MCID: LKS001
MIFTS: 48

Leukostasis malady

Summaries for Leukostasis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Leukostasis (aka symptomatic hyperleukocytosis) is a white blood cell count above 100,000/μL. It is... more...

MalaCards: Leukostasis is related to leukemia and acute leukemia. An important gene associated with Leukostasis is SELE (selectin E), and among its related pathways are Cell adhesion molecules (CAMs) and Signaling by VEGF. The compounds pge2 and okt3 have been mentioned in the context of this disorder. Affiliated tissues include lung, brain and myeloid, and related mouse phenotypes are vision/eye and no phenotypic analysis.

Aliases & Classifications for Leukostasis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT
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Aliases & Descriptions:

leukostasis 8 10 44 60


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Disease Ontology8 DOID:12986
MeSH34 D018921
SNOMED-CT56 30419000
NCIt39 C4062

Related Diseases for Leukostasis

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17GeneCards, 18GeneDecks
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Diseases related to Leukostasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 181)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia30.9ICAM1, TNF, MPO, KDR, SERPINF1, C5AR1
2acute leukemia30.7MPO
3ischemia30.3ICAM1, MPO, VEGFA, KDR, SELE, C5AR1
4diabetic retinopathy30.3ICAM1, AGER, VEGFA, KDR, VCAM1, SERPINF1
5myeloid leukemia30.3MPO
6pneumonia30.0C5AR1, MPO, TNF, ICAM1
7monocytic leukemia29.8VCAM1, TNF
8hypertension29.8ICAM1, VCAM1, SELE
9tuberculosis29.8C5AR1, TNF
10retinal ischemia29.8VEGFA
11retinitis10.5
12acute myeloid leukemia10.1
13hepatitis10.1
14respiratory failure10.1
15central nervous system lymphoma10.1
16cerebritis10.1
17central nervous system leukemia10.1
18mantle cell lymphoma10.1
19childhood leukemia10.1
20acute myocardial infarction10.0SELE
21kawasaki disease10.0SELE
22atopy10.0MPO
23pulmonary fibrosis10.0MPO
24acute pancreatitis10.0MPO
25severe pre-eclampsia10.0VCAM1
26myelodysplastic syndromes10.0MPO
27sjogren's syndrome10.0ICAM1
28pleurisy10.0MPO
29glaucoma10.0SERPINF1
30bronchiectasis10.0MPO
31myocardial infarction10.0AGER
32polycystic ovary syndrome10.0AGER
33essential hypertension10.0AGER
34dementia10.0AGER
35cataract10.0SERPINF1
36chorioamnionitis10.0TNF
37crohn's disease10.0TNF
38schizophrenia10.0AGER
39ankylosing spondylitis10.0TNF
40macular holes10.0SERPINF1
41hypercholesterolemia10.0VCAM1, SELE
42sarcoma10.0KDR
43nephritis10.0MPO, VCAM1
44sickle cell disease10.0SELE, VCAM1
45wegener's granulomatosis10.0SELE, MPO
46familial mediterranean fever10.0TNF
47antiphospholipid syndrome10.0SELE, VCAM1
48rhinitis10.0ICAM1, VCAM1
49hypertriglyceridemia10.0SELE, VCAM1
50dermatomyositis10.0ICAM1, VCAM1

Graphical network of the top 20 diseases related to Leukostasis:



Diseases related to leukostasis

Clinical Features for Leukostasis

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Drugs & Therapeutics for Leukostasis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Leukostasis

Drug clinical trials:

Search ClinicalTrials for Leukostasis

Search NIH Clinical Center for Leukostasis

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Genetic Tests for Leukostasis

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Anatomical Context for Leukostasis

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32MalaCards
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MalaCards organs/tissues related to Leukostasis:

32
Lung, Brain, Myeloid, Endothelial, Monocytes, Bone, Retina

Animal Models for Leukostasis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Leukostasis:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053919.9SERPINF1, SELE
2MP:00030129.5KDR, AGER
3MP:00107719.4VEGFA, KDR
4MP:00053769.1ICAM1, VCAM1, SELE, C5AR1
5MP:00053858.9SERPINF1, SELE, VCAM1, AGER, MPO
6MP:00053697.5ICAM1, TNF, MPO, AGER, VEGFA, KDR
7MP:00053847.0ICAM1, TNF, AGER, VEGFA, KDR, VCAM1
8MP:00053786.8ICAM1, TNF, AGER, VEGFA, KDR, VCAM1
9MP:00107686.6ICAM1, TNF, MPO, VEGFA, KDR, VCAM1
10MP:00053976.4ICAM1, TNF, MPO, AGER, VEGFA, KDR
11MP:00053876.4ICAM1, TNF, MPO, AGER, VEGFA, KDR

Publications for Leukostasis

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50PubMed
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Articles related to Leukostasis:

(show top 50)    (show all 101)
idTitleAuthorsYear
1
CD11b+ bone marrow-derived monocytes are the major leukocyte subset responsible for retinal capillary leukostasis in experimental diabetes in mouse and express high levels of CCR5 in the circulation. (22677420)
2012
2
Reversal of leukostasis-related pulmonary distress syndrome after leukapheresis and low-dose chemotherapy in acute myeloid leukemia. (21825265)
2011
3
Rapid treatment of leukostasis in leukemic mantle cell lymphoma using therapeutic leukapheresis: a case report. (22224069)
2011
4
Therapeutic leukapheresis in patients with leukostasis secondary to acute myelogenous leukemia. (21574176)
2011
5
TNFalpha is required for late BRB breakdown in diabetic retinopathy, and its inhibition prevents leukostasis and protects vessels and neurons from apoptosis. (21212173)
2011
6
Phosphomannopentaose sulfate (PI-88) inhibits retinal leukostasis in diabetic rat. (19250642)
2009
7
Inhibition of diabetic leukostasis and blood-retinal barrier breakdown with a soluble form of a receptor for advanced glycation end products. (17251488)
2007
8
Images in clinical medicine. FLT3 Mutation and acute myelogenous leukemia with leukostasis. (17942876)
2007
9
A case report of therapeutic leukapheresis in an adult with chronic myelogenous leukemia presenting with hyperleukocytosis and leukostasis. (17381536)
2007
10
Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood-retinal barrier breakdown in diabetic retinopathy. (17962481)
2007
11
Correlation between expression of CD56/NCAM and severe leukostasis in hyperleukocytic acute myelomonocytic leukaemia. (16519701)
2006
12
Grading of symptoms in hyperleukocytic leukaemia: a clinical model for the role of different blast types and promyelocytes in the development of leukostasis syndrome. (15876254)
2005
13
Case report: mantle cell lymphoma, prolymphocytoid variant, with leukostasis syndrome. (15197401)
2004
14
Pulmonary leukostasis and the inhibition of airway neutrophil recruitment are early events in the endotoxemic rat. (11837792)
2002
15
Leukapheresis in chronic myelomonocytic leukemia with leukostasis syndrome: elevated serum lactate levels as an early sign of microcirculation failure. (12389624)
2002
16
The irreplaceable image: Cerebral leukostasis manifesting as multifocal intracerebral hemorrhage. (11694415)
2001
17
Hyperleukocytic leukemias and leukostasis: a review of pathophysiology, clinical presentation and management. (10975379)
2000
18
Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition. (10485912)
1999
19
Use of genetically manipulated strains of Clostridium perfringens reveals that both alpha-toxin and theta-toxin are required for vascular leukostasis to occur in experimental gas gangrene. (10456947)
1999
20
T-lymphocytes contribute to hepatic leukostasis and hypoxic stress induced by gut ischemia-reperfusion. (10654278)
1999
21
Transgenic mice with increased copper/zinc-superoxide dismutase activity are resistant to hepatic leukostasis and capillary no-reflow after gut ischemia/reperfusion. (9758638)
1998
22
Central nervous system leukostasis in patients with leukemias and lymphomas. (8673423)
1995
23
Endotoxin-induced pulmonary leukostasis in the rat: role of platelet-activating factor and tumor necrosis factor. (8288963)
1994
24
Pressure-related capillary leukostasis following ischemia-reperfusion and hemorrhagic shock. (8342655)
1993
25
Involvement of the complement system in the pathogenesis of pulmonary leukostasis in experimental myelocytic leukemia. (8412322)
1993
26
Endothelial activation antigens in pulmonary leukostasis in leukemia. (8237271)
1993
27
Pulmonary leukostasis secondary to all-trans retinoic acid in the treatment of acute promyelocytic leukemia in first relapse. (1602800)
1992
28
Development of pulmonary leukostasis in experimental myelocytic leukemia in the Brown-Norway rat. (1552745)
1992
29
The state of leucocyte adhesiveness/aggregation (LAA) in the peripheral blood of burned mice: an early and sensitive inflammatory indicator and a marker of pulmonary leukostasis. (1793493)
1991
30
Experimental myelocytic leukemia in the Brown-Norway rat as a model for pulmonary leukostasis. (2000946)
1991
31
Interleukin-1-induced granulocytopenia and pulmonary leukostasis in rabbits. (3031000)
1987
32
Pulmonary leukostasis: radiologic-pathologic study. (3479813)
1987
33
High-voltage irradiation and hydroxyurea for pulmonary leukostasis in acute myelomonocytic leukemia. (3113160)
1987
34
Aleukaemic leukostasis in a case of large cell non-Hodgkin's lymphoma: report of a case with a distinctive central nervous system involvement. (3760899)
1986
35
Streptococcus pneumoniae-induced alterations in levels of circulating thromboxane and prostacyclin: dissociation from granulocytopenia, thrombocytopenia, and pulmonary leukostasis. (3510262)
1986
36
Leukostasis thrombi. (4009895)
1985
37
Pulmonary leukostasis as the single worst prognostic factor in patients with acute myelocytic leukemia and hyperleukocytosis. (3860006)
1985
38
Intravascular leukostasis in a horse with myelomonocytic leukemia. (6592873)
1984
39
Pneumococcal-induced pulmonary leukostasis and hemodynamic changes: role of complement and granulocytes. (6693792)
1984
40
Pulmonary leukostasis in fatal human pneumococcal bacteremia without pneumonia. (6508013)
1984
41
Pneumococcal sonicate-induced biphasic granulocytopenia and its dissociation from pulmonary leukostasis. The contribution of pneumococcal products and complement to early and late granulocytopenic phases. (6644159)
1983
42
Respiratory failure due to pulmonary leukostasis following chemotherapy of acute nonlymphocytic leukemia. (6831346)
1983
43
Respiratory failure due to leukostasis in leukaemia. (6946277)
1981
44
Complement-induced vascular leukostasis. Its role in tissue injury. (6893656)
1980
45
Pulmonary leukostasis and its relationship to pulmonary dysfunction in sheep and rabbits. (7351034)
1980
46
Leukostasis in SAczary syndrome. (439311)
1979
47
Rapid cytoreduction in acute leukemia. Management of cerebral leukostasis by cell pheresis. (272799)
1978
48
Leukostasis associated with blood transfusion in acute myeloid leukaemia. (273461)
1978
49
Hydroxyurea in the prevention of the effects of leukostasis in acute leukemia. (268956)
1977
50
Hemodialysis leukopenia. Pulmonary vascular leukostasis resulting from complement activation by dialyzer cellophane membranes. (856872)
1977

Genetic Variations for Leukostasis

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Expression for genes affiliated with Leukostasis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Leukostasis

Search GEO for disease gene expression data for Leukostasis.

Pathways for genes affiliated with Leukostasis

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29KEGG, 53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 51QIAGEN
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Compounds for genes affiliated with Leukostasis

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44Novoseek, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Leukostasis according to GeneCards/GeneDecks:

(show top 50)    (show all 138)
idCompoundScoreTop Affiliating Genes
1pge24410.3VEGFA
2okt34410.2ICAM1, VCAM1
3triamcinolone acetonide44 2811.2SERPINF1
4matrigel4410.1SELE, KDR
5ulinastatin4410.0MPO, ICAM1
6diphenyleneiodonium449.8SERPINF1, VCAM1, MPO
78 methoxypsoralen449.7SELE, VCAM1, ICAM1
8sele449.7ICAM1, VCAM1, SELE
9prednisolone44 28 1111.7MPO, C5AR1
10troglitazone44 28 59 1112.5SELE, ICAM1, VCAM1
11ro 31-7549449.4TNF, VCAM1, SELE
12cobalt chloride449.4VEGFA, SELE, VCAM1
13hcec449.4KDR, ICAM1, VCAM1
14celastrol44 5910.4SELE, VCAM1, TNF
15slex449.2VCAM1, ICAM1, SELE
16dexamethasone44 49 28 1112.1VEGFA, SERPINF1, KDR
17fluticasone propionate44 49 59 1112.1TNF, MPO, VCAM1, SELE
18polymyxin b449.1SELE, VCAM1, TNF, ICAM1
19groalpha449.1VCAM1, TNF, ICAM1, SELE
20rantes449.1C5AR1, ICAM1, TNF
21sulfasalazine44 28 49 1112.0ICAM1, TNF, MPO, SELE
22budesonide44 49 1111.0VCAM1, MPO, ICAM1, TNF
23fenofibrate44 49 1111.0TNF, ICAM1, VCAM1, SELE
24fluorescein44 1110.0MPO, C5AR1, SERPINF1, VEGFA
25gliclazide44 49 1111.0SELE, VEGFA, MPO, ICAM1, VCAM1
26pdtc449.0VCAM1, TNF, ICAM1, SELE
27pentoxifylline44 119.9ICAM1, MPO, TNF, VCAM1
288-isoprostane448.7SELE, ICAM1, VCAM1, MPO, TNF
29n-formylmethionyl-leucylphenylalanine448.7C5AR1, MPO, ICAM1, TNF
30herbimycin a44 599.7VCAM1, TNF, ICAM1, SELE
31endotoxin448.5ICAM1, C5AR1, SELE, VCAM1, TNF
32atorvastatin44 49 28 11 2412.5TNF, SELE, VEGFA, VCAM1, ICAM1
33fmlp448.5VCAM1, ICAM1, TNF, C5AR1, MPO
34fibrinogen448.4TNF, ICAM1, SELE, C5AR1, VCAM1
35oxygen44 249.3ICAM1, TNF, MPO, SERPINF1, C5AR1
36histamine44 28 2410.2TNF, MPO, VCAM1, SELE, C5AR1, ICAM1
37lactate448.1VCAM1, SELE, ICAM1, TNF, MPO, KDR
38apocynin44 599.1ICAM1, TNF, MPO, VEGFA, VCAM1, SELE
39mg 13244 599.0TNF, ICAM1, VEGFA, KDR
40serine448.0AGER, TNF, C5AR1, SERPINF1, SELE, MPO
41simvastatin44 49 59 28 11 2412.9SELE, ICAM1, TNF, VEGFA, KDR, VCAM1
42sb 20358044 598.9VCAM1, VEGFA, C5AR1, TNF, ICAM1, SELE
43heparin44 28 11 2410.9AGER, C5AR1, VCAM1, SELE, VEGFA, MPO
44ly294002447.9SELE, VCAM1, KDR, VEGFA, TNF, ICAM1
45genistein44 28 59 2 11 2412.9ICAM1, TNF, SELE, VEGFA, KDR, VCAM1
46h2o2447.8TNF, SERPINF1, C5AR1, KDR, MPO, ICAM1
47prostacyclin447.0VCAM1, SELE, C5AR1, KDR, VEGFA, TNF
48nitric oxide44 11 248.8C5AR1, ICAM1, TNF, MPO, AGER, KDR
49n acetylcysteine446.8TNF, VCAM1, SELE, SERPINF1, VEGFA, AGER
50vegf446.2AGER, VCAM1, C5AR1, SELE, SERPINF1, KDR

GO Terms for genes affiliated with Leukostasis

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16Gene Ontology
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Cellular components related to Leukostasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membrane raftGO:0451218.7KDR, SELE, TNF
2external side of plasma membraneGO:0098978.5KDR, TNF, ICAM1, VCAM1
3cell surfaceGO:0099868.2VEGFA, VCAM1, C5AR1, TNF
4integral to plasma membraneGO:0058877.5TNF, KDR, C5AR1, AGER, ICAM1
5extracellular spaceGO:0056157.4SERPINF1, ICAM1, TNF, MPO, VEGFA, VCAM1
6plasma membraneGO:0058867.2ICAM1, AGER, KDR, VCAM1, SELE, C5AR1

Biological processes related to Leukostasis according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1membrane to membrane dockingGO:02261410.1VCAM1, ICAM1
2positive regulation of leukocyte migrationGO:0026879.8SELE, VEGFA
3leukocyte cell-cell adhesionGO:0071599.8SELE, VCAM1, ICAM1
4heterophilic cell-cell adhesionGO:0071579.8ICAM1, VCAM1, SELE
5positive regulation of receptor internalizationGO:0020929.7VEGFA, SELE
6surfactant homeostasisGO:0431299.6KDR, VEGFA
7positive regulation of positive chemotaxisGO:0509279.6KDR, VEGFA
8positive regulation of focal adhesion assemblyGO:0518949.6VEGFA, KDR
9induction of positive chemotaxisGO:0509309.6VEGFA, AGER
10cell migration involved in sprouting angiogenesisGO:0020429.6KDR, VEGFA
11negative regulation of growth of symbiont in hostGO:0441309.5MPO, TNF
12cellular response to glucose stimulusGO:0713339.5VCAM1, ICAM1
13leukocyte tethering or rollingGO:0509019.4SELE, VCAM1, TNF
14cellular response to vascular endothelial growth factor stimulusGO:0359249.4KDR, VEGFA
15vascular endothelial growth factor receptor signaling pathwayGO:0480109.3VEGFA, KDR
16ovarian follicle developmentGO:0015419.3KDR, VEGFA, ICAM1
17positive regulation of nitric oxide biosynthetic processGO:0454299.3TNF, ICAM1
18positive regulation of protein complex assemblyGO:0313349.3TNF, VEGFA
19regulation of cell shapeGO:0083609.2ICAM1, VEGFA, KDR
20branching morphogenesis of an epithelial tubeGO:0487549.2KDR, VEGFA
21positive regulation of NF-kappaB transcription factor activityGO:0510929.1AGER, TNF, ICAM1
22positive regulation of ERK1 and ERK2 cascadeGO:0703748.9TNF, KDR, C5AR1
23positive regulation of protein phosphorylationGO:0019348.8KDR, VEGFA, TNF
24response to hypoxiaGO:0016668.8VCAM1, VEGFA, TNF
25inflammatory responseGO:0069548.7TNF, AGER, SELE, C5AR1

Molecular functions related to Leukostasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:0048889.3SELE, AGER, ICAM1
2integrin bindingGO:0051789.0VCAM1, KDR, ICAM1

Products for genes affiliated with Leukostasis

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Sources for Leukostasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet