Aliases & Classifications for Leukostasis

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Aliases & Descriptions for Leukostasis:

Name: Leukostasis 11 13 48 37 66

Classifications:



External Ids:

Disease Ontology11 DOID:12986
MeSH37 D018921
SNOMED-CT60 30419000
NCIt43 C4062

Summaries for Leukostasis

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Wikipedia:69 Leukostasis (aka symptomatic hyperleukocytosis) is a white blood cell count above 100,000/╬╝L. It is... more...

MalaCards based summary: Leukostasis is related to leukemia and hypertrophy of tongue papillae, and has symptoms including cachexia, cancer pain and tumor pain. An important gene associated with Leukostasis is ICAM1 (Intercellular Adhesion Molecule 1), and among its related pathways are Immune response_MIF-mediated glucocorticoid regulation and African trypanosomiasis. Affiliated tissues include lung, brain and myeloid, and related mouse phenotypes are muscle and cellular.

Related Diseases for Leukostasis

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Diseases related to Leukostasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 106)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia10.5
2hypertrophy of tongue papillae10.5SERPINF1, VEGFA
3bladder urachal carcinoma10.5KDR, VEGFA
4silicosiderosis10.5KDR, VEGFA
5overnutrition10.4ICAM1, VCAM1
6malignant gastric germ cell tumor10.4KDR, VEGFA
7arthrogryposis, ectodermal dysplasia, cleft lip/palate, and developmental delay10.4KDR, VEGFA
8marginal corneal ulcer10.4ICAM1, VCAM1
9epidermolysis bullosa10.4KDR, VEGFA
10hereditary renal cell carcinoma10.4ICAM1, VEGFA
11iliac vein thrombophlebitis10.4KDR, VEGFA
12rhizomelic pseudopolyarthritis10.4ICAM1, VCAM1
13intraneural perineurioma10.4ICAM1, VEGFA
14acute bilateral depigmentation of the iris10.4KDR, VEGFA
15thrombophilia10.4SERPINF1, VEGFA
16developmental coordination disorder10.4ICAM1, VEGFA
17posterolateral myocardial infarction10.4ICAM1, VCAM1
18facial nerve disease10.4SERPINF1, VEGFA
19spastic paraplegia-paget disease of bone syndrome10.4ICAM1, VCAM1
20west nile fever10.4ICAM1, VCAM1
21ocular melanoma10.4KDR, VEGFA
22scn8a encephalopathy10.3SERPINF1, VEGFA
23arteriolosclerosis10.3ICAM1, VCAM1
24gastric small cell carcinoma10.3KDR, VEGFA
25marchiafava bignami disease10.3AGER, VEGFA
26retinitis10.3
27perivascular epithelioid cell tumor10.3KDR, VEGFA
28liver disease10.3ICAM1, VCAM1
29lens disease10.3KDR, VEGFA
30chromoblastomycosis10.3ICAM1, MPO
31hyperinsulinism10.2KDR, VEGFA
32dentin dysplasia10.2ICAM1, VCAM1
33dementia - subcortical10.2ICAM1, VCAM1
34lipoatrophy with diabetes, leukomelanodermic papules, liver steatosis, and hypertrophic cardiomyopathy10.2KDR, VEGFA
35speech disorder10.2ICAM1, SERPINF1, VEGFA
36desquamative interstitial pneumonia10.2MPO, VEGFA
37chikungunya10.2KDR, VEGFA
38myeloid leukemia10.2
39calcaneonavicular coalition10.2KDR, SERPINF1, VEGFA
40epidural abscess10.2KDR, SERPINF1, VEGFA
41albinism, oculocutaneous, type ia10.2KDR, SERPINF1, VEGFA
42opportunistic mycosis10.1ICAM1, KDR, VEGFA
43acute porphyria10.1KDR, MPO
44third cranial nerve disease10.1KDR, SERPINF1, VEGFA
45upper gum cancer10.1ITGAM, MPO
46shwartzman phenomenon10.1ICAM1, SELL
47apocrine adenoma10.1KDR, VEGFA
48granulocytopenia10.1
49intracranial hemorrhage in brain cerebrovascular malformations10.1ICAM1, KDR, VEGFA
50lymphoma10.1

Graphical network of the top 20 diseases related to Leukostasis:



Diseases related to leukostasis

Symptoms for Leukostasis

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UMLS symptoms related to Leukostasis:


cachexia, cancer pain, tumor pain, metastatic pain, psychomotor skills impaired, breakthrough pain

Drugs & Therapeutics for Leukostasis

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Leukostasis


Cochrane evidence based reviews: leukostasis

Genetic Tests for Leukostasis

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Anatomical Context for Leukostasis

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MalaCards organs/tissues related to Leukostasis:

34
Lung, Brain, Myeloid, Endothelial, Neutrophil, Monocytes, Bone

Animal Models for Leukostasis or affiliated genes

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MGI Mouse Phenotypes related to Leukostasis:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.3AGER, ICAM1, KDR, MPO, VEGFA
2MP:00053847.3AGER, ICAM1, ITGAM, KDR, SELL, VCAM1
3MP:00053766.7AGER, ICAM1, ITGAM, KDR, MPO, SELL
4MP:00053876.4AGER, ICAM1, ITGAM, KDR, MPO, SELL
5MP:00053856.3AGER, ICAM1, KDR, MPO, SELL, SERPINF1
6MP:00053976.2AGER, ICAM1, ITGAM, KDR, MPO, SELL

Publications for Leukostasis

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Articles related to Leukostasis:

(show top 50)    (show all 112)
idTitleAuthorsYear
1
Exchange Transfusion and Leukapheresis in Pediatric Patients with AML With High Risk of Early Death by Bleeding and Leukostasis. (26670831)
2016
2
Leukostasis Retinopathy: A New Clinical Manifestation of Chronic Myeloid Leukemia With Severe Hyperleukocytosis. (26247460)
2015
3
How we approach a patient with symptoms of leukostasis requiring emergent leukocytapheresis. (26267387)
2015
4
Pulmonary leukostasis with severe respiratory impairment as a debut of acute myeloid leukemia. (26157660)
2015
5
Transfusion medicine illustrated. Catastrophic basilar artery leukostasis in the setting of acute myeloid leukemia. (24724788)
2014
6
Genetic mutations in patients with acute myeloid leukemia and leukostasis. (23548579)
2013
7
Leukostasis in an Adult with AML Presenting as Multiple High Attenuation Brain Masses on CT. (24551717)
2013
8
Therapeutic leukapheresis in patients with leukostasis secondary to acute myelogenous leukemia. (21574176)
2011
9
Phosphomannopentaose sulfate (PI-88) inhibits retinal leukostasis in diabetic rat. (19250642)
2009
10
Inhibition of diabetic leukostasis and blood-retinal barrier breakdown with a soluble form of a receptor for advanced glycation end products. (17251488)
2007
11
Images in clinical medicine. FLT3 Mutation and acute myelogenous leukemia with leukostasis. (17942876)
2007
12
Hyperleukocytosis associated pulmonary leukostasis in acute leukaemia. (16909741)
2006
13
The role of advanced glycation end products in retinal microvascular leukostasis. (14507893)
2003
14
Pulmonary leukostasis and the inhibition of airway neutrophil recruitment are early events in the endotoxemic rat. (11837792)
2002
15
Effective and selective prevention of retinal leukostasis in streptozotocin-induced diabetic rats using gliclazide. (12107755)
2002
16
Leukapheresis in chronic myelomonocytic leukemia with leukostasis syndrome: elevated serum lactate levels as an early sign of microcirculation failure. (12389624)
2002
17
Cerebrovascular nodules in a patient with leukostasis. (12385403)
2002
18
The irreplaceable image: Cerebral leukostasis manifesting as multifocal intracerebral hemorrhage. (11694415)
2001
19
Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition. (10485912)
1999
20
T-lymphocytes contribute to hepatic leukostasis and hypoxic stress induced by gut ischemia-reperfusion. (10654278)
1999
21
Leukostasis followed by hemorrhage complicating the initiation of chemotherapy in patients with acute myeloid leukemia and hyperleukocytosis: a clinicopathologic report of four cases. (10023704)
1999
22
Transgenic mice with increased copper/zinc-superoxide dismutase activity are resistant to hepatic leukostasis and capillary no-reflow after gut ischemia/reperfusion. (9758638)
1998
23
Central nervous system leukostasis in patients with leukemias and lymphomas. (8673423)
1995
24
Endotoxin-induced pulmonary leukostasis in the rat: role of platelet-activating factor and tumor necrosis factor. (8288963)
1994
25
Pressure-related capillary leukostasis following ischemia-reperfusion and hemorrhagic shock. (8342655)
1993
26
Involvement of the complement system in the pathogenesis of pulmonary leukostasis in experimental myelocytic leukemia. (8412322)
1993
27
Acute leukostasis pulmonary distress syndrome. (1402733)
1992
28
Development of pulmonary leukostasis in experimental myelocytic leukemia in the Brown-Norway rat. (1552745)
1992
29
The state of leucocyte adhesiveness/aggregation (LAA) in the peripheral blood of burned mice: an early and sensitive inflammatory indicator and a marker of pulmonary leukostasis. (1793493)
1991
30
An unusual case of hairy cell leukemia: death due to leukostasis and intracerebral hemorrhage. (1748438)
1991
31
Experimental myelocytic leukemia in the Brown-Norway rat as a model for pulmonary leukostasis. (2000946)
1991
32
Effects of cardiopulmonary bypass on pulmonary leukostasis and complement activation. (3190431)
1988
33
Interleukin-1-induced granulocytopenia and pulmonary leukostasis in rabbits. (3031000)
1987
34
High-voltage irradiation and hydroxyurea for pulmonary leukostasis in acute myelomonocytic leukemia. (3113160)
1987
35
Pulmonary leukostasis in a patient with chronic myeloid leukemia. (3475250)
1986
36
Streptococcus pneumoniae-induced alterations in levels of circulating thromboxane and prostacyclin: dissociation from granulocytopenia, thrombocytopenia, and pulmonary leukostasis. (3510262)
1986
37
Amphotericin B causes aggregation of neutrophils and enhances pulmonary leukostasis. (4037532)
1985
38
Distribution of pneumococcus-induced augmentation of tissue leukostasis in rabbits: specificity for the pulmonary vascular bed. (3973472)
1985
39
Pneumococcal sonicate-induced biphasic granulocytopenia and its dissociation from pulmonary leukostasis. The contribution of pneumococcal products and complement to early and late granulocytopenic phases. (6644159)
1983
40
Fatal complement-induced leukostasis after diatrizoate injection. Principles of clinicopathologic diagnosis. (6195360)
1983
41
Respiratory failure due to pulmonary leukostasis following chemotherapy of acute nonlymphocytic leukemia. (6831346)
1983
42
Gram-positive bacteria-induced granulocytopenia and pulmonary leukostasis in rabbits. (6286493)
1982
43
Reversal of hemodialysis granulocytopenia and pulmonary leukostasis: A clinical manifestation of selective down-regulation of granulocyte responses to C5adesarg. (7229031)
1981
44
Complement-induced vascular leukostasis. Its role in tissue injury. (6893656)
1980
45
Pulmonary leukostasis and its relationship to pulmonary dysfunction in sheep and rabbits. (7351034)
1980
46
Reversible respiratory failure due to intravascular leukostasis in chronic myelogenous leukemia. Relationship of oxygen transfer to leukocyte count. (291338)
1979
47
Rapid cytoreduction in acute leukemia. Management of cerebral leukostasis by cell pheresis. (272799)
1978
48
Leukostasis associated with blood transfusion in acute myeloid leukaemia. (273461)
1978
49
Hydroxyurea in the prevention of the effects of leukostasis in acute leukemia. (268956)
1977
50
Hemodialysis leukopenia. Pulmonary vascular leukostasis resulting from complement activation by dialyzer cellophane membranes. (856872)
1977

Variations for Leukostasis

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Expression for genes affiliated with Leukostasis

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Search GEO for disease gene expression data for Leukostasis.

Pathways for genes affiliated with Leukostasis

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Pathways related to Leukostasis according to GeneCards Suite gene sharing:

(show all 23)
idSuper pathwaysScoreTop Affiliating Genes
19.8ICAM1, VCAM1
29.8ICAM1, VCAM1
39.8ICAM1, VCAM1
49.8ICAM1, VCAM1
59.7KDR, VEGFA
69.7KDR, VEGFA
79.7KDR, VEGFA
8
Show member pathways
9.7KDR, VEGFA
99.7KDR, VEGFA
10
Show member pathways
9.7KDR, VEGFA
119.4ICAM1, MPO, VCAM1
129.3KDR, VCAM1, VEGFA
139.3ICAM1, SELL, VCAM1
149.3ICAM1, ITGAM, VCAM1
159.0ITGAM, MPO, SELL
16
Show member pathways
9.0ICAM1, KDR, VCAM1, VEGFA
17
Show member pathways
8.8ICAM1, ITGAM, KDR, VCAM1
18
Show member pathways
8.8ICAM1, ITGAM, KDR, VCAM1
198.7ICAM1, ITGAM, SELL, VCAM1
208.6AGER, ICAM1, VCAM1, VEGFA
21
Show member pathways
8.5ICAM1, ITGAM, KDR, VCAM1, VEGFA
22
Show member pathways
8.5ICAM1, ITGAM, KDR, VCAM1, VEGFA
238.4AGER, ICAM1, ITGAM, MPO

GO Terms for genes affiliated with Leukostasis

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Cellular components related to Leukostasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.5ICAM1, SELL, VCAM1
2cell surfaceGO:00099867.3AGER, ICAM1, ITGAM, SELL, VCAM1, VEGFA
3extracellular spaceGO:00056157.1AGER, ICAM1, ITGAM, MPO, SERPINF1, VCAM1

Biological processes related to Leukostasis according to GeneCards Suite gene sharing:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1membrane to membrane dockingGO:002261410.4ICAM1, VCAM1
2leukocyte cell-cell adhesionGO:000715910.4ICAM1, VCAM1
3negative regulation of endothelial cell apoptotic processGO:200035210.3ICAM1, KDR
4positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathwayGO:003803310.3KDR, VEGFA
5cell migration involved in sprouting angiogenesisGO:000204210.3KDR, VEGFA
6positive regulation of endothelial cell migrationGO:001059510.3KDR, VEGFA
7positive regulation of positive chemotaxisGO:005092710.3KDR, VEGFA
8heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesGO:000715710.2ICAM1, VCAM1
9positive regulation of focal adhesion assemblyGO:005189410.2KDR, VEGFA
10ovarian follicle developmentGO:000154110.1ICAM1, VEGFA
11calcium-mediated signaling using intracellular calcium sourceGO:003558410.0KDR, VCAM1
12induction of positive chemotaxisGO:00509309.8AGER, VEGFA
13regulation of immune responseGO:00507769.7ICAM1, SELL, VCAM1
14regulation of cell shapeGO:00083609.7ICAM1, KDR, VEGFA
15cellular response to vascular endothelial growth factor stimulusGO:00359249.6KDR, VCAM1, VEGFA
16response to lipopolysaccharideGO:00324969.6ICAM1, MPO, VCAM1
17response to hypoxiaGO:00016669.4ICAM1, VCAM1, VEGFA
18negative regulation of endothelial cell migrationGO:00105969.4AGER, SERPINF1
19positive regulation of protein phosphorylationGO:00019349.3AGER, KDR, VEGFA
20agingGO:00075689.3MPO, SERPINF1, VCAM1
21cellular response to glucose stimulusGO:00713339.2AGER, ICAM1, SERPINF1
22extracellular matrix organizationGO:00301989.0ICAM1, ITGAM, KDR, VCAM1
23leukocyte migrationGO:00509008.8ICAM1, ITGAM, SELL
24cell adhesionGO:00071558.6ICAM1, ITGAM, SELL, VCAM1

Molecular functions related to Leukostasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1integrin bindingGO:00051789.3ICAM1, KDR, VCAM1
2heparin bindingGO:00082018.3AGER, MPO, SELL, VEGFA

Sources for Leukostasis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet