Aliases & Classifications for Leukostasis

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Sources:
10Disease Ontology, 47Novoseek, 12DISEASES, 65UMLS, 36MeSH, 42NCIt, 59SNOMED-CT
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Aliases & Descriptions for Leukostasis:

Name: Leukostasis 10 47 12 65 36


Classifications:



External Ids:

Disease Ontology10 DOID:12986
MeSH36 D018921
SNOMED-CT59 30419000
NCIt42 C4062

Summaries for Leukostasis

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Wikipedia:68 Leukostasis (aka symptomatic hyperleukocytosis) is a white blood cell count above 100,000/╬╝L. It is... more...

MalaCards based summary: Leukostasis is related to thrombocytopenia and leukemia. An important gene associated with Leukostasis is ICAM1 (Intercellular Adhesion Molecule 1), and among its related pathways are Immune response_MIF-mediated glucocorticoid regulation and Immune response_Role of integrins in NK cells cytotoxicity. Affiliated tissues include lung, brain and myeloid, and related mouse phenotypes are muscle and vision/eye.

Related Diseases for Leukostasis

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Diseases related to Leukostasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 115)
idRelated DiseaseScoreTop Affiliating Genes
1thrombocytopenia29.7ICAM1, SELE, VCAM1, VEGFA
2leukemia10.8
3retinitis10.6
4myeloid leukemia10.5
5granulocytopenia10.4
6ischemia10.4
7endotheliitis10.3
8hepatitis10.3
9respiratory failure10.3
10maxillary sinus inverted papilloma10.2ICAM1, VCAM1
11liver cirrhosis10.2ICAM1, VCAM1
12anaerobic pneumonia10.2ICAM1, SELE
13breast epithelioid hemangioma10.2ICAM1, VCAM1
14anal paget's disease10.2ICAM1, MPO
15acute leukemia10.2
16mantle cell lymphoma10.2
17cerebritis10.2
18pneumonia10.2
19hypersensitivity reaction type iv disease10.2ICAM1, MPO
20postencephalitic parkinson disease10.1ICAM1, SELE
21abnormality of glucagon secretion10.1ICAM1, SELE
22cutaneous photosensitivity and colitis, lethal10.1SELE, VCAM1
23ventricular septal defect10.1ICAM1, VCAM1
24anatomical narrow angle borderline glaucoma10.1SERPINF1, VEGFA
25dengue hemorrhagic fever10.1ICAM1, VCAM1
26cowper gland carcinoma10.1SERPINF1, VEGFA
27breast fibroadenosis10.1ICAM1, SELE
28indolent systemic mastocytosis10.1KDR, VEGFA
29oral pharyngeal disorders10.1ICAM1, VCAM1
30early-onset, autosomal dominant alzheimer disease10.1SERPINF1, VEGFA
31gestational diabetes10.1AGER, SELE
32carbohydrate metabolic disorder10.1KDR, VEGFA
33polyneuropathy mental retardation acromicria premature menopause10.1ICAM1, VCAM1
34protein c deficiency10.1SERPINF1, VEGFA
35skin melanoma10.1KDR, VEGFA
36hypospadias - hypertelorism - coloboma and deafness10.1KDR, VEGFA
37warty dyskeratoma10.1KDR, VEGFA
38distal biliary tract carcinoma10.1ICAM1, SELE
39non-syndromic x-linked intellectual disability10.1ICAM1, VCAM1
40heart lymphoma10.1KDR, VEGFA
41discitis10.1KDR, VEGFA
42meningovascular neurosyphilis10.1ICAM1, SELL
43uterine corpus diffuse leiomyomatosis10.1MPO, VEGFA
44vascular disease10.1KDR, VEGFA
45chromoblastomycosis10.0ICAM1, SELL
46glomangioma10.0MPO, VEGFA
47male reproductive organ benign neoplasm10.0ICAM1, SERPINF1, VEGFA
48vestibule of mouth cancer10.0ICAM1, SERPINF1, VEGFA
49lymphoma aidsrelated10.0ICAM1, SELE, VCAM1
50inflammatory liposarcoma10.0ICAM1, SELE, VCAM1

Graphical network of the top 20 diseases related to Leukostasis:



Diseases related to leukostasis

Symptoms for Leukostasis

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Drugs & Therapeutics for Leukostasis

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Leukostasis


Cochrane evidence based reviews: Leukostasis

Genetic Tests for Leukostasis

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Anatomical Context for Leukostasis

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MalaCards organs/tissues related to Leukostasis:

33
Lung, Brain, Myeloid, Endothelial, Neutrophil, Monocytes, Bone

Animal Models for Leukostasis or affiliated genes

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MGI Mouse Phenotypes related to Leukostasis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.6AGER, ICAM1, KDR, MPO, VEGFA
2MP:00053918.0ICAM1, KDR, SELE, SERPINF1, VEGFA
3MP:00107717.3AGER, ICAM1, KDR, SELE, SELL, VEGFA
4MP:00053787.1AGER, ICAM1, KDR, SELE, SELL, VCAM1
5MP:00053976.6AGER, ICAM1, KDR, MPO, SELE, SELL
6MP:00053766.5AGER, ICAM1, KDR, MPO, SELE, SELL
7MP:00053876.3AGER, ICAM1, KDR, MPO, SELE, SELL
8MP:00053856.3AGER, ICAM1, KDR, MPO, SELE, SELL

Publications for Leukostasis

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Articles related to Leukostasis:

(show top 50)    (show all 109)
idTitleAuthorsYear
1
Leukostasis Retinopathy: A New Clinical Manifestation of Chronic Myeloid Leukemia With Severe Hyperleukocytosis. (26247460)
2015
2
NFAT isoforms play distinct roles in TNFI+-induced retinal leukostasis. (26527057)
2015
3
Leukostasis in Children and Adolescents with Chronic Myeloid Leukemia: Japanese Pediatric Leukemia/Lymphoma Study Group. (26485422)
2015
4
Pathologic rupture of the spleen in a patient with acute myelogenous leukemia and leukostasis. (25031169)
2014
5
Transfusion medicine illustrated. Catastrophic basilar artery leukostasis in the setting of acute myeloid leukemia. (24724788)
2014
6
Genetic mutations in patients with acute myeloid leukemia and leukostasis. (23548579)
2013
7
Leukostasis in an Adult with AML Presenting as Multiple High Attenuation Brain Masses on CT. (24551717)
2013
8
CD11b+ bone marrow-derived monocytes are the major leukocyte subset responsible for retinal capillary leukostasis in experimental diabetes in mouse and express high levels of CCR5 in the circulation. (22677420)
2012
9
Hyperleukocytosis, leukostasis and leukapheresis: practice management. (22364832)
2012
10
Reversal of leukostasis-related pulmonary distress syndrome after leukapheresis and low-dose chemotherapy in acute myeloid leukemia. (21825265)
2011
11
Rapid treatment of leukostasis in leukemic mantle cell lymphoma using therapeutic leukapheresis: a case report. (22224069)
2011
12
Phosphomannopentaose sulfate (PI-88) inhibits retinal leukostasis in diabetic rat. (19250642)
2009
13
Targeting leukostasis for the treatment of early diabetic retinopathy. (19619127)
2009
14
Reliability of leukostasis grading score to identify patients with high-risk hyperleukocytosis. (19391131)
2009
15
Leukostasis and pigment epithelium-derived factor in rat models of diabetic retinopathy. (17653050)
2007
16
Role of NADPH oxidase and ANG II in diabetes-induced retinal leukostasis. (17652361)
2007
17
Correlation between expression of CD56/NCAM and severe leukostasis in hyperleukocytic acute myelomonocytic leukaemia. (16519701)
2006
18
Intravitreal injection of corticosteroid attenuates leukostasis and vascular leakage in experimental diabetic retina. (15790913)
2005
19
Case report: mantle cell lymphoma, prolymphocytoid variant, with leukostasis syndrome. (15197401)
2004
20
Management of life-threatening pulmonary leukostasis with single agent imatinib mesylate during CML myeloid blast crisis. (15377482)
2004
21
The role of advanced glycation end products in retinal microvascular leukostasis. (14507893)
2003
22
Pulmonary leukostasis and the inhibition of airway neutrophil recruitment are early events in the endotoxemic rat. (11837792)
2002
23
Effective and selective prevention of retinal leukostasis in streptozotocin-induced diabetic rats using gliclazide. (12107755)
2002
24
Leukapheresis in chronic myelomonocytic leukemia with leukostasis syndrome: elevated serum lactate levels as an early sign of microcirculation failure. (12389624)
2002
25
Integrin-mediated neutrophil adhesion and retinal leukostasis in diabetes. (10752954)
2000
26
Pulmonary leukostasis mimicking pulmonary embolism. (10654454)
2000
27
Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition. (10485912)
1999
28
Use of genetically manipulated strains of Clostridium perfringens reveals that both alpha-toxin and theta-toxin are required for vascular leukostasis to occur in experimental gas gangrene. (10456947)
1999
29
Pressure-related capillary leukostasis following ischemia-reperfusion and hemorrhagic shock. (8342655)
1993
30
Involvement of the complement system in the pathogenesis of pulmonary leukostasis in experimental myelocytic leukemia. (8412322)
1993
31
Acute leukostasis pulmonary distress syndrome. (1402733)
1992
32
Pulmonary leukostasis secondary to all-trans retinoic acid in the treatment of acute promyelocytic leukemia in first relapse. (1602800)
1992
33
Pulmonary leukostasis without hyperleukocytosis: a clinicopathologic study of 16 cases. (1566743)
1992
34
Development of pulmonary leukostasis in experimental myelocytic leukemia in the Brown-Norway rat. (1552745)
1992
35
The state of leucocyte adhesiveness/aggregation (LAA) in the peripheral blood of burned mice: an early and sensitive inflammatory indicator and a marker of pulmonary leukostasis. (1793493)
1991
36
Effects of cardiopulmonary bypass on pulmonary leukostasis and complement activation. (3190431)
1988
37
Interleukin-1-induced granulocytopenia and pulmonary leukostasis in rabbits. (3031000)
1987
38
Quantitative estimation of leukostasis in the posttraumatic lung--canine and human autopsy data. (3615443)
1987
39
Pulmonary leukostasis in a patient with chronic myeloid leukemia. (3475250)
1986
40
Aleukaemic leukostasis in a case of large cell non-Hodgkin's lymphoma: report of a case with a distinctive central nervous system involvement. (3760899)
1986
41
Streptococcus pneumoniae-induced alterations in levels of circulating thromboxane and prostacyclin: dissociation from granulocytopenia, thrombocytopenia, and pulmonary leukostasis. (3510262)
1986
42
Intravascular leukostasis in a horse with myelomonocytic leukemia. (6592873)
1984
43
Reversal of hemodialysis granulocytopenia and pulmonary leukostasis: A clinical manifestation of selective down-regulation of granulocyte responses to C5adesarg. (7229031)
1981
44
Pneumococcus-induced granulocytopenia and pulmonary leukostasis in rabbits. (7452094)
1981
45
Complement-induced vascular leukostasis. Its role in tissue injury. (6893656)
1980
46
Pulmonary leukostasis and its relationship to pulmonary dysfunction in sheep and rabbits. (7351034)
1980
47
Leukostasis in SAczary syndrome. (439311)
1979
48
Rapid cytoreduction in acute leukemia. Management of cerebral leukostasis by cell pheresis. (272799)
1978
49
Hydroxyurea in the prevention of the effects of leukostasis in acute leukemia. (268956)
1977
50
Hemodialysis leukopenia. Pulmonary vascular leukostasis resulting from complement activation by dialyzer cellophane membranes. (856872)
1977

Variations for Leukostasis

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Expression for genes affiliated with Leukostasis

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Search GEO for disease gene expression data for Leukostasis.

Pathways for genes affiliated with Leukostasis

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Pathways related to Leukostasis according to GeneCards Suite gene sharing:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8ICAM1, VCAM1
29.8ICAM1, VCAM1
39.5KDR, VEGFA
4
Show member pathways
9.5KDR, VEGFA
5
Angiogenesis (WikiPathways)
Show member pathways
9.5KDR, VEGFA
69.5KDR, VEGFA
79.5KDR, VEGFA
89.4ICAM1, MPO, VCAM1
99.3AGER, ICAM1, MPO
109.3ICAM1, KDR, VCAM1
11
VEGF Pathway (Qiagen)
Show member pathways
9.2ICAM1, KDR, VCAM1
129.2ICAM1, SELL, VCAM1
139.0SELE, SELL
149.0ICAM1, SELE, VCAM1
159.0ICAM1, SELE, VCAM1
169.0ICAM1, SELE, VCAM1
179.0ICAM1, SELE, VCAM1
18
Show member pathways
8.7SELE, SELL, VCAM1
198.4ICAM1, SELE, SELL, VCAM1
20
Show member pathways
8.3SELE, SELL, VCAM1, VEGFA
21
Show member pathways
8.1ICAM1, KDR, SELE, VCAM1, VEGFA

GO Terms for genes affiliated with Leukostasis

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Cellular components related to Leukostasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.0ICAM1, KDR, SELL, VCAM1
2membrane raftGO:00451218.5ICAM1, KDR, SELE
3cell surfaceGO:00099868.2AGER, ICAM1, SELL, VCAM1, VEGFA
4extracellular spaceGO:00056157.2AGER, ICAM1, MPO, SELE, SERPINF1, VCAM1

Biological processes related to Leukostasis according to GeneCards Suite gene sharing:

(show all 35)
idNameGO IDScoreTop Affiliating Genes
1membrane to membrane dockingGO:002261410.4ICAM1, VCAM1
2negative regulation of endothelial cell apoptotic processGO:200035210.2ICAM1, KDR
3calcium-mediated signaling using intracellular calcium sourceGO:003558410.2KDR, VCAM1
4vascular endothelial growth factor signaling pathwayGO:003808410.2KDR, VEGFA
5cellular response to vascular endothelial growth factor stimulusGO:003592410.2KDR, VEGFA
6regulation of hematopoietic progenitor cell differentiationGO:190153210.2KDR, VEGFA
7positive regulation of positive chemotaxisGO:005092710.2KDR, VEGFA
8surfactant homeostasisGO:004312910.2KDR, VEGFA
9positive regulation of mesenchymal cell proliferationGO:000205310.2KDR, VEGFA
10cell migration involved in sprouting angiogenesisGO:000204210.2KDR, VEGFA
11positive regulation of focal adhesion assemblyGO:005189410.2KDR, VEGFA
12regulation of endothelial cell differentiationGO:004560110.2KDR, VEGFA
13branching morphogenesis of an epithelial tubeGO:004875410.1KDR, VEGFA
14cell maturationGO:004846910.1KDR, VEGFA
15positive regulation of endothelial cell migrationGO:001059510.1KDR, VEGFA
16negative regulation of endothelial cell migrationGO:001059610.1AGER, SERPINF1
17induction of positive chemotaxisGO:005093010.0AGER, VEGFA
18response to hyperoxiaGO:00550939.9AGER, SELL
19leukocyte tethering or rollingGO:00509019.9SELE, VCAM1
20calcium ion homeostasisGO:00550749.9AGER, KDR
21positive regulation of leukocyte migrationGO:00026879.8SELE, VEGFA
22positive regulation of receptor internalizationGO:00020929.8SELE, VEGFA
23regulation of cell shapeGO:00083609.5ICAM1, KDR, VEGFA
24cellular response to glucose stimulusGO:00713339.5AGER, ICAM1, SERPINF1
25heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesGO:00071579.5ICAM1, SELE, VCAM1
26ovarian follicle developmentGO:00015419.5ICAM1, KDR, VEGFA
27positive regulation of protein phosphorylationGO:00019349.5AGER, KDR, VEGFA
28leukocyte cell-cell adhesionGO:00071599.5ICAM1, SELE, VCAM1
29positive regulation of cell migrationGO:00303359.4AGER, KDR, VEGFA
30positive regulation of ERK1 and ERK2 cascadeGO:00703749.4ICAM1, KDR, VEGFA
31response to hypoxiaGO:00016669.4AGER, ICAM1, VEGFA
32lung developmentGO:00303249.3AGER, KDR, VEGFA
33regulation of immune responseGO:00507769.2ICAM1, SELL, VCAM1
34leukocyte migrationGO:00509009.0ICAM1, SELE, SELL
35cell adhesionGO:00071558.3ICAM1, SELE, SELL, VCAM1

Molecular functions related to Leukostasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1integrin bindingGO:00051789.3ICAM1, KDR, VCAM1
2transmembrane signaling receptor activityGO:00048889.0AGER, ICAM1, SELE
3heparin bindingGO:00082018.8MPO, SELL, VEGFA

Sources for Leukostasis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet