MCID: LKS001
MIFTS: 39

Leukostasis malady

Category: Blood diseases

Aliases & Classifications for Leukostasis

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Aliases & Descriptions for Leukostasis:

Name: Leukostasis 11 49 38 13 67

Classifications:



External Ids:

Disease Ontology11 DOID:12986
MeSH38 D018921
SNOMED-CT61 30419000
NCIt44 C4062

Summaries for Leukostasis

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Wikipedia:70 Leukostasis is an extreme form of leukocytosis (an excess of white blood cells) that is dangerously... more...

MalaCards based summary: Leukostasis is related to overnutrition and west nile fever, and has symptoms including cachexia, cancer pain and tumor pain. An important gene associated with Leukostasis is ICAM1 (Intercellular Adhesion Molecule 1), and among its related pathways are Immune response_MIF-mediated glucocorticoid regulation and Immune response_Role of integrins in NK cells cytotoxicity. Affiliated tissues include lung, brain and myeloid, and related mouse phenotypes are muscle and respiratory system.

Related Diseases for Leukostasis

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Diseases related to Leukostasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 102)
idRelated DiseaseScoreTop Affiliating Genes
1overnutrition10.5ICAM1, VCAM1
2west nile fever10.5ICAM1, VCAM1
3arteriolosclerosis10.5ICAM1, VCAM1
4liver disease10.4ICAM1, VCAM1
5hereditary renal cell carcinoma10.4ICAM1, VEGFA
6dentin dysplasia10.4ICAM1, VCAM1
7leukemia10.4
8parasitic helminthiasis infectious disease10.4ICAM1, SELE
9peripheral scars of retina10.4ICAM1, SELE
10speech disorder10.3ICAM1, VEGFA
11cysticercosis10.3ICAM1, SELE
12labyrinthine bilateral reactive loss10.2ICAM1, SELE
13intracranial primitive neuroectodermal tumor10.2ICAM1, MPO, VCAM1
14uveitis10.2ICAM1, MPO, VCAM1
15retinitis10.2
16bladder urachal carcinoma10.2KDR, VEGFA
17silicosiderosis10.2KDR, VEGFA
18malignant gastric germ cell tumor10.2KDR, VEGFA
19neuropathy, hereditary sensory and autonomic, type vi10.2ICAM1, VCAM1, VEGFA
20arthrogryposis, ectodermal dysplasia, cleft lip/palate, and developmental delay10.2KDR, VEGFA
21epidermolysis bullosa10.2KDR, VEGFA
22iliac vein thrombophlebitis10.2KDR, VEGFA
23calcaneonavicular coalition10.2KDR, VEGFA
24acute porphyria10.1KDR, MPO
25ocular melanoma10.1KDR, VEGFA
26gastric small cell carcinoma10.1KDR, VEGFA
27phagocyte bactericidal dysfunction10.1ICAM1, MPO, VEGFA
28hordeolum externum10.1VCAM1, VEGFA
29perivascular epithelioid cell tumor10.1KDR, VEGFA
30shwartzman phenomenon10.1ICAM1, SELL
31lymphomatoid papulosis10.1ICAM1, SELE, VCAM1
32marginal corneal ulcer10.1ICAM1, SELE, VCAM1
33rhizomelic pseudopolyarthritis10.1ICAM1, SELE, VCAM1
34posterolateral myocardial infarction10.1ICAM1, SELE, VCAM1
35spastic paraplegia-paget disease of bone syndrome10.1ICAM1, SELE, VCAM1
36lens disease10.1KDR, VEGFA
37dementia - subcortical10.1ICAM1, SELE, VCAM1
38chromoblastomycosis10.1ICAM1, MPO, SELE
39iron metabolism disease10.1ICAM1, SELE, VCAM1
40littre gland carcinoma10.1ICAM1, SELE, VCAM1
41angioedema10.1ICAM1, SELL
42myeloid leukemia10.1
43intraneural perineurioma10.0ICAM1, SELE, VEGFA
44epidural abscess10.0KDR, VEGFA
45developmental coordination disorder10.0ICAM1, SELE, VEGFA
46hyperinsulinism10.0KDR, VEGFA
47angina pectoris10.0SELE, VCAM1, VEGFA
48granulocytopenia10.0
49lipoatrophy with diabetes, leukomelanodermic papules, liver steatosis, and hypertrophic cardiomyopathy10.0KDR, VEGFA
50wissler's syndrome10.0ICAM1, SELE

Graphical network of the top 20 diseases related to Leukostasis:



Diseases related to leukostasis

Symptoms for Leukostasis

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UMLS symptoms related to Leukostasis:


cachexia, cancer pain, tumor pain, metastatic pain, psychomotor skills impaired, breakthrough pain

Drugs & Therapeutics for Leukostasis

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Leukostasis


Cochrane evidence based reviews: leukostasis

Genetic Tests for Leukostasis

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Anatomical Context for Leukostasis

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MalaCards organs/tissues related to Leukostasis:

35
Lung, Brain, Myeloid, Endothelial, Neutrophil, Monocytes, Bone

Animal Models for Leukostasis or affiliated genes

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MGI Mouse Phenotypes related to Leukostasis:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.5ICAM1, KDR, MPO, NFATC2, NFATC4, VEGFA
2MP:00053888.3KDR, NFATC2, SELE, SELL, VEGFA
3MP:00053918.1ICAM1, KDR, NFATC2, SELE, VEGFA
4MP:00053857.5ICAM1, KDR, MPO, NFATC4, SELE, SELL
5MP:00053877.3ICAM1, KDR, MPO, NFATC2, SELE, SELL
6MP:00053847.3ICAM1, KDR, NFATC2, NFATC4, SELE, SELL
7MP:00053787.3ICAM1, KDR, NFATC2, NFATC4, SELE, SELL
8MP:00053976.9ICAM1, KDR, MPO, NFATC2, NFATC4, SELE

Publications for Leukostasis

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Articles related to Leukostasis:

(show top 50)    (show all 115)
idTitleAuthorsYear
1
Pulmonary Leukostasis: Treatment When Cytoreduction Does Not Suffice. (28060107)
2017
2
miR-15a/16 reduces retinal leukostasis through decreased pro-inflammatory signaling. (27931222)
2016
3
Exchange Transfusion and Leukapheresis in Pediatric Patients with AML With High Risk of Early Death by Bleeding and Leukostasis. (26670831)
2016
4
Leukostasis Retinopathy: A New Clinical Manifestation of Chronic Myeloid Leukemia With Severe Hyperleukocytosis. (26247460)
2015
5
How we approach a patient with symptoms of leukostasis requiring emergent leukocytapheresis. (26267387)
2015
6
Transfusion medicine illustrated. Catastrophic basilar artery leukostasis in the setting of acute myeloid leukemia. (24724788)
2014
7
Genetic mutations in patients with acute myeloid leukemia and leukostasis. (23548579)
2013
8
Leukostasis in an Adult with AML Presenting as Multiple High Attenuation Brain Masses on CT. (24551717)
2013
9
Therapeutic leukapheresis in patients with leukostasis secondary to acute myelogenous leukemia. (21574176)
2011
10
Phosphomannopentaose sulfate (PI-88) inhibits retinal leukostasis in diabetic rat. (19250642)
2009
11
Inhibition of diabetic leukostasis and blood-retinal barrier breakdown with a soluble form of a receptor for advanced glycation end products. (17251488)
2007
12
Images in clinical medicine. FLT3 Mutation and acute myelogenous leukemia with leukostasis. (17942876)
2007
13
Hyperleukocytosis associated pulmonary leukostasis in acute leukaemia. (16909741)
2006
14
The role of advanced glycation end products in retinal microvascular leukostasis. (14507893)
2003
15
Pulmonary leukostasis and the inhibition of airway neutrophil recruitment are early events in the endotoxemic rat. (11837792)
2002
16
Effective and selective prevention of retinal leukostasis in streptozotocin-induced diabetic rats using gliclazide. (12107755)
2002
17
Leukapheresis in chronic myelomonocytic leukemia with leukostasis syndrome: elevated serum lactate levels as an early sign of microcirculation failure. (12389624)
2002
18
Cerebrovascular nodules in a patient with leukostasis. (12385403)
2002
19
The irreplaceable image: Cerebral leukostasis manifesting as multifocal intracerebral hemorrhage. (11694415)
2001
20
Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition. (10485912)
1999
21
T-lymphocytes contribute to hepatic leukostasis and hypoxic stress induced by gut ischemia-reperfusion. (10654278)
1999
22
Leukostasis followed by hemorrhage complicating the initiation of chemotherapy in patients with acute myeloid leukemia and hyperleukocytosis: a clinicopathologic report of four cases. (10023704)
1999
23
Central nervous system leukostasis in patients with leukemias and lymphomas. (8673423)
1995
24
Endotoxin-induced pulmonary leukostasis in the rat: role of platelet-activating factor and tumor necrosis factor. (8288963)
1994
25
Pressure-related capillary leukostasis following ischemia-reperfusion and hemorrhagic shock. (8342655)
1993
26
Involvement of the complement system in the pathogenesis of pulmonary leukostasis in experimental myelocytic leukemia. (8412322)
1993
27
Acute leukostasis pulmonary distress syndrome. (1402733)
1992
28
Development of pulmonary leukostasis in experimental myelocytic leukemia in the Brown-Norway rat. (1552745)
1992
29
The state of leucocyte adhesiveness/aggregation (LAA) in the peripheral blood of burned mice: an early and sensitive inflammatory indicator and a marker of pulmonary leukostasis. (1793493)
1991
30
An unusual case of hairy cell leukemia: death due to leukostasis and intracerebral hemorrhage. (1748438)
1991
31
Experimental myelocytic leukemia in the Brown-Norway rat as a model for pulmonary leukostasis. (2000946)
1991
32
Effects of cardiopulmonary bypass on pulmonary leukostasis and complement activation. (3190431)
1988
33
Interleukin-1-induced granulocytopenia and pulmonary leukostasis in rabbits. (3031000)
1987
34
High-voltage irradiation and hydroxyurea for pulmonary leukostasis in acute myelomonocytic leukemia. (3113160)
1987
35
Pulmonary leukostasis in a patient with chronic myeloid leukemia. (3475250)
1986
36
Streptococcus pneumoniae-induced alterations in levels of circulating thromboxane and prostacyclin: dissociation from granulocytopenia, thrombocytopenia, and pulmonary leukostasis. (3510262)
1986
37
Amphotericin B causes aggregation of neutrophils and enhances pulmonary leukostasis. (4037532)
1985
38
Distribution of pneumococcus-induced augmentation of tissue leukostasis in rabbits: specificity for the pulmonary vascular bed. (3973472)
1985
39
Pneumococcal sonicate-induced biphasic granulocytopenia and its dissociation from pulmonary leukostasis. The contribution of pneumococcal products and complement to early and late granulocytopenic phases. (6644159)
1983
40
Fatal complement-induced leukostasis after diatrizoate injection. Principles of clinicopathologic diagnosis. (6195360)
1983
41
Respiratory failure due to pulmonary leukostasis following chemotherapy of acute nonlymphocytic leukemia. (6831346)
1983
42
Gram-positive bacteria-induced granulocytopenia and pulmonary leukostasis in rabbits. (6286493)
1982
43
Reversal of hemodialysis granulocytopenia and pulmonary leukostasis: A clinical manifestation of selective down-regulation of granulocyte responses to C5adesarg. (7229031)
1981
44
Complement-induced vascular leukostasis. Its role in tissue injury. (6893656)
1980
45
Pulmonary leukostasis and its relationship to pulmonary dysfunction in sheep and rabbits. (7351034)
1980
46
Reversible respiratory failure due to intravascular leukostasis in chronic myelogenous leukemia. Relationship of oxygen transfer to leukocyte count. (291338)
1979
47
Rapid cytoreduction in acute leukemia. Management of cerebral leukostasis by cell pheresis. (272799)
1978
48
Leukostasis associated with blood transfusion in acute myeloid leukaemia. (273461)
1978
49
Hydroxyurea in the prevention of the effects of leukostasis in acute leukemia. (268956)
1977
50
Hemodialysis leukopenia. Pulmonary vascular leukostasis resulting from complement activation by dialyzer cellophane membranes. (856872)
1977

Variations for Leukostasis

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Expression for genes affiliated with Leukostasis

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Search GEO for disease gene expression data for Leukostasis.

Pathways for genes affiliated with Leukostasis

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Pathways related to Leukostasis according to GeneCards Suite gene sharing:

(show all 29)
idSuper pathwaysScoreTop Affiliating Genes
19.8ICAM1, VCAM1
29.8ICAM1, VCAM1
39.8ICAM1, MPO
49.5NFATC2, NFATC4
5
Show member pathways
9.5NFATC2, NFATC4
69.4KDR, VEGFA
7
Show member pathways
9.4KDR, VEGFA
8
Show member pathways
9.4KDR, VEGFA
99.4KDR, VEGFA
109.4KDR, VEGFA
119.4ICAM1, MPO, VCAM1
129.3ICAM1, SELE, VCAM1
139.3ICAM1, SELE, VCAM1
149.3ICAM1, SELE, VCAM1
159.3ICAM1, SELE, VCAM1
16
Show member pathways
9.2ICAM1, KDR, VCAM1
179.1SELE, SELL
189.1KDR, VCAM1, VEGFA
199.1NFATC2, NFATC4, VEGFA
209.0ICAM1, SELL, VCAM1
218.9ICAM1, SELE, VCAM1, VEGFA
228.8ICAM1, NFATC2, NFATC4, VCAM1
23
Show member pathways
8.8ICAM1, NFATC2, NFATC4, VCAM1
248.8MPO, NFATC2, NFATC4, VCAM1
25
Show member pathways
8.8ICAM1, KDR, VCAM1, VEGFA
26
Show member pathways
8.5KDR, NFATC2, NFATC4, VEGFA
27
Show member pathways
8.5KDR, NFATC2, NFATC4, VEGFA
288.5ICAM1, SELE, SELL, VCAM1
29
Show member pathways
8.3ICAM1, KDR, SELE, VCAM1, VEGFA

GO Terms for genes affiliated with Leukostasis

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Cellular components related to Leukostasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.2ICAM1, SELL, VCAM1
2membrane raftGO:00451218.9ICAM1, KDR, SELE
3extracellular spaceGO:00056158.5ICAM1, MPO, SELE, VCAM1, VEGFA
4cell surfaceGO:00099868.3ICAM1, SELL, VCAM1, VEGFA

Biological processes related to Leukostasis according to GeneCards Suite gene sharing:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1membrane to membrane dockingGO:002261410.4ICAM1, VCAM1
2leukocyte tethering or rollingGO:005090110.2SELE, VCAM1
3calcineurin-NFAT signaling cascadeGO:003317310.2NFATC2, NFATC4
4negative regulation of endothelial cell apoptotic processGO:200035210.1ICAM1, KDR
5positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathwayGO:003803310.1KDR, VEGFA
6cell migration involved in sprouting angiogenesisGO:000204210.1KDR, VEGFA
7positive regulation of endothelial cell migrationGO:001059510.0KDR, VEGFA
8positive regulation of positive chemotaxisGO:005092710.0KDR, VEGFA
9positive regulation of focal adhesion assemblyGO:005189410.0KDR, VEGFA
10leukocyte cell-cell adhesionGO:00071599.8ICAM1, SELE, VCAM1
11heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesGO:00071579.7ICAM1, SELE, VCAM1
12calcium-mediated signaling using intracellular calcium sourceGO:00355849.7KDR, VCAM1
13response to hypoxiaGO:00016669.4ICAM1, VCAM1, VEGFA
14regulation of immune responseGO:00507769.3ICAM1, SELL, VCAM1
15cellular response to vascular endothelial growth factor stimulusGO:00359249.3KDR, VCAM1, VEGFA
16regulation of cell shapeGO:00083609.3ICAM1, KDR, VEGFA
17extracellular matrix organizationGO:00301989.3ICAM1, KDR, VCAM1
18positive regulation of receptor internalizationGO:00020929.2SELE, VEGFA
19response to lipopolysaccharideGO:00324969.2ICAM1, MPO, SELE, VCAM1
20leukocyte migrationGO:00509008.9ICAM1, SELE, SELL

Molecular functions related to Leukostasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1integrin bindingGO:00051789.2ICAM1, KDR, VCAM1
2heparin bindingGO:00082018.8MPO, SELL, VEGFA

Sources for Leukostasis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet