Aliases & Classifications for Leukomalacia

MalaCards integrated aliases for Leukomalacia:

Name: Leukomalacia 50

Classifications:



Summaries for Leukomalacia

MalaCards based summary : Leukomalacia is related to periventricular leukomalacia and fetal indomethacin syndrome. An important gene associated with Leukomalacia is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Toll-Like receptor Signaling Pathways. The drugs Dopamine and Levodopa have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and heart, and related phenotypes are homeostasis/metabolism and cellular

Related Diseases for Leukomalacia

Diseases related to Leukomalacia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 108)
id Related Disease Score Top Affiliating Genes
1 periventricular leukomalacia 12.5
2 fetal indomethacin syndrome 10.8
3 smarca4-deficient sarcoma of thorax 10.8 IL6 TNF
4 aortic arch interruption 10.8 IL6 TNF
5 cutaneous leishmaniasis 10.7 IL6 TNF
6 autoimmune polyglandular syndrome type 3 10.7 SPP1 TNF
7 spirillary rat-bite fever 10.7 IL6 TNF
8 hepadnavirus infection 10.7 IL6 SLC17A5 TNF
9 early-onset zonular cataract 10.7 IL6 NOS2 TNF
10 ampulla of vater neoplasm 10.6 IL6 SLC17A5 TNF
11 acquired thrombocytopenia 10.6 IL6 NOS2 TNF
12 toxoplasmosis 10.6 IL6 TNF
13 islet cell tumor 10.6 IL6 NPPB TNF
14 placental abruption 10.6 IL6 NPPB TNF
15 low compliance bladder 10.6 NOS2 TNF
16 paranasal sinus sarcoma 10.6 IL6 SLC17A5 TNF
17 spinal stenosis 10.6 IL6 NOS2 TNF
18 alopecia 10.6 IL6 SLC17A5 TNF
19 pancreas lymphoma 10.6 IL6 NPPB TNF
20 tricho onychic dysplasia 10.6 IL6 MBP TNF
21 keratomalacia 10.6 IL6 NOS2 TNF
22 tracheal stenosis 10.6 IL6 MBP TNF
23 ulcerative colitis 10.5 IL6 MBP TNF
24 crystal arthropathies 10.5 IL1R1 IL6
25 ovarian mucinous adenofibroma 10.5 IL6 MBP TNF
26 tabatznik syndrome 10.5 IL18 TNF
27 primary biliary cirrhosis 10.5 IL1R1 IL6 TNF
28 periampullary adenoma 10.5 IL6 NPPB TNF
29 dementia pugilistica 10.5 IL6 NPPB
30 virilizing ovarian tumor 10.5 EPO IL6
31 hyperostosis 10.5 IL6 MBP MYT1
32 newborn respiratory distress syndrome 10.5 IL6 MBP SLC1A2
33 late yaws 10.5 IL6 MBP SLC17A5
34 neonatal period electroclinical syndrome 10.5 IL1R1 IL6 TNF
35 diamond-blackfan anemia 1 10.5 IL6 NPPB TNF
36 stargardt macular degeneration absent or hypoplastic corpus callosum mental retardation and dysmorphic features 10.5 IL18 IL6 TNF
37 congenital hypoplastic anemia 10.5 IL6 SLC17A5 SLC1A2 TNF
38 x-linked dominant intellectual disability-epilepsy syndrome 10.4 IL18 IL6 SLC17A5
39 reardon wilson cavanagh syndrome 10.4 IL18 IL6 TNF
40 esophagus leiomyoma 10.4 IL18 IL6 TNF
41 melioidosis 10.4 IL18 IL6 TNF
42 esophagus melanoma 10.4 IL18 IL6 TNF
43 bipolar i disorder 10.4 EPO IL6 TNF
44 lung superior sulcus carcinoma 10.4 IL6 NOS2 NPPB TNF
45 detrusor sphincter dyssynergia 10.4 IL6 NOS2 NPPB TNF
46 walker dyson syndrome 10.4 IL1R1 TNF
47 causalgia 10.3 MBP SPP1 TNF
48 cerebritis 10.3
49 blunt duct adenosis of breast 10.3 EPO SLC17A5
50 synovium cancer 10.3 IL18 IL6 TNF

Graphical network of the top 20 diseases related to Leukomalacia:



Diseases related to Leukomalacia

Symptoms & Phenotypes for Leukomalacia

MGI Mouse Phenotypes related to Leukomalacia:

44 (show all 15)
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.33 SPP1 TNF ALOX15 CHKA EPO GRM1
2 cellular MP:0005384 10.29 EPO GRM1 IL18 IL1R1 IL6 MBP
3 growth/size/body region MP:0005378 10.27 SLC17A5 SLC1A2 SPP1 TNF ALOX15 GRM1
4 behavior/neurological MP:0005386 10.24 IL18 IL1R1 IL6 MBP NOS2 SLC17A5
5 mortality/aging MP:0010768 10.2 ALOX15 CHKA EPO GRM1 IL18 IL1R1
6 cardiovascular system MP:0005385 10.18 ALOX15 EPO IL18 IL1R1 IL6 NOS2
7 hematopoietic system MP:0005397 10.18 ALOX15 EPO IL18 IL18R1 IL1R1 IL6
8 immune system MP:0005387 10.13 ALOX15 EPO IL18 IL18R1 IL1R1 IL6
9 integument MP:0010771 10.06 IL1R1 IL6 NOS2 SPP1 TNF ALOX15
10 adipose tissue MP:0005375 10.02 GRM1 IL18 IL1R1 IL6 NOS2 TNF
11 muscle MP:0005369 9.96 EPO GRM1 IL18 IL1R1 IL6 MYT1
12 liver/biliary system MP:0005370 9.91 CHKA EPO IL1R1 IL6 NOS2 SPP1
13 neoplasm MP:0002006 9.7 ALOX15 GRM1 IL1R1 IL6 NOS2 SPP1
14 nervous system MP:0003631 9.7 GRM1 IL18 IL1R1 IL6 MBP NOS2
15 vision/eye MP:0005391 9.23 TNF GRM1 IL18 IL1R1 IL6 MBP

Drugs & Therapeutics for Leukomalacia

Drugs for Leukomalacia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 142)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 3,Phase 1 51-61-6, 62-31-7 681
2
Levodopa Approved Phase 4 59-92-7 6047
3
Magnesium Sulfate Approved, Vet_approved Phase 4,Phase 3 7487-88-9 24083
4
Progesterone Approved, Vet_approved Phase 4,Phase 2,Phase 3 57-83-0 5994
5
Ibuprofen Approved Phase 4,Phase 3,Phase 2,Phase 1 15687-27-1 3672
6 Poractant alfa Approved Phase 4 129069-19-8
7
Indomethacin Approved, Investigational Phase 4,Phase 1,Phase 2 53-86-1 3715
8 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1
9 Carbidopa, levodopa drug combination Phase 4
10 Dihydroxyphenylalanine Phase 4
11 Dopamine Agents Phase 4,Phase 3,Phase 1
12 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1
13 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
14 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1
15 Analgesics Phase 4,Phase 3,Phase 1,Phase 2
16 Anesthetics Phase 4,Phase 3
17 Anti-Arrhythmia Agents Phase 4,Phase 3
18 Anticonvulsants Phase 4,Phase 3
19 calcium channel blockers Phase 4,Phase 3
20 Calcium, Dietary Phase 4,Phase 3,Phase 2
21 Central Nervous System Depressants Phase 4,Phase 3
22 Tocolytic Agents Phase 4,Phase 3,Phase 1,Phase 2
23 Pulmonary Surfactants Phase 4,Phase 3,Phase 2
24 Respiratory System Agents Phase 4,Phase 3,Phase 2
25 11-hydroxyprogesterone Phase 4,Phase 2,Phase 3
26 17-alpha-hydroxy-progesterone caproate Phase 4,Phase 2,Phase 3
27 Estrogen Antagonists Phase 4,Phase 2,Phase 3
28 Estrogens Phase 4,Phase 2,Phase 3
29 Hormone Antagonists Phase 4,Phase 2,Phase 3
30 Hormones Phase 4,Phase 2,Phase 3
31 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3
32 Progestins Phase 4,Phase 2,Phase 3
33 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 1,Phase 2
34 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 1,Phase 2
35 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 1,Phase 2
36 Antirheumatic Agents Phase 4,Phase 3,Phase 1,Phase 2
37 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 1,Phase 2
38 Caproate Nutraceutical Phase 4,Phase 2,Phase 3
39
Phenobarbital Approved Phase 3 50-06-6 4763
40
Fluconazole Approved Phase 3 86386-73-4 3365
41
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
42 Simethicone Approved Phase 3
43
Benzocaine Approved Phase 2, Phase 3 1994-09-7, 94-09-7 2337
44
Pentoxifylline Approved, Investigational Phase 3 6493-05-6 4740
45
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
46
Dalteparin Approved Phase 3 9005-49-6
47
Heparin Approved, Investigational Phase 3 9005-49-6 772 46507594
48
Betamethasone Approved, Vet_approved Phase 3 378-44-9 9782
49
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
50
Nitric Oxide Approved Phase 2, Phase 3 10102-43-9 145068

Interventional clinical trials:

(show top 50) (show all 77)

id Name Status NCT ID Phase Drugs
1 Dopamine Treatment in Children With Cerebral Palsy With Dystonia- A Double Blind Controlled Study Unknown status NCT01361373 Phase 4 L- DOPA;placebo
2 Neuroprotection by Magnesium Sulfate Given to Women at Risk of Very Preterm Birth Completed NCT00120588 Phase 4 magnesium
3 Efficacy of 17 Alpha-hydroxyprogesterones Caproate for the Prevention of Preterm Delivery Completed NCT00331695 Phase 4 17 alpha-hydroxyprogesterones caproate
4 OPTIMIST-A Trial: Minimally-invasive Surfactant Therapy in Preterm Infants 25-28 Weeks Gestation on CPAP Recruiting NCT02140580 Phase 4
5 Comparing Ibuprofen And Indomethacin For The Treatment Of The Patent Ductus Arteriosus in Very Premature Babies Withdrawn NCT00470743 Phase 4 Ibuprofen;Indomethacin
6 Magnesium Sulfate to Prevent Brain Injury in Premature Infants Unknown status NCT00065949 Phase 3 magnesium sulfate
7 Tracheal Occlusion To Accelerate Lung Growth (TOTAL) Trial for Severe Pulmonary Hypoplasia Unknown status NCT01240057 Phase 2, Phase 3
8 Premature Infants in Need of Transfusion (PINT) Completed NCT00182390 Phase 3
9 Antenatal Phenobarbital to Prevent Neonatal Intracranial Hemorrhage Completed NCT00009620 Phase 3 Phenobarbital;Saline
10 Beneficial Effects of Antenatal Magnesium Sulfate (BEAM Trial) Completed NCT00014989 Phase 3 magnesium sulfate
11 17OHP for Reduction of Neonatal Morbidity Due to Preterm Birth (PTB) in Twin and Triplet Pregnancies Completed NCT00163020 Phase 2, Phase 3 17-alpha-hydroxyprogesterone caproate injectable;Placebo
12 Fluconazole Prophylaxis for the Prevention of Candidiasis in Infants Less Than 750 Grams Birthweight Completed NCT00734539 Phase 3 fluconazole;placebo
13 NIV Strategies for RDS in Preterm Infants. NIV (Non Invasive Ventilation), RDS (Respiratory Distress Syndrome) Completed NCT02259400 Phase 2, Phase 3
14 Surfactant Positive Airway Pressure and Pulse Oximetry Trial Completed NCT00233324 Phase 3 Surfactant;Supplemental oxygen with target saturation of 85 to 89%;Supplemental oxygen with target saturation of 91 to 95%
15 Caffeine for Apnea of Prematurity (CAP) Completed NCT00182312 Phase 3 Caffeine citrate injection
16 Pentoxifylline and Late Onset Sepsis in Preterm Infants Completed NCT02163174 Phase 3 Pentoxifylline (PTX);Placebo
17 High Versus Low Dose of Caffeine for Apnea of Prematurity Completed NCT02103777 Phase 3 Caffeine citrate
18 Safety and Efficacy Study of Ibuprofen l-Lysine Solution in Premature Infants for Treatment of PDA Completed NCT00440804 Phase 3 ibuprofen l-lysine iv solution (NeoProfen (R) )
19 Omega-3 Fatty Acid Supplementation to Prevent Preterm Birth in High Risk Pregnancies Completed NCT00135902 Phase 3 17 alpha-Hydroxyprogesterone Caproate and Omega-3 fish oils
20 Trial of Aggressive Versus Conservative Phototherapy in Infants <1,000 Grams Birth Weight Completed NCT00114543 Phase 3
21 Trial of Progesterone in Twins and Triplets to Prevent Preterm Birth (STTARS) Completed NCT00099164 Phase 3 17 alpha-hydroxyprogesterone caproate (17P)
22 Prevention of Maternal and Perinatal Complications by Enoxaparin in Women With Previous Severe Preeclampsia Completed NCT00986765 Phase 3 Lovenox® (enoxaparin);Aspegic ® (Aspirin)
23 Effect of Erythropoietin in Premature Infants on White Matter Lesions and Neurodevelopmental Outcome Recruiting NCT03110341 Phase 3 Erythropoietin;Normal saline
24 Management of Hypotension In the Preterm Infant Recruiting NCT01482559 Phase 3 Dopamine hydrochloride;Dextrose 5%
25 Maternal Omega-3 Supplementation to Reduce Bronchopulmonary Dysplasia Recruiting NCT02371460 Phase 3
26 Dose Reduction of Antenatal Betamethasone Given to Prevent the Neonatal Complications Associated With Very Preterm Birth Recruiting NCT02897076 Phase 3 betamethasone 24 mg;12mg betamethasone +placebo
27 Inhaled Nitric Oxide and Neuroprotection in Premature Infants Active, not recruiting NCT00515281 Phase 2, Phase 3 inhaled nitric oxide;oxygen
28 Efficacy and Safety of Goat Lung Surfactant for the Treatment of Respiratory Distress Syndrome in Preterm Neonates Not yet recruiting NCT02774044 Phase 2, Phase 3 Cadisurf;Survanta
29 Probiotics for the Prevention of Premature Birth and Neonatal Related Morbidity Terminated NCT00303082 Phase 3 Lactobacillus rhamnosus GR1 and Lactobacillus reuteri RC-14
30 Minimal Breathing Support and Early Steroids to Prevent Chronic Lung Disease in Extremely Premature Infants (SAVE) Terminated NCT00005777 Phase 3 Dexamethasone;Placebo
31 Recombinant Erythropoietin for Neuroprotection in Very Preterm Infants Unknown status NCT00910234 Phase 1, Phase 2 recombinant human erythropoietin (rhEpo);recombinant human erythropoietin (rhEpo);Normal saline
32 Minimally Invasive Surfactant Therapy Followed by CPAP (MISTCPAP) in Preterm Infants With RDS Unknown status NCT01723683 Phase 2 Surfactant
33 Does Erythropoietin Improve Outcome in Very Preterm Infants? Completed NCT00413946 Phase 2 Recombinant human Erythropoietin;saline
34 High-frequency Oscillatory Ventilation (HFOV) in Preterm Infants With Severe Respiratory Distress Syndrome (RDS) Completed NCT01496508 Phase 2
35 Effects of Delayed Cord Clamp and/or Indomethacin on Preterm Infant Brain Injury Recruiting NCT02221219 Phase 1, Phase 2 Indomethacin;placebo infusion
36 Randomized Trial of Maternal Progesterone Therapy Recruiting NCT02133573 Phase 2 Progesterone;Vaginal lubricant
37 The Synergistic Pharmacologic Intervention for Prevention of ROP (SPIPROP Study) Recruiting NCT02344225 Phase 2 Caffeine citrate;Ibuprofen;Ketorolac
38 Antibiotic "Dysbiosis" in Preterm Infants Recruiting NCT02784821 Phase 2 Antibiotic;Antibiotics - pre-emptive
39 'TOTAL' (Tracheal Occlusion To Accelerate Lung Growth) Trial Recruiting NCT02875860 Phase 2
40 Probiotics Reduce Incidence of Necrotizing Enterocolitis for Very Low Birth Weight Infants Terminated NCT00540033 Phase 2
41 Dobutamine in the Treatment of Haemodynamic Insufficiency in the Immediate Postnatal Period Terminated NCT03311178 Phase 1, Phase 2 Dobutamine
42 High-Dose Erythropoietin in Extremely Premature Infants to Prevent/Attenuate Brain Injury: A Phase II Study Terminated NCT00589953 Phase 2 Erythropoietin;Saline placebo
43 A Trial of Infant Flow Biphasic Nasal Continuous Airway Pressure (NCPAP) Versus Infant Flow NCPAP for the Facilitation of Extubation in Infants </= 1250 Grams Terminated NCT00308789 Phase 2
44 Feasibility Study of Aerosolized Surfaxin in the Prevention of Respiratory Distress Syndrome (RDS) in Premature Infants Terminated NCT00807235 Phase 2 Aerosolized lucinactant;Aerosolized lucinactant
45 Inhaled PGE1 in Neonatal Hypoxemic Respiratory Failure Withdrawn NCT00598429 Phase 2 Inhaled Prostaglandin E1
46 Early Blood Pressure Management in Extremely Premature Infants Completed NCT00874393 Phase 1 Dopamine;Hydrocortisone;Infusion Placebo;Syringe Placebo
47 Combination of Acetaminophen and Ibuprofen in the Management of Patent Ductus Arteriosus Recruiting NCT03103022 Phase 1 Acetaminophen;ibuprofen
48 S100B as a Marker of Brain Injury of Preterm Infants Unknown status NCT02082535
49 Use of Blended Oxygen for Delivery Room Resuscitation of Very Low Birth Weight Infants Unknown status NCT00369720
50 Telerehabilitation of Working Memory in Children With Periventricular Leukomalacia and Bilateral Cerebral Palsy Completed NCT02342990

Search NIH Clinical Center for Leukomalacia

Genetic Tests for Leukomalacia

Anatomical Context for Leukomalacia

MalaCards organs/tissues related to Leukomalacia:

39
Brain, Lung, Heart, Cortex, Thalamus, Pons, Endothelial

Publications for Leukomalacia

Articles related to Leukomalacia:

(show top 50) (show all 424)
id Title Authors Year
1
Upper Limb Function, Kinematic Analysis, and Dystonia Assessment in Children With Spastic Diplegic Cerebral Palsy and Periventricular Leukomalacia. ( 28776460 )
2017
2
Association between perinatal hypoxic-ischemia and periventricular leukomalacia in preterm infants: A systematic review and meta-analysis. ( 28931047 )
2017
3
A model of Periventricular Leukomalacia (PVL) in neonate mice with histopathological and neurodevelopmental outcomes mimicking human PVL in neonates. ( 28406931 )
2017
4
Intranasal surfactant protein D as neuroprotective rescue in a neonatal rat model of periventricular leukomalacia. ( 27109442 )
2016
5
The vulnerability of thalamocortical circuitry to hypoxic-ischemic injury in a mouse model of periventricular leukomalacia. ( 26733225 )
2016
6
Isolated Cystic Periventricular Leukomalacia Differs from Cystic Periventricular Leukomalacia with Intraventricular Hemorrhage in Prevalence, Risk Factors and Outcomes in Preterm Infants. ( 27643988 )
2016
7
Quality of Life of Children with Cystic Periventricular Leukomalacia - A Prospective Analysis with the Child Health Questionnaire-Parent Form 50. ( 27242979 )
2016
8
Diffusion-Weighted Imaging of Periventricular Leukomalacia in Very Young Children: Assessment of Peritrigonal Stripe of Restricted Diffusion. ( 28030870 )
2016
9
Slow pupillary light responses in infants at high risk of cerebral palsy were associated with periventricular leukomalacia and neurological outcome. ( 27468114 )
2016
10
The association between pro- and anti-inflammatory cytokine polymorphisms and periventricular leukomalacia in newborns with hypoxic-ischemic encephalopathy. ( 27217792 )
2016
11
Periventricular leukomalacia in a neonatal calf. ( 27010465 )
2016
12
Chloride cotransporter NKCC1 inhibitor bumetanide protects against white matter injury in a rodent model of periventricular leukomalacia. ( 25585037 )
2015
13
Scoring system for periventricular leukomalacia in infants with congenital heart disease. ( 25996891 )
2015
14
Relation between prognosis and changes of MBP and S100B in premature infants with periventricular leukomalacia. ( 25966206 )
2015
15
Screening Cranial Imaging at Multiple Time Points Improves Cystic Periventricular Leukomalacia Detection. ( 25730135 )
2015
16
Bioinformatics analyses combined microarray identify the differentially expressed microRNAs in periventricular leukomalacia. ( 26812286 )
2015
17
Antenatal exposure to indomethacin increases the risk of severe intraventricular hemorrhage, necrotizing enterocolitis, and periventricular leukomalacia: a systematic review with metaanalysis. ( 25448524 )
2015
18
Relationship between white matter integrity and severity of motor impairment in children with cerebral palsy caused by periventricular leukomalacia. ( 26531639 )
2015
19
Impact of risk factors other than prematurity on periventricular leukomalacia. A population-based matched case control study. ( 25748489 )
2015
20
The Effects of the Severity of Periventricular Leukomalacia on the Neuropsychological Outcomes of Preterm Children. ( 26385973 )
2015
21
Increased fetal heart rate variability in periventricular leukomalacia. ( 26338690 )
2015
22
Corticospinal Tract Injury Precedes Thalamic Volume Reduction in Preterm Infants with Cystic Periventricular Leukomalacia. ( 26054943 )
2015
23
Two important factors affecting the transition to breastfeeding in preterm infants: corrected age and periventricular leukomalacia. ( 26265900 )
2015
24
Clinical study of cerebral palsy in 408 children with periventricular leukomalacia. ( 25780432 )
2015
25
The whole spectrum of cystic periventricular leukomalacia of the preterm infant: results from a large consecutive case series. ( 26099229 )
2015
26
Latency after preterm prelabor rupture of the membranes: increased risk for periventricular leukomalacia. ( 25136457 )
2014
27
Severe cystic periventricular leukomalacia in a premature infant with capnocytophaga sepsis. ( 25452885 )
2014
28
Visual Evoked Potentials in Infants with Diffuse Periventricular Leukomalacia. ( 24615931 )
2014
29
Retinal vessel pathologies in a rat model of periventricular leukomalacia: a new model for retinopathy of prematurity? ( 25698709 )
2014
30
Texture analysis of periventricular echogenicity on neonatal cranial ultrasound predicts periventricular leukomalacia. ( 24246513 )
2013
31
Epileptic Encephalopathy With Continuous Spike and Wave During Sleep Associated to Periventricular Leukomalacia. ( 24293309 )
2013
32
12/15-lipoxygenase expression is increased in oligodendrocytes and microglia of periventricular leukomalacia. ( 23838566 )
2013
33
Preterm twin and triplet pregnancies are at increased risk for the development of cystic periventricular leukomalacia. ( 22795624 )
2013
34
Visuospatial working memory in toddlers with a history of periventricular Leukomalacia: an EEG narrow-band power analysis. ( 23922816 )
2013
35
Discovering hidden relationships in physiological signals for prediction of Periventricular Leukomalacia. ( 24111376 )
2013
36
The expression profile of microRNAs in wistar rats with lipopolysaccharide-induced periventricular leukomalacia. ( 23354881 )
2013
37
Diffusion tensor imaging-demonstrated differences between hemiplegic and diplegic cerebral palsy with symmetric periventricular leukomalacia. ( 22976239 )
2013
38
Spontaneous movements in the supine position of healthy term infants and preterm infants with or without periventricular leukomalacia. ( 22656321 )
2013
39
Ischemia-induced neuroinflammation is associated with disrupted development of oligodendrocyte progenitors in a model of periventricular leukomalacia. ( 23445614 )
2013
40
Neurodevelopmental outcomes of children with periventricular leukomalacia. ( 23727042 )
2013
41
Diphenyleneiodonium protects preoligodendrocytes against endotoxin-activated microglial NADPH oxidase-generated peroxynitrite in a neonatal rat model of periventricular leukomalacia. ( 23174417 )
2013
42
Using the Alberta Infant Motor Scale to early identify very low-birth-weight infants with cystic periventricular leukomalacia. ( 21959127 )
2013
43
Risk factors for preoperative periventricular leukomalacia in term neonates with hypoplastic left heart syndrome are patient related. ( 23879933 )
2013
44
White matter loss in a mouse model of periventricular leukomalacia is rescued by trophic factors. ( 24961618 )
2013
45
Amplitude-integrated electroencephalogram 1 h after birth in a preterm infant with cystic periventricular leukomalacia. ( 22196997 )
2013
46
Differences between periventricular hemorrhagic infarction and periventricular leukomalacia. ( 23978489 )
2013
47
Potential of diffusion tensor MR imaging in the assessment of cognitive impairments in children with periventricular leukomalacia born preterm. ( 23084875 )
2013
48
Prediction of Periventricular Leukomalacia Occurrence in Neonates After Heart Surgery. ( 24122606 )
2013
49
Periventricular leukomalacia and less invasive surfactant administration in extremely preterm infants. Concerning the article by k. Klebermass-schrehof et Al.: less invasive surfactant administration in extremely preterm infants: impact on mortality and morbidity [neonatology 2013;103:252-258]. ( 23817316 )
2013
50
Epilepsy in children with periventricular leukomalacia. ( 23891141 )
2013

Variations for Leukomalacia

Expression for Leukomalacia

Search GEO for disease gene expression data for Leukomalacia.

Pathways for Leukomalacia

Pathways related to Leukomalacia according to GeneCards Suite gene sharing:

(show all 31)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.29 ALOX15 IL18 IL18R1 IL1R1 IL6 NOS2
2
Show member pathways
12.89 IL18 IL18R1 IL1R1 IL6 NOS2 TNF
3
Show member pathways
12.46 IL18 IL18R1 IL1R1 IL6 TNF
4
Show member pathways
12.44 IL18 IL18R1 IL6 NOS2 TNF
5
Show member pathways
12.18 IL1R1 IL6 NOS2 TNF
6 12.15 IL18 IL6 NOS2 TNF
7
Show member pathways
12.08 IL1R1 IL6 NOS2 TNF
8 11.86 IL18R1 IL6 TNF
9
Show member pathways
11.79 IL18 IL18R1 IL1R1 NOS2
10 11.78 IL18 IL6 TNF
11 11.75 IL18 IL6 NOS2
12
Show member pathways
11.73 IL18 IL18R1 IL6 TNF
13 11.72 IL18 IL1R1 TNF
14 11.68 IL6 NOS2 TNF
15 11.66 EPO IL6 NOS2 PDHA1
16 11.64 IL6 NOS2 TNF
17 11.61 EPO IL1R1 IL6 TNF
18 11.59 IL6 SPP1 TNF
19
Show member pathways
11.59 IL6 NOS2 TNF
20 11.54 IL1R1 IL6 NOS2 TNF
21 11.51 IL18 IL6 TNF
22 11.43 IL18 IL6 TNF
23 11.43 IL1R1 IL6 MBP NOS2 TNF
24 11.4 IL18 NOS2 TNF
25 11.37 IL6 SPP1 TNF
26 11.24 EPO NOS2 PDHA1
27 11.2 IL18 IL6 TNF
28 11.15 IL18 IL1R1 IL6 TNF
29 11.14 IL18 IL6 TNF
30 11.08 ALOX15 IL18 IL6 NOS2 TNF
31 10.45 CHKA PDHA1

GO Terms for Leukomalacia

Biological processes related to Leukomalacia according to GeneCards Suite gene sharing:

(show all 17)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.76 ALOX15 EPO IL6 TNF
2 positive regulation of protein kinase B signaling GO:0051897 9.72 IL18 IL6 TNF
3 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.65 EPO IL18 IL6
4 immune response GO:0006955 9.63 IL18 IL18R1 IL1R1 IL6 MBP TNF
5 response to lipopolysaccharide GO:0032496 9.61 EPO IL6 NOS2
6 positive regulation of smooth muscle cell proliferation GO:0048661 9.58 IL18 IL6 TNF
7 positive regulation of chemokine production GO:0032722 9.57 IL6 TNF
8 phosphatidylethanolamine biosynthetic process GO:0006646 9.56 ALOX15 CHKA
9 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.54 ALOX15 TNF
10 negative regulation of lipid storage GO:0010888 9.52 IL6 TNF
11 response to salt stress GO:0009651 9.51 EPO TNF
12 positive regulation of interferon-gamma production GO:0032729 9.5 IL18 IL18R1 TNF
13 positive regulation of T-helper 2 cell differentiation GO:0045630 9.49 IL18 IL6
14 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.37 IL6 TNF
15 interleukin-18-mediated signaling pathway GO:0035655 9.26 IL18 IL18R1
16 positive regulation of NF-kappaB import into nucleus GO:0042346 9.13 IL18 IL18R1 TNF
17 inflammatory response GO:0006954 9.02 ALOX15 IL18 IL6 SPP1 TNF

Molecular functions related to Leukomalacia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.33 IL1R1 MBP TNF
2 cytokine activity GO:0005125 9.26 IL18 IL6 SPP1 TNF
3 interleukin-1 receptor activity GO:0004908 8.62 IL18R1 IL1R1

Sources for Leukomalacia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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