MCID: LWS001
MIFTS: 17

Lewis-Sumner Syndrome

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Lewis-Sumner Syndrome

MalaCards integrated aliases for Lewis-Sumner Syndrome:

Name: Lewis-Sumner Syndrome 50 56
Multifocal Acquired Demyelinating Sensory and Motor Neuropathy 50 56
Madsam 50 56

Characteristics:

Orphanet epidemiological data:

56
lewis-sumner syndrome
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 56  
Rare neurological diseases


External Ids:

Orphanet 56 ORPHA48162
UMLS via Orphanet 70 C1695985
ICD10 via Orphanet 34 G61.8

Summaries for Lewis-Sumner Syndrome

NIH Rare Diseases : 50 lewis-sumner syndrome (also known as multifocal acquired demyelinating sensory and motor neuropathy) is a neurological condition affecting primarily the arms and hands (upper limbs). the symptoms are a result of inflammation of the nerves leading to the upper body and the destruction of the fatty covering that protects the nerves (myelin sheath). lewis sumner syndrome is an acquired disorder, and the exact cause of the condition is not known. lewis sumner syndrome may be difficult to distinguish from other forms of demyelinating neuropathies, but diagnosis may be possible through nerve conduction studies or a specific type of imaging test, called mri with t2 stir. treatment with intravenous immunoglobulin (ivig) therapy has been successful in reducing the symptoms of the disease. last updated: 8/4/2016

MalaCards based summary : Lewis-Sumner Syndrome, also known as multifocal acquired demyelinating sensory and motor neuropathy, is related to chronic inflammatory demyelinating polyneuropathy and neuropathy. Affiliated tissues include testes.

Related Diseases for Lewis-Sumner Syndrome

Diseases related to Lewis-Sumner Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 20)
id Related Disease Score Top Affiliating Genes
1 chronic inflammatory demyelinating polyneuropathy 11.4
2 neuropathy 10.4
3 multifocal motor neuropathy 10.3
4 rheumatoid arthritis 10.1
5 arthritis 10.1
6 polyradiculoneuropathy 10.1
7 chronic inflammatory demyelinating polyradiculoneuropathy 9.9
8 demyelinating polyneuropathy 9.9
9 hepatitis c virus 9.9
10 neuronitis 9.9
11 tangier disease 9.9
12 psoriasis 9.9
13 hepatitis 9.9
14 motor neuron disease 9.9
15 ulcerative colitis 9.9
16 colitis 9.9
17 polyneuropathy 9.9
18 hepatitis c 9.9
19 laryngitis 9.9
20 ulnar neuropathy 9.8

Graphical network of the top 20 diseases related to Lewis-Sumner Syndrome:



Diseases related to Lewis-Sumner Syndrome

Symptoms & Phenotypes for Lewis-Sumner Syndrome

Drugs & Therapeutics for Lewis-Sumner Syndrome

Search Clinical Trials , NIH Clinical Center for Lewis-Sumner Syndrome

Genetic Tests for Lewis-Sumner Syndrome

Anatomical Context for Lewis-Sumner Syndrome

MalaCards organs/tissues related to Lewis-Sumner Syndrome:

39
Testes

Publications for Lewis-Sumner Syndrome

Articles related to Lewis-Sumner Syndrome:

(show all 26)
id Title Authors Year
1
Lewis-Sumner Syndrome Manifesting as Unilateral Vocal Fold Paresis and Laryngeal Fasciculations. ( 28781097 )
2017
2
Lewis-Sumner syndrome associated with infliximab therapy for psoriasis. ( 28225983 )
2017
3
Lewis-Sumner syndrome in a patient with rheumatoid arthritis: Link between rheumatoid arthritis and demyelinating polyradiculoneuropathies. ( 28363822 )
2017
4
Lewis-Sumner syndrome associated with infliximab therapy in ulcerative colitis. ( 26838522 )
2016
5
Asymmetric sensory nerve action potential amplitudes as an early hint for diagnosing Lewis-Sumner syndrome. ( 27709506 )
2016
6
Chronic inflammatory demyelinating polyneuropathy variant (Lewis- Sumner syndrome) in HIV. ( 27727849 )
2016
7
Diagnostic value of MR imaging in the Lewis-Sumner syndrome: a case series. ( 24825730 )
2014
8
Long-term treatment of Lewis-Sumner syndrome with subcutaneous immunoglobulin infusions. ( 23095259 )
2013
9
Motor root conduction block in the Lewis-Sumner syndrome. ( 21321496 )
2011
10
Response to treatment in patients with Lewis-Sumner syndrome. ( 21755505 )
2011
11
A case of Lewis-Sumner syndrome showing dramatic improvement after plasma exchange. ( 20592909 )
2010
12
Treatment of chronic immune-mediated neuropathies: chronic inflammatory demyelinating polyradiculoneuropathy, multifocal motor neuropathy, and the Lewis-Sumner syndrome. ( 20941678 )
2010
13
Lewis-sumner syndrome of pure upper-limb onset: diagnostic, prognostic, and therapeutic features. ( 19145651 )
2009
14
Lewis-Sumner syndrome associated with infliximab therapy in rheumatoid arthritis. ( 18671292 )
2008
15
Lewis-Sumner syndrome and Tangier disease. ( 18625867 )
2008
16
Lewis-Sumner syndrome in hepatitis C virus infection: a possible pathogenetic association with therapeutic problems. ( 16453326 )
2006
17
A case of Lewis-Sumner syndrome with conduction abnormalities only in the brachial plexus and roots. ( 16609975 )
2006
18
Hypoglossal neuropathy in Lewis-Sumner syndrome masquerading as motor neuron disease. ( 16832106 )
2006
19
Lewis-Sumner syndrome and multifocal motor neuropathy. ( 15536613 )
2005
20
Follow-up study and response to treatment in 23 patients with Lewis-Sumner syndrome. ( 15289267 )
2004
21
Massive peripheral nerve hypertrophy in a patient with multifocal upper limb demyelinating neuropathy (Lewis-Sumner syndrome). ( 11851033 )
2001
22
Are multifocal motor neuropathy and Lewis-Sumner syndrome distinct nosologic entities? ( 10331352 )
1999
23
Multifocal motor neuropathy and Lewis Sumner syndrome: a clinical spectrum. ( 10567093 )
1999
24
Multifocal motor neuropathy and Lewis Sumner syndrome: two distinct entities. ( 10567092 )
1999
25
Multifocal acquired demyelinating sensory and motor neuropathy: the Lewis-Sumner syndrome. ( 10331353 )
1999
26
Chronic multifocal neuropathy with persistent conduction block (Lewis-Sumner syndrome). A clinico-morphologic study of two further cases with review of the literature. ( 8287628 )
1993

Variations for Lewis-Sumner Syndrome

Expression for Lewis-Sumner Syndrome

Search GEO for disease gene expression data for Lewis-Sumner Syndrome.

Pathways for Lewis-Sumner Syndrome

GO Terms for Lewis-Sumner Syndrome

Sources for Lewis-Sumner Syndrome

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16 ExPASy
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59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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