Aliases & Classifications for Leukomalacia

MalaCards integrated aliases for Leukomalacia:

Name: Leukomalacia 49

Classifications:



Summaries for Leukomalacia

MalaCards based summary : Leukomalacia is related to periventricular leukomalacia and brain injury. An important gene associated with Leukomalacia is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Toll-Like receptor Signaling Pathways. The drugs Dopamine and Levodopa have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and heart, and related phenotypes are homeostasis/metabolism and cellular

Related Diseases for Leukomalacia

Diseases related to Leukomalacia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 123)
# Related Disease Score Top Affiliating Genes
1 periventricular leukomalacia 31.1 ALOX15 EPO IL1R1 IL6 MBP MYT1
2 brain injury 30.0 EPO IL6 MBP
3 fetal indomethacin syndrome 11.0
4 scorpion envenomation 10.6 IL6 TNF
5 angioimmunoblastic lymphadenopathy with dysproteinemia 10.5 IL6 TNF
6 critical limb ischemia 10.5 IL6 TNF
7 autoimmune myocarditis 10.5 SPP1 TNF
8 hemorrhagic fever 10.4 IL6 SLC17A5 TNF
9 nonalcoholic steatohepatitis 10.4 IL6 SLC17A5 TNF
10 endometritis 10.4 IL6 SLC17A5 TNF
11 eales disease 10.4 IL6 NOS2 TNF
12 cerebritis 10.4
13 ischemic heart disease 10.4 IL6 NPPB TNF
14 streptococcal toxic-shock syndrome 10.4 IL6 TNF
15 obstructive jaundice 10.4 IL6 SLC17A5 TNF
16 spinal cord injury 10.4 IL6 NOS2 TNF
17 pericarditis 10.4 IL6 NPPB TNF
18 alcoholic hepatitis 10.4 IL6 SLC17A5 TNF
19 transverse myelitis 10.4 IL6 MBP TNF
20 hydrocephalus due to congenital stenosis of aqueduct of sylvius 10.4 MBP NES
21 chlamydia 10.4 IL6 NOS2 TNF
22 myelitis 10.4 IL6 MBP TNF
23 null-cell leukemia 10.4 IL6 TNF
24 tympanosclerosis 10.4 NOS2 TNF
25 viral encephalitis 10.4 IL6 MBP TNF
26 post-transplant lymphoproliferative disease 10.3 IL1R1 IL6 TNF
27 sleep apnea 10.3 IL6 NPPB TNF
28 systemic onset juvenile idiopathic arthritis 10.3 IL18 TNF
29 vibrio vulnificus infection 10.3 EPO IL6
30 neuromyelitis optica 10.3 IL6 MBP SLC1A2
31 encephalomalacia 10.3 IL6 MBP MYT1
32 cryopyrin-associated periodic syndrome 10.3 IL1R1 IL6
33 adult respiratory distress syndrome 10.3 IL1R1 IL6 TNF
34 chorioamnionitis 10.3 IL1R1 IL6 TNF
35 arteries, anomalies of 10.3 IL6 NPPB TNF
36 kawasaki disease 10.3 IL6 NPPB TNF
37 stachybotrys chartarum 10.3 IL18 IL6 TNF
38 hepatic encephalopathy 10.3 IL6 SLC17A5 SLC1A2 TNF
39 pulpitis 10.3 IL18 IL6 TNF
40 fasciitis 10.3 IL18 IL6 TNF
41 cardiogenic shock 10.3 IL6 NPPB
42 uremic pruritus 10.3 IL18 IL6 SLC17A5
43 rasmussen encephalitis 10.3 IL18 IL6 TNF
44 chikungunya 10.3 IL18 IL6 TNF
45 paracoccidioidomycosis 10.3 IL18 IL6 TNF
46 melioidosis 10.2 IL18 IL6 TNF
47 brucellosis 10.2 IL18 IL6 TNF
48 poems syndrome 10.2 EPO IL6 TNF
49 cerebral palsy 10.2
50 myocarditis 10.2 IL6 NOS2 NPPB TNF

Graphical network of the top 20 diseases related to Leukomalacia:



Diseases related to Leukomalacia

Symptoms & Phenotypes for Leukomalacia

MGI Mouse Phenotypes related to Leukomalacia:

43 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.35 IL18 CHKA EPO IL1R1 GRM1 ALOX15
2 cellular MP:0005384 10.3 ALOX15 IL18 EPO IL1R1 GRM1 IL6
3 growth/size/body region MP:0005378 10.29 ALOX15 IL18 IL1R1 GRM1 IL6 NOS2
4 behavior/neurological MP:0005386 10.25 GRM1 IL18 MBP IL1R1 IL6 NOS2
5 mortality/aging MP:0010768 10.24 ALOX15 IL18 CHKA EPO IL1R1 GRM1
6 cardiovascular system MP:0005385 10.19 ALOX15 IL18 EPO IL1R1 IL6 NOS2
7 hematopoietic system MP:0005397 10.19 ALOX15 IL18 IL18R1 EPO MBP IL1R1
8 immune system MP:0005387 10.16 ALOX15 IL18 IL18R1 EPO MBP IL1R1
9 integument MP:0010771 10.09 ALOX15 IL18 EPO IL1R1 GRM1 IL6
10 adipose tissue MP:0005375 10.03 GRM1 IL18 IL1R1 IL6 NOS2 TNF
11 muscle MP:0005369 10.02 IL18 EPO IL1R1 GRM1 MYT1 IL6
12 liver/biliary system MP:0005370 9.95 CHKA EPO IL1R1 IL6 NOS2 TNF
13 nervous system MP:0003631 9.9 IL18 GRM1 IL6 NOS2 MBP IL1R1
14 neoplasm MP:0002006 9.8 ALOX15 IL1R1 GRM1 IL6 NOS2 TNF
15 reproductive system MP:0005389 9.56 GRM1 ALOX15 MBP IL6 NOS2 SPP1
16 vision/eye MP:0005391 9.23 GRM1 IL18 IL6 NOS2 MBP IL1R1

Drugs & Therapeutics for Leukomalacia

Drugs for Leukomalacia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 145)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 3,Phase 1 51-61-6, 62-31-7 681
2
Levodopa Approved Phase 4 59-92-7 6047
3
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4,Phase 3 7487-88-9 24083
4
Progesterone Approved, Vet_approved Phase 4,Phase 2,Phase 3 57-83-0 5994
5
Ibuprofen Approved Phase 4,Phase 3,Phase 2,Phase 1 15687-27-1 3672
6
Indomethacin Approved, Investigational Phase 4,Phase 1,Phase 2 53-86-1 3715
7 Poractant alfa Approved Phase 4 129069-19-8
8 Analgesics Phase 4,Phase 3,Phase 1,Phase 2
9 calcium channel blockers Phase 4,Phase 3
10 Respiratory System Agents Phase 4,Phase 3,Phase 2
11 Central Nervous System Depressants Phase 4,Phase 3
12 Tocolytic Agents Phase 4,Phase 3,Phase 1,Phase 2
13 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1
14 Anesthetics Phase 4,Phase 3
15 Dihydroxyphenylalanine Phase 4
16 Dopamine Agents Phase 4,Phase 3,Phase 1
17 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
18 Anti-Arrhythmia Agents Phase 4,Phase 3
19 Anticonvulsants Phase 4,Phase 3
20 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1
21 Pulmonary Surfactants Phase 4,Phase 3,Phase 2
22 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1
23 Carbidopa, levodopa drug combination Phase 4
24 Calcium, Dietary Phase 4,Phase 3,Phase 2
25 Progestins Phase 4,Phase 2,Phase 3
26 11-hydroxyprogesterone Phase 4,Phase 2,Phase 3
27 17-alpha-hydroxy-progesterone caproate Phase 4,Phase 2,Phase 3
28 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 1,Phase 2
29 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 1,Phase 2
30 Hormone Antagonists Phase 4,Phase 2,Phase 3
31 Hormones Phase 4,Phase 2,Phase 3
32 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3
33 Estrogen Antagonists Phase 4,Phase 2,Phase 3
34 Estrogens Phase 4,Phase 2,Phase 3
35 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 1,Phase 2
36 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 1,Phase 2
37 Antirheumatic Agents Phase 4,Phase 3,Phase 1,Phase 2
38 Caproate Nutraceutical Phase 4,Phase 2,Phase 3
39
Heparin Approved, Investigational Phase 3 9005-49-6 46507594 772
40
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
41
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
42
Phenobarbital Approved, Investigational Phase 3 50-06-6 4763
43
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
44
Betamethasone Approved, Vet_approved Phase 3 378-44-9 9782
45
Pentoxifylline Approved, Investigational Phase 3 6493-05-6 4740
46
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
47
Benzocaine Approved, Investigational Phase 2, Phase 3 1994-09-7, 94-09-7 2337
48
Dalteparin Approved Phase 3 9005-49-6
49 Simethicone Approved Phase 3
50
Nitric Oxide Approved Phase 2, Phase 3 10102-43-9 145068

Interventional clinical trials:

(show top 50) (show all 78)

# Name Status NCT ID Phase Drugs
1 Dopamine Treatment in Children With Cerebral Palsy With Dystonia- A Double Blind Controlled Study Unknown status NCT01361373 Phase 4 L- DOPA;placebo
2 Neuroprotection by Magnesium Sulfate Given to Women at Risk of Very Preterm Birth Completed NCT00120588 Phase 4 magnesium
3 Efficacy of 17 Alpha-hydroxyprogesterones Caproate for the Prevention of Preterm Delivery Completed NCT00331695 Phase 4 17 alpha-hydroxyprogesterones caproate
4 OPTIMIST-A Trial: Minimally-invasive Surfactant Therapy in Preterm Infants 25-28 Weeks Gestation on CPAP Recruiting NCT02140580 Phase 4
5 Comparing Ibuprofen And Indomethacin For The Treatment Of The Patent Ductus Arteriosus in Very Premature Babies Withdrawn NCT00470743 Phase 4 Ibuprofen;Indomethacin
6 Management of Hypotension In the Preterm Infant Unknown status NCT01482559 Phase 3 Dopamine hydrochloride;Dextrose 5%
7 Magnesium Sulfate to Prevent Brain Injury in Premature Infants Unknown status NCT00065949 Phase 3 magnesium sulfate
8 Tracheal Occlusion To Accelerate Lung Growth (TOTAL) Trial for Severe Pulmonary Hypoplasia Unknown status NCT01240057 Phase 2, Phase 3
9 Premature Infants in Need of Transfusion (PINT) Completed NCT00182390 Phase 3
10 Antenatal Phenobarbital to Prevent Neonatal Intracranial Hemorrhage Completed NCT00009620 Phase 3 Phenobarbital;Saline
11 Beneficial Effects of Antenatal Magnesium Sulfate (BEAM Trial) Completed NCT00014989 Phase 3 magnesium sulfate
12 17OHP for Reduction of Neonatal Morbidity Due to Preterm Birth (PTB) in Twin and Triplet Pregnancies Completed NCT00163020 Phase 2, Phase 3 17-alpha-hydroxyprogesterone caproate injectable;Placebo
13 Fluconazole Prophylaxis for the Prevention of Candidiasis in Infants Less Than 750 Grams Birthweight Completed NCT00734539 Phase 3 fluconazole;placebo
14 NIV Strategies for RDS in Preterm Infants. NIV (Non Invasive Ventilation), RDS (Respiratory Distress Syndrome) Completed NCT02259400 Phase 2, Phase 3
15 Surfactant Positive Airway Pressure and Pulse Oximetry Trial Completed NCT00233324 Phase 3 Surfactant;Supplemental oxygen with target saturation of 85 to 89%;Supplemental oxygen with target saturation of 91 to 95%
16 Caffeine for Apnea of Prematurity (CAP) Completed NCT00182312 Phase 3 Caffeine citrate injection
17 Pentoxifylline and Late Onset Sepsis in Preterm Infants Completed NCT02163174 Phase 3 Pentoxifylline (PTX);Placebo
18 High Versus Low Dose of Caffeine for Apnea of Prematurity Completed NCT02103777 Phase 3 Caffeine citrate
19 Safety and Efficacy Study of Ibuprofen l-Lysine Solution in Premature Infants for Treatment of PDA Completed NCT00440804 Phase 3 ibuprofen l-lysine iv solution (NeoProfen (R) )
20 Omega-3 Fatty Acid Supplementation to Prevent Preterm Birth in High Risk Pregnancies Completed NCT00135902 Phase 3 17 alpha-Hydroxyprogesterone Caproate and Omega-3 fish oils
21 Trial of Aggressive Versus Conservative Phototherapy in Infants <1,000 Grams Birth Weight Completed NCT00114543 Phase 3
22 Trial of Progesterone in Twins and Triplets to Prevent Preterm Birth (STTARS) Completed NCT00099164 Phase 3 17 alpha-hydroxyprogesterone caproate (17P)
23 Prevention of Maternal and Perinatal Complications by Enoxaparin in Women With Previous Severe Preeclampsia Completed NCT00986765 Phase 3 Lovenox® (enoxaparin);Aspegic ® (Aspirin)
24 Effect of Erythropoietin in Premature Infants on White Matter Lesions and Neurodevelopmental Outcome Recruiting NCT03110341 Phase 3 Erythropoietin;Normal saline
25 Dose Reduction of Antenatal Betamethasone Given to Prevent the Neonatal Complications Associated With Very Preterm Birth Recruiting NCT02897076 Phase 3 betamethasone 24 mg;12mg betamethasone +placebo
26 Maternal Omega-3 Supplementation to Reduce Bronchopulmonary Dysplasia Recruiting NCT02371460 Phase 3
27 Inhaled Nitric Oxide and Neuroprotection in Premature Infants Active, not recruiting NCT00515281 Phase 2, Phase 3 inhaled nitric oxide;oxygen
28 Efficacy and Safety of Goat Lung Surfactant for the Treatment of Respiratory Distress Syndrome in Preterm Neonates Not yet recruiting NCT02774044 Phase 2, Phase 3 Cadisurf;Survanta
29 Probiotics for the Prevention of Premature Birth and Neonatal Related Morbidity Terminated NCT00303082 Phase 3 Lactobacillus rhamnosus GR1 and Lactobacillus reuteri RC-14
30 Minimal Breathing Support and Early Steroids to Prevent Chronic Lung Disease in Extremely Premature Infants (SAVE) Terminated NCT00005777 Phase 3 Dexamethasone;Placebo
31 Recombinant Erythropoietin for Neuroprotection in Very Preterm Infants Unknown status NCT00910234 Phase 1, Phase 2 recombinant human erythropoietin (rhEpo);recombinant human erythropoietin (rhEpo);Normal saline
32 Minimally Invasive Surfactant Therapy Followed by CPAP (MISTCPAP) in Preterm Infants With RDS Unknown status NCT01723683 Phase 2 Surfactant
33 Does Erythropoietin Improve Outcome in Very Preterm Infants? Completed NCT00413946 Phase 2 Recombinant human Erythropoietin;saline
34 High-frequency Oscillatory Ventilation (HFOV) in Preterm Infants With Severe Respiratory Distress Syndrome (RDS) Completed NCT01496508 Phase 2
35 Effects of Delayed Cord Clamp and/or Indomethacin on Preterm Infant Brain Injury Recruiting NCT02221219 Phase 1, Phase 2 Indomethacin;placebo infusion
36 Randomized Trial of Maternal Progesterone Therapy Recruiting NCT02133573 Phase 2 Progesterone;Vaginal lubricant
37 The Synergistic Pharmacologic Intervention for Prevention of ROP (SPIPROP Study) Recruiting NCT02344225 Phase 2 Caffeine citrate;Ibuprofen;Ketorolac
38 Antibiotic "Dysbiosis" in Preterm Infants Recruiting NCT02784821 Phase 2 Antibiotic;Antibiotics - pre-emptive
39 'TOTAL' (Tracheal Occlusion To Accelerate Lung Growth) Trial Recruiting NCT02875860 Phase 2
40 Probiotics Reduce Incidence of Necrotizing Enterocolitis for Very Low Birth Weight Infants Terminated NCT00540033 Phase 2
41 Dobutamine in the Treatment of Haemodynamic Insufficiency in the Immediate Postnatal Period Terminated NCT03311178 Phase 1, Phase 2 Dobutamine
42 High-Dose Erythropoietin in Extremely Premature Infants to Prevent/Attenuate Brain Injury: A Phase II Study Terminated NCT00589953 Phase 2 Erythropoietin;Saline placebo
43 A Trial of Infant Flow Biphasic Nasal Continuous Airway Pressure (NCPAP) Versus Infant Flow NCPAP for the Facilitation of Extubation in Infants </= 1250 Grams Terminated NCT00308789 Phase 2
44 Feasibility Study of Aerosolized Surfaxin in the Prevention of Respiratory Distress Syndrome (RDS) in Premature Infants Terminated NCT00807235 Phase 2 Aerosolized lucinactant;Aerosolized lucinactant
45 Inhaled PGE1 in Neonatal Hypoxemic Respiratory Failure Withdrawn NCT00598429 Phase 2 Inhaled Prostaglandin E1
46 Early Blood Pressure Management in Extremely Premature Infants Completed NCT00874393 Phase 1 Dopamine;Hydrocortisone;Infusion Placebo;Syringe Placebo
47 Combination of Acetaminophen and Ibuprofen in the Management of Patent Ductus Arteriosus Recruiting NCT03103022 Phase 1 Acetaminophen;ibuprofen
48 S100B as a Marker of Brain Injury of Preterm Infants Unknown status NCT02082535
49 Use of Blended Oxygen for Delivery Room Resuscitation of Very Low Birth Weight Infants Unknown status NCT00369720
50 Telerehabilitation of Working Memory in Children With Periventricular Leukomalacia and Bilateral Cerebral Palsy Completed NCT02342990

Search NIH Clinical Center for Leukomalacia

Genetic Tests for Leukomalacia

Anatomical Context for Leukomalacia

MalaCards organs/tissues related to Leukomalacia:

38
Brain, Lung, Heart, Cortex, Thalamus, Pons, Endothelial

Publications for Leukomalacia

Articles related to Leukomalacia:

(show top 50) (show all 430)
# Title Authors Year
1
Neuronalinjury and roles of apoptosis and autophagy in a neonatal rat model of hypoxia-ischemia-induced periventricular leukomalacia. ( 29436652 )
2018
2
Congenital Cytomegalovirus Infection and the Occurrence of Cystic Periventricular Leukomalacia. ( 29217314 )
2018
3
Outcome of Preterm Infants with Transient Cystic Periventricular Leukomalacia on Serial Cranial Imaging Up to Term Equivalent Age. ( 29398046 )
2018
4
Upper Limb Function, Kinematic Analysis, and Dystonia Assessment in Children With Spastic Diplegic Cerebral Palsy and Periventricular Leukomalacia. ( 28776460 )
2017
5
A model of Periventricular Leukomalacia (PVL) in neonate mice with histopathological and neurodevelopmental outcomes mimicking human PVL in neonates. ( 28406931 )
2017
6
Pathophysiology of periventricular leukomalacia: What we learned from animal models. ( 29239318 )
2017
7
Association between perinatal hypoxic-ischemia and periventricular leukomalacia in preterm infants: A systematic review and meta-analysis. ( 28931047 )
2017
8
Periventricular leukomalacia with -16 DS high myopia in a 2A1 months old infant: A rare case presentation. ( 29118507 )
2017
9
Neuroprotective effects of human umbilical cord-derived mesenchymal stem cells on periventricular leukomalacia-like brain injury in neonatal rats. ( 29259700 )
2017
10
Intranasal surfactant protein D as neuroprotective rescue in a neonatal rat model of periventricular leukomalacia. ( 27109442 )
2016
11
Quality of Life of Children with Cystic Periventricular Leukomalacia - A Prospective Analysis with the Child Health Questionnaire-Parent Form 50. ( 27242979 )
2016
12
The association between pro- and anti-inflammatory cytokine polymorphisms and periventricular leukomalacia in newborns with hypoxic-ischemic encephalopathy. ( 27217792 )
2016
13
Periventricular leukomalacia in a neonatal calf. ( 27010465 )
2016
14
The vulnerability of thalamocortical circuitry to hypoxic-ischemic injury in a mouse model of periventricular leukomalacia. ( 26733225 )
2016
15
Isolated Cystic Periventricular Leukomalacia Differs from Cystic Periventricular Leukomalacia with Intraventricular Hemorrhage in Prevalence, Risk Factors and Outcomes in Preterm Infants. ( 27643988 )
2016
16
Slow pupillary light responses in infants at high risk of cerebral palsy were associated with periventricular leukomalacia and neurological outcome. ( 27468114 )
2016
17
Diffusion-Weighted Imaging of Periventricular Leukomalacia in Very Young Children: Assessment of Peritrigonal Stripe of Restricted Diffusion. ( 28030870 )
2016
18
Relation between prognosis and changes of MBP and S100B in premature infants with periventricular leukomalacia. ( 25966206 )
2015
19
Corticospinal Tract Injury Precedes Thalamic Volume Reduction in Preterm Infants with Cystic Periventricular Leukomalacia. ( 26054943 )
2015
20
Two important factors affecting the transition to breastfeeding in preterm infants: corrected age and periventricular leukomalacia. ( 26265900 )
2015
21
The whole spectrum of cystic periventricular leukomalacia of the preterm infant: results from a large consecutive case series. ( 26099229 )
2015
22
Relationship between white matter integrity and severity of motor impairment in children with cerebral palsy caused by periventricular leukomalacia. ( 26531639 )
2015
23
Scoring system for periventricular leukomalacia in infants with congenital heart disease. ( 25996891 )
2015
24
Bioinformatics analyses combined microarray identify the differentially expressed microRNAs in periventricular leukomalacia. ( 26812286 )
2015
25
Antenatal exposure to indomethacin increases the risk of severe intraventricular hemorrhage, necrotizing enterocolitis, and periventricular leukomalacia: a systematic review with metaanalysis. ( 25448524 )
2015
26
Impact of risk factors other than prematurity on periventricular leukomalacia. A population-based matched case control study. ( 25748489 )
2015
27
Chloride cotransporter NKCC1 inhibitor bumetanide protects against white matter injury in a rodent model of periventricular leukomalacia. ( 25585037 )
2015
28
The Effects of the Severity of Periventricular Leukomalacia on the Neuropsychological Outcomes of Preterm Children. ( 26385973 )
2015
29
Increased fetal heart rate variability in periventricular leukomalacia. ( 26338690 )
2015
30
Screening Cranial Imaging at Multiple Time Points Improves Cystic Periventricular Leukomalacia Detection. ( 25730135 )
2015
31
Clinical study of cerebral palsy in 408 children with periventricular leukomalacia. ( 25780432 )
2015
32
Latency after preterm prelabor rupture of the membranes: increased risk for periventricular leukomalacia. ( 25136457 )
2014
33
Retinal vessel pathologies in a rat model of periventricular leukomalacia: a new model for retinopathy of prematurity? ( 25698709 )
2014
34
Visual Evoked Potentials in Infants with Diffuse Periventricular Leukomalacia. ( 24615931 )
2014
35
Severe cystic periventricular leukomalacia in a premature infant with capnocytophaga sepsis. ( 25452885 )
2014
36
Diffusion tensor imaging-demonstrated differences between hemiplegic and diplegic cerebral palsy with symmetric periventricular leukomalacia. ( 22976239 )
2013
37
Using the Alberta Infant Motor Scale to early identify very low-birth-weight infants with cystic periventricular leukomalacia. ( 21959127 )
2013
38
Epileptic Encephalopathy With Continuous Spike and Wave During Sleep Associated to Periventricular Leukomalacia. ( 24293309 )
2013
39
Texture analysis of periventricular echogenicity on neonatal cranial ultrasound predicts periventricular leukomalacia. ( 24246513 )
2013
40
Risk factors for preoperative periventricular leukomalacia in term neonates with hypoplastic left heart syndrome are patient related. ( 23879933 )
2013
41
Differences between periventricular hemorrhagic infarction and periventricular leukomalacia. ( 23978489 )
2013
42
Ischemia-induced neuroinflammation is associated with disrupted development of oligodendrocyte progenitors in a model of periventricular leukomalacia. ( 23445614 )
2013
43
Spontaneous movements in the supine position of healthy term infants and preterm infants with or without periventricular leukomalacia. ( 22656321 )
2013
44
Neurodevelopmental outcomes of children with periventricular leukomalacia. ( 23727042 )
2013
45
Visuospatial working memory in toddlers with a history of periventricular Leukomalacia: an EEG narrow-band power analysis. ( 23922816 )
2013
46
12/15-lipoxygenase expression is increased in oligodendrocytes and microglia of periventricular leukomalacia. ( 23838566 )
2013
47
Preterm twin and triplet pregnancies are at increased risk for the development of cystic periventricular leukomalacia. ( 22795624 )
2013
48
Periventricular leukomalacia and less invasive surfactant administration in extremely preterm infants. Concerning the article by k. Klebermass-schrehof et Al.: less invasive surfactant administration in extremely preterm infants: impact on mortality and morbidity [neonatology 2013;103:252-258]. ( 23817316 )
2013
49
Diphenyleneiodonium protects preoligodendrocytes against endotoxin-activated microglial NADPH oxidase-generated peroxynitrite in a neonatal rat model of periventricular leukomalacia. ( 23174417 )
2013
50
Epilepsy in children with periventricular leukomalacia. ( 23891141 )
2013

Variations for Leukomalacia

Expression for Leukomalacia

Search GEO for disease gene expression data for Leukomalacia.

Pathways for Leukomalacia

Pathways related to Leukomalacia according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.29 ALOX15 IL18 IL18R1 IL1R1 IL6 NOS2
2
Show member pathways
12.87 IL18 IL18R1 IL1R1 IL6 NOS2 TNF
3
Show member pathways
12.46 IL18 IL18R1 IL1R1 IL6 TNF
4
Show member pathways
12.45 IL6 NOS2 SPP1 TNF
5
Show member pathways
12.44 IL18 IL18R1 IL6 NOS2 TNF
6
Show member pathways
12.18 IL1R1 IL6 NOS2 TNF
7 12.15 IL18 IL6 NOS2 TNF
8
Show member pathways
12.07 IL1R1 IL6 NOS2 TNF
9 11.86 IL18R1 IL6 TNF
10
Show member pathways
11.79 IL18 IL18R1 IL1R1 NOS2
11 11.78 IL18 IL6 TNF
12 11.75 IL18 IL6 NOS2
13 11.72 IL18 IL1R1 TNF
14
Show member pathways
11.72 IL18 IL18R1 IL6 TNF
15 11.68 IL6 NOS2 TNF
16 11.67 EPO IL6 NOS2 PDHA1
17 11.62 IL6 NOS2 TNF
18 11.61 EPO IL1R1 IL6 TNF
19 11.59 IL6 SPP1 TNF
20
Show member pathways
11.59 IL6 NOS2 TNF
21 11.54 IL1R1 IL6 NOS2 TNF
22 11.51 IL18 IL6 TNF
23 11.44 IL18 IL6 TNF
24 11.43 IL1R1 IL6 MBP NOS2 TNF
25 11.42 IL18 NOS2 TNF
26 11.37 IL6 SPP1 TNF
27 11.24 EPO NOS2 PDHA1
28 11.2 IL18 IL6 TNF
29 11.15 IL18 IL1R1 IL6 TNF
30 11.14 IL18 IL6 TNF
31 11.08 ALOX15 IL18 IL6 NOS2 TNF
32 10.45 CHKA PDHA1

GO Terms for Leukomalacia

Biological processes related to Leukomalacia according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.77 ALOX15 IL18 IL6 SPP1 TNF
2 immune response GO:0006955 9.63 IL18 IL18R1 IL1R1 IL6 MBP TNF
3 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.61 EPO IL18 IL6
4 positive regulation of smooth muscle cell proliferation GO:0048661 9.58 IL18 IL6 TNF
5 phosphatidylethanolamine biosynthetic process GO:0006646 9.51 ALOX15 CHKA
6 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.49 ALOX15 TNF
7 negative regulation of lipid storage GO:0010888 9.48 IL6 TNF
8 response to salt stress GO:0009651 9.46 EPO TNF
9 positive regulation of interferon-gamma production GO:0032729 9.43 IL18 IL18R1 TNF
10 interleukin-18-mediated signaling pathway GO:0035655 9.32 IL18 IL18R1
11 positive regulation of NF-kappaB import into nucleus GO:0042346 9.13 IL18 IL18R1 TNF
12 regulation of receptor activity GO:0010469 9.1 EPO IL18 IL6 NPPB SPP1 TNF

Molecular functions related to Leukomalacia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.33 IL1R1 MBP TNF
2 cytokine activity GO:0005125 9.02 EPO IL18 IL6 SPP1 TNF
3 interleukin-1 receptor activity GO:0004908 8.96 IL18R1 IL1R1

Sources for Leukomalacia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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