MCID: LKM006
MIFTS: 43

Leukomalacia malady

Categories: Rare diseases

Aliases & Classifications for Leukomalacia

Aliases & Descriptions for Leukomalacia:

Name: Leukomalacia 50

Classifications:



Summaries for Leukomalacia

MalaCards based summary : Leukomalacia is related to periventricular leukomalacia and cerebritis. An important gene associated with Leukomalacia is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Toll-Like receptor Signaling Pathways. The drugs Dopamine and Levodopa have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and cortex, and related phenotypes are homeostasis/metabolism and cellular

Related Diseases for Leukomalacia

Diseases related to Leukomalacia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
id Related Disease Score Top Affiliating Genes
1 periventricular leukomalacia 12.5
2 cerebritis 10.3
3 vps11-related autosomal recessive hypomyelinating leukodystrophy 10.3 IL6 TNF
4 unilateral multicystic dysplastic kidney 10.3 IL6 NPPB TNF
5 joint disorders 10.3 IL6 NPPB TNF
6 trichomalacia 10.2 IL6 MBP TNF
7 gastric dilatation 10.2 IL6 MBP TNF
8 vitamin a embryopathy 10.2 EPO IL6
9 pancreas lymphoma 10.2 IL6 NPPB TNF
10 bladder signet ring cell adenocarcinoma 10.2 IL6 MBP TNF
11 niemann-pick disease 10.2 IL6 MBP SLC1A2
12 dyslexia 5 10.2 IL6 TNF
13 hyperostosis 10.2 IL6 MBP MYT1
14 ectodermal dysplasia bartalos type 10.2 IL6 NOS2 TNF
15 steroid dehydrogenase deficiency dental anomalies 10.2 IL18 IL6 TNF
16 orthostatic proteinuria 10.2 IL18 IL6 TNF
17 red cell phospholipid defect with hemolysis 10.2 IL18 IL6 TNF
18 diabetic encephalopathy 10.2 IL6 NPPB TNF
19 cerebral palsy 10.2
20 breast reconstruction 10.1 EPO IL6 MBP
21 primary ciliary dyskinesia 10.1 IL1R1 IL6 TNF
22 anterior foramen magnum meningioma 10.1 EPO IL6 TNF
23 splenic marginal zone lymphoma 10.1 IL6 NOS2 TNF
24 pyelonephritis 10.1 NOS2 NPPB TNF
25 detrusor sphincter dyssynergia 10.1 IL6 NOS2 NPPB TNF
26 familial nephrotic syndrome 10.1 EPO IL6 TNF
27 keratomalacia 10.1 IL6 NOS2 TNF
28 eye carcinoma in situ 10.1 IL18 IL18R1 TNF
29 tau syndrome 10.1 IL18 TNF
30 migraine with aura 10.1 IL6 SLC17A5 TNF
31 hereditary alpha tryptasemia syndrome 10.1 IL6 SLC17A5 TNF
32 neonatal jaundice 10.1 IL18 IL6 MBP TNF
33 paranasal sinus sarcoma 10.1 IL6 SLC17A5 TNF
34 amelogenesis imperfecta 10.1 IL6 SLC17A5 TNF
35 substance-induced psychosis 10.1 IL6 MBP NOS2 TNF
36 keratoconus 10.0 IL18R1 IL1R1 IL6 TNF
37 synovium cancer 10.0 IL18 IL6 TNF
38 congenital hypoplastic anemia 10.0 IL6 SLC17A5 SLC1A2 TNF
39 acquired thrombocytopenia 10.0 IL18 IL6 NOS2 TNF
40 pulpitis 10.0 NOS2 SLC17A5 TNF
41 laryngotracheoesophageal cleft type 2 10.0 IL18 IL6 SLC17A5
42 neuronitis 10.0
43 microscopic breast papilloma 10.0 NOS2 NPPB TNF
44 hyperuricemia, pulmonary hypertension, renal failure, and alkalosis 10.0 IL6 NPPB TNF
45 advanced sleep phase syndrome, familial, 1 10.0 IL6 MBP NOS2 SPP1 TNF
46 benign neonatal seizures 10.0 IL18 IL1R1 IL6 TNF
47 intracranial hemorrhage in brain cerebrovascular malformations 10.0 IL18 IL1R1 IL6 TNF
48 spasticity 9.9
49 epilepsy 9.9
50 cerebral visual impairment 9.9

Graphical network of the top 20 diseases related to Leukomalacia:



Diseases related to Leukomalacia

Symptoms & Phenotypes for Leukomalacia

MGI Mouse Phenotypes related to Leukomalacia:

44 (show all 16)
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.35 IL6 MBP MYT1 NOS2 PDHA1 SLC17A5
2 cellular MP:0005384 10.3 ALOX15 EPO GRM1 IL18 IL1R1 IL6
3 growth/size/body region MP:0005378 10.29 ALOX15 GRM1 IL18 IL1R1 IL6 MBP
4 behavior/neurological MP:0005386 10.25 SLC17A5 SLC1A2 SPP1 TNF GRM1 IL18
5 mortality/aging MP:0010768 10.24 PDHA1 SLC17A5 SLC1A2 SPP1 TNF ALOX15
6 cardiovascular system MP:0005385 10.19 ALOX15 EPO IL18 IL1R1 IL6 NOS2
7 hematopoietic system MP:0005397 10.19 MBP NOS2 SPP1 TNF IL6 ALOX15
8 immune system MP:0005387 10.16 IL18 IL18R1 IL1R1 IL6 MBP NOS2
9 integument MP:0010771 10.09 IL1R1 IL6 NOS2 SPP1 TNF ALOX15
10 adipose tissue MP:0005375 10.03 GRM1 IL18 IL1R1 IL6 NOS2 TNF
11 muscle MP:0005369 10.02 EPO GRM1 IL18 IL1R1 IL6 MYT1
12 liver/biliary system MP:0005370 9.95 CHKA EPO IL1R1 IL6 NOS2 SPP1
13 nervous system MP:0003631 9.9 IL1R1 IL6 MBP NOS2 PDHA1 SLC17A5
14 neoplasm MP:0002006 9.8 ALOX15 GRM1 IL1R1 IL6 NOS2 SPP1
15 reproductive system MP:0005389 9.56 ALOX15 GRM1 IL6 MBP NOS2 PDHA1
16 vision/eye MP:0005391 9.23 GRM1 IL18 IL1R1 IL6 MBP NOS2

Drugs & Therapeutics for Leukomalacia

Drugs for Leukomalacia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 139)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 3,Phase 1 51-61-6, 62-31-7 681
2
Levodopa Approved Phase 4 59-92-7 6047
3
Magnesium Sulfate Approved, Vet_approved Phase 4,Phase 3 7487-88-9 24083
4
Progesterone Approved, Vet_approved Phase 4,Phase 2,Phase 3 57-83-0 5994
5
Ibuprofen Approved Phase 4,Phase 3,Phase 2,Phase 1 15687-27-1 3672
6
Indomethacin Approved, Investigational Phase 4,Phase 1,Phase 2 53-86-1 3715
7 Poractant alfa Approved Phase 4 129069-19-8
8 Analgesics Phase 4,Phase 3,Phase 1,Phase 2
9 calcium channel blockers Phase 4,Phase 3
10 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1
11 Tocolytic Agents Phase 4,Phase 3,Phase 1,Phase 2
12 Anesthetics Phase 4,Phase 3
13 Dihydroxyphenylalanine Phase 4
14 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
15 Dopamine Agents Phase 4,Phase 3,Phase 1
16 Anti-Arrhythmia Agents Phase 4,Phase 3
17 Anticonvulsants Phase 4,Phase 3
18 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1
19 Pulmonary Surfactants Phase 4,Phase 3,Phase 2
20 Respiratory System Agents Phase 4,Phase 3,Phase 2
21 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1
22 Carbidopa, levodopa drug combination Phase 4
23 Calcium, Dietary Phase 4,Phase 3,Phase 2
24 Central Nervous System Depressants Phase 4,Phase 3
25 Progestins Phase 4,Phase 2,Phase 3
26 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 1,Phase 2
27 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 1,Phase 2
28 Hormone Antagonists Phase 4,Phase 2,Phase 3
29 Hormones Phase 4,Phase 2,Phase 3
30 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3
31 Estrogen Antagonists Phase 4,Phase 2,Phase 3
32 Estrogens Phase 4,Phase 2,Phase 3
33 11-hydroxyprogesterone Phase 4,Phase 2,Phase 3
34 17-alpha-hydroxy-progesterone caproate Phase 4,Phase 2,Phase 3
35 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 1,Phase 2
36 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 1,Phase 2
37 Antirheumatic Agents Phase 4,Phase 3,Phase 1,Phase 2
38 Caproate Nutraceutical Phase 4,Phase 2,Phase 3
39
Heparin Approved, Investigational Phase 3 9005-49-6 772 46507594
40
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
41
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
42
Phenobarbital Approved Phase 3 50-06-6 4763
43
Fluconazole Approved Phase 3 86386-73-4 3365
44
Betamethasone Approved, Vet_approved Phase 3 378-44-9 9782
45
Pentoxifylline Approved, Investigational Phase 3 6493-05-6 4740
46
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
47
Benzocaine Approved Phase 2, Phase 3 1994-09-7, 94-09-7 2337
48
Dalteparin Approved Phase 3 9041-08-1
49 Simethicone Approved Phase 3
50
Nitric Oxide Approved Phase 2, Phase 3 10102-43-9 145068

Interventional clinical trials:

(show top 50) (show all 74)
id Name Status NCT ID Phase
1 Dopamine Treatment in Children With Cerebral Palsy With Dystonia- A Double Blind Controlled Study Unknown status NCT01361373 Phase 4
2 Neuroprotection by Magnesium Sulfate Given to Women at Risk of Very Preterm Birth Completed NCT00120588 Phase 4
3 Efficacy of 17 Alpha-hydroxyprogesterones Caproate for the Prevention of Preterm Delivery Completed NCT00331695 Phase 4
4 OPTIMIST-A Trial: Minimally-invasive Surfactant Therapy in Preterm Infants 25-28 Weeks Gestation on CPAP Recruiting NCT02140580 Phase 4
5 Comparing Ibuprofen And Indomethacin For The Treatment Of The Patent Ductus Arteriosus in Very Premature Babies Withdrawn NCT00470743 Phase 4
6 Magnesium Sulfate to Prevent Brain Injury in Premature Infants Unknown status NCT00065949 Phase 3
7 Premature Infants in Need of Transfusion (PINT) Completed NCT00182390 Phase 3
8 Antenatal Phenobarbital to Prevent Neonatal Intracranial Hemorrhage Completed NCT00009620 Phase 3
9 Beneficial Effects of Antenatal Magnesium Sulfate (BEAM Trial) Completed NCT00014989 Phase 3
10 17OHP for Reduction of Neonatal Morbidity Due to Preterm Birth (PTB) in Twin and Triplet Pregnancies Completed NCT00163020 Phase 2, Phase 3
11 Fluconazole Prophylaxis for the Prevention of Candidiasis in Infants Less Than 750 Grams Birthweight Completed NCT00734539 Phase 3
12 NIV Strategies for RDS in Preterm Infants. NIV (Non Invasive Ventilation), RDS (Respiratory Distress Syndrome) Completed NCT02259400 Phase 2, Phase 3
13 Caffeine for Apnea of Prematurity (CAP) Completed NCT00182312 Phase 3
14 Pentoxifylline and Late Onset Sepsis in Preterm Infants Completed NCT02163174 Phase 3
15 High Versus Low Dose of Caffeine for Apnea of Prematurity Completed NCT02103777 Phase 3
16 Safety and Efficacy Study of Ibuprofen l-Lysine Solution in Premature Infants for Treatment of PDA Completed NCT00440804 Phase 3
17 Omega-3 Fatty Acid Supplementation to Prevent Preterm Birth in High Risk Pregnancies Completed NCT00135902 Phase 3
18 Trial of Aggressive Versus Conservative Phototherapy in Infants <1,000 Grams Birth Weight Completed NCT00114543 Phase 3
19 Trial of Progesterone in Twins and Triplets to Prevent Preterm Birth (STTARS) Completed NCT00099164 Phase 3
20 Prevention of Maternal and Perinatal Complications by Enoxaparin in Women With Previous Severe Preeclampsia Completed NCT00986765 Phase 3
21 Management of Hypotension In the Preterm Infant Recruiting NCT01482559 Phase 3
22 Maternal Omega-3 Supplementation to Reduce Bronchopulmonary Dysplasia Recruiting NCT02371460 Phase 3
23 Dose Reduction of Antenatal Betamethasone Given to Prevent the Neonatal Complications Associated With Very Preterm Birth Recruiting NCT02897076 Phase 3
24 Tracheal Occlusion To Accelerate Lung Growth (TOTAL) Trial for Severe Pulmonary Hypoplasia Recruiting NCT01240057 Phase 2, Phase 3
25 Inhaled Nitric Oxide and Neuroprotection in Premature Infants Active, not recruiting NCT00515281 Phase 2, Phase 3
26 Surfactant Positive Airway Pressure and Pulse Oximetry Trial Active, not recruiting NCT00233324 Phase 3
27 Effect of Erythropoietin in Premature Infants on White Matter Lesions and Neurodevelopmental Outcome Not yet recruiting NCT03110341 Phase 3
28 Efficacy and Safety of Goat Lung Surfactant for the Treatment of Respiratory Distress Syndrome in Preterm Neonates Not yet recruiting NCT02774044 Phase 2, Phase 3
29 Probiotics for the Prevention of Premature Birth and Neonatal Related Morbidity Terminated NCT00303082 Phase 3
30 Minimal Breathing Support and Early Steroids to Prevent Chronic Lung Disease in Extremely Premature Infants (SAVE) Terminated NCT00005777 Phase 3
31 Recombinant Erythropoietin for Neuroprotection in Very Preterm Infants Unknown status NCT00910234 Phase 1, Phase 2
32 Minimally Invasive Surfactant Therapy Followed by CPAP (MISTCPAP) in Preterm Infants With RDS Unknown status NCT01723683 Phase 2
33 Does Erythropoietin Improve Outcome in Very Preterm Infants? Completed NCT00413946 Phase 2
34 High-frequency Oscillatory Ventilation (HFOV) in Preterm Infants With Severe Respiratory Distress Syndrome (RDS) Completed NCT01496508 Phase 2
35 Effects of Delayed Cord Clamp and/or Indomethacin on Preterm Infant Brain Injury Recruiting NCT02221219 Phase 1, Phase 2
36 Randomized Trial of Maternal Progesterone Therapy Recruiting NCT02133573 Phase 2
37 The Synergistic Pharmacologic Intervention for Prevention of ROP (SPIPROP Study) Recruiting NCT02344225 Phase 2
38 'TOTAL' (Tracheal Occlusion To Accelerate Lung Growth) Trial Recruiting NCT02875860 Phase 2
39 Probiotics Reduce Incidence of Necrotizing Enterocolitis for Very Low Birth Weight Infants Terminated NCT00540033 Phase 2
40 High-Dose Erythropoietin in Extremely Premature Infants to Prevent/Attenuate Brain Injury: A Phase II Study Terminated NCT00589953 Phase 2
41 A Trial of Infant Flow Biphasic Nasal Continuous Airway Pressure (NCPAP) Versus Infant Flow NCPAP for the Facilitation of Extubation in Infants </= 1250 Grams Terminated NCT00308789 Phase 2
42 Feasibility Study of Aerosolized Surfaxin in the Prevention of Respiratory Distress Syndrome (RDS) in Premature Infants Terminated NCT00807235 Phase 2
43 Inhaled PGE1 in Neonatal Hypoxemic Respiratory Failure Withdrawn NCT00598429 Phase 2
44 Early Blood Pressure Management in Extremely Premature Infants Completed NCT00874393 Phase 1
45 Combination of Acetaminophen and Ibuprofen in the Management of Patent Ductus Arteriosus Recruiting NCT03103022 Phase 1
46 S100B as a Marker of Brain Injury of Preterm Infants Unknown status NCT02082535
47 Use of Blended Oxygen for Delivery Room Resuscitation of Very Low Birth Weight Infants Unknown status NCT00369720
48 Telerehabilitation of Working Memory in Children With Periventricular Leukomalacia and Bilateral Cerebral Palsy Completed NCT02342990
49 Umbilical Cord Blood Proteomic Analysis and Neonatal Brain Injury Completed NCT00375908
50 Liberal Versus Restrictive Transfusion Guidelines for Preterm Infants Completed NCT00369005

Search NIH Clinical Center for Leukomalacia

Genetic Tests for Leukomalacia

Anatomical Context for Leukomalacia

MalaCards organs/tissues related to Leukomalacia:

39
Brain, Heart, Cortex, Endothelial, Placenta, Thalamus, Pons

Publications for Leukomalacia

Articles related to Leukomalacia:

(show top 50) (show all 420)
id Title Authors Year
1
Quality of Life of Children with Cystic Periventricular Leukomalacia - A Prospective Analysis with the Child Health Questionnaire-Parent Form 50. ( 27242979 )
2016
2
The vulnerability of thalamocortical circuitry to hypoxic-ischemic injury in a mouse model of periventricular leukomalacia. ( 26733225 )
2016
3
Diffusion-Weighted Imaging of Periventricular Leukomalacia in Very Young Children: Assessment of Peritrigonal Stripe of Restricted Diffusion. ( 28030870 )
2016
4
Slow pupillary light responses in infants at high risk of cerebral palsy were associated with periventricular leukomalacia and neurological outcome. ( 27468114 )
2016
5
Isolated Cystic Periventricular Leukomalacia Differs from Cystic Periventricular Leukomalacia with Intraventricular Hemorrhage in Prevalence, Risk Factors and Outcomes in Preterm Infants. ( 27643988 )
2016
6
The association between pro- and anti-inflammatory cytokine polymorphisms and periventricular leukomalacia in newborns with hypoxic-ischemic encephalopathy. ( 27217792 )
2016
7
Intranasal surfactant protein D as neuroprotective rescue in a neonatal rat model of periventricular leukomalacia. ( 27109442 )
2016
8
Periventricular leukomalacia in a neonatal calf. ( 27010465 )
2016
9
Two important factors affecting the transition to breastfeeding in preterm infants: corrected age and periventricular leukomalacia. ( 26265900 )
2015
10
Corticospinal Tract Injury Precedes Thalamic Volume Reduction in Preterm Infants with Cystic Periventricular Leukomalacia. ( 26054943 )
2015
11
Clinical study of cerebral palsy in 408 children with periventricular leukomalacia. ( 25780432 )
2015
12
Scoring system for periventricular leukomalacia in infants with congenital heart disease. ( 25996891 )
2015
13
Screening Cranial Imaging at Multiple Time Points Improves Cystic Periventricular Leukomalacia Detection. ( 25730135 )
2015
14
The whole spectrum of cystic periventricular leukomalacia of the preterm infant: results from a large consecutive case series. ( 26099229 )
2015
15
Relationship between white matter integrity and severity of motor impairment in children with cerebral palsy caused by periventricular leukomalacia. ( 26531639 )
2015
16
The Effects of the Severity of Periventricular Leukomalacia on the Neuropsychological Outcomes of Preterm Children. ( 26385973 )
2015
17
Impact of risk factors other than prematurity on periventricular leukomalacia. A population-based matched case control study. ( 25748489 )
2015
18
Chloride cotransporter NKCC1 inhibitor bumetanide protects against white matter injury in a rodent model of periventricular leukomalacia. ( 25585037 )
2015
19
Antenatal exposure to indomethacin increases the risk of severe intraventricular hemorrhage, necrotizing enterocolitis, and periventricular leukomalacia: a systematic review with metaanalysis. ( 25448524 )
2015
20
Increased fetal heart rate variability in periventricular leukomalacia. ( 26338690 )
2015
21
Bioinformatics analyses combined microarray identify the differentially expressed microRNAs in periventricular leukomalacia. ( 26812286 )
2015
22
Relation between prognosis and changes of MBP and S100B in premature infants with periventricular leukomalacia. ( 25966206 )
2015
23
Latency after preterm prelabor rupture of the membranes: increased risk for periventricular leukomalacia. ( 25136457 )
2014
24
Visual Evoked Potentials in Infants with Diffuse Periventricular Leukomalacia. ( 24615931 )
2014
25
Severe cystic periventricular leukomalacia in a premature infant with capnocytophaga sepsis. ( 25452885 )
2014
26
Retinal vessel pathologies in a rat model of periventricular leukomalacia: a new model for retinopathy of prematurity? ( 25698709 )
2014
27
Texture analysis of periventricular echogenicity on neonatal cranial ultrasound predicts periventricular leukomalacia. ( 24246513 )
2013
28
The expression profile of microRNAs in wistar rats with lipopolysaccharide-induced periventricular leukomalacia. ( 23354881 )
2013
29
Periventricular leukomalacia and less invasive surfactant administration in extremely preterm infants. Concerning the article by k. Klebermass-schrehof et Al.: less invasive surfactant administration in extremely preterm infants: impact on mortality and morbidity [neonatology 2013;103:252-258]. ( 23817316 )
2013
30
Potential of diffusion tensor MR imaging in the assessment of cognitive impairments in children with periventricular leukomalacia born preterm. ( 23084875 )
2013
31
Diphenyleneiodonium protects preoligodendrocytes against endotoxin-activated microglial NADPH oxidase-generated peroxynitrite in a neonatal rat model of periventricular leukomalacia. ( 23174417 )
2013
32
White matter loss in a mouse model of periventricular leukomalacia is rescued by trophic factors. ( 24961618 )
2013
33
Risk factors for preoperative periventricular leukomalacia in term neonates with hypoplastic left heart syndrome are patient related. ( 23879933 )
2013
34
Neurodevelopmental outcomes of children with periventricular leukomalacia. ( 23727042 )
2013
35
Amplitude-integrated electroencephalogram 1 h after birth in a preterm infant with cystic periventricular leukomalacia. ( 22196997 )
2013
36
12/15-lipoxygenase expression is increased in oligodendrocytes and microglia of periventricular leukomalacia. ( 23838566 )
2013
37
Epilepsy in children with periventricular leukomalacia. ( 23891141 )
2013
38
Discovering hidden relationships in physiological signals for prediction of Periventricular Leukomalacia. ( 24111376 )
2013
39
Diffusion tensor imaging-demonstrated differences between hemiplegic and diplegic cerebral palsy with symmetric periventricular leukomalacia. ( 22976239 )
2013
40
Prediction of Periventricular Leukomalacia Occurrence in Neonates After Heart Surgery. ( 24122606 )
2013
41
Visuospatial working memory in toddlers with a history of periventricular Leukomalacia: an EEG narrow-band power analysis. ( 23922816 )
2013
42
Spontaneous movements in the supine position of healthy term infants and preterm infants with or without periventricular leukomalacia. ( 22656321 )
2013
43
Ischemia-induced neuroinflammation is associated with disrupted development of oligodendrocyte progenitors in a model of periventricular leukomalacia. ( 23445614 )
2013
44
Differences between periventricular hemorrhagic infarction and periventricular leukomalacia. ( 23978489 )
2013
45
Epileptic Encephalopathy With Continuous Spike and Wave During Sleep Associated to Periventricular Leukomalacia. ( 24293309 )
2013
46
Preterm twin and triplet pregnancies are at increased risk for the development of cystic periventricular leukomalacia. ( 22795624 )
2013
47
Using the Alberta Infant Motor Scale to early identify very low-birth-weight infants with cystic periventricular leukomalacia. ( 21959127 )
2013
48
Neuroprotective effect of neotrofin in a neonatal rat model of periventricular leukomalacia. ( 22579826 )
2012
49
Application of decision tree in the prediction of periventricular leukomalacia (PVL) occurrence in neonates after heart surgery. ( 23367279 )
2012
50
Risk factors for isolated periventricular leukomalacia. ( 22353288 )
2012

Variations for Leukomalacia

Expression for Leukomalacia

Search GEO for disease gene expression data for Leukomalacia.

Pathways for Leukomalacia

Pathways related to Leukomalacia according to GeneCards Suite gene sharing:

(show all 31)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.29 ALOX15 IL18 IL18R1 IL1R1 IL6 NOS2
2
Show member pathways
12.9 IL18 IL18R1 IL1R1 IL6 NOS2 TNF
3
Show member pathways
12.46 IL18 IL18R1 IL1R1 IL6 TNF
4
Show member pathways
12.44 IL18 IL18R1 IL6 NOS2 TNF
5
Show member pathways
12.17 IL1R1 IL6 NOS2 TNF
6 12.15 IL18 IL6 NOS2 TNF
7
Show member pathways
12.08 IL1R1 IL6 NOS2 TNF
8 11.86 IL18R1 IL6 TNF
9
Show member pathways
11.79 IL18 IL18R1 IL1R1 NOS2
10 11.78 IL18 IL6 TNF
11 11.75 IL18 IL6 NOS2
12
Show member pathways
11.73 IL18 IL18R1 IL6 TNF
13 11.72 IL18 IL1R1 TNF
14 11.68 IL6 NOS2 TNF
15 11.66 EPO IL6 NOS2 PDHA1
16 11.64 IL6 NOS2 TNF
17 11.61 EPO IL1R1 IL6 TNF
18 11.59 IL6 SPP1 TNF
19
Show member pathways
11.59 IL6 NOS2 TNF
20 11.54 IL1R1 IL6 NOS2 TNF
21 11.51 IL18 IL6 TNF
22 11.43 IL18 IL6 TNF
23 11.43 IL1R1 IL6 MBP NOS2 TNF
24 11.4 IL18 NOS2 TNF
25 11.37 IL6 SPP1 TNF
26 11.24 EPO NOS2 PDHA1
27 11.2 IL18 IL6 TNF
28 11.15 IL18 IL1R1 IL6 TNF
29 11.14 IL18 IL6 TNF
30 11.08 ALOX15 IL18 IL6 NOS2 TNF
31 10.45 CHKA PDHA1

GO Terms for Leukomalacia

Biological processes related to Leukomalacia according to GeneCards Suite gene sharing:

(show all 16)
id Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.77 ALOX15 IL18 IL6 SPP1 TNF
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.73 ALOX15 EPO IL6 TNF
3 positive regulation of protein kinase B signaling GO:0051897 9.7 IL18 IL6 TNF
4 positive regulation of smooth muscle cell proliferation GO:0048661 9.63 IL18 IL6 TNF
5 positive regulation of chemokine production GO:0032722 9.56 IL6 TNF
6 phosphatidylethanolamine biosynthetic process GO:0006646 9.55 ALOX15 CHKA
7 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.54 ALOX15 TNF
8 negative regulation of lipid storage GO:0010888 9.51 IL6 TNF
9 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.5 EPO IL18 IL6
10 response to salt stress GO:0009651 9.49 EPO TNF
11 positive regulation of T-helper 2 cell differentiation GO:0045630 9.48 IL18 IL6
12 positive regulation of interferon-gamma production GO:0032729 9.43 IL18 IL18R1 TNF
13 immune response GO:0006955 9.43 IL18 IL18R1 IL1R1 IL6 MBP TNF
14 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.4 IL6 TNF
15 interleukin-18-mediated signaling pathway GO:0035655 9.16 IL18 IL18R1
16 positive regulation of NF-kappaB import into nucleus GO:0042346 8.8 IL18 IL18R1 TNF

Molecular functions related to Leukomalacia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.33 IL1R1 MBP TNF
2 cytokine activity GO:0005125 9.26 IL18 IL6 SPP1 TNF
3 interleukin-1 receptor activity GO:0004908 8.62 IL18R1 IL1R1

Sources for Leukomalacia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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