MCID: LKM006
MIFTS: 33

Leukomalacia malady

Rare diseases category
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Summaries for Leukomalacia

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Wikipedia:65 Periventricular leukomalacia (PVL) is a form of white-matter brain injury, characterized by the necrosis... more...

MalaCards based summary: Leukomalacia is related to periventricular leukomalacia and cerebritis. An important gene associated with Leukomalacia is NES (nestin), and among its related pathways is Integrated Pancreatic Cancer Pathway. The compounds ganglioside and choline have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and heart, and related mouse phenotype muscle.

Aliases & Classifications for Leukomalacia

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Leukomalacia, Aliases & Descriptions:

Name: Leukomalacia 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Leukomalacia

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Graphical network of the top 20 diseases related to Leukomalacia:



Diseases related to leukomalacia

Symptoms for Leukomalacia

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Drugs & Therapeutics for Leukomalacia

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Drug clinical trials:

Search ClinicalTrials for Leukomalacia

Search NIH Clinical Center for Leukomalacia

Genetic Tests for Leukomalacia

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Anatomical Context for Leukomalacia

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MalaCards organs/tissues related to Leukomalacia:

32
Brain, Cortex, Heart, Eye, Cerebellum, Placenta, Endothelial, Thalamus, Pons

Animal Models for Leukomalacia or affiliated genes

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MGI Mouse Phenotypes related to Leukomalacia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.5PDHA1, MYT1, APP

Publications for Leukomalacia

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Articles related to Leukomalacia:

(show top 50)    (show all 393)
idTitleAuthorsYear
1
Texture analysis of periventricular echogenicity on neonatal cranial ultrasound predicts periventricular leukomalacia. (24246513)
2013
2
Visuospatial working memory in toddlers with a history of periventricular Leukomalacia: an EEG narrow-band power analysis. (23922816)
2013
3
Preterm twin and triplet pregnancies are at increased risk for the development of cystic periventricular leukomalacia. (22795624)
2013
4
Periventricular leukomalacia long-term prognosis may be improved by treatment with UDP-glucose, GDNF, and memantine in neonatal rats. (23022311)
2012
5
Neonatal absolute nucleated red blood cell counts do not predict the development of cystic periventricular leukomalacia. (22953617)
2012
6
Risk factors for isolated periventricular leukomalacia. (22353288)
2012
7
Application of decision tree in the prediction of periventricular leukomalacia (PVL) occurrence in neonates after heart surgery. (23367279)
2012
8
Episodes of hypocarbia and early-onset sepsis are risk factors for cystic periventricular leukomalacia in the preterm infant. (21752559)
2012
9
Hypoxia-ischemia induces hypo-phosphorylation of collapsin response mediator protein 2 in a neonatal rat model of periventricular leukomalacia. (21333637)
2011
10
Amplitude-integrated electroencephalography in preterm infants with cystic periventricular leukomalacia. (21237587)
2011
11
Gray matter volume decrements in preterm children with periventricular leukomalacia. (21386751)
2011
12
Mouse models of periventricular leukomalacia. (20485263)
2010
13
Relationship between enlargement of the lateral ventricle and periventricular leukomalacia in infants. (21058436)
2010
14
Studies on the value of diffusion-weighted MR imaging in the early prediction of periventricular leukomalacia. (18393955)
2009
15
High postnatal oxidative stress in neonatal cystic periventricular leukomalacia. (19091500)
2009
16
Neonatal MRI in preterm infants with periventricular leukomalacia and mild disability. (19419519)
2009
17
Obstetric risk factors associated with the development of periventricular leukomalacia in preterm infants born to mothers complicated by placenta previa. (18849607)
2008
18
Periventricular leukomalacia in premature infants in mainland China. (18843588)
2008
19
Pretreatment with low doses of erythropoietin ameliorates brain damage in periventricular leukomalacia by targeting late oligodendrocyte progenitors: a rat model. (18784421)
2008
20
Diffusion tensor imaging in children with periventricular leukomalacia: variability of injuries to white matter tracts. (17698519)
2007
21
Neurological examination at 6 to 9 months in infants with cystic periventricular leukomalacia. (17177152)
2006
22
Possible antenatal and perinatal related factors in development of cystic periventricular leukomalacia. (15626536)
2005
23
Myelin transcription factor 1 (MyT1) immunoreactivity in infants with periventricular leukomalacia. (12524179)
2003
24
Possible correlation between high levels of IL-18 in the cord blood of pre-term infants and neonatal development of periventricular leukomalacia and cerebral palsy. (11895335)
2002
25
Periventricular leukomalacia: pathophysiological concerns due to immature development of the brain. (12506812)
2002
26
Spontaneous leg movements in infants with and without periventricular leukomalacia: effects of unilateral weighting. (11809498)
2002
27
Periventricular leukomalacia, inflammation and white matter lesions within the developing nervous system. (12416551)
2002
28
Relation between the date of cyst formation observable on ultrasonography and the timing of injury determined by serial electroencephalography in preterm infants with periventricular leukomalacia. (11578849)
2001
29
Inflammatory cytokines in the pathogenesis of periventricular leukomalacia. (11376173)
2001
30
Development of spontaneous leg movements in infants with and without periventricular leukomalacia. (11104131)
2000
31
Periventricular leukomalacia and tumor necrosis factor. (11221705)
2000
32
Periventricular leukomalacia and epilepsy: incidence and seizure pattern. (9932954)
1999
33
Growth of preterm infants with cystic periventricular leukomalacia. (9766734)
1998
34
18F]-fluorodeoxyglucose-positron emission tomography findings in protein infants with severe periventricular leukomalacia and hypsarrhythmia. (9083768)
1997
35
Ultrasonographic findings in the periventricular region in premature newborns with antenatal periventricular leukomalacia. (9189838)
1997
36
Early cerebral proton MRS and neurodevelopmental outcome in infants with cystic leukomalacia. (9233361)
1997
37
Periventricular leukomalacia, glial development and myelination. (8903762)
1995
38
Bilateral carotid artery occlusion causes periventricular leukomalacia in neonatal dogs. (8026082)
1994
39
Cerebral palsy of cystic periventricular leukomalacia in low-birth-weight infants. (8025396)
1994
40
Prognostic value of early somatosensory evoked potentials in neonates with cystic leukomalacia. (8335158)
1993
41
Special imaging casebook. Periventricular leukomalacia. (8345392)
1993
42
Neuroimaging and functional outcome of neonatal leukomalacia. (1388803)
1992
43
Evolution of periventricular leukomalacia during the neonatal period and infancy: correlation of imaging and postmortem findings. (3061775)
1988
44
Neurosonographic and biochemical correlates of periventricular leukomalacia in low-birth-weight infants. (3325953)
1987
45
Neonatal periventricular leukomalacia: diagnosis and evolution evaluated by real-time ultrasound. (3546212)
1986
46
Neonatal periventricular leukomalacia: real-time sonographic diagnosis with CT correlation. (3873838)
1985
47
Periventricular leukomalacia: a correlation study between real-time ultrasound and autopsy findings. Periventricular leukomalacia in the neonate. (3900799)
1985
48
Cystic periventricular leukomalacia: sonographic and CT findings. (6431779)
1984
49
Periventricular leukomalacia complex. Clinical and pathologic correlates. (6895832)
1982
50
Radiological Diagnosis of Periventricular and Subcortical Leukomalacia. (6968416)
1980

Variations for Leukomalacia

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Expression for genes affiliated with Leukomalacia

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Expression patterns in normal tissues for genes affiliated with Leukomalacia

Search GEO for disease gene expression data for Leukomalacia.

Pathways for genes affiliated with Leukomalacia

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Pathways related to Leukomalacia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3MYT1, APP

Compounds for genes affiliated with Leukomalacia

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 50PharmGKB
See all sources

Compounds related to Leukomalacia according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1ganglioside449.7NES, APP
2choline44 24 1111.5NES, APP
3gaba449.4NES, APP
4tacrolimus44 50 1111.3APP, IL18R1
5gnrh449.3NES, APP
6vegf449.1IL18R1, NES, APP
7glutamate449.1APP, NES, IL18R1
8retinoic acid44 2410.1IL18R1, NES, APP
9oxygen44 249.9PDHA1, IL18R1, NES
10glucose448.7PDHA1, IL18R1, NES
11cysteine448.7APP, IL18R1, PDHA1
12lipid448.6IL18R1, NES, APP

GO Terms for genes affiliated with Leukomalacia

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Products for genes affiliated with Leukomalacia

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  • Antibodies
  • Proteins
  • Lysates

Sources for Leukomalacia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet