MCID: LKS001
MIFTS: 49

Leukostasis malady

Blood diseases category
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Summaries for Leukostasis

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65Wikipedia, 33MalaCards
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Wikipedia:65 Leukostasis (aka symptomatic hyperleukocytosis) is a white blood cell count above 100,000/?L. It is... more...

MalaCards: Leukostasis is related to leukemia and respiratory failure. An important gene associated with Leukostasis is SELE (selectin E), and among its related pathways are Immune response Role of integrins in NK cells cytotoxicity and Staphylococcus aureus infection. The compounds 8 methoxypsoralen and sele have been mentioned in the context of this disorder. Affiliated tissues include lung, brain and myeloid, and related mouse phenotypes are no phenotypic analysis and vision/eye.

Aliases & Classifications for Leukostasis

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 40NCIt, 35MeSH, 58SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood diseases


Aliases & Descriptions:

leukostasis 8 10 45 62


External Ids:

Disease Ontology8 DOID:12986
NCIt40 C4062
SNOMED-CT58 30419000
MeSH35 D018921

Related Diseases for Leukostasis

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17GeneCards, 18GeneDecks
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Diseases related to Leukostasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 119)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia30.8TNF, MPO, SERPINF1, KDR, ICAM1, C5AR1
2respiratory failure30.3ICAM1, TNF
3ischemia30.3C5AR1, ICAM1, KDR, SELE, MPO
4diabetic retinopathy30.3SERPINF1, KDR, VCAM1, ICAM1, AGER
5leukopenia30.2C5AR1, MPO
6pneumonia30.1TNF, MPO, ICAM1, C5AR1
7monocytic leukemia30.0TNF, VCAM1
8hypertension30.0SELE, VCAM1, ICAM1
9insulin resistance29.9TNF, SELE, VCAM1, AGER
10retinitis10.5
11granulocytopenia10.3
12myeloid leukemia10.2
13acute myeloid leukemia10.2
14hepatitis10.2
15endotheliitis10.2
16skin disease10.1MPO
17diabetic macular edema10.1SERPINF1
18acute leukemia10.1
19cerebritis10.1
20mantle cell lymphoma10.1
21acute promyelocytic leukemia10.1
22goodpasture syndrome10.1VCAM1, MPO
23peripheral vascular disease10.1MPO, SELE
24plummer's disease10.1ICAM1, SELE
25rapidly progressive glomerulonephritis10.1MPO, ICAM1
26rhinitis10.1VCAM1, ICAM1
27allergic contact dermatitis10.1SELE, ICAM1
28arteriosclerosis obliterans10.1ICAM1, VCAM1
29inclusion body myositis10.1ICAM1, VCAM1
30allergic rhinitis10.1MPO, ICAM1
31wegener's granulomatosis10.1MPO, SELE
32antiphospholipid syndrome10.1SELE, VCAM1
33oral lichen planus10.1VCAM1, ICAM1
34plasmodium falciparum malaria10.1ICAM1, SELE
35diabetic angiopathy10.1AGER, SELE
36vernal keratoconjunctivitis10.1ICAM1, VCAM1
37adult respiratory distress syndrome10.1SELE, TNF
38arteriosclerosis10.1ICAM1, VCAM1
39psoriatic arthritis10.1SELE, TNF
40sickle cell disease10.1SELE, VCAM1
41hyperhomocysteinemia10.1VCAM1, SELE
42behcet's disease10.0SELE, TNF
43alcoholic hepatitis10.0ICAM1, TNF
44rheumatoid vasculitis10.0SELE, VCAM1, ICAM1
45pulmonary sarcoidosis10.0TNF, ICAM1
46immunoglobulin a vasculitis10.0ICAM1, VCAM1, MPO
47polymyositis10.0SELE, VCAM1, ICAM1
48dermatomyositis10.0ICAM1, VCAM1
49stroke, ischemic10.0SELE, VCAM1, ICAM1
50dermatitis10.0SELE, VCAM1, ICAM1

Graphical network of the top 20 diseases related to Leukostasis:



Diseases related to leukostasis

Symptoms for Leukostasis

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Drugs & Therapeutics for Leukostasis

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

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Genetic Tests for Leukostasis

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Anatomical Context for Leukostasis

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33MalaCards
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MalaCards organs/tissues related to Leukostasis:

33
Lung, Brain, Myeloid, Endothelial, Monocytes, Bone, Retina

Animal Models for Leukostasis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Leukostasis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.1AGER, VCAM1, KDR, TNF
2MP:00053917.9TNF, SERPINF1, SELE, KDR, ICAM1
3MP:00053697.8AGER, ICAM1, KDR, MPO, TNF
4MP:00107717.7TNF, SELE, KDR, ICAM1, AGER
5MP:00107687.2TNF, MPO, SELE, KDR, VCAM1, ICAM1
6MP:00053787.1TNF, SELE, KDR, VCAM1, ICAM1, AGER
7MP:00053856.8AGER, TNF, MPO, SERPINF1, SELE, KDR
8MP:00053976.7TNF, MPO, SELE, KDR, VCAM1, ICAM1
9MP:00053876.7TNF, MPO, SELE, KDR, VCAM1, ICAM1
10MP:00053766.7TNF, MPO, SELE, KDR, VCAM1, ICAM1

Publications for Leukostasis

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52PubMed
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Articles related to Leukostasis:

(show top 50)    (show all 101)
idTitleAuthorsYear
1
Genetic mutations in patients with acute myeloid leukemia and leukostasis. (23548579)
2013
2
CD11b+ bone marrow-derived monocytes are the major leukocyte subset responsible for retinal capillary leukostasis in experimental diabetes in mouse and express high levels of CCR5 in the circulation. (22677420)
2012
3
Hyperleukocytosis, leukostasis and leukapheresis: practice management. (22364832)
2012
4
Reversal of leukostasis-related pulmonary distress syndrome after leukapheresis and low-dose chemotherapy in acute myeloid leukemia. (21825265)
2011
5
Rapid treatment of leukostasis in leukemic mantle cell lymphoma using therapeutic leukapheresis: a case report. (22224069)
2011
6
Phosphomannopentaose sulfate (PI-88) inhibits retinal leukostasis in diabetic rat. (19250642)
2009
7
Targeting leukostasis for the treatment of early diabetic retinopathy. (19619127)
2009
8
Reliability of leukostasis grading score to identify patients with high-risk hyperleukocytosis. (19391131)
2009
9
Leukostasis and pigment epithelium-derived factor in rat models of diabetic retinopathy. (17653050)
2007
10
Role of NADPH oxidase and ANG II in diabetes-induced retinal leukostasis. (17652361)
2007
11
Inhibition of diabetic leukostasis and blood-retinal barrier breakdown with a soluble form of a receptor for advanced glycation end products. (17251488)
2007
12
Correlation between expression of CD56/NCAM and severe leukostasis in hyperleukocytic acute myelomonocytic leukaemia. (16519701)
2006
13
Intravitreal injection of corticosteroid attenuates leukostasis and vascular leakage in experimental diabetic retina. (15790913)
2005
14
Case report: mantle cell lymphoma, prolymphocytoid variant, with leukostasis syndrome. (15197401)
2004
15
Management of life-threatening pulmonary leukostasis with single agent imatinib mesylate during CML myeloid blast crisis. (15377482)
2004
16
The role of advanced glycation end products in retinal microvascular leukostasis. (14507893)
2003
17
Pulmonary leukostasis and the inhibition of airway neutrophil recruitment are early events in the endotoxemic rat. (11837792)
2002
18
Effective and selective prevention of retinal leukostasis in streptozotocin-induced diabetic rats using gliclazide. (12107755)
2002
19
Leukapheresis in chronic myelomonocytic leukemia with leukostasis syndrome: elevated serum lactate levels as an early sign of microcirculation failure. (12389624)
2002
20
Endothelial cell activation by myeloblasts: molecular mechanisms of leukostasis and leukemic cell dissemination. (11264180)
2001
21
Integrin-mediated neutrophil adhesion and retinal leukostasis in diabetes. (10752954)
2000
22
Pulmonary leukostasis mimicking pulmonary embolism. (10654454)
2000
23
Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition. (10485912)
1999
24
Use of genetically manipulated strains of Clostridium perfringens reveals that both alpha-toxin and theta-toxin are required for vascular leukostasis to occur in experimental gas gangrene. (10456947)
1999
25
Pressure-related capillary leukostasis following ischemia-reperfusion and hemorrhagic shock. (8342655)
1993
26
Involvement of the complement system in the pathogenesis of pulmonary leukostasis in experimental myelocytic leukemia. (8412322)
1993
27
Treatment of acute promyelocytic leukemia with all-trans retinoic acid: successful control of hyperleukocytosis and leukostasis syndrome with leukaphereses and hydroxyurea. (8372818)
1993
28
Acute leukostasis pulmonary distress syndrome. (1402733)
1992
29
Pulmonary leukostasis secondary to all-trans retinoic acid in the treatment of acute promyelocytic leukemia in first relapse. (1602800)
1992
30
Pulmonary leukostasis without hyperleukocytosis: a clinicopathologic study of 16 cases. (1566743)
1992
31
Development of pulmonary leukostasis in experimental myelocytic leukemia in the Brown-Norway rat. (1552745)
1992
32
The state of leucocyte adhesiveness/aggregation (LAA) in the peripheral blood of burned mice: an early and sensitive inflammatory indicator and a marker of pulmonary leukostasis. (1793493)
1991
33
An unusual case of hairy cell leukemia: death due to leukostasis and intracerebral hemorrhage. (1748438)
1991
34
Effects of cardiopulmonary bypass on pulmonary leukostasis and complement activation. (3190431)
1988
35
Interleukin-1-induced granulocytopenia and pulmonary leukostasis in rabbits. (3031000)
1987
36
Quantitative estimation of leukostasis in the posttraumatic lung--canine and human autopsy data. (3615443)
1987
37
Pulmonary leukostasis in a patient with chronic myeloid leukemia. (3475250)
1986
38
Aleukaemic leukostasis in a case of large cell non-Hodgkin's lymphoma: report of a case with a distinctive central nervous system involvement. (3760899)
1986
39
Streptococcus pneumoniae-induced alterations in levels of circulating thromboxane and prostacyclin: dissociation from granulocytopenia, thrombocytopenia, and pulmonary leukostasis. (3510262)
1986
40
Amphotericin B causes aggregation of neutrophils and enhances pulmonary leukostasis. (4037532)
1985
41
Intravascular leukostasis in a horse with myelomonocytic leukemia. (6592873)
1984
42
Reversal of hemodialysis granulocytopenia and pulmonary leukostasis: A clinical manifestation of selective down-regulation of granulocyte responses to C5adesarg. (7229031)
1981
43
Pneumococcus-induced granulocytopenia and pulmonary leukostasis in rabbits. (7452094)
1981
44
Complement-induced vascular leukostasis. Its role in tissue injury. (6893656)
1980
45
Pulmonary leukostasis and its relationship to pulmonary dysfunction in sheep and rabbits. (7351034)
1980
46
Leukostasis in SAczary syndrome. (439311)
1979
47
Rapid cytoreduction in acute leukemia. Management of cerebral leukostasis by cell pheresis. (272799)
1978
48
Hydroxyurea in the prevention of the effects of leukostasis in acute leukemia. (268956)
1977
49
Hemodialysis leukopenia. Pulmonary vascular leukostasis resulting from complement activation by dialyzer cellophane membranes. (856872)
1977
50
The pathologic characteristics of leukostasis and leukemic nodules occurring in the central nervous system of guinea pigs with L2C/NB leukemia. (1245856)
1976

Variations for Leukostasis

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Expression for genes affiliated with Leukostasis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Leukostasis

Search GEO for disease gene expression data for Leukostasis.

Pathways for genes affiliated with Leukostasis

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50PathCards, 60Thomson Reuters, 30KEGG, 38NCBI BioSystems Database, 55Reactome, 53QIAGEN
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Compounds for genes affiliated with Leukostasis

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45Novoseek, 51PharmGKB, 11DrugBank, 61Tocris Bioscience, 24HMDB, 29IUPHAR, 3BitterDB
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Compounds related to Leukostasis according to GeneCards/GeneDecks:

(show top 50)    (show all 146)
idCompoundScoreTop Affiliating Genes
18 methoxypsoralen459.7VCAM1, ICAM1, SELE
2sele459.6SELE, ICAM1, VCAM1
3gliclazide45 51 1111.5ICAM1, VCAM1, SELE, MPO
4mycophenolic acid45 51 1111.4VCAM1, ICAM1, SELE
5ro 31-7549459.3SELE, TNF, VCAM1
6celastrol45 6110.3TNF, VCAM1, SELE
7hcec459.2KDR, VCAM1, ICAM1
8ulinastatin459.2ICAM1, MPO, TNF
9slex459.1VCAM1, SELE, ICAM1
10fluticasone propionate45 51 61 1112.0VCAM1, TNF, MPO, SELE
11nadph45 2410.0VCAM1, SERPINF1, MPO, AGER
12sulfasalazine29 45 51 1112.0MPO, TNF, SELE, ICAM1
13polymyxin b459.0TNF, VCAM1, SELE, ICAM1
14okt3459.0TNF, VCAM1, SELE, ICAM1
15groalpha459.0TNF, SELE, VCAM1, ICAM1
16budesonide45 51 1110.9ICAM1, VCAM1, MPO, TNF
17fenofibrate45 51 1110.9SELE, VCAM1, ICAM1, TNF
18pdtc458.9VCAM1, SELE, ICAM1, TNF
19pentoxifylline45 119.9TNF, MPO, VCAM1, ICAM1
20atorvastatin45 51 29 24 1112.8TNF, SELE, VCAM1, ICAM1
21n-formylmethionyl-leucylphenylalanine458.7C5AR1, TNF, ICAM1, MPO
22cyclophosphamide45 51 1110.7SELE, KDR, VCAM1, MPO
23troglitazone45 29 61 1111.7VCAM1, SELE, ICAM1, TNF
24prednisolone45 29 1110.7MPO, VCAM1, C5AR1, TNF
25apocynin45 619.6TNF, MPO, ICAM1, VCAM1, SELE
268-isoprostane458.6ICAM1, VCAM1, SELE, MPO, TNF
27matrigel458.6ICAM1, SELE, SERPINF1, VCAM1, KDR
28herbimycin a45 619.6VCAM1, SELE, ICAM1, TNF
29diphenyleneiodonium458.5VCAM1, ICAM1, MPO, TNF, SERPINF1
30endotoxin458.4SELE, TNF, VCAM1, C5AR1, ICAM1
31fmlp458.4C5AR1, MPO, VCAM1, ICAM1, TNF
32rantes458.4TNF, C5AR1, SELE, VCAM1, ICAM1
33sb 20358045 619.4C5AR1, ICAM1, TNF, SELE, VCAM1
34simvastatin45 51 61 29 24 1113.3VCAM1, KDR, SELE, ICAM1, TNF
35fibrinogen458.3ICAM1, VCAM1, C5AR1, TNF, SELE
36ly294002458.2TNF, SELE, KDR, VCAM1, ICAM1
37genistein45 29 61 3 24 1113.2ICAM1, TNF, SELE, KDR, VCAM1
38histamine45 29 2410.1SELE, TNF, ICAM1, C5AR1, VCAM1, MPO
39pge2458.1C5AR1, ICAM1, VCAM1, SELE, TNF, MPO
40lactate458.0TNF, MPO, VCAM1, SELE, ICAM1, KDR
41superoxide45 249.0AGER, TNF, MPO, VCAM1, C5AR1
42heparin45 29 24 1110.7AGER, VCAM1, KDR, SELE, SERPINF1, MPO
43h2o2457.7MPO, C5AR1, KDR, SERPINF1, ICAM1, TNF
44retinoic acid45 248.6KDR, TNF, MPO, VCAM1, ICAM1, SERPINF1
45oxygen45 248.4TNF, ICAM1, MPO, SERPINF1, VCAM1, C5AR1
46prostacyclin457.3KDR, VCAM1, ICAM1, SELE, C5AR1, TNF
47n acetylcysteine457.1ICAM1, SELE, SERPINF1, MPO, TNF, VCAM1
48serine456.9SERPINF1, MPO, SELE, KDR, VCAM1, C5AR1
49vegf456.5SERPINF1, SELE, MPO, KDR, TNF, VCAM1
50nitric oxide45 24 118.5SELE, MPO, AGER, ICAM1, SERPINF1, KDR

GO Terms for genes affiliated with Leukostasis

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16Gene Ontology
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Cellular components related to Leukostasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099868.8C5AR1, VCAM1, TNF
2membrane raftGO:0451218.4KDR, SELE, TNF
3external side of plasma membraneGO:0098978.3TNF, KDR, VCAM1, ICAM1
4extracellular spaceGO:0056157.9ICAM1, VCAM1, SELE, SERPINF1, MPO, TNF
5integral component of plasma membraneGO:0058877.5TNF, KDR, ICAM1, C5AR1, AGER
6plasma membraneGO:0058866.9TNF, SELE, KDR, VCAM1, ICAM1, C5AR1

Biological processes related to Leukostasis according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1membrane to membrane dockingGO:02261410.0VCAM1, ICAM1
2cellular response to glucose stimulusGO:0713339.9ICAM1, VCAM1
3response to ionizing radiationGO:0102129.8ICAM1, VCAM1
4cellular response to vascular endothelial growth factor stimulusGO:0359249.7KDR, VCAM1
5leukocyte cell-cell adhesionGO:0071599.7SELE, VCAM1, ICAM1
6heterophilic cell-cell adhesionGO:0071579.7ICAM1, VCAM1, SELE
7interferon-gamma-mediated signaling pathwayGO:0603339.7ICAM1, VCAM1
8cellular response to tumor necrosis factorGO:0713569.6ICAM1, VCAM1
9ovarian follicle developmentGO:0015419.6KDR, ICAM1
10agingGO:0075689.6MPO, SERPINF1, VCAM1
11negative regulation of growth of symbiont in hostGO:0441309.6MPO, TNF
12positive regulation of nitric oxide biosynthetic processGO:0454299.5ICAM1, TNF
13calcium-mediated signalingGO:0197229.4SELE, TNF
14defense response to Gram-positive bacteriumGO:0508309.3C5AR1, TNF
15activation of phospholipase C activityGO:0072029.3C5AR1, SELE
16response to mechanical stimulusGO:0096129.3TNF, MPO
17leukocyte tethering or rollingGO:0509019.3VCAM1, SELE, TNF
18response to lipopolysaccharideGO:0324969.3C5AR1, VCAM1, SELE, MPO
19positive regulation of NF-kappaB transcription factor activityGO:0510929.0AGER, ICAM1, TNF
20positive regulation of ERK1 and ERK2 cascadeGO:0703748.8C5AR1, KDR, TNF
21inflammatory responseGO:0069548.6TNF, SELE, C5AR1, AGER
22extracellular matrix organizationGO:0301988.6ICAM1, VCAM1, KDR, TNF

Molecular functions related to Leukostasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:0048889.2AGER, ICAM1, SELE
2integrin bindingGO:0051788.8ICAM1, VCAM1, KDR

Products for genes affiliated with Leukostasis

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Sources for Leukostasis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet