MCID: LKP003
MIFTS: 32

Leukoplakia malady

Summaries for Leukoplakia

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Leukoplakia is a condition in which thickened, white patches form on the tongue, gums, inside of the cheek, or sometimes on the outer female genitals. although the sores can vary in appearance, they are usually white or gray; thick; and slightly raised with a hard surface. the condition is thought to be caused by irritation, but the cause is not always known. tobacco is considered to be the main cause of its development in the mouth. most patches are benign, but a small percentage show early signs of cancer. removing the source of irritation may cause the condition to go away, but surgery to remove the sore(s) may be necessary in some cases. last updated: 5/21/2012

MalaCards: Leukoplakia is related to squamous cell carcinoma and lichen planus. An important gene associated with Leukoplakia is DKC1 (dyskeratosis congenita 1, dyskerin), and among its related pathways are Platinum Pathway, Pharmacokinetics/Pharmacodynamics and Aflatoxin B1 metabolism. The compounds estrogen and chi 2 have been mentioned in the context of this disorder. Affiliated tissues include tongue.

Wikipedia:63 Leukoplakia (also termed leucoplakia,leukokeratosis,leukoplasia,idiopathic leukoplakia,idiopathic... more...

Aliases & Classifications for Leukoplakia

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42NIH Rare Diseases, 44Novoseek, 60UMLS
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Aliases & Descriptions:

leukoplakia 42 44 60


Related Diseases for Leukoplakia

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17GeneCards, 18GeneDecks
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Diseases related to Leukoplakia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 203)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma31.1PCNA, IFI27, S100A7, TP63, TNC, MGMT
2lichen planus30.8KRT1
3keratosis30.3KRT1
4papilloma30.2TGFA, IFI27, TP63, PCNA
5oral leukoplakia30.2IFI27, MKI67, PCNA, RARB, KRT1, TP63
6esophageal cancer30.1PCNA, IFI27, TGFA, CYP1A1, RARB
7leukemia29.9RARB, IFI27, GSTM1, GSTT1, CYP1A1, MGMT
8basal cell carcinoma29.9CYP1A1, GSTM3, GSTM1, GSTT1, TP63, MKI67
9sarcoma29.7MKI67, GSTM1, TP63
10myeloid leukemia29.7RARB
11hepatitis29.7GSTT1
12laryngeal squamous cell carcinoma29.7GSTM3, GSTM1, IFI27, MGMT, GSTT1, TP63
13barrett's esophagus29.7CYP1A1, MKI67, TGFA, MGMT
14hepatitis c29.7GSTM1, CYP1A1
15myeloma29.7IFI27
16breast cancer29.7IFI27, TNC, CYP1A1, TGFA
17dermatitis29.7S100A7
18oral mucosa leukoplakia10.5
19candidiasis10.4
20oral submucous fibrosis10.4
21verrucous carcinoma10.4
22oral candidiasis10.4
23esophageal leukoplakia10.3
24laryngitis10.3
25esophagitis10.2
26leukoplakia of penis10.2
27dyskeratosis congenita10.2
28uterine cervix leukoplakia10.2
29leukoplakia of vagina10.2
30hairy tongue10.1
31oral cavity cancer10.1
32periodontitis10.1
33cervical intraepithelial neoplasia10.0MKI67, IFI27
34galactosemia10.0PCNA
35cholesteatoma10.0RARB, TGFA
36laryngeal benign neoplasm10.0GSTT1, MKI67, IFI27, PCNA
37gastritis10.0PCNA, TGFA
38pituitary tumors10.0IFI27, TGFA
39thyroid cancer10.0GSTM1, GSTT1, TNC, RARB
40craniopharyngioma10.0RARB
41psoriasis10.0TGFA, KRT1, S100A7
42actinic keratosis10.0PCNA, TP63
43leiomyoma10.0MKI67, PCNA
44medulloblastoma10.0MGMT
45familial adenomatous polyposis10.0MGMT, RARB
46malignant mesothelioma10.0TP63
47pancreatic cancer10.0PCNA, TNC, TGFA, IFI27, RARB
48brain cancer10.0GSTT1, GSTM1, CYP1A1
49keratoacanthoma10.0MKI67, PCNA
50inverted papilloma10.0PCNA, MKI67, IFI27

Graphical network of the top 20 diseases related to Leukoplakia:



Diseases related to leukoplakia

Clinical Features for Leukoplakia

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Drugs & Therapeutics for Leukoplakia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Leukoplakia

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Anatomical Context for Leukoplakia

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32MalaCards
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MalaCards organs/tissues related to Leukoplakia:

32
Tongue

Animal Models for Leukoplakia or affiliated genes

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Publications for Leukoplakia

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Genetic Variations for Leukoplakia

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Expression for genes affiliated with Leukoplakia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Leukoplakia

Search GEO for disease gene expression data for Leukoplakia.

Pathways for genes affiliated with Leukoplakia

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49PharmGKB, 37NCBI BioSystems Database, 12EMD Millipore, 53Reactome, 29KEGG, 4Cell Signaling Technology
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Compounds for genes affiliated with Leukoplakia

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 2BitterDB, 59Tocris Bioscience
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Compounds related to Leukoplakia according to GeneCards/GeneDecks:

(show top 50)    (show all 101)
idCompoundScoreTop Affiliating Genes
1estrogen4410.9S100A7
2chi 24410.8IFI27, MKI67, GSTM1, GSTT1
3p0034410.8TP63, GSTT1, GSTM1, IFI27, MKI67, TNC
4oxaliplatin44 49 1112.8GSTT1, TGFA, MGMT, GSTM1, CYP1A1
58-oxoguanine4410.8MGMT, PCNA, GSTM1, GSTT1
6p0024410.8MGMT, GSTT1, GSTM1, MKI67, IFI27, TNC
7acetone4410.8MKI67, GSTT1, GSTM1, CYP1A1
8cyclophosphamide44 49 1112.8CYP1A1, GSTM3, GSTT1, MGMT, PCNA, MKI67
9formaldehyde44 2411.8GSTT1, TNC, MGMT, TGFA, CYP1A1, PCNA
10betacarotene4410.8RARB, PCNA, IFI27, GSTM1, CYP1A1
11fulvestrant44 49 28 1113.8MKI67, PCNA, TGFA, CYP1A1
12ascorbic acid44 2411.8GSTT1, GSTM1, CYP1A1, PCNA, MKI67, TNC
13bromodeoxyuridine4410.8IFI27, MKI67, PCNA, KRT1, TP63, TGFA
14mspi4410.8GSTM1, MGMT, CYP1A1, GSTT1
15paraffin4410.8PCNA, TNC, TP63, IFI27, MGMT, TGFA
16gsts4410.8GSTM3, GSTT1, CYP1A1, GSTM1
17paclitaxel44 49 1112.8IFI27, TGFA
18doxorubicin44 49 1112.8TGFA, MGMT, IFI27, GSTT1, GSTM1, MKI67
19mitomycin c4410.8TGFA, PCNA, MKI67, TP63, MGMT
20azathioprine44 49 2 1113.8TGFA, MGMT, PCNA, RARB, GSTM1
21cisplatin44 49 59 1113.8IFI27, MGMT, PCNA, CYP1A1, RARB, GSTM3
22thymidylate4410.8GSTM1, PCNA, MGMT, MKI67, IFI27
23epoxide4410.8GSTM1, CYP1A1, GSTT1, GSTM3
24testosterone44 59 11 2413.8IFI27, CYP1A1, RARB, KRT1, TP63, TGFA
25arginine4410.8TGFA, CYP1A1, MKI67, IFI27, TP63, PCNA
26progesterone44 59 28 11 2414.8TP63, TNC, MGMT, MKI67, PCNA, TGFA
27benzo(a)pyrene4410.8RARB, GSTT1, CYP1A1, GSTM1
281-hydroxypyrene4410.8CYP1A1, GSTM1, GSTT1
29lactate4410.8TGFA, GSTM1, CYP1A1, PCNA, MKI67, MGMT
30norcantharidin4410.7IFI27, MKI67, PCNA
31retinoic acid44 2411.7TNC, TGFA, MGMT, TP63, MKI67, KRT1
32folate4410.7MGMT, GSTM1, GSTT1, TGFA, MKI67
33estradiol44 11 2412.7RARB, CYP1A1, MKI67
34thymidine44 2411.7TGFA, TP63, RARB, MKI67, MGMT, IFI27
35vegf4410.7TP63, CYP1A1, PCNA, MGMT, TNC, IFI27
36diethylnitrosamine4410.7MGMT, TGFA, PCNA
37hematoxylin4410.7KRT1, PCNA, MKI67, TP63
38genistein44 28 59 2 11 2415.6CYP1A1, PCNA, RARB, MGMT, IFI27, TGFA
39steroid4410.6TGFA, IFI27, GSTT1, MKI67, RARB, KRT1
40noradrenochrome44 2411.6GSTT1, GSTM3, GSTM1
41methotrexate44 49 1112.6GSTM1, MKI67, TGFA, PCNA, MGMT
42oligonucleotide4410.6IFI27, GSTT1, RARB, MGMT, TGFA, TNC
435fluorouracil4410.6MKI67, MGMT, TGFA, GSTM1, PCNA
44bpde4410.6CYP1A1, GSTT1, GSTM1
45hydrochloric acid44 2411.6GSTM3, GSTT1, GSTM1
46mnng4410.5MGMT, IFI27, PCNA
47adrenochrome44 2411.4GSTT1, GSTM1, GSTM3
48biotin44 11 2412.4MKI67, KRT1, TGFA, PCNA
498-oxo-dg4410.3PCNA, GSTT1, GSTM1
50tamoxifen44 49 28 1113.1TGFA, CYP1A1, PCNA, MKI67, IFI27

GO Terms for genes affiliated with Leukoplakia

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16Gene Ontology
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Biological processes related to Leukoplakia according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1glutathione derivative biosynthetic processGO:190168710.6GSTT1, GSTM1, GSTM3
2cellular detoxification of nitrogen compoundGO:07045810.6GSTM3, GSTM1
3nitrobenzene metabolic processGO:01891610.6GSTM3, GSTM1
4glutathione metabolic processGO:00674910.5GSTT1, GSTM1, GSTM3
5response to drugGO:04249310.4TGFA, GSTT1, CYP1A1, MGMT
6cell proliferationGO:00828310.4DKC1, MKI67, PCNA, CYP1A1, TGFA
7xenobiotic metabolic processGO:00680510.3GSTT1, GSTM1, GSTM3, CYP1A1
8xenobiotic catabolic processGO:04217810.2GSTM3, GSTM1

Molecular functions related to Leukoplakia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutathione bindingGO:04329510.5GSTM1, GSTM3
2glutathione transferase activityGO:00436410.1GSTT1, GSTM1, GSTM3

Products for genes affiliated with Leukoplakia

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  • Antibodies
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Sources for Leukoplakia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet