MCID: LKP004
MIFTS: 32

Leukopenia malady

Summaries for Leukopenia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Leukopenia (also known as leukocytopenia, or leucopenia, from Greek λευκό - white and πενία... more...

MalaCards: Leukopenia is related to thrombocytopenia and neutropenia. An important gene associated with Leukopenia is ITPA (inosine triphosphatase (nucleoside triphosphate pyrophosphatase)), and among its related pathways are Ifosfamide Pathway, Pharmacokinetics and Gefitinib Pathway, Pharmacokinetics. The compounds 6 mercaptopurine and creatinine have been mentioned in the context of this disorder. Related mouse phenotypes are integument and hematopoietic system.

Aliases & Classifications for Leukopenia

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10DISEASES, 44Novoseek, 60UMLS
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Aliases & Descriptions:

leukopenia 10 44 60


Related Diseases for Leukopenia

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17GeneCards, 18GeneDecks
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Diseases related to Leukopenia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 235)
idRelated DiseaseScoreTop Affiliating Genes
1thrombocytopenia31.0IFNA2, IDUA, CSF2, CSF3, GUSB, TPMT
2neutropenia30.6TPMT, GPT, IL11, CYP3A4, TYMS, ITGAM
3leukemia30.5TPMT, TMPO, IL11, CYP3A4, TYMS, FLT3LG
4acute leukemia30.3IDUA, CSF2, CSF3, TFRC, HLA-G, ITGAM
5lung cancer30.3CSF2, CSF3, GUSB, HLA-G, UGT1A1, TYMS
6hepatitis30.3SLC17A5, GPT
7arthritis30.2ITGAM, GUSB, CSF2
8gingivitis30.1GUSB
9rheumatoid arthritis30.1HLA-G, GUSB, TFRC, CSF2, BPI, ITGAM
10pancreatitis30.1ITPA, IL11, SLC17A5, TPMT
11dermatitis30.1CSF2
12pneumonia30.1BPI, CSF2, CSF3, ITGAM, FLT3LG, TYMS
13inflammatory bowel disease30.1BPI, GUSB, HLA-G, ITPA, IL11, TPMT
14vasculitis30.1TPMT, ITGAM, IFNA2, BPI
15breast cancer30.1CSF2, CSF3, HLA-G, UGT1A1, FLT3LG, TYMS
16felty's syndrome30.1CSF2, CSF3
17sarcoma29.9GUSB, CYP3A4
18diarrhea29.9UGT1A1, TYMS, CYP3A4
19myocardial infarction29.9ITGAM, IL11, ABCB7
20malaria29.9TFRC, TYMS
21myeloid leukemia29.9CSF2, CSF3, TFRC, ITGAM, IL11
22aplastic anemia29.9CSF2, CSF3, TFRC, FLT3LG, CYP3A4, IL11
23ischemia29.9SLC17A5, CYP3A4
24tuberculosis29.9BPI, GUSB, ITGAM, TYMS, CYP3A4, IL11
25acute lymphocytic leukemia29.9CSF2, CSF3, GUSB, UGT1A1, ITGAM, TYMS
26liver cirrhosis29.9BPI, IFNA2, CYP3A4, IL11, GPT, ABCB7
27hepatitis c29.9IFNA2, GPT, ABCB7, SLC17A5
28influenza29.7TMPO, IL11, CYP3A4
29ulcerative colitis29.7BPI, GUSB, HLA-G, ITPA, IL11, TPMT
30deficiency anemia29.7CSF2, IFNA2, CSF3, TFRC, TPMT, TMPO
31hepatocellular carcinoma29.7IFNA2, UGT1A1, CYP3A4, GPT, ABCB7, SLC17A5
32colon cancer29.7GUSB, UGT1A1, TYMS, CYP3A4
33prostate cancer29.7IL11, CYP3A4, TFRC
34melanoma29.7IFNA2, CSF2, TFRC, GUSB, HLA-G, FLT3LG
35acute myocardial infarction29.7TFRC, ITGAM, ABCB7
36ovarian cancer29.7CSF2, CSF3, GUSB, HLA-G, TYMS, CYP3A4
37hepatitis b29.7IFNA2, TFRC, GPT, ABCB7, SLC17A5, TMPO
38pancreatic cancer29.7TYMS, GUSB
39cervical cancer29.7HLA-G
40atherosclerosis29.7ITGAM
41hemolytic anemia29.7UGT1A1, TFRC, IFNA2
42proteinuria29.7ABCB7, HLA-G
43alcohol abuse29.7GPT, ABCB7, SLC17A5
44neonatal jaundice29.7UGT1A1, GUSB
45reticular dysgenesis10.2
46systemic lupus erythematosus10.2
47lupus erythematosus10.2
48burns10.1
49crohn's disease10.1
50anorexia nervosa10.1

Graphical network of the top 20 diseases related to Leukopenia:



Diseases related to leukopenia

Clinical Features for Leukopenia

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Drugs & Therapeutics for Leukopenia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Leukopenia

Drug clinical trials:

Search ClinicalTrials for Leukopenia

Search NIH Clinical Center for Leukopenia

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Genetic Tests for Leukopenia

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Anatomical Context for Leukopenia

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Animal Models for Leukopenia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Leukopenia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001077110.5TMPO, GUSB, IDUA
2MP:000539710.3FLT3LG, TPMT, ITPA, ITGAM, HLA-G, GUSB
3MP:000538410.1TMPO, IDUA, SLC17A5, ABCB7, FLT3LG, ITPA

Publications for Leukopenia

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Genetic Variations for Leukopenia

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Expression for genes affiliated with Leukopenia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Leukopenia

Search GEO for disease gene expression data for Leukopenia.

Pathways for genes affiliated with Leukopenia

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Sources:
49PharmGKB, 37NCBI BioSystems Database, 29KEGG, 53Reactome
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Compounds for genes affiliated with Leukopenia

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Leukopenia according to GeneCards/GeneDecks:

(show top 50)    (show all 225)
idCompoundScoreTop Affiliating Genes
16 mercaptopurine4410.9GPT, ITPA, UGT1A1, CSF3, TPMT
2creatinine4410.8TYMS, BPI, GUSB, HLA-G, ITGAM, GPT
3mycophenolate mofetil44 49 1112.8GPT, TPMT, CYP3A4, CSF3, UGT1A1, TFRC
4leucovorin44 49 1112.8TMPO, UGT1A1, TYMS, IFNA2, CSF2, CSF3
5filgrastim44 1111.8ITGAM, IL11, CSF2, IFNA2, CSF3
6ribavirin44 49 1112.8IFNA2, SLC17A5, GPT, ITPA, CSF3, CSF2
7lactate4410.8HLA-G, GUSB, TFRC, CSF2, TYMS, BPI
8prednisolone44 28 1112.8SLC17A5, GPT, CYP3A4, ITGAM, CSF3, TPMT
9ifosfamide44 1111.8IL11, CSF2, IFNA2, CYP3A4, TYMS, CSF3
10cytarabine44 49 1112.8TPMT, IL11, CYP3A4, TYMS, TFRC, CSF3
11neopterin4410.8IFNA2, CSF2, TFRC, HLA-G, GPT, SLC17A5
125fluorouracil4410.8TPMT, IFNA2, CSF2, CSF3, UGT1A1, TYMS
13irinotecan44 49 1112.8TYMS, TPMT, CYP3A4, UGT1A1, GUSB, CSF3
14silymarin4410.8GPT, ABCB7, SLC17A5, GUSB, UGT1A1
15cyclosporin a44 28 5912.8GPT, CSF2, TPMT, SLC17A5, IL11, CYP3A4
16purine44 2411.8TYMS, SLC17A5, TPMT, IFNA2, ITGAM, ITPA
17zidovudine44 1111.8TFRC, TMPO, IFNA2, GUSB, TYMS, CYP3A4
18ethanol44 49 11 2413.8GUSB, ITGAM, CYP3A4, IL11, GPT, BPI
19doxorubicin44 49 1112.8GUSB, CSF2, CSF3, TFRC, TYMS, CYP3A4
20dexamethasone44 49 28 1113.8ITGAM, CYP3A4, IDUA, UGT1A1
21cyclophosphamide44 49 1112.8TPMT, CSF2, IFNA2, IL11, CYP3A4, FLT3LG
22methotrexate44 49 1112.8GPT, HLA-G, TYMS, SLC17A5, ITPA, TPMT
23hydroxyurea44 49 1112.8TFRC, CSF3, TYMS, CSF2, UGT1A1, IFNA2
24pixy3214410.8CSF2, IL11, FLT3LG, CSF3
25aspartate4410.8GPT, ABCB7, IFNA2, TFRC, GUSB, UGT1A1
26mitoxantrone44 49 1112.8CSF2, IDUA, IFNA2, CSF3, CYP3A4
27thymidine44 2411.8FLT3LG, ITGAM, UGT1A1, TFRC, TYMS, CSF3
28heparin44 28 11 2413.8CSF2, ITGAM, GUSB, ABCB7, BPI, IL11
29methylcellulose4410.7FLT3LG, TFRC, CSF3, IL11, CSF2
30idarubicin44 49 1112.7IL11, CSF3, CSF2, IDUA
31vegf4410.7TYMS, FLT3LG, ITGAM, HLA-G, TFRC, CSF3
32etoposide44 49 59 1113.7TYMS, IL11, UGT1A1, CSF3, IFNA2, CYP3A4
33cisplatin44 49 59 1113.7SLC17A5, TFRC, TPMT, UGT1A1, TYMS, CSF3
34endotoxin4410.7BPI, SLC17A5, IL11, ITGAM, CSF3
35histamine44 28 2412.7TPMT, TFRC, IFNA2, GUSB, ITGAM, CSF2
36vitamin b124410.7TYMS, TFRC, GPT, SLC17A5, GUSB
37nevirapine44 49 1112.7GPT, ABCB7, SLC17A5
38daunorubicin44 49 1112.7GUSB, CSF3, IDUA, CSF2, CYP3A4
39thiopurine4410.7ITPA, TYMS, TPMT, UGT1A1
40alanine4410.7SLC17A5, TPMT, IFNA2, IL11, BPI, GPT
41tacrolimus44 49 1112.6CYP3A4, TFRC, TPMT, SLC17A5, IL11, GPT
42buprenorphine44 28 1112.6UGT1A1, SLC17A5, GUSB, CYP3A4
43dmso4410.6CSF3, CSF2, SLC17A5, TYMS, ITGAM, TFRC
44acetaminophen44 2 49 11 2414.6CYP3A4, GPT, UGT1A1, CSF2, SLC17A5
45pge14410.5IL11, TFRC, GUSB, GPT, SLC17A5
46carboplatin44 49 1112.5IL11, CSF3, CSF2, IFNA2, TYMS
47sn 3844 5911.4TYMS, CYP3A4, UGT1A1, GUSB
48tyrosine4410.4SLC17A5, TPMT, TMPO, IL11, FLT3LG, ITGAM
49phenobarbital44 28 1112.3GUSB, UGT1A1, CYP3A4, GPT, SLC17A5
50retinoic acid44 2411.1IL11, CYP3A4, ITGAM, BPI, IFNA2, CSF2

GO Terms for genes affiliated with Leukopenia

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16Gene Ontology
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Biological processes related to Leukopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heterocycle metabolic processGO:04648310.5CYP3A4, UGT1A1
2small molecule metabolic processGO:04428110.1TPMT, IDUA, GUSB, UGT1A1, ITPA, TYMS

Molecular functions related to Leukopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.4IL11, FLT3LG, CSF3, CSF2, IFNA2

Products for genes affiliated with Leukopenia

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  • Antibodies
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Sources for Leukopenia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet