Leukopenia malady

Wikipedia: Leukopenia (also known as leukocytopenia, or leucopenia, from Greek λευκό - white and πενία...⁴⁴ more...

MalaCards: Leukopenia is related to felty's syndrome and hepatitis. An important gene associated with Leukopenia is ITPA (inosine triphosphatase (nucleoside triphosphate pyrophosphatase)), and among its related pathways are Drug metabolism - other enzymes and Primary immunodeficiency. The compounds vincristine and pge2 have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and breast, and related mouse phenotypes are renal/urinary system and respiratory system.

leukopenia 8 32 43

Diseases related to leukopenia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 826)

id	Related Disease	Score	Top Affiliating Genes
1	felty's syndrome	30.3	IL3, CSF2, CSF3
2	hepatitis	28.7	GPT, IFNA1, SLC17A5
3	hepatitis b	27.4	IL17A, GPT, IFNA1, IFNA2, IFNG, ALB
4	typhoid fever	26.8	CD79A, IL1B, GPT, IFNG, TNF, CRP
5	toxoplasmosis	25.3	CD79A, CD4, IL17A, IL1B, IFNG, TNF
6	anorexia nervosa	24.9	UGT1A1, IL1B, IL6, GPT, IGF1, IFNG
7	crohn's disease	24.2	BPI, MPO, IL11, IL17A, IL1B, IL6
8	lymphopenia	24.0	SELL, RAG2, RAG1, LCK, CD4, CD52
9	septic shock	23.9	SELL, SERPINC1, BPI, ITGAM, IL1B, IL6
10	breast cancer	23.4	BRCA2, BRIP1, LIG4, PALB2, GSTM1, GSTT1
11	sepsis	23.2	SELL, SERPINC1, BPI, MPO, ITGAL, ITGAM
12	kaposi's sarcoma	23.0	UGT1A1, CD4, ITGB2, IL16, IL1B, IL3
13	neutropenia	21.0	UGT1A1, MPO, CD79A, ITGAL, ITGAM, GUSB
14	vasculitis	19.6	SELL, SERPINC1, BPI, MPO, CD79A, CD4
15	thrombocytopenia	18.9	NCAM1, KIAA0101, SELL, SERPINC1, FTH1, FTL
16	acute leukemia	18.3	NCAM1, SELL, SERPINC1, RAG1, MPO, CD79A
17	sarcoma	16.9	NCAM1, SERPINC1, BRCA2, LIG4, UGT1A1, LCK
18	dyserythropoietic anemia with thrombocytopenia	14.0	IL11, IL3, IFNA1, TPMT, CSF2, CSF3
19	essential thrombocythemia	13.9	IL11, IL3, IFNA1, IFNA2
20	gilbert syndrome	13.9	UGT1A1, TPMT, DPYD
21	cyclic hematopoiesis	13.9	IL3, ELANE, CSF2, CSF3
22	artemis deficiency	13.8	RAG2, RAG1, DCLRE1C
23	severe congenital neutropenia	13.8	IL3, ELANE, CSF2, CSF3
24	21-hydroxylase deficiency	13.8	GUSB, GPT, IFNA1, IFNA2, ALPP, ABCB7
25	hemolytic anemia	13.8	UGT1A1, IFNA2, F3, TFRC, ADA
26	dna ligase iv deficiency	13.8	LIG4, DCLRE1C, NHEJ1
27	5-fluorouracil toxicity	13.8	UGT1A1, ABCB1, TYMS, DPYD
28	severe combined immunodeficiency, t cell-negative, b-cell/natural killer-cell positive	13.8	CD3D, IL7R, PTPRC
29	common bile duct disease	13.7	ALPL, ALPP, ALPPL2
30	osteitis fibrosa	13.7	IL11, ALPL, ALPP, ALPPL2
31	osteosclerosis	13.7	IL11, IFNA2, ALPL, ALPP, ALPPL2
32	nutritional deficiency disease	13.7	FTH1, FTL, TFRC
33	fanconi anemia, complementation group b	13.7	FANCD2, FANCL, FANCE, FANCF, FANCC, FANCG
34	splenomegaly	13.7	CD5, ITGB2, GPT, IFNA1, IFNA2, TYMS
35	acute megakaryoblastic leukemia	13.7	MPO, IL11, IL3, CSF2
36	hypersplenism	13.7	IL11, ALB, CSF2, CSF3
37	myeloproliferative disorder	13.6	MPO, IL11, IL3, IFNA1, IFNA2, CSF2
38	chronic myelomonocytic leukemia	13.6	MPO, TOP1, CSF2, CSF3
39	fanconi anemia, complementation group m	13.6	FANCD2, FANCL, FANCE, FANCF, FANCC, FANCG
40	autoimmune hepatitis	13.6	UGT1A1, GSTT1, GPT, IFNA1, TPMT, PTPRC
41	leukemoid reaction	13.6	IL3, CRP, CSF2, CSF3
42	galactosemia	13.6	GPT, F3, ALB, CYP3A4, ABCB7, SLC17A5
43	siderosis	13.6	FTH1, GPT, IGF1, TFRC
44	cholelithiasis	13.6	UGT1A1, CD79A, GUSB, GPT, SLC17A5
45	leukemia, acute nonlymphocytic	13.6	IL3, ABCB1, ABCC1, TYMS
46	extrahepatic cholestasis	13.6	ALPP, ABCC1, ABCC2
47	neonatal jaundice	13.5	UGT1A1, GUSB, NR1I3
48	skin carcinoma	13.5	GSTM1, GSTT1, CSF2, CSF3
49	intrahepatic cholestasis of pregnancy	13.5	GPT, HLA-G, CYP3A4, NR1I2, ABCB7, ABCC1
50	testicular germ cell cancer	13.5	ALPP, CYP3A4, CYP3A5, ABCB1, CSF3

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to leukopenia:

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MGI Mouse Phenotypes related to leukopenia:

²⁵ (show all 18)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	renal/urinary system phenotype	MP:0005367	10.1	ABCC2, IDUA, RAG1, PTPRC
2	respiratory system phenotype	MP:0005388	9.4	RAG2, ITPA, RAG1, ADA, SELL, PTPRC
3	integument phenotype	MP:0010771	9.0	TMPO, ITPA, CD19, CSF2, CD4, RAG1
4	nervous system phenotype	MP:0003631	9.0	SLC17A5, SERPINC1, IDUA, ITGAM, CD19, CD4
5	digestive/alimentary phenotype	MP:0005381	8.9	LIG4, TFRC, PTPRC, TMPO, ALPL, IFNG
6	hematopoietic system phenotype	MP:0005397	8.8	KIAA0101, BRCA2, RAG2, RAG1, ADA, C5AR1
7	endocrine/exocrine gland phenotype	MP:0005379	8.7	FANCG, SELL, BRCA2, RAD51C, FANCM, IFNG
8	skeleton phenotype	MP:0005390	8.5	IL6, IL17A, ITGB2, RAG2, BRCA2, FANCC
9	growth/size phenotype	MP:0005378	7.9	GUSB, IL2, IL6, FANCD2, FANCL, ITPA
10	liver/biliary system phenotype	MP:0005370	7.8	IFNG, IDUA, PTPRC, NR1I2, NR1I3, ABCB1
11	reproductive system phenotype	MP:0005389	7.8	FANCL, FANCD2, IL6, IL2RG, GUSB, LIG4
12	normal phenotype	MP:0002873	7.0	ADA, CD5, CD4, ELANE, ALPP, CD52
13	tumorigenesis	MP:0002006	6.5	FANCD2, IL3, FANCM, IGF1, IFNG, TNF
14	mortality/aging	MP:0010768	5.9	ADA, C5AR1, SLCO1B3, SLX4, SLC17A5, CSF2
15	immune system phenotype	MP:0005387	5.9	ELANE, TFRC, DCLRE1C, CSF2, SLX4, NHEJ1
16	cardiovascular system phenotype	MP:0005385	5.1	ALPL, F3, IDUA, IFNG, IGF1, IL6
17	homeostasis/metabolism phenotype	MP:0005376	4.3	SLX4, SLC17A5, CSF2, TFRC, ELANE, ABCC2
18	cellular phenotype	MP:0005384	4.1	NCAM1, KIAA0101, SELL, BRCA2, RAG2, IFNG

Articles related to leukopenia:

(show all 30)

id	Title	Authors	Year	Affiliating Genes
1	Evaluating glutathione S-transferase (GST) null genot ypes (GSTT1 and GSTM1) as a potential biomarker of predisposition for developin g leukopenia. (19555437)	Goncalves M.S.... Reis M.G.	2010	GSTT1, GSTM1
2	Influences of Thiopurine Methyltransferase Genotype a nd Activity on Thiopurine-induced Leukopenia in Korean Patients With Inflammato ry Bowel Disease: A Retrospective Cohort Study. (20308917)	Kim J.H.... Kim W.H.	2010	ITPA, TPMT
3	Leukopenia due to parvovirus B19 in a Crohn's disease patient using azathioprine. (19390192)	van Asseldonk D.P.... van Bodegraven A.A.	2009	TPMT
4	Association of genetic polymorphisms in SLCO1B3 and ABCC2 with docetaxel-induced leukopenia. (18294295)	Kiyotani K.... Nakamura Y.	2008	CYP3A4, CYP3A5, ABCB1
5	Low insulin-like growth factor I and leukopenia in anorexia nervosa. (18213689)	Polli N.... Cavagnini F.	2008	IGF1
6	Leukopenia complicates cytomegalovirus prevention after renal transplantation with alemtuzumab induction. (17460557)	Walker J.K.... Leventhal J.R.	2007	CSF3
7	Leukopenia due to anti-tuberculous chemotherapy including rifampicin and isoniazid (15211874)	Nagayama N.... Yotsumoto H.	2004	GPT, SLC17A5
8	Responsiveness to G-CSF before leukopenia predicts defense to infection in high-dose chemotherapy recipients. (15205265)	Straka C.... Emmerich B.	2004	CSF3
9	Leukopenia and thrombocytopenia in hemodialysis patients with hepatitis B or C virus infection and non-hemodialysis patients with hepatitis cirrhosis. (12005245)	Ng Y.Y.... Lee S.D.	2002	ALB, SLC17A5
10	Effect of G-CSF (nartograstim) on neutropenia (leukopenia) induced by taxane in metastatic breast cancer--time-course changes in neutrophil and leukocyte counts (11432350)	Kinoshita J.... Kajiwara T.	2001	CSF3
11	Initiation of clozapine therapy in a patient with pre existing leukopenia: a discussion of the rationale of current treatment options . (11958365)	Boshes R.A.... Hanrahan-Boshes M.	2001	CSF3
12	The cellular immune system of patients with acute leukemia and severe chemotherapy-induced leukopenia: characterization of T lymphocyte subsets responsive to IL-16 and IL-17. (11154979)	Bruserud O.... Ulvestad E.	2000	IL16, IL17A
13	Retrovirus-mediated gene transfer of the human multid rug resistance-associated protein into hematopoietic cells protects mice from c hemotherapy-induced leukopenia. (10210147)	Machiels J.P.... D'Hondt V.	1999	ABCC1
14	Criteria of systemic inflammatory response syndrome are unacceptable in the diagnosis of sepsis in patients with leukopenia (10050344)	Galstian G.M.... Danilina A.V.	1998	SERPINC1
15	Granulocyte colony-stimulating factor for gastrointestinal perforation in patients with leukopenia. (8614070)	Nishida T.... Fujita N.	1996	CSF3
16	Effect of timing of granulocyte-colony stimulating factor administration on leukopenia induced by systemic chemotherapy in patients with non-small-cell lung cancer--multi-center randomized crossover study (8753109)	Katakami N.... Nakai H.	1996	CSF3
17	Ritodrine-induced leukopenia: a case report and literature review. (9041773)	Wu C.D.... Soong Y.K.	1996	ADRB2
18	Leukopenia and rheological anomalies in leukocytes during hemodialysis in patients with chronic renal failure. (8938681)	Iijima S.... Kikuchi Y.	1996	ELANE
19	Comparison of two strategies for the treatment of radiogenic leukopenia using granulocyte colony stimulating factor. (8641928)	Adamietz I.A.... Boettcher H.D.	1996	CSF3
20	The effect of granulocyte colony stimulating factor in patients with leukopenia due to sepsis. (7502498)	Bittner E.W.... Chendrasekhar A.	1995	CSF3
21	Vasculitis complicating granulocyte colony stimulating factor treatment of leukopenia and infection in Felty's syndrome. (7545756)	Farhey Y.D.... Herman J.H.	1995	CSF3
22	Treatment of leukopenia with granulocyte-macrophage colony-stimulating factor after heart transplantation. (7482859)	Wasler A.... Tscheliessnigg K.H.	1995	CSF2
23	High IL-6 serum levels are associated with septic shock and mortality in septic patients with severe leukopenia due to hematological malignancies. (8658074)	Antonelli M.... Gasparetto A.	1995	TNF, IL6
24	Serum concentrations of tumour necrosis factor-alpha during chemotherapy-induced leukopenia in patients with acute leukaemia and bacterial infections. (8207959)	Bruserud O.... Nesthus I.	1994	TNF
25	Effect of granulocyte colony stimulating factor (G-CSF) on peripheral blood leukocytes and lymphocytes in patients with chemotherapy-induced leukopenia (7531660)	BAPhme M.... Weise W.	1994	CSF3
26	CD4+ T cell-mediated leukopenia of Felty's syndrome successfully treated with granulocyte-colony-stimulating factor and methotrexate. (7510488)	Hoshina Y.... Ichikawa Y.	1994	CSF3
27	Biologic effects and possible therapeutic use of the granulocyte-macrophage colony-stimulating factor. Modern treatment of leukopenia (7725160)	JovanoviA8-MiA8iA8 D.... Bosnjak S.	1993	CSF2
28	Case report: reversal of severe leukopenia by granulocyte colony-stimulating factor in anorexia nervosa. (7683451)	Fukudo S.... Hoshino A.	1993	CSF3
29	Granulocyte colony stimulating factor (G-CSF) in treatment of patients with HIV-associated mucocutaneous Kaposi sarcoma. Successful use in virus and drug-induced leukopenia (1281810)	SchrAPder K.... Orfanos C.E.	1992	CSF3, IFNA2
30	Effect of human granulocyte colony stimulating factor (G-CSF) and reduced glutathione (GSH) on drug-induced leukopenia in golden Syrian hamsters. (1704624)	Citarrella P.... Rausa L.	1990	CSF3

Genes related to leukopenia according to GeneCards:

(show top 50)    (show all 95)

id	Symbol	Description	Score	GeneCards Section Context
1	ITPA	inosine triphosphatase (nucleoside triphosphate pyrophosphatase)	11.0	Publications
2	TPMT	thiopurine S-methyltransferase	11.0	Publications
3	IDUA	iduronidase, alpha-L-	11.0
4	FLT3LG	fms-related tyrosine kinase 3 ligand	11.0
5	BPI	bactericidal/permeability-increasing protein	11.0
6	TMPO	thymopoietin	11.0
7	IL11	interleukin 11	11.0
8	ABCB7	ATP-binding cassette, sub-family B (MDR/TAP), member 7	11.0
9	CSF3	colony stimulating factor 3 (granulocyte)	11.0	Publications
10	TFRC	transferrin receptor (p90, CD71)	11.0
11	GUSB	glucuronidase, beta	11.0
12	HLA-G	major histocompatibility complex, class I, G	11.0
13	CSF2	colony stimulating factor 2 (granulocyte-macrophage)	11.0	Publications
14	SLC17A5	solute carrier family 17 (anion/sugar transporter), member 5	11.0	Publications
15	UGT1A1	UDP glucuronosyltransferase 1 family, polypeptide A1	11.0
16	ITGAM	integrin, alpha M (complement component 3 receptor 3 subunit)	11.0
17	CYP3A4	cytochrome P450, family 3, subfamily A, polypeptide 4	11.0	Publications
18	F3	coagulation factor III (thromboplastin, tissue factor)	11.0
19	GPT	glutamic-pyruvate transaminase (alanine aminotransferase)	11.0	Publications
20	IL3	interleukin 3 (colony-stimulating factor, multiple)	11.0
21	DPYD	dihydropyrimidine dehydrogenase	11.0
22	TOP1	topoisomerase (DNA) I	11.0
23	IFNA2	interferon, alpha 2	11.0	Publications
24	TYMS	thymidylate synthetase	11.0
25	IFNA1	interferon, alpha 1	11.0
26	FANCE	Fanconi anemia, complementation group E	11.0
27	FANCB	Fanconi anemia, complementation group B	11.0
28	FANCF	Fanconi anemia, complementation group F	11.0
29	CD52	CD52 molecule	11.0
30	C1GALT1C1	C1GALT1-specific chaperone 1	11.0
31	KIAA0101	KIAA0101	11.0
32	RAD51C	RAD51 homolog C (S. cerevisiae)	11.0
33	RAG2	recombination activating gene 2	11.0
34	FANCG	Fanconi anemia, complementation group G	11.0
35	CD3D	CD3d molecule, delta (CD3-TCR complex)	11.0
36	NHEJ1	nonhomologous end-joining factor 1	11.0
37	GOT1	glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)	11.0
38	PALB2	partner and localizer of BRCA2	11.0
39	IL2RG	interleukin 2 receptor, gamma	11.0
40	RAG1	recombination activating gene 1	11.0
41	FANCM	Fanconi anemia, complementation group M	11.0
42	SLX4	SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)	11.0
43	TXNL1	thioredoxin-like 1	11.0
44	LIG4	ligase IV, DNA, ATP-dependent	11.0
45	ALPPL2	alkaline phosphatase, placental-like 2	11.0
46	GOT2	glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)	11.0
47	FANCL	Fanconi anemia, complementation group L	11.0
48	CD5	CD5 molecule	11.0
49	DCLRE1C	DNA cross-link repair 1C	11.0
50	CD19	CD19 molecule	11.0

Pathways related to leukopenia according to GeneDecks:

(show top 50)    (show all 95)

id	Pathway	Score	Top Affiliating Genes
1	Drug metabolism - other enzymes20	10.6	GUSB, DPYD, UGT1A1, TPMT, ITPA, CYP3A5
2	Primary immunodeficiency20	10.4	RAG2, CD3D, CD4, IL2RG, DCLRE1C
3	IL-6 Pathway36	10.4	IL11, IL16, IL3, CSF2, CSF3
4	Carbamazepine Pathway, Pharmacokinetics34	10.4	CYP3A4, ABCC2, NR1I3, CYP3A5, NR1I2
5	Vinka Alkaloid Pathway, Pharmacokinetics34	10.4	ABCC2, ABCC1, CYP3A5, CYP3A4
6	Fanconis Anaemia Pathway36	10.3	FANCD2, FANCL, FANCE, FANCF, FANCG, BRCA2
7	Fanconi Anemia pathway38	10.2	FANCD2, FANCG, FANCC, FANCI, FANCF, FANCE
8	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.2	CD3D, IL2, IL2RG, CSF2
9	Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics34	10.2	UGT1A1, SLCO1B3, CYP3A5, ABCC2, ABCB1, CYP3A4
10	Graft-versus-host disease20	10.2	IL2, HLA-G
11	Statin Pathway - Generalized, Pharmacokinetics34	10.2	SLCO1B3, ABCC2, ABCB1, CYP3A4, UGT1A1, CYP3A5
12	BRCA1 Pathway36	10.2	FANCD2, FANCL, FANCG, FANCE, FANCF, FANCC
13	Jak-STAT signaling pathway20	10.1	IL3, IL2RG, IL2, IL11, IFNA1, IL7R
14	Mycophenolic acid Pathway, Pharmacokinetics34	10.1	SLCO1B3, ABCB1, CYP3A5, CYP3A4, ABCC2
15	Irinotecan Pathway, Pharmacokinetics34	10.1	ABCC2, UGT1A1, CYP3A4, ABCC1, ABCB1, CYP3A5
16	RAR-Gamma-RXR-Alpha Degradation36	10.1	IL11, CSF3, CSF2, IL3, IL2, IL16
17	Erlotinib Pathway, Pharmacokinetics34	9.9	UGT1A1, CYP3A4, CYP3A5, ABCB1
18	Taxane Pathway, Pharmacokinetics34	9.9	ABCC1, ABCB1, NR1I2, CYP3A5, CYP3A4, ABCC2
19	NFAT Signaling and Lymphocyte Interactions36	9.8	CD3D, CD4, IL11, IL16, IL2, IL2RG
20	DNA Repair Mechanisms36	9.8	FANCD2, FANCE, FANCF, FANCC, FANCG, BRCA2
21	Codeine and Morphine Pathway, Pharmacokinetics34	9.7	ABCB1, UGT1A1, ABCC2, CYP3A4
22	Lymphocyte Signaling3	9.7	RAG1, CD19, CD4, LCK, NCAM1
23	Etoposide Pathway, Pharmacokinetics/Pharmacodynamics34	9.6	UGT1A1, MPO, GSTT1, CYP3A4, NR1I2, ABCB1
24	Cell adhesion molecules (CAMs)20	9.3	ITGB2, CD4, SELL, NCAM1, HLA-G, PTPRC
25	Natural killer cell mediated cytotoxicity20	9.2	ITGB2, IFNA1, IFNA2, IFNG, HLA-G, TNF
26	PGC1Alpha Pathway36	9.2	IL11, IL2RG, CD4, IL16, IL1B, IL2
27	Regulation of eIF4 and p70S6K36	9.1	IL11, ITGAM, ITGB2, ITGAL, CD4, IL16
28	Molecular Mechanisms of Cancer36	8.9	CD4, ITGAM, ITGB2, IL11, IL16, IL2RG
29	Hematopoietic cell lineage20	8.8	IL6, CD3D, TNF, TFRC, CSF2, CSF3
30	MIF Mediated Glucocorticoid Regulation36	8.7	IL11, IL1B, IL16, CSF2, IL6, IL3
31	MIF Regulation of Innate Immune Cells36	8.7	IL3, CSF3, IL2, IL1B, IL16, CSF2
32	Tec Kinases Signaling36	8.7	CD3D, CD4, ITGAL, ITGAM, ITGB2, IL11
33	T cell receptor signaling pathway20	8.6	PTPRC, IFNG, IL2, CSF2, CD4, CD3D
34	all-trans-Retinoic Acid Signaling in Brain36	8.6	CSF3, IL2, IL11, IL16, IL1B, IL6
35	PEDF Induced Signaling36	8.6	IL1B, IL16, CSF3, CSF2, TNF, IL3
36	Akt Signaling36	8.6	CSF2, ITGAL, CD4, ITGAM, IL2RG, TNF
37	Rho Family GTPases36	8.6	IL11, IL3, IL2, IGF1, CSF2, ITGAM
38	Malaria20	8.5	TNF, IL6, CSF3, ITGB2, ITGAL, IFNG
39	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	8.4	IL6, CYP3A4, TNF, IFNG, IGF1, IL1B
40	Rheumatoid arthritis20	8.4	TNF, ITGAL, CSF2, IL1B, IL17A, IFNG
41	STAT3 Pathway36	8.3	CD4, IL1B, IL2, IL2RG, IL3, IL6
42	TGF-Beta Pathway36	8.3	CD4, IL1B, IL2RG, IL3, IL6, IL16
43	Measles20	8.3	CD3D, IL1B, IL2, IL2RG, IL6, IFNA1
44	Cytokine Network36	8.2	IL3, IFNA2, TNF, IFNG, IFNA1, IL6
45	Cytokine-cytokine receptor interaction20	8.0	IL2RG, IFNG, IFNA2, IFNA1, IL7R, IL6
46	Antioxidant Action of Vitamin-C36	7.9	CSF2, TNF, CSF3, IL3, IL16, CD4
47	JAK-STAT Pathway36	7.9	IL3, IL6, IFNG, IL2RG, IL2, IL1B
48	p38 Signaling36	7.8	IL2RG, IL2, IL1B, IL16, CD3D, IL11
49	ERK Signaling36	7.7	TNF, IL6, IL2, IL11, IL3, IL16
50	MAPK Family Pathway36	7.6	IL1B, IL2RG, CD4, TNF, IGF1, IL11

Compounds related to leukopenia according to GeneDecks:

(show top 50)    (show all 515)

id	Compound	Score	Top Affiliating Genes
1	vincristine32 34 9 9	13.4	ADA, CSF2, IFNA1, NCAM1
2	pge232	10.2	C5AR1, LTF, TMPO, IL17A, CD4
3	ifosfamide32 9 9	12.0	TYMS, NR1I2, CYP3A5, CYP3A4, IFNA2, IL3
4	irinotecan32 34 9 9	12.9	CYP3A5, CYP3A4, TPMT, IFNA1, GUSB, UGT1A1
5	mitoxantrone32 9 9	11.7	CSF3, CSF2, TOP1, ABCC2, ABCC1, ABCB1
6	etoposide32 42 9 9	12.6	DCLRE1C, DPYD, TOP1, ABCC2, ABCC1, ABCB1
7	rifampicin32	9.6	LTF, NR1I3, NR1I2, CYP3A5, CYP3A4, GPT
8	cytarabine32 34 9 9	12.5	ADA, CSF3, CSF2, TFRC, TOP1, TYMS
9	docetaxel32 34 9 9	12.5	NR1I2, CYP3A5, CYP3A4, IFNA1, IL3, BRCA2
10	melphalan32 9 9	11.5	CD79A, CSF2, TOP1, ABCB1, IFNG, IFNA2
11	n-formylmethionyl-leucylphenylalanine32	9.4	C5AR1, CSF3, CSF2, ELANE, LTF, IL3
12	phenobarbital32 9 9	11.4	CYP3A5, CYP3A4, ALPP, GPT, GSTM1, GUSB
13	ribavirin32 34 9 9	12.3	ADA, SLC17A5, CSF3, CSF2, LTF, IFNG
14	calcitriol32 42 9 18 9	13.1	IL2, IL11, ITGAM, ITGAL, IL3, ALB
15	vitamin b1232	9.0	ADA, TFRC, TYMS, LTF, ALPP, ALB
16	polysaccharide32	8.9	CSF2, TFRC, SELL, NCAM1, SERPINC1, BPI
17	endotoxin32	8.9	BPI, SELL, ITGAL, C5AR1, SLC17A5, CSF3
18	estrogen32	8.9	ELANE, LTF, NR1I3, NR1I2, CYP3A5, ALPP
19	zidovudine32 9 9	10.8	TFRC, TYMS, ABCC2, ABCC1, CYP3A4, TMPO
20	mycophenolate mofetil32 9 9	10.8	IFNA1, GPT, IL3, IL2, IL11, CD79A
21	doxorubicin32 34 9 9	11.6	CD19, NCAM1, ITGAL, GUSB, GSTT1, ADA
22	5fluorouracil32	8.3	GSTM1, MPO, UGT1A1, TYMS, ABCC2, ABCC1
23	chloroquine32 34 9 9	11.2	TFRC, ABCC1, ABCB1, CYP3A5, CYP3A4, TNF
24	vitamin d32	8.1	IGF1, GPT, IL6, IL3, IL11, GSTM1
25	fmlp32	8.0	ITGAL, MPO, BPI, SELL, ITGAM, ITGB2
26	h2o232	7.9	ITGAL, CD79A, FTL, FTH1, MPO, LCK
27	cisplatin32 34 9 9	10.9	SLC17A5, CSF3, CSF2, TFRC, DPYD, TOP1
28	leukotriene b432 42 18	9.9	CSF2, ELANE, LTF, TNF, IL6, IL3
29	folate32	7.9	ALPP, ALB, GSTT1, GSTM1, CD79A, FTL
30	cysteine32	7.7	TFRC, DPYD, TYMS, ELANE, LTF, HLA-G
31	thalidomide32 42 9 9	10.7	SELL, ITGB2, CSF2, CYP3A5, TNF, IFNG
32	tacrolimus32 34 9 9	10.6	ABCB1, NR1I2, CYP3A5, CYP3A4, TNF, TPMT
33	simvastatin32 34 42 9 18 9	12.4	SLC17A5, ABCB1, CRP, CYP3A5, CYP3A4, TNF
34	herbimycin a32 42	8.3	LCK, SELL, CD4, ITGB2, IL11, CSF2
35	pentoxifylline32 9 9	9.2	SELL, MPO, ITGAM, CSF2, ELANE, LTF
36	rantes32	7.1	IL16, IL11, ITGB2, ITGAM, ITGAL, CD4
37	vegf32	7.0	ALPP, NCAM1, F3, IGF1, IL1B, IL11
38	histamine32 18	7.9	ADA, ADRB2, C5AR1, CSF2, TFRC, LTF
39	hydrocortisone32 9 9	8.8	IL3, IL2, IL1B, IL6, IGF1, IFNG
40	creatinine32	6.5	TPMT, HLA-G, F3, IGF1, IL3, IL17A
41	thymidine32 18	7.3	BRCA2, UGT1A1, IFNA1, IGF1, IL6, IL3
42	methotrexate32 34 42 9 9	10.3	ADA, GPT, IL6, IL1B, IL17A, GSTM1
43	alanine32	6.2	C5AR1, SLC17A5, TFRC, ABCB7, LTF, CRP
44	lactate32	6.0	HLA-G, ALPP, ALB, GPT, IL6, IL3
45	genistein32 9 18 9	8.8	CSF2, TFRC, ABCC2, ABCC1, ABCB1, PTPRC
46	indomethacin32 9 9	7.8	IL2, IL1B, IL17A, IL11, ITGB2, ITGAM
47	prednisolone32 9 9	7.6	C5AR1, SLC17A5, CSF3, ABCB1, CRP, ITGAL
48	retinoic acid32 42 18	7.2	IL3, NCAM1, IL1B, IL11, ITGB2, ITGAM
49	cycloheximide32	4.9	C5AR1, CSF3, IL6, IL3, IL2, IL1B
50	dexamethasone32 42 34 9 9	8.2	IL1B, NCAM1, SELL, SERPINC1, IL17A, IL16

Cellular components related to leukopenia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	Fanconi anaemia nuclear complex	GO:043240	10.2	FANCL, FANCM, FANCG, FANCC, FANCF, FANCE
2	nucleoplasm	GO:005654	9.2	FANCE, FANCL, FANCD2, PALB2, LIG4, RAD51C
3	secretory granule	GO:030141	8.9	ELANE, IL1B, MPO, BRCA2, LTF
4	integral to plasma membrane	GO:005887	8.5	ABCC2, TFRC, SLC17A5, SLCO1B3, C5AR1, ADRB2
5	external side of plasma membrane	GO:009897	7.9	CD19, CD4, CD79A, SELL, NCAM1, CD5
6	plasma membrane	GO:005886	5.9	IL7R, FANCI, GOT2, F3, IL2RG, IL16
7	extracellular region	GO:005576	5.5	IL3, ELANE, IL2, IL1B, IL11, CDA
8	extracellular space	GO:005615	5.4	IFNG, ALB, ALPL, TNF, CRP, CSF2

Biological processes related to leukopenia according to GeneDecks:

(show all 25)

id	Name	GO ID	Score	Top Affiliating Genes
1	V(D)J recombination	GO:033151	10.5	LIG4, RAG2, RAG1
2	B cell differentiation	GO:030183	10.1	RAG2, NHEJ1, DCLRE1C, PTPRC, IL11, CD79A
3	positive regulation of interleukin-23 production	GO:032747	10.1	CSF2, IFNG, IL17A
4	regulation of immune response	GO:050776	10.0	CD3D, SELL, CD19, ITGB2, HLA-G, ITGAL
5	positive regulation of tyrosine phosphorylation of Stat5 protein	GO:042523	9.9	IL3, IGF1, IL2, CSF2
6	leukocyte migration	GO:050900	9.8	SELL, LCK, ITGAL, ITGAM, ITGB2, ELANE
7	DNA repair	GO:006281	9.7	BRCA2, SLX4, TYMS, FANCB, FANCM, FANCG
8	positive regulation of MAPK cascade	GO:043410	9.7	ADRB2, IL11, PTPRC, IGF1, IL6
9	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.7	IL6, IL11, CD4, IL3, IGF1
10	T cell differentiation	GO:030217	9.6	LCK, PTPRC, CD4, IL2, NHEJ1, CD3D
11	response to gamma radiation	GO:010332	9.6	IL1B, FANCD2, LIG4, PTPRC, BRCA2
12	negative regulation of inflammatory response	GO:050728	9.6	ADRB2, IL2, ADA, SERPINC1, ELANE
13	positive regulation of isotype switching to IgG isotypes	GO:048304	9.5	IL2, IFNG, PTPRC
14	cell surface receptor signaling pathway	GO:007166	9.4	IFNA2, IFNG, CD3D, CD4, CD19, CDA
15	immune response	GO:006955	9.4	IL17A, CSF2, BPI, RAG1, FTH1, CD4
16	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	9.2	TNF, IL1B, IFNG
17	negative regulation of lipid storage	GO:010888	9.1	IL6, TNF, CRP
18	positive regulation of cell proliferation	GO:008284	9.0	CSF3, IL6, ADRB2, CSF2, IGF1, IL3
19	blood coagulation	GO:007596	9.0	SELL, RAD51C, LCK, ITGAL, ITGAM, ITGB2
20	small molecule metabolic process	GO:044281	9.0	SLCO1B3, DPYD, ADA, TYMS, ABCB1, CYP3A5
21	positive regulation of T cell proliferation	GO:042102	8.9	PTPRC, IFNG, IL1B, IL6, ITGAL
22	positive regulation of chemokine biosynthetic process	GO:045080	8.9	IFNG, IL1B, TNF
23	neutrophil chemotaxis	GO:030593	8.9	IFNG, C5AR1, ITGB2, IL1B
24	transmembrane transport	GO:055085	8.8	ABCB1, ABCC1, ABCC2, TFRC, SLC17A5, SLCO1B3
25	inflammatory response	GO:006954	7.7	ITGAL, ITGB2, CRP, IFNA2, IL1B, IL17A

Molecular functions related to leukopenia according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	ferric iron binding	GO:008199	10.1	LTF, FTL, FTH1
2	alkaline phosphatase activity	GO:004035	10.0	ALPPL2, ALPP, ALPL
3	glycoprotein binding	GO:001948	9.7	CD4, CD5, ITGB2, ITGAM, LCK
4	protease binding	GO:002020	9.4	SELL, SERPINC1, BRCA2, F3, TNF, ELANE
5	heparin binding	GO:008201	9.0	LTF, PTPRC, MPO, SERPINC1, SELL, ELANE
6	growth factor activity	GO:008083	8.6	IL2, IL3, IL6, IGF1, CSF2, CSF3
7	cytokine activity	GO:005125	7.8	IL3, IL11, IL16, IL17A, IL1B, IL2
8	protein binding	GO:005515	4.9	TNF, ALB, TMPO, F3, IFNA2, IGF1