MCID: LKS001
MIFTS: 35

Leukostasis malady

Categories: Blood diseases

Aliases & Classifications for Leukostasis

Aliases & Descriptions for Leukostasis:

Name: Leukostasis 12 52 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:12986
MeSH 42 D018921
NCIt 47 C4062
SNOMED-CT 64 30419000
UMLS 69 C0282548

Summaries for Leukostasis

MalaCards based summary : Leukostasis is related to leukemia and subacute glomerulonephritis. An important gene associated with Leukostasis is ICAM1 (Intercellular Adhesion Molecule 1), and among its related pathways/superpathways are fMLP Pathway and Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways. Affiliated tissues include myeloid, endothelial and lung, and related phenotypes are cardiovascular system and cellular

Related Diseases for Leukostasis

Diseases related to Leukostasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 97)
id Related Disease Score Top Affiliating Genes
1 leukemia 10.4
2 subacute glomerulonephritis 10.2 ICAM1 MPO
3 uveitis 10.2 ICAM1 MPO
4 vaginal endometrial stromal tumor 10.2 ICAM1 VCAM1
5 ovarian clear cell malignant adenofibroma 10.2 ICAM1 VCAM1
6 tuberculous salpingitis 10.2 MPO VEGFA
7 retinitis 10.2
8 tonsil cancer 10.2 ICAM1 SELE
9 lymphedema 10.2 ICAM1 VCAM1
10 metal allergy 10.2 ICAM1 MPO
11 sparganosis 10.2 ICAM1 SELE
12 hirschsprung disease 7 10.2 SELE VCAM1
13 lymph node disease 10.2 ICAM1 SELE
14 kidney osteogenic sarcoma 10.2 KDR VEGFA
15 hand, foot and mouth disease 10.2 KDR VEGFA
16 cone-rod dystrophy 17 10.2 KDR VEGFA
17 vesiculobullous skin disease 10.1 KDR VEGFA
18 intracranial hypotension 10.1 KDR VEGFA
19 ependymoblastoma 10.1 ICAM1 MPO VCAM1
20 neuropathy with hearing impairment 10.1 KDR VEGFA
21 dislocation of ear ossicle 10.1 ICAM1 MPO VCAM1
22 benign idiopathic neonatal seizures 10.1 KDR VEGFA
23 multilocular clear cell renal cell carcinoma 10.1 ICAM1 VEGFA
24 benign secondary hypertension 10.1 ICAM1 MPO VCAM1
25 biemond syndrome ii 10.1 KDR VEGFA
26 factitious disorder 10.1 KDR VEGFA
27 heart valve disease 10.1 ICAM1 MPO VCAM1
28 glucocorticoid resistance 10.1 ICAM1 MPO VCAM1
29 epidermolysis bullosa simplex, sutosomal recessive 2 10.1 ICAM1 VCAM1 VEGFA
30 ovarian disease 10.1 KDR VEGFA
31 hypopyon ulcer 10.1 ICAM1 SELE VCAM1
32 macrodactyly of the foot 10.1 ICAM1 SELE VCAM1
33 periosteal chondrosarcoma 10.1 ICAM1 SELE VCAM1
34 chromophobe adenoma 10.1 ICAM1 SELL
35 right ventricle hypoplasia 10.1 ICAM1 SELE VCAM1
36 scalp dermatosis 10.1 KDR MPO
37 erb-duchenne and dejerine-klumpke palsies 10.1 ICAM1 SELE VCAM1
38 pyriform sinus cancer 10.1 ICAM1 VEGFA
39 dermatomycosis 10.1 ICAM1 MPO SELE
40 pemphigus vulgaris, familial 10.1 ICAM1 SELE VCAM1
41 synovium cancer 10.1 ICAM1 SELE VCAM1
42 cervix small cell carcinoma 10.1 ICAM1 SELE VCAM1
43 myelophthisic anemia 10.1 ICAM1 SELE VCAM1
44 esotropia 10.1 MPO SELE
45 prostate disease 10.1 ICAM1 SELE VEGFA
46 myeloid leukemia 10.1
47 chromoblastomycosis 10.0 ICAM1 SELL
48 vernal conjunctivitis 10.0 ICAM1 KDR VEGFA
49 congenital chloride diarrhea 10.0 SELE VCAM1 VEGFA
50 mental retardation, autosomal recessive 27 10.0 KDR MPO VEGFA

Graphical network of the top 20 diseases related to Leukostasis:



Diseases related to Leukostasis

Symptoms & Phenotypes for Leukostasis

MGI Mouse Phenotypes related to Leukostasis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.01 ICAM1 KDR MPO NFATC4 SELE SELL
2 cellular MP:0005384 9.97 ICAM1 KDR NFATC2 NFATC4 SELE SELL
3 growth/size/body region MP:0005378 9.92 ICAM1 KDR NFATC2 NFATC4 SELE SELL
4 hematopoietic system MP:0005397 9.91 VEGFA ICAM1 KDR MPO NFATC2 NFATC4
5 immune system MP:0005387 9.76 ICAM1 KDR MPO NFATC2 SELE SELL
6 muscle MP:0005369 9.43 NFATC4 VEGFA ICAM1 KDR MPO NFATC2
7 respiratory system MP:0005388 9.02 KDR NFATC2 SELE SELL VEGFA

Drugs & Therapeutics for Leukostasis

Search Clinical Trials , NIH Clinical Center for Leukostasis

Cochrane evidence based reviews: leukostasis

Genetic Tests for Leukostasis

Anatomical Context for Leukostasis

MalaCards organs/tissues related to Leukostasis:

39
Myeloid, Endothelial, Lung, Neutrophil, Monocytes, Brain, Spleen

Publications for Leukostasis

Articles related to Leukostasis:

(show top 50) (show all 115)
id Title Authors Year
1
Pulmonary Leukostasis: Treatment When Cytoreduction Does Not Suffice. ( 28060107 )
2017
2
Hyperleukocytosis and leukostasis: management of a medical emergency. ( 27967252 )
2016
3
Leukostasis in adult acute hyperleukocytic leukemia: a clinician's digest. ( 27018197 )
2016
4
Exchange Transfusion and Leukapheresis in Pediatric Patients with AML With High Risk of Early Death by Bleeding and Leukostasis. ( 26670831 )
2016
5
miR-15a/16 reduces retinal leukostasis through decreased pro-inflammatory signaling. ( 27931222 )
2016
6
Pulmonary leukostasis with severe respiratory impairment as a debut of acute myeloid leukemia. ( 26157660 )
2015
7
NFAT isoforms play distinct roles in TNFI+-induced retinal leukostasis. ( 26527057 )
2015
8
Leukostasis Retinopathy: A New Clinical Manifestation of Chronic Myeloid Leukemia With Severe Hyperleukocytosis. ( 26247460 )
2015
9
How we approach a patient with symptoms of leukostasis requiring emergent leukocytapheresis. ( 26267387 )
2015
10
Leukostasis in Children and Adolescents with Chronic Myeloid Leukemia: Japanese Pediatric Leukemia/Lymphoma Study Group. ( 26485422 )
2015
11
Pathologic rupture of the spleen in a patient with acute myelogenous leukemia and leukostasis. ( 25031169 )
2014
12
Transfusion medicine illustrated. Catastrophic basilar artery leukostasis in the setting of acute myeloid leukemia. ( 24724788 )
2014
13
The effect of puerarin against IL-1I^-mediated leukostasis and apoptosis in retinal capillary endothelial cells (TR-iBRB2). ( 25593509 )
2014
14
Leukostasis in an Adult with AML Presenting as Multiple High Attenuation Brain Masses on CT. ( 24551717 )
2013
15
Genetic mutations in patients with acute myeloid leukemia and leukostasis. ( 23548579 )
2013
16
Hyperleukocytosis, leukostasis and leukapheresis: practice management. ( 22364832 )
2012
17
Intra-ophthalmic artery chemotherapy triggers vascular toxicity through endothelial cell inflammation and leukostasis. ( 22427570 )
2012
18
CD11b+ bone marrow-derived monocytes are the major leukocyte subset responsible for retinal capillary leukostasis in experimental diabetes in mouse and express high levels of CCR5 in the circulation. ( 22677420 )
2012
19
Therapeutic leukapheresis in patients with leukostasis secondary to acute myelogenous leukemia. ( 21574176 )
2011
20
Reversal of leukostasis-related pulmonary distress syndrome after leukapheresis and low-dose chemotherapy in acute myeloid leukemia. ( 21825265 )
2011
21
Pazopanib, a multitargeted tyrosine kinase inhibitor, reduces diabetic retinal vascular leukostasis and leakage. ( 21945644 )
2011
22
Rapid treatment of leukostasis in leukemic mantle cell lymphoma using therapeutic leukapheresis: a case report. ( 22224069 )
2011
23
TNFalpha is required for late BRB breakdown in diabetic retinopathy, and its inhibition prevents leukostasis and protects vessels and neurons from apoptosis. ( 21212173 )
2011
24
Pulmonary leukostasis mimicking tuberculosis in endemic area. ( 20004472 )
2010
25
Reliability of leukostasis grading score to identify patients with high-risk hyperleukocytosis. ( 19391131 )
2009
26
Phosphomannopentaose sulfate (PI-88) inhibits retinal leukostasis in diabetic rat. ( 19250642 )
2009
27
Targeting leukostasis for the treatment of early diabetic retinopathy. ( 19619127 )
2009
28
TNF-alpha is critical for ischemia-induced leukostasis, but not retinal neovascularization nor VEGF-induced leakage. ( 17107717 )
2007
29
Leukostasis and pigment epithelium-derived factor in rat models of diabetic retinopathy. ( 17653050 )
2007
30
Role of NADPH oxidase and ANG II in diabetes-induced retinal leukostasis. ( 17652361 )
2007
31
Images in clinical medicine. FLT3 Mutation and acute myelogenous leukemia with leukostasis. ( 17942876 )
2007
32
Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood-retinal barrier breakdown in diabetic retinopathy. ( 17962481 )
2007
33
A case report of therapeutic leukapheresis in an adult with chronic myelogenous leukemia presenting with hyperleukocytosis and leukostasis. ( 17381536 )
2007
34
Inhibition of diabetic leukostasis and blood-retinal barrier breakdown with a soluble form of a receptor for advanced glycation end products. ( 17251488 )
2007
35
Pigment epithelium-derived factor (PEDF) prevents diabetes- or advanced glycation end products (AGE)-elicited retinal leukostasis. ( 16797605 )
2006
36
Hyperleukocytosis associated pulmonary leukostasis in acute leukaemia. ( 16909741 )
2006
37
Role of angiotensin II in retinal leukostasis in the diabetic rat. ( 16822509 )
2006
38
Correlation between expression of CD56/NCAM and severe leukostasis in hyperleukocytic acute myelomonocytic leukaemia. ( 16519701 )
2006
39
Intravitreal injection of corticosteroid attenuates leukostasis and vascular leakage in experimental diabetic retina. ( 15790913 )
2005
40
Grading of symptoms in hyperleukocytic leukaemia: a clinical model for the role of different blast types and promyelocytes in the development of leukostasis syndrome. ( 15876254 )
2005
41
Case report: mantle cell lymphoma, prolymphocytoid variant, with leukostasis syndrome. ( 15197401 )
2004
42
Management of life-threatening pulmonary leukostasis with single agent imatinib mesylate during CML myeloid blast crisis. ( 15377482 )
2004
43
The role of advanced glycation end products in retinal microvascular leukostasis. ( 14507893 )
2003
44
Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes: role of oxidants and protein kinase-C activation. ( 12606527 )
2003
45
Cerebrovascular nodules in a patient with leukostasis. ( 12385403 )
2002
46
Effective and selective prevention of retinal leukostasis in streptozotocin-induced diabetic rats using gliclazide. ( 12107755 )
2002
47
Pulmonary leukostasis and the inhibition of airway neutrophil recruitment are early events in the endotoxemic rat. ( 11837792 )
2002
48
Leukapheresis in chronic myelomonocytic leukemia with leukostasis syndrome: elevated serum lactate levels as an early sign of microcirculation failure. ( 12389624 )
2002
49
The irreplaceable image: Cerebral leukostasis manifesting as multifocal intracerebral hemorrhage. ( 11694415 )
2001
50
Endothelial cell activation by myeloblasts: molecular mechanisms of leukostasis and leukemic cell dissemination. ( 11264180 )
2001

Variations for Leukostasis

Expression for Leukostasis

Search GEO for disease gene expression data for Leukostasis.

Pathways for Leukostasis

Pathways related to Leukostasis according to GeneCards Suite gene sharing:

(show all 33)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.77 KDR NFATC2 NFATC4 VEGFA
2
Show member pathways
12.46 ICAM1 KDR VCAM1 VEGFA
3
Show member pathways
12.37 KDR NFATC2 NFATC4 VEGFA
4 12.32 MPO NFATC2 NFATC4 VCAM1
5 12.22 ICAM1 NFATC2 NFATC4 VCAM1
6
Show member pathways
12.13 ICAM1 NFATC2 NFATC4 VCAM1
7
Show member pathways
12.06 NFATC2 NFATC4 VEGFA
8
Show member pathways
11.96 ICAM1 KDR VCAM1
9
Show member pathways
11.94 ICAM1 KDR SELE VCAM1 VEGFA
10 11.89 ICAM1 SELL VCAM1
11 11.88 KDR VCAM1 VEGFA
12 11.83 ICAM1 SELE SELL VCAM1
13 11.79 ICAM1 VCAM1 VEGFA
14 11.76 ICAM1 SELE VCAM1
15 11.62 ICAM1 SELE VCAM1 VEGFA
16 11.36 ICAM1 SELE VCAM1
17 11.32 KDR VEGFA
18 11.32 NFATC2 NFATC4 VEGFA
19
Show member pathways
11.31 NFATC2 NFATC4
20 11.3 ICAM1 VCAM1
21 11.29 NFATC2 NFATC4
22 11.29 ICAM1 SELE VCAM1
23
Show member pathways
11.27 KDR VEGFA
24 11.23 SELE SELL
25 11.21 NFATC2 NFATC4
26 11.16 KDR VEGFA
27 11.16 ICAM1 KDR SELE VCAM1 VEGFA
28 11.12 ICAM1 SELE VCAM1
29
Show member pathways
11.06 ICAM1 SELE VCAM1 VEGFA
30 10.99 KDR VEGFA
31 10.83 VCAM1 VEGFA
32
Show member pathways
10.8 KDR VEGFA
33 10.64 ICAM1 MPO VCAM1

GO Terms for Leukostasis

Cellular components related to Leukostasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.55 ICAM1 MPO SELE VCAM1 VEGFA
2 external side of plasma membrane GO:0009897 9.43 ICAM1 SELL VCAM1
3 membrane raft GO:0045121 9.13 ICAM1 KDR SELE
4 cell surface GO:0009986 8.92 ICAM1 SELL VCAM1 VEGFA

Biological processes related to Leukostasis according to GeneCards Suite gene sharing:

(show all 23)
id Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.89 ICAM1 SELE SELL VCAM1
2 leukocyte migration GO:0050900 9.77 ICAM1 SELE SELL
3 extracellular matrix organization GO:0030198 9.75 ICAM1 KDR VCAM1
4 regulation of immune response GO:0050776 9.74 ICAM1 SELL VCAM1
5 response to hypoxia GO:0001666 9.7 ICAM1 VCAM1 VEGFA
6 regulation of cell shape GO:0008360 9.67 ICAM1 KDR VEGFA
7 positive regulation of endothelial cell migration GO:0010595 9.61 KDR VEGFA
8 ovarian follicle development GO:0001541 9.61 ICAM1 VEGFA
9 branching involved in blood vessel morphogenesis GO:0001569 9.58 NFATC4 VEGFA
10 negative regulation of endothelial cell apoptotic process GO:2000352 9.56 ICAM1 KDR
11 positive regulation of focal adhesion assembly GO:0051894 9.55 KDR VEGFA
12 positive regulation of receptor internalization GO:0002092 9.54 SELE VEGFA
13 calcium-mediated signaling using intracellular calcium source GO:0035584 9.51 KDR VCAM1
14 cell migration involved in sprouting angiogenesis GO:0002042 9.48 KDR VEGFA
15 leukocyte tethering or rolling GO:0050901 9.46 SELE VCAM1
16 response to lipopolysaccharide GO:0032496 9.46 ICAM1 MPO SELE VCAM1
17 positive regulation of positive chemotaxis GO:0050927 9.43 KDR VEGFA
18 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.43 ICAM1 SELE VCAM1
19 calcineurin-NFAT signaling cascade GO:0033173 9.4 NFATC2 NFATC4
20 membrane to membrane docking GO:0022614 9.37 ICAM1 VCAM1
21 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.32 KDR VEGFA
22 leukocyte cell-cell adhesion GO:0007159 9.13 ICAM1 SELE VCAM1
23 cellular response to vascular endothelial growth factor stimulus GO:0035924 8.8 KDR VCAM1 VEGFA

Molecular functions related to Leukostasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 9.13 MPO SELL VEGFA
2 integrin binding GO:0005178 8.8 ICAM1 KDR VCAM1

Sources for Leukostasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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