Summaries for Leukopenia

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Wikipedia:63 Leukopenia (also known as leukocytopenia or leucopenia, from Greek ?????? \"white\" and ?????... more...

MalaCards based summary: Leukopenia is related to inflammatory bowel disease and bacteremia. An important gene associated with Leukopenia is ITPA (inosine triphosphatase (nucleoside triphosphate pyrophosphatase)), and among its related pathways are One carbon pool by folate and Heparan sulfate/heparin (HS-GAG) metabolism. The compounds purine analogues and acetaminophen glucuronide have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and kidney, and related mouse phenotypes are hematopoietic system and growth/size/body.

Aliases & Classifications for Leukopenia

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Sources:
11DISEASES, 43Novoseek, 60UMLS
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Leukopenia, Aliases & Descriptions:

Name: Leukopenia 11 43 60


Related Diseases for Leukopenia

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Diseases related to Leukopenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 181)
idRelated DiseaseScoreTop Affiliating Genes
1inflammatory bowel disease30.6TPMT, ITPA
2bacteremia30.5GUSB, BPI
3thrombocytopenia30.5SLC17A5, TPMT, GUSB, IDUA, ABCB7
4hepatitis30.3SLC17A5, GUSB
5leukemia30.3IDUA, TPMT, GUSB, HLA-G
6acute leukemia30.2HLA-G, TPMT, IDUA
7vasculitis30.2TPMT, BPI
8pancreatitis30.2ITPA, SLC17A5, TPMT
9rheumatoid arthritis30.1GUSB, TPMT, BPI, HLA-G
10dengue disease30.1ABCB7, SLC17A5
11liver cirrhosis29.9ABCB7, SLC17A5, BPI
12alcohol abuse29.9ABCB7, SLC17A5
13hepatitis b29.8ABCB7, SLC17A5
14hepatitis c29.7ITPA, SLC17A5, ABCB7
15colorectal cancer29.4GUSB, TPMT, HLA-G, UGT1A1
16ulcerative colitis29.4HLA-G, ITPA, BPI, TPMT, GUSB
17neutropenia10.5
18reticular dysgenesis10.3
19pre-eclampsia10.3HLA-G
20wegener granulomatosis10.3TPMT, BPI
21fascioliasis10.3SLC17A5
22cholangitis10.3SLC17A5
23systemic lupus erythematosus10.3
24lung cancer10.3
25arthritis10.3
26granulocytopenia10.3
27mucopolysaccharidosis vii10.2IDUA, GUSB
28gilbert syndrome10.2UGT1A1, TPMT
29mucopolysaccharidosis10.2IDUA, GUSB
30crohn's disease10.2
31lupus erythematosus10.2
32gaucher's disease10.2IDUA, GUSB
33lysosomal storage disease10.2IDUA, GUSB
34anorexia nervosa10.2
35burns10.2
36gingivitis10.2
37pneumonia10.2
38neonatal jaundice10.1GUSB, UGT1A1
39deficiency anemia10.1TPMT, ABCB7, ITPA
40cholelithiasis10.1GUSB, UGT1A1
41breast cancer10.1
42camurati-engelmann disease10.1
43propionicacidemia10.1
44pulmonary hypertension10.1
45tick-borne encephalitis10.1
46felty's syndrome10.1
47dermatitis10.1
48encephalitis10.1
49lymphoblastic leukemia10.1
50lymphopenia10.1

Graphical network of the top 20 diseases related to Leukopenia:



Diseases related to leukopenia

Symptoms for Leukopenia

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Drugs & Therapeutics for Leukopenia

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Drug clinical trials:

Search ClinicalTrials for Leukopenia

Search NIH Clinical Center for Leukopenia

Genetic Tests for Leukopenia

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Anatomical Context for Leukopenia

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MalaCards organs/tissues related to Leukopenia:

31
Lung, Liver, Kidney, Bone, T cells, Breast, Neutrophil, Bone marrow, Pancreas, Testes, Myeloid, Heart, Monocytes, Whole blood, Spleen, Colon, Prostate

Animal Models for Leukopenia or affiliated genes

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MGI Mouse Phenotypes related to Leukopenia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.4ITPA, TPMT, GUSB, IDUA, HLA-G
2MP:00053787.6ABCB7, IDUA, GUSB, TPMT, ITPA, SLC17A5
3MP:00053767.3TPMT, GUSB, IDUA, HLA-G, ABCB7, SLC17A5
4MP:00107687.3SLC17A5, ITPA, TPMT, GUSB, IDUA, ABCB7

Publications for Leukopenia

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Articles related to Leukopenia:

(show top 50)    (show all 522)
idTitleAuthorsYear
1
Moxibustion for the treatment of chemotherapy-induced leukopenia: a systematic review of randomized clinical trials. (25471180)
2014
2
The effect of rhG-CSF on spleen transcriptome in mouse leukopenia model induced by cyclophosphamide. (24611752)
2014
3
Prognostic significance of leukopenia in childhood acute lymphoblastic leukemia. (24944687)
2014
4
Leukocyte count restoration under dabrafenib treatment in a melanoma patient with vemurafenib-induced leukopenia: case report. (25526431)
2014
5
Immunoproteomic to analysis the pathogenicity factors in leukopenia caused by Klebsiella pneumonia bacteremia. (25330314)
2014
6
Effect of recombinant Ganoderma lucidum immunoregulatory protein on cyclophosphamide-induced leukopenia in mice. (23656432)
2013
7
G-CSF plus plerixafor (Mozobil) to mobilize hematopoietic stem cells in patients with thrombocytopenia or leukopenia prior to auto-SCT. (22773123)
2013
8
Leukopenia as a risk factor for osteonecrosis of the jaw in metastatic prostate cancer treated using zoledronic acid and docetaxel. (22578070)
2012
9
Preterm neonates show marked leukopenia and lymphopenia that are associated with increased regulatory T-cell values and diminished IL-7. (22398700)
2012
10
Clozapine-induced late leukopenia. (20872253)
2012
11
Lamotrigine-associated thrombocytopenia and leukopenia. (20656445)
2012
12
Genetic determinants of mycophenolate-related anemia and leukopenia after transplantation. (21107304)
2011
13
Influence of granulocyte colony-stimulating factor on cardiac function in patients with acute myocardial infarction and leukopenia after revascularization. (20819563)
2010
14
Valganciclovir-induced leukopenia in liver transplant recipients: influence of concomitant use of mycophenolate mofetil. (19376423)
2009
15
Leukopenia due to parvovirus B19 in a Crohn's disease patient using azathioprine. (19390192)
2009
16
Cordyceps sinensis health supplement enhances recovery from taxol-induced leukopenia. (18367634)
2008
17
Incidence and temporal pattern of anorexia, diarrhea, weight loss, and leukopenia in patients with cervical cancer treated with concurrent radiation therapy and weekly cisplatin: comparison with radiation therapy alone. (16527337)
2006
18
Leukopenia due to anti-tuberculous chemotherapy including rifampicin and isoniazid]. (15211874)
2004
19
KF24345, an adenosine uptake inhibitor, suppresses lipopolysaccharide-induced tumor necrosis factor-alpha production and leukopenia via endogenous adenosine in mice. (11752117)
2002
20
Pathogenesis of pneumococcal pneumonia in cyclophosphamide-induced leukopenia in mice. (12117931)
2002
21
Venlafaxine in a patient with idiopathic leukopenia and mirtazapine-induced severe neutropenia. (12363126)
2002
22
Leukopenia and thrombocytopenia in pigs after infection with bovine viral diarrhoea virus-2 (BVDV-2). (12073495)
2002
23
Initiation of clozapine therapy in a patient with preexisting leukopenia: a discussion of the rationale of current treatment options. (11958365)
2001
24
Monocyte deactivation and its reversal in a patient with chemotherapy-induced leukopenia and severe systemic infection. (10611583)
2000
25
Steroids may prevent leukopenia, interfering with response to IV azathioprine in treatment of Crohn's disease. (10866522)
2000
26
Results of hematologic analyses and prevalence of physiologic leukopenia in Belgian Tervuren. (22570897)
2000
27
Retrovirus-mediated gene transfer of the human multidrug resistance-associated protein into hematopoietic cells protects mice from chemotherapy-induced leukopenia. (10210147)
1999
28
Does chemotherapy-induced leukopenia predict a response in small-cell lung cancer? (9654193)
1998
29
Leukopenia prognosis during radiation therapy in patients with Hodgkin's disease. (9505215)
1997
30
Leukopenia prognosis by radiation therapy of patients with Hodgkin's disease. (9261745)
1997
31
Conditioning of cyclophosphamide-induced leukopenia in humans. (9081556)
1996
32
Granulocyte colony stimulating factor in the treatment of alcohol abuse, leukopenia, and pneumococcal sepsis. (7530862)
1995
33
Protective effect of ren-shen-yang-rong-tang (Ninjin-youei-to) in mice with drug-induced leukopenia against Pseudomonas aeruginosa infection. (1280629)
1992
34
Expression of a human multidrug resistance cDNA (MDR1) in the bone marrow of transgenic mice: resistance to daunomycin-induced leukopenia. (2573831)
1989
35
Chronic leukopenia associated with feline immunodeficiency virus infection in a cat. (2537275)
1989
36
A study on the mechanism of anemia and leukopenia in liver cirrhosis. (3418979)
1988
37
Changes in electrical charge of leukocyte surface membranes during hemodialysis. Possible role in transient leukopenia. (3196572)
1988
38
Benign familial leukopenia and neutropenia in different ethnic groups. (3181399)
1988
39
Long-term prophylaxis of infection by selective decontamination in leukopenia and in mechanical ventilation. (3296099)
1987
40
Serum lithium concentrations and peripheral leukocytes in a case of leukopenia. (3741920)
1986
41
Anaphylatoxin C5a generation and dialysis-induced leukopenia with different hemodialyzer membranes. (3730166)
1986
42
Leukopenia in Still's disease. (6481933)
1984
43
More on penicillin-induced leukopenia. (6835289)
1983
44
Isolated lateral rectus muscle palsy associated with leukopenia in two adults. (7137280)
1982
45
Lithium, biphasic granulocytosis and antiblastic leukopenia prevention. (6780428)
1980
46
Quinidine leukopenia and thrombocytopenia with a drug-dependent leukoagglutinin. (836544)
1977
47
Leukopenia in alcoholics. (4701945)
1973
48
Congenital lipomatosis of the pancreas. Malabsorption, dwarfism, leukopenia with relative granulocytopenia and thrombocytopenia. (5665293)
1968
49
Replacement transfusion therapy of thrombocytopenia and leukopenia. (5856194)
1964
50
Familial leukopenia-neutropenia in Yemenite Jews. Observations on eleven families. (13723164)
1961

Variations for Leukopenia

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Expression for genes affiliated with Leukopenia

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Search GEO for disease gene expression data for Leukopenia.

Pathways for genes affiliated with Leukopenia

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Pathways related to Leukopenia according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
One Carbon Metabolism36
dTMP de novo biosynthesis (mitochondrial)36
tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate36
Trans-sulfuration and one carbon metabolism36
methionine salvage36
Methionine metabolism58
9.8ITPA, TPMT
2
Show member pathways
9.5GUSB, IDUA
3
Show member pathways
9.5GUSB, IDUA
4
Show member pathways
tetrapyrrole biosynthesis36
heme degradation36
Heme Biosynthesis36
heme biosynthesis36
heme biosynthesis from uroporphyrinogen-III I36
9.3GUSB, UGT1A1
58.7IDUA, GUSB, SLC17A5
6
Show member pathways
8.7ITPA, TPMT, GUSB, UGT1A1
7
Show member pathways
7.8ABCB7, UGT1A1, IDUA, GUSB, TPMT, ITPA

Compounds for genes affiliated with Leukopenia

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Sources:
49PharmGKB, 43Novoseek, 24HMDB, 12DrugBank, 28IUPHAR
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Compounds related to Leukopenia according to GeneCards Suite gene sharing:

(show top 50)    (show all 141)
idCompoundScoreTop Affiliating Genes
1purine analogues4910.2TPMT, ITPA
2acetaminophen glucuronide43 2410.7GUSB, UGT1A1
3sn38 glucuronide439.7GUSB, UGT1A1
4morphine-3-glucuronide439.7GUSB, UGT1A1
54-methylumbelliferone439.7UGT1A1, GUSB
6udp glucuronic acid439.7UGT1A1, GUSB
7ethyl glucuronide43 2410.7UGT1A1, GUSB
8lamotrigine43 49 1211.7GUSB, UGT1A1
9glucuronide439.7UGT1A1, GUSB
10Estrone glucuronide249.7UGT1A1, GUSB
11Estriol-3-glucuronide249.6UGT1A1, GUSB
12Estriol-17-glucuronide249.6UGT1A1, GUSB
13thiopurine439.6UGT1A1, ITPA, TPMT
146 mercaptopurine439.6ITPA, UGT1A1, TPMT
15Cholesterol glucuronide249.6UGT1A1, GUSB
16Etiocholanolone glucuronide249.6GUSB, UGT1A1
17Testosterone glucuronide249.6GUSB, UGT1A1
18Tetrahydroaldosterone-3-glucuronide249.6GUSB, UGT1A1
19Thyroxine glucuronide249.6GUSB, UGT1A1
20opium439.6SLC17A5, GUSB
21trans-3-Hydroxycotinine glucuronide249.6GUSB, UGT1A1
22beta-hydroxybutyrate439.5ABCB7, SLC17A5
23Cholestane-3,7,12,25-tetrol-3-glucuronide249.5UGT1A1, GUSB
2417-beta-estradiol glucuronide249.5UGT1A1, GUSB
25lactulose439.5SLC17A5, GUSB
26glycocholate439.5GUSB, SLC17A5
2717-beta-estradiol-3-glucuronide249.5GUSB, UGT1A1
2817-hydroxyandrostane-3-glucuronide249.4GUSB, UGT1A1
292-Methoxy-estradiol-17b 3-glucuronide249.4GUSB, UGT1A1
30irinotecan43 49 1211.4UGT1A1, GUSB, TPMT
31purine43 2410.4SLC17A5, ITPA, TPMT
322-Methoxyestrone 3-glucuronide249.3GUSB, UGT1A1
33Bilirubin glucuronide249.3GUSB, UGT1A1
346-Hydroxy-5-methoxyindole glucuronide249.2GUSB, UGT1A1
35Benzoyl glucuronide (Benzoic acid)249.0GUSB, UGT1A1
36buprenorphine43 28 1210.9SLC17A5, UGT1A1, GUSB
37thyroxine43 249.9ABCB7, UGT1A1, SLC17A5
38phenobarbital43 28 49 1211.9GUSB, SLC17A5, UGT1A1
39morphine43 49 28 1211.9SLC17A5, GUSB, UGT1A1
40methotrexate49 43 1210.9TPMT, ITPA, SLC17A5, HLA-G
41magnesium43 24 1210.9BPI, ABCB7, SLC17A5, ITPA
42urea43 24 1210.8SLC17A5, BPI, HLA-G, ABCB7
43ethanol43 49 24 1211.7GUSB, ABCB7, BPI, SLC17A5
44silymarin438.5SLC17A5, UGT1A1, GUSB, ABCB7
45aspartate438.4SLC17A5, UGT1A1, GUSB, ABCB7
46heparin43 28 24 1211.3ABCB7, IDUA, GUSB, BPI, SLC17A5
47alanine438.3UGT1A1, TPMT, ABCB7, SLC17A5, BPI
48lactate438.2SLC17A5, BPI, GUSB, ABCB7, HLA-G
49cholesterol43 28 24 1211.1ABCB7, SLC17A5, HLA-G, BPI, UGT1A1
50creatinine437.9HLA-G, GUSB, SLC17A5, BPI, TPMT, ABCB7

GO Terms for genes affiliated with Leukopenia

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Cellular components related to Leukopenia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1lysosomal lumenGO:00432029.5GUSB, IDUA

Biological processes related to Leukopenia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1glycosaminoglycan catabolic processGO:00060279.5GUSB, IDUA
2small molecule metabolic processGO:00442817.5ITPA, TPMT, GUSB, IDUA, UGT1A1, ABCB7

Products for genes affiliated with Leukopenia

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Sources for Leukopenia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet