Aliases & Classifications for Leukostasis

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Aliases & Descriptions for Leukostasis:

Name: Leukostasis 10 47 12 36 65

Classifications:



External Ids:

Disease Ontology10 DOID:12986
MeSH36 D018921
SNOMED-CT59 30419000
NCIt42 C4062
UMLS65 C0282548

Summaries for Leukostasis

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Wikipedia:68 Leukostasis (aka symptomatic hyperleukocytosis) is a white blood cell count above 100,000/╬╝L. It is... more...

MalaCards based summary: Leukostasis is related to food allergy and breast cancer. An important gene associated with Leukostasis is ICAM1 (Intercellular Adhesion Molecule 1), and among its related pathways are Immune response_MIF-mediated glucocorticoid regulation and LDL Oxidation in Atherogenesis. Affiliated tissues include lung, brain and liver, and related mouse phenotypes are muscle and vision/eye.

Related Diseases for Leukostasis

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Diseases related to Leukostasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 150)
idRelated DiseaseScoreTop Affiliating Genes
1food allergy29.9ICAM1, SELE
2breast cancer10.3
3plasma cell neoplasm10.3ICAM1, VCAM1
4liver cirrhosis10.3ICAM1, VCAM1
5monckeberg arteriosclerosis10.3ICAM1, VCAM1
6exudative glomerulonephritis10.2ICAM1, MPO
7leukemia10.2
8meconium aspiration syndrome10.2ICAM1, MPO
9angioedema10.2ICAM1, MPO
10crescentic glomerulonephritis10.2ICAM1, MPO
11colon carcinoma in situ10.2ICAM1, SELE
12oral pharyngeal disorders10.2ICAM1, VCAM1
13solar retinopathy10.2ICAM1, SELE
14timothy grass allergy10.2ICAM1, MPO
15diphyllobothriasis10.2ICAM1, SELE
16dengue hemorrhagic fever10.2ICAM1, VCAM1
17intra-abdominal lymph node mast cell malignancy10.2ICAM1, SELE
18scarlet fever10.2ITGAM, MPO
19colorectal cancer10.2
20autosomal dominant cerebellar ataxia10.2ICAM1, SELE
21polyneuropathy mental retardation acromicria premature menopause10.1ICAM1, VCAM1
22tuberculoid leprosy10.1ICAM1, MPO
23gestational diabetes10.1AGER, SELE
24bladder urachal squamous cell carcinoma10.0KDR, VEGFA
25suprasellar meningioma10.0SERPINF1, VEGFA
26villonodular synovitis10.0ITGAM, MPO
27meningocele10.0KDR, VEGFA
28dyskeratosis congenita10.0KDR, VEGFA
29protein s deficiency10.0SERPINF1, VEGFA
30gastric neuroendocrine neoplasm10.0KDR, VEGFA
31qualitative platelet defect10.0ICAM1, MPO, VCAM1
32schizophrenia10.0
33hiv-110.0
34hepatocellular carcinoma10.0
35obesity10.0
36multiple system atrophy10.0
37beckwith-wiedemann syndrome10.0
38tetralogy of fallot10.0
39otitis media10.0
40pancreatic cancer10.0
41retinoschisis10.0
42cerebral palsy10.0
43osteoarthritis10.0
44sinusitis10.0
45ulcerative colitis10.0
46periventricular nodular heterotopia10.0
47sleep apnea10.0
48obstructive sleep apnea10.0
49lymphoma10.0
50colitis10.0

Graphical network of the top 20 diseases related to Leukostasis:



Diseases related to leukostasis

Symptoms for Leukostasis

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Drugs & Therapeutics for Leukostasis

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Leukostasis


Cochrane evidence based reviews: leukostasis

Genetic Tests for Leukostasis

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Anatomical Context for Leukostasis

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MalaCards organs/tissues related to Leukostasis:

33
Lung, Brain, Liver, Endothelial, Prostate, Spinal cord, Testes

Animal Models for Leukostasis or affiliated genes

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MGI Mouse Phenotypes related to Leukostasis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.2AGER, ICAM1, KDR, MPO, VEGFA
2MP:00053918.1ICAM1, KDR, SELE, SERPINF1, VEGFA
3MP:00053847.4AGER, ICAM1, ITGAM, KDR, SELE, VCAM1
4MP:00053766.8AGER, ICAM1, ITGAM, KDR, MPO, SELE
5MP:00053976.7AGER, ICAM1, ITGAM, KDR, MPO, SELE
6MP:00053856.5AGER, ICAM1, KDR, MPO, SELE, SERPINF1
7MP:00053876.4AGER, ICAM1, ITGAM, KDR, MPO, SELE

Publications for Leukostasis

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Articles related to Leukostasis:

(show top 50)    (show all 110)
idTitleAuthorsYear
1
An Unusual Case of YWHAE-NUTM2A/B Endometrial Stromal Sarcoma With Confinement to the Endometrium and Lack of High-Grade Morphology. (27171540)
2016
2
FBXL5 inhibits metastasis of gastric cancer through suppressing Snail1. (25832584)
2015
3
Expression and significance of circulating microRNA-31 in lung cancer patients. (25765717)
2015
4
Goldmann-Witmer, definitive diagnosis in unifocal helicoid choroiditis. (25443192)
2014
5
Tuberculosis mortality: patient characteristics and causes. (24387757)
2014
6
Inhibition of p38 MAPK signaling augments skin tumorigenesis via NOX2 driven ROS generation. (24824222)
2014
7
TLR2 and TLR4 expression in atopic dermatitis, contact dermatitis and psoriasis. (24661005)
2014
8
Primary intramedullary spinal cord germinoma. (23432481)
2013
9
Greater risk of parkinsonism associated with non-N370S GBA1 mutations. (22968580)
2013
10
miR-141 contributes to fetal growth restriction by regulating PLAG1 expression. (23554918)
2013
11
Management of psoriasis in pregnancy. (23914885)
2013
12
Intracellular distribution of the I9Np73 protein isoform in medulloblastoma cells: a study with newly generated rabbit polyclonal antibodies. (23338942)
2013
13
A female patient with depression and conversion disorder following brain tumor surgery. (23975697)
2013
14
RIG-I: a viral RNA detector molecular switch]. (22377296)
2012
15
Burden of community-acquired and nosocomial rotavirus gastroenteritis in the pediatric population of Western Europe: a scoping review. (22429601)
2012
16
Molecular cytogenetic characterization of undifferentiated embryonal sarcoma of the liver: a case report and literature review. (22551002)
2012
17
Eysenck's Two Big Personality Factors and Their Relationship to Depression in Patients with Chronic Idiopathic Pain Disorder: A Clinimetric Validation Analysis. (23738195)
2012
18
Inguinal hernia repair in patients with liver cirrhosis accompanied by ascites. (22066069)
2011
19
Role of polymorphic markers of antioxidants (NQO1, GSTP1, GPX1) genes in adaptive response to hazardous work conditions in workers]. (20480816)
2010
20
Frameshift mutation of MAPRE3, a microtubule-related gene, in gastric and colorectal cancers with microsatellite instability. (20632835)
2010
21
Matrix metalloprotease polymorphisms are associated with gas transfer in alpha 1 antitrypsin deficiency. (19293200)
2009
22
Febrile seizures: characterization of double-stranded RNA-induced gene expression. (19589459)
2009
23
Neuroleptic malignant syndrome with use of quetiapine in mental retardation. (19335404)
2009
24
Ectopic recurrence of dysplastic gangliocytoma of the cerebellum (Lhermitte-Duclos disease): a case report. (18095141)
2007
25
The role of Chlamydia trachomatis in prostatitis syndrome--our experience in diagnosis and treatment. (17868538)
2007
26
Expression of the Bax inhibitor-1 gene in pulmonary adenocarcinoma. (16353209)
2006
27
Repeat-region polymorphisms in the gene for the dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-related molecule: effects on HIV-1 susceptibility. (16453266)
2006
28
Improvement in C-reactive protein and advanced glycosylation end-products in poorly controlled diabetics is independent of glucose control. (16253380)
2006
29
The Ponseti technique for treatment of talipes equinovarus. (16598912)
2006
30
Functional FGFR4 Gly388Arg polymorphism predicts prognosis in lung adenocarcinoma patients. (16061909)
2005
31
The Pro387Leu variant of protein tyrosine phosphatase-1B is not associated with diabetes mellitus type 2 in a German population. (15715684)
2005
32
Chondrocyte protein with a poly-proline region (CHPPR) is a novel mitochondrial protein and promotes mitochondrial fission. (15389597)
2004
33
Correlation between neuronal injury and Caspase-3 after focal ischemia in human hippocampus. (15498374)
2004
34
Mediastinal immature teratoma with yolk sac tumor and myelomonocytic leukemia associated with Klinefelter's syndrome. (12075411)
2002
35
COL5A1 exon 14 splice acceptor mutation causes a functional null allele, haploinsufficiency of alpha 1(V) and abnormal heterotypic interstitial fibrils in Ehlers-Danlos syndrome II. (11278977)
2001
36
Quetiapine for tic disorder: a case report. (11853307)
2001
37
Undetectable prostate-specific antigen response with bicalutamide withdrawal phenomenon. (10963494)
2000
38
von Willebrand factor, fibrinogen and other plasma proteins as determinants of plasma viscosity. (9712338)
1998
39
Study of pulmonary experimental paracoccidioidomycosis by analysis of bronchoalveolar lavage cells: resistant vs. susceptible mice. (9750339)
1998
40
A novel mutation in the helix termination peptide of keratin 5 causing epidermolysis bullosa simplex Dowling-Meara. (9406827)
1997
41
Adult pancreatoblastoma: a case report and review of the literature. (8792711)
1996
42
rap1 p21 regulates the interaction of ras p21 with RGL, a new effector protein of ras p21. (7498475)
1995
43
More acquired immunodeficiency syndrome (AIDS) dementia complex in Japan? (8563090)
1995
44
Expression of cryptantigen Th on paroxysmal nocturnal hemoglobinuria erythrocytes in association with a hemolytic exacerbation. (7542278)
1995
45
Postcholecystectomy syndrome. How to determine if the sphincter of Oddi is the cause. (1546015)
1992
46
Richard Pearson Strong and the Manchurian epidemic of pneumonic plague, 1910-1911. (2671146)
1989
47
Massive osteolysis of the femur (Gorham's disease): a case report and review of the literature. (2677046)
1989
48
The provenance of the Swedish swine influenza H1N1 virus of 1983. (2829472)
1987
49
cDNA sequencing of nuclear lamins A and C reveals primary and secondary structural homology to intermediate filament proteins. (3462705)
1986
50
Streptococcal pharyngitis and scarlet fever. (655147)
1978

Variations for Leukostasis

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Expression for genes affiliated with Leukostasis

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Search GEO for disease gene expression data for Leukostasis.

Pathways for genes affiliated with Leukostasis

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Pathways related to Leukostasis according to GeneCards Suite gene sharing:

(show all 24)
idSuper pathwaysScoreTop Affiliating Genes
19.8ICAM1, VCAM1
29.4ICAM1, MPO, VCAM1
39.3ICAM1, SELE, VCAM1
49.3ICAM1, SELE, VCAM1
59.3ICAM1, SELE, VCAM1
69.3ICAM1, SELE, VCAM1
79.3ICAM1, ITGAM, VCAM1
8
Show member pathways
9.2KDR, VEGFA
99.2KDR, VEGFA
109.2KDR, VEGFA
119.2KDR, VEGFA
129.2KDR, VEGFA
139.2KDR, VEGFA
14
Show member pathways
9.1ITGAM, SELE, VCAM1
15
Show member pathways
8.9ITGAM, SELE, VCAM1
168.9KDR, VCAM1, VEGFA
17
Show member pathways
8.9ICAM1, ITGAM, KDR, VCAM1
18
Show member pathways
8.9ICAM1, ITGAM, KDR, VCAM1
198.8AGER, ICAM1, ITGAM, MPO
208.8ICAM1, ITGAM, SELE, VCAM1
218.1AGER, ICAM1, SELE, VCAM1, VEGFA
22
Show member pathways
8.1ICAM1, KDR, SELE, VCAM1, VEGFA
23
Show member pathways
8.1ICAM1, ITGAM, KDR, VCAM1, VEGFA
24
Show member pathways
8.1ICAM1, ITGAM, KDR, VCAM1, VEGFA

GO Terms for genes affiliated with Leukostasis

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Biological processes related to Leukostasis according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1leukocyte cell-cell adhesionGO:000715910.4ICAM1, VCAM1
2calcium-mediated signaling using intracellular calcium sourceGO:003558410.2KDR, VCAM1
3negative regulation of endothelial cell apoptotic processGO:200035210.1ICAM1, KDR
4interferon-gamma-mediated signaling pathwayGO:006033310.1ICAM1, VCAM1
5heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesGO:000715710.1ICAM1, SELE
6cell migration involved in sprouting angiogenesisGO:00020429.8KDR, VEGFA
7positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathwayGO:00380339.8KDR, VEGFA
8ovarian follicle developmentGO:00015419.7ICAM1, VEGFA
9vasculogenesisGO:00015709.5KDR, VEGFA
10positive regulation of receptor internalizationGO:00020929.5SELE, VEGFA
11negative regulation of endothelial cell migrationGO:00105969.4AGER, SERPINF1
12cellular response to glucose stimulusGO:00713339.4AGER, ICAM1, SERPINF1
13cell adhesionGO:00071559.0ICAM1, SELE, VCAM1
14extracellular matrix organizationGO:00301988.9ICAM1, ITGAM, KDR, VCAM1

Sources for Leukostasis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet