DLB
MCID: LWY001
MIFTS: 65

Lewy Body Dementia (DLB) malady

Summaries for Lewy Body Dementia

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42NIH Rare Diseases, 33MedlinePlus, 43NINDS, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Lewy body disease is one of the most common causes of dementia in the elderly. dementia is the loss of mental functions severe enough to affect normal activities and relationships. lewy body disease happens when abnormal structures, called lewy bodies, build up in areas of the brain. the disease may cause a wide range of symptoms, including changes in alertness and attention hallucinations problems with movement and posture muscle stiffness confusion loss of memory lewy body disease can be hard to diagnose, because parkinson's disease and alzheimer's disease cause similar symptoms. scientists think that lewy body disease might be related to these diseases, or that they sometimes happen together. lewy body disease usually begins between the ages of 50 and 85. the disease gets worse over time. there is no cure. treatment focuses on drugs to help symptoms. nih: national institute of neurological disorders and stroke

MalaCards: Lewy Body Dementia, also known as lewy body disease, is related to dementia and alzheimer's disease. An important gene associated with Lewy Body Dementia is SNCB (synuclein, beta), and among its related pathways are Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction) and Acetylcholine Synthesis. The compounds phenserine and ddvp have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and testes, and related mouse phenotypes are taste/olfaction and no phenotypic analysis.

NIH Rare Diseases:42 Lewy bodies dementia is one of the most common types of dementia. the central feature of this condition is progressive cognitive decline, combined with three additional defining features: (1) fluctuations in alertness and attention, such as frequent drowsiness, lethargy, lengthy periods of time spent staring into space, or disorganized speech; (2) recurrent visual hallucinations, and (3) parkinsonian motor symptoms, such as rigidity and the loss of spontaneous movement. although the exact cause of this condition is unknown, symptoms result from the build-up of abnormal structures, called lewy bodies, inside the brain. this condition usually occurs sporadically, in people with no known family history of the disease. however, rare familial cases have been reported. last updated: 1/12/2012

NINDS:43 Is one of the most common types of progressive dementia. The central features of DLB include progressive cognitive decline, ?fluctuations? in alertness and attention, visual hallucinations, and parkinsonian motor symptoms, such as slowness of movement, difficulty walking, or rigidity.

Wikipedia:63 Dementia with Lewy bodies (DLB), also known under a variety of other names including Lewy body dementia,... more...

Description from OMIM:46 127750

Aliases & Classifications for Lewy Body Dementia

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8Disease Ontology, 42NIH Rare Diseases, 43NINDS, 46OMIM, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 9diseasecard, 22GTR, 56SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH
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Aliases & Descriptions:

lewy body dementia 8 42 43 46 10
lewy body disease 8 42 44 33 60
dementia, lewy body 9 22 46
autosomal dominant diffuse lewy body disease 42 60
dementia with lewy bodies 8 43
diffuse lewy body disease 8 42
senile dementia of the lewy body type 8
dlb 42


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Disease Ontology8 DOID:12217
NCIt39 C84826
OMIM46 127750
ICD9CM27 331.82
MeSH34 D020961

Related Diseases for Lewy Body Dementia

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17GeneCards, 18GeneDecks
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Diseases related to Lewy Body Dementia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 101)
idRelated DiseaseScoreTop Affiliating Genes
1dementia31.8BCHE, ACHE, SLC6A3, GBA, CHAT, SNCA
2alzheimer's disease31.3RPS27A, HTR2A, APP, APOE, SNCB, SNCG
3parkinson's disease31.1BCHE, ACHE, SLC18A2, SLC6A3, GBA, CHRNA4
4vascular dementia30.8APOE
5brain disease30.7APP, SNCA, CHAT, BCHE
6frontotemporal dementia30.7RPS27A, APP, APOE, SNCA, ACHE
7multiple system atrophy30.7TPPP, SLC6A3, CHAT, SNCA, SNCG, SNCB
8rem sleep behavior disorder30.4SNCA, SLC6A3
9huntington's disease30.4RPS27A, APP, SNCA, CHAT, SLC6A3, ACHE
10multiple sclerosis30.3APOE
11cerebral amyloid angiopathy30.3APOE, APP
12striatonigral degeneration30.3RPS27A, SNCA, SLC6A3
13progressive supranuclear palsy30.3APOE, SLC6A3
14neuroaxonal dystrophy30.3RPS27A, SNCA
15amyotrophic lateral sclerosis30.3SLC6A3, CHAT, SNCA, APP, RPS27A
16movement disease30.3RPS27A, SNCG, SNCA, SLC6A3, SLC18A2
17pick's disease30.3RPS27A, APP, APOE, SNCA, CHAT, ACHE
18prion disease30.2RPS27A, APP, APOE, SNCA, CHAT, SLC6A3
19tauopathy30.2RPS27A, APP, SNCA
20cerebrovascular disease30.2ACHE, SLC6A3, APOE, APP
21hyperhomocysteinemia30.2BCHE, APOE
22schizophrenia30.2HTR2A, SNCA, CHAT, CHRNA4, SLC6A3, SLC18A2
23psychotic disorder30.1HTR2A, SLC6A3, ACHE
24neuroleptic malignant syndrome10.5
25vascular disease10.4
26capgras syndrome10.4
27neuronitis10.3
28sleep disorder10.3
29relapsing polychondritis10.2
30schizoaffective disorder10.2
31cortical blindness10.2
32aphasia10.2
33basal ganglia disease10.2
34cerebral degeneration10.2
35nervous system disease10.2
36lateral sclerosis10.2
37eye disease10.2
38bruxism10.2
39parametritis10.2
40cerebritis10.2
41skin disease10.2
42tuberculosis10.2
43thalamic disease10.1
44submandibular gland disease10.1
45anxiety disorder10.1
46degenerative nerve diseases10.1
47neuroblastoma10.0CHAT
48hydrocephalus10.0GBA
49hereditary cerebral amyloid angiopathy10.0APP
50gaucher's disease10.0GBA

Graphical network of the top 20 diseases related to Lewy Body Dementia:



Diseases related to lewy body dementia

Clinical Features for Lewy Body Dementia

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46OMIM
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Clinical features from OMIM:

127750

Clinical synopsis from OMIM:

127750

Drugs & Therapeutics for Lewy Body Dementia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Lewy Body Dementia

Drug clinical trials:

Search ClinicalTrials for Lewy Body Dementia

Search NIH Clinical Center for Lewy Body Dementia

Search CenterWatch for Lewy Body Dementia

Genetic Tests for Lewy Body Dementia

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22GTR
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Genetic tests related to Lewy Body Dementia:

id Genetic test Affiliating Genes
1 Lewy Body Dementia22

Anatomical Context for Lewy Body Dementia

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32MalaCards
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MalaCards organs/tissues related to Lewy Body Dementia:

32
Brain, Cortex, Testes, Heart, Eye, Skin, T cells, Temporal lobe

Animal Models for Lewy Body Dementia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Lewy Body Dementia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539410.2SLC6A3, SNCA
2MP:00030129.7APOE, SNCB, SNCA, CHRNA4, ACHE, APP
3MP:00053699.3HTR2A, APP, APOE, CHAT, SLC6A3, SLC18A2
4MP:00036318.8SNCA, SNCG, SNCB, APOE, APP, ATP13A2
5MP:00053868.8ACHE, HTR2A, APP, APOE, SNCG, SNCA
6MP:00053768.7SNCA, SNCG, SNCB, APOE, APP, CHAT
7MP:00107688.6APP, APOE, SNCB, SNCA, CHAT, CHRNA4

Publications for Lewy Body Dementia

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Sources:
50PubMed
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Articles related to Lewy Body Dementia:

(show top 50)    (show all 344)
idTitleAuthorsYear
1
The New Qualitative Scoring MMSE Pentagon Test (QSPT) as a Valid Screening Tool between Autopsy-Confirmed Dementia with Lewy Bodies and Alzheimer's Disease. (24284368)
2013
2
Neuropathological correlates of volumetric MRI in autopsy-confirmed Lewy body dementia. (21353336)
2012
3
Differentiation of frontotemporal dementia from dementia with Lewy bodies using FP-CIT SPECT. (22869921)
2012
4
Olanzapine-induced neuroleptic malignant syndrome in a patient with probable dementia with Lewy bodies. (23224461)
2012
5
TRIM9, a novel brain-specific E3 ubiquitin ligase, is repressed in the brain of Parkinson's disease and dementia with Lewy bodies. (20085810)
2010
6
Quantification of myelin loss in frontal lobe white matter in vascular dementia, Alzheimer's disease, and dementia with Lewy bodies. (20091409)
2010
7
The decrease of I^-synuclein in cortical brain areas defines a molecular subgroup of dementia with Lewy bodies. (20959308)
2010
8
Differential levels of alpha-synuclein, beta-amyloid42 and tau in CSF between patients with dementia with Lewy bodies and Alzheimer's disease. (20522869)
2010
9
Severity of neuropsychiatric symptoms and dopamine transporter levels in dementia with Lewy bodies: a 123I-FP-CIT SPECT study. (19705471)
2009
10
Association of glucocerebrosidase mutations with dementia with lewy bodies. (19433657)
2009
11
Detection of elevated levels of soluble alpha-synuclein oligomers in post-mortem brain extracts from patients with dementia with Lewy bodies. (19155272)
2009
12
Efficacy and safety of memantine in Lewy body dementia. (19517247)
2009
13
CSF alpha-synuclein levels in dementia with Lewy bodies and Alzheimer's disease. (19071095)
2009
14
Memory impairment in elderly patients with dementia with lewy bodies: more than one pattern? (19470019)
2009
15
Early discriminatory diagnosis of dementia with Lewy bodies. The emerging role of CSF and imaging biomarkers. (18204253)
2008
16
Cardiovascular autonomic dysfunction in dementia with Lewy bodies and Parkinson's disease. (17306830)
2007
17
Loss of Musashi1 in Lewy body dementia associated with cholinergic deficit. (17573814)
2007
18
Sensitivity and specificity of dopamine transporter imaging with 123I-FP-CIT SPECT in dementia with Lewy bodies: a phase III, multicentre study. (17362834)
2007
19
Dementia with Lewy bodies in an elderly Greek male due to alpha-synuclein gene mutation. (17049244)
2006
20
Lewy body disease: thalamic cholinergic activity related to dementia and parkinsonism. (15913843)
2006
21
Recurrent spontaneous "neuroleptic malignant syndrome" in the absence of neuroleptic medication in probable dementia with Lewy bodies. (15765193)
2005
22
Impaired metabotropic glutamate receptor/phospholipase C signaling pathway in the cerebral cortex in Alzheimer's disease and dementia with Lewy bodies correlates with stage of Alzheimer's-disease-related changes. (15949941)
2005
23
The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia. (14755719)
2004
24
SNCA multiplication is not a common cause of Parkinson disease or dementia with Lewy bodies. (15304594)
2004
25
Immunohistochemical study of the expression of cytokines and nitric oxide synthases in brains of patients with dementia with Lewy bodies. (12722921)
2003
26
Muscarinic receptors in basal ganglia in dementia with Lewy bodies, Parkinson's disease and Alzheimer's disease. (12706204)
2003
27
Cerebrospinal fluid markers in dementia with lewy bodies compared with Alzheimer disease. (12975286)
2003
28
Butyrylcholinesterase and progression of cognitive deficits in dementia with Lewy bodies. (12796550)
2003
29
Coma with accidental single dose of an atypical neuroleptic in a patient with Lewy Body dementia. (12527549)
2003
30
Lewy body dementia: case report and discussion. (11841138)
2002
31
Differentiating between lewy body dementia and Alzheimer's disease: a retrospective brain bank study. (12812570)
2001
32
The pathology of REM sleep behavior disorder with comorbid Lewy body dementia. (11113232)
2000
33
Clinical Lewy body dementia and the impact of vascular components. (10637403)
2000
34
Vascular dementia presenting as Lewy-body dementia. (11037030)
2000
35
Blood pressure and drug treatment in clinically diagnosed Lewy body dementia and Alzheimer's disease. (15374047)
2000
36
The CCTTT polymorphism in the NOS2A gene is associated with dementia with Lewy bodies. (10674474)
2000
37
Parkinson's disease, dementia with Lewy bodies, multiple system atrophy and alpha-synuclein]. (10791099)
1999
38
Cellular co-localization of phosphorylated tau- and NACP/alpha-synuclein-epitopes in lewy bodies in sporadic Parkinson's disease and in dementia with Lewy bodies. (10528110)
1999
39
Alzheimer's disease pathology in motor cortex in dementia with Lewy bodies clinically mimicking corticobasal degeneration. (10483792)
1999
40
Fatal attractions: abnormal protein aggregation and neuron death in Parkinson's disease and Lewy body dementia. (10203692)
1998
41
Distinguishing Lewy body dementia. (9484298)
1998
42
Mutation in the alpha-synuclein gene and sporadic Parkinson's disease, Alzheimer's disease, and dementia with lewy bodies. (9743579)
1998
43
Pathological lesions of Alzheimer's disease and dementia with Lewy bodies brains exhibit immunoreactivity to an ATPase that is a regulatory subunit of the 26S proteasome. (8971806)
1996
44
Baclofen therapy for rigidity associated with Lewy body dementia. (8968647)
1996
45
Amyloid precursor protein accumulation in Lewy body dementia and Alzheimer's disease. (7606281)
1995
46
Abnormally phosphorylated tau protein in senile dementia of Lewy body type and Alzheimer disease: evidence that the disorders are distinct. (8749611)
1995
47
Lewy body dementia--diagnosis and treatment. (8829735)
1995
48
Alzheimer's disease and Lewy body dementia. (8155133)
1993
49
Evidence of a monoaminergic-cholinergic imbalance related to visual hallucinations in Lewy body dementia. (1697897)
1990
50
Senile dementia of Lewy body type. A clinically and neuropathologically distinct form of Lewy body dementia in the elderly. (2157823)
1990

Genetic Variations for Lewy Body Dementia

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Lewy Body Dementia:

62
id Symbol AA change Variation ID SNP ID
1SNCAp.Glu46LysVAR_022703
2SNCAp.Glu46LysVAR_022703

Expression for genes affiliated with Lewy Body Dementia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lewy Body Dementia

Search GEO for disease gene expression data for Lewy Body Dementia.

Pathways for genes affiliated with Lewy Body Dementia

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49PharmGKB, 37NCBI BioSystems Database, 53Reactome, 4Cell Signaling Technology, 29KEGG
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Compounds for genes affiliated with Lewy Body Dementia

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44Novoseek, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 49PharmGKB, 24HMDB
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Compounds related to Lewy Body Dementia according to GeneCards/GeneDecks:

(show top 50)    (show all 168)
idCompoundScoreTop Affiliating Genes
1phenserine44 5911.4APP, BCHE, ACHE
2ddvp4410.4APP, BCHE, ACHE
3rivastigmine44 1111.4ACHE, APOE, BCHE
4thioflavin t4410.4SNCA, APP, APOE
5chlorpyrifos4410.4ACHE, CHAT, BCHE
6huperzine a4410.3CHAT, ACHE, BCHE, APP
7thioflavine s4410.3RPS27A, SNCA, APOE, APP
8physostigmine44 1111.3APP, ACHE, BCHE, CHAT
9metrifonate4410.3APOE, ACHE, BCHE, APP
10carbamate4410.3ACHE, BCHE, CHAT
11tacrine44 1111.3APP, ACHE, BCHE, APOE
123,4-Methylenedioxymethamphetamine1110.3SLC6A3, SLC18A2, HTR2A
13selegiline44 1111.3SNCA, SLC6A3, BCHE, ACHE
14MMDA1110.3SLC6A3, SLC18A2, HTR2A
15formate4410.3SNCA, RPS27A, APP, APOE
16apomorphine44 28 1112.3SLC6A3, CHAT, HTR2A, SNCA
17duloxetine44 49 28 1113.2SLC18A2, SLC6A3, HTR2A
18pyridostigmine44 1111.2ACHE, CHAT, BCHE
19ephedrine28 44 1112.2ACHE, SLC6A3, SLC18A2, BCHE
20risperidone28 44 49 59 11 2415.2APP, HTR2A, CHAT, SLC6A3
21rasagiline44 1111.2APP, ACHE, BCHE
22galantamine44 49 1112.2APP, CHRNA4, ACHE, BCHE, APOE
236-hydroxydopamine4410.2SNCA, APP, CHAT, SLC6A3, RPS27A
244-hydroxynonenal44 2411.2APP, APOE, SNCA, CHAT, RPS27A
25escitalopram44 49 11 2413.1SLC6A3, HTR2A, SLC18A2
26atropine44 28 1112.1BCHE, ACHE, SNCA, APP
27olanzapine49 44 28 11 2414.1SLC6A3, CHAT, APOE, HTR2A
28mptp4410.1RPS27A, SLC6A3, SNCA, SLC18A2
29methamphetamine44 49 1112.1SLC18A2, CHAT, RPS27A, SNCA, SLC6A3
30donepezil44 11 2412.0ACHE, BCHE, CHAT, APOE, APP, HTR2A
31choline44 11 2412.0BCHE, ACHE, APP, CHAT, SNCA, SLC6A3
32cocaine44 1111.0SNCA, BCHE, SLC18A2, SLC6A3, CHAT
33imipramine44 49 28 11 2414.0HTR2A, CHAT, SLC18A2, SLC6A3
345-hydroxytryptamine4410.0SLC18A2, SLC6A3, CHAT, APP, HTR2A
35valine4410.0SLC6A3, RPS27A, APP, APOE, SNCA
36piperidine449.9ACHE, SLC18A2, SLC6A3
37aspirin44 49 28 2412.8APOE, BCHE, RPS27A, APP, GBA
38nmda44 2810.8SLC6A3, APP, APOE, CHAT, ACHE, BCHE
39levodopa44 1110.8RPS27A, SLC6A3, SLC18A2, SNCA
40norepinephrine44 11 2411.8SNCA, SLC18A2, BCHE, HTR2A, APP, SLC6A3
41h2o2449.7SLC6A3, RPS27A, SNCB, SNCA, APOE, APP
42scopolamine44 28 11 2412.7CHAT, BCHE, ACHE
43nicotine44 49 28 1112.7ACHE, CHRNA4, SLC6A3, SLC18A2, BCHE, APOE
44iron44 2410.6SNCA, SLC18A2, SNCG, SNCB, APP, NDUFB11
45aspartate449.6SLC18A2, RPS27A, APP, BCHE, SLC6A3, APOE
46gaba449.5RPS27A, CHAT, SLC6A3, SLC18A2, APP
47glutamate449.5RPS27A, SNCA, CHAT, APOE, SLC6A3, SLC18A2
48acetylcholine44 49 28 11 2413.4SLC6A3, CHRNA4, APP, RPS27A, APOE, SNCA
49dopamine44 28 11 2412.3SNCA, RPS27A, APP, APOE, HTR2A, CHAT
50serine449.1SNCA, APOE, APP, CHRNA4, RPS27A, SLC6A3

GO Terms for genes affiliated with Lewy Body Dementia

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16Gene Ontology
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Cellular components related to Lewy Body Dementia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1terminal boutonGO:0431959.9SNCB, SNCA, SLC18A2
2perinuclear region of cytoplasmGO:0484719.7SNCG, SNCA, ACHE, TPPP, APP
3axonGO:0304249.6HTR2A, APP, SNCA, CHAT, SLC6A3, ACHE
4neuronal cell bodyGO:0430259.4SLC18A2, APOE, SNCB, SNCG, CHAT, CHRNA4
5plasma membraneGO:0058868.3RPS27A, HTR2A, APP, APOE, SNCG, SNCA

Biological processes related to Lewy Body Dementia according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1neurotransmitter biosynthetic processGO:04213610.3ACHE, SLC6A3, CHAT
2choline metabolic processGO:01969510.2BCHE, ACHE
3synapse organizationGO:05080810.2SNCB, SNCG, SNCA
4adult locomotory behaviorGO:00834410.2SNCA, SNCG, APP
5synaptic transmission, cholinergicGO:00727110.1APOE, CHRNA4, ACHE, BCHE
6regulation of dopamine secretionGO:01405910.1CHRNA4, SNCA, SNCG, HTR2A
7response to cocaineGO:04222010.1SLC18A2, SLC6A3, SNCG
8monoamine transportGO:01584410.1SLC18A2, SLC6A3
9negative regulation of neuron apoptotic processGO:04352410.1SNCA, SNCB, APOE
10dopamine biosynthetic processGO:04241610.1SNCA, SLC6A3
11locomotory behaviorGO:00762610.0APP, CHRNA4, SLC6A3, SLC18A2
12cell deathGO:00821910.0HTR2A, APOE, GBA, SLC6A3
13agingGO:0075689.9HTR2A, APOE, SNCA, SLC6A3, SLC18A2
14response to drugGO:0424939.5SLC6A3, SNCA, SNCG, HTR2A
15synaptic transmissionGO:0072689.5HTR2A, SNCB, SNCG, CHAT, CHRNA4, SLC6A3

Molecular functions related to Lewy Body Dementia according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1acetylcholinesterase activityGO:00399010.3ACHE, BCHE
2cholinesterase activityGO:00410410.2ACHE, BCHE
3alpha-tubulin bindingGO:04301410.2SNCA, SNCG, SNCB
4beta-amyloid bindingGO:00154010.2BCHE, ACHE, APOE
5acetylcholine bindingGO:04216610.2ACHE, CHRNA4
6beta-tubulin bindingGO:04848710.2SNCA, SNCG, SNCB
7monoamine transmembrane transporter activityGO:00850410.1SLC18A2, SLC6A3
8tau protein bindingGO:0481569.9SNCA, APOE
9drug bindingGO:0081449.8HTR2A, SLC6A3, SLC18A2

Products for genes affiliated with Lewy Body Dementia

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Sources for Lewy Body Dementia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet