MCID: LKP004
MIFTS: 44

Leukopenia malady

Summaries for Leukopenia

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66Wikipedia, 34MalaCards
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Wikipedia:66 Leukopenia (also known as leukocytopenia, or leucopenia, from Greek ????? - white and ????? -deficiency)... more...

MalaCards: Leukopenia is related to thrombocytopenia and leukemia. An important gene associated with Leukopenia is ITPA (inosine triphosphatase (nucleoside triphosphate pyrophosphatase)), and among its related pathways are One carbon pool by folate and Heparan sulfate/heparin (HS-GAG) metabolism. The compounds purine analogues and acetaminophen glucuronide have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and bone, and related mouse phenotypes are hematopoietic system and growth/size/body.

Aliases & Classifications for Leukopenia

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11DISEASES, 46Novoseek, 63UMLS
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Aliases & Descriptions:

leukopenia 11 46 63


Related Diseases for Leukopenia

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18GeneCards, 19GeneDecks
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Diseases related to Leukopenia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 163)
idRelated DiseaseScoreTop Affiliating Genes
1thrombocytopenia31.0ABCB7, IDUA, GUSB, TPMT, SLC17A5
2leukemia30.5HLA-G, IDUA, GUSB, TPMT
3hepatitis30.3SLC17A5, GUSB
4inflammatory bowel disease30.2ITPA, TPMT
5rheumatoid arthritis30.2BPI, TPMT, GUSB, HLA-G
6acute leukemia30.2HLA-G, IDUA, TPMT
7vasculitis30.2TPMT, BPI
8pancreatitis30.1SLC17A5, ITPA, TPMT
9bacteremia30.1GUSB, BPI
10liver cirrhosis30.0ABCB7, BPI, SLC17A5
11gaucher's disease29.9GUSB, IDUA
12alcohol abuse29.8SLC17A5, ABCB7
13hepatitis b29.8SLC17A5, ABCB7
14hepatitis c29.8SLC17A5, ITPA, ABCB7
15ulcerative colitis29.7HLA-G, GUSB, TPMT, BPI, ITPA
16neutropenia10.5
17reticular dysgenesis10.2
18lung cancer10.2
19arthritis10.2
20granulocytopenia10.2
21burns10.2
22crohn's disease10.2
23anorexia nervosa10.2
24systemic lupus erythematosus10.2
25gingivitis10.2
26hypertension10.2
27lupus erythematosus10.2
28propionic acidemia10.1
29felty's syndrome10.1
30breast cancer10.1
31dermatitis10.1
32lymphopenia10.1
33pneumonia10.1
34sepsis10.1
35pre-eclampsia10.1HLA-G
36wegener's granulomatosis10.1BPI, TPMT
37fascioliasis10.1SLC17A5
38cholangitis10.1SLC17A5
39sly syndrome10.1IDUA, GUSB
40gilbert syndrome10.1UGT1A1, TPMT
41mucopolysaccharidosis10.1IDUA, GUSB
42lysosomal storage disease10.0GUSB, IDUA
43neonatal jaundice10.0UGT1A1, GUSB
44cholelithiasis10.0GUSB, UGT1A1
45deficiency anemia10.0ITPA, TPMT, ABCB7
46sickle cell disease10.0GUSB, UGT1A1
47choledocholithiasis10.0SLC17A5, GUSB
48dengue disease10.0SLC17A5, ABCB7
49intrahepatic cholestasis10.0SLC17A5, HLA-G
50familial mediterranean fever10.0

Graphical network of the top 20 diseases related to Leukopenia:



Diseases related to leukopenia

Symptoms for Leukopenia

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Drugs & Therapeutics for Leukopenia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Leukopenia

Drug clinical trials:

Search ClinicalTrials for Leukopenia

Search NIH Clinical Center for Leukopenia

Search CenterWatch for Leukopenia

Genetic Tests for Leukopenia

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Anatomical Context for Leukopenia

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34MalaCards
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MalaCards organs/tissues related to Leukopenia:

34
Lung, Liver, Bone, Kidney, T cells, Bone marrow, Breast, Pancreas, Myeloid, Monocytes, Heart, Testes, Colon, Whole blood, Prostate

Animal Models for Leukopenia or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Leukopenia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.4ITPA, TPMT, GUSB, IDUA, HLA-G
2MP:00053787.6SLC17A5, ITPA, TPMT, GUSB, IDUA, ABCB7
3MP:00107687.3ABCB7, IDUA, GUSB, TPMT, ITPA, SLC17A5
4MP:00053767.3ABCB7, HLA-G, IDUA, GUSB, TPMT, SLC17A5

Publications for Leukopenia

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53PubMed
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Articles related to Leukopenia:

(show top 50)    (show all 503)
idTitleAuthorsYear
1
Effect of recombinant Ganoderma lucidum immunoregulatory protein on cyclophosphamide-induced leukopenia in mice. (23656432)
2013
2
G-CSF plus plerixafor (Mozobil) to mobilize hematopoietic stem cells in patients with thrombocytopenia or leukopenia prior to auto-SCT. (22773123)
2013
3
Sirolimus: a switch option for mycophenolate mofetil-induced leukopenia in renal transplant recipients. (24157014)
2013
4
Leukopenia as a risk factor for osteonecrosis of the jaw in metastatic prostate cancer treated using zoledronic acid and docetaxel. (22578070)
2012
5
Preterm neonates show marked leukopenia and lymphopenia that are associated with increased regulatory T-cell values and diminished IL-7. (22398700)
2012
6
Clozapine-induced late leukopenia. (20872253)
2012
7
Lamotrigine-associated thrombocytopenia and leukopenia. (20656445)
2012
8
Genetic determinants of mycophenolate-related anemia and leukopenia after transplantation. (21107304)
2011
9
Influence of granulocyte colony-stimulating factor on cardiac function in patients with acute myocardial infarction and leukopenia after revascularization. (20819563)
2010
10
Valganciclovir-induced leukopenia in liver transplant recipients: influence of concomitant use of mycophenolate mofetil. (19376423)
2009
11
Leukopenia due to parvovirus B19 in a Crohn's disease patient using azathioprine. (19390192)
2009
12
Cephalosporin-induced leukopenia following rechallenge with cefoxitin. (18648015)
2008
13
Cordyceps sinensis health supplement enhances recovery from taxol-induced leukopenia. (18367634)
2008
14
Incidence and temporal pattern of anorexia, diarrhea, weight loss, and leukopenia in patients with cervical cancer treated with concurrent radiation therapy and weekly cisplatin: comparison with radiation therapy alone. (16527337)
2006
15
Leukopenia due to anti-tuberculous chemotherapy including rifampicin and isoniazid]. (15211874)
2004
16
KF24345, an adenosine uptake inhibitor, suppresses lipopolysaccharide-induced tumor necrosis factor-alpha production and leukopenia via endogenous adenosine in mice. (11752117)
2002
17
Pathogenesis of pneumococcal pneumonia in cyclophosphamide-induced leukopenia in mice. (12117931)
2002
18
Venlafaxine in a patient with idiopathic leukopenia and mirtazapine-induced severe neutropenia. (12363126)
2002
19
Leukopenia and thrombocytopenia in pigs after infection with bovine viral diarrhoea virus-2 (BVDV-2). (12073495)
2002
20
Transient leukopenia and anaphylatoxin production during granulocyte apheresis as treatment for ulcerative colitis. (12378544)
2002
21
Initiation of clozapine therapy in a patient with preexisting leukopenia: a discussion of the rationale of current treatment options. (11958365)
2001
22
Monocyte deactivation and its reversal in a patient with chemotherapy-induced leukopenia and severe systemic infection. (10611583)
2000
23
Steroids may prevent leukopenia, interfering with response to IV azathioprine in treatment of Crohn's disease. (10866522)
2000
24
Results of hematologic analyses and prevalence of physiologic leukopenia in Belgian Tervuren. (22570897)
2000
25
Retrovirus-mediated gene transfer of the human multidrug resistance-associated protein into hematopoietic cells protects mice from chemotherapy-induced leukopenia. (10210147)
1999
26
Does chemotherapy-induced leukopenia predict a response in small-cell lung cancer? (9654193)
1998
27
Leukopenia prognosis during radiation therapy in patients with Hodgkin's disease. (9505215)
1997
28
Leukopenia prognosis by radiation therapy of patients with Hodgkin's disease. (9261745)
1997
29
Conditioning of cyclophosphamide-induced leukopenia in humans. (9081556)
1996
30
Granulocyte colony stimulating factor in the treatment of alcohol abuse, leukopenia, and pneumococcal sepsis. (7530862)
1995
31
Biologic effects and possible therapeutic use of the granulocyte-macrophage colony-stimulating factor. Modern treatment of leukopenia]. (7725160)
1993
32
Protective effect of ren-shen-yang-rong-tang (Ninjin-youei-to) in mice with drug-induced leukopenia against Pseudomonas aeruginosa infection. (1280629)
1992
33
Expression of a human multidrug resistance cDNA (MDR1) in the bone marrow of transgenic mice: resistance to daunomycin-induced leukopenia. (2573831)
1989
34
Chronic leukopenia associated with feline immunodeficiency virus infection in a cat. (2537275)
1989
35
A study on the mechanism of anemia and leukopenia in liver cirrhosis. (3418979)
1988
36
Changes in electrical charge of leukocyte surface membranes during hemodialysis. Possible role in transient leukopenia. (3196572)
1988
37
Benign familial leukopenia and neutropenia in different ethnic groups. (3181399)
1988
38
Typhoidal tularemia presenting as enteritis with leukopenia. (3176624)
1988
39
Long-term prophylaxis of infection by selective decontamination in leukopenia and in mechanical ventilation. (3296099)
1987
40
Serum lithium concentrations and peripheral leukocytes in a case of leukopenia. (3741920)
1986
41
Anaphylatoxin C5a generation and dialysis-induced leukopenia with different hemodialyzer membranes. (3730166)
1986
42
Leukopenia in Still's disease. (6481933)
1984
43
More on penicillin-induced leukopenia. (6835289)
1983
44
Isolated lateral rectus muscle palsy associated with leukopenia in two adults. (7137280)
1982
45
Lithium, biphasic granulocytosis and antiblastic leukopenia prevention. (6780428)
1980
46
Quinidine leukopenia and thrombocytopenia with a drug-dependent leukoagglutinin. (836544)
1977
47
Leukopenia in alcoholics. (4701945)
1973
48
Congenital lipomatosis of the pancreas. Malabsorption, dwarfism, leukopenia with relative granulocytopenia and thrombocytopenia. (5665293)
1968
49
Replacement transfusion therapy of thrombocytopenia and leukopenia. (5856194)
1964
50
Familial leukopenia-neutropenia in Yemenite Jews. Observations on eleven families. (13723164)
1961

Variations for Leukopenia

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Expression for genes affiliated with Leukopenia

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Leukopenia

Search GEO for disease gene expression data for Leukopenia.

Pathways for genes affiliated with Leukopenia

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51PathCards, 31KEGG, 39NCBI BioSystems Database, 52PharmGKB, 61Thomson Reuters, 56Reactome
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Pathways related to Leukopenia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
One Carbon Metabolism39
dTMP de novo biosynthesis (mitochondrial)39
tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate39
Trans-sulfuration and one carbon metabolism39
methionine salvage39
Methionine metabolism61
9.8ITPA, TPMT
2
Show member pathways
9.5GUSB, IDUA
3
Show member pathways
9.5GUSB, IDUA
4
Show member pathways
tetrapyrrole biosynthesis39
heme degradation39
Heme Biosynthesis39
heme biosynthesis39
heme biosynthesis from uroporphyrinogen-III I39
9.3GUSB, UGT1A1
58.7IDUA, GUSB, SLC17A5
6
Show member pathways
8.7ITPA, TPMT, GUSB, UGT1A1
7
Show member pathways
7.8ABCB7, UGT1A1, IDUA, GUSB, TPMT, ITPA

Compounds for genes affiliated with Leukopenia

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Sources:
52PharmGKB, 46Novoseek, 25HMDB, 12DrugBank, 30IUPHAR
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Compounds related to Leukopenia according to GeneCards/GeneDecks:

(show top 50)    (show all 141)
idCompoundScoreTop Affiliating Genes
1purine analogues5210.2TPMT, ITPA
2acetaminophen glucuronide46 2510.7GUSB, UGT1A1
3sn38 glucuronide469.7GUSB, UGT1A1
4morphine-3-glucuronide469.7UGT1A1, GUSB
54-methylumbelliferone469.7GUSB, UGT1A1
6udp glucuronic acid469.7UGT1A1, GUSB
7ethyl glucuronide46 2510.7UGT1A1, GUSB
8lamotrigine46 52 1211.7UGT1A1, GUSB
9glucuronide469.7GUSB, UGT1A1
10Dehydroepiandrosterone 3-glucuronide259.7GUSB, UGT1A1
11Cotinineglucuronide259.6UGT1A1, GUSB
12Inodxyl glucuronide259.6GUSB, UGT1A1
13thiopurine469.6UGT1A1, ITPA, TPMT
146 mercaptopurine469.6ITPA, UGT1A1, TPMT
15Isovalerylglucuronide259.6GUSB, UGT1A1
16Ketoprofen glucuronide259.6GUSB, UGT1A1
17Lithocholate 3-O-glucuronide259.6GUSB, UGT1A1
18Tyramine glucuronide259.6GUSB, UGT1A1
19Valproic acid glucuronide259.6GUSB, UGT1A1
20opium469.6SLC17A5, GUSB
21Vitamin D2 3-glucuronide259.6GUSB, UGT1A1
22beta-hydroxybutyrate469.5SLC17A5, ABCB7
23Cortolone-3-glucuronide259.5UGT1A1, GUSB
24bilirubin diglucuronide46 2510.5UGT1A1, GUSB
25lactulose469.5GUSB, SLC17A5
26glycocholate469.5GUSB, SLC17A5
27(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)259.5GUSB, UGT1A1
281-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid259.4GUSB, UGT1A1
292-Phenylethanol glucuronide259.4GUSB, UGT1A1
30irinotecan46 52 1211.4UGT1A1, GUSB, TPMT
31purine46 2510.4ITPA, TPMT, SLC17A5
3225-Hydroxyvitamin D2 25-(beta-glucuronide)259.3GUSB, UGT1A1
33Cholic acid glucuronide259.3GUSB, UGT1A1
3425-Hydroxyvitamin D2-25-glucuronide259.2GUSB, UGT1A1
353,17-Androstanediol glucuronide259.0GUSB, UGT1A1
36buprenorphine46 30 1210.9SLC17A5, UGT1A1, GUSB
37thyroxine46 259.9UGT1A1, ABCB7, SLC17A5
38phenobarbital46 30 52 1211.9UGT1A1, GUSB, SLC17A5
39morphine46 52 30 1211.9SLC17A5, UGT1A1, GUSB
40methotrexate52 46 1210.9TPMT, ITPA, SLC17A5, HLA-G
41magnesium46 25 1210.9ABCB7, SLC17A5, BPI, ITPA
42urea46 25 1210.8SLC17A5, BPI, HLA-G, ABCB7
43ethanol46 52 25 1211.7SLC17A5, BPI, GUSB, ABCB7
44silymarin468.5SLC17A5, UGT1A1, GUSB, ABCB7
45aspartate468.4UGT1A1, GUSB, ABCB7, SLC17A5
46heparin46 30 25 1211.3ABCB7, IDUA, GUSB, BPI, SLC17A5
47alanine468.3UGT1A1, ABCB7, TPMT, BPI, SLC17A5
48lactate468.2SLC17A5, BPI, GUSB, ABCB7, HLA-G
49cholesterol46 30 25 1211.1ABCB7, UGT1A1, HLA-G, BPI, SLC17A5
50creatinine467.9HLA-G, GUSB, SLC17A5, BPI, TPMT, ABCB7

GO Terms for genes affiliated with Leukopenia

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17Gene Ontology
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Cellular components related to Leukopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lysosomal lumenGO:0432029.5GUSB, IDUA

Biological processes related to Leukopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glycosaminoglycan catabolic processGO:0060279.5GUSB, IDUA
2small molecule metabolic processGO:0442817.5ITPA, TPMT, GUSB, IDUA, UGT1A1, ABCB7

Products for genes affiliated with Leukopenia

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Sources for Leukopenia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet