DLB
MCID: LWY001
MIFTS: 65

Lewy Body Dementia (DLB) malady

Summaries for Lewy Body Dementia

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42NIH Rare Diseases, 33MedlinePlus, 43NINDS, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Lewy body disease is one of the most common causes of dementia in the elderly. dementia is the loss of mental functions severe enough to affect normal activities and relationships. lewy body disease happens when abnormal structures, called lewy bodies, build up in areas of the brain. the disease may cause a wide range of symptoms, including changes in alertness and attention hallucinations problems with movement and posture muscle stiffness confusion loss of memory lewy body disease can be hard to diagnose, because parkinson's disease and alzheimer's disease cause similar symptoms. scientists think that lewy body disease might be related to these diseases, or that they sometimes happen together. lewy body disease usually begins between the ages of 50 and 85. the disease gets worse over time. there is no cure. treatment focuses on drugs to help symptoms. nih: national institute of neurological disorders and stroke

MalaCards: Lewy Body Dementia, also known as lewy body disease, is related to dementia and alzheimer's disease. An important gene associated with Lewy Body Dementia is SNCB (synuclein, beta), and among its related pathways are Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction) and Acetylcholine Synthesis. The compounds phenserine and ddvp have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and testes, and related mouse phenotypes are taste/olfaction and no phenotypic analysis.

NIH Rare Diseases:42 Lewy bodies dementia is one of the most common types of dementia. the central feature of this condition is progressive cognitive decline, combined with three additional defining features: (1) fluctuations in alertness and attention, such as frequent drowsiness, lethargy, lengthy periods of time spent staring into space, or disorganized speech; (2) recurrent visual hallucinations, and (3) parkinsonian motor symptoms, such as rigidity and the loss of spontaneous movement. although the exact cause of this condition is unknown, symptoms result from the build-up of abnormal structures, called lewy bodies, inside the brain. this condition usually occurs sporadically, in people with no known family history of the disease. however, rare familial cases have been reported. last updated: 1/12/2012

NINDS:43 Is one of the most common types of progressive dementia. The central features of DLB include progressive cognitive decline, ?fluctuations? in alertness and attention, visual hallucinations, and parkinsonian motor symptoms, such as slowness of movement, difficulty walking, or rigidity.

Wikipedia:63 Dementia with Lewy bodies (DLB), also known under a variety of other names including Lewy body dementia,... more...

Description from OMIM:46 127750

Aliases & Classifications for Lewy Body Dementia

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8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 22GTR, 43NINDS, 46OMIM, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH
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Aliases & Descriptions:

lewy body dementia 8 42 43 46 10
lewy body disease 8 42 44 33 60
dementia, lewy body 9 22 46
autosomal dominant diffuse lewy body disease 42 60
dementia with lewy bodies 8 43
diffuse lewy body disease 8 42
senile dementia of the lewy body type 8
dlb 42


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Disease Ontology8 DOID:12217
NCIt39 C84826
OMIM46 127750
ICD9CM27 331.82
MeSH34 D020961

Related Diseases for Lewy Body Dementia

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17GeneCards, 18GeneDecks
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Diseases related to Lewy Body Dementia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 101)
idRelated DiseaseScoreTop Affiliating Genes
1dementia31.8BCHE, ACHE, SLC6A3, GBA, CHAT, SNCA
2alzheimer's disease31.3RPS27A, HTR2A, APP, APOE, SNCB, SNCG
3parkinson's disease31.1BCHE, ACHE, SLC18A2, SLC6A3, GBA, CHRNA4
4vascular dementia30.8APOE
5brain disease30.7APP, SNCA, CHAT, BCHE
6frontotemporal dementia30.7RPS27A, APP, APOE, SNCA, ACHE
7multiple system atrophy30.7TPPP, SLC6A3, CHAT, SNCA, SNCG, SNCB
8rem sleep behavior disorder30.4SNCA, SLC6A3
9huntington's disease30.4RPS27A, APP, SNCA, CHAT, SLC6A3, ACHE
10multiple sclerosis30.3APOE
11cerebral amyloid angiopathy30.3APOE, APP
12striatonigral degeneration30.3RPS27A, SNCA, SLC6A3
13progressive supranuclear palsy30.3APOE, SLC6A3
14neuroaxonal dystrophy30.3RPS27A, SNCA
15amyotrophic lateral sclerosis30.3SLC6A3, CHAT, SNCA, APP, RPS27A
16movement disease30.3RPS27A, SNCG, SNCA, SLC6A3, SLC18A2
17pick's disease30.3RPS27A, APP, APOE, SNCA, CHAT, ACHE
18prion disease30.2RPS27A, APP, APOE, SNCA, CHAT, SLC6A3
19tauopathy30.2RPS27A, APP, SNCA
20cerebrovascular disease30.2ACHE, SLC6A3, APOE, APP
21hyperhomocysteinemia30.2BCHE, APOE
22schizophrenia30.2HTR2A, SNCA, CHAT, CHRNA4, SLC6A3, SLC18A2
23psychotic disorder30.1HTR2A, SLC6A3, ACHE
24neuroleptic malignant syndrome10.5
25vascular disease10.4
26capgras syndrome10.4
27neuronitis10.3
28sleep disorder10.3
29relapsing polychondritis10.2
30schizoaffective disorder10.2
31cortical blindness10.2
32aphasia10.2
33basal ganglia disease10.2
34cerebral degeneration10.2
35nervous system disease10.2
36lateral sclerosis10.2
37eye disease10.2
38bruxism10.2
39parametritis10.2
40cerebritis10.2
41skin disease10.2
42tuberculosis10.2
43thalamic disease10.1
44submandibular gland disease10.1
45anxiety disorder10.1
46degenerative nerve diseases10.1
47neuroblastoma10.0CHAT
48hydrocephalus10.0GBA
49hereditary cerebral amyloid angiopathy10.0APP
50gaucher's disease10.0GBA

Graphical network of the top 20 diseases related to Lewy Body Dementia:



Diseases related to lewy body dementia

Clinical Features for Lewy Body Dementia

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46OMIM
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Clinical features from OMIM:

127750

Clinical synopsis from OMIM:

127750

Drugs & Therapeutics for Lewy Body Dementia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Lewy Body Dementia

Drug clinical trials:

Search ClinicalTrials for Lewy Body Dementia

Search NIH Clinical Center for Lewy Body Dementia

Search CenterWatch for Lewy Body Dementia

Genetic Tests for Lewy Body Dementia

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22GTR
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Genetic tests related to Lewy Body Dementia:

id Genetic test Affiliating Genes
1 Lewy Body Dementia22

Anatomical Context for Lewy Body Dementia

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32MalaCards
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MalaCards organs/tissues related to Lewy Body Dementia:

32
Brain, Cortex, Testes, Heart, Skin, Eye, T cells, Temporal lobe

Animal Models for Lewy Body Dementia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Lewy Body Dementia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539410.2SLC6A3, SNCA
2MP:00030129.7APOE, SNCB, SNCA, CHRNA4, ACHE, APP
3MP:00053699.3HTR2A, APP, APOE, CHAT, SLC6A3, SLC18A2
4MP:00036318.8SNCA, SNCG, SNCB, APOE, APP, ATP13A2
5MP:00053868.8ACHE, HTR2A, APP, APOE, SNCG, SNCA
6MP:00053768.7SNCA, SNCG, SNCB, APOE, APP, CHAT
7MP:00107688.6APP, APOE, SNCB, SNCA, CHAT, CHRNA4

Publications for Lewy Body Dementia

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50PubMed
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Articles related to Lewy Body Dementia:

(show top 50)    (show all 344)
idTitleAuthorsYear
1
Clinical features of dementia with lewy bodies in 35 Chinese patients. (24398160)
2014
2
Logopenic progressive aphasia beyond Alzheimer's--an evolution towards dementia with Lewy bodies. (22967721)
2013
3
Sympathetic skin response and heart rate variability as diagnostic tools for the differential diagnosis of Lewy body dementia and Alzheimer's disease: a diagnostic test study. (23457321)
2013
4
Post mortem cerebrospinal fluid I+-synuclein levels are raised in multiple system atrophy and distinguish this from the other I+-synucleinopathies, Parkinson's disease and Dementia with Lewy bodies. (21856424)
2012
5
Finding hope in the midst of despair: my decade with Parkinson's disease and Lewy body dementia. (22890610)
2012
6
Cognitive and structural magnetic resonance imaging features of Lewy body dementia and Alzheimer's disease. (22546353)
2012
7
Clinical and pathological examples of Alzheimer's disease, dementia with Lewy bodies, and frontotemporal dementia. (22928231)
2012
8
Distinct mechanisms of axonal globule formation in mice expressing human wild type I+-synuclein or dementia with Lewy bodies-linked P123H I^-synuclein. (23013868)
2012
9
The impact of autonomic dysfunction on survival in patients with dementia with Lewy bodies and Parkinson's disease with dementia. (23049679)
2012
10
alpha-Synuclein antibodies recognize a protein present at lower levels in the CSF of patients with dementia with Lewy bodies. (19747426)
2010
11
Cerebrospinal fluid beta-glucocerebrosidase activity is reduced in Dementia with Lewy Bodies. (19303930)
2009
12
Cellular glutathione peroxidase in human brain: cellular distribution, and its potential role in the degradation of Lewy bodies in Parkinson's disease and dementia with Lewy bodies. (18853169)
2009
13
Brain insulin-like growth factor and neurotrophin resistance in Parkinson's disease and dementia with Lewy bodies: potential role of manganese neurotoxicity. (19276553)
2009
14
Creutzfeldt-jakob, Parkinson, lewy body dementia and Alzheimer diseases: from diagnosis to therapy. (20021333)
2009
15
Early-onset familial lewy body dementia with extensive tauopathy: a clinical, genetic, and neuropathological study. (19104444)
2009
16
Neuropsychological characteristics of dementia with Lewy bodies and Parkinson's disease with dementia: differentiation, early detection, and implications for "mild cognitive impairment" and biomarkers. (18322801)
2008
17
Lewy body dementia and Parkinson's disease with dementia. (18787881)
2008
18
Association between progranulin and beta-amyloid in dementia with Lewy bodies. (18955727)
2008
19
Plasma and CSF serpins in Alzheimer disease and dementia with Lewy bodies. (17761554)
2007
20
Lewy body dementia and Parkinson disease dementia]. (17572053)
2007
21
Rostral raphe involvement in Lewy body dementia and multiple system atrophy. (17639427)
2007
22
Reduced ubiquitin C-terminal hydrolase-1 expression levels in dementia with Lewy bodies. (16380264)
2006
23
Interaction between Abeta peptide and alpha synuclein: molecular mechanisms in overlapping pathology of Alzheimer's and Parkinson's in dementia with Lewy body disease. (16947080)
2006
24
Clinical and biochemical correlates of insoluble alpha-synuclein in dementia with Lewy bodies. (16482476)
2006
25
CSF orexin levels of Parkinson's disease, dementia with Lewy bodies, progressive supranuclear palsy and corticobasal degeneration. (17005202)
2006
26
Thalamic nicotinic receptors implicated in disturbed consciousness in dementia with Lewy bodies. (16023355)
2006
27
Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the Consortium on DLB International Workshop. (16914880)
2006
28
Correlation of entorhinal amyloid with memory in Alzheimer's and vascular but not Lewy body dementia. (15572872)
2005
29
Normal CSF hypocretin-1 (orexin A) levels in dementia with Lewy bodies associated with excessive daytime sleepiness. (15256827)
2004
30
Lewy body dementia: the litmus test for neuroleptic sensitivity and extrapyramidal symptoms. (15264967)
2004
31
Striatal monoamine terminals in Lewy body dementia and Alzheimer's disease. (15174011)
2004
32
Cycles of aberrant synaptic sprouting and neurodegeneration in Alzheimer's and dementia with Lewy bodies. (14584828)
2003
33
Patterns of cerebral atrophy in dementia with Lewy bodies using voxel-based morphometry. (12377138)
2002
34
Capgras' syndrome in dementia with Lewy bodies. (12489921)
2002
35
Distribution of m1 muscarinic acetylcholine receptors in the hippocampus of patients with Alzheimer's disease and dementia with Lewy bodies-an immunohistochemical study. (11718746)
2001
36
Cortical neurons expressing calcium binding proteins are spared in dementia with Lewy bodies. (11194939)
2001
37
No evidence of an association between CYP2D6 polymorphisms among Japanese and dementia with Lewy bodies. (11285084)
2001
38
Active, phosphorylation-dependent mitogen-activated protein kinase (MAPK/ERK), stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK), and p38 kinase expression in Parkinson's disease and Dementia with Lewy bodies. (11810403)
2001
39
Acetylcholinesterase inhibition in dementia with Lewy bodies: results of a prospective pilot trial. (11044776)
2000
40
Lewy body dementia. (10442673)
1999
41
Combination of risperidone and donepezil in Lewy body dementia. (9598283)
1998
42
Immunoelectron-microscopic demonstration of NACP/alpha-synuclein-epitopes on the filamentous component of Lewy bodies in Parkinson's disease and in dementia with Lewy bodies. (9795161)
1998
43
Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies. (9546347)
1998
44
Dementia with Lewy bodies versus pure Alzheimer disease: differences in cognition, neuropathology, cholinergic dysfunction, and synapse density. (9143263)
1997
45
Indices of oxidative stress in Parkinson's disease, Alzheimer's disease and dementia with Lewy bodies. (9470137)
1997
46
Motor and cognitive function in Lewy body dementia: comparison with Alzheimer's and Parkinson's diseases. (9069479)
1997
47
Cytoskeletal pathology in non-Alzheimer degenerative dementia: new lesions in diffuse Lewy body disease, Pick's disease, and corticobasal degeneration. (8841955)
1996
48
Monoaminergic activities in Lewy body dementia: relation to hallucinosis and extrapyramidal features. (8123190)
1993
49
Cholinergic transmitter and neurotrophic activities in Lewy body dementia: similarity to Parkinson's and distinction from Alzheimer disease. (8347330)
1993
50
Neocortical concentrations of neuropeptides in senile dementia of the Alzheimer and Lewy body type: comparison with Parkinson's disease and severity correlations. (1674664)
1991

Genetic Variations for Lewy Body Dementia

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Lewy Body Dementia:

62
id Symbol AA change Variation ID SNP ID
1SNCAp.Glu46LysVAR_022703
2SNCAp.Glu46LysVAR_022703

Expression for genes affiliated with Lewy Body Dementia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lewy Body Dementia

Search GEO for disease gene expression data for Lewy Body Dementia.

Pathways for genes affiliated with Lewy Body Dementia

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49PharmGKB, 37NCBI BioSystems Database, 53Reactome, 4Cell Signaling Technology, 29KEGG
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Compounds for genes affiliated with Lewy Body Dementia

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44Novoseek, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 49PharmGKB, 24HMDB
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Compounds related to Lewy Body Dementia according to GeneCards/GeneDecks:

(show top 50)    (show all 168)
idCompoundScoreTop Affiliating Genes
1phenserine44 5911.4APP, ACHE, BCHE
2ddvp4410.4APP, ACHE, BCHE
3rivastigmine44 1111.4BCHE, ACHE, APOE
4thioflavin t4410.4SNCA, APOE, APP
5chlorpyrifos4410.4BCHE, ACHE, CHAT
6huperzine a4410.3APP, CHAT, ACHE, BCHE
7thioflavine s4410.3RPS27A, APP, APOE, SNCA
8physostigmine44 1111.3APP, CHAT, ACHE, BCHE
9metrifonate4410.3BCHE, ACHE, APOE, APP
10carbamate4410.3BCHE, ACHE, CHAT
11tacrine44 1111.3APP, APOE, ACHE, BCHE
123,4-Methylenedioxymethamphetamine1110.3HTR2A, SLC6A3, SLC18A2
13selegiline44 1111.3SNCA, SLC6A3, ACHE, BCHE
14MMDA1110.3SLC18A2, SLC6A3, HTR2A
15formate4410.3SNCA, APOE, APP, RPS27A
16apomorphine44 28 1112.3HTR2A, SNCA, CHAT, SLC6A3
17duloxetine44 49 28 1113.2HTR2A, SLC6A3, SLC18A2
18pyridostigmine44 1111.2BCHE, ACHE, CHAT
19ephedrine28 44 1112.2BCHE, ACHE, SLC18A2, SLC6A3
20risperidone28 44 49 59 11 2415.2SLC6A3, CHAT, APP, HTR2A
21rasagiline44 1111.2APP, ACHE, BCHE
22galantamine44 49 1112.2APP, APOE, CHRNA4, ACHE, BCHE
236-hydroxydopamine4410.2RPS27A, APP, SNCA, CHAT, SLC6A3
244-hydroxynonenal44 2411.2CHAT, SNCA, APOE, APP, RPS27A
25escitalopram44 49 11 2413.1SLC18A2, SLC6A3, HTR2A
26atropine44 28 1112.1APP, SNCA, ACHE, BCHE
27olanzapine49 44 28 11 2414.1HTR2A, APOE, CHAT, SLC6A3
28mptp4410.1RPS27A, SNCA, SLC6A3, SLC18A2
29methamphetamine44 49 1112.1SLC18A2, SLC6A3, CHAT, SNCA, RPS27A
30donepezil44 11 2412.0BCHE, HTR2A, APP, APOE, CHAT, ACHE
31choline44 11 2412.0APP, SNCA, CHAT, SLC6A3, ACHE, BCHE
32cocaine44 1111.0SNCA, CHAT, SLC6A3, SLC18A2, BCHE
33imipramine44 49 28 11 2414.0HTR2A, CHAT, SLC6A3, SLC18A2
345-hydroxytryptamine4410.0HTR2A, APP, CHAT, SLC6A3, SLC18A2
35valine4410.0SLC6A3, SNCA, APOE, APP, RPS27A
36piperidine449.9SLC6A3, SLC18A2, ACHE
37aspirin44 49 28 2412.8RPS27A, APP, APOE, GBA, BCHE
38nmda44 2810.8RPS27A, APP, APOE, CHAT, SLC6A3, ACHE
39levodopa44 1110.8SLC18A2, SLC6A3, SNCA, RPS27A
40norepinephrine44 11 2411.8HTR2A, APP, SNCA, CHAT, SLC6A3, SLC18A2
41h2o2449.7RPS27A, APP, APOE, SNCB, SNCA, SLC6A3
42scopolamine44 28 11 2412.7CHAT, ACHE, BCHE
43nicotine44 49 28 1112.7APP, APOE, CHAT, CHRNA4, SLC6A3, SLC18A2
44iron44 2410.6NDUFB11, APP, SNCB, SNCG, SNCA, SLC18A2
45aspartate449.6RPS27A, APP, APOE, CHAT, DPP7, SLC6A3
46gaba449.5SLC18A2, SLC6A3, CHAT, APP, RPS27A
47glutamate449.5RPS27A, APP, APOE, SNCA, CHAT, SLC6A3
48acetylcholine44 49 28 11 2413.4RPS27A, APP, APOE, SNCA, CHAT, CHRNA4
49dopamine44 28 11 2412.3APOE, APP, HTR2A, RPS27A, SNCA, CHAT
50serine449.1RPS27A, APP, APOE, SNCA, CHRNA4, DPP7

GO Terms for genes affiliated with Lewy Body Dementia

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16Gene Ontology
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Cellular components related to Lewy Body Dementia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1terminal boutonGO:0431959.9SNCB, SNCA, SLC18A2
2perinuclear region of cytoplasmGO:0484719.7SNCG, SNCA, ACHE, TPPP, APP
3axonGO:0304249.6HTR2A, APP, SNCA, CHAT, SLC6A3, ACHE
4neuronal cell bodyGO:0430259.4SLC18A2, APOE, SNCB, SNCG, CHAT, CHRNA4
5plasma membraneGO:0058868.3RPS27A, HTR2A, APP, APOE, SNCG, SNCA

Biological processes related to Lewy Body Dementia according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1neurotransmitter biosynthetic processGO:04213610.3ACHE, SLC6A3, CHAT
2choline metabolic processGO:01969510.2BCHE, ACHE
3synapse organizationGO:05080810.2SNCB, SNCG, SNCA
4adult locomotory behaviorGO:00834410.2SNCA, SNCG, APP
5synaptic transmission, cholinergicGO:00727110.1APOE, CHRNA4, ACHE, BCHE
6regulation of dopamine secretionGO:01405910.1CHRNA4, SNCA, SNCG, HTR2A
7response to cocaineGO:04222010.1SLC18A2, SLC6A3, SNCG
8monoamine transportGO:01584410.1SLC18A2, SLC6A3
9negative regulation of neuron apoptotic processGO:04352410.1SNCA, SNCB, APOE
10dopamine biosynthetic processGO:04241610.1SNCA, SLC6A3
11locomotory behaviorGO:00762610.0APP, CHRNA4, SLC6A3, SLC18A2
12cell deathGO:00821910.0HTR2A, APOE, GBA, SLC6A3
13agingGO:0075689.9HTR2A, APOE, SNCA, SLC6A3, SLC18A2
14response to drugGO:0424939.5SLC6A3, SNCA, SNCG, HTR2A
15synaptic transmissionGO:0072689.5HTR2A, SNCB, SNCG, CHAT, CHRNA4, SLC6A3

Molecular functions related to Lewy Body Dementia according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1acetylcholinesterase activityGO:00399010.3ACHE, BCHE
2cholinesterase activityGO:00410410.2ACHE, BCHE
3alpha-tubulin bindingGO:04301410.2SNCA, SNCG, SNCB
4beta-amyloid bindingGO:00154010.2BCHE, ACHE, APOE
5acetylcholine bindingGO:04216610.2ACHE, CHRNA4
6beta-tubulin bindingGO:04848710.2SNCA, SNCG, SNCB
7monoamine transmembrane transporter activityGO:00850410.1SLC18A2, SLC6A3
8tau protein bindingGO:0481569.9SNCA, APOE
9drug bindingGO:0081449.8HTR2A, SLC6A3, SLC18A2

Products for genes affiliated with Lewy Body Dementia

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  • Antibodies
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Sources for Lewy Body Dementia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet