MCID: LYD001
MIFTS: 46

Leydig Cell Tumor malady

Summaries for Leydig Cell Tumor

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64Wikipedia, 33MalaCards
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Wikipedia:64 Leydig cell tumour, also Leydig cell tumor (US spelling), (testicular) interstitial cell tumour and... more...

MalaCards: Leydig Cell Tumor, also known as leydig cell neoplasm, is related to sertoli-leydig cell tumor and sertoli cell tumor. An important gene associated with Leydig Cell Tumor is DICER1 (dicer 1, ribonuclease type III), and among its related pathways are Mineralocorticoid biosynthesis and Metabolism of steroid hormones and vitamin D. The compounds estrogen and dmrt have been mentioned in the context of this disorder. Related mouse phenotypes are endocrine/exocrine gland and tumorigenesis.

Aliases & Classifications for Leydig Cell Tumor

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 40NCIt, 57SNOMED-CT, 35MeSH
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Aliases & Descriptions:

leydig cell tumor 8 10 45 61
leydig cell neoplasm 8


External Ids:

Disease Ontology8 DOID:2696
NCIt40 C3188
SNOMED-CT57 189739005, 45002009
MeSH35 D007984

Related Diseases for Leydig Cell Tumor

Sources:
17GeneCards, 18GeneDecks
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Diseases in the Leydig Cell Tumor family:

malignant leydig cell tumor

Diseases related to Leydig Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 156)
idRelated DiseaseScoreTop Affiliating Genes
1sertoli-leydig cell tumor31.7PGR, INHA, MUC1, AFP, WT1, CALB2
2sertoli cell tumor31.7PGR, CALB2, MUC1, CYP19A1, INHA
3gynecomastia30.9SRY, PGR, INHA, CYP17A1, CYP19A1
4congenital adrenal hyperplasia30.7CYP19A1, NR0B1, CYP17A1, SRY, NR5A1, HSD3BP4
5androgen insensitivity syndrome30.7SRY
6precocious puberty30.6NR0B1, CYP21A2, CYP19A1, LHCGR
7hyperandrogenism30.6HSD3BP4, LHCGR, CYP19A1, CYP17A1, CYP21A2, INSL3
8cystadenoma30.5INHA, KRT7
9adrenal rest tumor30.5NR5A1, CYP21A2
10klinefelter's syndrome30.5CYP21A2, NR0B1, NR5A1, INHA, CYP19A1
11amenorrhea30.4SRY
12cushing's syndrome30.4CYP21A2, HSD3BP4, LHCGR, NR0B1, CYP17A1, INHA
13adenocarcinoma30.4INHA, NR5A1, CYP21A2, PGR, KRT7, MUC1
14adenoma30.4CYP17A1, NR0B1, KRT7, HSD3BP4, LHCGR, CALB2
15adrenal adenoma30.2CYP17A1, CYP21A2, CYP19A1
16desmoplastic small round cell tumor30.2MUC1, WT1
17dysgerminoma30.2WT1, AFP, INHA, KRT7, SRY
18cryptorchidism30.2NR5A1, INSL3, WT1, CYP19A1, SRY
19infertility30.2CYP19A1, CYP21A2, HSD3BP4, INHA, INSL3, NR5A1
20testicular leydig cell tumor10.8
21hypercalcemia10.6
22virilizing ovarian tumor10.5
23malignant sertoli-leydig cell tumor10.4
24complete androgen insensitivity syndrome10.4
25teratoma10.4
26ovarian malignant sertoli-leydig cell tumor10.4
27malignant testicular leydig cell tumor10.4
28t cell deficiency10.4
29goiter, multinodular 1, with or without sertoli-leydig cell tumors10.4
30multinodular goiter10.3
31malignant sertoli cell tumor10.3
32germ cell tumors10.3
33rete testis adenocarcinoma10.1
34unilateral retinoblastoma10.1
35renal agenesis10.1
36tuberous sclerosis10.1
37mucinous adenocarcinoma10.1
38ollier disease10.1
39b cell deficiency10.1
40breast adenoma10.1
41young syndrome10.1
42gynandroblastoma10.1
43pituitary tumors10.1
44erythrocytosis10.1
45testicular germ cell tumor10.1
46mixed germ cell tumor10.1
47hematopoietic stem cell transplantation10.1
48cystic nephroma10.0DICER1
49adrenocortical carcinoma10.0NR5A1
50premature ovarian failure10.0INHA

Graphical network of the top 20 diseases related to Leydig Cell Tumor:



Diseases related to leydig cell tumor

Clinical Features for Leydig Cell Tumor

Drugs & Therapeutics for Leydig Cell Tumor

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Leydig Cell Tumor

Anatomical Context for Leydig Cell Tumor

Animal Models for Leydig Cell Tumor or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Leydig Cell Tumor

Sources:
51PubMed
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Articles related to Leydig Cell Tumor:

(show top 50)    (show all 392)
idTitleAuthorsYear
1
Cinacalcet attenuates hypercalcemia observed in mice bearing either Rice H-500 Leydig cell or C26-DCT colon tumors. (23623934)
2013
2
Malignant ovarian Sertoli-Leydig cell tumor localized with selective ovarian vein sampling. (23084689)
2012
3
A rare cause of hypertestosteronemia in a 68-year-old patient: a Leydig cell tumor due to a somatic GNAS (guanine nucleotide-binding protein, alpha-stimulating activity polypeptide 1)-activating mutation. (22016347)
2012
4
Retiform Sertoli-Leydig cell tumor of ovary in a 9-year-old girl: case report and review of the literature. (21347632)
2011
5
Malignant Leydig-cell tumor of the testis diagnosed by fine-needle aspiration using ThinPrep technique. (20730900)
2011
6
A rare ovarian Leydig cell tumor (hilar type) causing virilization in a postmenopausal woman. (22053675)
2011
7
DICER1 mutations in familial multinodular goiter with and without ovarian Sertoli-Leydig cell tumors. (21205968)
2011
8
Incidental detection of Sertoli-Leydig cell tumor by FDG PET/CT imaging in a patient with androgen insensitivity syndrome. (19957213)
2010
9
Bilateral Sertoli-Leydig cell tumor of the ovary: a rare case report. (19136796)
2009
10
Inhibition of cyclooxygenase-2 down-regulates aromatase activity and decreases proliferation of Leydig tumor cells. (19679653)
2009
11
Retiform pattern of Sertoli-Leydig cell tumor of the ovary in a 4-year-old girl. (19215568)
2009
12
Estradiol plasma levels elevation during follow-up for testicular Leydig-cell tumor is not an unfailing sign of recurrence. (18041368)
2007
13
Cytologic identification of Reinke crystalloids in ovarian Leydig cell tumor. (16740025)
2006
14
A case of Sertoli-Leydig cell tumor in a postmenopausal woman. (16445673)
2006
15
Leydig cell tumor of the testis with histological and immunohistochemical features of malignancy in a 1-year-old boy with isosexual pseudoprecocity. (17041205)
2006
16
Uterine retiform sertoli-leydig cell tumor: report of a case providing additional evidence that uterine tumors resembling ovarian sex cord tumors have a histologic and immunohistochemical phenotype of genuine sex cord tumors. (16175078)
2005
17
Selective ovarian vein sampling to localize a Leydig cell tumor. (16009186)
2005
18
Effects of overexpression of CXCL10 (cytokine-responsive gene-2) on MA-10 mouse Leydig tumor cell steroidogenesis and proliferation. (15590984)
2004
19
Metachronous bilateral leydig cell tumor in a male adult aged 20. (15604587)
2004
20
Extratesticular Leydig cell tumor of the spermatic cord. (14767314)
2004
21
Sertoli Leydig cell tumor with heterologous gastrointestinal epithelium: a case report. (15027740)
2003
22
Ovarian Sertoli-Leydig cell tumor of intermediate differentiation with immature skeletal muscle heterologous elements. (12648187)
2003
23
Pelvic washing cytology of ovarian Sertoli-Leydig-cell tumor with retiform pattern: a case report. (12827712)
2003
24
Inhibitory mechanisms of lead on steroidogenesis in MA-10 mouse Leydig tumor cells. (12647776)
2003
25
Rodent Leydig cell tumorigenesis: a review of the physiology, pathology, mechanisms, and relevance to humans. (10213111)
1999
26
Functional assessment of the calcium messenger system in cultured mouse Leydig tumor cells: regulation of human chorionic gonadotropin-induced expression of the steroidogenic acute regulatory protein. (10098511)
1999
27
Malignant Leydig cell tumor of the testis associated with Klinefelter's syndrome. (10650798)
1999
28
Relaxin-like factor expression in a human ovarian Sertoli-Leydig cell tumor. (10519633)
1999
29
Leydig cell tumor of the testis: a cytohistological, immunohistochemical, and ultrastructural case study. (9099550)
1997
30
Sertoli-Leydig cell tumor of the ovary: a clinicopathologic study of 10 cases. (8750520)
1996
31
Factors underlying the variability of lipid droplet fluorescence in MA-10 Leydig tumor cells. (7835165)
1994
32
Luteinizing hormone secretory pattern before and after removal of Leydig cell tumor of the testis. (8075784)
1994
33
The use of genetic manipulation of MA-10 Leydig tumor cells to demonstrate the role of mitochondrial proteins in the acute regulation of steroidogenesis. (8382603)
1993
34
A cholesteryl ester hydrolase inhibitor blocks cholesterol translocation into the mitochondria of MA-10 Leydig tumor cells. (1332853)
1992
35
Effects of steroidogenesis inducing protein (SIP) on steroid production in MA-10 mouse Leydig tumor cells: utilization of a non-cAMP second messenger pathway. (1316853)
1992
36
Sebum measurements for rapid identification of hyperandrogenism due to an ovarian Leydig cell tumor. (2050456)
1991
37
Leydig cell tumor of the testis: a case diagnosed by fine-needle sampling without aspiration with histologic, immunohistologic, and electron microscopic analysis. (1769288)
1991
38
Viralization due to Leydig cell tumor diagnosis by magnetic resonance imaging. Case management report. (2376100)
1990
39
Interstitial Leydig cell tumor of testis. (4071875)
1985
40
AFP-producing Sertoli-Leydig cell tumor of the ovary. (2409934)
1985
41
A transplantable rat Leydig cell tumor--2. Adenylyl cyclase activation by prostaglandin E1, isoproterenol and glucagon. (6542613)
1984
42
The hypercalcemic rat Leydig cell tumor--a model of the humoral hypercalcemia of malignancy. (6871760)
1983
43
Metastatic Sertoli-Leydig cell tumor of the ovary during pregnancy treated by BV-CAP chemotherapy. (6177244)
1982
44
Quantitative changes in estrogen receptor produced by chronic DES treatment of two mouse strains differing in susceptibility to Leydig cell tumor induction. (7201547)
1982
45
Lipid composition and gonadotropin-mediated lipid metabolism of the M5480 murine Leydig cell tumor. (7441057)
1980
46
Steroidogenesis in HCG-responsive Leydig cell tumor variants. (314019)
1979
47
Malignant Leydig cell tumor in a 94-year-old man. (470029)
1979
48
Electron microscopy of a feminizing Leydig cell tumor of the testis. (200549)
1977
49
Estrogen-induced Leydig cell tumor in the mouse: a model system for the study of carcinogenesis and hormone dependency. (11351)
1976
50
Estrogenic Leydig-cell tumor with multiple metastases in a dog; the problem of bisexual hormone production by gonadal cells. (13367157)
1956

Genetic Variations for Leydig Cell Tumor

Expression for genes affiliated with Leydig Cell Tumor

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Leydig Cell Tumor

Search GEO for disease gene expression data for Leydig Cell Tumor.

Pathways for genes affiliated with Leydig Cell Tumor

Sources:
54Reactome, 38NCBI BioSystems Database, 30KEGG
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Compounds for genes affiliated with Leydig Cell Tumor

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience, 2BitterDB
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Compounds related to Leydig Cell Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 96)
idCompoundScoreTop Affiliating Genes
1estrogen4510.7CALB2, NR5A1, MYOG
2dmrt4510.7SRY, NR0B1, NR5A1, WT1
3leuprolide acetate4510.7PGR, CYP19A1, LHCGR, CYP21A2
4clomiphene citrate4510.7CYP21A2, CYP19A1, PGR, AFP
5forskolin45 50 1112.7CYP17A1, MYOG, WT1, LHCGR
6butyrate4510.7MYOG, CALB2
7pcb 1264510.7CYP19A1, CYP17A1, CYP21A2
817-hydroxyprogesterone45 2411.6CYP21A2, CYP19A1, CYP17A1, HSD3BP4
9dehydroepiandrosterone sulfate4510.6CYP17A1, CYP21A2, CYP19A1, NR5A1, HSD3BP4
10diethylstilbestrol45 29 1112.6NR5A1, CYP17A1, AFP, PGR, INSL3, CYP19A1
11dhea4510.6HSD3BP4, CYP19A1, NR5A1, CYP17A1, CYP21A2
12androstenedione45 2411.6HSD3BP4, CYP19A1, CYP17A1, INHA, CYP21A2
13b 7234510.6CALB2, AFP, MUC1, WT1, KRT7
14steroidal4510.6HSD3BP4, CYP17A1, PGR, CYP19A1
1517beta-hydroxysteroid4510.6CYP21A2, HSD3BP4, NR5A1, CYP17A1, CYP19A1, PGR
1617-hydroxypregnenolone4510.6HSD3BP4, CYP21A2, CYP17A1
17goserelin45 29 1112.6PGR, CYP19A1, LHCGR
18estrone45 29 11 2413.6AFP, HSD3BP4, PGR, CYP17A1, NR5A1, CYP19A1
19doca4510.6CYP17A1, HSD3BP4, CYP21A2
20ketoconazole45 29 11 2413.6CYP21A2, CYP17A1, HSD3BP4, CYP19A1
21progestin4510.6CYP19A1, MUC1, CYP17A1, PGR, LHCGR, HSD3BP4
22dihydrotestosterone45 29 11 2413.6MUC1, SRY, CYP19A1, PGR, CYP21A2, CYP17A1
23mifepristone45 60 29 1113.6AFP, CYP19A1, PGR, MUC1, HSD3BP4
24dexamethasone45 50 29 1113.5CYP21A2, HSD3BP4, CYP17A1, NR0B1, AFP
25gnrh4510.5CYP19A1, CYP17A1, CYP21A2, INHA, PGR, NR5A1
26acth4510.5CYP17A1, MUC1, NR0B1, NR5A1, CYP21A2, INHA
27buserelin45 29 1112.5LHCGR, CYP19A1, PGR
28hematoxylin4510.5KRT7, INHA, MUC1, CALB2
29mucicarmine4510.5KRT7, MUC1, CALB2
303beta-hydroxysteroid4510.5PGR, INHA, CYP21A2, CYP17A1, CYP19A1, NR5A1
31cyclic amp45 2411.4NR0B1, HSD3BP4, LHCGR, INSL3, INHA, CYP17A1
32paraffin4510.4WT1, AFP, CALB2, MUC1, PGR, KRT7
33cholesterol45 29 11 2413.4NR5A1, HSD3BP4, LHCGR, CYP21A2, CYP17A1, MUC1
34methotrexate45 50 1112.4KRT7, AFP, PGR, CYP19A1, MUC1
35cysteine4510.4MUC1, MYOG, NR0B1, SRY, PGR
36oligonucleotide4510.4CYP17A1, CYP21A2, WT1, AFP, SRY, MYOG
37threonine4510.4NR5A1, CYP21A2, CYP17A1, LHCGR, MUC1, WT1
38ribonucleic acid4510.4CYP17A1, LHCGR, WT1, NR5A1, MYOG, HSD3BP4
39retinoic acid45 2411.4MUC1, KRT7, PGR, CYP17A1, CYP19A1, MYOG
40estradiol45 11 2412.4CYP19A1, HSD3BP4, AFP, SRY, PGR, INHA
41chloramphenicol45 2 1112.3AFP, WT1, MUC1, CYP17A1, CYP21A2
42exemestane50 45 60 1113.3CYP19A1, PGR, CYP17A1
43bisphenol a4510.3CYP19A1, CYP17A1, PGR
44tyrosine4510.2MUC1, KRT7, SRY, CALB2, CYP21A2, AFP
45progesterone45 60 29 11 2414.2CYP21A2, PGR, KRT7, CYP17A1, CYP19A1, MUC1
46vegf4510.1WT1, PGR, MUC1, MYOG, AFP, KRT7
47steroid4510.1MYOG, NR0B1, NR5A1, AFP, WT1, CALB2
48testosterone45 60 11 2413.0CALB2, SRY, KRT7, PGR, INSL3, INHA
49serine459.9AFP, LHCGR, NR5A1, SRY, CYP21A2, CYP17A1
50zinc45 2410.8CYP17A1, SRY, NR0B1, NR5A1, AFP, WT1

GO Terms for genes affiliated with Leydig Cell Tumor

Sources:
16Gene Ontology
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Biological processes related to Leydig Cell Tumor according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of male gonad developmentGO:200002010.6SRY, NR5A1, WT1
2cellular response to gonadotropin stimulusGO:07137110.6LHCGR, WT1, CYP17A1
3sterol metabolic processGO:01612510.6CYP21A2, CYP17A1, CYP19A1
4negative regulation of female gonad developmentGO:200019510.6NR5A1, WT1
5adrenal gland developmentGO:03032510.5NR0B1, WT1, NR5A1, CYP17A1
6steroid biosynthetic processGO:00669410.5NR0B1, CYP19A1, CYP17A1
7progesterone metabolic processGO:04244810.5CYP17A1, AFP
8steroid metabolic processGO:00820210.5CYP21A2, CYP19A1, CYP17A1
9ovulation from ovarian follicleGO:00154210.4AFP, PGR
10glucocorticoid biosynthetic processGO:00670410.4CYP21A2, CYP17A1
11male gonad developmentGO:00858410.4NR5A1, NR0B1, INHA, INSL3, LHCGR, SRY
12Leydig cell differentiationGO:03332710.4CYP17A1, NR0B1
13cell-cell signalingGO:00726710.2INSL3, INHA, NR5A1, PGR
14male sex determinationGO:03023810.1SRY, NR0B1

Molecular functions related to Leydig Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:00510210.3PGR, INSL3, INHA, TNFSF14
2ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:00487910.2NR5A1, NR0B1, PGR
3steroid hormone receptor activityGO:00370710.0PGR, NR5A1, NR0B1

Products for genes affiliated with Leydig Cell Tumor

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Sources for Leydig Cell Tumor

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet