Aliases & Classifications for Leukostasis

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Aliases & Descriptions for Leukostasis:

Name: Leukostasis 10 47 12 36 65

Classifications:



External Ids:

Disease Ontology10 DOID:12986
MeSH36 D018921
SNOMED-CT59 30419000
NCIt42 C4062
UMLS65 C0282548

Summaries for Leukostasis

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Wikipedia:68 Leukostasis (aka symptomatic hyperleukocytosis) is a white blood cell count above 100,000/╬╝L. It is... more...

MalaCards based summary: Leukostasis is related to thrombocytopenia and leukemia, and has symptoms including breakthrough pain, psychomotor skills impaired and metastatic pain. An important gene associated with Leukostasis is ICAM1 (Intercellular Adhesion Molecule 1), and among its related pathways are Immune response_MIF-mediated glucocorticoid regulation and LDL Oxidation in Atherogenesis. Affiliated tissues include brain, lung and myeloid, and related mouse phenotypes are muscle and vision/eye.

Related Diseases for Leukostasis

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Diseases related to Leukostasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 98)
idRelated DiseaseScoreTop Affiliating Genes
1thrombocytopenia29.5ICAM1, SELE, VCAM1
2leukemia10.5
3plasma cell neoplasm10.5ICAM1, VCAM1
4liver cirrhosis10.5ICAM1, VCAM1
5monckeberg arteriosclerosis10.4ICAM1, VCAM1
6exudative glomerulonephritis10.4ICAM1, MPO
7meconium aspiration syndrome10.4ICAM1, MPO
8angioedema10.4ICAM1, MPO
9crescentic glomerulonephritis10.4ICAM1, MPO
10colon carcinoma in situ10.3ICAM1, SELE
11retinitis10.3
12oral pharyngeal disorders10.3ICAM1, VCAM1
13solar retinopathy10.3ICAM1, SELE
14timothy grass allergy10.3ICAM1, MPO
15diphyllobothriasis10.3ICAM1, SELE
16dengue hemorrhagic fever10.3ICAM1, VCAM1
17intra-abdominal lymph node mast cell malignancy10.2ICAM1, SELE
18scarlet fever10.2ITGAM, MPO
19autosomal dominant cerebellar ataxia10.2ICAM1, SELE
20myeloid leukemia10.2
21polyneuropathy mental retardation acromicria premature menopause10.2ICAM1, VCAM1
22tuberculoid leprosy10.2ICAM1, MPO
23gestational diabetes10.2AGER, SELE
24granulocytopenia10.1
25lymphoma10.1
26ischemia10.1
27bladder urachal squamous cell carcinoma10.1KDR, VEGFA
28suprasellar meningioma10.1SERPINF1, VEGFA
29villonodular synovitis10.0ITGAM, MPO
30endotheliitis10.0
31meningocele10.0KDR, VEGFA
32dyskeratosis congenita10.0KDR, VEGFA
33protein s deficiency10.0SERPINF1, VEGFA
34gastric neuroendocrine neoplasm10.0KDR, VEGFA
35qualitative platelet defect10.0ICAM1, MPO, VCAM1
36suppurative uveitis10.0ICAM1, MPO, VCAM1
37inherited metabolic disorder10.0KDR, VEGFA
38hepatitis10.0
39respiratory failure10.0
40pseudohypoaldosteronism, type iid10.0ICAM1, MPO, VCAM1
41immature cataract9.9KDR, VEGFA
42cryptogenic organizing pneumonia9.9MPO, VEGFA
43rhizomelic dysplasia patterson lowry type9.9ICAM1, SELE, VCAM1
44inferior myocardial infarction9.9ICAM1, SELE, VCAM1
45large intestine lipoma9.9VCAM1, VEGFA
46hypospadias-hypertelorism-coloboma and deafness syndrome9.9KDR, VEGFA
47food allergy9.9ICAM1, SELE
48hypothyroidism due to deficient transcription factors involved in pituitary development or function9.9KDR, VEGFA
49malignant giant cell tumor of the tendon sheath9.9ICAM1, SELE, VCAM1
50acute leukemia9.9

Graphical network of the top 20 diseases related to Leukostasis:



Diseases related to leukostasis

Symptoms for Leukostasis

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UMLS symptoms related to Leukostasis:


breakthrough pain, psychomotor skills impaired, metastatic pain, tumor pain, cancer pain, cachexia

Drugs & Therapeutics for Leukostasis

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Leukostasis


Cochrane evidence based reviews: leukostasis

Genetic Tests for Leukostasis

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Anatomical Context for Leukostasis

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MalaCards organs/tissues related to Leukostasis:

33
Brain, Lung, Myeloid, Thyroid, Colon, Liver, Endothelial

Animal Models for Leukostasis or affiliated genes

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MGI Mouse Phenotypes related to Leukostasis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.2AGER, ICAM1, KDR, MPO, VEGFA
2MP:00053918.1ICAM1, KDR, SELE, SERPINF1, VEGFA
3MP:00053847.4AGER, ICAM1, ITGAM, KDR, SELE, VCAM1
4MP:00053766.8AGER, ICAM1, ITGAM, KDR, MPO, SELE
5MP:00053976.7AGER, ICAM1, ITGAM, KDR, MPO, SELE
6MP:00053856.5AGER, ICAM1, KDR, MPO, SELE, SERPINF1
7MP:00053876.4AGER, ICAM1, ITGAM, KDR, MPO, SELE

Publications for Leukostasis

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Articles related to Leukostasis:

(show top 50)    (show all 112)
idTitleAuthorsYear
1
Leukostasis in adult acute hyperleukocytic leukemia: a clinician's digest. (27018197)
2016
2
Leukostasis Retinopathy: A New Clinical Manifestation of Chronic Myeloid Leukemia With Severe Hyperleukocytosis. (26247460)
2015
3
NFAT isoforms play distinct roles in TNFI+-induced retinal leukostasis. (26527057)
2015
4
Leukostasis in Children and Adolescents with Chronic Myeloid Leukemia: Japanese Pediatric Leukemia/Lymphoma Study Group. (26485422)
2015
5
Pathologic rupture of the spleen in a patient with acute myelogenous leukemia and leukostasis. (25031169)
2014
6
Transfusion medicine illustrated. Catastrophic basilar artery leukostasis in the setting of acute myeloid leukemia. (24724788)
2014
7
Genetic mutations in patients with acute myeloid leukemia and leukostasis. (23548579)
2013
8
Leukostasis in an Adult with AML Presenting as Multiple High Attenuation Brain Masses on CT. (24551717)
2013
9
CD11b+ bone marrow-derived monocytes are the major leukocyte subset responsible for retinal capillary leukostasis in experimental diabetes in mouse and express high levels of CCR5 in the circulation. (22677420)
2012
10
Hyperleukocytosis, leukostasis and leukapheresis: practice management. (22364832)
2012
11
Reversal of leukostasis-related pulmonary distress syndrome after leukapheresis and low-dose chemotherapy in acute myeloid leukemia. (21825265)
2011
12
Rapid treatment of leukostasis in leukemic mantle cell lymphoma using therapeutic leukapheresis: a case report. (22224069)
2011
13
Phosphomannopentaose sulfate (PI-88) inhibits retinal leukostasis in diabetic rat. (19250642)
2009
14
Targeting leukostasis for the treatment of early diabetic retinopathy. (19619127)
2009
15
Reliability of leukostasis grading score to identify patients with high-risk hyperleukocytosis. (19391131)
2009
16
Leukostasis and pigment epithelium-derived factor in rat models of diabetic retinopathy. (17653050)
2007
17
Role of NADPH oxidase and ANG II in diabetes-induced retinal leukostasis. (17652361)
2007
18
Correlation between expression of CD56/NCAM and severe leukostasis in hyperleukocytic acute myelomonocytic leukaemia. (16519701)
2006
19
Intravitreal injection of corticosteroid attenuates leukostasis and vascular leakage in experimental diabetic retina. (15790913)
2005
20
Case report: mantle cell lymphoma, prolymphocytoid variant, with leukostasis syndrome. (15197401)
2004
21
Management of life-threatening pulmonary leukostasis with single agent imatinib mesylate during CML myeloid blast crisis. (15377482)
2004
22
The role of advanced glycation end products in retinal microvascular leukostasis. (14507893)
2003
23
Pulmonary leukostasis and the inhibition of airway neutrophil recruitment are early events in the endotoxemic rat. (11837792)
2002
24
Effective and selective prevention of retinal leukostasis in streptozotocin-induced diabetic rats using gliclazide. (12107755)
2002
25
Leukapheresis in chronic myelomonocytic leukemia with leukostasis syndrome: elevated serum lactate levels as an early sign of microcirculation failure. (12389624)
2002
26
Integrin-mediated neutrophil adhesion and retinal leukostasis in diabetes. (10752954)
2000
27
Pulmonary leukostasis mimicking pulmonary embolism. (10654454)
2000
28
Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition. (10485912)
1999
29
Use of genetically manipulated strains of Clostridium perfringens reveals that both alpha-toxin and theta-toxin are required for vascular leukostasis to occur in experimental gas gangrene. (10456947)
1999
30
Pressure-related capillary leukostasis following ischemia-reperfusion and hemorrhagic shock. (8342655)
1993
31
Involvement of the complement system in the pathogenesis of pulmonary leukostasis in experimental myelocytic leukemia. (8412322)
1993
32
Acute leukostasis pulmonary distress syndrome. (1402733)
1992
33
Pulmonary leukostasis secondary to all-trans retinoic acid in the treatment of acute promyelocytic leukemia in first relapse. (1602800)
1992
34
Pulmonary leukostasis without hyperleukocytosis: a clinicopathologic study of 16 cases. (1566743)
1992
35
Development of pulmonary leukostasis in experimental myelocytic leukemia in the Brown-Norway rat. (1552745)
1992
36
Effects of cardiopulmonary bypass on pulmonary leukostasis and complement activation. (3190431)
1988
37
Interleukin-1-induced granulocytopenia and pulmonary leukostasis in rabbits. (3031000)
1987
38
Quantitative estimation of leukostasis in the posttraumatic lung--canine and human autopsy data. (3615443)
1987
39
Pulmonary leukostasis in a patient with chronic myeloid leukemia. (3475250)
1986
40
Aleukaemic leukostasis in a case of large cell non-Hodgkin's lymphoma: report of a case with a distinctive central nervous system involvement. (3760899)
1986
41
Streptococcus pneumoniae-induced alterations in levels of circulating thromboxane and prostacyclin: dissociation from granulocytopenia, thrombocytopenia, and pulmonary leukostasis. (3510262)
1986
42
Intravascular leukostasis in a horse with myelomonocytic leukemia. (6592873)
1984
43
Reversal of hemodialysis granulocytopenia and pulmonary leukostasis: A clinical manifestation of selective down-regulation of granulocyte responses to C5adesarg. (7229031)
1981
44
Pneumococcus-induced granulocytopenia and pulmonary leukostasis in rabbits. (7452094)
1981
45
Complement-induced vascular leukostasis. Its role in tissue injury. (6893656)
1980
46
Pulmonary leukostasis and its relationship to pulmonary dysfunction in sheep and rabbits. (7351034)
1980
47
Leukostasis in SAczary syndrome. (439311)
1979
48
Rapid cytoreduction in acute leukemia. Management of cerebral leukostasis by cell pheresis. (272799)
1978
49
Hydroxyurea in the prevention of the effects of leukostasis in acute leukemia. (268956)
1977
50
Hemodialysis leukopenia. Pulmonary vascular leukostasis resulting from complement activation by dialyzer cellophane membranes. (856872)
1977

Variations for Leukostasis

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Expression for genes affiliated with Leukostasis

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Search GEO for disease gene expression data for Leukostasis.

Pathways for genes affiliated with Leukostasis

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Pathways related to Leukostasis according to GeneCards Suite gene sharing:

(show all 24)
idSuper pathwaysScoreTop Affiliating Genes
19.8ICAM1, VCAM1
29.4ICAM1, MPO, VCAM1
39.3ICAM1, SELE, VCAM1
49.3ICAM1, SELE, VCAM1
59.3ICAM1, SELE, VCAM1
69.3ICAM1, SELE, VCAM1
79.3ICAM1, ITGAM, VCAM1
8
Show member pathways
9.2KDR, VEGFA
99.2KDR, VEGFA
109.2KDR, VEGFA
119.2KDR, VEGFA
129.2KDR, VEGFA
139.2KDR, VEGFA
14
Show member pathways
9.1ITGAM, SELE, VCAM1
15
Show member pathways
8.9KDR, VCAM1, VEGFA
168.9KDR, VCAM1, VEGFA
17
Show member pathways
8.9ICAM1, ITGAM, KDR, VCAM1
18
Show member pathways
8.9ICAM1, ITGAM, KDR, VCAM1
198.8AGER, ICAM1, ITGAM, MPO
208.8ICAM1, ITGAM, SELE, VCAM1
218.1AGER, ICAM1, SELE, VCAM1, VEGFA
22
Show member pathways
8.1ICAM1, KDR, SELE, VCAM1, VEGFA
23
Show member pathways
8.1ICAM1, ITGAM, KDR, VCAM1, VEGFA
24
Show member pathways
8.1ICAM1, ITGAM, KDR, VCAM1, VEGFA

GO Terms for genes affiliated with Leukostasis

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Biological processes related to Leukostasis according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1leukocyte cell-cell adhesionGO:000715910.4ICAM1, VCAM1
2calcium-mediated signaling using intracellular calcium sourceGO:003558410.2KDR, VCAM1
3negative regulation of endothelial cell apoptotic processGO:200035210.1ICAM1, KDR
4interferon-gamma-mediated signaling pathwayGO:006033310.1ICAM1, VCAM1
5heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesGO:000715710.1ICAM1, SELE
6cell migration involved in sprouting angiogenesisGO:00020429.8KDR, VEGFA
7positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathwayGO:00380339.8KDR, VEGFA
8ovarian follicle developmentGO:00015419.7ICAM1, VEGFA
9vasculogenesisGO:00015709.5KDR, VEGFA
10positive regulation of receptor internalizationGO:00020929.5SELE, VEGFA
11negative regulation of endothelial cell migrationGO:00105969.4AGER, SERPINF1
12cellular response to glucose stimulusGO:00713339.4AGER, ICAM1, SERPINF1
13cell adhesionGO:00071559.0ICAM1, SELE, VCAM1
14extracellular matrix organizationGO:00301988.9ICAM1, ITGAM, KDR, VCAM1

Sources for Leukostasis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet