Aliases & Classifications for Leukopenia

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Sources:
10DISEASES, 44Novoseek, 61UMLS
See all sources

Aliases & Descriptions for Leukopenia:

Name: Leukopenia 10 44 61


Summaries for Leukopenia

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Wikipedia:64 Leukopenia (also known as leukocytopenia or leucopenia, from Greek ?????? \"white\" and ?????... more...

MalaCards based summary: Leukopenia is related to inflammatory bowel disease and bacteremia. An important gene associated with Leukopenia is ITPA (inosine triphosphatase (nucleoside triphosphate pyrophosphatase)), and among its related pathways are One carbon pool by folate and Heparan sulfate/heparin (HS-GAG) metabolism. The compounds purine analogues and acetaminophen glucuronide have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and kidney, and related mouse phenotypes are hematopoietic system and growth/size/body.

Related Diseases for Leukopenia

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Diseases related to Leukopenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 181)
idRelated DiseaseScoreTop Affiliating Genes
1inflammatory bowel disease30.6TPMT, ITPA
2bacteremia30.5GUSB, BPI
3thrombocytopenia30.5SLC17A5, TPMT, GUSB, IDUA, ABCB7
4hepatitis30.3SLC17A5, GUSB
5leukemia30.3IDUA, TPMT, GUSB, HLA-G
6acute leukemia30.2HLA-G, TPMT, IDUA
7vasculitis30.2TPMT, BPI
8pancreatitis30.2ITPA, SLC17A5, TPMT
9rheumatoid arthritis30.1GUSB, TPMT, BPI, HLA-G
10dengue disease30.1ABCB7, SLC17A5
11liver cirrhosis29.9ABCB7, SLC17A5, BPI
12alcohol abuse29.9ABCB7, SLC17A5
13hepatitis b29.8ABCB7, SLC17A5
14hepatitis c29.7ITPA, SLC17A5, ABCB7
15colorectal cancer29.4GUSB, TPMT, HLA-G, UGT1A1
16ulcerative colitis29.4HLA-G, ITPA, BPI, TPMT, GUSB
17neutropenia10.5
18reticular dysgenesis10.3
19pre-eclampsia10.3HLA-G
20wegener granulomatosis10.3TPMT, BPI
21fascioliasis10.3SLC17A5
22cholangitis10.3SLC17A5
23systemic lupus erythematosus10.3
24lung cancer10.3
25arthritis10.3
26granulocytopenia10.3
27mucopolysaccharidosis vii10.2IDUA, GUSB
28gilbert syndrome10.2UGT1A1, TPMT
29mucopolysaccharidosis10.2IDUA, GUSB
30crohn's disease10.2
31lupus erythematosus10.2
32gaucher's disease10.2IDUA, GUSB
33lysosomal storage disease10.2IDUA, GUSB
34anorexia nervosa10.2
35burns10.2
36gingivitis10.2
37pneumonia10.2
38neonatal jaundice10.1GUSB, UGT1A1
39deficiency anemia10.1TPMT, ABCB7, ITPA
40cholelithiasis10.1GUSB, UGT1A1
41breast cancer10.1
42camurati-engelmann disease10.1
43propionicacidemia10.1
44pulmonary hypertension10.1
45tick-borne encephalitis10.1
46felty's syndrome10.1
47dermatitis10.1
48encephalitis10.1
49lymphoblastic leukemia10.1
50lymphopenia10.1

Graphical network of the top 20 diseases related to Leukopenia:



Diseases related to leukopenia

Symptoms for Leukopenia

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Drugs & Therapeutics for Leukopenia

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Drug clinical trials:

Search ClinicalTrials for Leukopenia

Search NIH Clinical Center for Leukopenia

Genetic Tests for Leukopenia

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Anatomical Context for Leukopenia

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MalaCards organs/tissues related to Leukopenia:

31
Lung, Liver, Kidney, Bone, T cells, Breast, Neutrophil, Bone marrow, Pancreas, Testes, Myeloid, Heart, Monocytes, Whole blood, Spleen, Colon, Prostate

Animal Models for Leukopenia or affiliated genes

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MGI Mouse Phenotypes related to Leukopenia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.4ITPA, TPMT, GUSB, IDUA, HLA-G
2MP:00053787.6SLC17A5, ITPA, TPMT, GUSB, IDUA, ABCB7
3MP:00107687.3ABCB7, IDUA, GUSB, TPMT, ITPA, SLC17A5
4MP:00053767.3ABCB7, HLA-G, IDUA, GUSB, TPMT, SLC17A5

Publications for Leukopenia

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Articles related to Leukopenia:

(show top 50)    (show all 522)
idTitleAuthorsYear
1
Moxibustion for the treatment of chemotherapy-induced leukopenia: a systematic review of randomized clinical trials. (25471180)
2014
2
The effect of rhG-CSF on spleen transcriptome in mouse leukopenia model induced by cyclophosphamide. (24611752)
2014
3
Prognostic significance of leukopenia in childhood acute lymphoblastic leukemia. (24944687)
2014
4
Leukocyte count restoration under dabrafenib treatment in a melanoma patient with vemurafenib-induced leukopenia: case report. (25526431)
2014
5
Immunoproteomic to analysis the pathogenicity factors in leukopenia caused by Klebsiella pneumonia bacteremia. (25330314)
2014
6
Effect of recombinant Ganoderma lucidum immunoregulatory protein on cyclophosphamide-induced leukopenia in mice. (23656432)
2013
7
G-CSF plus plerixafor (Mozobil) to mobilize hematopoietic stem cells in patients with thrombocytopenia or leukopenia prior to auto-SCT. (22773123)
2013
8
Leukopenia as a risk factor for osteonecrosis of the jaw in metastatic prostate cancer treated using zoledronic acid and docetaxel. (22578070)
2012
9
Preterm neonates show marked leukopenia and lymphopenia that are associated with increased regulatory T-cell values and diminished IL-7. (22398700)
2012
10
Clozapine-induced late leukopenia. (20872253)
2012
11
Lamotrigine-associated thrombocytopenia and leukopenia. (20656445)
2012
12
Genetic determinants of mycophenolate-related anemia and leukopenia after transplantation. (21107304)
2011
13
Influence of granulocyte colony-stimulating factor on cardiac function in patients with acute myocardial infarction and leukopenia after revascularization. (20819563)
2010
14
Valganciclovir-induced leukopenia in liver transplant recipients: influence of concomitant use of mycophenolate mofetil. (19376423)
2009
15
Leukopenia due to parvovirus B19 in a Crohn's disease patient using azathioprine. (19390192)
2009
16
Cordyceps sinensis health supplement enhances recovery from taxol-induced leukopenia. (18367634)
2008
17
Incidence and temporal pattern of anorexia, diarrhea, weight loss, and leukopenia in patients with cervical cancer treated with concurrent radiation therapy and weekly cisplatin: comparison with radiation therapy alone. (16527337)
2006
18
Leukopenia due to anti-tuberculous chemotherapy including rifampicin and isoniazid]. (15211874)
2004
19
KF24345, an adenosine uptake inhibitor, suppresses lipopolysaccharide-induced tumor necrosis factor-alpha production and leukopenia via endogenous adenosine in mice. (11752117)
2002
20
Pathogenesis of pneumococcal pneumonia in cyclophosphamide-induced leukopenia in mice. (12117931)
2002
21
Venlafaxine in a patient with idiopathic leukopenia and mirtazapine-induced severe neutropenia. (12363126)
2002
22
Leukopenia and thrombocytopenia in pigs after infection with bovine viral diarrhoea virus-2 (BVDV-2). (12073495)
2002
23
Initiation of clozapine therapy in a patient with preexisting leukopenia: a discussion of the rationale of current treatment options. (11958365)
2001
24
Monocyte deactivation and its reversal in a patient with chemotherapy-induced leukopenia and severe systemic infection. (10611583)
2000
25
Steroids may prevent leukopenia, interfering with response to IV azathioprine in treatment of Crohn's disease. (10866522)
2000
26
Results of hematologic analyses and prevalence of physiologic leukopenia in Belgian Tervuren. (22570897)
2000
27
Retrovirus-mediated gene transfer of the human multidrug resistance-associated protein into hematopoietic cells protects mice from chemotherapy-induced leukopenia. (10210147)
1999
28
Does chemotherapy-induced leukopenia predict a response in small-cell lung cancer? (9654193)
1998
29
Leukopenia prognosis during radiation therapy in patients with Hodgkin's disease. (9505215)
1997
30
Leukopenia prognosis by radiation therapy of patients with Hodgkin's disease. (9261745)
1997
31
Conditioning of cyclophosphamide-induced leukopenia in humans. (9081556)
1996
32
Granulocyte colony stimulating factor in the treatment of alcohol abuse, leukopenia, and pneumococcal sepsis. (7530862)
1995
33
Protective effect of ren-shen-yang-rong-tang (Ninjin-youei-to) in mice with drug-induced leukopenia against Pseudomonas aeruginosa infection. (1280629)
1992
34
Expression of a human multidrug resistance cDNA (MDR1) in the bone marrow of transgenic mice: resistance to daunomycin-induced leukopenia. (2573831)
1989
35
Chronic leukopenia associated with feline immunodeficiency virus infection in a cat. (2537275)
1989
36
A study on the mechanism of anemia and leukopenia in liver cirrhosis. (3418979)
1988
37
Changes in electrical charge of leukocyte surface membranes during hemodialysis. Possible role in transient leukopenia. (3196572)
1988
38
Benign familial leukopenia and neutropenia in different ethnic groups. (3181399)
1988
39
Long-term prophylaxis of infection by selective decontamination in leukopenia and in mechanical ventilation. (3296099)
1987
40
Serum lithium concentrations and peripheral leukocytes in a case of leukopenia. (3741920)
1986
41
Anaphylatoxin C5a generation and dialysis-induced leukopenia with different hemodialyzer membranes. (3730166)
1986
42
Leukopenia in Still's disease. (6481933)
1984
43
More on penicillin-induced leukopenia. (6835289)
1983
44
Isolated lateral rectus muscle palsy associated with leukopenia in two adults. (7137280)
1982
45
Lithium, biphasic granulocytosis and antiblastic leukopenia prevention. (6780428)
1980
46
Quinidine leukopenia and thrombocytopenia with a drug-dependent leukoagglutinin. (836544)
1977
47
Leukopenia in alcoholics. (4701945)
1973
48
Congenital lipomatosis of the pancreas. Malabsorption, dwarfism, leukopenia with relative granulocytopenia and thrombocytopenia. (5665293)
1968
49
Replacement transfusion therapy of thrombocytopenia and leukopenia. (5856194)
1964
50
Familial leukopenia-neutropenia in Yemenite Jews. Observations on eleven families. (13723164)
1961

Variations for Leukopenia

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Expression for genes affiliated with Leukopenia

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Search GEO for disease gene expression data for Leukopenia.

Pathways for genes affiliated with Leukopenia

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Pathways related to Leukopenia according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
One Carbon Metabolism36
dTMP de novo biosynthesis (mitochondrial)36
tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate36
Trans-sulfuration and one carbon metabolism36
methionine salvage36
Methionine metabolism59
9.8ITPA, TPMT
2
Show member pathways
9.5GUSB, IDUA
3
Show member pathways
9.5GUSB, IDUA
4
Show member pathways
tetrapyrrole biosynthesis36
heme degradation36
Heme Biosynthesis36
heme biosynthesis36
heme biosynthesis from uroporphyrinogen-III I36
9.3GUSB, UGT1A1
58.7IDUA, GUSB, SLC17A5
6
Show member pathways
8.7ITPA, TPMT, GUSB, UGT1A1
7
Show member pathways
7.8ABCB7, UGT1A1, IDUA, GUSB, TPMT, ITPA

Compounds for genes affiliated with Leukopenia

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Sources:
50PharmGKB, 44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR
See all sources

Compounds related to Leukopenia according to GeneCards Suite gene sharing:

(show top 50)    (show all 141)
idCompoundScoreTop Affiliating Genes
1purine analogues5010.2TPMT, ITPA
2acetaminophen glucuronide44 2410.7GUSB, UGT1A1
3sn38 glucuronide449.7GUSB, UGT1A1
4morphine-3-glucuronide449.7UGT1A1, GUSB
54-methylumbelliferone449.7UGT1A1, GUSB
6udp glucuronic acid449.7GUSB, UGT1A1
7ethyl glucuronide44 2410.7GUSB, UGT1A1
8lamotrigine44 50 1111.7GUSB, UGT1A1
9glucuronide449.7UGT1A1, GUSB
10Dehydroisoandrosterone 3-glucuronide249.7UGT1A1, GUSB
11Deoxycholic acid 3-glucuronide249.6UGT1A1, GUSB
12Dehydroepiandrosterone 3-glucuronide249.6UGT1A1, GUSB
13thiopurine449.6UGT1A1, ITPA, TPMT
146 mercaptopurine449.6ITPA, UGT1A1, TPMT
15Palmitoyl glucuronide249.6UGT1A1, GUSB
163-Methoxy-4-hydroxyphenylglycol glucuronide249.6UGT1A1, GUSB
17Dextrorphan O-glucuronide249.6GUSB, UGT1A1
18Lithocholate 3-O-glucuronide249.6GUSB, UGT1A1
19Nicotine glucuronide249.6GUSB, UGT1A1
20opium449.6SLC17A5, GUSB
21Octanoylglucuronide249.6GUSB, UGT1A1
22beta-hydroxybutyrate449.5SLC17A5, ABCB7
233-alpha-hydroxy-5-alpha-androstane-17-one 3-D-glucuronide249.5UGT1A1, GUSB
24flunitrazepam28 44 1111.5UGT1A1, GUSB
25lactulose449.5SLC17A5, GUSB
26glycocholate449.5SLC17A5, GUSB
271-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid249.5GUSB, UGT1A1
281-Salicylate glucuronide249.4GUSB, UGT1A1
2911-beta-hydroxyandrosterone-3-glucuronide249.4GUSB, UGT1A1
30irinotecan44 50 1111.4UGT1A1, GUSB, TPMT
31purine44 2410.4ITPA, TPMT, SLC17A5
3211-Hydroxyprogesterone 11-glucuronide249.3GUSB, UGT1A1
333-alpha,20-alpha-dihydroxy-5-beta-pregnane 3-glucuronide249.3GUSB, UGT1A1
3411-Oxo-androsterone glucuronide249.2GUSB, UGT1A1
353,17-Androstanediol glucuronide249.0GUSB, UGT1A1
36buprenorphine44 28 1110.9SLC17A5, UGT1A1, GUSB
37thyroxine44 249.9ABCB7, SLC17A5, UGT1A1
38phenobarbital44 28 50 1111.9UGT1A1, GUSB, SLC17A5
39morphine44 50 28 1111.9UGT1A1, SLC17A5, GUSB
40methotrexate50 44 1110.9TPMT, ITPA, SLC17A5, HLA-G
41magnesium44 24 1110.9SLC17A5, BPI, ITPA, ABCB7
42urea44 24 1110.8SLC17A5, BPI, HLA-G, ABCB7
43ethanol44 50 24 1111.7SLC17A5, BPI, GUSB, ABCB7
44silymarin448.5SLC17A5, UGT1A1, GUSB, ABCB7
45aspartate448.4ABCB7, SLC17A5, GUSB, UGT1A1
46heparin44 28 24 1111.3ABCB7, IDUA, GUSB, BPI, SLC17A5
47alanine448.3UGT1A1, ABCB7, TPMT, BPI, SLC17A5
48lactate448.2SLC17A5, BPI, GUSB, ABCB7, HLA-G
49cholesterol44 28 24 1111.1ABCB7, UGT1A1, HLA-G, BPI, SLC17A5
50creatinine447.9HLA-G, GUSB, SLC17A5, BPI, TPMT, ABCB7

GO Terms for genes affiliated with Leukopenia

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Cellular components related to Leukopenia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1lysosomal lumenGO:00432029.5GUSB, IDUA

Biological processes related to Leukopenia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1glycosaminoglycan catabolic processGO:00060279.5GUSB, IDUA
2small molecule metabolic processGO:00442817.5ITPA, TPMT, GUSB, IDUA, UGT1A1, ABCB7

Sources for Leukopenia

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet