Aliases & Classifications for Leukoplakia

Aliases & Descriptions for Leukoplakia:

Name: Leukoplakia 50 52 69

Classifications:



Summaries for Leukoplakia

NIH Rare Diseases : 50 leukoplakia is a condition in which thickened, white patches form on the tongue, gums, inside of the cheek, or sometimes on the outer female genitals. although the sores can vary in appearance, they are usually white or gray; thick; and slightly raised with a hard surface. the condition is thought to be caused by irritation, but the cause is not always known. tobacco is considered to be the main cause of its development in the mouth. most patches are benign, but a small percentage show early signs of cancer. removing the source of irritation may cause the condition to go away, but surgery to remove the sore(s) may be necessary in some cases. last updated: 5/21/2012

MalaCards based summary : Leukoplakia is related to oral hairy leukoplakia and oral leukoplakia. An important gene associated with Leukoplakia is KRT4 (Keratin 4), and among its related pathways/superpathways are Keratinization and Acetaminophen Pathway (therapeutic doses), Pharmacokinetics. The drugs Aminolevulinic acid and Dermatologic Agents have been mentioned in the context of this disorder. Affiliated tissues include tongue, t cells and testes, and related phenotype is Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435).

Wikipedia : 71 Leukoplakia generally refers to a firmly attached white patch on a mucous membrane which is associated... more...

Related Diseases for Leukoplakia

Diseases related to Leukoplakia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)
id Related Disease Score Top Affiliating Genes
1 oral hairy leukoplakia 12.4
2 oral leukoplakia 12.3
3 uterine cervix leukoplakia 12.0
4 oral mucosa leukoplakia 12.0
5 leukoplakia of penis 12.0
6 leukoplakia of vagina 12.0
7 esophageal leukoplakia 12.0
8 dyskeratosis congenita 11.3
9 dyskeratosis congenita, autosomal recessive 5 10.9
10 dyskeratosis congenita, autosomal recessive 1 10.8
11 dyskeratosis congenita, autosomal recessive 6 10.8
12 dyskeratosis congenita, autosomal dominant 6 10.8
13 dyskeratosis congenita, autosomal recessive 3 10.8
14 dyskeratosis congenita, autosomal dominant 2 10.8
15 dyskeratosis congenita, x-linked 10.8
16 dyskeratosis congenita, autosomal dominant 3 10.8
17 balanitis xerotica obliterans 10.8
18 poikiloderma with neutropenia 10.7
19 pachyonychia congenita 1 10.7
20 pachyonychia congenita 2 10.7
21 dyskeratosis congenita, autosomal dominant 1 10.7
22 dyskeratosis congenita, autosomal recessive 2 10.7
23 pachyonychia congenita 3 10.7
24 pachyonychia congenita 4 10.7
25 mouth disease 10.7
26 revesz syndrome 10.7
27 squamous cell carcinoma 10.5
28 oral squamous cell carcinoma 10.4
29 lichen planus 10.3
30 oral cancer 10.3
31 extramedullary plasmacytoma 10.2 MKI67 PCNA
32 brachydactyly small stature face anomalies 10.2 MKI67 PCNA
33 differentiated thyroid carcinoma 10.2 GSTM1 GSTT1
34 common bile duct neoplasm 10.2 MKI67 PCNA
35 emery-dreifuss muscular dystrophy, x-linked 10.2 GSTM1 GSTT1
36 oral submucous fibrosis 10.2
37 oral lichen planus 10.2
38 villous adenoma 10.2 GSTM1 GSTT1
39 isolated klippel-feil syndrome 10.2 CYP1A1 GSTM1
40 gastrointestinal tularemia 10.2 GSTM1 GSTT1
41 tenosynovitis 10.2 GSTM1 GSTT1
42 byssinosis 10.2 GSTM1 GSTT1
43 candidiasis 10.1
44 oro-mandibular-limb hypogenesis syndrome 10.1 GSTM1 MKI67 PCNA
45 mycobacterium kansasii 10.1 GSTM1 GSTT1
46 oral candidiasis 10.1
47 hepatic flexure cancer 10.1 GSTM1 GSTT1 MKI67
48 onychodystrophy-anonychia 10.1 KRT8 PCNA
49 ladd syndrome 10.1 GSTM1 GSTT1 MKI67
50 esophageal neuroendocrine tumor 10.1 CYP1A1 GSTM1 GSTT1

Graphical network of the top 20 diseases related to Leukoplakia:



Diseases related to Leukoplakia

Symptoms & Phenotypes for Leukoplakia

GenomeRNAi Phenotypes related to Leukoplakia according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 8.8 DKC1 MKI67 PCNA

Drugs & Therapeutics for Leukoplakia

Drugs for Leukoplakia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 58)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aminolevulinic acid Approved Phase 3,Phase 1,Phase 2 106-60-5 137
2 Dermatologic Agents Phase 3,Phase 1,Phase 2
3 Photosensitizing Agents Phase 3,Phase 1,Phase 2
4
Celecoxib Approved, Investigational Phase 2 169590-42-5 2662
5
Rosiglitazone Approved, Investigational Phase 2 122320-73-4 77999
6
Pioglitazone Approved, Investigational Phase 2 111025-46-8 4829
7
Ketorolac Approved Phase 2 74103-06-3, 66635-83-4 3826
8
Trioxsalen Approved Phase 2 3902-71-4 5585
9
Metformin Approved Phase 2 657-24-9 14219 4091
10
Maleic acid Experimental Phase 2 110-16-7 444266
11
Fenretinide Investigational Phase 2 65646-68-6
12 Analgesics Phase 2,Phase 1
13 Analgesics, Non-Narcotic Phase 2,Phase 1
14 Anti-Inflammatory Agents Phase 2,Phase 1
15 Anti-Inflammatory Agents, Non-Steroidal Phase 2,Phase 1
16 Antirheumatic Agents Phase 2,Phase 1
17 Cyclooxygenase 2 Inhibitors Phase 2
18 Cyclooxygenase Inhibitors Phase 2,Phase 1
19 Peripheral Nervous System Agents Phase 2,Phase 1
20 Hypoglycemic Agents Phase 2
21 Retinamide Phase 2
22 Ketorolac Tromethamine Phase 2
23 Pharmaceutical Solutions Phase 1, Phase 2
24 Dihematoporphyrin Ether Phase 2
25 Ether Phase 2
26 Hematoporphyrin Derivative Phase 2
27 Hematoporphyrins Phase 2
28 Tea Nutraceutical Phase 2
29
Aspirin Approved, Vet_approved Phase 1 50-78-2 2244
30 Antipyretics Phase 1
31 Fibrinolytic Agents Phase 1
32 Platelet Aggregation Inhibitors Phase 1
33
Heparin Approved, Investigational 9005-49-6 772 46507594
34
Dapsone Approved, Investigational 80-08-0 2955
35
Nicotine Approved 54-11-5 942 89594
36
Sulindac Approved 38194-50-2 5352 1548887
37
Folic Acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
38
leucovorin Approved, Nutraceutical 58-05-9 54575, 6560146 143
39 Acyclovir
40 Anti-Infective Agents
41 Antiviral Agents
42 calcium heparin
43 Coagulants
44 Hemostatics
45 Tolonium Chloride
46 Anti-Bacterial Agents
47 Antimalarials
48 Antiparasitic Agents
49 Antiprotozoal Agents
50 Folic Acid Antagonists

Interventional clinical trials:

(show all 33)
id Name Status NCT ID Phase
1 Photodynamic Therapy for Oral Leukoplakia and Erythroleukoplakia Completed NCT00155337 Phase 4
2 Photodynamic Therapy for Oral Precursor Lesions Completed NCT01497951 Phase 3
3 Celecoxib in Preventing Cancer in Patients With Oral Leukoplakia and/or Head and Neck Dysplasia Unknown status NCT00052611 Phase 2
4 Rosiglitazone Maleate in Treating Patients With Oral Leukoplakia Completed NCT00369174 Phase 2
5 Fenretinide in Treating Patients With Leukoplakia of the Mouth Completed NCT00004161 Phase 2
6 Pioglitazone Hydrochloride in Preventing Head and Neck Cancer in Patients With Oral Leukoplakia Completed NCT00099021 Phase 2
7 Randomized, Double Blind, Placebo-Controlled, Phase IIB Trial of Ketorolac Mouth Rinse Evaluating the Effect of Cyclooxygenase Inhibition on Oropharyngeal Leukoplakia: Collaborative Study of the NCI, NIDCD and the NIDCR Completed NCT00001698 Phase 2
8 Bowman-Birk Inhibitor Concentrate in Preventing Cancer in Patients With Oral Leukoplakia Completed NCT00330382 Phase 2
9 Celecoxib in Preventing Head and Neck Cancer in Patients With Oral Leukoplakia Completed NCT00101335 Phase 2
10 Treatment of Oral Premalignant Lesions With 5-ALA PDT Completed NCT00571974 Phase 1, Phase 2
11 Photodynamic Therapy With Porfimer Sodium in Treating Patients With Precancerous Lesions, Cancer, or Other Disease of the Aerodigestive Tract Completed NCT00453336 Phase 2
12 Metformin Hydrochloride in Preventing Oral Cancer in Patients With an Oral Premalignant Lesion Recruiting NCT02581137 Phase 2
13 A Phase II Trial to Assess the Effects of Green Tea in Oral Leukoplakia Terminated NCT00176566 Phase 2
14 Pioglitazone for Oral Premalignant Lesions Terminated NCT00951379 Phase 2
15 Aspirin Mouthwash in Treating Patients With Oral Leukoplakia Completed NCT01238185 Phase 1
16 Photodynamic Therapy Using Aminolevulinic Acid in Treating Patients With Oral Leukoplakia Terminated NCT00571558 Phase 1
17 Least Invasive Nonlinear Light Microscopy Unknown status NCT00767442
18 Infectious Aetiology of Potentially Malignant Disorders and Squamous Cell Carcinomas of the Oral Cavity Unknown status NCT01636544
19 Treatment and Suppression of Hairy Leukoplakia in ARC Patients With Oral Acyclovir (ACV) Completed NCT00002026
20 Biomarkers for Oral Cancer Completed NCT00341497
21 Comparison or Rose Bengal and Toluidine Blue Staining for Lesion Detection Efficacy Completed NCT03031899
22 Natural History of Oro-pharyngeal Cancer Precursors Completed NCT00179361
23 Dapsone 100 Mg Versus 50 as Primary Prophylaxis for Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS-Related Complex (ARC) Completed NCT00002043
24 A Study of the Association of Sleep Dysfunction and Burning Mouth Syndrome Completed NCT00862576
25 Clinical Research Core Dental Screening Protocol Completed NCT00090818
26 Methylation of p16 CpG Island And Malignant Transformation of Oral Epithelial Dysplasia Completed NCT00835341
27 Salivary and Serum Levels of Chemerin and MMP-9 in Oral Premalignant and Malignant Lesions Completed NCT02323672
28 A Single Center Randomized Controlled Trial Assessing Pain and Quality of Life Following Surgery Recruiting NCT01355926
29 Cancer in Inherited Bone Marrow Failure Syndromes Recruiting NCT00027274
30 Tobacco Cessation Intervention Study for Oral Diseases Recruiting NCT02737176
31 Fluorescence & Reflectance Imaging to Detect Oral Neoplasia Recruiting NCT00542373
32 International Pachyonychia Congenita Research Registry Recruiting NCT02321423
33 A Randomized Study of Sulindac in Oral Premalignant Lesions Active, not recruiting NCT00299195

Search NIH Clinical Center for Leukoplakia

Genetic Tests for Leukoplakia

Anatomical Context for Leukoplakia

MalaCards organs/tissues related to Leukoplakia:

39
Tongue, T Cells, Testes, Liver, Prostate, Endothelial, Myeloid

Publications for Leukoplakia

Articles related to Leukoplakia:

(show top 50) (show all 862)
id Title Authors Year
1
Treatment outcome of vocal cord leukoplakia by transoral laser microsurgery. ( 27686889 )
2017
2
Serial in-office laser treatment of vocal fold leukoplakia: Disease control and voice outcomes. ( 28083976 )
2017
3
Association between smoking, glycemia, blood lipoproteins, and risk of oral leukoplakia. ( 27219072 )
2016
4
ORAL IDIOPATHIC HOMOGENEOUS LEUKOPLAKIA. ( 27323602 )
2016
5
The role of narrow-band imaging (NBI) endoscopy in optical biopsy of vocal cord leukoplakia. ( 27515705 )
2016
6
High-risk oral leukoplakia is associated with aberrant promoter methylation of multiple genes. ( 27255271 )
2016
7
Signal regulatory protein I+ associated with the progression of oral leukoplakia and oral squamous cell carcinoma regulates phenotype switch of macrophages. ( 27793032 )
2016
8
Low expression of angiotensinogen and dipeptidyl peptidase 1 in saliva of patients with proliferative verrucous leukoplakia. ( 27900324 )
2016
9
LAMC2 is a predictive marker for the malignant progression of leukoplakia. ( 27529842 )
2016
10
Proliferative verrucous leukoplakia: An update. ( 27461595 )
2016
11
A study of Ki-67 expression and its clinicopathological determinants in nondysplastic oral leukoplakia. ( 27994417 )
2016
12
Retrospective analysis of the clinical behavior of oral hairy leukoplakia in 215 HIV-seropositive patients. ( 27901200 )
2016
13
Successful treatment of proliferative verrucous leukoplakia with 5% topical imiquimod. ( 27647537 )
2016
14
Cryosurgery with refrigerant gas as a therapeutic option for the treatment of leukoplakia: a case report. ( 27814257 )
2016
15
Resolution of vocal fold leukoplakia during erlotinib treatment for lung cancer. ( 26930330 )
2016
16
A Novel Mutation in the DNA Binding Domain of NFKB is Associated with Speckled Leukoplakia. ( 27510021 )
2016
17
p53 and ki67 as biomarkers in determining response to chemoprevention for oral leukoplakia. ( 27605086 )
2016
18
Immunohistochemical Evaluation of Mast Cells in Leukoplakia and Oral Squamous Cell Carcinoma. ( 27656549 )
2016
19
MicroRNAs-208b-3p, 204-5p, 129-2-3p and 3065-5p as predictive markers of oral leukoplakia that progress to cancer. ( 27508095 )
2016
20
Web-based information on the treatment of oral leukoplakia - quality and readability. ( 27233229 )
2016
21
Dyskeratosis congenita associated with leukoplakia of the tongue. ( 26778687 )
2016
22
Interventions for treating oral leukoplakia to prevent oral cancer. ( 27471845 )
2016
23
The presence of Helicobacter pylori in oral cavities of patients with leukoplakia and oral lichen planus. ( 27008253 )
2016
24
Genetic Abnormalities in Oral Leukoplakia and Oral Cancer Progression. ( 27356725 )
2016
25
Human MutL homolog 1 immunoexpression in oral leukoplakia and oral squamous cell carcinoma: A prospective study in Indian population. ( 27721611 )
2016
26
Cancer-associated fibroblasts are an infrequent finding in the microenvironment of proliferative verrucous leukoplakia-associated squamous cell carcinoma. ( 27681951 )
2016
27
Oral Leukoplakia: Clinicopathological Correlation and Its Relevance to Regional Tobacco-related Habit Index. ( 27595730 )
2016
28
The development of proliferative verrucous leukoplakia in oral lichen planus. A preliminary study. ( 27031060 )
2016
29
Candida infection in oral leukoplakia: an unperceived public health problem. ( 27538681 )
2016
30
Immunohistochemical Expression of Podoplanin in Clinical Variants of Oral Leukoplakia and Its Correlation With Epithelial Dysplasia. ( 27153448 )
2016
31
A Randomized Double-Blind Placebo-Controlled Phase IIB Trial of Curcumin in Oral Leukoplakia. ( 27267893 )
2016
32
Prevalence of Carcinomatous Foci in Oral Leukoplakia: A Clinicopathologic Study of 546 Indian Samples. ( 27656569 )
2016
33
Changes in the salivary microbiota of oral leukoplakia and oral cancer. ( 27026576 )
2016
34
Immunohistochemical Study of TGF-I^1 in Oral Leukoplakia and Oral Squamous Cell Carcinoma: Correlations Between Clinicopathologic Factors and Overall Survival. ( 26990749 )
2016
35
A proteomic approach to compare saliva from individuals with and without oral leukoplakia. ( 27478070 )
2016
36
Salivary mRNA markers having the potential to detect oral squamous cell carcinoma segregated from oral leukoplakia with dysplasia. ( 27263493 )
2016
37
GSTM1 null polymorphism prevalence in tobacco users, oral leukoplakia and oral squamous cell carcinoma patients in South Indian population: A polymerase chain reaction study. ( 27723629 )
2016
38
Oral leukoplakia associated with amalgam restorations. ( 27665986 )
2016
39
Classification of vocal fold leukoplakia by clinical scoring. ( 26849206 )
2016
40
Proliferative Verrucous Leukoplakia - A Perpetuating Ambiguity. ( 27891495 )
2016
41
Oral leukoplakia treatment with the carbon dioxide laser: A systematic review of the literature. ( 26920045 )
2016
42
Phonosurgical resection using submucosal infusion technique for precancerous laryngeal leukoplakia. ( 27107249 )
2016
43
Vascular alterations after photodynamic therapy mediated by 5-aminolevulinic acid in oral leukoplakia. ( 28004205 )
2016
44
Associations Among Glutathione S-Transferase T1, M1, and P1 Polymorphisms and the Risk of Oral Leukoplakia. ( 27152506 )
2016
45
Leukoplakia-A Diagnostic and Management Algorithm. ( 27865803 )
2016
46
Semi-quantifiable angiogenesis parameters in association with the malignant transformation of oral leukoplakia. ( 28036153 )
2016
47
Epstein-Barr Virus and Its Association with Oral Hairy Leukoplakia: A Short Review. ( 27047546 )
2016
48
Role of human papilloma virus in oral leukoplakia. ( 27146781 )
2016
49
Immunohistochemical expression of budding uninhibited by benzimidazole related 1 in leukoplakia and oral squamous cell carcinoma. ( 27194865 )
2016
50
Computer aided morphometric analysis of oral leukoplakia and oral squamous cell carcinoma. ( 26983454 )
2016

Variations for Leukoplakia

Copy number variations for Leukoplakia from CNVD:

7 (show all 16)
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 299983 1 197500000 205300000 Gain CAMSAP1L1 Leukoplakia
2 299999 1 222700000 225100000 Gain PARP1 Leukoplakia
3 300051 1 32200000 34400000 Gain KHDRBS1 Leukoplakia
4 300126 10 103000000 104900000 Gain NPM3 Leukoplakia
5 300490 11 70700000 74900000 Gain CHRDL2 Leukoplakia
6 300847 14 23600000 31800000 Gain GMPR2 Leukoplakia
7 300848 14 23600000 31800000 Gain IRF9 Leukoplakia
8 300849 14 23600000 31800000 Gain REC8 Leukoplakia
9 300904 14 90500000 92800000 Copy number BTBD7 Leukoplakia
10 300905 14 90500000 92800000 Gain BTBD7 Leukoplakia
11 303215 2 64000000 70500000 Gain RAB1A Leukoplakia
12 303505 22 30500000 35900000 Gain FBXO7 Leukoplakia
13 303978 5 135400000 139000000 Gain PAIP2 Leukoplakia
14 303979 5 139000000 143100000 Gain HBEGF Leukoplakia
15 304504 7 43300000 46600000 Gain TBRG4 Leukoplakia
16 304704 8 2200000 6200000 Loss CSMD1 Leukoplakia

Expression for Leukoplakia

Search GEO for disease gene expression data for Leukoplakia.

Pathways for Leukoplakia

GO Terms for Leukoplakia

Cellular components related to Leukoplakia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 intermediate filament cytoskeleton GO:0045111 9.33 KRT13 KRT4 KRT8
2 intermediate filament GO:0005882 9.26 KRT1 KRT13 KRT4 KRT8
3 keratin filament GO:0045095 8.92 KRT1 KRT13 KRT4 KRT8

Biological processes related to Leukoplakia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell proliferation GO:0008283 9.46 CYP1A1 DKC1 MKI67 PCNA
2 glutathione metabolic process GO:0006749 9.32 GSTM1 GSTT1
3 glutathione derivative biosynthetic process GO:1901687 9.26 GSTM1 GSTT1
4 keratinization GO:0031424 9.26 KRT1 KRT13 KRT4 KRT8
5 cornification GO:0070268 8.92 KRT1 KRT13 KRT4 KRT8

Molecular functions related to Leukoplakia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 glutathione transferase activity GO:0004364 8.96 GSTM1 GSTT1
2 structural molecule activity GO:0005198 8.92 KRT1 KRT13 KRT4 KRT8

Sources for Leukoplakia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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