCT00709358 Phase 4
23 The Efficacy of Three Months-prednisolone Therapy for Chronic Eosinophilic Pneumonia Completed NCT00632554 Phase 4 prednisolone 0.5 mg/kg/day for three months;prednisolone 0.5 mg/kg/day for six months
24 A Study of Primary Prophylaxis With Neulasta (Pegfilgrastim) Versus Secondary Prophylaxis After Chemotherapy in Elderly Subjects (>/= 65 Years Old) With Cancer Completed NCT00277160 Phase 4 Neulasta (pegfilgrastim)
25 A Phase IV Study of Recombinant Human Gamma Interferon in Patients With Chronic Granulomatous Diseases of Childhood Completed NCT00001317 Phase 4 interferon-gamma
26 Steroid Treatment for Hypereosinophilic Syndrome Recruiting NCT01524536 Phase 4 Corticosteroids
27 Blood Draw Validation for Ciprofloxacin Pharmacokinetic Research in Pediatric Cancer Patients Recruiting NCT02967341 Phase 4
28 Granulocyte-colony Stimulating Factors or Antibiotics for Primary Prophylaxis for Febrile Neutropenia Recruiting NCT02816112 Phase 4 Ciprofloxacin;Neupogen
29 Steady-State Comparative Bioavailability Study in Prophylaxis Patients of Lozanoc® 50 mg With Sporanox® 100 mg Recruiting NCT02621905 Phase 4 Sporanox;Lozanoc
30 PEG-rhG-CSF in Patients With Non-Hodgkin Lymphoma Receiving Chemotherapy to Prevent Neutropenia Recruiting NCT02996617 Phase 4 rhG-CSF regimen;Pegylated rhG-CSF regimen
31 A Study to Compare Administration Schedules of G-CSF (Filgrastim) for Primary Prophylaxis of Febrile Neutropenia Recruiting NCT02816164 Phase 4 Neupogen
32 Budesonide Versus Fluticasone for Treatment of Eosinophilic Esophagitis Active, not recruiting NCT02019758 Phase 4 Oral Viscous Budesonide;Fluticasone MDI;Placebo slurry;Placebo inhaler
33 Posaconazole Versus Micafungin for Prophylaxis Against Invasive Fungal Infections During Neutropenia in Patients Undergoing Chemotherapy for Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia or Myelodysplastic Syndrome Active, not recruiting NCT01200355 Phase 4 micafungin;posaconazole
34 To Evaluate the Efficacy and Safety of PEG-rhG-CSF(Jinyouli®) in Reducing Neutropenia in Patients With Cervical Cancer Not yet recruiting NCT03206684 Phase 4 PEG-rhG-CSF;rhG-CSF
35 Immunogenicity, Safety, and Efficacy of Zarzio®/Filgrastim HEXAL® in Patients With Severe Chronic Neutropenia Terminated NCT01859637 Phase 4
36 SubCutaneous (SC) Versus Intravenous (IV) Granulocyte Colony Stimulating Factors (G-CSF) for the Treatment of Neutropenia in Hospitalized Haemato-oncological Patients Terminated NCT01222819 Phase 4 filgrastim
37 Ambisome and Management of Culture-negative Neutropenic Fever Unresponsive to Antibiotics Terminated NCT00421187 Phase 4 Liposomal amphotericin B (AmBisome®);Liposomal amphotericin B (AmBisome®)
38 Comparison of 2 Antifungal Treatment (Empirical Versus Pre-Empirical) Strategies in Prolonged Neutropenia Terminated NCT00190463 Phase 4 Amphotericin B
39 The Frequency of Eosinophilic Esophagitis in Patients With Heartburn That is Refractory to Proton Pump Inhibitors Terminated NCT01404832 Phase 4 Treat with lansoprazole 30 mg BID for 2 weeks, endoscopic examination with esophageal biopsy for patients with persistent symptoms
40 Biochemical Response to Interferon-Gamma in Subjects With Specific Gene Mutation in Chronic Granulomatous Disease Terminated NCT01147042 Phase 4 IFN-gamma
41 Treatment of Anemia and Neutropenia in HIV/HCV Coinfected Patients Treated With Pegylated Interferon and Ribavirin Terminated NCT00194857 Phase 4 erythropoietin, GCSF
42 Effect on Orencia (Abatacept) on the Apoptosis of T Cells, B Cells and APC Cells in Rheumatoid Arthritis Withdrawn NCT01717846 Phase 4 Group 1 or Orencia treated group
43 Comparing Ciprofloxacin (CPFX) With Cefepime (CFPM) in Febrile Neutropenic Patients With Hematologic Diseases Unknown status NCT00137787 Phase 3 ciprofloxacin;cefepime
44 Combination Chemotherapy, Biological Therapy, and Bone Marrow Transplantation in Treating Patients With Acute Myeloid Leukemia Unknown status NCT00002658 Phase 3 amsacrine;cyclophosphamide;cytarabine;daunorubicin hydrochloride;etoposide;idarubicin;mitoxantrone hydrochloride;thioguanine;tretinoin
45 Anti-Interleukin-5 (IL5) Monoclonal Antibody (MAb) in Prednisone-dependent Eosinophilic Asthma Unknown status NCT02559791 Phase 2, Phase 3 Placebo
46 Pegfilgrastim on Day +3 Compared to Day +1 After Salvage Chemotherapy for Patients With Refractory or Relapsed Aggressive Lymphoma Unknown status NCT02238873 Phase 3 Pegfilgrastim
47 Eosinophilic Esophagitis Treatment: Montelukast vs Fluticasone Unknown status NCT01702701 Phase 3 Montelukast;Fluticasone
48 A Study of Pegylated rhG-CSF as Support to Advanced Non-Small-Cell Lung Cancer (NSCLC) Patients Receiving Chemotherapy Receiving Chemotherapy Unknown status NCT01560195 Phase 3 Pegylated rhG-CSF: 100µg/kg;Pegylated rhG-CSF: 6mg;placebo and rhG-CSF 5ug/kg/d
49 Early Hospital Discharge or Standard Inpatient Care in Cancer Patients Receiving Antibiotics for Febrile Neutropenia Unknown status NCT00445497 Phase 3 amoxicillin-clavulanate potassium;ciprofloxacin
50 Levofloxacin Compared With Cefepime in Treating Cancer Patients With Fever and Neutropenia Unknown status NCT00020865 Phase 3 cefepime hydrochloride;levofloxacin

Search NIH Clinical Center for Leukocyte Disease

Cochrane evidence based reviews: leukocyte disorders

Genetic Tests for Leukocyte Disease

Genetic tests related to Leukocyte Disease:

# Genetic test Affiliating Genes
1 Abnormality of Leukocytes 28

Anatomical Context for Leukocyte Disease

Publications for Leukocyte Disease

Variations for Leukocyte Disease

Expression for Leukocyte Disease

Search GEO for disease gene expression data for Leukocyte Disease.

Pathways for Leukocyte Disease

Pathways related to Leukocyte Disease according to GeneCards Suite gene sharing:

(show all 42)
# Super pathways Score Top Affiliating Genes
Show member pathways
14.05 CCL11 CD34 CD40LG CSF2 CSF3 CSF3R
Show member pathways
13.87 CCL11 CD40LG CSF2 CSF3 CSF3R IL13
Show member pathways
13.71 CCL11 CD40LG CSF2 CSF3 CSF3R IL13
Show member pathways
13.52 CCL11 IL13 IL2 IL3 IL4 IL5
Show member pathways
13.4 CCL11 CD40LG CSF2 CSF3 CSF3R IL13
Show member pathways
13.36 CCL11 CD40LG CSF2 CSF3 CSF3R IL13
Show member pathways
13.3 CCL11 CD40LG CSF2 CSF3 CSF3R IL13
Show member pathways
13.04 CSF3 CSF3R G6PC3 IL2 IL3 IL4
Show member pathways
12.92 CCL11 CD40LG IL13 IL2 IL3 IL4
10 12.89 CSF3R IL13 IL2 IL3 IL4 IL5
11 12.63 CD34 CD40LG IL2 IL3 IL4 KIT
Show member pathways
12.6 CSF2 IL13 IL3 IL4 IL5
Show member pathways
12.46 CD40LG CSF2 IL2 IL4 IL5
Show member pathways
12.42 CCL11 CSF2 CSF3 IL13 IL4 IL5
Show member pathways
12.41 IL13 IL2 IL5 PDGFRA
Show member pathways
12.29 CSF2 CSF3 CSF3R IL13 IL2 IL3
Show member pathways
12.24 IL13 IL2 IL3 IL4 IL5
Show member pathways
12.15 CSF2 IL2 IL3 IL5
Show member pathways
12.06 IL13 IL2 IL5 TLR9
20 11.9 CSF2 IL13 IL2 IL4 IL5
21 11.87 CD34 IL13 IL2 IL4 IL5 KIT
Show member pathways
11.84 CD40LG CSF2 IL2 IL3 IL4 IL5
23 11.82 CD34 CSF2 IL2 KIT TLR9
24 11.77 CD40LG IL4 IL5 TLR9
25 11.75 CD34 ELANE KIT
26 11.75 CCL11 CD40LG IL4 IL5
27 11.74 CD34 CSF2 CSF3 CSF3R IL3 IL4
28 11.71 CCL11 CSF2 CSF3 IL13 IL4 IL5
Show member pathways
11.65 CD40LG CSF2 IL2
30 11.63 CSF2 CSF3 IL13 IL4
31 11.62 CSF2 CSF3 IL3 IL5
32 11.6 CCL11 IL13 IL2 IL4 IL5
33 11.58 CD34 CD40LG KIT
34 11.54 CD40LG CSF3 TLR9
35 11.42 CD40LG IL2 IL4 IL5
36 11.34 IL13 IL4 IL5
37 11.34 CD34 CSF2 CSF3 CSF3R IL2 IL3
38 11.3 IL13 IL2 IL4 IL5
39 11.21 CCL11 CD40LG CSF2 CSF3 IL13 IL2
40 11.01 CCL11 CD40LG CSF2 CSF3 IL13 IL2
41 10.98 CSF2 CSF3 IL13 IL2 IL3 IL4
42 10.9 IL13 IL4 IL5

GO Terms for Leukocyte Disease

Cellular components related to Leukocyte Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 CCL11 CD34 CD40LG CSF2 CSF3 CSF3R
2 external side of plasma membrane GO:0009897 9.46 CD34 CD40LG IL13 KIT
3 extracellular space GO:0005615 9.44 CCL11 CD40LG CSF2 CSF3 ELANE IL13

Biological processes related to Leukocyte Disease according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.95 CCL11 CD40LG IL13 IL5 KIT TLR9
2 positive regulation of cell proliferation GO:0008284 9.91 CSF2 CSF3 IL2 IL3 IL5 KIT
3 positive regulation of protein kinase B signaling GO:0051897 9.87 CSF3 HAX1 KIT PDGFRA
4 peptidyl-tyrosine phosphorylation GO:0018108 9.83 CSF2 IL3 IL5 KIT PDGFRA
5 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.8 CSF3 HAX1 IL3 IL5
6 cytokine-mediated signaling pathway GO:0019221 9.8 CSF3 CSF3R IL3 IL5 KIT
7 MAPK cascade GO:0000165 9.8 CSF2 IL2 IL3 IL5 KIT PDGFRA
8 positive regulation of T cell proliferation GO:0042102 9.77 CD40LG IL2 IL4
9 negative regulation of neuron death GO:1901215 9.76 CD34 CSF3 IL13
10 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.76 CSF3 HAX1 KIT PDGFRA
11 positive regulation of DNA replication GO:0045740 9.73 CSF2 IL3 PDGFRA
12 cellular response to cytokine stimulus GO:0071345 9.7 CSF3 HAX1 IL13
13 positive regulation of interleukin-10 production GO:0032733 9.69 CD34 CD40LG TLR9
14 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.65 CSF2 IL13 IL2 IL3 KIT
15 positive regulation of podosome assembly GO:0071803 9.63 CSF2 IL5
16 positive regulation of immunoglobulin secretion GO:0051024 9.63 IL2 IL5
17 dendritic cell differentiation GO:0097028 9.62 CSF2 IL4
18 regulation of myeloid cell differentiation GO:0045637 9.62 CSF2 CSF3R
19 positive regulation of isotype switching to IgG isotypes GO:0048304 9.61 IL2 IL4
20 positive regulation of phospholipase C activity GO:0010863 9.61 KIT PDGFRA
21 immune response GO:0006955 9.61 CCL11 CD40LG CSF2 CSF3 IL13 IL2
22 positive regulation of immunoglobulin production GO:0002639 9.6 IL13 TLR9
23 mast cell chemotaxis GO:0002551 9.58 CCL11 KIT
24 neutrophil differentiation GO:0030223 9.55 CSF2 CSF3
25 positive regulation of B cell proliferation GO:0030890 9.55 IL13 IL2 IL4 IL5 TLR9
26 negative regulation of complement-dependent cytotoxicity GO:1903660 9.54 IL13 IL4
27 regulation of receptor activity GO:0010469 9.28 CCL11 CD40LG CSF2 CSF3 IL13 IL2

Molecular functions related to Leukocyte Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.65 CSF2 IL3 IL5 KIT PDGFRA
2 growth factor activity GO:0008083 9.63 CSF2 CSF3 IL2 IL3 IL4 IL5
3 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.43 CSF2 IL2 IL3 IL5 KIT PDGFRA
4 cytokine activity GO:0005125 9.28 CCL11 CD40LG CSF2 CSF3 IL13 IL2

Sources for Leukocyte Disease

9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
51 Novoseek
54 OMIM via Orphanet
58 PubMed
66 SNOMED-CT via Orphanet
68 Tocris
70 UMLS via Orphanet
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