MCID: LKS001
MIFTS: 35

Leukostasis malady

Category: Blood diseases

Aliases & Classifications for Leukostasis

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Aliases & Descriptions for Leukostasis:

Name: Leukostasis 11 50 39 13 68

Classifications:



External Ids:

Disease Ontology11 DOID:12986
MeSH39 D018921
SNOMED-CT62 30419000
NCIt45 C4062

Summaries for Leukostasis

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MalaCards based summary: Leukostasis is related to leukemia and subacute glomerulonephritis. An important gene associated with Leukostasis is ICAM1 (Intercellular Adhesion Molecule 1), and among its related pathways are Immune response_Role of integrins in NK cells cytotoxicity and Amplification and Expansion of Oncogenic Pathways as Metastatic Traits. Affiliated tissues include myeloid, endothelial and neutrophil, and related mouse phenotypes are muscle and respiratory system.

Related Diseases for Leukostasis

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Diseases related to Leukostasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 97)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia10.4
2subacute glomerulonephritis10.2ICAM1, MPO
3uveitis10.2ICAM1, MPO
4vaginal endometrial stromal tumor10.2ICAM1, VCAM1
5ovarian clear cell malignant adenofibroma10.2ICAM1, VCAM1
6tuberculous salpingitis10.2MPO, VEGFA
7retinitis10.2
8tonsil cancer10.2ICAM1, SELE
9lymphedema10.2ICAM1, VCAM1
10metal allergy10.2ICAM1, MPO
11sparganosis10.2ICAM1, SELE
12hirschsprung disease 710.2SELE, VCAM1
13lymph node disease10.2ICAM1, SELE
14kidney osteogenic sarcoma10.2KDR, VEGFA
15hand, foot and mouth disease10.2KDR, VEGFA
16cone-rod dystrophy 1710.2KDR, VEGFA
17vesiculobullous skin disease10.1KDR, VEGFA
18intracranial hypotension10.1KDR, VEGFA
19ependymoblastoma10.1ICAM1, MPO, VCAM1
20neuropathy with hearing impairment10.1KDR, VEGFA
21dislocation of ear ossicle10.1ICAM1, MPO, VCAM1
22benign idiopathic neonatal seizures10.1KDR, VEGFA
23multilocular clear cell renal cell carcinoma10.1ICAM1, VEGFA
24benign secondary hypertension10.1ICAM1, MPO, VCAM1
25biemond syndrome ii10.1KDR, VEGFA
26factitious disorder10.1KDR, VEGFA
27heart valve disease10.1ICAM1, MPO, VCAM1
28glucocorticoid resistance10.1ICAM1, MPO, VCAM1
29epidermolysis bullosa simplex, sutosomal recessive 210.1ICAM1, VCAM1, VEGFA
30ovarian disease10.1KDR, VEGFA
31hypopyon ulcer10.1ICAM1, SELE, VCAM1
32macrodactyly of the foot10.1ICAM1, SELE, VCAM1
33periosteal chondrosarcoma10.1ICAM1, SELE, VCAM1
34chromophobe adenoma10.1ICAM1, SELL
35right ventricle hypoplasia10.1ICAM1, SELE, VCAM1
36scalp dermatosis10.1KDR, MPO
37erb-duchenne and dejerine-klumpke palsies10.1ICAM1, SELE, VCAM1
38pyriform sinus cancer10.1ICAM1, VEGFA
39dermatomycosis10.1ICAM1, MPO, SELE
40pemphigus vulgaris, familial10.1ICAM1, SELE, VCAM1
41synovium cancer10.1ICAM1, SELE, VCAM1
42cervix small cell carcinoma10.1ICAM1, SELE, VCAM1
43myelophthisic anemia10.1ICAM1, SELE, VCAM1
44esotropia10.1MPO, SELE
45prostate disease10.1ICAM1, SELE, VEGFA
46myeloid leukemia10.1
47chromoblastomycosis10.0ICAM1, SELL
48vernal conjunctivitis10.0ICAM1, KDR, VEGFA
49congenital chloride diarrhea10.0SELE, VCAM1, VEGFA
50mental retardation, autosomal recessive 2710.0KDR, MPO, VEGFA

Graphical network of the top 20 diseases related to Leukostasis:



Diseases related to leukostasis

Symptoms & Phenotypes for Leukostasis

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MGI Mouse Phenotypes related to Leukostasis according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.5ICAM1, KDR, MPO, NFATC2, NFATC4, VEGFA
2MP:00053887.6KDR, NFATC2, SELE, SELL, VEGFA
3MP:00053857.5ICAM1, KDR, MPO, NFATC4, SELE, SELL
4MP:00053877.3ICAM1, KDR, MPO, NFATC2, SELE, SELL
5MP:00053847.3ICAM1, KDR, NFATC2, NFATC4, SELE, SELL
6MP:00053787.3ICAM1, KDR, NFATC2, NFATC4, SELE, SELL
7MP:00053976.9ICAM1, KDR, MPO, NFATC2, NFATC4, SELE

Drugs & Therapeutics for Leukostasis

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Leukostasis


Cochrane evidence based reviews: leukostasis

Genetic Tests for Leukostasis

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Anatomical Context for Leukostasis

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MalaCards organs/tissues related to Leukostasis:

36
Myeloid, Endothelial, Neutrophil, Lung, Monocytes, Spleen, Brain

Publications for Leukostasis

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Articles related to Leukostasis:

(show top 50)    (show all 115)
idTitleAuthorsYear
1
Pulmonary Leukostasis: Treatment When Cytoreduction Does Not Suffice. (28060107)
2017
2
Hyperleukocytosis and leukostasis: management of a medical emergency. (27967252)
2016
3
Leukostasis in adult acute hyperleukocytic leukemia: a clinician's digest. (27018197)
2016
4
Exchange Transfusion and Leukapheresis in Pediatric Patients with AML With High Risk of Early Death by Bleeding and Leukostasis. (26670831)
2016
5
miR-15a/16 reduces retinal leukostasis through decreased pro-inflammatory signaling. (27931222)
2016
6
Pulmonary leukostasis with severe respiratory impairment as a debut of acute myeloid leukemia. (26157660)
2015
7
NFAT isoforms play distinct roles in TNFI+-induced retinal leukostasis. (26527057)
2015
8
Leukostasis Retinopathy: A New Clinical Manifestation of Chronic Myeloid Leukemia With Severe Hyperleukocytosis. (26247460)
2015
9
How we approach a patient with symptoms of leukostasis requiring emergent leukocytapheresis. (26267387)
2015
10
Leukostasis in Children and Adolescents with Chronic Myeloid Leukemia: Japanese Pediatric Leukemia/Lymphoma Study Group. (26485422)
2015
11
Pathologic rupture of the spleen in a patient with acute myelogenous leukemia and leukostasis. (25031169)
2014
12
Transfusion medicine illustrated. Catastrophic basilar artery leukostasis in the setting of acute myeloid leukemia. (24724788)
2014
13
The effect of puerarin against IL-1I^-mediated leukostasis and apoptosis in retinal capillary endothelial cells (TR-iBRB2). (25593509)
2014
14
Leukostasis in an Adult with AML Presenting as Multiple High Attenuation Brain Masses on CT. (24551717)
2013
15
Genetic mutations in patients with acute myeloid leukemia and leukostasis. (23548579)
2013
16
Hyperleukocytosis, leukostasis and leukapheresis: practice management. (22364832)
2012
17
Intra-ophthalmic artery chemotherapy triggers vascular toxicity through endothelial cell inflammation and leukostasis. (22427570)
2012
18
CD11b+ bone marrow-derived monocytes are the major leukocyte subset responsible for retinal capillary leukostasis in experimental diabetes in mouse and express high levels of CCR5 in the circulation. (22677420)
2012
19
Therapeutic leukapheresis in patients with leukostasis secondary to acute myelogenous leukemia. (21574176)
2011
20
Reversal of leukostasis-related pulmonary distress syndrome after leukapheresis and low-dose chemotherapy in acute myeloid leukemia. (21825265)
2011
21
Pazopanib, a multitargeted tyrosine kinase inhibitor, reduces diabetic retinal vascular leukostasis and leakage. (21945644)
2011
22
Rapid treatment of leukostasis in leukemic mantle cell lymphoma using therapeutic leukapheresis: a case report. (22224069)
2011
23
TNFalpha is required for late BRB breakdown in diabetic retinopathy, and its inhibition prevents leukostasis and protects vessels and neurons from apoptosis. (21212173)
2011
24
Pulmonary leukostasis mimicking tuberculosis in endemic area. (20004472)
2010
25
Reliability of leukostasis grading score to identify patients with high-risk hyperleukocytosis. (19391131)
2009
26
Phosphomannopentaose sulfate (PI-88) inhibits retinal leukostasis in diabetic rat. (19250642)
2009
27
Targeting leukostasis for the treatment of early diabetic retinopathy. (19619127)
2009
28
TNF-alpha is critical for ischemia-induced leukostasis, but not retinal neovascularization nor VEGF-induced leakage. (17107717)
2007
29
Leukostasis and pigment epithelium-derived factor in rat models of diabetic retinopathy. (17653050)
2007
30
Role of NADPH oxidase and ANG II in diabetes-induced retinal leukostasis. (17652361)
2007
31
Images in clinical medicine. FLT3 Mutation and acute myelogenous leukemia with leukostasis. (17942876)
2007
32
Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood-retinal barrier breakdown in diabetic retinopathy. (17962481)
2007
33
A case report of therapeutic leukapheresis in an adult with chronic myelogenous leukemia presenting with hyperleukocytosis and leukostasis. (17381536)
2007
34
Inhibition of diabetic leukostasis and blood-retinal barrier breakdown with a soluble form of a receptor for advanced glycation end products. (17251488)
2007
35
Pigment epithelium-derived factor (PEDF) prevents diabetes- or advanced glycation end products (AGE)-elicited retinal leukostasis. (16797605)
2006
36
Hyperleukocytosis associated pulmonary leukostasis in acute leukaemia. (16909741)
2006
37
Role of angiotensin II in retinal leukostasis in the diabetic rat. (16822509)
2006
38
Correlation between expression of CD56/NCAM and severe leukostasis in hyperleukocytic acute myelomonocytic leukaemia. (16519701)
2006
39
Intravitreal injection of corticosteroid attenuates leukostasis and vascular leakage in experimental diabetic retina. (15790913)
2005
40
Grading of symptoms in hyperleukocytic leukaemia: a clinical model for the role of different blast types and promyelocytes in the development of leukostasis syndrome. (15876254)
2005
41
Case report: mantle cell lymphoma, prolymphocytoid variant, with leukostasis syndrome. (15197401)
2004
42
Management of life-threatening pulmonary leukostasis with single agent imatinib mesylate during CML myeloid blast crisis. (15377482)
2004
43
The role of advanced glycation end products in retinal microvascular leukostasis. (14507893)
2003
44
Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes: role of oxidants and protein kinase-C activation. (12606527)
2003
45
Cerebrovascular nodules in a patient with leukostasis. (12385403)
2002
46
Effective and selective prevention of retinal leukostasis in streptozotocin-induced diabetic rats using gliclazide. (12107755)
2002
47
Pulmonary leukostasis and the inhibition of airway neutrophil recruitment are early events in the endotoxemic rat. (11837792)
2002
48
Leukapheresis in chronic myelomonocytic leukemia with leukostasis syndrome: elevated serum lactate levels as an early sign of microcirculation failure. (12389624)
2002
49
The irreplaceable image: Cerebral leukostasis manifesting as multifocal intracerebral hemorrhage. (11694415)
2001
50
Endothelial cell activation by myeloblasts: molecular mechanisms of leukostasis and leukemic cell dissemination. (11264180)
2001

Variations for Leukostasis

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Expression for genes affiliated with Leukostasis

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Search GEO for disease gene expression data for Leukostasis.

Pathways for genes affiliated with Leukostasis

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Pathways related to Leukostasis according to GeneCards Suite gene sharing:

(show all 33)
idSuper pathwaysScoreTop Affiliating Genes
19.8ICAM1, VCAM1
29.7VCAM1, VEGFA
3
Show member pathways
9.5KDR, VEGFA
4
Show member pathways
9.5KDR, VEGFA
59.5KDR, VEGFA
6
Show member pathways
9.5KDR, VEGFA
79.5KDR, VEGFA
89.4ICAM1, MPO, VCAM1
99.4ICAM1, VCAM1, VEGFA
109.4NFATC2, NFATC4
119.4NFATC2, NFATC4
12
Show member pathways
9.4NFATC2, NFATC4
13
Show member pathways
9.3ICAM1, KDR, VCAM1
149.3ICAM1, SELE, VCAM1
159.3ICAM1, SELE, VCAM1
169.3ICAM1, SELE, VCAM1
179.3ICAM1, SELE, VCAM1
189.2KDR, VCAM1, VEGFA
199.1SELE, SELL
209.0NFATC2, NFATC4, VEGFA
21
Show member pathways
9.0NFATC2, NFATC4, VEGFA
229.0ICAM1, SELL, VCAM1
23
Show member pathways
8.9ICAM1, KDR, VCAM1, VEGFA
248.9ICAM1, SELE, VCAM1, VEGFA
25
Show member pathways
8.9ICAM1, SELE, VCAM1, VEGFA
26
Show member pathways
8.7ICAM1, NFATC2, NFATC4, VCAM1
278.7ICAM1, NFATC2, NFATC4, VCAM1
288.7MPO, NFATC2, NFATC4, VCAM1
29
Show member pathways
8.5KDR, NFATC2, NFATC4, VEGFA
30
Show member pathways
8.5KDR, NFATC2, NFATC4, VEGFA
318.5ICAM1, SELE, SELL, VCAM1
328.4ICAM1, KDR, SELE, VCAM1, VEGFA
33
Show member pathways
8.4ICAM1, KDR, SELE, VCAM1, VEGFA

GO Terms for genes affiliated with Leukostasis

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Cellular components related to Leukostasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.7ICAM1, SELL, VCAM1
2cell surfaceGO:00099869.3ICAM1, SELL, VCAM1, VEGFA
3membrane raftGO:00451219.1ICAM1, KDR, SELE
4extracellular spaceGO:00056159.1ICAM1, MPO, SELE, VCAM1, VEGFA

Biological processes related to Leukostasis according to GeneCards Suite gene sharing:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1membrane to membrane dockingGO:002261410.5ICAM1, VCAM1
2ovarian follicle developmentGO:000154110.4ICAM1, VEGFA
3branching involved in blood vessel morphogenesisGO:000156910.4NFATC4, VEGFA
4calcium-mediated signaling using intracellular calcium sourceGO:003558410.4KDR, VCAM1
5negative regulation of endothelial cell apoptotic processGO:200035210.3ICAM1, KDR
6leukocyte tethering or rollingGO:005090110.3SELE, VCAM1
7cell migration involved in sprouting angiogenesisGO:000204210.3KDR, VEGFA
8positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathwayGO:003803310.2KDR, VEGFA
9positive regulation of endothelial cell migrationGO:001059510.2KDR, VEGFA
10positive regulation of focal adhesion assemblyGO:005189410.2KDR, VEGFA
11positive regulation of positive chemotaxisGO:005092710.2KDR, VEGFA
12positive regulation of receptor internalizationGO:000209210.2SELE, VEGFA
13calcineurin-NFAT signaling cascadeGO:003317310.1NFATC2, NFATC4
14extracellular matrix organizationGO:003019810.0ICAM1, KDR, VCAM1
15heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesGO:000715710.0ICAM1, SELE, VCAM1
16leukocyte cell-cell adhesionGO:000715910.0ICAM1, SELE, VCAM1
17response to hypoxiaGO:000166610.0ICAM1, VCAM1, VEGFA
18cellular response to vascular endothelial growth factor stimulusGO:00359249.9KDR, VCAM1, VEGFA
19regulation of cell shapeGO:00083609.9ICAM1, KDR, VEGFA
20regulation of immune responseGO:00507769.6ICAM1, SELL, VCAM1
21leukocyte migrationGO:00509009.5ICAM1, SELE, SELL
22cell adhesionGO:00071559.2ICAM1, SELE, SELL, VCAM1
23response to lipopolysaccharideGO:00324968.9ICAM1, MPO, SELE, VCAM1

Molecular functions related to Leukostasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:00082019.4MPO, SELL, VEGFA
2integrin bindingGO:00051789.3ICAM1, KDR, VCAM1

Sources for Leukostasis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet