MCID: LYD001
MIFTS: 51

Leydig Cell Tumor malady

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Summaries for Leydig Cell Tumor

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Wikipedia:65 Leydig cell tumour, also Leydig cell tumor (US spelling), (testicular) interstitial cell tumour and... more...

MalaCards based summary: Leydig Cell Tumor, also known as leydig cell neoplasm, is related to sertoli-leydig cell tumor and goiter. An important gene associated with Leydig Cell Tumor is DICER1 (dicer 1, ribonuclease type III), and among its related pathways are Estrone metabolism and Ovarian steroidogenesis. The compounds methoxyresorufin and pf 4981517 have been mentioned in the context of this disorder. Affiliated tissues include testis, ovary and breast, and related mouse phenotypes are skeleton and normal.

Aliases & Classifications for Leydig Cell Tumor

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 34MeSH, 57SNOMED-CT, 39NCIt
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Leydig Cell Tumor, Aliases & Descriptions:

Name: Leydig Cell Tumor 8 10 44 62
 
Leydig Cell Neoplasm 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:2696
MeSH34 D007984
SNOMED-CT57 189739005, 45002009
NCIt39 C3188

Related Diseases for Leydig Cell Tumor

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Diseases in the Leydig Cell Tumor family:

Malignant Leydig Cell Tumor

Diseases related to Leydig Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 95)
idRelated DiseaseScoreTop Affiliating Genes
1sertoli-leydig cell tumor32.2INHA, AFP
2goiter31.1INSL3
3gynecomastia31.1INHA, CYP19A1, CYP17A1
4precocious puberty30.9CYP19A1, CYP21A2
5sertoli cell tumor30.7CYP19A1, INHA
6adrenal rest tumor30.6NR5A1, CYP21A2
7pseudohermaphroditism30.6CYP17A1, CYP19A1
8hyperandrogenism30.6INSL3, CYP21A2, CYP19A1, CYP17A1
9cryptorchidism30.5CYP19A1, INSL3, NR5A1
10dysgerminoma30.5AFP, INHA
1121-hydroxylase deficiency30.5CYP21A2, INHA
12congenital adrenal hyperplasia30.4CYP17A1, NR5A1, CYP19A1, CYP21A2
13adrenal adenoma30.2CYP19A1, CYP21A2, CYP17A1
14endometrial carcinoma30.2CYP17A1, CYP19A1, INHA
15adenoma29.8INHA, NR5A1, CYP21A2, CYP17A1
16choriocarcinoma29.8AFP, INHA, CYP19A1, NR5A1
17klinefelter's syndrome29.8NR5A1, INHA, CYP21A2, CYP19A1
18adenocarcinoma29.7NR5A1, AFP, INHA, CYP21A2
19infertility29.5CYP19A1, CYP21A2, INSL3, INHA, NR5A1
20breast cancer29.3NR5A1, INHA, CYP21A2, CYP19A1, CYP17A1
21testicular leydig cell tumor10.8
22malignant leydig cell tumor10.8
23hypercalcemia10.6
24androgen insensitivity syndrome10.5
25complete androgen insensitivity syndrome10.5
26sarcoma10.5
27cystadenoma10.4
28malignant testicular leydig cell tumor10.4
29multinodular goiter10.4
30humoral hypercalcemia of malignancy10.4
31goiter, multinodular 1, with or without sertoli-leydig cell tumors10.4
32teratoma10.4
33malignant sertoli-leydig cell tumor of ovary10.4
34acute adrenal insufficiency10.4CYP21A2
35premature ovarian failure10.4INHA
36amenorrhea10.3
37malignant sertoli-leydig cell tumor10.3
38cervicitis10.3
39mature teratoma10.3
40rhabdomyosarcoma10.3
41gonadal dysgenesis10.3NR5A1
42endometrial stromal sarcoma10.3CYP19A1, INHA
43adrenocortical carcinoma10.3NR5A1
44aorta atresia10.2CYP19A1, INHA
45endodermal sinus tumor10.2INHA, AFP
46peutz-jeghers syndrome10.2INHA, CYP19A1
47androgenetic alopecia10.2CYP19A1, CYP21A2
48anovulation10.2CYP19A1, CYP21A2
49hematopoietic stem cell transplantation10.2
50islet cell tumor10.2

Graphical network of the top 20 diseases related to Leydig Cell Tumor:



Diseases related to leydig cell tumor

Symptoms for Leydig Cell Tumor

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Drugs & Therapeutics for Leydig Cell Tumor

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Drug clinical trials:

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Search NIH Clinical Center for Leydig Cell Tumor

Genetic Tests for Leydig Cell Tumor

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Anatomical Context for Leydig Cell Tumor

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MalaCards organs/tissues related to Leydig Cell Tumor:

32
Testis, Ovary, Breast, Testes, Bone, Skeletal muscle, Lung, Prostate, Endothelial, Pituitary

Animal Models for Leydig Cell Tumor or affiliated genes

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MGI Mouse Phenotypes related to Leydig Cell Tumor:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.6CYP19A1, INSL3, INHA, DICER1
2MP:00028738.5NR5A1, DICER1, INHA, CYP19A1
3MP:00053797.6CYP19A1, INSL3, INHA, AFP, DICER1, NR5A1
4MP:00053867.5CYP17A1, CYP19A1, INSL3, AFP, DICER1, NR5A1
5MP:00053767.3CYP17A1, CYP19A1, INHA, AFP, DICER1, NR5A1
6MP:00053897.1NR5A1, CYP17A1, CYP19A1, INSL3, INHA, AFP

Publications for Leydig Cell Tumor

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Articles related to Leydig Cell Tumor:

(show top 50)    (show all 342)
idTitleAuthorsYear
1
Testicular adrenal rest tumor mimicking leydig cell tumor in a patient with congenital adrenal hyperplasia. (24834391)
2014
2
Bilateral sertoli-leydig cell tumor in a primigravida: a rare case. (25002956)
2014
3
Bilateral laparoscopic gonadectomy in a patient with complete androgen insensitivity syndrome and bilateral sertoli-leydig cell tumor: a case report and brief review of the literature. (25032133)
2014
4
A case of successful salvage chemotherapy of recurrent ovarian sertoli-leydig cell tumor. (24328002)
2013
5
"Occult" ovarian Leydig cell tumor: when laboratory tells more than imaging. (24091542)
2013
6
Cervical sarcoma botryoides and ovarian Sertoli-Leydig cell tumor: a case report and review of literature. (21847587)
2012
7
Leydig cell tumor in two brothers with congenital adrenal hyperplasia due to 11-I^ hydroxylase deficiency: a case report. (21259051)
2012
8
Malignant ovarian Sertoli-Leydig cell tumor localized with selective ovarian vein sampling. (23084689)
2012
9
Leydig cell tumor: a report of two cases with unusual presentation. (21045421)
2010
10
Leydig cell tumor of the testis. (19303105)
2009
11
Histologic and immunohistochemical characterization of a testicular mixed germ cell sex cord-stromal tumor and a leydig cell tumor in a dog. (18039910)
2007
12
Estrogen receptor alpha and progesterone receptor expression in ovarian adult granulosa cell tumors and Sertoli-Leydig cell tumors. (17885486)
2007
13
A rare ovarian tumor - Sertoli-Leydig cell tumor with heterologous element. (18311394)
2007
14
Sertoli-Leydig cell tumor of ovary with heterologous element: a case report. (16366107)
2005
15
Human endocrine gland-derived vascular endothelial growth factor: expression early in development and in Leydig cell tumors suggests roles in normal and pathological testis angiogenesis. (15292351)
2004
16
Sertoli-Leydig cell tumor of the ovary. (15216408)
2004
17
Pathologic quiz case: patient with testicular pain. Benign Leydig cell tumor. (14692826)
2004
18
A constitutively active somatic mutation of the human lutropin receptor found in Leydig cell tumors activates the same families of G proteins as germ line mutations associated with Leydig cell hyperplasia. (12933660)
2003
19
Absence of activating mutations in the hot spots of the LH receptor and Gs-alpha genes in Leydig cell tumors. (12150333)
2002
20
Male LH-independent sexual precocity in a 3.5-year-old boy caused by a somatic activating mutation of the LH receptor in a Leydig cell tumor. (11889161)
2002
21
Occult Leydig cell tumor in a patient with gynecomastia. (11497478)
2001
22
Elevated levels of inhibin-A and immunoreactive inhibin in aged male Wistar rats with testicular Leydig cell tumor. (11545298)
2001
23
Leydig-cell tumors caused by an activating mutation of the gene encoding the luteinizing hormone receptor. (10580072)
1999
24
Bilateral ovarian stromal hyperplasia concealing a nonhilar, pure stromal-Leydig cell tumor. A case report. (10394554)
1999
25
Leydig cell tumor of the testis: a clinicopathologic, DNA content, and MIB-1 comparison of nonmetastasizing and metastasizing tumors. (9808128)
1998
26
Activating mutation of the stimulatory G protein (gsp) as a putative cause of ovarian and testicular human stromal Leydig cell tumors. (9626141)
1998
27
Presence of 17 beta-hydroxysteroid dehydrogenase type 3 messenger ribonucleic acid transcript in an ovarian Sertoli-Leydig cell tumor. (9314929)
1997
28
Virilizing stromal Leydig cell tumor (Leydig cell-containing thecoma) of the ovary in pregnancy. A case report with extensive immunohistochemical investigation of the tumor cells. (8542508)
1995
29
Immunohistochemical and biochemical analysis of a human Sertoli-Leydig cell tumor: autonomous steroid production characteristic of ovarian theca cells. (9420846)
1995
30
Precocious puberty in a child with unilateral Leydig cell tumor of the testis following orchiopexy. (8105109)
1993
31
Ultrastructure and immunohistochemistry of a fetal-type Leydig cell tumor. (1448884)
1992
32
Isosexual male precocity due to a Leydig cell tumor. (1291502)
1992
33
Treatment of malignant Leydig cell tumor. (1913469)
1991
34
Diagnosis and resection of an oral contraceptive-suppressible Sertoli-Leydig cell tumor with preservation of fertility and a 7-year follow-up. (2523030)
1989
35
Sertoli-Leydig cell tumor associated with a mature cystic teratoma in a single ovary. (2587573)
1989
36
Ovarian Sertoli-Leydig cell tumor with elevated serum alpha-fetoprotein. (2467733)
1989
37
Steroidogenesis-activator polypeptide isolated from a rat Leydig cell tumor. (3563495)
1987
38
In vitro secretion of deoxycorticosterone by a benign Leydig cell tumor of the testis. (3712595)
1986
39
The rat LTW(m) Leydig cell tumor: cancer anorexia due to estrogen. (6587964)
1984
40
A transplantable rat Leydig cell tumor: binding properties, hormonal responsiveness, and tumor growth. (6100028)
1984
41
Leydig cell tumor in patient on estrogen therapy. (6857903)
1983
42
A Sertoli-Leydig cell tumor and pregnancy. Clinical, endocrine, radiologic, and electron microscopic findings. (6660923)
1983
43
Metastatic Sertoli-Leydig cell tumor of the ovary during pregnancy treated by BV-CAP chemotherapy. (6177244)
1982
44
Ultrastructure of a virilizing ovarian Leydig-cell-tumor. Hilar cell tumor. (6293161)
1982
45
Lipid composition and gonadotropin-mediated lipid metabolism of the M5480 murine Leydig cell tumor. (7441057)
1980
46
Steroidogenesis in HCG-responsive Leydig cell tumor variants. (314019)
1979
47
Leydig-cell tumor of the testis with gynecomastia and elevated estrogen levels. (868795)
1977
48
Estrogen-induced Leydig cell tumor in the mouse: a model system for the study of carcinogenesis and hormone dependency. (11351)
1976
49
Sertoli-Leydig cell tumor of the ovary, with an associated mucinous cystadenoma. An ultrastructural and endocrine study. (4280005)
1974
50
Estrogenic Leydig-cell tumor with multiple metastases in a dog; the problem of bisexual hormone production by gonadal cells. (13367157)
1956

Variations for Leydig Cell Tumor

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Expression for genes affiliated with Leydig Cell Tumor

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Expression patterns in normal tissues for genes affiliated with Leydig Cell Tumor

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Pathways for genes affiliated with Leydig Cell Tumor

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Pathways related to Leydig Cell Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Estrogen biosynthesis60
Androstenedione and testosterone biosynthesis and metabolism p.160
9.6CYP19A1, CYP17A1
29.6CYP19A1, CYP17A1
3
Show member pathways
estradiol biosynthesis II37
androgen biosynthesis37
estradiol biosynthesis I37
progesterone biosynthesis37
9.6CYP19A1, CYP17A1
4
Show member pathways
9.0CYP17A1, CYP19A1, CYP21A2
5
Show member pathways
9.0CYP17A1, CYP19A1, CYP21A2
6
Show member pathways
9.0CYP21A2, CYP19A1, CYP17A1
7
Show member pathways
Glucocorticoid andamp; Mineralcorticoid Metabolism37
9.0CYP21A2, CYP19A1, CYP17A1
88.8CYP19A1, INHA, NR5A1

Compounds for genes affiliated with Leydig Cell Tumor

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Compounds related to Leydig Cell Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 76)
idCompoundScoreTop Affiliating Genes
1methoxyresorufin619.9CYP19A1, CYP17A1
2pf 4981517619.9CYP19A1, CYP17A1
3nafarelin44 61 28 1112.8CYP21A2, CYP19A1
4pregnanediol449.7CYP17A1, CYP21A2
511b-Hydroxyprogesterone249.7CYP21A2, CYP17A1
611beta-Hydroxyprogesterone249.7CYP17A1, CYP21A2
717a-Hydroxypregnenolone249.7CYP17A1, CYP21A2
821-deoxycortisol44 2410.7CYP17A1, CYP21A2
9Pregnenolone24 1110.7CYP17A1, CYP21A2
10atrazine449.6NR5A1, CYP19A1
11acth 1-24449.6CYP21A2, CYP17A1
12pentoxyresorufin44 6110.6CYP19A1, CYP17A1
1317-hydroxypregnenolone449.6CYP21A2, CYP17A1
1411 deoxycortisol449.5CYP21A2, CYP17A1
15aminoglutethimide44 1110.5CYP19A1, CYP21A2
16doca449.5CYP21A2, CYP17A1
17pcb 126449.4CYP19A1, CYP21A2, CYP17A1
18clomiphene citrate449.4CYP19A1, CYP21A2, AFP
1917-hydroxyprogesterone44 2410.4CYP21A2, CYP19A1, CYP17A1
20ketoconazole44 28 24 1112.4CYP19A1, CYP21A2, CYP17A1
21dihydrotestosterone44 28 24 1112.2CYP21A2, CYP19A1, CYP17A1
22NADP249.0CYP19A1, CYP21A2, CYP17A1
23carbon449.0CYP17A1, AFP, CYP21A2
24androstenedione44 249.9INHA, CYP17A1, CYP21A2, CYP19A1
25heme28 24 1110.9CYP17A1, CYP21A2, CYP19A1
26corticosterone44 61 2410.8NR5A1, CYP17A1, CYP21A2
27valine448.8INSL3, CYP21A2, CYP17A1, AFP
28hydrogen44 249.7AFP, CYP21A2, CYP17A1, INHA
29estrone44 28 24 1111.7NR5A1, AFP, CYP19A1, CYP17A1
30vitamin d448.6CYP17A1, AFP, CYP19A1, NR5A1
3117beta-hydroxysteroid448.6NR5A1, CYP21A2, CYP17A1, CYP19A1
32dehydroepiandrosterone sulfate448.6CYP17A1, NR5A1, CYP21A2, CYP19A1
33dhea448.6CYP17A1, CYP19A1, CYP21A2, NR5A1
34cyclic amp44 249.5CYP17A1, INHA, INSL3, NR5A1
35acth448.5INHA, CYP21A2, NR5A1, CYP17A1
36ribonucleic acid448.4NR5A1, INHA, CYP17A1, CYP21A2
37cycloheximide448.4NR5A1, CYP21A2, CYP19A1, CYP17A1
38forskolin44 50 1110.4NR5A1, INHA, CYP17A1, CYP21A2
39diethylstilbestrol44 28 1110.3NR5A1, AFP, INSL3, CYP17A1, CYP19A1
40dexamethasone44 50 28 1111.1CYP19A1, CYP21A2, AFP, CYP17A1
41gnrh448.1CYP17A1, INHA, NR5A1, CYP19A1, CYP21A2
42cholesterol44 28 24 1111.1CYP17A1, AFP, NR5A1, CYP21A2
43threonine448.0NR5A1, CYP21A2, CYP17A1, AFP, INSL3
44oligonucleotide447.9INHA, AFP, NR5A1, CYP21A2, CYP17A1
453beta-hydroxysteroid447.7CYP19A1, INSL3, NR5A1, INHA, CYP21A2, CYP17A1
46estradiol44 24 119.6CYP19A1, AFP, INHA, CYP17A1, NR5A1, CYP21A2
47progesterone44 28 61 24 1111.6NR5A1, AFP, INHA, CYP21A2, CYP19A1, CYP17A1
48testosterone44 61 24 1110.2CYP17A1, CYP19A1, CYP21A2, INSL3, AFP, NR5A1
49steroid447.2NR5A1, INHA, INSL3, CYP21A2, CYP19A1, CYP17A1
50estrogen447.2NR5A1, CYP17A1, AFP, CYP19A1, CYP21A2, INSL3

GO Terms for genes affiliated with Leydig Cell Tumor

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Biological processes related to Leydig Cell Tumor according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1regulation of cell cycleGO:0517269.7DICER1, INHA
2progesterone metabolic processGO:0424489.6AFP, CYP17A1
3steroid biosynthetic processGO:0066949.5CYP17A1, CYP19A1
4glucocorticoid biosynthetic processGO:0067049.4CYP17A1, CYP21A2
5sterol metabolic processGO:0161259.2CYP21A2, CYP19A1, CYP17A1
6steroid metabolic processGO:0082029.2CYP21A2, CYP19A1, CYP17A1
7adrenal gland developmentGO:0303259.1NR5A1, CYP17A1
8xenobiotic metabolic processGO:0068059.0CYP21A2, CYP19A1, CYP17A1
9male gonad developmentGO:0085849.0INSL3, INHA, NR5A1
10cell-cell signalingGO:0072678.5NR5A1, INHA, INSL3

Molecular functions related to Leydig Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.6INHA, INSL3
2oxygen bindingGO:0198259.3CYP19A1, CYP17A1
3heme bindingGO:0200379.0CYP21A2, CYP19A1, CYP17A1
4iron ion bindingGO:0055068.9CYP17A1, CYP19A1, CYP21A2

Products for genes affiliated with Leydig Cell Tumor

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Sources for Leydig Cell Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet