MCID: LKS001
MIFTS: 50

Leukostasis malady

Blood diseases category
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Summaries for Leukostasis

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Wikipedia:65 Leukostasis (aka symptomatic hyperleukocytosis) is a white blood cell count above 100,000/?L. It is... more...

MalaCards based summary: Leukostasis is related to respiratory failure and leukopenia. An important gene associated with Leukostasis is SELE (selectin E), and among its related pathways are Immune response Role of integrins in NK cells cytotoxicity and Staphylococcus aureus infection. The compounds 8 methoxypsoralen and sele have been mentioned in the context of this disorder. Affiliated tissues include lung, brain and myeloid, and related mouse phenotypes are no phenotypic analysis and vision/eye.

Aliases & Classifications for Leukostasis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 34MeSH, 57SNOMED-CT, 39NCIt
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Leukostasis, Aliases & Descriptions:

Name: Leukostasis 8 10 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood diseases


External Ids:

Disease Ontology8 DOID:12986
MeSH34 D018921
SNOMED-CT57 30419000
NCIt39 C4062

Related Diseases for Leukostasis

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Diseases related to Leukostasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 120)
idRelated DiseaseScoreTop Affiliating Genes
1respiratory failure30.6ICAM1, TNF
2leukopenia30.4C5AR1, MPO
3monocytic leukemia30.4TNF, VCAM1
4hypertension30.2SELE, VCAM1, ICAM1
5leukemia30.0TNF, MPO, SERPINF1, KDR, ICAM1, C5AR1
6pneumonia30.0TNF, MPO, ICAM1, C5AR1
7ischemia29.8C5AR1, ICAM1, KDR, SELE, MPO
8diabetic retinopathy29.8SERPINF1, KDR, VCAM1, ICAM1, AGER
9insulin resistance29.8TNF, SELE, VCAM1, AGER
10retinitis10.5
11skin disease10.4MPO
12diabetic macular edema10.4SERPINF1
13goodpasture syndrome10.4VCAM1, MPO
14peripheral vascular disease10.4MPO, SELE
15plummer's disease10.3ICAM1, SELE
16rapidly progressive glomerulonephritis10.3MPO, ICAM1
17rhinitis10.3VCAM1, ICAM1
18allergic contact dermatitis10.3SELE, ICAM1
19arteriosclerosis obliterans10.3ICAM1, VCAM1
20inclusion body myositis10.3ICAM1, VCAM1
21myeloid leukemia10.3
22granulocytopenia10.3
23allergic rhinitis10.3MPO, ICAM1
24wegener's granulomatosis10.3MPO, SELE
25antiphospholipid syndrome10.3SELE, VCAM1
26oral lichen planus10.3VCAM1, ICAM1
27plasmodium falciparum malaria10.3ICAM1, SELE
28diabetic angiopathy10.3AGER, SELE
29vernal keratoconjunctivitis10.3ICAM1, VCAM1
30adult respiratory distress syndrome10.3SELE, TNF
31acute myeloid leukemia10.3
32arteriosclerosis10.3ICAM1, VCAM1
33psoriatic arthritis10.3SELE, TNF
34sickle cell disease10.3SELE, VCAM1
35hyperhomocysteinemia10.2VCAM1, SELE
36behcet's disease10.2SELE, TNF
37alcoholic hepatitis10.2ICAM1, TNF
38rheumatoid vasculitis10.2SELE, VCAM1, ICAM1
39pulmonary sarcoidosis10.2TNF, ICAM1
40hepatitis10.2
41endotheliitis10.2
42immunoglobulin a vasculitis10.2ICAM1, VCAM1, MPO
43polymyositis10.2SELE, VCAM1, ICAM1
44dermatomyositis10.2ICAM1, VCAM1
45stroke, ischemic10.2SELE, VCAM1, ICAM1
46dermatitis10.2SELE, VCAM1, ICAM1
47allergic asthma10.2ICAM1, VCAM1, SELE
48systemic scleroderma10.2ICAM1, VCAM1, SELE
49urticaria10.2SELE, C5AR1
50lichen planus10.2C5AR1, ICAM1

Graphical network of the top 20 diseases related to Leukostasis:



Diseases related to leukostasis

Symptoms for Leukostasis

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Drugs & Therapeutics for Leukostasis

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Drug clinical trials:

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Genetic Tests for Leukostasis

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Anatomical Context for Leukostasis

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MalaCards organs/tissues related to Leukostasis:

32
Lung, Brain, Myeloid, Endothelial, Neutrophil, Monocytes, Bone, Spleen, Retina

Animal Models for Leukostasis or affiliated genes

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MGI Mouse Phenotypes related to Leukostasis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.1AGER, VCAM1, KDR, TNF
2MP:00053917.9TNF, SERPINF1, SELE, KDR, ICAM1
3MP:00053697.8AGER, ICAM1, KDR, MPO, TNF
4MP:00107717.7TNF, SELE, KDR, ICAM1, AGER
5MP:00107687.2TNF, MPO, SELE, KDR, VCAM1, ICAM1
6MP:00053787.1TNF, SELE, KDR, VCAM1, ICAM1, AGER
7MP:00053856.8AGER, TNF, MPO, SERPINF1, SELE, KDR
8MP:00053976.7TNF, MPO, SELE, KDR, VCAM1, ICAM1
9MP:00053876.7TNF, MPO, SELE, KDR, VCAM1, ICAM1
10MP:00053766.7TNF, MPO, SELE, KDR, VCAM1, ICAM1

Publications for Leukostasis

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Articles related to Leukostasis:

(show top 50)    (show all 102)
idTitleAuthorsYear
1
Pathologic rupture of the spleen in a patient with acute myelogenous leukemia and leukostasis. (25031169)
2014
2
Transfusion medicine illustrated. Catastrophic basilar artery leukostasis in the setting of acute myeloid leukemia. (24724788)
2014
3
Genetic mutations in patients with acute myeloid leukemia and leukostasis. (23548579)
2013
4
Leukostasis in an Adult with AML Presenting as Multiple High Attenuation Brain Masses on CT. (24551717)
2013
5
CD11b+ bone marrow-derived monocytes are the major leukocyte subset responsible for retinal capillary leukostasis in experimental diabetes in mouse and express high levels of CCR5 in the circulation. (22677420)
2012
6
Hyperleukocytosis, leukostasis and leukapheresis: practice management. (22364832)
2012
7
Reversal of leukostasis-related pulmonary distress syndrome after leukapheresis and low-dose chemotherapy in acute myeloid leukemia. (21825265)
2011
8
Rapid treatment of leukostasis in leukemic mantle cell lymphoma using therapeutic leukapheresis: a case report. (22224069)
2011
9
Phosphomannopentaose sulfate (PI-88) inhibits retinal leukostasis in diabetic rat. (19250642)
2009
10
Targeting leukostasis for the treatment of early diabetic retinopathy. (19619127)
2009
11
Reliability of leukostasis grading score to identify patients with high-risk hyperleukocytosis. (19391131)
2009
12
Leukostasis and pigment epithelium-derived factor in rat models of diabetic retinopathy. (17653050)
2007
13
Role of NADPH oxidase and ANG II in diabetes-induced retinal leukostasis. (17652361)
2007
14
Inhibition of diabetic leukostasis and blood-retinal barrier breakdown with a soluble form of a receptor for advanced glycation end products. (17251488)
2007
15
Correlation between expression of CD56/NCAM and severe leukostasis in hyperleukocytic acute myelomonocytic leukaemia. (16519701)
2006
16
Intravitreal injection of corticosteroid attenuates leukostasis and vascular leakage in experimental diabetic retina. (15790913)
2005
17
Case report: mantle cell lymphoma, prolymphocytoid variant, with leukostasis syndrome. (15197401)
2004
18
Management of life-threatening pulmonary leukostasis with single agent imatinib mesylate during CML myeloid blast crisis. (15377482)
2004
19
The role of advanced glycation end products in retinal microvascular leukostasis. (14507893)
2003
20
Pulmonary leukostasis and the inhibition of airway neutrophil recruitment are early events in the endotoxemic rat. (11837792)
2002
21
Effective and selective prevention of retinal leukostasis in streptozotocin-induced diabetic rats using gliclazide. (12107755)
2002
22
Leukapheresis in chronic myelomonocytic leukemia with leukostasis syndrome: elevated serum lactate levels as an early sign of microcirculation failure. (12389624)
2002
23
Endothelial cell activation by myeloblasts: molecular mechanisms of leukostasis and leukemic cell dissemination. (11264180)
2001
24
Integrin-mediated neutrophil adhesion and retinal leukostasis in diabetes. (10752954)
2000
25
Pulmonary leukostasis mimicking pulmonary embolism. (10654454)
2000
26
Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition. (10485912)
1999
27
Use of genetically manipulated strains of Clostridium perfringens reveals that both alpha-toxin and theta-toxin are required for vascular leukostasis to occur in experimental gas gangrene. (10456947)
1999
28
Pressure-related capillary leukostasis following ischemia-reperfusion and hemorrhagic shock. (8342655)
1993
29
Involvement of the complement system in the pathogenesis of pulmonary leukostasis in experimental myelocytic leukemia. (8412322)
1993
30
Treatment of acute promyelocytic leukemia with all-trans retinoic acid: successful control of hyperleukocytosis and leukostasis syndrome with leukaphereses and hydroxyurea. (8372818)
1993
31
Pulmonary leukostasis secondary to all-trans retinoic acid in the treatment of acute promyelocytic leukemia in first relapse. (1602800)
1992
32
Pulmonary leukostasis without hyperleukocytosis: a clinicopathologic study of 16 cases. (1566743)
1992
33
Development of pulmonary leukostasis in experimental myelocytic leukemia in the Brown-Norway rat. (1552745)
1992
34
The state of leucocyte adhesiveness/aggregation (LAA) in the peripheral blood of burned mice: an early and sensitive inflammatory indicator and a marker of pulmonary leukostasis. (1793493)
1991
35
Effects of cardiopulmonary bypass on pulmonary leukostasis and complement activation. (3190431)
1988
36
Interleukin-1-induced granulocytopenia and pulmonary leukostasis in rabbits. (3031000)
1987
37
Quantitative estimation of leukostasis in the posttraumatic lung--canine and human autopsy data. (3615443)
1987
38
Pulmonary leukostasis in a patient with chronic myeloid leukemia. (3475250)
1986
39
Aleukaemic leukostasis in a case of large cell non-Hodgkin's lymphoma: report of a case with a distinctive central nervous system involvement. (3760899)
1986
40
Streptococcus pneumoniae-induced alterations in levels of circulating thromboxane and prostacyclin: dissociation from granulocytopenia, thrombocytopenia, and pulmonary leukostasis. (3510262)
1986
41
Intravascular leukostasis in a horse with myelomonocytic leukemia. (6592873)
1984
42
Reversal of hemodialysis granulocytopenia and pulmonary leukostasis: A clinical manifestation of selective down-regulation of granulocyte responses to C5adesarg. (7229031)
1981
43
Pneumococcus-induced granulocytopenia and pulmonary leukostasis in rabbits. (7452094)
1981
44
Complement-induced vascular leukostasis. Its role in tissue injury. (6893656)
1980
45
Pulmonary leukostasis and its relationship to pulmonary dysfunction in sheep and rabbits. (7351034)
1980
46
Leukostasis in SAczary syndrome. (439311)
1979
47
Rapid cytoreduction in acute leukemia. Management of cerebral leukostasis by cell pheresis. (272799)
1978
48
Hydroxyurea in the prevention of the effects of leukostasis in acute leukemia. (268956)
1977
49
Hemodialysis leukopenia. Pulmonary vascular leukostasis resulting from complement activation by dialyzer cellophane membranes. (856872)
1977
50
The pathologic characteristics of leukostasis and leukemic nodules occurring in the central nervous system of guinea pigs with L2C/NB leukemia. (1245856)
1976

Variations for Leukostasis

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Expression for genes affiliated with Leukostasis

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Expression patterns in normal tissues for genes affiliated with Leukostasis

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Pathways for genes affiliated with Leukostasis

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Compounds for genes affiliated with Leukostasis

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Compounds related to Leukostasis according to GeneCards/GeneDecks:

(show top 50)    (show all 146)
idCompoundScoreTop Affiliating Genes
18 methoxypsoralen449.7VCAM1, ICAM1, SELE
2sele449.6SELE, ICAM1, VCAM1
3gliclazide44 50 1111.5ICAM1, VCAM1, SELE, MPO
4mycophenolic acid44 50 1111.4VCAM1, ICAM1, SELE
5ro 31-7549449.3SELE, TNF, VCAM1
6celastrol44 6110.3TNF, VCAM1, SELE
7hcec449.2KDR, VCAM1, ICAM1
8ulinastatin449.2ICAM1, MPO, TNF
9slex449.1VCAM1, SELE, ICAM1
10fluticasone propionate44 50 61 1112.0VCAM1, TNF, MPO, SELE
11nadph44 2410.0VCAM1, SERPINF1, MPO, AGER
12sulfasalazine28 44 50 1112.0MPO, TNF, SELE, ICAM1
13polymyxin b449.0TNF, VCAM1, SELE, ICAM1
14okt3449.0TNF, VCAM1, SELE, ICAM1
15groalpha449.0TNF, SELE, VCAM1, ICAM1
16budesonide44 50 1110.9ICAM1, VCAM1, MPO, TNF
17fenofibrate44 50 1110.9SELE, VCAM1, ICAM1, TNF
18pdtc448.9VCAM1, SELE, ICAM1, TNF
19pentoxifylline44 119.9TNF, MPO, VCAM1, ICAM1
20atorvastatin44 50 28 24 1112.8TNF, SELE, VCAM1, ICAM1
21n-formylmethionyl-leucylphenylalanine448.7C5AR1, TNF, ICAM1, MPO
22cyclophosphamide44 50 1110.7SELE, KDR, VCAM1, MPO
23troglitazone44 28 61 1111.7VCAM1, SELE, ICAM1, TNF
24prednisolone44 28 1110.7MPO, VCAM1, C5AR1, TNF
25apocynin44 619.6TNF, MPO, ICAM1, VCAM1, SELE
268-isoprostane448.6ICAM1, VCAM1, SELE, MPO, TNF
27matrigel448.6ICAM1, SELE, SERPINF1, VCAM1, KDR
28herbimycin a44 619.6VCAM1, SELE, ICAM1, TNF
29diphenyleneiodonium448.5VCAM1, ICAM1, MPO, TNF, SERPINF1
30endotoxin448.4SELE, TNF, VCAM1, C5AR1, ICAM1
31fmlp448.4C5AR1, MPO, VCAM1, ICAM1, TNF
32rantes448.4TNF, C5AR1, SELE, VCAM1, ICAM1
33sb 20358044 619.4C5AR1, ICAM1, TNF, SELE, VCAM1
34simvastatin44 50 61 28 24 1113.3VCAM1, KDR, SELE, ICAM1, TNF
35fibrinogen448.3ICAM1, VCAM1, C5AR1, TNF, SELE
36ly294002448.2TNF, SELE, KDR, VCAM1, ICAM1
37genistein44 28 61 2 24 1113.2ICAM1, TNF, SELE, KDR, VCAM1
38histamine44 28 2410.1SELE, TNF, ICAM1, C5AR1, VCAM1, MPO
39pge2448.1C5AR1, ICAM1, VCAM1, SELE, TNF, MPO
40lactate448.0TNF, MPO, VCAM1, SELE, ICAM1, KDR
41superoxide44 249.0AGER, TNF, MPO, VCAM1, C5AR1
42heparin44 28 24 1110.7AGER, VCAM1, KDR, SELE, SERPINF1, MPO
43h2o2447.7MPO, C5AR1, KDR, SERPINF1, ICAM1, TNF
44retinoic acid44 248.6KDR, TNF, MPO, VCAM1, ICAM1, SERPINF1
45oxygen44 248.4TNF, ICAM1, MPO, SERPINF1, VCAM1, C5AR1
46prostacyclin447.3KDR, VCAM1, ICAM1, SELE, C5AR1, TNF
47n acetylcysteine447.1ICAM1, SELE, SERPINF1, MPO, TNF, VCAM1
48serine446.9SERPINF1, MPO, SELE, KDR, VCAM1, C5AR1
49vegf446.5SERPINF1, SELE, MPO, KDR, TNF, VCAM1
50nitric oxide44 24 118.5SELE, MPO, AGER, ICAM1, SERPINF1, KDR

GO Terms for genes affiliated with Leukostasis

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Cellular components related to Leukostasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099868.8C5AR1, VCAM1, TNF
2membrane raftGO:0451218.4KDR, SELE, TNF
3external side of plasma membraneGO:0098978.3TNF, KDR, VCAM1, ICAM1
4extracellular spaceGO:0056157.9ICAM1, VCAM1, SELE, SERPINF1, MPO, TNF
5integral component of plasma membraneGO:0058877.5TNF, KDR, ICAM1, C5AR1, AGER
6plasma membraneGO:0058866.9TNF, SELE, KDR, VCAM1, ICAM1, C5AR1

Biological processes related to Leukostasis according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1membrane to membrane dockingGO:02261410.0VCAM1, ICAM1
2cellular response to glucose stimulusGO:0713339.9ICAM1, VCAM1
3response to ionizing radiationGO:0102129.8ICAM1, VCAM1
4cellular response to vascular endothelial growth factor stimulusGO:0359249.7KDR, VCAM1
5leukocyte cell-cell adhesionGO:0071599.7SELE, VCAM1, ICAM1
6heterophilic cell-cell adhesionGO:0071579.7ICAM1, VCAM1, SELE
7interferon-gamma-mediated signaling pathwayGO:0603339.7ICAM1, VCAM1
8cellular response to tumor necrosis factorGO:0713569.6ICAM1, VCAM1
9ovarian follicle developmentGO:0015419.6KDR, ICAM1
10agingGO:0075689.6MPO, SERPINF1, VCAM1
11negative regulation of growth of symbiont in hostGO:0441309.6MPO, TNF
12positive regulation of nitric oxide biosynthetic processGO:0454299.5ICAM1, TNF
13calcium-mediated signalingGO:0197229.4SELE, TNF
14defense response to Gram-positive bacteriumGO:0508309.3C5AR1, TNF
15activation of phospholipase C activityGO:0072029.3C5AR1, SELE
16response to mechanical stimulusGO:0096129.3TNF, MPO
17leukocyte tethering or rollingGO:0509019.3VCAM1, SELE, TNF
18response to lipopolysaccharideGO:0324969.3C5AR1, VCAM1, SELE, MPO
19positive regulation of NF-kappaB transcription factor activityGO:0510929.0AGER, ICAM1, TNF
20positive regulation of ERK1 and ERK2 cascadeGO:0703748.8C5AR1, KDR, TNF
21inflammatory responseGO:0069548.6TNF, SELE, C5AR1, AGER
22extracellular matrix organizationGO:0301988.6ICAM1, VCAM1, KDR, TNF

Molecular functions related to Leukostasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:0048889.2AGER, ICAM1, SELE
2integrin bindingGO:0051788.8ICAM1, VCAM1, KDR

Products for genes affiliated with Leukostasis

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Sources for Leukostasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet