DLB
MCID: LWY001
MIFTS: 60

Lewy Body Dementia (DLB) malady

Summaries for Lewy Body Dementia

Sources:
43NIH Rare Diseases, 34MedlinePlus, 44NINDS, 64Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 Lewy body disease is one of the most common causes of dementia in the elderly. dementia is the loss of mental functions severe enough to affect normal activities and relationships. lewy body disease happens when abnormal structures, called lewy bodies, build up in areas of the brain. the disease may cause a wide range of symptoms, including changes in alertness and attention hallucinations problems with movement and posture muscle stiffness confusion loss of memory lewy body disease can be hard to diagnose, because parkinson's disease and alzheimer's disease cause similar symptoms. scientists think that lewy body disease might be related to these diseases, or that they sometimes happen together. lewy body disease usually begins between the ages of 50 and 85. the disease gets worse over time. there is no cure. treatment focuses on drugs to help symptoms. nih: national institute of neurological disorders and stroke

MalaCards: Lewy Body Dementia, also known as lewy body disease, is related to alzheimer's disease and parkinson's disease. An important gene associated with Lewy Body Dementia is SNCB (synuclein, beta), and among its related pathways are Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction) and Acetylcholine Synthesis. The compounds phenserine and ddvp have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and heart, and related mouse phenotypes are taste/olfaction and no phenotypic analysis.

NIH Rare Diseases:43 Lewy bodies dementia is one of the most common types of dementia. the central feature of this condition is progressive cognitive decline, combined with three additional defining features: (1) fluctuations in alertness and attention, such as frequent drowsiness, lethargy, lengthy periods of time spent staring into space, or disorganized speech; (2) recurrent visual hallucinations, and (3) parkinsonian motor symptoms, such as rigidity and the loss of spontaneous movement. although the exact cause of this condition is unknown, symptoms result from the build-up of abnormal structures, called lewy bodies, inside the brain. this condition usually occurs sporadically, in people with no known family history of the disease. however, rare familial cases have been reported. last updated: 1/12/2012

NINDS:44 Is one of the most common types of progressive dementia. The central feature of DLB is progressive cognitive decline, combined with three additional defining features:

Wikipedia:64 Dementia with Lewy bodies (DLB), also known under a variety of other names including Lewy body dementia,... more...

Description from OMIM:47 127750

Aliases & Classifications for Lewy Body Dementia

Sources:
8Disease Ontology, 9diseasecard, 43NIH Rare Diseases, 22GTR, 44NINDS, 47OMIM, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 40NCIt, 27ICD9CM, 35MeSH
See all sources

Aliases & Descriptions:

lewy body dementia 8 43 44 47 10
lewy body disease 8 43 45 34 61
dementia, lewy body 9 22 47
autosomal dominant diffuse lewy body disease 43 61
dementia with lewy bodies 8 44
diffuse lewy body disease 8 43
senile dementia of the lewy body type 8
dlb 43


External Ids:

Disease Ontology8 DOID:12217
NCIt40 C84826
OMIM47 127750
ICD9CM27 331.82
MeSH35 D020961

Related Diseases for Lewy Body Dementia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Lewy Body Dementia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 122)
idRelated DiseaseScoreTop Affiliating Genes
1alzheimer's disease31.1RPS27A, HTR2A, APP, APOE, SNCB, SNCG
2parkinson's disease30.9BCHE, ACHE, SLC18A2, SLC6A3, GBA, CHRNA4
3vascular dementia30.8APOE
4frontotemporal dementia30.8RPS27A, APP, APOE, SNCA, ACHE
5brain disease30.7APP, SNCA, CHAT, BCHE
6pick's disease30.6RPS27A, APP, APOE, SNCA, CHAT, ACHE
7cerebral amyloid angiopathy30.3APOE, APP
8striatonigral degeneration30.3RPS27A, SNCA, SLC6A3
9memory impairment30.3BCHE, ACHE, SLC6A3, CHAT, SNCA, APOE
10progressive supranuclear palsy30.3APOE, SLC6A3
11neuroaxonal dystrophy30.3RPS27A, SNCA
12amyotrophic lateral sclerosis30.3SLC6A3, CHAT, SNCA, APP, RPS27A
13gaucher's disease30.3GBA
14tauopathy30.3RPS27A, APP, SNCA
15hyperhomocysteinemia30.3BCHE, APOE
16pure autonomic failure30.1SNCA, ACHE
17neuroleptic malignant syndrome10.5
18n syndrome10.5
19vascular disease10.4
20capgras syndrome10.4
21cerebral atrophy10.4
22posterior cortical atrophy10.4
23sleep disorder10.3
24dementia - subcortical10.3
25dysphagia10.3
26autonomic dysfunction10.3
27hemoglobin d disease10.2
28relapsing polychondritis10.2
29schizoaffective disorder10.2
30cortical blindness10.2
31aphasia10.2
32basal ganglia disease10.2
33char syndrome10.2
34charles bonnet syndrome10.2
35logopenic progressive aphasia10.2
36ataxia10.2
37dysautonomia10.2
38myoclonus10.2
39tremor10.2
40parkinson disease 510.2
41parkinson disease 110.2
42alzheimer disease 1210.2
43insulin resistance10.2
44parkinson disease 1210.2
45blindness10.2
46argyrophilic grain disease10.2
47lateral sclerosis10.2
48bod syndrome10.2
49corticobasal degeneration10.2
50progressive supranuclear palsy - corticobasal syndrome10.2

Graphical network of the top 20 diseases related to Lewy Body Dementia:



Diseases related to lewy body dementia

Clinical Features for Lewy Body Dementia

Sources:
47OMIM
See all sources

Clinical features from OMIM:

127750

Clinical synopsis from OMIM:

127750

Drugs & Therapeutics for Lewy Body Dementia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Lewy Body Dementia

Drug clinical trials:

Search ClinicalTrials for Lewy Body Dementia

Search NIH Clinical Center for Lewy Body Dementia

Search CenterWatch for Lewy Body Dementia

Genetic Tests for Lewy Body Dementia

Sources:
22GTR
See all sources

Genetic tests related to Lewy Body Dementia:

id Genetic test Affiliating Genes
1 Lewy Body Dementia22

Anatomical Context for Lewy Body Dementia

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Lewy Body Dementia:

33
Skin, Brain, Heart, T cells, Temporal lobe

Animal Models for Lewy Body Dementia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Lewy Body Dementia

Sources:
51PubMed
See all sources

Articles related to Lewy Body Dementia:

(show top 50)    (show all 146)
idTitleAuthorsYear
1
Intrusion of rapid eye movement (REM) behavior disorder episodes into NREM sleep in a case of Lewy body dementia. (23063303)
2013
2
Dysphagia due to isoniazid therapy for tuberculosis in a patient with Lewy body dementia. (22608343)
2013
3
An effective environmental intervention for management of the 'mirror sign' in a case of probable Lewy body dementia. (22229711)
2013
4
Neuropathological correlates of volumetric MRI in autopsy-confirmed Lewy body dementia. (21353336)
2012
5
No association of COMT val158met polymorphism and psychotic symptoms in Lewy body dementias. (23069674)
2012
6
White matter hyperintensities in mild lewy body dementia. (23189084)
2012
7
The "closing-in" phenomenon in Parkinson's disease dementia and lewy-body dementia. (23224479)
2012
8
Stress and burden among caregivers of patients with Lewy body dementia. (20667944)
2011
9
Lewy body dementia: the caregiver experience of clinical care. (20434939)
2010
10
Lewy body dementia: caregiver burden and unmet needs. (20505434)
2010
11
The CST3 BB genotype and low cystatin C cerebrospinal fluid levels are associated with dementia in Lewy body disease. (20157249)
2010
12
Metabolic alterations associated with impaired clock drawing in Lewy body dementia. (20074912)
2010
13
Motor worsening and tardive dyskinesia with aripiprazole in Lewy body dementia. (21686897)
2009
14
Twin pairs discordant for neuropathologically confirmed Lewy body dementia. (19372291)
2009
15
A friend of mine has been losing her memory and suffering from confusion. She's been diagnosed with a condition called Lewy body dementia. What exactly is this disorder and how does it affect people? (16832887)
2006
16
Rapid loss of striatal VMAT2 binding associated with onset of Lewy body dementia. (16258980)
2006
17
Interaction between Abeta peptide and alpha synuclein: molecular mechanisms in overlapping pathology of Alzheimer's and Parkinson's in dementia with Lewy body disease. (16947080)
2006
18
The contribution of statistical parametric mapping in the assessment of precuneal and medial temporal lobe perfusion by 99mTc-HMPAO SPECT in mild Alzheimer's and Lewy body dementia. (16264357)
2005
19
Correlation of entorhinal amyloid with memory in Alzheimer's and vascular but not Lewy body dementia. (15572872)
2005
20
Striatal monoamine terminals in Lewy body dementia and Alzheimer's disease. (15174011)
2004
21
The nitric oxide synthase-3 codon 298 polymorphism is not associated with late-onset sporadic Alzheimer's dementia and Lewy body disease in a sample from Hungary. (14639046)
2003
22
Electroconvulsive therapy for patients with major depression and probable Lewy body dementia. (12792460)
2003
23
Lewy body dementia. (11989189)
2002
24
Lewy body dementia: case report and discussion. (11841138)
2002
25
Differentiating between lewy body dementia and Alzheimer's disease: a retrospective brain bank study. (12812570)
2001
26
The pathology of REM sleep behavior disorder with comorbid Lewy body dementia. (11113232)
2000
27
Vascular dementia presenting as Lewy-body dementia. (11037030)
2000
28
Blood pressure and drug treatment in clinically diagnosed Lewy body dementia and Alzheimer's disease. (15374047)
2000
29
Lewy body dementia. (10442673)
1999
30
Frontal cortical synaptophysin in Lewy body diseases: relation to Alzheimer's disease and dementia. (9598683)
1998
31
REM sleep behavior disorder and degenerative dementia: an association likely reflecting Lewy body disease. (9710004)
1998
32
Tacrine efficacy in Lewy body dementia. (9733331)
1998
33
Neuropsychological performance in Lewy body dementia and Alzheimer's disease. (9093505)
1997
34
Amyloid beta-peptide and its relationship with dementia in Lewy body disease. (9470134)
1997
35
Apolipoprotein E gene in Parkinson's disease, Lewy body dementia and Alzheimer's disease. (9470136)
1997
36
Lewy body dementia. (9404311)
1997
37
Lewy-body dementia and responsiveness to cholinesterase inhibitors: a paradigm for heterogeneity of Alzheimer's disease? (8984743)
1996
38
Cytoskeletal pathology in non-Alzheimer degenerative dementia: new lesions in diffuse Lewy body disease, Pick's disease, and corticobasal degeneration. (8841955)
1996
39
Effects of apolipoprotein E genotype on cortical neuropathology in senile dementia of the Lewy body and Alzheimer's disease. (8846238)
1995
40
Neuroleptic sensitivity to risperidone in Lewy body dementia. (7544860)
1995
41
Risperidone for psychotic and behavioural symptoms in Lewy body dementia. (7541499)
1995
42
Comparison of cathepsin protease activities in brain tissue from normal cases and cases with Alzheimer's disease, Lewy body dementia, Parkinson's disease and Huntington's disease. (7561949)
1995
43
Senile dementia of the Lewy body type has an apolipoprotein E epsilon 4 allele frequency intermediate between controls and Alzheimer's disease. (7891871)
1994
44
Alzheimer's disease and Lewy body dementia. (8155133)
1993
45
Alzheimer's disease and Lewy body dementia. (8155132)
1993
46
Neocortical concentrations of neuropeptides in senile dementia of the Alzheimer and Lewy body type: comparison with Parkinson's disease and severity correlations. (1674664)
1991
47
Cortical serotonin-S2 receptor binding in Lewy body dementia, Alzheimer's and Parkinson's diseases. (1779239)
1991
48
Evidence of a monoaminergic-cholinergic imbalance related to visual hallucinations in Lewy body dementia. (1697897)
1990
49
Cortical Lewy body dementia: clinical features and classification. (2467966)
1989
50
Clinical and pathological features of diffuse cortical Lewy body disease (Lewy body dementia). (2823957)
1987

Genetic Variations for Lewy Body Dementia

Sources:
63UniProtKB/Swiss-Prot
See all sources

Genetic disease variations for Lewy Body Dementia:

63
id Symbol AA change Variation SNP ID
1SNCAp.Glu46LysVAR_022703

Expression for genes affiliated with Lewy Body Dementia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Lewy Body Dementia

Search GEO for disease gene expression data for Lewy Body Dementia.

Pathways for genes affiliated with Lewy Body Dementia

Sources:
50PharmGKB, 38NCBI BioSystems Database, 54Reactome, 4Cell Signaling Technology, 30KEGG
See all sources

Compounds for genes affiliated with Lewy Body Dementia

Sources:
45Novoseek, 60Tocris Bioscience, 11DrugBank, 29IUPHAR, 50PharmGKB, 24HMDB
See all sources

Compounds related to Lewy Body Dementia according to GeneCards/GeneDecks:

(show top 50)    (show all 168)
idCompoundScoreTop Affiliating Genes
1phenserine45 6011.4APP, BCHE, ACHE
2ddvp4510.4APP, BCHE, ACHE
3rivastigmine45 1111.4ACHE, APOE, BCHE
4thioflavin t4510.4SNCA, APP, APOE
5chlorpyrifos4510.4ACHE, CHAT, BCHE
6huperzine a4510.3CHAT, ACHE, BCHE, APP
7thioflavine s4510.3RPS27A, SNCA, APOE, APP
8physostigmine45 1111.3APP, ACHE, BCHE, CHAT
9metrifonate4510.3APOE, ACHE, BCHE, APP
10carbamate4510.3ACHE, BCHE, CHAT
11tacrine45 1111.3APP, ACHE, BCHE, APOE
123,4-Methylenedioxymethamphetamine1110.3SLC6A3, SLC18A2, HTR2A
13selegiline45 1111.3SNCA, SLC6A3, BCHE, ACHE
14MMDA1110.3SLC6A3, SLC18A2, HTR2A
15formate4510.3SNCA, RPS27A, APP, APOE
16apomorphine45 29 1112.3SLC6A3, CHAT, HTR2A, SNCA
17duloxetine45 50 29 1113.2SLC18A2, SLC6A3, HTR2A
18pyridostigmine45 1111.2ACHE, CHAT, BCHE
19ephedrine29 45 1112.2ACHE, SLC6A3, SLC18A2, BCHE
20risperidone29 45 50 60 11 2415.2APP, HTR2A, CHAT, SLC6A3
21rasagiline45 1111.2APP, ACHE, BCHE
22galantamine45 50 1112.2APP, CHRNA4, ACHE, BCHE, APOE
236-hydroxydopamine4510.2SNCA, APP, CHAT, SLC6A3, RPS27A
244-hydroxynonenal45 2411.2APP, APOE, SNCA, CHAT, RPS27A
25escitalopram45 50 11 2413.1SLC6A3, HTR2A, SLC18A2
26atropine45 29 1112.1BCHE, ACHE, SNCA, APP
27olanzapine50 45 29 11 2414.1SLC6A3, CHAT, APOE, HTR2A
28mptp4510.1RPS27A, SLC6A3, SNCA, SLC18A2
29methamphetamine45 50 1112.1SLC18A2, CHAT, RPS27A, SNCA, SLC6A3
30donepezil45 11 2412.0ACHE, BCHE, CHAT, APOE, APP, HTR2A
31choline45 11 2412.0BCHE, ACHE, APP, CHAT, SNCA, SLC6A3
32cocaine45 1111.0SNCA, BCHE, SLC18A2, SLC6A3, CHAT
33imipramine45 50 29 11 2414.0HTR2A, CHAT, SLC18A2, SLC6A3
345-hydroxytryptamine4510.0SLC18A2, SLC6A3, CHAT, APP, HTR2A
35valine4510.0SLC6A3, RPS27A, APP, APOE, SNCA
36piperidine459.9ACHE, SLC18A2, SLC6A3
37aspirin45 50 29 2412.8APOE, BCHE, RPS27A, APP, GBA
38nmda45 2910.8SLC6A3, APP, APOE, CHAT, ACHE, BCHE
39levodopa45 1110.8RPS27A, SLC6A3, SLC18A2, SNCA
40norepinephrine45 11 2411.8SNCA, SLC18A2, BCHE, HTR2A, APP, SLC6A3
41h2o2459.7SLC6A3, RPS27A, SNCB, SNCA, APOE, APP
42scopolamine45 29 11 2412.7CHAT, BCHE, ACHE
43nicotine45 50 29 1112.7ACHE, CHRNA4, SLC6A3, SLC18A2, BCHE, APOE
44iron45 2410.6SNCA, SLC18A2, SNCG, SNCB, APP, NDUFB11
45aspartate459.6SLC18A2, RPS27A, APP, BCHE, SLC6A3, APOE
46gaba459.5RPS27A, CHAT, SLC6A3, SLC18A2, APP
47glutamate459.5RPS27A, SNCA, CHAT, APOE, SLC6A3, SLC18A2
48acetylcholine45 50 29 11 2413.4SLC6A3, CHRNA4, APP, RPS27A, APOE, SNCA
49dopamine45 29 11 2412.3SNCA, RPS27A, APP, APOE, HTR2A, CHAT
50serine459.1SNCA, APOE, APP, CHRNA4, RPS27A, SLC6A3

GO Terms for genes affiliated with Lewy Body Dementia

Sources:
16Gene Ontology
See all sources

Cellular components related to Lewy Body Dementia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1terminal boutonGO:0431959.9SLC18A2, SNCA, SNCB
2perinuclear region of cytoplasmGO:0484719.7TPPP, ACHE, SNCA, SNCG, APP
3axonGO:0304249.6SLC6A3, CHAT, ACHE, SNCA, HTR2A, APP
4neuronal cell bodyGO:0430259.4CHRNA4, SLC6A3, CHAT, SNCG, SNCB, APOE
5plasma membraneGO:0058868.3TPPP, RPS27A, ACHE, SLC18A2, SLC6A3, CHRNA4

Biological processes related to Lewy Body Dementia according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1neurotransmitter biosynthetic processGO:04213610.3ACHE, SLC6A3, CHAT
2choline metabolic processGO:01969510.2BCHE, ACHE
3synapse organizationGO:05080810.2SNCB, SNCG, SNCA
4adult locomotory behaviorGO:00834410.2SNCA, SNCG, APP
5synaptic transmission, cholinergicGO:00727110.1APOE, CHRNA4, ACHE, BCHE
6regulation of dopamine secretionGO:01405910.1CHRNA4, SNCA, SNCG, HTR2A
7response to cocaineGO:04222010.1SLC18A2, SLC6A3, SNCG
8monoamine transportGO:01584410.1SLC18A2, SLC6A3
9negative regulation of neuron apoptotic processGO:04352410.1SNCA, SNCB, APOE
10dopamine biosynthetic processGO:04241610.1SNCA, SLC6A3
11locomotory behaviorGO:00762610.0APP, CHRNA4, SLC6A3, SLC18A2
12cell deathGO:00821910.0HTR2A, APOE, GBA, SLC6A3
13agingGO:0075689.9HTR2A, APOE, SNCA, SLC6A3, SLC18A2
14response to drugGO:0424939.5SLC6A3, SNCA, SNCG, HTR2A
15synaptic transmissionGO:0072689.5HTR2A, SNCB, SNCG, CHAT, CHRNA4, SLC6A3

Molecular functions related to Lewy Body Dementia according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1acetylcholinesterase activityGO:00399010.3ACHE, BCHE
2cholinesterase activityGO:00410410.2ACHE, BCHE
3alpha-tubulin bindingGO:04301410.2SNCA, SNCG, SNCB
4beta-amyloid bindingGO:00154010.2BCHE, ACHE, APOE
5acetylcholine bindingGO:04216610.2ACHE, CHRNA4
6beta-tubulin bindingGO:04848710.2SNCA, SNCG, SNCB
7monoamine transmembrane transporter activityGO:00850410.1SLC18A2, SLC6A3
8tau protein bindingGO:0481569.9SNCA, APOE
9drug bindingGO:0081449.8HTR2A, SLC6A3, SLC18A2

Products for genes affiliated with Lewy Body Dementia

  • Antibodies
  • Proteins
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  • Antibodies

Sources for Lewy Body Dementia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet