Aliases & Classifications for Leukostasis

MalaCards integrated aliases for Leukostasis:

Name: Leukostasis 12 52 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:12986
MeSH 42 D018921
NCIt 47 C4062
SNOMED-CT 64 30419000
UMLS 69 C0282548

Summaries for Leukostasis

MalaCards based summary : Leukostasis is related to heart lymphoma and focal embolic glomerulonephritis. An important gene associated with Leukostasis is ICAM1 (Intercellular Adhesion Molecule 1), and among its related pathways/superpathways are fMLP Pathway and Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways. Affiliated tissues include lung, brain and myeloid, and related phenotypes are cardiovascular system and cellular

Wikipedia : 72 Leukostasis is an extreme form of leukocytosis (an excess of white blood cells) that is dangerously... more...

Related Diseases for Leukostasis

Diseases related to Leukostasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 111)
id Related Disease Score Top Affiliating Genes
1 heart lymphoma 10.7 ICAM1 VCAM1
2 focal embolic glomerulonephritis 10.6 ICAM1 MPO
3 liver disease 10.6 ICAM1 VCAM1
4 uveitis 10.6 ICAM1 MPO
5 uterine corpus sarcoma 10.5 ICAM1 VCAM1
6 hyperaldosteronism 10.5 ICAM1 VEGFA
7 inhalation anthrax 10.5 MPO VEGFA
8 hodgkin's lymphoma, nodular sclerosis 10.5 ICAM1 SELE
9 cysticercosis 10.5 ICAM1 SELE
10 lichen planus 10.4 ICAM1 VEGFA
11 bardet-biedl syndrome 17 10.4 MPO VEGFA
12 kidney pelvis papillary carcinoma 10.4 KDR VEGFA
13 leukemia 10.4
14 extragonadal germ cell cancer 10.4 KDR VEGFA
15 dentin dysplasia 10.4 ICAM1 VCAM1
16 iliac vein thrombophlebitis 10.4 KDR VEGFA
17 vesiculobullous skin disease 10.4 KDR VEGFA
18 segmental odontomaxillary dysplasia 10.4 KDR VEGFA
19 coloboma of superior eyelid 10.4 KDR VEGFA
20 lens disease 10.3 KDR VEGFA
21 spastic paraplegia 43, autosomal recessive 10.3 SELE VCAM1
22 dracunculiasis 10.3 ICAM1 SELE
23 waterhouse-friderichsen syndrome 10.3 SELE VEGFA
24 angiokeratoma 10.3 ICAM1 MPO VCAM1
25 factitious disorder 10.3 KDR VEGFA
26 posterior foramen magnum meningioma 10.3 KDR VEGFA
27 dislocation of ear ossicle 10.3 ICAM1 MPO VCAM1
28 benign secondary hypertension 10.3 ICAM1 MPO VCAM1
29 arthrogryposis, ectodermal dysplasia, cleft lip/palate, and developmental delay 10.3 KDR VEGFA
30 facial dermatosis 10.3 KDR MPO
31 conduct disorder 10.3 ICAM1 SELE
32 granuloma annulare 10.3 ICAM1 MPO VCAM1
33 pseudohypoaldosteronism, type iid 10.3 ICAM1 MPO VCAM1
34 lobomycosis 10.3 ICAM1 SELE
35 benign familial neonatal epilepsy 10.3 KDR VEGFA
36 neuropathy, hereditary sensory and autonomic, type vi 10.3 ICAM1 VCAM1 VEGFA
37 partial central choroid dystrophy 10.3 MPO SELE
38 retinitis 10.2
39 orbital melanoma 10.2 ICAM1 VCAM1
40 subacute leukemia 10.2 ICAM1 MPO VEGFA
41 congenital diaphragmatic hernia 10.2 ICAM1 SELL
42 lymphomatous thyroiditis 10.2 ICAM1 SELE VCAM1
43 focal dystonia 10.2 VCAM1 VEGFA
44 marginal corneal ulcer 10.2 ICAM1 SELE VCAM1
45 inferolateral myocardial infarct 10.2 ICAM1 SELE VCAM1
46 moved to 244450 10.2 ICAM1 SELE VCAM1
47 tick-borne encephalitis 10.2 ICAM1 SELE
48 riboflavin transporter deficiency 10.2 ICAM1 SELE VCAM1
49 dysphagia 10.2 ICAM1 SELE VCAM1
50 synovium cancer 10.1 ICAM1 SELE VCAM1

Graphical network of the top 20 diseases related to Leukostasis:



Diseases related to Leukostasis

Symptoms & Phenotypes for Leukostasis

MGI Mouse Phenotypes related to Leukostasis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.01 VCAM1 VEGFA ICAM1 KDR MPO NFATC4
2 cellular MP:0005384 9.97 ICAM1 KDR NFATC2 NFATC4 SELE SELL
3 growth/size/body region MP:0005378 9.92 SELL VCAM1 VEGFA ICAM1 KDR NFATC2
4 hematopoietic system MP:0005397 9.91 ICAM1 KDR MPO NFATC2 NFATC4 SELE
5 immune system MP:0005387 9.76 ICAM1 KDR MPO NFATC2 SELE SELL
6 muscle MP:0005369 9.43 ICAM1 KDR MPO NFATC2 NFATC4 VEGFA
7 respiratory system MP:0005388 9.02 KDR NFATC2 SELE SELL VEGFA

Drugs & Therapeutics for Leukostasis

Search Clinical Trials , NIH Clinical Center for Leukostasis

Cochrane evidence based reviews: leukostasis

Genetic Tests for Leukostasis

Anatomical Context for Leukostasis

MalaCards organs/tissues related to Leukostasis:

39
Lung, Brain, Myeloid, Endothelial, Neutrophil, Monocytes, Bone

Publications for Leukostasis

Articles related to Leukostasis:

(show top 50) (show all 119)
id Title Authors Year
1
Is leukostasis a crucial step or epiphenomenon in the pathogenesis of diabetic retinopathy? ( 28724696 )
2017
2
Targeting of 12/15-Lipoxygenase in retinal endothelial cells, but not in monocytes/macrophages, attenuates high glucose-induced retinal leukostasis. ( 28351645 )
2017
3
Curcumolide reduces diabetic retinal vascular leukostasis and leakage partly via inhibition of the p38MAPK/NF-I_ B signaling. ( 28274631 )
2017
4
Comparing leukapheresis protocols for an AML patient with symptomatic leukostasis. ( 28940295 )
2017
5
Pulmonary Leukostasis: Treatment When Cytoreduction Does Not Suffice. ( 28060107 )
2017
6
miR-15a/16 reduces retinal leukostasis through decreased pro-inflammatory signaling. ( 27931222 )
2016
7
Leukostasis in adult acute hyperleukocytic leukemia: a clinician's digest. ( 27018197 )
2016
8
Hyperleukocytosis and leukostasis: management of a medical emergency. ( 27967252 )
2016
9
Exchange Transfusion and Leukapheresis in Pediatric Patients with AML With High Risk of Early Death by Bleeding and Leukostasis. ( 26670831 )
2016
10
Leukostasis Retinopathy: A New Clinical Manifestation of Chronic Myeloid Leukemia With Severe Hyperleukocytosis. ( 26247460 )
2015
11
Leukostasis in Children and Adolescents with Chronic Myeloid Leukemia: Japanese Pediatric Leukemia/Lymphoma Study Group. ( 26485422 )
2015
12
NFAT isoforms play distinct roles in TNFI+-induced retinal leukostasis. ( 26527057 )
2015
13
How we approach a patient with symptoms of leukostasis requiring emergent leukocytapheresis. ( 26267387 )
2015
14
Pulmonary leukostasis with severe respiratory impairment as a debut of acute myeloid leukemia. ( 26157660 )
2015
15
Transfusion medicine illustrated. Catastrophic basilar artery leukostasis in the setting of acute myeloid leukemia. ( 24724788 )
2014
16
Pathologic rupture of the spleen in a patient with acute myelogenous leukemia and leukostasis. ( 25031169 )
2014
17
The effect of puerarin against IL-1I^-mediated leukostasis and apoptosis in retinal capillary endothelial cells (TR-iBRB2). ( 25593509 )
2014
18
Genetic mutations in patients with acute myeloid leukemia and leukostasis. ( 23548579 )
2013
19
Leukostasis in an Adult with AML Presenting as Multiple High Attenuation Brain Masses on CT. ( 24551717 )
2013
20
Intra-ophthalmic artery chemotherapy triggers vascular toxicity through endothelial cell inflammation and leukostasis. ( 22427570 )
2012
21
CD11b+ bone marrow-derived monocytes are the major leukocyte subset responsible for retinal capillary leukostasis in experimental diabetes in mouse and express high levels of CCR5 in the circulation. ( 22677420 )
2012
22
Hyperleukocytosis, leukostasis and leukapheresis: practice management. ( 22364832 )
2012
23
Therapeutic leukapheresis in patients with leukostasis secondary to acute myelogenous leukemia. ( 21574176 )
2011
24
TNFalpha is required for late BRB breakdown in diabetic retinopathy, and its inhibition prevents leukostasis and protects vessels and neurons from apoptosis. ( 21212173 )
2011
25
Rapid treatment of leukostasis in leukemic mantle cell lymphoma using therapeutic leukapheresis: a case report. ( 22224069 )
2011
26
Pazopanib, a multitargeted tyrosine kinase inhibitor, reduces diabetic retinal vascular leukostasis and leakage. ( 21945644 )
2011
27
Reversal of leukostasis-related pulmonary distress syndrome after leukapheresis and low-dose chemotherapy in acute myeloid leukemia. ( 21825265 )
2011
28
Pulmonary leukostasis mimicking tuberculosis in endemic area. ( 20004472 )
2010
29
Reliability of leukostasis grading score to identify patients with high-risk hyperleukocytosis. ( 19391131 )
2009
30
Targeting leukostasis for the treatment of early diabetic retinopathy. ( 19619127 )
2009
31
Phosphomannopentaose sulfate (PI-88) inhibits retinal leukostasis in diabetic rat. ( 19250642 )
2009
32
Images in clinical medicine. FLT3 Mutation and acute myelogenous leukemia with leukostasis. ( 17942876 )
2007
33
Inhibition of diabetic leukostasis and blood-retinal barrier breakdown with a soluble form of a receptor for advanced glycation end products. ( 17251488 )
2007
34
Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood-retinal barrier breakdown in diabetic retinopathy. ( 17962481 )
2007
35
TNF-alpha is critical for ischemia-induced leukostasis, but not retinal neovascularization nor VEGF-induced leakage. ( 17107717 )
2007
36
A case report of therapeutic leukapheresis in an adult with chronic myelogenous leukemia presenting with hyperleukocytosis and leukostasis. ( 17381536 )
2007
37
Role of NADPH oxidase and ANG II in diabetes-induced retinal leukostasis. ( 17652361 )
2007
38
Leukostasis and pigment epithelium-derived factor in rat models of diabetic retinopathy. ( 17653050 )
2007
39
Hyperleukocytosis associated pulmonary leukostasis in acute leukaemia. ( 16909741 )
2006
40
Role of angiotensin II in retinal leukostasis in the diabetic rat. ( 16822509 )
2006
41
Correlation between expression of CD56/NCAM and severe leukostasis in hyperleukocytic acute myelomonocytic leukaemia. ( 16519701 )
2006
42
Pigment epithelium-derived factor (PEDF) prevents diabetes- or advanced glycation end products (AGE)-elicited retinal leukostasis. ( 16797605 )
2006
43
Intravitreal injection of corticosteroid attenuates leukostasis and vascular leakage in experimental diabetic retina. ( 15790913 )
2005
44
Grading of symptoms in hyperleukocytic leukaemia: a clinical model for the role of different blast types and promyelocytes in the development of leukostasis syndrome. ( 15876254 )
2005
45
Management of life-threatening pulmonary leukostasis with single agent imatinib mesylate during CML myeloid blast crisis. ( 15377482 )
2004
46
Case report: mantle cell lymphoma, prolymphocytoid variant, with leukostasis syndrome. ( 15197401 )
2004
47
The role of advanced glycation end products in retinal microvascular leukostasis. ( 14507893 )
2003
48
Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes: role of oxidants and protein kinase-C activation. ( 12606527 )
2003
49
Cerebrovascular nodules in a patient with leukostasis. ( 12385403 )
2002
50
Effective and selective prevention of retinal leukostasis in streptozotocin-induced diabetic rats using gliclazide. ( 12107755 )
2002

Variations for Leukostasis

Expression for Leukostasis

Search GEO for disease gene expression data for Leukostasis.

Pathways for Leukostasis

Pathways related to Leukostasis according to GeneCards Suite gene sharing:

(show all 30)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.76 KDR NFATC2 NFATC4 VEGFA
2
Show member pathways
12.45 ICAM1 KDR VCAM1 VEGFA
3
Show member pathways
12.37 KDR NFATC2 NFATC4 VEGFA
4 12.32 MPO NFATC2 NFATC4 VCAM1
5
Show member pathways
12.21 ICAM1 NFATC2 NFATC4 VCAM1
6 12.2 ICAM1 NFATC2 NFATC4 VCAM1
7
Show member pathways
11.95 ICAM1 KDR VCAM1
8
Show member pathways
11.94 ICAM1 KDR SELE VCAM1 VEGFA
9 11.89 ICAM1 SELL VCAM1
10 11.88 KDR VCAM1 VEGFA
11 11.83 ICAM1 SELE SELL VCAM1
12 11.8 ICAM1 VCAM1 VEGFA
13 11.76 ICAM1 SELE VCAM1
14 11.62 ICAM1 SELE VCAM1 VEGFA
15 11.34 ICAM1 SELE VCAM1
16 11.31 KDR VEGFA
17 11.3 NFATC2 NFATC4 VEGFA
18 11.29 ICAM1 VCAM1
19 11.28 NFATC2 NFATC4
20
Show member pathways
11.26 KDR VEGFA
21 11.26 ICAM1 SELE VCAM1
22 11.22 SELE SELL
23 11.19 NFATC2 NFATC4
24 11.16 ICAM1 KDR SELE VCAM1 VEGFA
25 11.15 KDR VEGFA
26 11.12 ICAM1 SELE VCAM1
27
Show member pathways
11.06 ICAM1 SELE VCAM1 VEGFA
28 10.99 KDR VEGFA
29 10.82 VCAM1 VEGFA
30 10.64 ICAM1 MPO VCAM1

GO Terms for Leukostasis

Cellular components related to Leukostasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.33 ICAM1 SELL VCAM1
2 membrane raft GO:0045121 9.13 ICAM1 KDR SELE
3 cell surface GO:0009986 8.92 ICAM1 SELL VCAM1 VEGFA

Biological processes related to Leukostasis according to GeneCards Suite gene sharing:

(show all 22)
id Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.89 ICAM1 SELE SELL VCAM1
2 leukocyte migration GO:0050900 9.77 ICAM1 SELE SELL
3 extracellular matrix organization GO:0030198 9.74 ICAM1 KDR VCAM1
4 regulation of immune response GO:0050776 9.73 ICAM1 SELL VCAM1
5 response to hypoxia GO:0001666 9.7 ICAM1 VCAM1 VEGFA
6 regulation of cell shape GO:0008360 9.67 ICAM1 KDR VEGFA
7 ovarian follicle development GO:0001541 9.61 ICAM1 VEGFA
8 negative regulation of endothelial cell apoptotic process GO:2000352 9.58 ICAM1 KDR
9 branching involved in blood vessel morphogenesis GO:0001569 9.58 NFATC4 VEGFA
10 positive regulation of focal adhesion assembly GO:0051894 9.55 KDR VEGFA
11 positive regulation of receptor internalization GO:0002092 9.54 SELE VEGFA
12 calcium-mediated signaling using intracellular calcium source GO:0035584 9.51 KDR VCAM1
13 cell migration involved in sprouting angiogenesis GO:0002042 9.48 KDR VEGFA
14 leukocyte tethering or rolling GO:0050901 9.46 SELE VCAM1
15 response to lipopolysaccharide GO:0032496 9.46 ICAM1 MPO SELE VCAM1
16 positive regulation of positive chemotaxis GO:0050927 9.43 KDR VEGFA
17 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.43 ICAM1 SELE VCAM1
18 calcineurin-NFAT signaling cascade GO:0033173 9.4 NFATC2 NFATC4
19 membrane to membrane docking GO:0022614 9.37 ICAM1 VCAM1
20 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.32 KDR VEGFA
21 leukocyte cell-cell adhesion GO:0007159 9.13 ICAM1 SELE VCAM1
22 cellular response to vascular endothelial growth factor stimulus GO:0035924 8.8 KDR VCAM1 VEGFA

Molecular functions related to Leukostasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 9.13 MPO SELL VEGFA
2 integrin binding GO:0005178 8.8 ICAM1 KDR VCAM1

Sources for Leukostasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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