Leydig Cell Tumor malady

Wikipedia: Leydig cell tumour, also Leydig cell tumor (US spelling), (testicular) interstitial cell tumour and...⁴⁴ more...

MalaCards: Leydig Cell Tumor, also known as leydig cell neoplasm, is related to testicular leydig cell tumor and sertoli-leydig cell tumor. An important gene associated with Leydig Cell Tumor is C19orf53 (chromosome 19 open reading frame 53), and among its related pathways are Actin-Based Motility by Rho Family GTPases and Steroid hormone biosynthesis. The compounds b 723 and diethylstilbestrol have been mentioned in the context of this disorder. Affiliated tissues include ovary, testis and endothelial, and related mouse phenotypes are respiratory system and normal.

Aliases & Descriptions:

leydig cell tumor 6 8 32 43 leydig cell neoplasm 6

Diseases related to leydig cell tumor by text searches and GeneDecks gene sharing:

(show top 50)    (show all 694)

id	Related Disease	Score	Top Affiliating Genes
1	testicular leydig cell tumor	34.3	CGB, TNFSF14, CYP19A1, CYP21A2
2	sertoli-leydig cell tumor	33.9	VIM, MYOG, MUC1, MUC16, CEACAM3, FSHR
3	21-hydroxylase deficiency	30.8	INHA, CYP21A2, SYP
4	desmoplastic small round cell tumor	30.7	MUC1, WT1, DES
5	gynecomastia	29.6	BRD2, MUC1, CGA, CGB, CGB5, INHA
6	androgen insensitivity syndrome	29.4	BRD2, CGA, INHA, IGF2, CYP19A1, SRD5A1
7	amenorrhea	29.4	BRD2, LHCGR, CGA, FSHR, ALPP, GNRH1
8	ovarian sex cord tumors	29.0	VIM, MUC1, MUC16, CEACAM3, FSHR, ENO2
9	goiter	28.4	CGA, INSL3, ALPP, GNAS, PTH, DICER1
10	sertoli cell tumor	28.2	KIT, VIM, MUC1, CGB, CGB5, MLANA
11	virilization	28.1	LHCGR, CGA, CGB5, IGF2, GNRH1, HSD3BP4
12	neuroectodermal tumors	28.0	KIT, VIM, MYOG, MUC1, APC, ENO2
13	rhabdomyosarcoma	25.9	VIM, MYOG, MUC16, INHA, INSR, ENO2
14	3-beta-hydroxysteroid dehydrogenase deficiency	13.9	HSD3BP4, CYP17A1, CYP21A2
15	adrenal rest tumor	13.9	CGB, CYP21A2, NR5A1
16	46,xy disorder of sex development and 46,xy complete gonadal dysgenesis	13.9	SRY, NR0B1, NR5A1
17	luteoma	13.9	CGA, CYP21A2, SRY
18	malignant sertoli cell tumor	13.9	CGB5, ALPP, AFP
19	precocious puberty, male	13.8	LHCGR, FSHR, CYP19A1, CYP21A2
20	mixed epithelial stromal tumour	13.8	INHA, CALB2, CYP19A1, DES, PGR
21	extragonadal germ cell tumor	13.8	CGB, CGB5, AFP
22	adenofibroma	13.8	MUC16, INHA, CALB2, PGR
23	swyer syndrome	13.8	CGB, SRY, NR0B1, NR5A1
24	lipoid congenital adrenal hyperplasia	13.8	CYP11A1, NR5A1, STAR
25	papillary serous carcinoma of the peritoneum	13.8	MUC16, CALB2, WT1
26	cutaneous paget's disease	13.8	MUC1, CEACAM3, KRT7
27	malignant biphasic mesothelioma	13.8	CALB2, WT1, THBD
28	x-linked adrenal hypoplasia congenita	13.8	NR0B1, NR5A1, STAR
29	mixed gonadal dysgenesis	13.8	CYP21A2, SRD5A1, SRY
30	sex cord-gonadal stromal tumor	13.8	VIM, INHA, CALB2
31	leydig cell adenoma	13.8	LHCGR, CGA, GNRH1
32	papillary serous adenocarcinoma	13.8	MUC16, KRT7, PGR
33	late-onset congenital adrenal hyperplasia	13.8	HSD3BP4, CYP21A2, POMC
34	46, xy disorders of sexual development	13.8	CYP17A1, SRY, NR5A1, WT1, STAR
35	mature teratoma	13.8	CGA, CGB, ALPP, AFP
36	nonseminomatous germ cell tumor	13.8	CGA, CGB, CGB5, AFP
37	pancreatic islet cell tumors	13.8	CEACAM3, PTHLH, AFP
38	horseshoe kidney	13.8	CALB2, KRT7, SYP
39	endodermal sinus tumor	13.8	CGA, ALPP, AFP
40	mucinous cystadenocarcinoma	13.8	MUC1, MUC16, CEACAM3, KRT7
41	pleomorphic liposarcoma	13.8	VIM, INHA, CALB2
42	mixed ductal-endocrine carcinoma	13.8	CGB, CGB5, SYP
43	ovarian small cell carcinoma	13.8	INHA, CALB2, PTHLH, DES
44	epithelioid trophoblastic tumor	13.8	CGA, CGB5, INHA, ALPP
45	aorta atresia	13.8	CGA, INHA, GNRH1, CYP19A1
46	mycetoma	13.8	HSD3B1, CYP17A1, CYP19A1
47	botryoid rhabdomyosarcoma	13.8	MYOG, WT1, DES
48	gender identity disorder	13.8	ESR1, CYP19A1, PGR
49	anorchia	13.8	CGA, CGB5, INSL3, SRY, NR5A1
50	secretory meningioma	13.8	VIM, MUC1, KRT7, PGR

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to leydig cell tumor:

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MGI Mouse Phenotypes related to leydig cell tumor:

²⁵ (show all 24)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	9.6	DICER1, INSR, MYOG
2	normal phenotype	MP:0002873	9.1	NR5A1, CREB1, WT1, WDR77, THBD, SYP
3	endocrine/exocrine gland phenotype	MP:0005379	8.8	AFP, STAR, WDR77, WT1, PIWIL4, PIWIL1
4	limbs/digits/tail phenotype	MP:0005371	8.7	DICER1, PTHLH, PTH, ESR1, GNAS, IGF2
5	hematopoietic system phenotype	MP:0005397	8.5	DICER1, PTHLH, PTH, TNFSF14, IGF2, APC
6	no phenotypic analysis	MP:0003012	8.4	SYP, DICER1, TP53, ESR1, GNAS, IGF2
7	liver/biliary system phenotype	MP:0005370	8.3	PRL, NR5A2, CYP19A1, TP53, BRD2, KIT
8	renal/urinary system phenotype	MP:0005367	8.2	WT1, PDGFRB, PTHLH, ESR1, GNRH1, GNAS
9	adipose tissue phenotype	MP:0005375	7.9	TP53, PTHLH, CYP19A1, PDGFRB, POMC, ESR1
10	skeleton phenotype	MP:0005390	7.6	ESR1, TP53, PTH, PTHLH, CYP19A1, PGR
11	embryogenesis phenotype	MP:0005380	7.3	PGR, PRL, CREB1, NR5A2, NR5A1, DICER1
12	tumorigenesis	MP:0002006	7.2	NR0B1, WDR77, PRL, POMC, PGR, AFP
13	nervous system phenotype	MP:0003631	6.9	DICER1, CYP19A1, NR5A1, CREB1, THBD, SYP
14	muscle phenotype	MP:0005369	6.9	CYP11A1, CYP19A1, CRAT, CREB1, PDGFRB, WT1
15	reproductive system phenotype	MP:0005389	6.8	LHCGR, PIWIL4, PIWIL1, NR5A2, NR5A1, NR0B1
16	immune system phenotype	MP:0005387	6.5	PTH, PTHLH, DICER1, CYP11A1, CYP19A1, NR5A2
17	digestive/alimentary phenotype	MP:0005381	6.4	TP53, PTHLH, NR5A2, PDGFRB, EGF, THBD
18	mortality/aging	MP:0010768	6.4	CYP17A1, SRY, NR5A1, NR5A2, CREB1, PDGFRB
19	integument phenotype	MP:0010771	5.9	PTHLH, DICER1, CYP19A1, PDGFRB, EGF, THBD
20	cardiovascular system phenotype	MP:0005385	5.9	CREB1, CRAT, NR5A1, CYP19A1, DICER1, PDGFRB
21	behavior/neurological phenotype	MP:0005386	5.8	CYP17A1, CYP11A1, PTHLH, CALB2, CYP19A1, NR5A1
22	cellular phenotype	MP:0005384	5.4	CRAT, NR5A1, CYP19A1, CYP11A1, DICER1, CREB1
23	growth/size phenotype	MP:0005378	4.3	NR5A2, NR5A1, CYP19A1, CYP11A1, DICER1, PTHLH
24	homeostasis/metabolism phenotype	MP:0005376	3.8	STAR, DES, THBD, WT1, PDGFRB, CREB1

Articles related to leydig cell tumor:

(show all 45)

id	Title	Authors	Year	Affiliating Genes
1	The novel hormone INSL3 is expressed in human testicu lar Leydig cell tumors: a clinical and immunohistochemical study. (19110449)	Rossato M.... Artibani W.	2011	INSL3
2	DICER1 mutations in familial multinodular goiter with and without ovarian Sertoli-Leydig cell tumors. (21205968)	Rio Frio T.... Tischkowitz M.	2011	DICER1
3	7,12-dimethylbenz[a]anthracene induces sertoli-leydig -cell tumors in the follicle-depleted ovaries of mice treated with 4-vinylcyclo hexene diepoxide. (20158943)	Craig Z.R.... Hoyer P.B.	2010	INHA, KRT7
4	Ovarian involvement by desmoplastic small round cell tumor with leydig cell hyperplasia showing an unusual immunophenotype (cytokera tin negative, calretinin and inhibin positive) mimicking poorly differentiated sertoli leydig cell tumor. (19851210)	Engohan-Aloghe C.... NoAl J.C.	2009	CALB2
5	Leydig cell tumor and malignant lymphoma in a patient with nonclassical 21-hydroxylase deficiency. (19367056)	Inaba H.... Hashizume K.	2009	CYP21A2
6	Ovarian Sertoli-Leydig cell tumor with heterologous gastrointestinal epithelium as a source of alpha-fetoprotein: a case report. (18588618)	Watanabe T.... Sato A.	2008	AFP
7	A novel splice mutation in the TP53 gene associated with Leydig cell tumor and primitive neuroectodermal tumor. (17066464)	Stecher C.W.... Hasle H.	2008	TP53
8	Detection of aromatase and estrogen receptors (ERalpha, ERbeta1, ERbeta2) in human Leydig cell tumor. (17656605)	Carpino A.... AndA^ S.	2007	ESR1, CYP19A1
9	Estrogen receptor alpha and progesterone receptor expression in ovarian adult granulosa cell tumors and Sertoli-Leydig cell tumors. (17885486)	Farinola M.A.... Vang R.	2007	PGR, ESR1
10	Primary amenorrhea in a young Polish woman with complete androgen insensitivity syndrome and Sertoli-Leydig cell tumor: identification of a new androgen receptor gene mutation and evidence of aromatase hyperactivity and apoptosis dysregulation within the tumor. (17852420)	Jarzabek K.... Sultan C.	2007	CYP19A1
11	Ovarian Sertoli-Leydig cell tumor of intermediate grade with heterologous elements of rhabdomyosarcoma. A case report and a review of the literature. (16979522)	Grove A.... Vestergaard V.	2006	INHA, MYOG
12	Long-term followup and clinical characteristics of testicular Leydig cell tumor: experience with 24 cases. (17070249)	Carmignani L.... Pizzocaro G.	2006	CGB
13	Adult leydig cell tumors of the testis caused by germline fumarate hydratase mutations. (16757530)	Carvajal-Carmona L.G.... Tomlinson I.P.	2006	LHCGR, FH, GNAL
14	Leydig cell tumor of the testis with histological and immunohistochemical features of malignancy in a 1-year-old boy with isosexual pseudoprecocity. (17041205)	Drut R.... Bacchi C.	2006	CALB2
15	Large cell calcifying Sertoli cell tumor of the testis: comparative immunohistochemical study with Leydig cell tumor. (15943795)	Sato K.... Katsuda S.	2005	INHA, CALB2
16	Uterine retiform sertoli-leydig cell tumor: report of a case providing additional evidence that uterine tumors resembling ovarian sex cord tumors have a histologic and immunohistochemical phenotype of genuine sex cord tumors. (16175078)	Czernobilsky B.... Lifschitz-Mercer B.	2005	VIM, ENO2, DES
17	Imatinib mesylate inhibits Leydig cell tumor growth: evidence for in vitro and in vivo activity. (15753388)	Basciani S.... Gnessi L.	2005	PDGFRB, KIT
18	Non islet cell tumor hypoglycaemia in a metastatic Leydig cell tumor. (16227169)	Mukherjee S.... Weston P.J.	2005	INSR, IGF2
19	Human endocrine gland-derived vascular endothelial growth factor: expression early in development and in Leydig cell tumors suggests roles in normal and pathological testis angiogenesis. (15292351)	Samson M.... Ferrara N.	2004	PROK1
20	A constitutively active somatic mutation of the human lutropin receptor found in Leydig cell tumors activates the same families of G proteins as germ line mutations associated with Leydig cell hyperplasia. (12933660)	Hirakawa T.... Ascoli M.	2003	LHCGR
21	Absence of activating mutations in the hot spots of the LH receptor and Gs-alpha genes in Leydig cell tumors. (12150333)	Vieira T.C.... Abucham J.	2002	GNAS, LHCGR
22	Sertoli-Leydig cell tumor of the ovary, a rare cause of precocious puberty in a 12-month-old infant. (11788622)	Choong C.S.... Burger H.G.	2002	FSHR, NR5A1
23	Leydig cell tumors of the testis with unusual features: adipose differentiation, calcification with ossification, and spindle-shaped tumor cells. (12409718)	Ulbright T.M.... Young R.H.	2002	INHA
24	Mutational analysis of the luteinizing hormone receptor gene in two individuals with Leydig cell tumors. (11857565)	Canto P.... Mendez J.P.	2002	LHCGR
25	Occult Leydig cell tumor in a patient with gynecomastia. (11497478)	Anderson M.S.... Biller B.M.	2001	PRL
26	Overexpression of aromatase leads to development of testicular leydig cell tumors : an in vivo model for hormone-mediated TesticularCancer. (10623684)	Fowler K.A.... Tekmal R.R.	2000	CYP19A1
27	Hepatocytic differentiation in retiform Sertoli-Leydig cell tumors: distinguishing a heterologous element from Leydig cells. (10374766)	Mooney E.E.... Tavassoli F.A.	1999	AFP
28	Leydig-cell tumors caused by an activating mutation of the gene encoding the luteinizing hormone receptor. (10580072)	Liu G.... Shenker A.	1999	LHCGR
29	Relaxin-like factor expression in a human ovarian Sertoli-Leydig cell tumor. (10519633)	Klonisch T.... Steger K.	1999	INSL3
30	Activating mutation of the stimulatory G protein (gsp) as a putative cause of ovarian and testicular human stromal Leydig cell tumors. (9626141)	Fragoso M.C.... Villares S.M.	1998	APC, GNAS
31	Hormonal profile of patients with Leydig cell tumors: a urologic cause of gynecomastia. (9973810)	Xciarra A.... Di Silverio F.	1998	CGB5
32	A virilizing Leydig cell tumor of the ovary associate d with stromal hyperplasia under gonadotropin control. (9492110)	Marcondes J.A.... Wajchenberg B.L.	1997	GNRH1
33	Leydig cell tumor of the testis: a cytohistological, immunohistochemical, and ultrastructural case study. (9099550)	Assi A.... Pasquinelli G.	1997	VIM
34	Gynecomastia and Leydig cell tumor (9235082)	CatalA! Bauset M.... GonzA!lez-Bayo E.	1997	CGA
35	Ovarian Sertoli-Leydig cell tumor: a SRY gene-independent pathway of pseudomale gonadal differentiation. (9343329)	Hittmair A.... Dirnhofer S.	1997	VIM, SRY
36	Leydig cell tumor of the testis: analysis of testosterone production and secretion by three-dimensional histoculture. (8732455)	Sasano H.... Nagura H.	1996	CYP17A1
37	Immunohistochemical and biochemical analysis of a human Sertoli-Leydig cell tumor: autonomous steroid production characteristic of ovarian theca cells. (9420846)	Sawetawan C.... Carr B.R.	1995	CYP17A1, HSD3BP4
38	Regulation of parathyroid hormone-related peptide production in vitro by the rat hypercalcemic Leydig cell tumor H-500. (8462465)	Liu B.... Rabbani S.A.	1993	EGF, PRL, PTHLH
39	Ultrastructure and immunohistochemistry of a fetal-type Leydig cell tumor. (1448884)	Ekfors T.O.... Nurmi M.J.	1992	HSD3BP4
40	Sertoli-Leydig cell tumor of the ovary: a rare cause of amenorrhea. (1565381)	Larsen W.G.... Frieder R.	1992	AFP
41	Extraadrenal expression of steroid 21-hydroxylase and 11 beta-hydroxylase by a benign testicular Leydig cell tumor. (1751389)	Namiki M.... Sonoda T.	1991	CYP21A2
42	Leydig cell tumor estrogen secretion: suppression by a gonadotropin releasing hormone agonist. (1940064)	Valensi P.... Sebaoun J.	1991	GNRH1
43	A case of ovarian Sertoli-Leydig cell tumor associated with high serum alpha-fetoprotein (AFP) concentration (1698212)	Ohyama N.... Igarashi S.	1990	AFP
44	The structure of cDNA clones encoding the aromatase P-450 isolated from a rat Leydig cell tumor line demonstrates differential processing of aromatase mRNA in rat ovary and a neoplastic cell line. (2340950)	Lephart E.D.... McPhaul M.J.	1990	CYP19A1
45	Pituitary-like proopiomelanocortin transcripts in human Leydig cell tumors. (2394836)	de Keyzer Y.... Bertagna X.	1990	POMC

Genes related to leydig cell tumor according to GeneCards:

(show top 50)    (show all 67)

id	Symbol	Description	Score	GeneCards Section Context
1	C19orf53	chromosome 19 open reading frame 53	11.1	Aliases & Descriptions, Proteins
2	CALB2	calbindin 2	11.0	Publications
3	CYP19A1	cytochrome P450, family 19, subfamily A, polypeptide 1	11.0	Publications
4	HSD3BP4	hydroxy-delta-5-steroid dehydrogenase, 3 beta, pseudogene 4	11.0	Publications
5	INHA	inhibin, alpha	11.0	Publications
6	NR5A1	nuclear receptor subfamily 5, group A, member 1	11.0	Publications
7	AFP	alpha-fetoprotein	11.0	Publications
8	CYP21A2	cytochrome P450, family 21, subfamily A, polypeptide 2	11.0	Publications
9	KRT7	keratin 7	11.0	Publications
10	CYP17A1	cytochrome P450, family 17, subfamily A, polypeptide 1	11.0	Publications
11	WT1	Wilms tumor 1	11.0
12	MUC1	mucin 1, cell surface associated	11.0	Publications
13	PGR	progesterone receptor	11.0	Publications
14	INSL3	insulin-like 3 (Leydig cell)	11.0	Publications
15	LHCGR	luteinizing hormone/choriogonadotropin receptor	11.0	Publications
16	SRY	sex determining region Y	11.0	Publications
17	MYOG	myogenin (myogenic factor 4)	11.0	Publications
18	HSD3B1	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	11.0
19	DICER1	dicer 1, ribonuclease type III	11.0	Publications
20	CGB	chorionic gonadotropin, beta polypeptide	11.0	Publications
21	SYP	synaptophysin	11.0	Publications
22	CEACAM3	carcinoembryonic antigen-related cell adhesion molecule 3	11.0	Publications
23	NR0B1	nuclear receptor subfamily 0, group B, member 1	11.0
24	STAR	steroidogenic acute regulatory protein	11.0
25	CES1	carboxylesterase 1	11.0
26	CGB5	chorionic gonadotropin, beta polypeptide 5	11.0	Publications
27	LGALS1	lectin, galactoside-binding, soluble, 1	11.0
28	CGA	glycoprotein hormones, alpha polypeptide	11.0	Publications
29	MUC16	mucin 16, cell surface associated	11.0	Publications
30	FSHR	follicle stimulating hormone receptor	11.0	Publications
31	PTHLH	parathyroid hormone-like hormone	11.0	Publications
32	SCARB1	scavenger receptor class B, member 1	11.0
33	PDGFRB	platelet-derived growth factor receptor, beta polypeptide	11.0	Publications
34	PDE4A	phosphodiesterase 4A, cAMP-specific	11.0
35	SRD5A1	steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)	11.0
36	ALPP	alkaline phosphatase, placental	11.0	Publications
37	THBD	thrombomodulin	11.0	Publications
38	GNAS	GNAS complex locus	11.0	Publications
39	VIM	vimentin	11.0	Publications
40	ENO2	enolase 2 (gamma, neuronal)	11.0	Publications
41	GNRH1	gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)	11.0	Publications
42	CYP11A1	cytochrome P450, family 11, subfamily A, polypeptide 1	11.0
43	CRAT	carnitine O-acetyltransferase	11.0
44	TSPO	translocator protein (18kDa)	11.0
45	DES	desmin	11.0	Publications
46	POMC	proopiomelanocortin	11.0	Publications
47	CREB1	cAMP responsive element binding protein 1	11.0
48	ADCY10	adenylate cyclase 10 (soluble)	11.0
49	ESR1	estrogen receptor 1	11.0	Publications
50	PROK1	prokineticin 1	11.0	UniProt Related, Publications

Pathways related to leydig cell tumor according to GeneDecks:

(show all 45)

id	Pathway	Score	Top Affiliating Genes
1	Actin-Based Motility by Rho Family GTPases36	10.4	GNAL
2	Steroid hormone biosynthesis20	10.4	SRD5A1, CYP21A2, CYP19A1, CYP17A1, CYP11A1, HSD3B1
3	Development Role of Activin A in cell differentiation and proliferation10	10.1	LHCGR, STAR, CGA, FSHR, GNAS, CYP11A1
4	Development_Role of Activin A in cell differentiation and proliferation41	10.1	STAR, CREB1, NR5A1, CYP11A1, GNAS, FSHR
5	Metabolism of lipids and lipoproteins38	10.0	STAR, CRAT, SRD5A1, CYP21A2, CYP19A1, CYP17A1
6	Development_Hedgehog and PTH signaling pathways in bone and cartilage development41	10.0	CREB1, PTHLH, PTH, GNAS
7	14-3-3 Induced Intracellular Signaling36	10.0	PROK1, PDGFRB, GNRH1, INSR
8	Development Hedgehog and PTH signaling pathways in bone and cartilage development10	10.0	CREB1, PTHLH, PTH, GNAS
9	Akt Signaling36	9.8	PROK1, PDGFRB, GNAL, KIT
10	Breast Cancer Regulation by Stathmin136	9.7	PROK1, EGF, GNAL
11	Telomerase Components in Cell Signaling36	9.2	PROK1, PDGFRB, TP53, GNRH1, KIT
12	CREB Pathway36	9.1	KIT, IGF2, GNAL, GNRH1, CREB1, PROK1
13	ERK5 Signaling36	9.1	PROK1, PDGFRB, CREB1, GNRH1, GNAL, IGF2
14	JNK Pathway36	9.1	EGF, PDGFRB, TP53, KIT
15	Activation of cAMP-Dependent PKA36	8.9	PROK1, PDGFRB, CREB1, GNRH1, GNAL, IGF2
16	Glioblastoma Multiforme36	8.8	PDGFRB, TP53, IGF2, APC
17	Nuclear Receptor Activation by Vitamin-A36	8.7	PROK1, EGF, PDGFRB, CREB1, GNRH1, IGF2
18	eIF2 Pathway36	8.5	PROK1, EGF, PDGFRB, GNRH1, IGF2, INSR
19	Apoptotic Pathways in Synovial Fibroblasts36	8.5	PROK1, EGF, PDGFRB, TP53, GNRH1, IGF2
20	Rap1 Pathway36	8.4	PROK1, EGF, PDGFRB, GNRH1, GNAL, IGF2
21	p53 Mediated Apoptosis36	8.4	PROK1, EGF, PDGFRB, TP53, GNRH1, IGF2
22	p70S6K Signaling36	8.4	PROK1, EGF, PDGFRB, GNRH1, IGF2, INSR
23	Activation of PKC through GPCR36	8.4	PROK1, EGF, PDGFRB, CREB1, GNRH1, GNAL
24	Mitochondrial Apoptosis36	8.4	PROK1, EGF, PDGFRB, TP53, GNRH1, IGF2
25	Paxillin Interactions36	8.4	PROK1, EGF, PDGFRB, GNRH1, IGF2, INSR
26	Cellular Apoptosis Pathway36	8.4	PROK1, EGF, PDGFRB, TP53, GNRH1, IGF2
27	Ras Pathway36	8.3	PROK1, EGF, GNRH1, IGF2, INSR, KIT
28	eNOS Signaling36	8.3	PROK1, EGF, PDGFRB, ESR1, GNRH1, IGF2
29	GPCR Pathway36	8.3	PROK1, EGF, PDGFRB, CREB1, GNRH1, IGF2
30	DHA Signaling36	8.3	PROK1, EGF, PDGFRB, GNRH1, IGF2, KIT
31	Activation of PKA through GPCR36	8.3	PROK1, PDGFRB, CREB1, GNRH1, GNAL, IGF2
32	ILK Signaling36	8.2	PROK1, EGF, PDGFRB, CREB1, GNRH1, IGF2
33	NFAT in Immune Response36	8.2	PROK1, EGF, PDGFRB, GNRH1, GNAL, IGF2
34	Nanog in Mammalian ESC Pluripotency36	8.0	PROK1, EGF, PDGFRB, GNRH1, IGF2, APC
35	Phospholipase-C Pathway36	8.0	EGF, PDGFRB, CREB1, GNRH1, GNAL, IGF2
36	Pancreatic Adenocarcinoma36	8.0	PROK1, EGF, PDGFRB, TP53, GNRH1, IGF2
37	Intracellular Calcium Signaling36	8.0	GNAL, GNRH1, CREB1, PDGFRB, EGF, PROK1
38	GSK3 Signaling36	7.9	PROK1, EGF, PDGFRB, GNRH1, IGF2, APC
39	Molecular Mechanisms of Cancer36	7.8	EGF, TP53, GNRH1, GNAL, IGF2, APC
40	Estrogen Pathway36	7.8	PROK1, EGF, PDGFRB, CREB1, NR0B1, ESR1
41	Rho Family GTPases36	7.7	PROK1, DES, EGF, PDGFRB, TNFSF14, GNRH1
42	MAPK Signaling36	7.5	PROK1, EGF, PDGFRB, CREB1, TP53, GNRH1
43	JAK-STAT Pathway36	7.5	PRL, PROK1, EGF, PDGFRB, GNRH1, IGF2
44	p38 Signaling36	7.3	PROK1, EGF, PDGFRB, CREB1, TNFSF14, TP53
45	ERK Signaling36	7.1	TNFSF14, CREB1, PDGFRB, EGF, PROK1, TP53

Compounds related to leydig cell tumor according to GeneDecks:

(show top 50)    (show all 312)

id	Compound	Score	Top Affiliating Genes
1	b 72332	9.8	VIM, MUC1, MUC16, CEACAM3, ALPP, CALB2
2	diethylstilbestrol32 9 9	11.5	CGA, CGB5, INSL3, ENO2, GNRH1, ESR1
3	17beta-hydroxysteroid32	9.4	CGA, CGB5, HSD3BP4, ESR1, CYP11A1, CYP17A1
4	hematoxylin32	9.1	KIT, VIM, MUC1, MUC16, CEACAM3, MLANA
5	leuprolide acetate32	8.9	LHCGR, CGA, CGB5, GNRH1, ESR1, CYP19A1
6	h2o232	8.9	PDE4A, MUC16, CGA, CGB5, INSR, ALPP
7	17-hydroxyprogesterone32 18	9.8	MUC16, CGA, CGB5, GNRH1, HSD3B1, HSD3BP4
8	dbc-amp32	8.7	PDE4A, VIM, CGA, CGB5, ENO2, IGF2
9	gnrh32	8.5	VIM, LHCGR, CGB, CGB5, FSHR, INHA
10	dhea32	8.5	CGB5, IGF2, HSD3BP4, CYP11A1, CYP17A1, CYP19A1
11	creatinine32	8.5	MYOG, MUC1, MUC16, CGA, CGB, CGB5
12	alanine32	8.5	LHCGR, SCARB1, CGA, CGB, CEACAM3, FSHR
13	3beta-hydroxysteroid32	8.4	LHCGR, CGA, CGB5, INHA, INSL3, IGF2
14	cysteine32	8.4	MYOG, LGALS1, MUC1, CGB, FSHR, INSR
15	acetylcholine32 9 18 9	11.3	PDE4A, VIM, MYOG, CGA, FSHR, INSR
16	dehydroepiandrosterone sulfate32	8.3	CGA, CGB5, IGF2, GNRH1, HSD3BP4, PTH
17	glucose32	8.3	PDE4A, KIT, MYOG, LGALS1, MUC16, CGB
18	cyclic amp32 18	9.2	PDE4A, LHCGR, SCARB1, CGA, CGB, CGB5
19	estrone32 9 18 9	11.2	CGB5, IGF2, GNRH1, HSD3BP4, ESR1, PTH
20	mifepristone32 42 9 9	11.2	MUC1, CGA, CGB, CGB5, GNRH1, HSD3BP4
21	clomiphene citrate32	8.1	CGA, CGB, CGB5, INSR, GNRH1, ESR1
22	androstenedione32 18	9.0	SCARB1, CGA, CGB, FSHR, INHA, IGF2
23	pge232	8.0	PDE4A, LHCGR, CGA, CGB5, FSHR, APC
24	thyroxine32 18	8.8	CGA, CGB, CEACAM3, INSR, IGF2, ALPP
25	vitamin d32	7.7	VIM, CGA, INSR, APC, IGF2, ALPP
26	lactate32	7.7	KIT, VIM, MUC16, CGA, CGB, CGB5
27	ibmx32	7.6	PDE4A, CGA, CGB5, INSR, ENO2, IGF2
28	lipid32	7.6	PDE4A, VIM, MYOG, SCARB1, LGALS1, MUC1
29	indomethacin32 9 9	9.5	PDE4A, VIM, LGALS1, CGA, CGB5, CES1
30	acth32	7.3	LHCGR, SCARB1, MUC1, CGB5, CEACAM3, INHA
31	progestin32	7.1	VIM, LHCGR, CGA, CGB5, INSR, IGF2
32	dihydrotestosterone32 9 18 9	10.0	VIM, CGA, CGB5, INSR, IGF2, GNRH1
33	norepinephrine32 9 18 9	10.0	PDE4A, CGA, CGB5, APC, ENO2, IGF2
34	estradiol32 9 18 9	9.9	VIM, LHCGR, SCARB1, MUC1, CGA, CGB
35	glutamine32	6.9	PDE4A, KIT, VIM, LGALS1, INSR, APC
36	thymidine32 18	7.8	KIT, MUC1, CEACAM3, FSHR, INSR, ENO2
37	ribonucleic acid32	6.8	KIT, MYOG, LHCGR, SCARB1, MUC1, CGA
38	tamoxifen32 34 9 9	9.7	PDE4A, VIM, MUC1, CGA, CGB5, CEACAM3
39	adenylate32	6.7	PDE4A, VIM, MYOG, LHCGR, CGA, CGB5
40	actinomycin d32	6.6	PDE4A, KIT, VIM, MUC1, CGA, CGB5
41	retinoic acid32 42 18	8.5	PDE4A, KIT, MYOG, CGB5, APC, ENO2
42	forskolin32 42 9 9	9.2	PDE4A, VIM, MYOG, LHCGR, MUC1, CGA
43	arginine32	6.1	PDE4A, VIM, LHCGR, LGALS1, CGA, CGB5
44	tyrosine32	5.7	PDE4A, KIT, MYOG, LGALS1, MUC1, MUC16
45	dexamethasone32 42 34 9 9	9.6	PDE4A, VIM, LGALS1, MUC1, MUC16, CGB5
46	cycloheximide32	5.6	PDE4A, KIT, VIM, CGA, CGB5, INSR
47	vegf32	5.1	PDE4A, KIT, VIM, MYOG, MUC1, MUC16
48	progesterone32 42 9 18 9	8.9	PDE4A, KIT, LHCGR, SCARB1, MUC16, CGA
49	estrogen32	4.6	MYOG, LHCGR, SCARB1, CGA, CGB, CGB5
50	testosterone32 9 18 9	7.4	KIT, VIM, MYOG, LHCGR, SCARB1, MUC1

Cellular components related to leydig cell tumor according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:005615	7.7	KIT, POMC, THBD, EGF, PTHLH, PTH

Biological processes related to leydig cell tumor according to GeneDecks:

(show all 32)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of male gonad development	GO:2000020	10.6	WT1, NR5A1, SRY
2	cellular response to gonadotropin stimulus	GO:071371	10.6	WT1, CYP17A1, LHCGR
3	phthalate metabolic process	GO:018963	10.6	CYP19A1, CYP17A1, CYP11A1
4	biphenyl metabolic process	GO:018879	10.6	CYP19A1, CYP17A1, CYP11A1
5	dibenzo-p-dioxin metabolic process	GO:018894	10.6	CYP19A1, CYP17A1, CYP11A1
6	progesterone metabolic process	GO:042448	10.5	SRD5A1, AFP, CYP19A1
7	glucocorticoid biosynthetic process	GO:006704	10.5	CYP21A2, CYP17A1, HSD3B1
8	gonad development	GO:008406	10.5	WT1, NR0B1, FSHR, CGA
9	androgen biosynthetic process	GO:006702	10.5	SRD5A1, CYP17A1, HSD3B1, SCARB1
10	response to fungicide	GO:060992	10.4	CYP11A1, CYP17A1, SRD5A1
11	estrogen biosynthetic process	GO:006703	10.4	HSD3B1, CYP11A1, CYP19A1
12	steroid biosynthetic process	GO:006694	10.4	STAR, TSPO, NR0B1, CYP19A1, CYP17A1, HSD3B1
13	hypothalamus development	GO:021854	10.3	NR0B1, SRD5A1, CYP19A1
14	Leydig cell differentiation	GO:033327	10.3	NR0B1, CYP17A1, CYP11A1
15	adrenal gland development	GO:030325	10.3	CYP17A1, TSPO, WT1, PDGFRB, NR5A1, NR0B1
16	hippocampus development	GO:021766	10.3	SRD5A1, CYP19A1, CYP17A1, CYP11A1
17	male genitalia development	GO:030539	10.2	LHCGR, SRD5A1, WT1
18	male sex determination	GO:030238	10.2	NR0B1, SRY, INSR
19	steroid metabolic process	GO:008202	10.1	STAR, TSPO, SRD5A1, CYP21A2, CYP19A1, CYP17A1
20	male gonad development	GO:008584	9.9	WT1, NR5A1, NR0B1, SRD5A1, CYP19A1, INHA
21	peptide hormone processing	GO:016486	9.8	CGA, CGB, POMC
22	cell-cell signaling	GO:007267	9.8	PTHLH, NR5A1, POMC, PGR, PTH, GNRH1
23	adenylate cyclase-activating G-protein coupled receptor signaling pathway	GO:007189	9.7	PTHLH, PTH, GNAL, FSHR
24	positive regulation of glycogen biosynthetic process	GO:045725	9.4	INSR, IGF2, PTH
25	female pregnancy	GO:007565	9.4	PRL, THBD, PTHLH, GNRH1, GNAS
26	positive regulation of mitosis	GO:045840	9.3	EGF, PDGFRB, IGF2, INSR
27	spermatogenesis	GO:007283	9.2	ADCY10, PIWIL4, NR0B1, INSL3, FSHR, LHCGR
28	response to drug	GO:042493	9.2	TSPO, CREB1, SRD5A1, CYP19A1, CYP17A1, CYP11A1
29	small molecule metabolic process	GO:044281	9.1	CYP19A1, CYP21A2, SRD5A1, CRAT, STAR, POMC
30	peptidyl-tyrosine phosphorylation	GO:018108	8.8	EGF, PDGFRB, INSR, KIT
31	positive regulation of cell proliferation	GO:008284	8.2	PROK1, EGF, WDR77, PDGFRB, PTHLH, IGF2
32	signal transduction	GO:007165	7.9	PGR, POMC, EGF, PDGFRB, CREB1, TNFSF14

Molecular functions related to leydig cell tumor according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cholesterol binding	GO:015485	9.9	CYP11A1, TSPO, SYP, STAR
2	steroid hormone receptor activity	GO:003707	9.8	PGR, NR5A2, NR5A1, NR0B1, ESR1
3	receptor binding	GO:005102	9.6	POMC, PDGFRB, CRAT, TNFSF14, INSL3, INHA
4	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity	GO:003705	9.6	CREB1, NR5A2, NR5A1, SRY, PTH
5	hormone activity	GO:005179	8.4	CGA, POMC, PRL, PTHLH, PTH, GNRH1
6	protein binding	GO:005515	4.2	PIWIL1, CREB1, NR5A2, NR5A1, NR0B1, SRY