MCID: LKP004
MIFTS: 45

Leukopenia malady

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Summaries for Leukopenia

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Wikipedia:65 Leukopenia (also known as leukocytopenia, or leucopenia, from Greek ????? - white and ????? -deficiency)... more...

MalaCards based summary: Leukopenia is related to bacteremia and inflammatory bowel disease. An important gene associated with Leukopenia is ITPA (inosine triphosphatase (nucleoside triphosphate pyrophosphatase)), and among its related pathways are One carbon pool by folate and Heparan sulfate/heparin (HS-GAG) metabolism. The compounds purine analogues and acetaminophen glucuronide have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and bone, and related mouse phenotypes are hematopoietic system and growth/size/body.

Aliases & Classifications for Leukopenia

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Sources:
10DISEASES, 44Novoseek, 62UMLS
See all sources

Leukopenia, Aliases & Descriptions:

Name: Leukopenia 10 44 62


Related Diseases for Leukopenia

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Diseases related to Leukopenia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 169)
idRelated DiseaseScoreTop Affiliating Genes
1bacteremia30.5GUSB, BPI
2inflammatory bowel disease30.5TPMT, ITPA
3thrombocytopenia30.5SLC17A5, TPMT, GUSB, IDUA, ABCB7
4leukemia30.3IDUA, TPMT, GUSB, HLA-G
5hepatitis30.3SLC17A5, GUSB
6acute leukemia30.3HLA-G, TPMT, IDUA
7vasculitis30.2TPMT, BPI
8pancreatitis30.2ITPA, SLC17A5, TPMT
9rheumatoid arthritis30.1GUSB, TPMT, BPI, HLA-G
10gaucher's disease30.1IDUA, GUSB
11acute lymphoblastic leukemia30.1UGT1A1, TPMT, GUSB
12liver cirrhosis29.9ABCB7, SLC17A5, BPI
13alcohol abuse29.9ABCB7, SLC17A5
14hepatitis b29.9ABCB7, SLC17A5
15hepatitis c29.7ITPA, SLC17A5, ABCB7
16colorectal cancer29.4GUSB, TPMT, HLA-G, UGT1A1
17ulcerative colitis29.4HLA-G, ITPA, BPI, TPMT, GUSB
18neutropenia10.5
19pre-eclampsia10.3HLA-G
20reticular dysgenesis10.3
21wegener's granulomatosis10.3TPMT, BPI
22fascioliasis10.3SLC17A5
23cholangitis10.3SLC17A5
24arthritis10.3
25lung cancer10.3
26granulocytopenia10.3
27sly syndrome10.2IDUA, GUSB
28gilbert syndrome10.2UGT1A1, TPMT
29mucopolysaccharidosis10.2IDUA, GUSB
30systemic lupus erythematosus10.2
31lupus erythematosus10.2
32lysosomal storage disease10.2IDUA, GUSB
33burns10.2
34crohn's disease10.2
35hypertension10.2
36anorexia nervosa10.2
37gingivitis10.2
38pneumonia10.2
39sepsis10.2
40neonatal jaundice10.1GUSB, UGT1A1
41cholelithiasis10.1GUSB, UGT1A1
42deficiency anemia10.1TPMT, ABCB7, ITPA
43pulmonary hypertension10.1
44propionic acidemia10.1
45tick-borne encephalitis10.1
46felty's syndrome10.1
47breast cancer10.1
48dermatitis10.1
49encephalitis10.1
50lymphoblastic leukemia10.1

Graphical network of the top 20 diseases related to Leukopenia:



Diseases related to leukopenia

Symptoms for Leukopenia

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Drugs & Therapeutics for Leukopenia

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Drug clinical trials:

Search ClinicalTrials for Leukopenia

Search NIH Clinical Center for Leukopenia

Genetic Tests for Leukopenia

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Anatomical Context for Leukopenia

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MalaCards organs/tissues related to Leukopenia:

32
Lung, Liver, Bone, Kidney, T cells, Bone marrow, Breast, Neutrophil, Pancreas, Testes, Myeloid, Heart, Monocytes, Whole blood, Spleen, Colon, Prostate

Animal Models for Leukopenia or affiliated genes

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MGI Mouse Phenotypes related to Leukopenia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.4ITPA, TPMT, GUSB, IDUA, HLA-G
2MP:00053787.6SLC17A5, ITPA, TPMT, GUSB, IDUA, ABCB7
3MP:00107687.3ABCB7, IDUA, GUSB, TPMT, ITPA, SLC17A5
4MP:00053767.3ABCB7, HLA-G, IDUA, GUSB, TPMT, SLC17A5

Publications for Leukopenia

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Articles related to Leukopenia:

(show top 50)    (show all 518)
idTitleAuthorsYear
1
The effect of rhG-CSF on spleen transcriptome in mouse leukopenia model induced by cyclophosphamide. (24611752)
2014
2
Prognostic significance of leukopenia in childhood acute lymphoblastic leukemia. (24944687)
2014
3
Immunoproteomic to analysis the pathogenicity factors in leukopenia caused by Klebsiella pneumonia bacteremia. (25330314)
2014
4
Effect of recombinant Ganoderma lucidum immunoregulatory protein on cyclophosphamide-induced leukopenia in mice. (23656432)
2013
5
G-CSF plus plerixafor (Mozobil) to mobilize hematopoietic stem cells in patients with thrombocytopenia or leukopenia prior to auto-SCT. (22773123)
2013
6
Leukopenia as a risk factor for osteonecrosis of the jaw in metastatic prostate cancer treated using zoledronic acid and docetaxel. (22578070)
2012
7
Preterm neonates show marked leukopenia and lymphopenia that are associated with increased regulatory T-cell values and diminished IL-7. (22398700)
2012
8
Clozapine-induced late leukopenia. (20872253)
2012
9
Lamotrigine-associated thrombocytopenia and leukopenia. (20656445)
2012
10
Genetic determinants of mycophenolate-related anemia and leukopenia after transplantation. (21107304)
2011
11
Influence of granulocyte colony-stimulating factor on cardiac function in patients with acute myocardial infarction and leukopenia after revascularization. (20819563)
2010
12
Valganciclovir-induced leukopenia in liver transplant recipients: influence of concomitant use of mycophenolate mofetil. (19376423)
2009
13
Leukopenia due to parvovirus B19 in a Crohn's disease patient using azathioprine. (19390192)
2009
14
Cephalosporin-induced leukopenia following rechallenge with cefoxitin. (18648015)
2008
15
Cordyceps sinensis health supplement enhances recovery from taxol-induced leukopenia. (18367634)
2008
16
Incidence and temporal pattern of anorexia, diarrhea, weight loss, and leukopenia in patients with cervical cancer treated with concurrent radiation therapy and weekly cisplatin: comparison with radiation therapy alone. (16527337)
2006
17
Leukopenia due to anti-tuberculous chemotherapy including rifampicin and isoniazid]. (15211874)
2004
18
KF24345, an adenosine uptake inhibitor, suppresses lipopolysaccharide-induced tumor necrosis factor-alpha production and leukopenia via endogenous adenosine in mice. (11752117)
2002
19
Pathogenesis of pneumococcal pneumonia in cyclophosphamide-induced leukopenia in mice. (12117931)
2002
20
Venlafaxine in a patient with idiopathic leukopenia and mirtazapine-induced severe neutropenia. (12363126)
2002
21
Leukopenia and thrombocytopenia in pigs after infection with bovine viral diarrhoea virus-2 (BVDV-2). (12073495)
2002
22
Transient leukopenia and anaphylatoxin production during granulocyte apheresis as treatment for ulcerative colitis. (12378544)
2002
23
Initiation of clozapine therapy in a patient with preexisting leukopenia: a discussion of the rationale of current treatment options. (11958365)
2001
24
Monocyte deactivation and its reversal in a patient with chemotherapy-induced leukopenia and severe systemic infection. (10611583)
2000
25
Steroids may prevent leukopenia, interfering with response to IV azathioprine in treatment of Crohn's disease. (10866522)
2000
26
Retrovirus-mediated gene transfer of the human multidrug resistance-associated protein into hematopoietic cells protects mice from chemotherapy-induced leukopenia. (10210147)
1999
27
Does chemotherapy-induced leukopenia predict a response in small-cell lung cancer? (9654193)
1998
28
Leukopenia prognosis during radiation therapy in patients with Hodgkin's disease. (9505215)
1997
29
Leukopenia prognosis by radiation therapy of patients with Hodgkin's disease. (9261745)
1997
30
Conditioning of cyclophosphamide-induced leukopenia in humans. (9081556)
1996
31
Granulocyte colony stimulating factor in the treatment of alcohol abuse, leukopenia, and pneumococcal sepsis. (7530862)
1995
32
Biologic effects and possible therapeutic use of the granulocyte-macrophage colony-stimulating factor. Modern treatment of leukopenia]. (7725160)
1993
33
Protective effect of ren-shen-yang-rong-tang (Ninjin-youei-to) in mice with drug-induced leukopenia against Pseudomonas aeruginosa infection. (1280629)
1992
34
Expression of a human multidrug resistance cDNA (MDR1) in the bone marrow of transgenic mice: resistance to daunomycin-induced leukopenia. (2573831)
1989
35
Chronic leukopenia associated with feline immunodeficiency virus infection in a cat. (2537275)
1989
36
A study on the mechanism of anemia and leukopenia in liver cirrhosis. (3418979)
1988
37
Changes in electrical charge of leukocyte surface membranes during hemodialysis. Possible role in transient leukopenia. (3196572)
1988
38
Benign familial leukopenia and neutropenia in different ethnic groups. (3181399)
1988
39
Long-term prophylaxis of infection by selective decontamination in leukopenia and in mechanical ventilation. (3296099)
1987
40
Serum lithium concentrations and peripheral leukocytes in a case of leukopenia. (3741920)
1986
41
Anaphylatoxin C5a generation and dialysis-induced leukopenia with different hemodialyzer membranes. (3730166)
1986
42
Leukopenia in Still's disease. (6481933)
1984
43
More on penicillin-induced leukopenia. (6835289)
1983
44
Isolated lateral rectus muscle palsy associated with leukopenia in two adults. (7137280)
1982
45
Lithium, biphasic granulocytosis and antiblastic leukopenia prevention. (6780428)
1980
46
Quinidine leukopenia and thrombocytopenia with a drug-dependent leukoagglutinin. (836544)
1977
47
Leukopenia in alcoholics. (4701945)
1973
48
Congenital lipomatosis of the pancreas. Malabsorption, dwarfism, leukopenia with relative granulocytopenia and thrombocytopenia. (5665293)
1968
49
Replacement transfusion therapy of thrombocytopenia and leukopenia. (5856194)
1964
50
Familial leukopenia-neutropenia in Yemenite Jews. Observations on eleven families. (13723164)
1961

Variations for Leukopenia

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Expression for genes affiliated with Leukopenia

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Expression patterns in normal tissues for genes affiliated with Leukopenia

Search GEO for disease gene expression data for Leukopenia.

Pathways for genes affiliated with Leukopenia

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Pathways related to Leukopenia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
One Carbon Metabolism37
dTMP de novo biosynthesis (mitochondrial)37
tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate37
Trans-sulfuration and one carbon metabolism37
methionine salvage37
Methionine metabolism60
9.8TPMT, ITPA
2
Show member pathways
9.5IDUA, GUSB
3
Show member pathways
9.5IDUA, GUSB
4
Show member pathways
tetrapyrrole biosynthesis37
heme degradation37
Heme Biosynthesis37
heme biosynthesis37
heme biosynthesis from uroporphyrinogen-III I37
9.3UGT1A1, GUSB
58.7IDUA, GUSB, SLC17A5
6
Show member pathways
8.7ITPA, TPMT, GUSB, UGT1A1
7
Show member pathways
7.8ABCB7, ITPA, TPMT, GUSB, IDUA, UGT1A1

Compounds for genes affiliated with Leukopenia

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Sources:
50PharmGKB, 44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR
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Compounds related to Leukopenia according to GeneCards/GeneDecks:

(show top 50)    (show all 141)
idCompoundScoreTop Affiliating Genes
1purine analogues5010.2TPMT, ITPA
2acetaminophen glucuronide44 2410.7GUSB, UGT1A1
3sn38 glucuronide449.7GUSB, UGT1A1
4morphine-3-glucuronide449.7UGT1A1, GUSB
54-methylumbelliferone449.7GUSB, UGT1A1
6udp glucuronic acid449.7UGT1A1, GUSB
7ethyl glucuronide44 2410.7UGT1A1, GUSB
8lamotrigine44 50 1111.7UGT1A1, GUSB
9glucuronide449.7GUSB, UGT1A1
10Dehydroepiandrosterone 3-glucuronide249.7GUSB, UGT1A1
11Cotinineglucuronide249.6UGT1A1, GUSB
12Inodxyl glucuronide249.6GUSB, UGT1A1
13thiopurine449.6UGT1A1, ITPA, TPMT
146 mercaptopurine449.6ITPA, UGT1A1, TPMT
15Isovalerylglucuronide249.6GUSB, UGT1A1
16Ketoprofen glucuronide249.6GUSB, UGT1A1
17Lithocholate 3-O-glucuronide249.6GUSB, UGT1A1
18Tyramine glucuronide249.6GUSB, UGT1A1
19Valproic acid glucuronide249.6GUSB, UGT1A1
20opium449.6SLC17A5, GUSB
21Vitamin D2 3-glucuronide249.6GUSB, UGT1A1
22beta-hydroxybutyrate449.5SLC17A5, ABCB7
23Cortolone-3-glucuronide249.5UGT1A1, GUSB
24bilirubin diglucuronide44 2410.5UGT1A1, GUSB
25lactulose449.5GUSB, SLC17A5
26glycocholate449.5GUSB, SLC17A5
27(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)249.5GUSB, UGT1A1
281-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid249.4GUSB, UGT1A1
292-Phenylethanol glucuronide249.4GUSB, UGT1A1
30irinotecan44 50 1111.4UGT1A1, GUSB, TPMT
31purine44 2410.4ITPA, TPMT, SLC17A5
3225-Hydroxyvitamin D2 25-(beta-glucuronide)249.3GUSB, UGT1A1
33Cholic acid glucuronide249.3GUSB, UGT1A1
3425-Hydroxyvitamin D2-25-glucuronide249.2GUSB, UGT1A1
353,17-Androstanediol glucuronide249.0GUSB, UGT1A1
36buprenorphine44 28 1110.9SLC17A5, UGT1A1, GUSB
37thyroxine44 249.9UGT1A1, ABCB7, SLC17A5
38phenobarbital44 28 50 1111.9UGT1A1, GUSB, SLC17A5
39morphine44 50 28 1111.9SLC17A5, UGT1A1, GUSB
40methotrexate50 44 1110.9TPMT, ITPA, SLC17A5, HLA-G
41magnesium44 24 1110.9ABCB7, SLC17A5, BPI, ITPA
42urea44 24 1110.8SLC17A5, BPI, HLA-G, ABCB7
43ethanol44 50 24 1111.7SLC17A5, BPI, GUSB, ABCB7
44silymarin448.5SLC17A5, UGT1A1, GUSB, ABCB7
45aspartate448.4UGT1A1, GUSB, ABCB7, SLC17A5
46heparin44 28 24 1111.3ABCB7, IDUA, GUSB, BPI, SLC17A5
47alanine448.3UGT1A1, ABCB7, TPMT, BPI, SLC17A5
48lactate448.2SLC17A5, BPI, GUSB, ABCB7, HLA-G
49cholesterol44 28 24 1111.1ABCB7, UGT1A1, HLA-G, BPI, SLC17A5
50creatinine447.9HLA-G, GUSB, SLC17A5, BPI, TPMT, ABCB7

GO Terms for genes affiliated with Leukopenia

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Cellular components related to Leukopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lysosomal lumenGO:0432029.5GUSB, IDUA

Biological processes related to Leukopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glycosaminoglycan catabolic processGO:0060279.5GUSB, IDUA
2small molecule metabolic processGO:0442817.5ITPA, TPMT, GUSB, IDUA, UGT1A1, ABCB7

Products for genes affiliated with Leukopenia

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Sources for Leukopenia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet