MCID: LKM006
MIFTS: 35

Leukomalacia malady

Summaries for Leukomalacia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Periventricular leukomalacia (PVL) is a form of white-matter brain injury, characterized by the necrosis... more...

MalaCards: Leukomalacia is related to periventricular leukomalacia and cerebral palsy. An important gene associated with Leukomalacia is MYT1 (myelin transcription factor 1), and among its related pathways are PEDF Induced Signaling and TGF-Beta Pathway. The compounds cycloheximide and estrogen have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotypes are renal/urinary system and vision/eye.

Aliases & Classifications for Leukomalacia

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42NIH Rare Diseases
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Aliases & Descriptions:

leukomalacia 42


Related Diseases for Leukomalacia

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17GeneCards, 18GeneDecks
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Diseases related to Leukomalacia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 222)
idRelated DiseaseScoreTop Affiliating Genes
1periventricular leukomalacia31.8MYT1, APP, NES
2cerebral palsy30.6CPVL
3schizophrenia30.1GRM1, MBP, IL18R1, SLC1A2
4ischemia30.1NES, NPPB, VEGFA, SLC1A2, NOS2
5hypertension29.9NPPB
6retinopathy of prematurity29.9CPVL, VEGFA
7asthma29.8IL18R1, MBP, IL18, NOS2, IL1B
8cerebritis10.7
9neuronitis10.4
10spastic diplegia10.2
11west syndrome10.2
12strabismus10.1
13parkinson's disease10.0NES
14malaria10.0IL18R1
15stroke, ischemic10.0NES
16cerebrovascular disease10.0APP
17herpes simplex10.0IL18R1
18pheochromocytoma10.0APP
19hepatitis10.0IL18
20lupus erythematosus10.0IL18
21hydrocephalus10.0NES
22cervical cancer10.0IL1R1
23adenoma10.0NES
24adult t-cell leukemia10.0SERPINH1
25nephrotic syndrome10.0PTPRC
26leiomyoma10.0NES
27cystic fibrosis10.0IL1R1
28graves' disease10.0PTPRC
29sjogren's syndrome10.0IL18R1
30atopy10.0IL18
31myopathy10.0APP
32infertility10.0IL18R1
33biliary atresia10.0SPP1
34macroglobulinemia, waldenstrom, somatic10.0PTPRC
35funisitis10.0SERPINH1
36myocardial infarction10.0NPPB
37dermatitis10.0IL18
38essential hypertension10.0NPPB
39leiomyosarcoma10.0NES
40alopecia areata10.0IL1R1
41malignant mesothelioma10.0SPP1
42kawasaki disease10.0NPPB
43acute myocardial infarction10.0NPPB
44arteriosclerosis10.0SPP1
45gastrointestinal system disease10.0NOS2
46dilated cardiomyopathy10.0NPPB
47hyperglycemia10.0NOS2
48cerebral amyloid angiopathy10.0APP
49brain cancer10.0NES
50influenza10.0PTPRC

Graphical network of the top 20 diseases related to Leukomalacia:



Diseases related to leukomalacia

Clinical Features for Leukomalacia

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Drugs & Therapeutics for Leukomalacia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Leukomalacia

Drug clinical trials:

Search ClinicalTrials for Leukomalacia

Search NIH Clinical Center for Leukomalacia

Search CenterWatch for Leukomalacia

Genetic Tests for Leukomalacia

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Anatomical Context for Leukomalacia

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32MalaCards
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MalaCards organs/tissues related to Leukomalacia:

32
Brain

Animal Models for Leukomalacia or affiliated genes

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36MGI
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Publications for Leukomalacia

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Genetic Variations for Leukomalacia

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Expression for genes affiliated with Leukomalacia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Leukomalacia

Search GEO for disease gene expression data for Leukomalacia.

Pathways for genes affiliated with Leukomalacia

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51QIAGEN, 29KEGG, 12EMD Millipore, 52R&D Systems, 37NCBI BioSystems Database, 53Reactome
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Pathways related to Leukomalacia according to GeneCards/GeneDecks:

(show all 35)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.3IL18R1
2
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10.3IL18R1
310.3IL18
410.3IL18
510.3IL18
6
Transcription Role of VDR in regulation of genes involved in osteoporosis
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10.2SPP1
710.1IL1B
810.1IL1B
9
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10.1IL18R1, IL18
1010.0SPP1, SERPINH1
119.9IL1B, IL18
12
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9.8PTPRC, IL1R1, IL18R1
13
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9.5IL6, IL1B, IL1R1
149.5IL6, IL1B, IL18
159.5IL6, IL18, IL1B
169.5VEGFA, MYT1, IL1R1, APP
17
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9.5IL18, IL1B, IL18R1, IL1R1
189.5NOS2, IL6, IL1B
199.4EPO, VEGFA, NOS2
20
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9.4IL18, APP, IL6, IL1B
21
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9.3IL18, IL1B, IL6, IL18R1
22
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9.3IL1B, IL18, IL18R1, IL6
23
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9.3IL18, IL6, IL1B, IL1R1
24
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9.3IL1B, IL6, IL1R1, IL18
25
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9.3IL1B, IL6, IL1R1, IL18
269.2IL6, IL1B, NOS2, IL1R1
27
Immune response Bacterial infections in normal airways
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9.2IL1R1, IL1B, NOS2, IL6
28
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9.2IL1B, IL1R1, IL6, NOS2
299.2NOS2, IL18, IL1B, IL6
309.2IL1B, NOS2, IL18, IL6
319.2IL1B, IL1R1, EPO, IL6
32
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9.2SPP1, NOS2, IL1B, IL6
33
Development PDGF signaling via STATs and NF-kB
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9.0NOS2, IL6, IL1B, IL18R1, IL18
348.9EPO, PDHA1, VEGFA, NOS2, IL6
358.7MBP, IL1B, IL1R1, IL6, NOS2

Compounds for genes affiliated with Leukomalacia

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 49PharmGKB, 2BitterDB
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Compounds related to Leukomalacia according to GeneCards/GeneDecks:

(show top 50)    (show all 142)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.7IL18
2estrogen4410.6NPPB
3endotoxin4410.6IL18R1
4pge24410.5VEGFA
5nmda44 2811.2APP, IL1R1, SLC1A2
6ivig449.9IL18R1, MBP, IL1R1
7norepinephrine44 11 2411.8APP, SLC1A2, MBP
8glucose449.7IL18R1, PDHA1, NPPB, SLC1A2
9anakinra44 1110.7IL18, IL6, IL1B, IL1R1
10glutamate449.7SLC1A2, MBP, APP, GRM1
11prednisolone44 28 1111.7NPPB, IL18R1, IL1R1, MBP
12indomethacin44 59 28 1112.7NPPB, SPP1, MBP, IL1R1
13vesnarinone449.6NOS2, IL6, IL18R1, IL1B
14il-12449.6IL1B, IL1R1, IL18, IL6
15cuprophan449.5EPO, IL1R1, IL1B, PTPRC
16etanercept44 49 1111.5IL6, IL1B, IL18, IL18R1, IL1R1
17oxygen44 2410.5IL18R1, EPO, NES, PDHA1, NOS2, SLC1A2
18neopterin449.4IL1R1, IL1B, IL18, IL6, IL18R1
19pentoxifylline44 1110.4IL6, IL1B, NPPB, IL18, IL1R1
20leflunomide49 44 1111.4IL6, IL18R1, IL1B, IL1R1
21heparin44 28 11 2412.3IL1R1, IL18R1, VEGFA, APP, PTPRC, SPP1
22kainate44 2810.3SLC1A2, NES, GRM1, MBP
23h2o2449.3IL1R1, PTPRC, SLC1A2, IL18, MBP
24creatinine449.3SPP1, EPO, APP, NPPB, MBP
25cyclosporin a44 28 5911.1APP, NPPB, IL18R1, IL1R1, MBP, SERPINH1
26triptolide449.0IL1B, VEGFA, NOS2, IL6
27dexamethasone44 49 28 1112.0VEGFA, APP, NPPB, SPP1, PTPRC, IL6
28epinephrine44 11 2411.0APP, IL1R1, IL18, NPPB, MBP
29hyaluronic acid44 2410.0VEGFA, IL1R1, SPP1, IL1B, IL6, PTPRC
30infliximab44 49 1110.9IL1R1, IL1B, VEGFA, SPP1, IL18R1, IL18
31thalidomide44 49 59 1111.8IL6, IL1B, IL1R1, IL18, EPO, VEGFA
32curcumin448.8NOS2, IL1B, VEGFA, SPP1, APP, IL6
33ly294002448.8IL6, NOS2, SPP1, VEGFA, IL1B, IL18
34methotrexate44 49 1110.7MBP, IL6, IL1B, IL1R1, IL18, EPO
35testosterone44 59 11 2411.6IL6, EPO, APP, IL18, NPPB, PTPRC
36actinomycin d448.5SPP1, IL1B, NOS2, NPPB, IL1R1, IL6
37sb 20358044 599.5IL18, NOS2, IL6, IL1B, IL1R1, VEGFA
38genistein44 28 59 2 11 2413.5IL6, NOS2, SPP1, IL1B, VEGFA, PTPRC
39arginine448.4APP, NPPB, IL18R1, MBP, IL1R1, SPP1
40thymidine44 249.4NPPB, IL18R1, IL18, IL1R1, IL1B, IL6
41lactate448.3IL6, NPPB, IL1R1, IL18, MBP, EPO
42alanine448.3IL18R1, IL6, SLC1A2, IL18, APP, SPP1
43n acetylcysteine448.3IL1R1, NOS2, IL1B, IL18, VEGFA, MBP
44retinoic acid44 249.2SPP1, NES, IL18R1, IL1R1, IL18, IL6
45nitric oxide44 11 2410.1IL1R1, NES, GRM1, IL18R1, IL18, SERPINH1
46cysteine448.1MBP, APP, GRM1, IL18R1, IL18, IL1R1
47cisplatin44 49 59 1111.0IL1R1, IL18R1, EPO, MBP, SPP1, IL18
48lipid448.0NES, NPPB, APP, MBP, IL18R1, IL18
49vegf447.5NPPB, SERPINH1, NOS2, IL6, IL18, IL1B
50tyrosine447.1PDHA1, MBP, NPPB, NES, IL18, IL1R1

GO Terms for genes affiliated with Leukomalacia

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16Gene Ontology
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Cellular components related to Leukomalacia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.9NPPB, VEGFA, EPO, IL18, IL1R1, IL1B
2extracellular spaceGO:0056157.8SPP1, NPPB, VEGFA, EPO, IL18, IL1B

Biological processes related to Leukomalacia according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of NF-kappaB import into nucleusGO:0423469.9IL1B, IL18, IL18R1
2positive regulation of vascular permeabilityGO:0431179.8IL18, VEGFA
3positive regulation of interferon-gamma productionGO:0327299.8IL18R1, IL18, IL1B
4embryo implantationGO:0075669.6EPO, IL1B, SPP1
5positive regulation of granulocyte macrophage colony-stimulating factor productionGO:0327259.6IL1B, IL18
6positive regulation of T cell proliferationGO:0421029.4PTPRC, IL6, IL1B
7inflammatory responseGO:0069549.1IL18, IL1B, IL6, NOS2, SPP1
8immune responseGO:0069559.0MBP, IL18R1, IL18, IL1R1, IL1B

Molecular functions related to Leukomalacia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor activityGO:00490810.1IL1R1, IL18R1
2cytokine activityGO:0051258.6SPP1, IL6, IL1B, IL18, VEGFA

Products for genes affiliated with Leukomalacia

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  • Antibodies
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Sources for Leukomalacia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet