MCID: LKP004
MIFTS: 46

Leukopenia malady

Summaries for Leukopenia

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64Wikipedia, 33MalaCards
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Wikipedia:64 Leukopenia (also known as leukocytopenia, or leucopenia, from Greek λευκό - white and πενία... more...

MalaCards: Leukopenia is related to thrombocytopenia and acute leukemia. An important gene associated with Leukopenia is ITPA (inosine triphosphatase (nucleoside triphosphate pyrophosphatase)), and among its related pathways are Ifosfamide Pathway, Pharmacokinetics and Gefitinib Pathway, Pharmacokinetics. The compounds 6 mercaptopurine and creatinine have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and heart, and related mouse phenotypes are integument and hematopoietic system.

Aliases & Classifications for Leukopenia

Sources:
10DISEASES, 45Novoseek, 61UMLS
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Aliases & Descriptions:

leukopenia 10 45 61


Related Diseases for Leukopenia

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Leukopenia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 224)
idRelated DiseaseScoreTop Affiliating Genes
1thrombocytopenia31.1IFNA2, IDUA, CSF2, CSF3, GUSB, TPMT
2acute leukemia30.4IDUA, CSF2, CSF3, TFRC, HLA-G, ITGAM
3arthritis30.3ITGAM, GUSB, CSF2
4sepsis30.2BPI, CSF2, CSF3, ITGAM, IL11, TMPO
5vasculitis30.1TPMT, ITGAM, IFNA2, BPI
6felty's syndrome30.1CSF2, CSF3
7aplastic anemia30.0CSF2, CSF3, TFRC, FLT3LG, CYP3A4, IL11
8tuberculosis30.0BPI, GUSB, ITGAM, TYMS, CYP3A4, IL11
9splenomegaly30.0IFNA2, CSF3, GPT, SLC17A5
10bacteremia30.0BPI, GUSB
11ulcerative colitis29.8BPI, GUSB, HLA-G, ITPA, IL11, TPMT
12deficiency anemia29.8CSF2, IFNA2, CSF3, TFRC, TPMT, TMPO
13acute myocardial infarction29.8TFRC, ITGAM, ABCB7
14atherosclerosis29.8ITGAM
15hepatitis c29.8IFNA2, GPT, ABCB7, SLC17A5
16alcohol abuse29.8GPT, ABCB7, SLC17A5
17septic shock29.8ITGAM, CSF3, BPI
18hepatitis d29.8GPT, IFNA2
19reticular dysgenesis10.2
20systemic lupus erythematosus10.2
21granulocytopenia10.2
22anorexia nervosa10.2
23propionic acidemia10.1
24crohn's disease10.0
25familial mediterranean fever10.0
26argentine hemorrhagic fever10.0
27tick-borne encephalitis10.0
28camurati-engelmann disease10.0
29acute myeloid leukemia10.0
30leukostasis10.0
31kaposi's sarcoma10.0
32typhoid fever10.0
33fumarate hydratase deficiency10.0
34toxic epidermal necrolysis10.0
35multiple myeloma10.0CSF3
36pancreatitis10.0ITPA, IL11, SLC17A5, TPMT
37thalassemia10.0UGT1A1, TFRC
38polycythemia10.0TFRC
39dermatitis10.0CSF2
40sickle cell disease10.0TFRC, GUSB, UGT1A1
41cystic fibrosis10.0ITGAM, GUSB, BPI
42sarcoma10.0GUSB, CYP3A4
43polycythemia vera10.0IFNA2
44herpes simplex10.0TMPO, FLT3LG
45diarrhea10.0UGT1A1, TYMS, CYP3A4
46diabetes mellitus10.0GPT, CYP3A4, ITGAM
47gingivitis10.0GUSB
48myocardial infarction10.0ITGAM, IL11, ABCB7
49autoimmune hepatitis10.0TPMT
50malaria10.0TFRC, TYMS

Graphical network of the top 20 diseases related to Leukopenia:



Diseases related to leukopenia

Clinical Features for Leukopenia

Drugs & Therapeutics for Leukopenia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Leukopenia

Drug clinical trials:

Search ClinicalTrials for Leukopenia

Search NIH Clinical Center for Leukopenia

Search CenterWatch for Leukopenia

Genetic Tests for Leukopenia

Anatomical Context for Leukopenia

Sources:
33MalaCards
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MalaCards organs/tissues related to Leukopenia:

33
Bone marrow, Whole blood, Heart, Small intestine, Colon, Kidney, Liver, Lung, Pancreas, Breast, Prostate, Myeloid, Monocytes, T cells, B lymphoblasts, B cells

Animal Models for Leukopenia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Leukopenia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001077110.5TMPO, GUSB, IDUA
2MP:000539710.3TPMT, IDUA, CSF2, CSF3, TFRC, GUSB
3MP:000538410.1GUSB, TFRC, CSF2, IDUA, ITGAM, ITPA

Publications for Leukopenia

Sources:
51PubMed
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Articles related to Leukopenia:

(show top 50)    (show all 510)
idTitleAuthorsYear
1
Effect of recombinant Ganoderma lucidum immunoregulatory protein on cyclophosphamide-induced leukopenia in mice. (23656432)
2013
2
Clozapine-induced late leukopenia. (20872253)
2012
3
Diagnostic value of leukopenia in young febrile infants. (21946037)
2012
4
Influences of thiopurine methyltransferase genotype and activity on thiopurine-induced leukopenia in Korean patients with inflammatory bowel disease: a retrospective cohort study. (20308917)
2010
5
Valganciclovir-induced leukopenia in liver transplant recipients: influence of concomitant use of mycophenolate mofetil. (19376423)
2009
6
Management of leukopenia in kidney and pancreas transplant recipients. (19040562)
2008
7
Late-onset hypersensitivity reaction with leukopenia and thrombocytopenia induced by oxcarbazepine treatment in a patient with schizoaffective disorder. (18507488)
2008
8
The usefulness of distal splenorenal shunt in children with portal hypertension for the treatment of severe thrombocytopenia and leukopenia. (18196322)
2008
9
The transfusion of neutrophil-specific antibodies causes leukopenia and a broad spectrum of pulmonary reactions. (17319838)
2007
10
The incidence of clozapine-induced leukopenia in patients with schizophrenia at Srinagarind Hospital. (18041439)
2007
11
The Pancreatitis Outcome Prediction (POP) score: how about hematocrit and leukopenia? (18075393)
2007
12
Correlation of residual leukocyte subsets with neutropenic fever during severe leukopenia after high-dose chemotherapy and autologous stem cell transplantation. (17050252)
2006
13
Systemic lupus erythematosus - associated acute severe thrombocytopenia and leukopenia first presented in pregnancy. (16260892)
2005
14
A rare cause of fever associated with leukopenia in a renal transplant patient. (15252176)
2004
15
Venlafaxine in a patient with idiopathic leukopenia and mirtazapine-induced severe neutropenia. (12363126)
2002
16
Quetiapine and leukopenia. (11329413)
2001
17
Hyponatremia and leukopenia associated with oxcarbazepine following carbamazepine therapy. (11556658)
2001
18
Severe leukopenia and liver necrosis in young African grey parrots (Psittacus erithacus erithacus) infected with psittacine circovirus. (10879931)
2000
19
Does chemotherapy-induced leukopenia predict a response in small-cell lung cancer? (9654193)
1998
20
Indirect-response model for the time course of leukopenia with anticancer drugs. (9834043)
1998
21
Fever, leukopenia, and thrombocytopenia in a patient with acute Lyme borreliosis were due to human granulocytic ehrlichiosis. (9455582)
1998
22
Leukopenia, thrombocytopenia, and Lyme borreliosis: is there an association? (9142830)
1997
23
Leukopenia and thrombocytopenia in a patient with early Lyme borreliosis. (8783732)
1996
24
The effect of granulocyte colony stimulating factor in patients with leukopenia due to sepsis. (7502498)
1995
25
Thrombocytopenia, leukopenia and abnormal liver function tests in the initial phase of tick-borne encephalitis. (7549159)
1995
26
High IL-6 serum levels are associated with septic shock and mortality in septic patients with severe leukopenia due to hematological malignancies. (8658074)
1995
27
Beta-Lactam antibiotic-induced leukopenia in severe hepatic dysfunction: risk factors and implications for dosing in patients with liver disease. (8452148)
1993
28
Trimethoprim/sulfamethoxazole-induced rash, fever, abnormal liver function tests, leukopenia, and thrombocytopenia. (8219452)
1993
29
Granulocyte-monocyte colony-stimulating factor levels during hemodialysis-induced leukopenia. (8290002)
1993
30
Species difference in susceptibility to phorbol myristate acetate-induced leukopenia and lung injury: rat vs. dog. (1474614)
1992
31
Reversible leukopenia related to ciprofloxacin therapy. (2188377)
1990
32
Leukopenia reduces microvascular clearance of macromolecules in ischemia-reperfusion injury. (2311428)
1990
33
Spurious automated leukopenia due to in vitro granulocyte aggregation. (2321589)
1990
34
Activation of the cytokine network by muroctasin as a remedy for leukopenia and thrombopenia. (2684174)
1989
35
Erythroblastopenia and leukopenia in the patient with severe herpes zoster treated with intravenous acyclovir. (2486432)
1989
36
Benign familial leukopenia and neutropenia in different ethnic groups. (3181399)
1988
37
Restorative effect of MDP-Lys (L18) on leukopenia of cancer patient treated with radiotherapy. (3231516)
1988
38
Toxic epidermal necrolysis. Granulocytic leukopenia as a prognostic indicator. (6372703)
1984
39
Cellulosic membrane induced leukopenia after reprocessing with sodium hypochlorite. (6533927)
1984
40
Leukopenia with different regenerated haemodialysis membranes. (6724830)
1984
41
Clinicopathological Conference. Neonate with jaundice and leukopenia. (6955946)
1982
42
Edema, proteinuria, thrombocytopenia, and leukopenia in infants of preeclamptic mothers. (7148908)
1982
43
Severe leukopenia and mild thrombocytopenia after chronic bromocriptine (CB-154) administration. (7246599)
1981
44
Cimetidine-induced leukopenia: case reports. (6779235)
1980
45
Leukopenia, hypoxia, and complement function with different hemodialysis membranes. (7230613)
1980
46
The effect of leukopenia versus thrombocytopenia on endotoxin induced intravascular coagulation. (1265711)
1976
47
Leukopenia after postmastectomy irradiation. (946294)
1976
48
Marked cyclic leukocytosis-leukopenia in chronic myelogenous leukemia. (1084692)
1976
49
Effect of induced leukopenia on the contraceptive action of an intrauterine device in the rat. (5561085)
1971
50
Counteraction of leukopenia caused by mechlorethamine and azathioprine. (4937567)
1971

Genetic Variations for Leukopenia

Expression for genes affiliated with Leukopenia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Leukopenia

Search GEO for disease gene expression data for Leukopenia.

Pathways for genes affiliated with Leukopenia

Sources:
50PharmGKB, 38NCBI BioSystems Database, 30KEGG, 54Reactome
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Compounds for genes affiliated with Leukopenia

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 60Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Leukopenia according to GeneCards/GeneDecks:

(show top 50)    (show all 225)
idCompoundScoreTop Affiliating Genes
16 mercaptopurine4510.9GPT, ITPA, UGT1A1, CSF3, TPMT
2creatinine4510.8TYMS, BPI, GUSB, HLA-G, ITGAM, GPT
3mycophenolate mofetil45 50 1112.8GPT, TPMT, CYP3A4, CSF3, UGT1A1, TFRC
4leucovorin45 50 1112.8TMPO, UGT1A1, TYMS, IFNA2, CSF2, CSF3
5filgrastim45 1111.8ITGAM, IL11, CSF2, IFNA2, CSF3
6ribavirin45 50 1112.8IFNA2, SLC17A5, GPT, ITPA, CSF3, CSF2
7lactate4510.8HLA-G, GUSB, TFRC, CSF2, TYMS, BPI
8prednisolone45 29 1112.8SLC17A5, GPT, CYP3A4, ITGAM, CSF3, TPMT
9ifosfamide45 1111.8IL11, CSF2, IFNA2, CYP3A4, TYMS, CSF3
10cytarabine45 50 1112.8TPMT, IL11, CYP3A4, TYMS, TFRC, CSF3
11neopterin4510.8IFNA2, CSF2, TFRC, HLA-G, GPT, SLC17A5
125fluorouracil4510.8TPMT, IFNA2, CSF2, CSF3, UGT1A1, TYMS
13irinotecan45 50 1112.8TYMS, TPMT, CYP3A4, UGT1A1, GUSB, CSF3
14silymarin4510.8GPT, ABCB7, SLC17A5, GUSB, UGT1A1
15cyclosporin a45 29 6012.8GPT, CSF2, TPMT, SLC17A5, IL11, CYP3A4
16purine45 2411.8TYMS, SLC17A5, TPMT, IFNA2, ITGAM, ITPA
17zidovudine45 1111.8TFRC, TMPO, IFNA2, GUSB, TYMS, CYP3A4
18ethanol45 50 11 2413.8GUSB, ITGAM, CYP3A4, IL11, GPT, BPI
19doxorubicin45 50 1112.8GUSB, CSF2, CSF3, TFRC, TYMS, CYP3A4
20dexamethasone45 50 29 1113.8ITGAM, CYP3A4, IDUA, UGT1A1
21cyclophosphamide45 50 1112.8TPMT, CSF2, IFNA2, IL11, CYP3A4, FLT3LG
22methotrexate45 50 1112.8GPT, HLA-G, TYMS, SLC17A5, ITPA, TPMT
23hydroxyurea45 50 1112.8TFRC, CSF3, TYMS, CSF2, UGT1A1, IFNA2
24pixy3214510.8CSF2, IL11, FLT3LG, CSF3
25aspartate4510.8GPT, ABCB7, IFNA2, TFRC, GUSB, UGT1A1
26mitoxantrone45 50 1112.8CSF2, IDUA, IFNA2, CSF3, CYP3A4
27thymidine45 2411.8FLT3LG, ITGAM, UGT1A1, TFRC, TYMS, CSF3
28heparin45 29 11 2413.8CSF2, ITGAM, GUSB, ABCB7, BPI, IL11
29methylcellulose4510.7FLT3LG, TFRC, CSF3, IL11, CSF2
30idarubicin45 50 1112.7IL11, CSF3, CSF2, IDUA
31vegf4510.7TYMS, FLT3LG, ITGAM, HLA-G, TFRC, CSF3
32etoposide45 50 60 1113.7TYMS, IL11, UGT1A1, CSF3, IFNA2, CYP3A4
33cisplatin45 50 60 1113.7SLC17A5, TFRC, TPMT, UGT1A1, TYMS, CSF3
34endotoxin4510.7BPI, SLC17A5, IL11, ITGAM, CSF3
35histamine45 29 2412.7TPMT, TFRC, IFNA2, GUSB, ITGAM, CSF2
36vitamin b124510.7TYMS, TFRC, GPT, SLC17A5, GUSB
37nevirapine45 50 1112.7GPT, ABCB7, SLC17A5
38daunorubicin45 50 1112.7GUSB, CSF3, IDUA, CSF2, CYP3A4
39thiopurine4510.7ITPA, TYMS, TPMT, UGT1A1
40alanine4510.7SLC17A5, TPMT, IFNA2, IL11, BPI, GPT
41tacrolimus45 50 1112.6CYP3A4, TFRC, TPMT, SLC17A5, IL11, GPT
42buprenorphine45 29 1112.6UGT1A1, SLC17A5, GUSB, CYP3A4
43dmso4510.6CSF3, CSF2, SLC17A5, TYMS, ITGAM, TFRC
44acetaminophen45 2 50 11 2414.6CYP3A4, GPT, UGT1A1, CSF2, SLC17A5
45pge14510.5IL11, TFRC, GUSB, GPT, SLC17A5
46carboplatin45 50 1112.5IL11, CSF3, CSF2, IFNA2, TYMS
47sn 3845 6011.4TYMS, CYP3A4, UGT1A1, GUSB
48tyrosine4510.4SLC17A5, TPMT, TMPO, IL11, FLT3LG, ITGAM
49phenobarbital45 29 1112.3GUSB, UGT1A1, CYP3A4, GPT, SLC17A5
50retinoic acid45 2411.1IL11, CYP3A4, ITGAM, BPI, IFNA2, CSF2

GO Terms for genes affiliated with Leukopenia

Sources:
16Gene Ontology
See all sources

Biological processes related to Leukopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heterocycle metabolic processGO:04648310.5CYP3A4, UGT1A1
2small molecule metabolic processGO:04428110.1TPMT, IDUA, GUSB, UGT1A1, ITPA, TYMS

Molecular functions related to Leukopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.4IL11, FLT3LG, CSF3, CSF2, IFNA2

Products for genes affiliated with Leukopenia

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Sources for Leukopenia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet