Aliases & Classifications for Leukostasis

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Aliases & Descriptions for Leukostasis:

Name: Leukostasis 11 50 39 13 68

Classifications:



External Ids:

Disease Ontology11 DOID:12986
MeSH39 D018921
SNOMED-CT62 30419000
NCIt45 C4062

Summaries for Leukostasis

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Wikipedia:71 Leukostasis is an extreme form of leukocytosis (an excess of white blood cells) that is dangerously... more...

MalaCards based summary: Leukostasis is related to overnutrition and west nile fever, and has symptoms including cachexia, cancer pain and tumor pain. An important gene associated with Leukostasis is ICAM1 (Intercellular Adhesion Molecule 1), and among its related pathways are Immune response_MIF-mediated glucocorticoid regulation and Immune response_Role of integrins in NK cells cytotoxicity. Affiliated tissues include lung, brain and myeloid, and related mouse phenotypes are muscle and respiratory system.

Related Diseases for Leukostasis

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Diseases related to Leukostasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 102)
idRelated DiseaseScoreTop Affiliating Genes
1overnutrition10.5ICAM1, VCAM1
2west nile fever10.5ICAM1, VCAM1
3arteriolosclerosis10.5ICAM1, VCAM1
4liver disease10.4ICAM1, VCAM1
5hereditary renal cell carcinoma10.4ICAM1, VEGFA
6dentin dysplasia10.4ICAM1, VCAM1
7leukemia10.4
8parasitic helminthiasis infectious disease10.4ICAM1, SELE
9peripheral scars of retina10.4ICAM1, SELE
10speech disorder10.3ICAM1, VEGFA
11cysticercosis10.3ICAM1, SELE
12labyrinthine bilateral reactive loss10.2ICAM1, SELE
13intracranial primitive neuroectodermal tumor10.2ICAM1, MPO, VCAM1
14uveitis10.2ICAM1, MPO, VCAM1
15retinitis10.2
16bladder urachal carcinoma10.2KDR, VEGFA
17silicosiderosis10.2KDR, VEGFA
18malignant gastric germ cell tumor10.2KDR, VEGFA
19neuropathy, hereditary sensory and autonomic, type vi10.2ICAM1, VCAM1, VEGFA
20arthrogryposis, ectodermal dysplasia, cleft lip/palate, and developmental delay10.2KDR, VEGFA
21epidermolysis bullosa10.2KDR, VEGFA
22iliac vein thrombophlebitis10.2KDR, VEGFA
23calcaneonavicular coalition10.2KDR, VEGFA
24acute porphyria10.1KDR, MPO
25ocular melanoma10.1KDR, VEGFA
26gastric small cell carcinoma10.1KDR, VEGFA
27phagocyte bactericidal dysfunction10.1ICAM1, MPO, VEGFA
28hordeolum externum10.1VCAM1, VEGFA
29perivascular epithelioid cell tumor10.1KDR, VEGFA
30shwartzman phenomenon10.1ICAM1, SELL
31lymphomatoid papulosis10.1ICAM1, SELE, VCAM1
32marginal corneal ulcer10.1ICAM1, SELE, VCAM1
33rhizomelic pseudopolyarthritis10.1ICAM1, SELE, VCAM1
34posterolateral myocardial infarction10.1ICAM1, SELE, VCAM1
35spastic paraplegia-paget disease of bone syndrome10.1ICAM1, SELE, VCAM1
36lens disease10.1KDR, VEGFA
37dementia - subcortical10.1ICAM1, SELE, VCAM1
38chromoblastomycosis10.1ICAM1, MPO, SELE
39iron metabolism disease10.1ICAM1, SELE, VCAM1
40littre gland carcinoma10.1ICAM1, SELE, VCAM1
41angioedema10.1ICAM1, SELL
42myeloid leukemia10.1
43intraneural perineurioma10.0ICAM1, SELE, VEGFA
44epidural abscess10.0KDR, VEGFA
45developmental coordination disorder10.0ICAM1, SELE, VEGFA
46hyperinsulinism10.0KDR, VEGFA
47angina pectoris10.0SELE, VCAM1, VEGFA
48granulocytopenia10.0
49lipoatrophy with diabetes, leukomelanodermic papules, liver steatosis, and hypertrophic cardiomyopathy10.0KDR, VEGFA
50wissler's syndrome10.0ICAM1, SELE

Graphical network of the top 20 diseases related to Leukostasis:



Diseases related to leukostasis

Symptoms & Phenotypes for Leukostasis

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UMLS symptoms related to Leukostasis:


cachexia, cancer pain, tumor pain, metastatic pain, psychomotor skills impaired, breakthrough pain

MGI Mouse Phenotypes related to Leukostasis according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.5ICAM1, KDR, MPO, NFATC2, NFATC4, VEGFA
2MP:00053888.3KDR, NFATC2, SELE, SELL, VEGFA
3MP:00053918.1ICAM1, KDR, NFATC2, SELE, VEGFA
4MP:00053857.5ICAM1, KDR, MPO, NFATC4, SELE, SELL
5MP:00053877.3ICAM1, KDR, MPO, NFATC2, SELE, SELL
6MP:00053847.3ICAM1, KDR, NFATC2, NFATC4, SELE, SELL
7MP:00053787.3ICAM1, KDR, NFATC2, NFATC4, SELE, SELL
8MP:00053976.9ICAM1, KDR, MPO, NFATC2, NFATC4, SELE

Drugs & Therapeutics for Leukostasis

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Leukostasis


Cochrane evidence based reviews: leukostasis

Genetic Tests for Leukostasis

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Anatomical Context for Leukostasis

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MalaCards organs/tissues related to Leukostasis:

36
Lung, Brain, Myeloid, Endothelial, Neutrophil, Monocytes, Bone

Publications for Leukostasis

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Articles related to Leukostasis:

(show top 50)    (show all 115)
idTitleAuthorsYear
1
Pulmonary Leukostasis: Treatment When Cytoreduction Does Not Suffice. (28060107)
2017
2
miR-15a/16 reduces retinal leukostasis through decreased pro-inflammatory signaling. (27931222)
2016
3
Exchange Transfusion and Leukapheresis in Pediatric Patients with AML With High Risk of Early Death by Bleeding and Leukostasis. (26670831)
2016
4
Leukostasis in adult acute hyperleukocytic leukemia: a clinician's digest. (27018197)
2016
5
Hyperleukocytosis and leukostasis: management of a medical emergency. (27967252)
2016
6
Leukostasis Retinopathy: A New Clinical Manifestation of Chronic Myeloid Leukemia With Severe Hyperleukocytosis. (26247460)
2015
7
How we approach a patient with symptoms of leukostasis requiring emergent leukocytapheresis. (26267387)
2015
8
Pulmonary leukostasis with severe respiratory impairment as a debut of acute myeloid leukemia. (26157660)
2015
9
NFAT isoforms play distinct roles in TNFI+-induced retinal leukostasis. (26527057)
2015
10
Leukostasis in Children and Adolescents with Chronic Myeloid Leukemia: Japanese Pediatric Leukemia/Lymphoma Study Group. (26485422)
2015
11
Transfusion medicine illustrated. Catastrophic basilar artery leukostasis in the setting of acute myeloid leukemia. (24724788)
2014
12
Pathologic rupture of the spleen in a patient with acute myelogenous leukemia and leukostasis. (25031169)
2014
13
The effect of puerarin against IL-1I^-mediated leukostasis and apoptosis in retinal capillary endothelial cells (TR-iBRB2). (25593509)
2014
14
Genetic mutations in patients with acute myeloid leukemia and leukostasis. (23548579)
2013
15
Leukostasis in an Adult with AML Presenting as Multiple High Attenuation Brain Masses on CT. (24551717)
2013
16
CD11b+ bone marrow-derived monocytes are the major leukocyte subset responsible for retinal capillary leukostasis in experimental diabetes in mouse and express high levels of CCR5 in the circulation. (22677420)
2012
17
Hyperleukocytosis, leukostasis and leukapheresis: practice management. (22364832)
2012
18
Intra-ophthalmic artery chemotherapy triggers vascular toxicity through endothelial cell inflammation and leukostasis. (22427570)
2012
19
Therapeutic leukapheresis in patients with leukostasis secondary to acute myelogenous leukemia. (21574176)
2011
20
TNFalpha is required for late BRB breakdown in diabetic retinopathy, and its inhibition prevents leukostasis and protects vessels and neurons from apoptosis. (21212173)
2011
21
Reversal of leukostasis-related pulmonary distress syndrome after leukapheresis and low-dose chemotherapy in acute myeloid leukemia. (21825265)
2011
22
Rapid treatment of leukostasis in leukemic mantle cell lymphoma using therapeutic leukapheresis: a case report. (22224069)
2011
23
Pazopanib, a multitargeted tyrosine kinase inhibitor, reduces diabetic retinal vascular leukostasis and leakage. (21945644)
2011
24
Pulmonary leukostasis mimicking tuberculosis in endemic area. (20004472)
2010
25
Phosphomannopentaose sulfate (PI-88) inhibits retinal leukostasis in diabetic rat. (19250642)
2009
26
Targeting leukostasis for the treatment of early diabetic retinopathy. (19619127)
2009
27
Reliability of leukostasis grading score to identify patients with high-risk hyperleukocytosis. (19391131)
2009
28
Inhibition of diabetic leukostasis and blood-retinal barrier breakdown with a soluble form of a receptor for advanced glycation end products. (17251488)
2007
29
Images in clinical medicine. FLT3 Mutation and acute myelogenous leukemia with leukostasis. (17942876)
2007
30
Leukostasis and pigment epithelium-derived factor in rat models of diabetic retinopathy. (17653050)
2007
31
Role of NADPH oxidase and ANG II in diabetes-induced retinal leukostasis. (17652361)
2007
32
TNF-alpha is critical for ischemia-induced leukostasis, but not retinal neovascularization nor VEGF-induced leakage. (17107717)
2007
33
A case report of therapeutic leukapheresis in an adult with chronic myelogenous leukemia presenting with hyperleukocytosis and leukostasis. (17381536)
2007
34
Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood-retinal barrier breakdown in diabetic retinopathy. (17962481)
2007
35
Hyperleukocytosis associated pulmonary leukostasis in acute leukaemia. (16909741)
2006
36
Pigment epithelium-derived factor (PEDF) prevents diabetes- or advanced glycation end products (AGE)-elicited retinal leukostasis. (16797605)
2006
37
Correlation between expression of CD56/NCAM and severe leukostasis in hyperleukocytic acute myelomonocytic leukaemia. (16519701)
2006
38
Role of angiotensin II in retinal leukostasis in the diabetic rat. (16822509)
2006
39
Grading of symptoms in hyperleukocytic leukaemia: a clinical model for the role of different blast types and promyelocytes in the development of leukostasis syndrome. (15876254)
2005
40
Intravitreal injection of corticosteroid attenuates leukostasis and vascular leakage in experimental diabetic retina. (15790913)
2005
41
Case report: mantle cell lymphoma, prolymphocytoid variant, with leukostasis syndrome. (15197401)
2004
42
Management of life-threatening pulmonary leukostasis with single agent imatinib mesylate during CML myeloid blast crisis. (15377482)
2004
43
The role of advanced glycation end products in retinal microvascular leukostasis. (14507893)
2003
44
Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes: role of oxidants and protein kinase-C activation. (12606527)
2003
45
Pulmonary leukostasis and the inhibition of airway neutrophil recruitment are early events in the endotoxemic rat. (11837792)
2002
46
Effective and selective prevention of retinal leukostasis in streptozotocin-induced diabetic rats using gliclazide. (12107755)
2002
47
Leukapheresis in chronic myelomonocytic leukemia with leukostasis syndrome: elevated serum lactate levels as an early sign of microcirculation failure. (12389624)
2002
48
Cerebrovascular nodules in a patient with leukostasis. (12385403)
2002
49
The irreplaceable image: Cerebral leukostasis manifesting as multifocal intracerebral hemorrhage. (11694415)
2001
50
Endothelial cell activation by myeloblasts: molecular mechanisms of leukostasis and leukemic cell dissemination. (11264180)
2001

Variations for Leukostasis

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Expression for genes affiliated with Leukostasis

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Search GEO for disease gene expression data for Leukostasis.

Pathways for genes affiliated with Leukostasis

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Pathways related to Leukostasis according to GeneCards Suite gene sharing:

(show all 29)
idSuper pathwaysScoreTop Affiliating Genes
19.8ICAM1, VCAM1
29.8ICAM1, VCAM1
39.8ICAM1, MPO
49.5NFATC2, NFATC4
5
Show member pathways
9.5NFATC2, NFATC4
69.4KDR, VEGFA
7
Show member pathways
9.4KDR, VEGFA
8
Show member pathways
9.4KDR, VEGFA
99.4KDR, VEGFA
109.4KDR, VEGFA
119.4ICAM1, MPO, VCAM1
129.3ICAM1, SELE, VCAM1
139.3ICAM1, SELE, VCAM1
149.3ICAM1, SELE, VCAM1
159.3ICAM1, SELE, VCAM1
16
Show member pathways
9.2ICAM1, KDR, VCAM1
179.1SELE, SELL
189.1KDR, VCAM1, VEGFA
199.1NFATC2, NFATC4, VEGFA
209.0ICAM1, SELL, VCAM1
218.9ICAM1, SELE, VCAM1, VEGFA
228.8ICAM1, NFATC2, NFATC4, VCAM1
23
Show member pathways
8.8ICAM1, NFATC2, NFATC4, VCAM1
248.8MPO, NFATC2, NFATC4, VCAM1
25
Show member pathways
8.8ICAM1, KDR, VCAM1, VEGFA
26
Show member pathways
8.5KDR, NFATC2, NFATC4, VEGFA
27
Show member pathways
8.5KDR, NFATC2, NFATC4, VEGFA
288.5ICAM1, SELE, SELL, VCAM1
29
Show member pathways
8.3ICAM1, KDR, SELE, VCAM1, VEGFA

GO Terms for genes affiliated with Leukostasis

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Cellular components related to Leukostasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.7ICAM1, SELL, VCAM1
2cell surfaceGO:00099869.3ICAM1, SELL, VCAM1, VEGFA
3extracellular spaceGO:00056159.1ICAM1, MPO, SELE, VCAM1, VEGFA
4membrane raftGO:00451219.0ICAM1, KDR, SELE

Biological processes related to Leukostasis according to GeneCards Suite gene sharing:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1membrane to membrane dockingGO:002261410.5ICAM1, VCAM1
2leukocyte tethering or rollingGO:005090110.3SELE, VCAM1
3calcium-mediated signaling using intracellular calcium sourceGO:003558410.2KDR, VCAM1
4positive regulation of receptor internalizationGO:000209210.2SELE, VEGFA
5negative regulation of endothelial cell apoptotic processGO:200035210.2ICAM1, KDR
6calcineurin-NFAT signaling cascadeGO:003317310.2NFATC2, NFATC4
7cell migration involved in sprouting angiogenesisGO:000204210.2KDR, VEGFA
8positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathwayGO:003803310.1KDR, VEGFA
9positive regulation of endothelial cell migrationGO:001059510.1KDR, VEGFA
10positive regulation of focal adhesion assemblyGO:005189410.1KDR, VEGFA
11positive regulation of positive chemotaxisGO:005092710.1KDR, VEGFA
12heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesGO:000715710.0ICAM1, SELE, VCAM1
13leukocyte cell-cell adhesionGO:000715910.0ICAM1, SELE, VCAM1
14response to hypoxiaGO:000166610.0ICAM1, VCAM1, VEGFA
15extracellular matrix organizationGO:00301989.9ICAM1, KDR, VCAM1
16cellular response to vascular endothelial growth factor stimulusGO:00359249.8KDR, VCAM1, VEGFA
17regulation of cell shapeGO:00083609.8ICAM1, KDR, VEGFA
18regulation of immune responseGO:00507769.6ICAM1, SELL, VCAM1
19leukocyte migrationGO:00509009.5ICAM1, SELE, SELL
20response to lipopolysaccharideGO:00324968.9ICAM1, MPO, SELE, VCAM1

Molecular functions related to Leukostasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:00082019.4MPO, SELL, VEGFA
2integrin bindingGO:00051789.2ICAM1, KDR, VCAM1

Sources for Leukostasis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet