MCID: LKS001
MIFTS: 45

Leukostasis malady

Summaries for Leukostasis

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64Wikipedia, 33MalaCards
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Wikipedia:64 Leukostasis (aka symptomatic hyperleukocytosis) is a white blood cell count above 100,000/μL. It is... more...

MalaCards: Leukostasis is related to acute leukemia and leukopenia. An important gene associated with Leukostasis is SELE (selectin E), and among its related pathways are Cell adhesion molecules (CAMs) and Signaling by VEGF. The compounds pge2 and okt3 have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, brain and retina, and related mouse phenotypes are vision/eye and no phenotypic analysis.

Aliases & Classifications for Leukostasis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 35MeSH, 40NCIt, 57SNOMED-CT
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Aliases & Descriptions:

leukostasis 8 10 45 61


External Ids:

Disease Ontology8 DOID:12986
MeSH35 D018921
SNOMED-CT57 30419000
NCIt40 C4062

Related Diseases for Leukostasis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Leukostasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 177)
idRelated DiseaseScoreTop Affiliating Genes
1acute leukemia30.7MPO
2leukopenia30.1MPO, C5AR1
3tuberculosis29.9C5AR1, TNF
4retinal ischemia29.9VEGFA
5insulin resistance29.9TNF, AGER, VCAM1, SELE
6granulocytopenia10.3
7acute myeloid leukemia10.2
8central nervous system lymphoma10.1
9central nervous system leukemia10.1
10mantle cell lymphoma10.1
11acute promyelocytic leukemia10.1
12hemorrhage, intracerebral10.1
13acute myocardial infarction10.0SELE
14kawasaki disease10.0SELE
15atopy10.0MPO
16pulmonary fibrosis10.0MPO
17acute pancreatitis10.0MPO
18severe pre-eclampsia10.0VCAM1
19myelodysplastic syndromes10.0MPO
20sjogren's syndrome10.0ICAM1
21pleurisy10.0MPO
22glaucoma10.0SERPINF1
23myeloid leukemia10.0MPO
24bronchiectasis10.0MPO
25myocardial infarction10.0AGER
26polycystic ovary syndrome10.0AGER
27essential hypertension10.0AGER
28dementia10.0AGER
29cataract10.0SERPINF1
30chorioamnionitis10.0TNF
31crohn's disease10.0TNF
32schizophrenia10.0AGER
33ankylosing spondylitis10.0TNF
34macular holes10.0SERPINF1
35hypercholesterolemia10.0VCAM1, SELE
36sarcoma10.0KDR
37nephritis10.0MPO, VCAM1
38sickle cell disease10.0SELE, VCAM1
39wegener's granulomatosis10.0SELE, MPO
40familial mediterranean fever10.0TNF
41antiphospholipid syndrome10.0SELE, VCAM1
42rhinitis10.0ICAM1, VCAM1
43hypertriglyceridemia10.0SELE, VCAM1
44dermatomyositis10.0ICAM1, VCAM1
45thyroid cancer10.0KDR
46interstitial lung disease10.0TNF
47cholera10.0C5AR1
48goodpasture syndrome10.0MPO, VCAM1
49erythema multiforme10.0ICAM1
50pancreatitis10.0MPO, ICAM1

Graphical network of the top 20 diseases related to Leukostasis:



Diseases related to leukostasis

Clinical Features for Leukostasis

Drugs & Therapeutics for Leukostasis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Leukostasis

Drug clinical trials:

Search ClinicalTrials for Leukostasis

Search NIH Clinical Center for Leukostasis

Search CenterWatch for Leukostasis

Genetic Tests for Leukostasis

Anatomical Context for Leukostasis

Sources:
33MalaCards
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MalaCards organs/tissues related to Leukostasis:

33
Bone marrow, Brain, Retina, Lung, Myeloid, Monocytes, T cells, B cells, Endothelial

Animal Models for Leukostasis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Leukostasis

Sources:
51PubMed
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Articles related to Leukostasis:

(show top 50)    (show all 101)
idTitleAuthorsYear
1
Genetic mutations in patients with acute myeloid leukemia and leukostasis. (23548579)
2013
2
CD11b+ bone marrow-derived monocytes are the major leukocyte subset responsible for retinal capillary leukostasis in experimental diabetes in mouse and express high levels of CCR5 in the circulation. (22677420)
2012
3
Hyperleukocytosis, leukostasis and leukapheresis: practice management. (22364832)
2012
4
Rapid treatment of leukostasis in leukemic mantle cell lymphoma using therapeutic leukapheresis: a case report. (22224069)
2011
5
Pazopanib, a multitargeted tyrosine kinase inhibitor, reduces diabetic retinal vascular leukostasis and leakage. (21945644)
2011
6
Therapeutic leukapheresis in patients with leukostasis secondary to acute myelogenous leukemia. (21574176)
2011
7
Pulmonary leukostasis mimicking tuberculosis in endemic area. (20004472)
2010
8
Phosphomannopentaose sulfate (PI-88) inhibits retinal leukostasis in diabetic rat. (19250642)
2009
9
Reliability of leukostasis grading score to identify patients with high-risk hyperleukocytosis. (19391131)
2009
10
Leukostasis and pigment epithelium-derived factor in rat models of diabetic retinopathy. (17653050)
2007
11
Role of NADPH oxidase and ANG II in diabetes-induced retinal leukostasis. (17652361)
2007
12
Images in clinical medicine. FLT3 Mutation and acute myelogenous leukemia with leukostasis. (17942876)
2007
13
Correlation between expression of CD56/NCAM and severe leukostasis in hyperleukocytic acute myelomonocytic leukaemia. (16519701)
2006
14
Case report: mantle cell lymphoma, prolymphocytoid variant, with leukostasis syndrome. (15197401)
2004
15
Pulmonary leukostasis and the inhibition of airway neutrophil recruitment are early events in the endotoxemic rat. (11837792)
2002
16
Effective and selective prevention of retinal leukostasis in streptozotocin-induced diabetic rats using gliclazide. (12107755)
2002
17
Pulmonary leukostasis: role of perfusion lung scan in diagnosis and follow up. (11343387)
2001
18
The irreplaceable image: Cerebral leukostasis manifesting as multifocal intracerebral hemorrhage. (11694415)
2001
19
Pulmonary leukostasis mimicking pulmonary embolism. (10654454)
2000
20
Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition. (10485912)
1999
21
Use of genetically manipulated strains of Clostridium perfringens reveals that both alpha-toxin and theta-toxin are required for vascular leukostasis to occur in experimental gas gangrene. (10456947)
1999
22
T-lymphocytes contribute to hepatic leukostasis and hypoxic stress induced by gut ischemia-reperfusion. (10654278)
1999
23
Transgenic mice with increased copper/zinc-superoxide dismutase activity are resistant to hepatic leukostasis and capillary no-reflow after gut ischemia/reperfusion. (9758638)
1998
24
Hepatic leukostasis and hypoxic stress in adhesion molecule-deficient mice after gut ischemia/reperfusion. (9045883)
1997
25
Pressure-related capillary leukostasis following ischemia-reperfusion and hemorrhagic shock. (8342655)
1993
26
Involvement of the complement system in the pathogenesis of pulmonary leukostasis in experimental myelocytic leukemia. (8412322)
1993
27
Endothelial activation antigens in pulmonary leukostasis in leukemia. (8237271)
1993
28
Increased leukocyte adhesiveness/aggregation and tissue leukostasis following surgical trauma. (8473077)
1993
29
Acute leukostasis pulmonary distress syndrome. (1402733)
1992
30
Pulmonary leukostasis without hyperleukocytosis: a clinicopathologic study of 16 cases. (1566743)
1992
31
Experimental myelocytic leukemia in the Brown-Norway rat as a model for pulmonary leukostasis. (2000946)
1991
32
Pulmonary leukostasis: radiologic-pathologic study. (3479813)
1987
33
High-voltage irradiation and hydroxyurea for pulmonary leukostasis in acute myelomonocytic leukemia. (3113160)
1987
34
Early deaths due to hemorrhage and leukostasis in childhood acute myelogenous leukemia. Associations with hyperleukocytosis and acute monocytic leukemia. (3479232)
1987
35
Aleukaemic leukostasis in a case of large cell non-Hodgkin's lymphoma: report of a case with a distinctive central nervous system involvement. (3760899)
1986
36
Streptococcus pneumoniae-induced alterations in levels of circulating thromboxane and prostacyclin: dissociation from granulocytopenia, thrombocytopenia, and pulmonary leukostasis. (3510262)
1986
37
Leukostasis thrombi. (4009895)
1985
38
Distribution of pneumococcus-induced augmentation of tissue leukostasis in rabbits: specificity for the pulmonary vascular bed. (3973472)
1985
39
Quantitative assessment of leukostasis in experimental hypovolemic-traumatic shock. (6720220)
1984
40
Pneumococcal sonicate-induced biphasic granulocytopenia and its dissociation from pulmonary leukostasis. The contribution of pneumococcal products and complement to early and late granulocytopenic phases. (6644159)
1983
41
Fatal complement-induced leukostasis after diatrizoate injection. Principles of clinicopathologic diagnosis. (6195360)
1983
42
Thromboxane synthesis by sources other than platelets in association with complement-induced pulmonary leukostasis and pulmonary hypertension in sheep. (6687354)
1983
43
Respiratory failure due to pulmonary leukostasis following chemotherapy of acute nonlymphocytic leukemia. (6831346)
1983
44
Respiratory failure due to leukostasis in leukaemia. (6946277)
1981
45
Rapid cytoreduction in acute leukemia. Management of cerebral leukostasis by cell pheresis. (272799)
1978
46
Leukostasis associated with blood transfusion in acute myeloid leukaemia. (273461)
1978
47
Leukostasis in chronic myeloid leukaemia. (277274)
1978
48
Hydroxyurea in the prevention of the effects of leukostasis in acute leukemia. (268956)
1977
49
Hemodialysis leukopenia. Pulmonary vascular leukostasis resulting from complement activation by dialyzer cellophane membranes. (856872)
1977
50
Complement (C5-a)-induced granulocyte aggregation in vitro. A possible mechanism of complement-mediated leukostasis and leukopenia. (874088)
1977

Genetic Variations for Leukostasis

Expression for genes affiliated with Leukostasis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Leukostasis

Search GEO for disease gene expression data for Leukostasis.

Pathways for genes affiliated with Leukostasis

Sources:
30KEGG, 54Reactome, 38NCBI BioSystems Database, 12EMD Millipore, 52QIAGEN
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Compounds for genes affiliated with Leukostasis

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 60Tocris Bioscience, 50PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Leukostasis according to GeneCards/GeneDecks:

(show top 50)    (show all 138)
idCompoundScoreTop Affiliating Genes
1pge24510.3VEGFA
2okt34510.2ICAM1, VCAM1
3triamcinolone acetonide45 2911.2SERPINF1
4matrigel4510.1SELE, KDR
5ulinastatin4510.0MPO, ICAM1
6diphenyleneiodonium459.8SERPINF1, VCAM1, MPO
78 methoxypsoralen459.7SELE, VCAM1, ICAM1
8sele459.7ICAM1, VCAM1, SELE
9prednisolone45 29 1111.7MPO, C5AR1
10troglitazone45 29 60 1112.5SELE, ICAM1, VCAM1
11ro 31-7549459.4TNF, VCAM1, SELE
12cobalt chloride459.4VEGFA, SELE, VCAM1
13hcec459.4KDR, ICAM1, VCAM1
14celastrol45 6010.4SELE, VCAM1, TNF
15slex459.2VCAM1, ICAM1, SELE
16dexamethasone45 50 29 1112.1VEGFA, SERPINF1, KDR
17fluticasone propionate45 50 60 1112.1TNF, MPO, VCAM1, SELE
18polymyxin b459.1SELE, VCAM1, TNF, ICAM1
19groalpha459.1VCAM1, TNF, ICAM1, SELE
20rantes459.1C5AR1, ICAM1, TNF
21sulfasalazine45 29 50 1112.0ICAM1, TNF, MPO, SELE
22budesonide45 50 1111.0VCAM1, MPO, ICAM1, TNF
23fenofibrate45 50 1111.0TNF, ICAM1, VCAM1, SELE
24fluorescein45 1110.0MPO, C5AR1, SERPINF1, VEGFA
25gliclazide45 50 1111.0SELE, VEGFA, MPO, ICAM1, VCAM1
26pdtc459.0VCAM1, TNF, ICAM1, SELE
27pentoxifylline45 119.9ICAM1, MPO, TNF, VCAM1
288-isoprostane458.7SELE, ICAM1, VCAM1, MPO, TNF
29n-formylmethionyl-leucylphenylalanine458.7C5AR1, MPO, ICAM1, TNF
30herbimycin a45 609.7VCAM1, TNF, ICAM1, SELE
31endotoxin458.5ICAM1, C5AR1, SELE, VCAM1, TNF
32atorvastatin45 50 29 11 2412.5TNF, SELE, VEGFA, VCAM1, ICAM1
33fmlp458.5VCAM1, ICAM1, TNF, C5AR1, MPO
34fibrinogen458.4TNF, ICAM1, SELE, C5AR1, VCAM1
35oxygen45 249.3ICAM1, TNF, MPO, SERPINF1, C5AR1
36histamine45 29 2410.2TNF, MPO, VCAM1, SELE, C5AR1, ICAM1
37lactate458.1VCAM1, SELE, ICAM1, TNF, MPO, KDR
38apocynin45 609.1ICAM1, TNF, MPO, VEGFA, VCAM1, SELE
39mg 13245 609.0TNF, ICAM1, VEGFA, KDR
40serine458.0AGER, TNF, C5AR1, SERPINF1, SELE, MPO
41simvastatin45 50 60 29 11 2412.9SELE, ICAM1, TNF, VEGFA, KDR, VCAM1
42sb 20358045 608.9VCAM1, VEGFA, C5AR1, TNF, ICAM1, SELE
43heparin45 29 11 2410.9AGER, C5AR1, VCAM1, SELE, VEGFA, MPO
44ly294002457.9SELE, VCAM1, KDR, VEGFA, TNF, ICAM1
45genistein45 29 60 2 11 2412.9ICAM1, TNF, SELE, VEGFA, KDR, VCAM1
46h2o2457.8TNF, SERPINF1, C5AR1, KDR, MPO, ICAM1
47prostacyclin457.0VCAM1, SELE, C5AR1, KDR, VEGFA, TNF
48nitric oxide45 11 248.8C5AR1, ICAM1, TNF, MPO, AGER, KDR
49n acetylcysteine456.8TNF, VCAM1, SELE, SERPINF1, VEGFA, AGER
50vegf456.2AGER, VCAM1, C5AR1, SELE, SERPINF1, KDR

GO Terms for genes affiliated with Leukostasis

Sources:
16Gene Ontology
See all sources

Cellular components related to Leukostasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membrane raftGO:0451218.7TNF, KDR, SELE
2external side of plasma membraneGO:0098978.5ICAM1, TNF, KDR, VCAM1
3cell surfaceGO:0099868.2C5AR1, VCAM1, VEGFA, TNF
4integral to plasma membraneGO:0058877.5C5AR1, KDR, AGER, TNF, ICAM1
5extracellular spaceGO:0056157.4SERPINF1, SELE, VCAM1, VEGFA, MPO, TNF
6plasma membraneGO:0058867.2TNF, AGER, KDR, VCAM1, SELE, C5AR1

Biological processes related to Leukostasis according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1membrane to membrane dockingGO:02261410.1VCAM1, ICAM1
2positive regulation of leukocyte migrationGO:0026879.8SELE, VEGFA
3leukocyte cell-cell adhesionGO:0071599.8SELE, VCAM1, ICAM1
4heterophilic cell-cell adhesionGO:0071579.8ICAM1, VCAM1, SELE
5positive regulation of receptor internalizationGO:0020929.7VEGFA, SELE
6surfactant homeostasisGO:0431299.6KDR, VEGFA
7positive regulation of positive chemotaxisGO:0509279.6KDR, VEGFA
8positive regulation of focal adhesion assemblyGO:0518949.6VEGFA, KDR
9induction of positive chemotaxisGO:0509309.6VEGFA, AGER
10cell migration involved in sprouting angiogenesisGO:0020429.6KDR, VEGFA
11negative regulation of growth of symbiont in hostGO:0441309.5MPO, TNF
12cellular response to glucose stimulusGO:0713339.5VCAM1, ICAM1
13leukocyte tethering or rollingGO:0509019.4SELE, VCAM1, TNF
14cellular response to vascular endothelial growth factor stimulusGO:0359249.4KDR, VEGFA
15vascular endothelial growth factor receptor signaling pathwayGO:0480109.3VEGFA, KDR
16ovarian follicle developmentGO:0015419.3KDR, VEGFA, ICAM1
17positive regulation of nitric oxide biosynthetic processGO:0454299.3TNF, ICAM1
18positive regulation of protein complex assemblyGO:0313349.3TNF, VEGFA
19regulation of cell shapeGO:0083609.2ICAM1, VEGFA, KDR
20branching morphogenesis of an epithelial tubeGO:0487549.2KDR, VEGFA
21positive regulation of NF-kappaB transcription factor activityGO:0510929.1AGER, TNF, ICAM1
22positive regulation of ERK1 and ERK2 cascadeGO:0703748.9TNF, KDR, C5AR1
23positive regulation of protein phosphorylationGO:0019348.8KDR, VEGFA, TNF
24response to hypoxiaGO:0016668.8VCAM1, VEGFA, TNF
25inflammatory responseGO:0069548.7TNF, AGER, SELE, C5AR1

Molecular functions related to Leukostasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:0048889.3SELE, AGER, ICAM1
2integrin bindingGO:0051789.0VCAM1, KDR, ICAM1

Products for genes affiliated with Leukostasis

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  • Antibodies

Sources for Leukostasis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet