Aliases & Classifications for Leukostasis

MalaCards integrated aliases for Leukostasis:

Name: Leukostasis 12 51 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:12986
MeSH 41 D018921
NCIt 46 C4062
SNOMED-CT 64 30419000
UMLS 69 C0282548

Summaries for Leukostasis

MalaCards based summary : Leukostasis is related to ischemia and granulocytopenia. An important gene associated with Leukostasis is ICAM1 (Intercellular Adhesion Molecule 1), and among its related pathways/superpathways are fMLP Pathway and Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways. Affiliated tissues include myeloid, endothelial and monocytes, and related phenotypes are cardiovascular system and cellular

Wikipedia : 72 Leukostasis (also called symptomatic hyperleukocytosis) is a medical emergency most commonly seen in... more...

Related Diseases for Leukostasis

Diseases related to Leukostasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 117)
# Related Disease Score Top Affiliating Genes
1 ischemia 30.2 ICAM1 MPO VEGFA
2 granulocytopenia 30.1 MPO SELL
3 microvascular complications of diabetes 5 29.8 ICAM1 KDR VCAM1 VEGFA
4 leukemia 10.5
5 cortical thymoma 10.4 ICAM1 VCAM1
6 limbal stem cell deficiency 10.4 ICAM1 VCAM1
7 rapidly progressive glomerulonephritis 10.4 ICAM1 MPO
8 acute proliferative glomerulonephritis 10.4 ICAM1 MPO
9 arteriosclerosis obliterans 10.4 ICAM1 VCAM1
10 macular retinal edema 10.3 ICAM1 VEGFA
11 retinitis 10.3
12 pulmonary aspergilloma 10.3 MPO VEGFA
13 heterophyiasis 10.3 ICAM1 SELE
14 hymenolepiasis 10.3 ICAM1 SELE
15 diabetic macular edema 10.3 ICAM1 VEGFA
16 dengue disease 10.3 ICAM1 VCAM1
17 nodular goiter 10.3 ICAM1 VEGFA
18 hydrops, lactic acidosis, and sideroblastic anemia 10.3 MPO VEGFA
19 angiokeratoma circumscriptum 10.2 KDR VEGFA
20 skin hemangioma 10.2 KDR VEGFA
21 capillary hemangioma 10.2 KDR VEGFA
22 radiation proctitis 10.2 KDR VEGFA
23 epithelioid hemangioendothelioma 10.2 KDR VEGFA
24 kuhnt-junius degeneration 10.2 KDR VEGFA
25 plasmodium vivax malaria 10.2 ICAM1 SELE
26 acute hemorrhagic leukoencephalitis 10.2 KDR VEGFA
27 critical illness polyneuropathy 10.2 ICAM1 SELE
28 angiomatous meningioma 10.2 KDR VEGFA
29 coats disease 10.2 KDR VEGFA
30 immune-complex glomerulonephritis 10.2 ICAM1 MPO VCAM1
31 polyarteritis nodosa 10.2 MPO SELE
32 henoch-schoenlein purpura 10.2 ICAM1 MPO VCAM1
33 oral lichen planus 10.2 ICAM1 VCAM1
34 myeloid leukemia 10.2
35 crescentic glomerulonephritis 10.2 ICAM1 MPO VCAM1
36 proctitis 10.2 KDR MPO
37 lymphangioma 10.2 KDR VEGFA
38 peripheral artery disease 10.2 VCAM1 VEGFA
39 glomerulonephritis 10.2 ICAM1 MPO VCAM1
40 allergic rhinitis 10.1 ICAM1 MPO VCAM1
41 microvascular complications of diabetes 1 10.1 ICAM1 VCAM1 VEGFA
42 primary progressive multiple sclerosis 10.1 ICAM1 VCAM1
43 cutaneous lupus erythematosus 10.1 ICAM1 SELE
44 vascular cancer 10.1 KDR VEGFA
45 leukemia, acute myeloid 10.1
46 toxicodendron dermatitis 10.1 ICAM1 SELL
47 lymphocytic vasculitis 10.1 ICAM1 SELE VCAM1
48 mooren's ulcer 10.1 ICAM1 SELE VCAM1
49 subendocardial myocardial infarction 10.1 ICAM1 SELE VCAM1
50 actinic prurigo 10.1 ICAM1 SELE VCAM1

Graphical network of the top 20 diseases related to Leukostasis:



Diseases related to Leukostasis

Symptoms & Phenotypes for Leukostasis

MGI Mouse Phenotypes related to Leukostasis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.01 SELE ICAM1 SELL KDR VCAM1 MPO
2 cellular MP:0005384 9.97 NFATC4 SELE ICAM1 SELL KDR VCAM1
3 growth/size/body region MP:0005378 9.92 NFATC4 SELE ICAM1 SELL KDR VCAM1
4 hematopoietic system MP:0005397 9.91 SELE ICAM1 SELL KDR VCAM1 MPO
5 immune system MP:0005387 9.76 SELE ICAM1 SELL KDR VCAM1 MPO
6 muscle MP:0005369 9.43 NFATC4 ICAM1 KDR MPO NFATC2 VEGFA
7 respiratory system MP:0005388 9.02 SELE SELL KDR NFATC2 VEGFA

Drugs & Therapeutics for Leukostasis

Search Clinical Trials , NIH Clinical Center for Leukostasis

Cochrane evidence based reviews: leukostasis

Genetic Tests for Leukostasis

Anatomical Context for Leukostasis

MalaCards organs/tissues related to Leukostasis:

38
Myeloid, Endothelial, Monocytes, Neutrophil, Lung, Spleen, Brain

Publications for Leukostasis

Articles related to Leukostasis:

(show top 50) (show all 121)
# Title Authors Year
1
Pulmonary Leukostasis: Treatment When Cytoreduction Does Not Suffice. ( 28060107 )
2017
2
Leukostasis: Management to Prevent Crisis in Acute Leukemiaa8c. ( 29149122 )
2017
3
Is leukostasis a crucial step or epiphenomenon in the pathogenesis of diabetic retinopathy? ( 28724696 )
2017
4
Comparing leukapheresis protocols for an AML patient with symptomatic leukostasis. ( 28940295 )
2017
5
Curcumolide reduces diabetic retinal vascular leukostasis and leakage partly via inhibition of the p38MAPK/NF-I_ B signaling. ( 28274631 )
2017
6
Targeting of 12/15-Lipoxygenase in retinal endothelial cells, but not in monocytes/macrophages, attenuates high glucose-induced retinal leukostasis. ( 28351645 )
2017
7
Leukostasis in adult acute hyperleukocytic leukemia: a clinician's digest. ( 27018197 )
2016
8
High Output Cardiac Failure in a Patient Presenting with Acute Myeloid Leukemia and Leukostasis. ( 29193920 )
2016
9
Exchange Transfusion and Leukapheresis in Pediatric Patients with AML With High Risk of Early Death by Bleeding and Leukostasis. ( 26670831 )
2016
10
miR-15a/16 reduces retinal leukostasis through decreased pro-inflammatory signaling. ( 27931222 )
2016
11
Hyperleukocytosis and leukostasis: management of a medical emergency. ( 27967252 )
2016
12
Pulmonary leukostasis with severe respiratory impairment as a debut of acute myeloid leukemia. ( 26157660 )
2015
13
Leukostasis Retinopathy: A New Clinical Manifestation of Chronic Myeloid Leukemia With Severe Hyperleukocytosis. ( 26247460 )
2015
14
Leukostasis in Children and Adolescents with Chronic Myeloid Leukemia: Japanese Pediatric Leukemia/Lymphoma Study Group. ( 26485422 )
2015
15
NFAT isoforms play distinct roles in TNFI+-induced retinal leukostasis. ( 26527057 )
2015
16
How we approach a patient with symptoms of leukostasis requiring emergent leukocytapheresis. ( 26267387 )
2015
17
Pathologic rupture of the spleen in a patient with acute myelogenous leukemia and leukostasis. ( 25031169 )
2014
18
Transfusion medicine illustrated. Catastrophic basilar artery leukostasis in the setting of acute myeloid leukemia. ( 24724788 )
2014
19
The effect of puerarin against IL-1I^-mediated leukostasis and apoptosis in retinal capillary endothelial cells (TR-iBRB2). ( 25593509 )
2014
20
Leukostasis in an Adult with AML Presenting as Multiple High Attenuation Brain Masses on CT. ( 24551717 )
2013
21
Genetic mutations in patients with acute myeloid leukemia and leukostasis. ( 23548579 )
2013
22
Hyperleukocytosis, leukostasis and leukapheresis: practice management. ( 22364832 )
2012
23
CD11b+ bone marrow-derived monocytes are the major leukocyte subset responsible for retinal capillary leukostasis in experimental diabetes in mouse and express high levels of CCR5 in the circulation. ( 22677420 )
2012
24
Intra-ophthalmic artery chemotherapy triggers vascular toxicity through endothelial cell inflammation and leukostasis. ( 22427570 )
2012
25
Therapeutic leukapheresis in patients with leukostasis secondary to acute myelogenous leukemia. ( 21574176 )
2011
26
TNFalpha is required for late BRB breakdown in diabetic retinopathy, and its inhibition prevents leukostasis and protects vessels and neurons from apoptosis. ( 21212173 )
2011
27
Rapid treatment of leukostasis in leukemic mantle cell lymphoma using therapeutic leukapheresis: a case report. ( 22224069 )
2011
28
Reversal of leukostasis-related pulmonary distress syndrome after leukapheresis and low-dose chemotherapy in acute myeloid leukemia. ( 21825265 )
2011
29
Pazopanib, a multitargeted tyrosine kinase inhibitor, reduces diabetic retinal vascular leukostasis and leakage. ( 21945644 )
2011
30
Pulmonary leukostasis mimicking tuberculosis in endemic area. ( 20004472 )
2010
31
Phosphomannopentaose sulfate (PI-88) inhibits retinal leukostasis in diabetic rat. ( 19250642 )
2009
32
Targeting leukostasis for the treatment of early diabetic retinopathy. ( 19619127 )
2009
33
Reliability of leukostasis grading score to identify patients with high-risk hyperleukocytosis. ( 19391131 )
2009
34
Inhibition of diabetic leukostasis and blood-retinal barrier breakdown with a soluble form of a receptor for advanced glycation end products. ( 17251488 )
2007
35
A case report of therapeutic leukapheresis in an adult with chronic myelogenous leukemia presenting with hyperleukocytosis and leukostasis. ( 17381536 )
2007
36
TNF-alpha is critical for ischemia-induced leukostasis, but not retinal neovascularization nor VEGF-induced leakage. ( 17107717 )
2007
37
Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood-retinal barrier breakdown in diabetic retinopathy. ( 17962481 )
2007
38
Leukostasis and pigment epithelium-derived factor in rat models of diabetic retinopathy. ( 17653050 )
2007
39
Images in clinical medicine. FLT3 Mutation and acute myelogenous leukemia with leukostasis. ( 17942876 )
2007
40
Role of NADPH oxidase and ANG II in diabetes-induced retinal leukostasis. ( 17652361 )
2007
41
Pigment epithelium-derived factor (PEDF) prevents diabetes- or advanced glycation end products (AGE)-elicited retinal leukostasis. ( 16797605 )
2006
42
Hyperleukocytosis associated pulmonary leukostasis in acute leukaemia. ( 16909741 )
2006
43
Correlation between expression of CD56/NCAM and severe leukostasis in hyperleukocytic acute myelomonocytic leukaemia. ( 16519701 )
2006
44
Role of angiotensin II in retinal leukostasis in the diabetic rat. ( 16822509 )
2006
45
Intravitreal injection of corticosteroid attenuates leukostasis and vascular leakage in experimental diabetic retina. ( 15790913 )
2005
46
Grading of symptoms in hyperleukocytic leukaemia: a clinical model for the role of different blast types and promyelocytes in the development of leukostasis syndrome. ( 15876254 )
2005
47
Management of life-threatening pulmonary leukostasis with single agent imatinib mesylate during CML myeloid blast crisis. ( 15377482 )
2004
48
Case report: mantle cell lymphoma, prolymphocytoid variant, with leukostasis syndrome. ( 15197401 )
2004
49
The role of advanced glycation end products in retinal microvascular leukostasis. ( 14507893 )
2003
50
Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes: role of oxidants and protein kinase-C activation. ( 12606527 )
2003

Variations for Leukostasis

Expression for Leukostasis

Search GEO for disease gene expression data for Leukostasis.

Pathways for Leukostasis

Pathways related to Leukostasis according to GeneCards Suite gene sharing:

(show all 34)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.77 KDR NFATC2 NFATC4 VEGFA
2
Show member pathways
12.45 ICAM1 KDR VCAM1 VEGFA
3
Show member pathways
12.38 KDR NFATC2 NFATC4 VEGFA
4
Show member pathways
12.36 ICAM1 NFATC2 NFATC4 VEGFA
5 12.34 MPO NFATC2 NFATC4 VCAM1
6 12.22 ICAM1 NFATC2 NFATC4 VCAM1
7
Show member pathways
12.13 ICAM1 NFATC2 NFATC4 VCAM1
8
Show member pathways
12.06 NFATC2 NFATC4 VEGFA
9
Show member pathways
11.96 ICAM1 KDR VCAM1
10
Show member pathways
11.94 ICAM1 KDR SELE VCAM1 VEGFA
11 11.9 ICAM1 SELL VCAM1
12 11.88 KDR VCAM1 VEGFA
13 11.83 ICAM1 SELE SELL VCAM1
14 11.81 ICAM1 VCAM1 VEGFA
15 11.77 ICAM1 SELE VCAM1
16 11.62 ICAM1 SELE VCAM1 VEGFA
17 11.36 ICAM1 SELE VCAM1
18 11.32 KDR VEGFA
19 11.32 NFATC2 NFATC4 VEGFA
20 11.3 ICAM1 VCAM1
21 11.3 NFATC2 NFATC4
22 11.29 ICAM1 SELE VCAM1
23
Show member pathways
11.27 KDR VEGFA
24 11.27 KDR VEGFA
25 11.23 SELE SELL
26 11.21 NFATC2 NFATC4
27 11.16 KDR VEGFA
28 11.16 ICAM1 KDR SELE VCAM1 VEGFA
29 11.12 ICAM1 SELE VCAM1
30
Show member pathways
11.06 ICAM1 SELE VCAM1 VEGFA
31 11 KDR VEGFA
32 10.84 VCAM1 VEGFA
33
Show member pathways
10.8 KDR VEGFA
34 10.64 ICAM1 MPO VCAM1

GO Terms for Leukostasis

Cellular components related to Leukostasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.33 ICAM1 SELL VCAM1
2 membrane raft GO:0045121 9.13 ICAM1 KDR SELE
3 cell surface GO:0009986 8.92 ICAM1 SELL VCAM1 VEGFA

Biological processes related to Leukostasis according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.87 ICAM1 SELE SELL VCAM1
2 leukocyte migration GO:0050900 9.77 ICAM1 SELE SELL
3 extracellular matrix organization GO:0030198 9.75 ICAM1 KDR VCAM1
4 regulation of immune response GO:0050776 9.73 ICAM1 SELL VCAM1
5 response to hypoxia GO:0001666 9.7 ICAM1 VCAM1 VEGFA
6 regulation of cell shape GO:0008360 9.67 ICAM1 KDR VEGFA
7 ovarian follicle development GO:0001541 9.61 ICAM1 VEGFA
8 positive regulation of blood vessel endothelial cell migration GO:0043536 9.61 KDR VEGFA
9 negative regulation of endothelial cell apoptotic process GO:2000352 9.6 ICAM1 KDR
10 branching involved in blood vessel morphogenesis GO:0001569 9.58 NFATC4 VEGFA
11 response to lipopolysaccharide GO:0032496 9.56 ICAM1 MPO SELE VCAM1
12 positive regulation of focal adhesion assembly GO:0051894 9.55 KDR VEGFA
13 positive regulation of receptor internalization GO:0002092 9.54 SELE VEGFA
14 calcium-mediated signaling using intracellular calcium source GO:0035584 9.51 KDR VCAM1
15 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.5 ICAM1 SELE VCAM1
16 cell migration involved in sprouting angiogenesis GO:0002042 9.48 KDR VEGFA
17 positive regulation of positive chemotaxis GO:0050927 9.46 KDR VEGFA
18 calcineurin-NFAT signaling cascade GO:0033173 9.43 NFATC2 NFATC4
19 membrane to membrane docking GO:0022614 9.4 ICAM1 VCAM1
20 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.37 KDR VEGFA
21 leukocyte cell-cell adhesion GO:0007159 9.33 ICAM1 SELE VCAM1
22 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.13 KDR VCAM1 VEGFA
23 leukocyte tethering or rolling GO:0050901 8.8 SELE SELL VCAM1

Molecular functions related to Leukostasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 9.33 MPO SELL VEGFA
2 integrin binding GO:0005178 9.13 ICAM1 KDR VCAM1
3 oligosaccharide binding GO:0070492 8.62 SELE SELL

Sources for Leukostasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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