MCID: LKM006
MIFTS: 33

Leukomalacia malady

Rare diseases category

Summaries for Leukomalacia

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Sources:
66Wikipedia, 34MalaCards
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Wikipedia:66 Periventricular leukomalacia (PVL) is a form of white-matter brain injury, characterized by the necrosis... more...

MalaCards: Leukomalacia is related to periventricular leukomalacia and cerebritis. An important gene associated with Leukomalacia is NES (nestin), and among its related pathways is Integrated Pancreatic Cancer Pathway. The compounds ganglioside and choline have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and heart, and related mouse phenotype muscle.

Aliases & Classifications for Leukomalacia

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44NIH Rare Diseases
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

leukomalacia 44


Related Diseases for Leukomalacia

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Leukomalacia:



Diseases related to leukomalacia

Symptoms for Leukomalacia

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Drugs & Therapeutics for Leukomalacia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Leukomalacia

Drug clinical trials:

Search ClinicalTrials for Leukomalacia

Search NIH Clinical Center for Leukomalacia

Search CenterWatch for Leukomalacia

Genetic Tests for Leukomalacia

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Anatomical Context for Leukomalacia

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34MalaCards
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MalaCards organs/tissues related to Leukomalacia:

34
Brain, Cortex, Heart, Eye, Cerebellum, Placenta, Endothelial, Thalamus, Pons

Animal Models for Leukomalacia or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Leukomalacia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.5PDHA1, MYT1, APP

Publications for Leukomalacia

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53PubMed
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Articles related to Leukomalacia:

(show top 50)    (show all 392)
idTitleAuthorsYear
1
Texture analysis of periventricular echogenicity on neonatal cranial ultrasound predicts periventricular leukomalacia. (24246513)
2013
2
Visuospatial working memory in toddlers with a history of periventricular Leukomalacia: an EEG narrow-band power analysis. (23922816)
2013
3
Preterm twin and triplet pregnancies are at increased risk for the development of cystic periventricular leukomalacia. (22795624)
2013
4
Periventricular leukomalacia long-term prognosis may be improved by treatment with UDP-glucose, GDNF, and memantine in neonatal rats. (23022311)
2012
5
Neonatal absolute nucleated red blood cell counts do not predict the development of cystic periventricular leukomalacia. (22953617)
2012
6
Risk factors for isolated periventricular leukomalacia. (22353288)
2012
7
Application of decision tree in the prediction of periventricular leukomalacia (PVL) occurrence in neonates after heart surgery. (23367279)
2012
8
Episodes of hypocarbia and early-onset sepsis are risk factors for cystic periventricular leukomalacia in the preterm infant. (21752559)
2012
9
Hypoxia-ischemia induces hypo-phosphorylation of collapsin response mediator protein 2 in a neonatal rat model of periventricular leukomalacia. (21333637)
2011
10
Amplitude-integrated electroencephalography in preterm infants with cystic periventricular leukomalacia. (21237587)
2011
11
Gray matter volume decrements in preterm children with periventricular leukomalacia. (21386751)
2011
12
Mouse models of periventricular leukomalacia. (20485263)
2010
13
Relationship between enlargement of the lateral ventricle and periventricular leukomalacia in infants. (21058436)
2010
14
Studies on the value of diffusion-weighted MR imaging in the early prediction of periventricular leukomalacia. (18393955)
2009
15
High postnatal oxidative stress in neonatal cystic periventricular leukomalacia. (19091500)
2009
16
Obstetric risk factors associated with the development of periventricular leukomalacia in preterm infants born to mothers complicated by placenta previa. (18849607)
2008
17
Periventricular leukomalacia in premature infants in mainland China. (18843588)
2008
18
Pretreatment with low doses of erythropoietin ameliorates brain damage in periventricular leukomalacia by targeting late oligodendrocyte progenitors: a rat model. (18784421)
2008
19
Diffusion tensor imaging in children with periventricular leukomalacia: variability of injuries to white matter tracts. (17698519)
2007
20
Neurological examination at 6 to 9 months in infants with cystic periventricular leukomalacia. (17177152)
2006
21
Possible antenatal and perinatal related factors in development of cystic periventricular leukomalacia. (15626536)
2005
22
Myelin transcription factor 1 (MyT1) immunoreactivity in infants with periventricular leukomalacia. (12524179)
2003
23
Possible correlation between high levels of IL-18 in the cord blood of pre-term infants and neonatal development of periventricular leukomalacia and cerebral palsy. (11895335)
2002
24
Periventricular leukomalacia: pathophysiological concerns due to immature development of the brain. (12506812)
2002
25
Spontaneous leg movements in infants with and without periventricular leukomalacia: effects of unilateral weighting. (11809498)
2002
26
Periventricular leukomalacia, inflammation and white matter lesions within the developing nervous system. (12416551)
2002
27
Relation between the date of cyst formation observable on ultrasonography and the timing of injury determined by serial electroencephalography in preterm infants with periventricular leukomalacia. (11578849)
2001
28
Inflammatory cytokines in the pathogenesis of periventricular leukomalacia. (11376173)
2001
29
Development of spontaneous leg movements in infants with and without periventricular leukomalacia. (11104131)
2000
30
Periventricular leukomalacia and tumor necrosis factor. (11221705)
2000
31
Neuromotor spectrum of periventricular leukomalacia in children born at term. (11020641)
2000
32
Periventricular leukomalacia and epilepsy: incidence and seizure pattern. (9932954)
1999
33
Growth of preterm infants with cystic periventricular leukomalacia. (9766734)
1998
34
18F]-fluorodeoxyglucose-positron emission tomography findings in protein infants with severe periventricular leukomalacia and hypsarrhythmia. (9083768)
1997
35
Ultrasonographic findings in the periventricular region in premature newborns with antenatal periventricular leukomalacia. (9189838)
1997
36
Early cerebral proton MRS and neurodevelopmental outcome in infants with cystic leukomalacia. (9233361)
1997
37
Periventricular leukomalacia, glial development and myelination. (8903762)
1995
38
Bilateral carotid artery occlusion causes periventricular leukomalacia in neonatal dogs. (8026082)
1994
39
Cerebral palsy of cystic periventricular leukomalacia in low-birth-weight infants. (8025396)
1994
40
Prognostic value of early somatosensory evoked potentials in neonates with cystic leukomalacia. (8335158)
1993
41
Special imaging casebook. Periventricular leukomalacia. (8345392)
1993
42
Neuroimaging and functional outcome of neonatal leukomalacia. (1388803)
1992
43
Evolution of periventricular leukomalacia during the neonatal period and infancy: correlation of imaging and postmortem findings. (3061775)
1988
44
Neurosonographic and biochemical correlates of periventricular leukomalacia in low-birth-weight infants. (3325953)
1987
45
Neonatal periventricular leukomalacia: diagnosis and evolution evaluated by real-time ultrasound. (3546212)
1986
46
Neonatal periventricular leukomalacia: real-time sonographic diagnosis with CT correlation. (3873838)
1985
47
Periventricular leukomalacia: a correlation study between real-time ultrasound and autopsy findings. Periventricular leukomalacia in the neonate. (3900799)
1985
48
Cystic periventricular leukomalacia: sonographic and CT findings. (6431779)
1984
49
Periventricular leukomalacia complex. Clinical and pathologic correlates. (6895832)
1982
50
Radiological Diagnosis of Periventricular and Subcortical Leukomalacia. (6968416)
1980

Variations for Leukomalacia

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Expression for genes affiliated with Leukomalacia

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Leukomalacia

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Pathways for genes affiliated with Leukomalacia

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51PathCards, 39NCBI BioSystems Database
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Pathways related to Leukomalacia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3MYT1, APP

Compounds for genes affiliated with Leukomalacia

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46Novoseek, 25HMDB, 12DrugBank, 52PharmGKB
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Compounds related to Leukomalacia according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1ganglioside469.7NES, APP
2choline46 25 1211.5NES, APP
3gaba469.4NES, APP
4tacrolimus46 52 1211.3APP, IL18R1
5gnrh469.3NES, APP
6vegf469.1IL18R1, NES, APP
7glutamate469.1APP, NES, IL18R1
8retinoic acid46 2510.1IL18R1, NES, APP
9oxygen46 259.9PDHA1, IL18R1, NES
10glucose468.7PDHA1, IL18R1, NES
11cysteine468.7APP, IL18R1, PDHA1
12lipid468.6IL18R1, NES, APP

GO Terms for genes affiliated with Leukomalacia

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Products for genes affiliated with Leukomalacia

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Sources for Leukomalacia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet