MCID: LKS001
MIFTS: 48

Leukostasis malady

Summaries for Leukostasis

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Leukostasis (aka symptomatic hyperleukocytosis) is a white blood cell count above 100,000/μL. It is... more...

MalaCards: Leukostasis is related to leukemia and acute leukemia. An important gene associated with Leukostasis is SELE (selectin E), and among its related pathways are Cell adhesion molecules (CAMs) and Signaling by VEGF. The compounds pge2 and okt3 have been mentioned in the context of this disorder. Affiliated tissues include lung, brain and myeloid, and related mouse phenotypes are vision/eye and no phenotypic analysis.

Aliases & Classifications for Leukostasis

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT
See all sources

Aliases & Descriptions:

leukostasis 8 10 44 60


External Ids:

Disease Ontology8 DOID:12986
MeSH34 D018921
SNOMED-CT56 30419000
NCIt39 C4062

Related Diseases for Leukostasis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Leukostasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 181)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia30.9ICAM1, TNF, MPO, KDR, SERPINF1, C5AR1
2acute leukemia30.7MPO
3ischemia30.3ICAM1, MPO, VEGFA, KDR, SELE, C5AR1
4diabetic retinopathy30.3ICAM1, AGER, VEGFA, KDR, VCAM1, SERPINF1
5myeloid leukemia30.3MPO
6pneumonia30.0C5AR1, MPO, TNF, ICAM1
7monocytic leukemia29.8VCAM1, TNF
8hypertension29.8ICAM1, VCAM1, SELE
9tuberculosis29.8C5AR1, TNF
10retinal ischemia29.8VEGFA
11retinitis10.5
12acute myeloid leukemia10.1
13hepatitis10.1
14respiratory failure10.1
15central nervous system lymphoma10.1
16cerebritis10.1
17central nervous system leukemia10.1
18mantle cell lymphoma10.1
19childhood leukemia10.1
20acute myocardial infarction10.0SELE
21kawasaki disease10.0SELE
22atopy10.0MPO
23pulmonary fibrosis10.0MPO
24acute pancreatitis10.0MPO
25severe pre-eclampsia10.0VCAM1
26myelodysplastic syndromes10.0MPO
27sjogren's syndrome10.0ICAM1
28pleurisy10.0MPO
29glaucoma10.0SERPINF1
30bronchiectasis10.0MPO
31myocardial infarction10.0AGER
32polycystic ovary syndrome10.0AGER
33essential hypertension10.0AGER
34dementia10.0AGER
35cataract10.0SERPINF1
36chorioamnionitis10.0TNF
37crohn's disease10.0TNF
38schizophrenia10.0AGER
39ankylosing spondylitis10.0TNF
40macular holes10.0SERPINF1
41hypercholesterolemia10.0VCAM1, SELE
42sarcoma10.0KDR
43nephritis10.0MPO, VCAM1
44sickle cell disease10.0SELE, VCAM1
45wegener's granulomatosis10.0SELE, MPO
46familial mediterranean fever10.0TNF
47antiphospholipid syndrome10.0SELE, VCAM1
48rhinitis10.0ICAM1, VCAM1
49hypertriglyceridemia10.0SELE, VCAM1
50dermatomyositis10.0ICAM1, VCAM1

Graphical network of the top 20 diseases related to Leukostasis:



Diseases related to leukostasis

Clinical Features for Leukostasis

About this section

Drugs & Therapeutics for Leukostasis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Leukostasis

Drug clinical trials:

Search ClinicalTrials for Leukostasis

Search NIH Clinical Center for Leukostasis

Search CenterWatch for Leukostasis

Genetic Tests for Leukostasis

About this section

Anatomical Context for Leukostasis

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Leukostasis:

32
Lung, Brain, Myeloid, Endothelial, Monocytes, Bone, Retina

Animal Models for Leukostasis or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Leukostasis:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053919.9SERPINF1, SELE
2MP:00030129.5KDR, AGER
3MP:00107719.4VEGFA, KDR
4MP:00053769.1ICAM1, VCAM1, SELE, C5AR1
5MP:00053858.9SERPINF1, SELE, VCAM1, AGER, MPO
6MP:00053697.5ICAM1, TNF, MPO, AGER, VEGFA, KDR
7MP:00053847.0ICAM1, TNF, AGER, VEGFA, KDR, VCAM1
8MP:00053786.8ICAM1, TNF, AGER, VEGFA, KDR, VCAM1
9MP:00107686.6ICAM1, TNF, MPO, VEGFA, KDR, VCAM1
10MP:00053976.4ICAM1, TNF, MPO, AGER, VEGFA, KDR
11MP:00053876.4ICAM1, TNF, MPO, AGER, VEGFA, KDR

Publications for Leukostasis

About this section
Sources:
50PubMed
See all sources

Articles related to Leukostasis:

(show top 50)    (show all 101)
idTitleAuthorsYear
1
Intra-ophthalmic artery chemotherapy triggers vascular toxicity through endothelial cell inflammation and leukostasis. (22427570)
2012
2
Reversal of leukostasis-related pulmonary distress syndrome after leukapheresis and low-dose chemotherapy in acute myeloid leukemia. (21825265)
2011
3
Pazopanib, a multitargeted tyrosine kinase inhibitor, reduces diabetic retinal vascular leukostasis and leakage. (21945644)
2011
4
Targeting leukostasis for the treatment of early diabetic retinopathy. (19619127)
2009
5
Leukostasis and pigment epithelium-derived factor in rat models of diabetic retinopathy. (17653050)
2007
6
Inhibition of diabetic leukostasis and blood-retinal barrier breakdown with a soluble form of a receptor for advanced glycation end products. (17251488)
2007
7
TNF-alpha is critical for ischemia-induced leukostasis, but not retinal neovascularization nor VEGF-induced leakage. (17107717)
2007
8
A case report of therapeutic leukapheresis in an adult with chronic myelogenous leukemia presenting with hyperleukocytosis and leukostasis. (17381536)
2007
9
Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood-retinal barrier breakdown in diabetic retinopathy. (17962481)
2007
10
Hyperleukocytosis associated pulmonary leukostasis in acute leukaemia. (16909741)
2006
11
Role of angiotensin II in retinal leukostasis in the diabetic rat. (16822509)
2006
12
Pigment epithelium-derived factor (PEDF) prevents diabetes- or advanced glycation end products (AGE)-elicited retinal leukostasis. (16797605)
2006
13
Intravitreal injection of corticosteroid attenuates leukostasis and vascular leakage in experimental diabetic retina. (15790913)
2005
14
Management of life-threatening pulmonary leukostasis with single agent imatinib mesylate during CML myeloid blast crisis. (15377482)
2004
15
The role of advanced glycation end products in retinal microvascular leukostasis. (14507893)
2003
16
Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes: role of oxidants and protein kinase-C activation. (12606527)
2003
17
Effective and selective prevention of retinal leukostasis in streptozotocin-induced diabetic rats using gliclazide. (12107755)
2002
18
Leukapheresis in chronic myelomonocytic leukemia with leukostasis syndrome: elevated serum lactate levels as an early sign of microcirculation failure. (12389624)
2002
19
Cerebrovascular nodules in a patient with leukostasis. (12385403)
2002
20
Endothelial cell activation by myeloblasts: molecular mechanisms of leukostasis and leukemic cell dissemination. (11264180)
2001
21
Integrin-mediated neutrophil adhesion and retinal leukostasis in diabetes. (10752954)
2000
22
Pulmonary leukostasis mimicking pulmonary embolism. (10654454)
2000
23
Hyperleukocytic leukemias and leukostasis: a review of pathophysiology, clinical presentation and management. (10975379)
2000
24
Leukostasis followed by hemorrhage complicating the initiation of chemotherapy in patients with acute myeloid leukemia and hyperleukocytosis: a clinicopathologic report of four cases. (10023704)
1999
25
Endotoxin-induced pulmonary leukostasis in the rat: role of platelet-activating factor and tumor necrosis factor. (8288963)
1994
26
Treatment of acute promyelocytic leukemia with all-trans retinoic acid: successful control of hyperleukocytosis and leukostasis syndrome with leukaphereses and hydroxyurea. (8372818)
1993
27
Increased leukocyte adhesiveness/aggregation and tissue leukostasis following surgical trauma. (8473077)
1993
28
The state of leucocyte adhesiveness/aggregation (LAA) in the peripheral blood of burned mice: an early and sensitive inflammatory indicator and a marker of pulmonary leukostasis. (1793493)
1991
29
An unusual case of hairy cell leukemia: death due to leukostasis and intracerebral hemorrhage. (1748438)
1991
30
Postoperative pulmonary leukostasis. (2403504)
1990
31
Leukostasis: a phenomenon of prolymphocytic leukemia. (2757011)
1989
32
Effects of cardiopulmonary bypass on pulmonary leukostasis and complement activation. (3190431)
1988
33
Interleukin-1-induced granulocytopenia and pulmonary leukostasis in rabbits. (3031000)
1987
34
Quantitative estimation of leukostasis in the posttraumatic lung--canine and human autopsy data. (3615443)
1987
35
Pulmonary leukostasis in a patient with chronic myeloid leukemia. (3475250)
1986
36
Amphotericin B causes aggregation of neutrophils and enhances pulmonary leukostasis. (4037532)
1985
37
Pulmonary leukostasis as the single worst prognostic factor in patients with acute myelocytic leukemia and hyperleukocytosis. (3860006)
1985
38
Lung myeloperoxidase as a measure of pulmonary leukostasis in rabbits. (3001018)
1985
39
Intravascular leukostasis in a horse with myelomonocytic leukemia. (6592873)
1984
40
Hyperleukocytosis and leukostasis: common features of childhood chronic myelogenous leukemia. (6585236)
1984
41
Pulmonary leukostasis in fatal human pneumococcal bacteremia without pneumonia. (6508013)
1984
42
Fatal complement-induced leukostasis after diatrizoate injection. Principles of clinicopathologic diagnosis. (6195360)
1983
43
Gram-positive bacteria-induced granulocytopenia and pulmonary leukostasis in rabbits. (6286493)
1982
44
Reversal of hemodialysis granulocytopenia and pulmonary leukostasis: A clinical manifestation of selective down-regulation of granulocyte responses to C5adesarg. (7229031)
1981
45
Pneumococcus-induced granulocytopenia and pulmonary leukostasis in rabbits. (7452094)
1981
46
Complement-induced vascular leukostasis. Its role in tissue injury. (6893656)
1980
47
Leukostasis in SAczary syndrome. (439311)
1979
48
Reversible respiratory failure due to intravascular leukostasis in chronic myelogenous leukemia. Relationship of oxygen transfer to leukocyte count. (291338)
1979
49
The pathologic characteristics of leukostasis and leukemic nodules occurring in the central nervous system of guinea pigs with L2C/NB leukemia. (1245856)
1976
50
Fatal pulmonary leukostasis following treatment in acute myelogenous leukemia. (4507847)
1972

Genetic Variations for Leukostasis

About this section

Expression for genes affiliated with Leukostasis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Leukostasis

Search GEO for disease gene expression data for Leukostasis.

Pathways for genes affiliated with Leukostasis

About this section
Sources:
29KEGG, 53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 51QIAGEN
See all sources

Compounds for genes affiliated with Leukostasis

About this section
Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 24HMDB, 2BitterDB
See all sources

Compounds related to Leukostasis according to GeneCards/GeneDecks:

(show top 50)    (show all 138)
idCompoundScoreTop Affiliating Genes
1pge24410.3VEGFA
2okt34410.2ICAM1, VCAM1
3triamcinolone acetonide44 2811.2SERPINF1
4matrigel4410.1SELE, KDR
5ulinastatin4410.0MPO, ICAM1
6diphenyleneiodonium449.8SERPINF1, VCAM1, MPO
78 methoxypsoralen449.7SELE, VCAM1, ICAM1
8sele449.7ICAM1, VCAM1, SELE
9prednisolone44 28 1111.7MPO, C5AR1
10troglitazone44 28 59 1112.5SELE, ICAM1, VCAM1
11ro 31-7549449.4TNF, VCAM1, SELE
12cobalt chloride449.4VEGFA, SELE, VCAM1
13hcec449.4KDR, ICAM1, VCAM1
14celastrol44 5910.4SELE, VCAM1, TNF
15slex449.2VCAM1, ICAM1, SELE
16dexamethasone44 49 28 1112.1VEGFA, SERPINF1, KDR
17fluticasone propionate44 49 59 1112.1TNF, MPO, VCAM1, SELE
18polymyxin b449.1SELE, VCAM1, TNF, ICAM1
19groalpha449.1VCAM1, TNF, ICAM1, SELE
20rantes449.1C5AR1, ICAM1, TNF
21sulfasalazine44 28 49 1112.0ICAM1, TNF, MPO, SELE
22budesonide44 49 1111.0VCAM1, MPO, ICAM1, TNF
23fenofibrate44 49 1111.0TNF, ICAM1, VCAM1, SELE
24fluorescein44 1110.0MPO, C5AR1, SERPINF1, VEGFA
25gliclazide44 49 1111.0SELE, VEGFA, MPO, ICAM1, VCAM1
26pdtc449.0VCAM1, TNF, ICAM1, SELE
27pentoxifylline44 119.9ICAM1, MPO, TNF, VCAM1
288-isoprostane448.7SELE, ICAM1, VCAM1, MPO, TNF
29n-formylmethionyl-leucylphenylalanine448.7C5AR1, MPO, ICAM1, TNF
30herbimycin a44 599.7VCAM1, TNF, ICAM1, SELE
31endotoxin448.5ICAM1, C5AR1, SELE, VCAM1, TNF
32atorvastatin44 49 28 11 2412.5TNF, SELE, VEGFA, VCAM1, ICAM1
33fmlp448.5VCAM1, ICAM1, TNF, C5AR1, MPO
34fibrinogen448.4TNF, ICAM1, SELE, C5AR1, VCAM1
35oxygen44 249.3ICAM1, TNF, MPO, SERPINF1, C5AR1
36histamine44 28 2410.2TNF, MPO, VCAM1, SELE, C5AR1, ICAM1
37lactate448.1VCAM1, SELE, ICAM1, TNF, MPO, KDR
38apocynin44 599.1ICAM1, TNF, MPO, VEGFA, VCAM1, SELE
39mg 13244 599.0TNF, ICAM1, VEGFA, KDR
40serine448.0AGER, TNF, C5AR1, SERPINF1, SELE, MPO
41simvastatin44 49 59 28 11 2412.9SELE, ICAM1, TNF, VEGFA, KDR, VCAM1
42sb 20358044 598.9VCAM1, VEGFA, C5AR1, TNF, ICAM1, SELE
43heparin44 28 11 2410.9AGER, C5AR1, VCAM1, SELE, VEGFA, MPO
44ly294002447.9SELE, VCAM1, KDR, VEGFA, TNF, ICAM1
45genistein44 28 59 2 11 2412.9ICAM1, TNF, SELE, VEGFA, KDR, VCAM1
46h2o2447.8TNF, SERPINF1, C5AR1, KDR, MPO, ICAM1
47prostacyclin447.0VCAM1, SELE, C5AR1, KDR, VEGFA, TNF
48nitric oxide44 11 248.8C5AR1, ICAM1, TNF, MPO, AGER, KDR
49n acetylcysteine446.8TNF, VCAM1, SELE, SERPINF1, VEGFA, AGER
50vegf446.2AGER, VCAM1, C5AR1, SELE, SERPINF1, KDR

GO Terms for genes affiliated with Leukostasis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Leukostasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membrane raftGO:0451218.7TNF, KDR, SELE
2external side of plasma membraneGO:0098978.5ICAM1, TNF, KDR, VCAM1
3cell surfaceGO:0099868.2C5AR1, VCAM1, VEGFA, TNF
4integral to plasma membraneGO:0058877.5C5AR1, KDR, AGER, TNF, ICAM1
5extracellular spaceGO:0056157.4SERPINF1, SELE, VCAM1, VEGFA, MPO, TNF
6plasma membraneGO:0058867.2TNF, AGER, KDR, VCAM1, SELE, C5AR1

Biological processes related to Leukostasis according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1membrane to membrane dockingGO:02261410.1VCAM1, ICAM1
2positive regulation of leukocyte migrationGO:0026879.8SELE, VEGFA
3leukocyte cell-cell adhesionGO:0071599.8SELE, VCAM1, ICAM1
4heterophilic cell-cell adhesionGO:0071579.8ICAM1, VCAM1, SELE
5positive regulation of receptor internalizationGO:0020929.7VEGFA, SELE
6surfactant homeostasisGO:0431299.6KDR, VEGFA
7positive regulation of positive chemotaxisGO:0509279.6KDR, VEGFA
8positive regulation of focal adhesion assemblyGO:0518949.6VEGFA, KDR
9induction of positive chemotaxisGO:0509309.6VEGFA, AGER
10cell migration involved in sprouting angiogenesisGO:0020429.6KDR, VEGFA
11negative regulation of growth of symbiont in hostGO:0441309.5MPO, TNF
12cellular response to glucose stimulusGO:0713339.5VCAM1, ICAM1
13leukocyte tethering or rollingGO:0509019.4SELE, VCAM1, TNF
14cellular response to vascular endothelial growth factor stimulusGO:0359249.4KDR, VEGFA
15vascular endothelial growth factor receptor signaling pathwayGO:0480109.3VEGFA, KDR
16ovarian follicle developmentGO:0015419.3KDR, VEGFA, ICAM1
17positive regulation of nitric oxide biosynthetic processGO:0454299.3TNF, ICAM1
18positive regulation of protein complex assemblyGO:0313349.3TNF, VEGFA
19regulation of cell shapeGO:0083609.2ICAM1, VEGFA, KDR
20branching morphogenesis of an epithelial tubeGO:0487549.2KDR, VEGFA
21positive regulation of NF-kappaB transcription factor activityGO:0510929.1AGER, TNF, ICAM1
22positive regulation of ERK1 and ERK2 cascadeGO:0703748.9TNF, KDR, C5AR1
23positive regulation of protein phosphorylationGO:0019348.8KDR, VEGFA, TNF
24response to hypoxiaGO:0016668.8VCAM1, VEGFA, TNF
25inflammatory responseGO:0069548.7TNF, AGER, SELE, C5AR1

Molecular functions related to Leukostasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:0048889.3SELE, AGER, ICAM1
2integrin bindingGO:0051789.0VCAM1, KDR, ICAM1

Products for genes affiliated with Leukostasis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Leukostasis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet