MCID: LYD001
MIFTS: 42

Leydig Cell Tumor malady

Cancer diseases category

Aliases & Classifications for Leydig Cell Tumor

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 55SNOMED-CT, 33MeSH, 38NCIt
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Leydig Cell Tumor, Aliases & Descriptions:

Name: Leydig Cell Tumor 9 11 43 60
 
Leydig Cell Neoplasm 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology9 DOID:2696
MeSH33 D007984
SNOMED-CT55 189739005, 45002009
NCIt38 C3188

Summaries for Leydig Cell Tumor

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MalaCards based summary: Leydig Cell Tumor, also known as leydig cell neoplasm, is related to sertoli-leydig cell tumor and goiter. An important gene associated with Leydig Cell Tumor is DICER1 (dicer 1, ribonuclease type III), and among its related pathways are Estrone metabolism and Ovarian steroidogenesis. The compounds pf 4981517 and methoxyresorufin have been mentioned in the context of this disorder. Affiliated tissues include testis, ovary and breast, and related mouse phenotypes are skeleton and normal.

Related Diseases for Leydig Cell Tumor

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Diseases in the Leydig Cell Tumor family:

Malignant Leydig Cell Tumor

Diseases related to Leydig Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 92)
idRelated DiseaseScoreTop Affiliating Genes
1sertoli-leydig cell tumor32.2AFP, INHA
2goiter31.1INSL3
3gynecomastia31.1INHA, CYP19A1, CYP17A1
4precocious puberty30.9CYP21A2, CYP19A1
5sertoli cell tumor30.7INHA, CYP19A1
6adrenal rest tumor30.6CYP21A2, NR5A1
7pseudohermaphroditism30.6CYP17A1, CYP19A1
8hyperandrogenism30.5CYP17A1, CYP19A1, CYP21A2, INSL3
9cryptorchidism30.5CYP19A1, INSL3, NR5A1
10dysgerminoma30.5INHA, AFP
11congenital adrenal hyperplasia30.4CYP17A1, CYP19A1, CYP21A2, NR5A1
12adrenal adenoma30.2CYP17A1, CYP19A1, CYP21A2
13adenoma29.8CYP17A1, CYP21A2, INHA, NR5A1
14choriocarcinoma29.8CYP19A1, INHA, AFP, NR5A1
15klinefelter's syndrome29.7CYP19A1, CYP21A2, INHA, NR5A1
16adenocarcinoma29.7CYP21A2, INHA, AFP, NR5A1
17infertility29.5CYP19A1, CYP21A2, INSL3, INHA, NR5A1
18breast cancer29.3CYP17A1, CYP19A1, CYP21A2, INHA, NR5A1
19testicular leydig cell tumor10.8
20malignant leydig cell tumor10.8
21hypercalcemia10.6
22goiter, multinodular 1, with or without sertoli-leydig cell tumors10.5
23androgen insensitivity10.5
24malignant sertoli-leydig cell tumor of ovary10.5
25complete androgen insensitivity syndrome10.5
26malignant testicular leydig cell tumor10.5
27sarcoma10.5
28cystadenoma10.4
29multinodular goiter10.4
30malignant sertoli-leydig cell tumor10.4
31teratoma10.4
32acute adrenal insufficiency10.4CYP21A2
33premature ovarian failure10.3INHA
34amenorrhea10.3
35cervicitis10.3
36mature teratoma10.3
37rhabdomyosarcoma10.3
38gonadal dysgenesis10.3NR5A1
39endometrial stromal sarcoma10.2CYP19A1, INHA
40adrenocortical carcinoma10.2NR5A1
41endodermal sinus tumor10.2AFP, INHA
42alopecia, androgenetic, 110.2CYP19A1, CYP21A2
43peutz-jeghers syndrome10.2CYP19A1, INHA
44adrenal hyperplasia, congenital, due to 21-hydroxylase deficiency10.2CYP21A2, INHA
45prostate cancer10.2
46retinoblastoma10.2
47hematopoietic stem cell transplantation10.2
48islet cell tumor10.2
49neuroectodermal tumor10.2
50mucinous adenocarcinoma10.2

Graphical network of the top 20 diseases related to Leydig Cell Tumor:



Diseases related to leydig cell tumor

Symptoms for Leydig Cell Tumor

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Drugs & Therapeutics for Leydig Cell Tumor

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Drug clinical trials:

Search ClinicalTrials for Leydig Cell Tumor

Search NIH Clinical Center for Leydig Cell Tumor

Genetic Tests for Leydig Cell Tumor

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Anatomical Context for Leydig Cell Tumor

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MalaCards organs/tissues related to Leydig Cell Tumor:

31
Testis, Ovary, Breast, Testes, Bone, Skeletal muscle, Liver, Lung, Prostate, Endothelial, Pituitary

Animal Models for Leydig Cell Tumor or affiliated genes

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MGI Mouse Phenotypes related to Leydig Cell Tumor:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.6CYP19A1, INSL3, INHA, DICER1
2MP:00028738.5NR5A1, DICER1, INHA, CYP19A1
3MP:00053797.6CYP19A1, INSL3, INHA, AFP, DICER1, NR5A1
4MP:00053867.5CYP17A1, CYP19A1, INSL3, AFP, DICER1, NR5A1
5MP:00053767.3CYP17A1, CYP19A1, INHA, AFP, DICER1, NR5A1
6MP:00053897.1NR5A1, CYP17A1, CYP19A1, INSL3, INHA, AFP

Publications for Leydig Cell Tumor

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Articles related to Leydig Cell Tumor:

(show top 50)    (show all 344)
idTitleAuthorsYear
1
Leydig cell tumor incidentally detected by fused FDG-PET/MRI. (25636443)
2015
2
Testicular adrenal rest tumor mimicking leydig cell tumor in a patient with congenital adrenal hyperplasia. (24834391)
2014
3
Bilateral sertoli-leydig cell tumor in a primigravida: a rare case. (25002956)
2014
4
Bilateral laparoscopic gonadectomy in a patient with complete androgen insensitivity syndrome and bilateral sertoli-leydig cell tumor: a case report and brief review of the literature. (25032133)
2014
5
A case of successful salvage chemotherapy of recurrent ovarian sertoli-leydig cell tumor. (24328002)
2013
6
"Occult" ovarian Leydig cell tumor: when laboratory tells more than imaging. (24091542)
2013
7
Cervical sarcoma botryoides and ovarian Sertoli-Leydig cell tumor: a case report and review of literature. (21847587)
2012
8
Leydig cell tumor in two brothers with congenital adrenal hyperplasia due to 11-I^ hydroxylase deficiency: a case report. (21259051)
2012
9
Malignant ovarian Sertoli-Leydig cell tumor localized with selective ovarian vein sampling. (23084689)
2012
10
Leydig cell tumor: a report of two cases with unusual presentation. (21045421)
2010
11
Leydig cell tumor of the testis. (19303105)
2009
12
Histologic and immunohistochemical characterization of a testicular mixed germ cell sex cord-stromal tumor and a leydig cell tumor in a dog. (18039910)
2007
13
Estrogen receptor alpha and progesterone receptor expression in ovarian adult granulosa cell tumors and Sertoli-Leydig cell tumors. (17885486)
2007
14
A rare ovarian tumor - Sertoli-Leydig cell tumor with heterologous element. (18311394)
2007
15
Sertoli-Leydig cell tumor of ovary with heterologous element: a case report. (16366107)
2005
16
Human endocrine gland-derived vascular endothelial growth factor: expression early in development and in Leydig cell tumors suggests roles in normal and pathological testis angiogenesis. (15292351)
2004
17
Sertoli-Leydig cell tumor of the ovary. (15216408)
2004
18
Pathologic quiz case: patient with testicular pain. Benign Leydig cell tumor. (14692826)
2004
19
A constitutively active somatic mutation of the human lutropin receptor found in Leydig cell tumors activates the same families of G proteins as germ line mutations associated with Leydig cell hyperplasia. (12933660)
2003
20
Absence of activating mutations in the hot spots of the LH receptor and Gs-alpha genes in Leydig cell tumors. (12150333)
2002
21
Male LH-independent sexual precocity in a 3.5-year-old boy caused by a somatic activating mutation of the LH receptor in a Leydig cell tumor. (11889161)
2002
22
Occult Leydig cell tumor in a patient with gynecomastia. (11497478)
2001
23
Elevated levels of inhibin-A and immunoreactive inhibin in aged male Wistar rats with testicular Leydig cell tumor. (11545298)
2001
24
Leydig-cell tumors caused by an activating mutation of the gene encoding the luteinizing hormone receptor. (10580072)
1999
25
Bilateral ovarian stromal hyperplasia concealing a nonhilar, pure stromal-Leydig cell tumor. A case report. (10394554)
1999
26
Leydig cell tumor of the testis: a clinicopathologic, DNA content, and MIB-1 comparison of nonmetastasizing and metastasizing tumors. (9808128)
1998
27
Activating mutation of the stimulatory G protein (gsp) as a putative cause of ovarian and testicular human stromal Leydig cell tumors. (9626141)
1998
28
Presence of 17 beta-hydroxysteroid dehydrogenase type 3 messenger ribonucleic acid transcript in an ovarian Sertoli-Leydig cell tumor. (9314929)
1997
29
Virilizing stromal Leydig cell tumor (Leydig cell-containing thecoma) of the ovary in pregnancy. A case report with extensive immunohistochemical investigation of the tumor cells. (8542508)
1995
30
Immunohistochemical and biochemical analysis of a human Sertoli-Leydig cell tumor: autonomous steroid production characteristic of ovarian theca cells. (9420846)
1995
31
Precocious puberty in a child with unilateral Leydig cell tumor of the testis following orchiopexy. (8105109)
1993
32
Ultrastructure and immunohistochemistry of a fetal-type Leydig cell tumor. (1448884)
1992
33
Isosexual male precocity due to a Leydig cell tumor. (1291502)
1992
34
Treatment of malignant Leydig cell tumor. (1913469)
1991
35
Diagnosis and resection of an oral contraceptive-suppressible Sertoli-Leydig cell tumor with preservation of fertility and a 7-year follow-up. (2523030)
1989
36
Sertoli-Leydig cell tumor associated with a mature cystic teratoma in a single ovary. (2587573)
1989
37
Ovarian Sertoli-Leydig cell tumor with elevated serum alpha-fetoprotein. (2467733)
1989
38
Steroidogenesis-activator polypeptide isolated from a rat Leydig cell tumor. (3563495)
1987
39
In vitro secretion of deoxycorticosterone by a benign Leydig cell tumor of the testis. (3712595)
1986
40
The rat LTW(m) Leydig cell tumor: cancer anorexia due to estrogen. (6587964)
1984
41
A transplantable rat Leydig cell tumor: binding properties, hormonal responsiveness, and tumor growth. (6100028)
1984
42
Leydig cell tumor in patient on estrogen therapy. (6857903)
1983
43
Metastatic Sertoli-Leydig cell tumor of the ovary during pregnancy treated by BV-CAP chemotherapy. (6177244)
1982
44
Ultrastructure of a virilizing ovarian Leydig-cell-tumor. Hilar cell tumor. (6293161)
1982
45
Lipid composition and gonadotropin-mediated lipid metabolism of the M5480 murine Leydig cell tumor. (7441057)
1980
46
Steroidogenesis in HCG-responsive Leydig cell tumor variants. (314019)
1979
47
Leydig-cell tumor of the testis with gynecomastia and elevated estrogen levels. (868795)
1977
48
Estrogen-induced Leydig cell tumor in the mouse: a model system for the study of carcinogenesis and hormone dependency. (11351)
1976
49
Sertoli-Leydig cell tumor of the ovary, with an associated mucinous cystadenoma. An ultrastructural and endocrine study. (4280005)
1974
50
Estrogenic Leydig-cell tumor with multiple metastases in a dog; the problem of bisexual hormone production by gonadal cells. (13367157)
1956

Variations for Leydig Cell Tumor

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Expression for genes affiliated with Leydig Cell Tumor

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Search GEO for disease gene expression data for Leydig Cell Tumor.

Pathways for genes affiliated with Leydig Cell Tumor

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Pathways related to Leydig Cell Tumor according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Estrogen biosynthesis58
Androstenedione and testosterone biosynthesis and metabolism p.158
9.6CYP19A1, CYP17A1
29.6CYP19A1, CYP17A1
3
Show member pathways
estradiol biosynthesis II36
androgen biosynthesis36
estradiol biosynthesis I36
progesterone biosynthesis36
9.6CYP19A1, CYP17A1
4
Show member pathways
9.0CYP17A1, CYP19A1, CYP21A2
5
Show member pathways
9.0CYP17A1, CYP19A1, CYP21A2
6
Show member pathways
9.0CYP21A2, CYP19A1, CYP17A1
7
Show member pathways
Glucocorticoid andamp; Mineralcorticoid Metabolism36
9.0CYP21A2, CYP19A1, CYP17A1
88.8CYP19A1, INHA, NR5A1

Compounds for genes affiliated with Leydig Cell Tumor

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Compounds related to Leydig Cell Tumor according to GeneCards Suite gene sharing:

(show top 50)    (show all 76)
idCompoundScoreTop Affiliating Genes
1pf 4981517599.9CYP17A1, CYP19A1
2methoxyresorufin599.9CYP17A1, CYP19A1
3nafarelin43 59 28 1212.8CYP19A1, CYP21A2
4pregnanediol439.7CYP21A2, CYP17A1
511beta-Hydroxyprogesterone249.7CYP17A1, CYP21A2
611b-Hydroxyprogesterone249.7CYP17A1, CYP21A2
721-deoxycortisol43 2410.7CYP21A2, CYP17A1
817a-Hydroxypregnenolone249.7CYP21A2, CYP17A1
9Pregnenolone24 1210.7CYP21A2, CYP17A1
10atrazine439.6CYP19A1, NR5A1
11acth 1-24439.6CYP17A1, CYP21A2
12pentoxyresorufin43 5910.6CYP19A1, CYP17A1
1317-hydroxypregnenolone439.6CYP17A1, CYP21A2
14doca439.5CYP17A1, CYP21A2
1511 deoxycortisol439.5CYP17A1, CYP21A2
16aminoglutethimide43 1210.5CYP19A1, CYP21A2
17pcb 126439.4CYP21A2, CYP19A1, CYP17A1
18clomiphene citrate439.4AFP, CYP21A2, CYP19A1
1917-hydroxyprogesterone43 2410.4CYP17A1, CYP19A1, CYP21A2
20ketoconazole43 28 24 1212.4CYP21A2, CYP19A1, CYP17A1
21dihydrotestosterone43 28 24 1212.2CYP21A2, CYP19A1, CYP17A1
22NADP249.0CYP21A2, CYP19A1, CYP17A1
23carbon439.0AFP, CYP21A2, CYP17A1
24androstenedione43 249.9CYP17A1, CYP19A1, CYP21A2, INHA
25heme28 24 1210.9CYP21A2, CYP19A1, CYP17A1
26corticosterone43 59 2410.8NR5A1, CYP21A2, CYP17A1
27valine438.8AFP, INSL3, CYP21A2, CYP17A1
28hydrogen43 249.7CYP17A1, CYP21A2, INHA, AFP
29estrone43 28 24 1211.7CYP17A1, CYP19A1, AFP, NR5A1
30vitamin d438.6CYP17A1, CYP19A1, AFP, NR5A1
31dehydroepiandrosterone sulfate438.6CYP17A1, CYP19A1, CYP21A2, NR5A1
3217beta-hydroxysteroid438.6CYP17A1, CYP19A1, CYP21A2, NR5A1
33dhea438.6CYP17A1, CYP19A1, CYP21A2, NR5A1
34cyclic amp43 249.5CYP17A1, INSL3, INHA, NR5A1
35acth438.5CYP17A1, CYP21A2, INHA, NR5A1
36ribonucleic acid438.4CYP17A1, CYP21A2, INHA, NR5A1
37cycloheximide438.4NR5A1, CYP21A2, CYP19A1, CYP17A1
38forskolin43 49 1210.4CYP17A1, CYP21A2, INHA, NR5A1
39diethylstilbestrol43 28 1210.3CYP17A1, CYP19A1, INSL3, AFP, NR5A1
40dexamethasone43 49 28 1211.1CYP17A1, CYP19A1, CYP21A2, AFP
41gnrh438.1CYP17A1, CYP19A1, CYP21A2, INHA, NR5A1
42cholesterol43 28 24 1211.1CYP17A1, CYP21A2, AFP, NR5A1
43threonine438.0CYP17A1, CYP21A2, INSL3, AFP, NR5A1
44oligonucleotide437.9CYP17A1, CYP21A2, INHA, AFP, NR5A1
453beta-hydroxysteroid437.7NR5A1, INHA, INSL3, CYP21A2, CYP19A1, CYP17A1
46estradiol43 24 129.6CYP17A1, CYP19A1, CYP21A2, INHA, AFP, NR5A1
47progesterone43 28 59 24 1211.6CYP17A1, CYP19A1, CYP21A2, INHA, AFP, NR5A1
48testosterone43 59 24 1210.2CYP17A1, CYP19A1, CYP21A2, INSL3, INHA, AFP
49steroid437.2CYP17A1, CYP19A1, CYP21A2, INSL3, INHA, AFP
50estrogen437.2CYP17A1, CYP19A1, CYP21A2, INSL3, INHA, AFP

GO Terms for genes affiliated with Leydig Cell Tumor

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Biological processes related to Leydig Cell Tumor according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1regulation of cell cycleGO:00517269.7DICER1, INHA
2progesterone metabolic processGO:00424489.6AFP, CYP17A1
3steroid biosynthetic processGO:00066949.5CYP17A1, CYP19A1
4glucocorticoid biosynthetic processGO:00067049.4CYP17A1, CYP21A2
5sterol metabolic processGO:00161259.2CYP21A2, CYP19A1, CYP17A1
6steroid metabolic processGO:00082029.2CYP21A2, CYP19A1, CYP17A1
7adrenal gland developmentGO:00303259.1NR5A1, CYP17A1
8xenobiotic metabolic processGO:00068059.0CYP21A2, CYP19A1, CYP17A1
9male gonad developmentGO:00085849.0INSL3, INHA, NR5A1
10cell-cell signalingGO:00072678.5NR5A1, INHA, INSL3

Molecular functions related to Leydig Cell Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051799.6INHA, INSL3
2oxygen bindingGO:00198259.3CYP19A1, CYP17A1
3heme bindingGO:00200379.0CYP21A2, CYP19A1, CYP17A1
4iron ion bindingGO:00055068.9CYP17A1, CYP19A1, CYP21A2

Products for genes affiliated with Leydig Cell Tumor

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Sources for Leydig Cell Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet