MCID: LKR001
MIFTS: 33

Leukorrhea

Categories: Reproductive diseases

Aliases & Classifications for Leukorrhea

MalaCards integrated aliases for Leukorrhea:

Name: Leukorrhea 12 41 14
Discharge - Leukorrhea 12
Leukorrhea of Vagina 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3766
ICD10 32 N89.8
MeSH 41 D007973
NCIt 46 C34775
UMLS 69 C0023533

Summaries for Leukorrhea

MalaCards based summary : Leukorrhea, also known as discharge - leukorrhea, is related to vaginitis and cervicitis. An important gene associated with Leukorrhea is TNNT1 (Troponin T1, Slow Skeletal Type), and among its related pathways/superpathways are Toxoplasmosis and Toll Comparative Pathway. The drugs Metronidazole and Clindamycin have been mentioned in the context of this disorder. Affiliated tissues include cervix, testes and uterus, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 72 Leukorrhea or (leucorrhoea British English) is a thick, whitish or yellowish vaginal discharge. There... more...

Related Diseases for Leukorrhea

Diseases related to Leukorrhea via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 vaginitis 10.2
2 cervicitis 10.1
3 bacterial vaginosis 10.1
4 vaginal discharge 9.9
5 salpingitis 9.9
6 endocervicitis 9.9
7 stomach disease 9.5 CD79A PTGS2
8 bone inflammation disease 9.4 CD79A PTGS2
9 gastrointestinal system disease 9.3 CD79A PTGS2

Graphical network of the top 20 diseases related to Leukorrhea:



Diseases related to Leukorrhea

Symptoms & Phenotypes for Leukorrhea

GenomeRNAi Phenotypes related to Leukorrhea according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.17 NFKBIA
2 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.17 NFKBIA
3 Increased shRNA abundance (Z-score > 2) GR00366-A-13 9.17 PTGS2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.17 PTGS2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-56 9.17 NFKBIA PTGS2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.17 PTGS2

Drugs & Therapeutics for Leukorrhea

Drugs for Leukorrhea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metronidazole Approved Phase 4,Phase 3 443-48-1 4173
2
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
3 Anti-Bacterial Agents Phase 4,Phase 3
4 Anti-Infective Agents Phase 4,Phase 3
5 Antiparasitic Agents Phase 4,Phase 3
6 Antiprotozoal Agents Phase 4,Phase 3
7 Clindamycin palmitate Phase 4
8 Clindamycin phosphate Phase 4
9
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
10
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
11
Secnidazole Approved Phase 3 3366-95-8
12
Neomycin Approved, Vet_approved Phase 3 1404-04-2 8378
13
Nystatin Approved, Vet_approved Phase 3 1400-61-9 11953884
14
Josamycin Approved, Investigational Phase 3 16846-24-5 5282165
15 Antifungal Agents Phase 3
16 Cytochrome P-450 CYP2C9 Inhibitors Phase 3
17 Cytochrome P-450 Enzyme Inhibitors Phase 3
18 Hormone Antagonists Phase 3
19 Hormones Phase 3
20 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
21 Steroid Synthesis Inhibitors Phase 3
22 Cytochrome P-450 CYP3A Inhibitors Phase 3
23 Ionophores Phase 3
24 Polymyxin B Phase 3
25 Polymyxins Phase 3
26 Antibiotics, Antitubercular Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Efficacy and Safety Study of Clindamycin Palmitate Hydrochloride Dispersible Tablet Treatment of Bacterial Vaginosis Recruiting NCT03080740 Phase 4 Clindamycin palmitate hydrochloride dispersible tablet;Metronidazole Tablet
2 Safety and Clinical and Microbiological Efficacy of the Combination of Fluconazole and Secnidazole for the Treatment of Symptomatic Vaginal Discharge Completed NCT02111629 Phase 3 Fluconazole and Secnidazole
3 Assessment of the Efficacy of POLYGYNAX® in the Empirical Treatment of Infectious Vaginitis Completed NCT02515656 Phase 3 POLYGYNAX®;GYNODAKTARIN®;Placebo
4 Reduction of Spontaneous Prematurity by Antibiotic Treatment (Josamycin) Completed NCT00718705 Phase 3 Josamycin;Placebo
5 A Pilot Study to Evaluate the Safety and Activities of EW02 in Reducing Neutropenia Caused by Chemotherapy Unknown status NCT00555516 Phase 1, Phase 2
6 Cryotherapy for Human Papillomavirus Clearance in Biopsy-confirmed Cervical Low-grade Squamous Intraepithelial Lesions Terminated NCT00566579

Search NIH Clinical Center for Leukorrhea

Cochrane evidence based reviews: leukorrhea

Genetic Tests for Leukorrhea

Anatomical Context for Leukorrhea

MalaCards organs/tissues related to Leukorrhea:

38
Cervix, Testes, Uterus

Publications for Leukorrhea

Articles related to Leukorrhea:

(show all 39)
# Title Authors Year
1
Computerized detection of leukocytes in microscopic leukorrhea images. ( 28555888 )
2017
2
Perceptions and Knowledge about Leukorrhea in a Slum Dwelling South Asian Community. ( 24971133 )
2014
3
Correlation of leukorrhea and Trichomonas vaginalis infection. ( 23678058 )
2013
4
Cervical leukorrhea is correlated with bacterial vaginosis. ( 21315345 )
2011
5
By the way, doctor. I'm a healthy 62-year-old. In the past three months, I've developed a vaginal discharge and discomfort. tests for vaginal infections have been negative. I've tried douching and sitz baths. I started using vaginal estrogen (Premarin) cream about two months ago. Nothing helps. I'd appreciate your thoughts on this problem, which my gynecologist calls "chronic leukorrhea.". ( 20217961 )
2010
6
Patient 60 years old with post menopausal metrorrhagia and fetid leukorrhea. ( 19617161 )
2008
7
Combination of bacterial vaginosis and leukorrhea as a predictor of cervical chlamydial or gonococcal infection. ( 12039120 )
2002
8
Leukorrhea and bacterial vaginosis as in-office predictors of cervical infection in high-risk women. ( 12383553 )
2002
9
Cultural and biomedical meanings of the complaint of leukorrhea in South Asian women. ( 11348516 )
2001
10
Bacteriological study of leukorrhea. ( 6813525 )
1982
11
Corynebacterium vaginale (Haemophilus vaginalis) in women with leukorrhea. ( 984128 )
1976
12
LEUKORRHEA IN THE ADULT FEMALE. ( 14211262 )
1965
13
Hemophilus vaginalis in leukorrhea: incidence, diagnosis, and treatment. ( 13993388 )
1963
14
New relief for leukorrhea. ( 14464077 )
1962
15
Leukorrhea and vaginitis. ( 14494891 )
1961
16
Uterus didelphys presenting as leukorrhea. Report of a case. ( 13695052 )
1961
17
LEUKORRHEA during childhood. ( 13627071 )
1959
18
Leukorrhea; its causes and a new vaginal classification. ( 13668938 )
1959
19
Endamoeba histolytica in leukorrhea and salpingitis. ( 13444376 )
1957
20
Leukorrhea. ( 13394855 )
1957
21
[Gynecological experiences with albothyl; contribution to the colposcopic & cytological control of leukorrhea & erosion of the cervix]. ( 13493441 )
1957
22
Leukorrhea; causes and management. ( 13286644 )
1956
23
Leukorrhea; therapy in the office management. ( 13333451 )
1956
24
Psychosomatic leukorrhea; report of a case. ( 13230917 )
1955
25
Treatment of leukorrhea with douches and broad spectrum therapy. ( 13268014 )
1955
26
The cytolytic changes of the vaginal epithelial cells and the leukorrhea following estrogenic therapy. ( 14388062 )
1955
27
Leukorrhea therapy of 510 cases. ( 14370496 )
1955
28
Acid detergent douche therapy of leukorrhea. ( 13150198 )
1954
29
Leukorrhea. ( 13085113 )
1953
30
The office management of leukorrhea. ( 13016857 )
1953
31
Leukorrhea in general practice; its diagnosis and treatment. ( 12992109 )
1952
32
Chlorophyll, studies on the clinical application and its action in the treatment of leukorrhea vaginalis. ( 13004278 )
1952
33
Chlorophyll; studies on the clinical application and its action in the treatment of leukorrhea vaginalis. ( 13010909 )
1952
34
Leukorrhea of pregnancy; subsequent study of caprokol jelly. ( 15410418 )
1950
35
Leukorrhea, diagnosis and treatment. ( 18152375 )
1949
36
The rational management of leukorrhea. ( 18894219 )
1948
37
Leukorrhea; its causes and treatment. ( 20254969 )
1947
38
Leukorrhea. ( 20255882 )
1947
39
ELECTROTHERMOCAUTERY TREATMENT OF LEUKORRHEA DUE TO ENDOCERVICITIS. ( 18739169 )
1923

Variations for Leukorrhea

Expression for Leukorrhea

Search GEO for disease gene expression data for Leukorrhea.

Pathways for Leukorrhea

GO Terms for Leukorrhea

Biological processes related to Leukorrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 8.62 NFKBIA PTGS2

Sources for Leukorrhea

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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