Aliases & Classifications for Leukoplakia

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Sources:
41NIH Rare Diseases, 43Novoseek, 60UMLS
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Leukoplakia, Aliases & Descriptions:

Name: Leukoplakia 41 43 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Summaries for Leukoplakia

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NIH Rare Diseases:41 Leukoplakia is a condition in which thickened, white patches form on the tongue, gums, inside of the cheek, or sometimes on the outer female genitals. although the sores can vary in appearance, they are usually white or gray; thick; and slightly raised with a hard surface. the condition is thought to be caused by irritation, but the cause is not always known. tobacco is considered to be the main cause of its development in the mouth. most patches are benign, but a small percentage show early signs of cancer. removing the source of irritation may cause the condition to go away, but surgery to remove the sore(s) may be necessary in some cases. last updated: 5/21/2012

MalaCards based summary: Leukoplakia is related to oral leukoplakia and lichen planus. An important gene associated with Leukoplakia is KRT4 (keratin 4), and among its related pathways are Glutathione metabolism and Platinum Pathway, Pharmacokinetics/Pharmacodynamics. The compounds methylchloride and drugs for treatment of tuberculosis have been mentioned in the context of this disorder. Affiliated tissues include tongue, liver and prostate, and related mouse phenotype homeostasis/metabolism.

Wikipedia:63 Leukoplakia (also termed leucoplakia,leukokeratosis,leukoplasia,idiopathic leukoplakia,idiopathic... more...

Related Diseases for Leukoplakia

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Diseases related to Leukoplakia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 188)
idRelated DiseaseScoreTop Affiliating Genes
1oral leukoplakia31.5MKI67, TP63, GSTM1, RARB, KRT1
2lichen planus31.3KRT13, KRT1
3keratosis31.1KRT1
4papilloma30.8TP63, KRT13
5white sponge nevus 130.6KRT4, KRT13
6esophageal cancer30.0RARB, CYP1A1
7sarcoma29.9MKI67, TP63, GSTM1
8oral cancer29.9CYP1A1, TNC, GSTM1, GSTT1, RARB, KRT13
9leukemia29.6CYP1A1, GSTM1, GSTT1, RARB
10basal cell carcinoma29.3CYP1A1, MKI67, TP63, GSTM1, GSTT1
11breast cancer28.5CYP1A1, MKI67, TNC, TP63, GSTM1, GSTT1
12oral hairy leukoplakia10.8
13oral squamous cell carcinoma10.7
14candidiasis10.5
15oral lichen planus10.5
16oral submucous fibrosis10.5
17oral candidiasis10.5
18actinic keratosis10.4TP63
19dyskeratosis congenita10.4
20esophageal leukoplakia10.4
21erythroplakia10.4
22uterine cervix leukoplakia10.3
23esophagitis10.3
24laryngitis10.3
25inverted papilloma10.3MKI67, KRT13
26bowen syndrome10.3KRT1, MKI67
27benign breast phyllodes tumor10.3TP63, MKI67
28asbestosis10.3GSTM1, GSTT1
29leukoplakia of penis10.3
30leukoplakia of vagina10.3
31senile cataract10.3GSTT1, GSTM1
32mismatch repair cancer syndrome10.3GSTT1, GSTM1
33open-angle glaucoma10.3GSTT1, GSTM1
34cholesteatoma10.2RARB, KRT13
35breast fibroadenoma10.2TP63, MKI67
36cervical squamous cell carcinoma10.2MKI67, TP63
37oral mucosa leukoplakia10.2
38salivary gland adenoid cystic carcinoma10.2TP63, MKI67
39pneumonia10.2GSTM1, CYP1A1
40laryngeal carcinoma10.2MKI67, GSTT1
41aplastic anemia10.2GSTT1, GSTM1
42cleft lip10.2TP63, GSTM1
43barrett esophagus/esophageal adenocarcinoma10.2MKI67, CYP1A1
44neuroendocrine tumor10.1TP63, KRT1
45sarcoma, synovial10.1MKI67, KRT1, KRT13
46bladder cancer, somatic10.1GSTT1, GSTM1, MKI67
47papillary carcinoma10.1MKI67, TP63, RARB
48dyskeratosis congenita, x-linked10.1
49periodontitis10.1
50blindness10.1

Graphical network of the top 20 diseases related to Leukoplakia:



Diseases related to leukoplakia

Symptoms for Leukoplakia

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Drugs & Therapeutics for Leukoplakia

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Drug clinical trials:

Search ClinicalTrials for Leukoplakia

Search NIH Clinical Center for Leukoplakia

Genetic Tests for Leukoplakia

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Anatomical Context for Leukoplakia

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MalaCards organs/tissues related to Leukoplakia:

31
Tongue, Liver, Prostate, Testes, T cells, Bone marrow, Bone, Colon, Salivary gland, Breast, Myeloid, Endothelial

Animal Models for Leukoplakia or affiliated genes

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MGI Mouse Phenotypes related to Leukoplakia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.2KRT1, GSTT1, GSTM1, TP63, TNC, CYP1A1

Publications for Leukoplakia

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Articles related to Leukoplakia:

(show top 50)    (show all 753)
idTitleAuthorsYear
1
Oral leukoplakia - an update. (25553134)
2014
2
Evaluation of serum lipids and lipoproteins as prognosticators in leukoplakia. (25307809)
2014
3
A study of salivary lactate dehydrogenase isoenzyme levels in patients with oral leukoplakia and squamous cell carcinoma by gel electrophoresis method. (25364177)
2014
4
Upregulation of epidermal growth factor receptor 4 in oral leukoplakia. (23492901)
2013
5
Candidal infection in oral leukoplakia: a clinicopathologic study of 396 patients from eastern China. (22683201)
2013
6
Comprehensive SNP scan of DNA repair and DNA damage response genes reveal multiple susceptibility loci conferring risk to tobacco associated leukoplakia and oral cancer. (23437280)
2013
7
Expression of Bak and Bak/Mcl-1 ratio can predict photodynamic therapy outcome for oral verrucous hyperplasia and leukoplakia. (22974427)
2013
8
Plasma zinc antioxidant vitamins, glutathione levels and total antioxidant activity in oral leukoplakia. (22623931)
2012
9
Immunohistochemical evaluation of mast cells and vascular endothelial proliferation in oral precancerous lesion-leukoplakia. (23248463)
2012
10
Prognostic value of DNA ploidy status in patients with oral leukoplakia. (21880540)
2011
11
Clinicopathological features and immunohistochemical expression of p53, Ki-67, Mcm-2 and Mcm-5 in proliferative verrucous leukoplakia. (20412398)
2010
12
Glycogenic acanthosis presenting as leukoplakia on the tongue. (22778105)
2010
13
Oral hairy leukoplakia in HIV-negative patients: report of 10 cases. (19033322)
2010
14
Treatment of oral leukoplakia with carbon dioxide and potassium-titanyl-phosphate lasers: a comparison. (20171477)
2010
15
Human papillomavirus in oral leukoplakia is no prognostic indicator of malignant transformation. (19679058)
2009
16
Gene expression analysis by oligonucleotide microarray in oral leukoplakia. (19220711)
2009
17
Genomic instability and tumor-specific DNA alterations in oral leukoplakias. (19583749)
2009
18
Leukoplakia. (18478786)
2008
19
Prevalence of leukoplakia, oral submucous fibrosis, papilloma and its relation with stress among green marbles mine laborers, India. (18978707)
2008
20
Proliferative verrucous leukoplakia and its progression to oral carcinoma: report of three cases. (17448142)
2007
21
DNA cytometry of oral leukoplakia and oral lichen planus. (15800471)
2005
22
Oral lycopene--an efficacious treatment for oral leukoplakia? (15789046)
2005
23
The results of CO2 laser surgery in patients with oral leukoplakia: a 25 year follow up. (15598583)
2005
24
Dysplastic leukoplakia. (15215492)
2004
25
Polymorphism in CYP1A1 and CYP2E1 genes and susceptibility to leukoplakia in Indian tobacco users. (12767509)
2003
26
Influence of cigarette filters on the risk of developing oral leukoplakia in a Kenyan population. (11355433)
2001
27
Accumulative increase of loss of heterozygosity from leukoplakia to foci of early cancerization in leukoplakia of the oral cavity. (11745290)
2001
28
Plasma HIV-1 RNA and route of transmission in oral candidiasis and oral hairy leukoplakia. (10822365)
2000
29
Oral hairy leukoplakia and oral candidiasis as predictors of HIV viral load. (10546876)
1999
30
Oral leukoplakia status six weeks after cessation of smokeless tobacco use. (10422398)
1999
31
Cytomorphometric analysis of squames obtained from normal oral mucosa and lesions of oral leukoplakia and squamous cell carcinoma. (9526735)
1998
32
Oral hairy leukoplakia in HIV-positive patients. (9486697)
1998
33
Flow cytometric analysis of nuclear DNA content in oral leukoplakia. (9597283)
1998
34
Mutated and wild-type p53 expression and HPV integration in proliferative verrucous leukoplakia and oral squamous cell carcinoma. (9127380)
1997
35
Transforming growth factor-alpha overexpression in proliferative verrucous leukoplakia and oral squamous cell carcinoma: an immunohistochemical study. (8843456)
1996
36
Use of computer-assisted image analysis for noninvasive evaluation of oral lichenoid reactions and oral leukoplakia. (7614184)
1995
37
Time from HIV seroconversion to oral candidiasis or hairy leukoplakia among homosexual and bisexual men enrolled in three prospective cohorts. (8011239)
1994
38
A clinical trial of antioxidant supplements in the treatment of oral leukoplakia. (7800378)
1994
39
Regression of oral leukoplakia with alpha-tocopherol: a community clinical oncology program chemoprevention study. (8416256)
1993
40
Chemoprevention of oral leukoplakia and chronic esophagitis in an area of high incidence of oral and esophageal cancer. (8275193)
1993
41
Epidemiologic study of the association between alcohol habits and oral leukoplakia. (6583042)
1984
42
Leukoplakia of the prepuce with epidermolytic hyperkeratosis: a case report. (6198860)
1983
43
Oral leukoplakia and cryotherapy. (6578814)
1983
44
Scanning electron microscopic study of oral leukoplakia. (6776248)
1980
45
Oral lichen planus, leukoplakia and erythroplakia: some observations on diagnosis and clinical management. (6934472)
1980
46
Esophageal cancer, hyperkeratosis, and oral leukoplakia: follow-up family study. (135097)
1976
47
Comparative cytologic and histologic studies in oral leukoplakia. (1066934)
1976
48
Oral leukoplakia. (4744419)
1973
49
Clinical and histologic study of oral leukoplakia in relation to habits. A five-year follow-up. (5257182)
1969
50
Dyskeratosis congenita with pigmentation, dystrophia unguium, and leukoplakia oris; a follow-up report of two brothers. (13544605)
1958

Variations for Leukoplakia

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Expression for genes affiliated with Leukoplakia

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Search GEO for disease gene expression data for Leukoplakia.

Pathways for genes affiliated with Leukoplakia

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Pathways related to Leukoplakia according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
glutathione-mediated detoxification I36
glutathione redox reactions I36
glutathione redox reactions II36
4-hydroxy-2-nonenal detoxification36
Glutathione metabolism58
Glutathione metabolism36
9.6GSTT1, GSTM1
29.6GSTM1, GSTT1
3
Show member pathways
9.5GSTM1, CYP1A1
49.3KRT1, KRT4, KRT13
5
Show member pathways
9.0GSTT1, GSTM1, CYP1A1
6
Show member pathways
9.0GSTT1, GSTM1, CYP1A1
79.0GSTT1, GSTM1, CYP1A1

Compounds for genes affiliated with Leukoplakia

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Compounds related to Leukoplakia according to GeneCards Suite gene sharing:

(show top 50)    (show all 104)
idCompoundScoreTop Affiliating Genes
1methylchloride4310.0GSTT1, GSTM1
2drugs for treatment of tuberculosis4910.0GSTM1, GSTT1
3n-(2-hydroxyethyl)valine4310.0GSTT1, GSTM1
4trans,trans-muconic acid4310.0GSTT1, GSTM1
5ethambutol49 4310.9GSTM1, GSTT1
6s-phenylmercapturic acid439.9GSTM1, GSTT1
7ethylene oxide439.9GSTM1, GSTT1
8styrene oxide439.9GSTT1, GSTM1
92-naphthol439.9GSTM1, GSTT1
10hema439.8GSTM1, GSTT1
11butadiene monoxide439.8GSTT1, GSTM1
12cumene hydroperoxide439.8GSTM1, GSTT1
131,3-butadiene439.8GSTT1, GSTM1
14isotretinoin43 1210.7RARB, MKI67, KRT1
15chi 2439.7GSTM1, MKI67, GSTT1
16vinylchloride439.7GSTT1, GSTM1
17streptomycin49 43 1211.6GSTT1, GSTM1
18diepoxybutane439.6GSTT1, GSTM1
19pyrazinamide43 49 1211.5GSTT1, GSTM1
20hematoxylin439.5MKI67, TP63, KRT1
21betacarotene439.4CYP1A1, GSTM1, RARB
221-hydroxypyrene439.4CYP1A1, GSTM1, GSTT1
23bpde439.4GSTT1, GSTM1, CYP1A1
24hydrocarbons439.4CYP1A1, GSTT1, GSTM1
25mspi439.4GSTT1, CYP1A1, GSTM1
26gsts439.4CYP1A1, GSTM1, GSTT1
27epoxide439.3CYP1A1, GSTM1, GSTT1
28oxaliplatin43 49 1211.3GSTT1, GSTM1, CYP1A1
29arylamine439.3GSTM1, GSTT1
30alpha tocopherol439.2CYP1A1, RARB, GSTM1
31vitamin a43 24 1211.2GSTM1, RARB, KRT4, CYP1A1
32acetone439.1GSTM1, CYP1A1, GSTT1, MKI67
33cyclophosphamide43 49 1211.1MKI67, GSTM1, GSTT1, CYP1A1
34doxorubicin43 49 1211.1GSTM1, MKI67, TP63, GSTT1
35benzo(a)pyrene439.0CYP1A1, RARB, GSTT1, GSTM1
36proline439.0KRT13, KRT1, MKI67, GSTT1
37ethanol43 49 24 1212.0CYP1A1, GSTT1, RARB, MKI67
38valine438.9GSTM1, KRT1, GSTT1, CYP1A1
39p002438.9MKI67, TNC, GSTT1, GSTM1
40steroid438.7MKI67, TP63, GSTT1, KRT1, RARB
41formaldehyde43 249.6MKI67, GSTT1, TNC, CYP1A1
42p003438.4TP63, GSTM1, MKI67, TNC, GSTT1
43paraffin438.4KRT13, MKI67, TNC, TP63, KRT1
44ascorbic acid43 249.3CYP1A1, MKI67, TNC, GSTM1, GSTT1
45testosterone43 59 24 1211.3CYP1A1, TP63, GSTM1, RARB, KRT1, MKI67
46cisplatin43 49 59 1211.2GSTT1, RARB, MKI67, GSTM1, CYP1A1, TP63
47arginine437.8TP63, KRT1, CYP1A1, MKI67, RARB, GSTM1
48progesterone43 28 59 24 1211.5KRT4, TNC, TP63, RARB, KRT1, CYP1A1
49retinoic acid43 248.1CYP1A1, MKI67, TNC, TP63, RARB, KRT1
50estrogen436.6KRT4, CYP1A1, MKI67, TNC, TP63, GSTM1

GO Terms for genes affiliated with Leukoplakia

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Cellular components related to Leukoplakia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1keratin filamentGO:00450959.3KRT13, KRT4, KRT1

Biological processes related to Leukoplakia according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1glutathione derivative biosynthetic processGO:019016879.7GSTT1, GSTM1
2glutathione metabolic processGO:00067499.6GSTM1, GSTT1
3response to organic cyclic compoundGO:00140709.2GSTT1, MKI67, CYP1A1
4odontogenesis of dentin-containing toothGO:00424759.1TP63, TNC
5xenobiotic metabolic processGO:00068059.1GSTT1, GSTM1, CYP1A1
6cellular response to retinoic acidGO:00713008.9KRT13, TNC
7response to woundingGO:00096118.9TNC, CYP1A1

Molecular functions related to Leukoplakia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1glutathione transferase activityGO:00043649.6GSTT1, GSTM1
2structural molecule activityGO:00051989.0KRT13, KRT4, KRT1

Products for genes affiliated with Leukoplakia

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Sources for Leukoplakia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet