MCID: LKC003
MIFTS: 43

Leukocyte Disease malady

Categories: Blood diseases

Aliases & Classifications for Leukocyte Disease

Summaries for Leukocyte Disease

MalaCards based summary : Leukocyte Disease, also known as leukocyte disorders, is related to choledochal cyst and exudative vitreoretinopathy 2, x-linked. An important gene associated with Leukocyte Disease is IL5 (Interleukin 5), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Dopamine and Dexamethasone have been mentioned in the context of this disorder. Related phenotypes are hematopoietic system and immune system

Related Diseases for Leukocyte Disease

Diseases related to Leukocyte Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 138)
id Related Disease Score Top Affiliating Genes
1 choledochal cyst 10.4 CSF2 IL3 IL5
2 exudative vitreoretinopathy 2, x-linked 10.4 CSF2 IL13 IL5
3 lagophthalmos 10.4 FIP1L1 IL4 PDGFRA
4 ganglioneuroma 10.4 FIP1L1 KIT PDGFRA
5 spastic diplegia 10.4 CCL11 IL13 IL5
6 cutaneous fibrous histiocytoma 10.4 CCL11 IL4 IL5
7 disordered steroidogenesis due to cytochrome p450 oxidoreductase 10.4 CCL11 IL13 IL5
8 bone peripheral neuroepithelioma 10.4 IL13 IL4 IL5
9 marasmus 10.4 IL4 IL5 RNASE3
10 olfactory nerve disease 10.4 FIP1L1 KIT PDGFRA
11 indian plum allergy 10.4 IL13 IL4 IL5
12 lens-induced iridocyclitis 10.4 IL4 IL5 RNASE3
13 latent syphilis 10.4 CCL11 IL5 RNASE3
14 renal hypertension 10.4 IL13 IL5 RNASE3
15 askin's tumor 10.4 IL13 IL4 IL5
16 anterior dislocation of lens 10.3 CCL11 IL4 RNASE3
17 weaver syndrome 10.3 FIP1L1 PDGFRA RNASE3
18 hyperandrogenism due to cortisone reductase deficiency 10.3 FIP1L1 KIT PDGFRA
19 neurofibroma of gallbladder 10.3 CD34 KIT
20 dahlberg borer newcomer syndrome 10.3 IL13 IL5
21 hypersensitivity vasculitis 10.3 CD40LG IL4 IL5
22 duodenal somatostatinoma 10.3 IL13 IL4 IL5
23 gallbladder leiomyosarcoma 10.3 CD34 KIT
24 orbit alveolar rhabdomyosarcoma 10.3 IL4 IL5 RNASE3
25 lactose intolerance 10.3 CSF2 IL13 IL4 IL5
26 may-thurner syndrome 10.3 IL13 KIT PDGFRA
27 lymphoblastic leukemia 10.3 CCL11 IL13 IL4 IL5
28 restrictive cardiomyopathy 10.3 FIP1L1 IL5 PDGFRA RNASE3
29 loiasis 10.3 IL13 IL4 IL5
30 cerebral primitive neuroectodermal tumor 10.3 CCL11 IL4 IL5 RNASE3
31 apricot allergy 10.3 CCL11 IL4 IL5 RNASE3
32 abnormal retinal correspondence 10.3 IL2 IL4 IL5
33 luminal breast carcinoma 10.3 IL13 IL4 IL5 RNASE3
34 acute gonococcal prostatitis 10.3 IL13 IL4 IL5 RNASE3
35 infectious anterior uveitis 10.3 ELANE IL5 RNASE3
36 abca12-related autosomal recessive congenital ichthyosis 10.3 CSF3 ELANE
37 invasive mole 10.3 KIT PDGFRA
38 astrocytoma 10.3 CD40LG IL5 RNASE3
39 pericoronitis 10.3 IL2 IL3 KIT
40 temporomandibular ankylosis 10.3 FIP1L1 KIT PDGFRA
41 paratyphoid fever 10.3 IL13 IL4 IL5 RNASE3
42 wilkes stevenson syndrome 10.3 IL2 IL5 RNASE3
43 tularemia 10.3 CD40LG IL2 IL4
44 cerebral arterial disease 10.3 CD34 KIT PDGFRA
45 metal allergy 10.3 IL13 IL3 IL5 RNASE3
46 speech disorder 10.3 CD34 KIT
47 grix blankenship peterson syndrome 10.3 CSF2 CSF3 IL3
48 dengue hemorrhagic fever 10.3 IL13 IL2 IL4 IL5
49 barbiturate abuse 10.3 CCL11 CD40LG IL4
50 autosomal recessive congenital methemoglobinemia 10.3 IL13 IL2 IL5

Comorbidity relations with Leukocyte Disease via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Heart Disease

Graphical network of the top 20 diseases related to Leukocyte Disease:



Diseases related to Leukocyte Disease

Symptoms & Phenotypes for Leukocyte Disease

MGI Mouse Phenotypes related to Leukocyte Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.31 IL4 IL5 KIT PDGFRA CCL11 CD34
2 immune system MP:0005387 10.24 CCL11 CD34 CD40LG CSF2 CSF3 CSF3R
3 homeostasis/metabolism MP:0005376 10.18 CSF2 ELANE G6PC3 IL13 IL2 IL4
4 endocrine/exocrine gland MP:0005379 10.16 CD40LG CSF2 G6PC3 HAX1 IL13 IL2
5 mortality/aging MP:0010768 10.07 CD40LG CSF2 CSF3R ELANE G6PC3 HAX1
6 integument MP:0010771 9.97 CD34 CD40LG CSF2 CSF3 IL13 IL4
7 neoplasm MP:0002006 9.7 ELANE IL2 IL5 KIT PDGFRA CD34
8 reproductive system MP:0005389 9.61 CD40LG CSF2 IL13 IL2 IL4 IL5
9 respiratory system MP:0005388 9.23 PDGFRA CCL11 CSF2 IL13 IL2 IL4

Drugs & Therapeutics for Leukocyte Disease

Drugs for Leukocyte Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1030)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 3,Phase 2 51-61-6, 62-31-7 681
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-02-2 5743
3
Doxorubicin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 23214-92-8 31703
4
Pioglitazone Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 111025-46-8 4829
5
Zinc Approved Phase 4,Phase 3,Phase 1,Phase 2 7440-66-6 32051 23994
6
Cyclosporine Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 79217-60-0, 59865-13-3 5284373 6435893
7
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 104987-11-3 445643 439492
8
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-78-2 2244
9
Mitoxantrone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 65271-80-9 4212
10
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757 53477783
11
Daunorubicin Approved Phase 4,Phase 3,Phase 2,Phase 1 20830-81-3 30323
12
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 2068-78-2, 57-22-7 5978
13
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1 33419-42-0 36462
14
Cisplatin Approved Phase 4,Phase 3,Phase 2 15663-27-1 84093 441203 2767
15
Cytarabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 147-94-4 6253
16
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1 1959-05-2, 59-05-2 126941
17
Efavirenz Approved, Investigational Phase 4,Phase 2,Phase 1 154598-52-4 64139
18
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-18-0, 6055-19-2 2907
19
Midazolam Approved, Illicit Phase 4,Phase 2 59467-70-8 4192
20
Gemcitabine Approved Phase 4,Phase 2,Phase 3,Phase 1 95058-81-4 60750
21
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2,Phase 1 24280-93-1 446541
22
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 128794-94-5 5281078
23
Ciprofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2 85721-33-1 2764
24
Morphine Approved, Investigational Phase 4,Phase 2 57-27-2 5288826
25
Lamivudine Approved, Investigational Phase 4,Phase 2,Phase 1 134678-17-4 60825
26
Metformin Approved Phase 4,Phase 2,Phase 3 657-24-9 14219 4091
27
Enalapril Approved, Vet_approved Phase 4 75847-73-3 5362032 40466924
28
Enalaprilat Approved Phase 4 76420-72-9 6917719
29
Metoprolol Approved, Investigational Phase 4,Phase 2 37350-58-6, 51384-51-1 4171
30
Busulfan Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 55-98-1 2478
31
Ribavirin Approved Phase 4,Phase 3,Phase 2 36791-04-5 37542
32
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 185243-69-0
33
Hydrocortisone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-23-7 5754 657311
34
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-24-8 5755
35
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 22916-47-8 4189
36
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
37
Budesonide Approved Phase 4,Phase 2,Phase 3 51333-22-3 63006 5281004
38
Desogestrel Approved Phase 4 54024-22-5 40973
39
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 1 26787-78-0 33613 2171
40
Sulpiride Approved Phase 4 15676-16-1 5355
41
Sertraline Approved Phase 4 79617-96-2 68617
42
Thiotepa Approved Phase 4,Phase 3,Phase 2,Phase 1 52-24-4 5453
43
Lenograstim Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 135968-09-1
44
Triamcinolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 124-94-7 31307
45
Lansoprazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 103577-45-3 3883
46
Voriconazole Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 137234-62-9 71616
47
Micafungin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 235114-32-6 3081921 477468
48
Linezolid Approved, Investigational Phase 4,Phase 3,Phase 2 165800-03-3 441401
49
Omalizumab Approved, Investigational Phase 4,Phase 2,Phase 1 242138-07-4
50
Benzocaine Approved Phase 4,Phase 3,Phase 2,Phase 1 1994-09-7, 94-09-7 2337

Interventional clinical trials:

(show top 50) (show all 2889)
id Name Status NCT ID Phase
1 Micafungin Prevention Study for Fungal Disease in Child Receiving Allogenic Hematopoietic Stem Cell Transplantation Unknown status NCT01135589 Phase 4
2 Prevention of Neutropenia After Using G-CSF With TAC Chemotherapy Unknown status NCT01571518 Phase 4
3 Oral Cromolyn Sodium for the Treatment of Eosinophilic Esophagitis Unknown status NCT02371941 Phase 4
4 Dietetic Versus Topical Steroids for Pediatric Eosinophilic Esophagitis Unknown status NCT01846962 Phase 4
5 Filgrastim or Pegfilgrastim in Preventing Neutropenia in Women Receiving Chemotherapy Following Surgery for Breast Cancer Unknown status NCT00030758 Phase 4
6 Efficacy and Safety of Mitoxantrone in Patients With Refractory Neuromyelitis Optica and Spectrum Disorders Unknown status NCT02021825 Phase 4
7 Preliminary Study to Investigate the Effect of rTMS and SSRI Antidepressants on Leukocyte Expression of the C-FOS and DUSP1 Genes in Patients Treated for Depression Unknown status NCT02042573 Phase 4
8 Randomized, Double-blind, Placebo-controlled Study to Evaluate the Effect of Roflumilast on Endothelial Function in Patients With Chronic Obstructive Pulmonary Disease Unknown status NCT01595750 Phase 4
9 Association of Amisulpride Response in Schizophrenia With Brain Image Unknown status NCT02095938 Phase 4
10 Anti-Hypertensive Agent (ACEi) and Heart Function Improvement in Association With Rho Kinase Activity Changes in Human Unknown status NCT01069042 Phase 4
11 Remission Induction in Very Early Rheumatoid Arthritis Unknown status NCT00523692 Phase 4
12 Steroids Pharmacokinetics and the Response to Prednisone Therapy in Giant Cell Arteritis Unknown status NCT01400464 Phase 4
13 Effect of Midazolam on Inflammatory Response and Organ Function in Mechanically Ventilated Sepsis Patients With Different Immune Status Unknown status NCT02135055 Phase 4
14 Atorvastatin, Aspirin, Oxidative Stress, Coagulation and Platelet Activation Indexes Unknown status NCT01322711 Phase 4
15 Effect of the Etonogestrel 0.12mg/Ethinyl Estradiol 0.015mg Vaginal Ring on Vaginal Innate and Inflammatory Biomarkers Unknown status NCT01448291 Phase 4
16 Improving Anti-malarial Treatment Options in Guinea-Bissau - Part A Unknown status NCT01704508 Phase 4
17 Assessment Of Gh-Igf-1 Axis In Children With Chronic Myelogenous Leukemia (CML) In Remission Unknown status NCT01901666 Phase 4
18 Effects of Raltegravir Based Regimen on Platelet Reactivity, Platelet-monocyte Aggregation and Immune Activation Unknown status NCT02383355 Phase 4
19 Effects of Sevoflurane in Subanesthetic Concentrations on the Forearm Perfusion Unknown status NCT00526695 Phase 4
20 Does a Single Steroid Injection Reduce the Formation of Postmastectomy Seroma Unknown status NCT00307606 Phase 4
21 Observational Study Investigating the Response Rate of Itraconazole Injection in Treating Immunocompromised Patients Completed NCT01060462 Phase 4
22 A Clinical Trial of Patients With Solid Tumours Receiving Granulocyte Colony Stimulating Factor as Primary Prophylaxis for Chemotherapy-induced Neutropenia, in a Docetaxel Based Regimen Completed NCT01107756 Phase 4
23 A Study of Empirical Antifungal Therapy With Itraconazole Completed NCT01706562 Phase 4
24 The Tobramycin Study Completed NCT00257790 Phase 4
25 FIRST - Study of Pegfilgrastim Administered in the First and Subsequent Cycles of Myelosuppressive Chemotherapy Completed NCT00125723 Phase 4
26 Study to Reduce Duration of Antibiotic Therapy in Haematological Patients With Fever and Neutropenia Completed NCT01581333 Phase 4
27 The Relationship of Defeverscence and Itraconazole Plasma Level Study in Immunocompromised Participants Completed NCT01021683 Phase 4
28 Comparison of the Pharmacodynamics of Imipenem in Patients With Febrile Neutropenia Completed NCT02213783 Phase 4
29 Pharmacokinetic/Pharmacodynamic Study of Doripenem in Febrile Neutropenic Patients Completed NCT01401010 Phase 4
30 Comparison of Teicoplanin and Vancomycin in Initial Empirical Antibiotic Regimen for Febrile Neutropenic Patients Completed NCT00454272 Phase 4
31 A Phase IV Study of Recombinant Human Gamma Interferon in Patients With Chronic Granulomatous Diseases of Childhood Completed NCT00001317 Phase 4
32 A Study to Find Out How Safe and Effective Gammaplex® is in Young People With Primary Immunodeficiency Completed NCT01289847 Phase 4
33 The Efficacy of Three Months-prednisolone Therapy for Chronic Eosinophilic Pneumonia Completed NCT00632554 Phase 4
34 Diagnosis of Septicaemia by Detection of Microbial DNA in Blood in Severe Infections Completed NCT00709358 Phase 4
35 Value of the LightCycler® SeptiFast Test MGRADE for the Pathogen Detection in Neutropenic Hematological Patients Completed NCT01114165 Phase 4
36 Oral Posaconazole in High Risk Patients With Gastrointestinal Dysfunction (Study P05115) Completed NCT00686543 Phase 4
37 Safety of Cotrimoxazole in HIV- and HAART-exposed Infants Completed NCT01086878 Phase 4
38 A Study of Primary Prophylaxis With Neulasta (Pegfilgrastim) Versus Secondary Prophylaxis After Chemotherapy in Elderly Subjects (>/= 65 Years Old) With Cancer Completed NCT00277160 Phase 4
39 PEG-rhG-CSF in Patients With Breast Cancer Receiving Chemotherapy to Prevent Neutropenia Completed NCT02805205 Phase 4
40 Study of Cabazitaxel Combined With Prednisone and Prophylaxis of Neutropenia Complications in the Treatment of Patients With Metastatic Castration-resistant Prostate Cancer Completed NCT01649635 Phase 4
41 A Study of Risk Factors for Anti-erythropoietin Antibody Positive Pure Red Cell Aplasia Among Patients With Chronic Kidney Disease Receiving Epoetin Alfa Completed NCT00211068 Phase 4
42 Angioplasty in Peripheral Arterial Disease and Endothelial Function Completed NCT00660634 Phase 4
43 CYP2C19 Genetic Polymorphism on the Accuracy of Proton-Pump Inhibitor Testing Completed NCT00354757 Phase 4
44 Safety, Immunogenicity And Efficacy Of Vaccination In Military Personnel Completed NCT01807780 Phase 4
45 Assessment of Translesional Markers and Metabolomics Completed NCT00321139 Phase 4
46 Study to Monitor the Incidence of Pure Red Cell Aplasia (PRCA) and/or Antibodies to Erythropoietin Among Participants Receiving Epoetin Alfa or Another Erythropoietin Completed NCT00210951 Phase 4
47 A Study of Aripiprazole (Abilify) in Patients With Bipolar Mania Completed NCT00261443 Phase 4
48 Saxagliptin and Atherosclerosis Completed NCT01552018 Phase 4
49 Varenicline Effects In Schizophrenic Smokers Completed NCT00548470 Phase 4
50 Time To Efficacy and Onset Of Action Of Linezolid Completed NCT00147511 Phase 4

Search NIH Clinical Center for Leukocyte Disease

Cochrane evidence based reviews: leukocyte disorders

Genetic Tests for Leukocyte Disease

Genetic tests related to Leukocyte Disease:

id Genetic test Affiliating Genes
1 Abnormality of Leukocytes 29

Anatomical Context for Leukocyte Disease

Publications for Leukocyte Disease

Variations for Leukocyte Disease

Expression for Leukocyte Disease

Search GEO for disease gene expression data for Leukocyte Disease.

Pathways for Leukocyte Disease

Pathways related to Leukocyte Disease according to GeneCards Suite gene sharing:

(show all 38)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.05 CCL11 CD34 CD40LG CSF2 CSF3 CSF3R
2
Show member pathways
13.88 CCL11 CD40LG CSF2 CSF3 CSF3R IL13
3
Show member pathways
13.68 CCL11 CD40LG CSF2 CSF3 CSF3R IL13
4
Show member pathways
13.51 CCL11 IL13 IL2 IL3 IL4 IL5
5
Show member pathways
13.43 CCL11 CD40LG CSF2 CSF3 CSF3R IL13
6
Show member pathways
13.37 CCL11 CD40LG CSF2 CSF3 CSF3R IL13
7
Show member pathways
13.25 CCL11 CD40LG CSF2 CSF3 CSF3R IL13
8
Show member pathways
12.89 CCL11 CD40LG IL13 IL2 IL3 IL4
9 12.66 CSF3 CSF3R G6PC3 IL2 IL3 IL4
10 12.59 CD34 CD40LG IL2 IL3 IL4 KIT
11
Show member pathways
12.58 CSF2 IL13 IL3 IL4 IL5
12
Show member pathways
12.45 CD40LG CSF2 IL2 IL4 IL5
13
Show member pathways
12.4 IL13 IL2 IL5 PDGFRA
14
Show member pathways
12.4 CCL11 CSF2 CSF3 IL13 IL4 IL5
15
Show member pathways
12.21 IL13 IL2 IL3 IL4 IL5
16
Show member pathways
12.16 CSF2 CSF3 CSF3R IL13 IL2 IL3
17
Show member pathways
12.14 CSF2 IL2 IL3 IL5
18 11.87 CSF2 IL13 IL2 IL4 IL5
19 11.84 CD34 IL13 IL2 IL4 IL5 KIT
20 11.81 CD34 CSF2 IL2 KIT
21
Show member pathways
11.79 CD40LG CSF2 IL2 IL3 IL4 IL5
22 11.74 CD34 ELANE KIT
23 11.74 CD34 CSF2 CSF3 CSF3R IL3 IL4
24 11.72 CCL11 CD40LG IL4 IL5
25 11.69 CD40LG IL4 IL5
26
Show member pathways
11.64 CD40LG CSF2 IL2
27 11.64 CCL11 CSF2 CSF3 IL13 IL4 IL5
28 11.61 CCL11 IL13 IL2 IL4 IL5
29 11.6 CSF2 CSF3 IL13 IL4
30 11.59 CSF2 CSF3 IL3 IL5
31 11.56 CD34 CD40LG KIT
32 11.4 CD40LG IL2 IL4 IL5
33 11.34 CD34 CSF2 CSF3 CSF3R IL2 IL3
34 11.33 IL13 IL4 IL5
35 11.26 IL13 IL2 IL4 IL5
36 11.14 CCL11 CD40LG CSF2 CSF3 IL13 IL2
37 10.98 IL13 IL4 IL5
38 10.98 CSF2 CSF3 IL13 IL2 IL3 IL4

GO Terms for Leukocyte Disease

Cellular components related to Leukocyte Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.77 CCL11 CD34 CD40LG CSF2 CSF3 CSF3R
2 external side of plasma membrane GO:0009897 9.63 CD34 CD40LG IL13 IL4 KIT PDGFRA
3 extracellular space GO:0005615 9.4 CCL11 CD40LG CSF2 CSF3 ELANE IL13

Biological processes related to Leukocyte Disease according to GeneCards Suite gene sharing:

(show all 31)
id Name GO ID Score Top Affiliating Genes
1 peptidyl-tyrosine phosphorylation GO:0018108 9.88 CSF2 IL3 IL5 KIT PDGFRA
2 MAPK cascade GO:0000165 9.88 CSF2 IL2 IL3 IL5 KIT PDGFRA
3 positive regulation of cell proliferation GO:0008284 9.86 CSF2 CSF3 IL2 IL3 IL4 IL5
4 response to ethanol GO:0045471 9.85 CSF3 IL13 IL2 IL4
5 cytokine-mediated signaling pathway GO:0019221 9.83 CSF3 CSF3R IL3 IL5 KIT
6 positive regulation of T cell proliferation GO:0042102 9.79 CD40LG IL2 IL4
7 negative regulation of neuron death GO:1901215 9.77 CD34 CSF3 IL13
8 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.76 CSF3 HAX1 KIT PDGFRA
9 positive regulation of DNA replication GO:0045740 9.75 CSF2 IL3 PDGFRA
10 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.72 CSF3 HAX1 IL3 IL4 IL5
11 cellular response to cytokine stimulus GO:0071345 9.7 CSF3 HAX1 IL13
12 positive regulation of interleukin-10 production GO:0032733 9.69 CD34 CD40LG IL4
13 positive regulation of B cell proliferation GO:0030890 9.67 IL13 IL2 IL4 IL5
14 microglial cell activation GO:0001774 9.65 IL13 IL4
15 negative regulation of nitric oxide biosynthetic process GO:0045019 9.65 CD34 IL4
16 positive regulation of podosome assembly GO:0071803 9.64 CSF2 IL5
17 positive regulation of immunoglobulin secretion GO:0051024 9.64 IL2 IL5
18 dendritic cell differentiation GO:0097028 9.63 CSF2 IL4
19 positive regulation of isotype switching to IgG isotypes GO:0048304 9.63 IL2 IL4
20 positive regulation of mast cell degranulation GO:0043306 9.62 IL13 IL4
21 positive regulation of phospholipase C activity GO:0010863 9.62 KIT PDGFRA
22 positive regulation of immunoglobulin production GO:0002639 9.61 IL13 IL4
23 immune response GO:0006955 9.61 CCL11 CD40LG CSF2 CSF3 IL13 IL2
24 mast cell chemotaxis GO:0002551 9.58 CCL11 KIT
25 regulation of proton transport GO:0010155 9.57 IL13 IL4
26 negative regulation of T-helper 17 cell differentiation GO:2000320 9.56 IL2 IL4
27 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.55 CSF2 IL2 IL3 IL4 KIT
28 negative regulation of complement-dependent cytotoxicity GO:1903660 9.54 IL13 IL4
29 positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 9.02 CSF2 IL2 IL3 IL4 KIT
30 positive regulation of GTPase activity GO:0043547 10.04 CCL11 CSF2 IL2 IL3 IL5 KIT
31 inflammatory response GO:0006954 10 CCL11 CD40LG IL13 IL5 KIT

Molecular functions related to Leukocyte Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.65 CSF2 IL3 IL5 KIT PDGFRA
2 growth factor activity GO:0008083 9.63 CSF2 CSF3 IL2 IL3 IL4 IL5
3 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.43 CSF2 IL2 IL3 IL5 KIT PDGFRA
4 cytokine activity GO:0005125 9.28 CCL11 CD40LG CSF2 CSF3 IL13 IL2

Sources for Leukocyte Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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