Aliases & Classifications for Leydig Cell Tumor

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Sources:
10Disease Ontology, 47Novoseek, 12DISEASES, 65UMLS, 36MeSH, 59SNOMED-CT, 42NCIt
See all sources

Aliases & Descriptions for Leydig Cell Tumor:

Name: Leydig Cell Tumor 10 47 12 65 36
 
Leydig Cell Neoplasm 10


Classifications:



External Ids:

Disease Ontology10 DOID:2696
MeSH36 D007984
SNOMED-CT59 189739005, 45002009
NCIt42 C3188

Summaries for Leydig Cell Tumor

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MalaCards based summary: Leydig Cell Tumor, also known as leydig cell neoplasm, is related to prostate cancer and sertoli-leydig cell tumor. An important gene associated with Leydig Cell Tumor is LHCGR (Luteinizing Hormone/Choriogonadotropin Receptor), and among its related pathways are Estrone metabolism and Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics. Affiliated tissues include testis, ovary and testes, and related mouse phenotypes are adipose tissue and growth/size/body.

Related Diseases for Leydig Cell Tumor

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Diseases in the Leydig Cell Tumor family:

Malignant Leydig Cell Tumor

Diseases related to Leydig Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 131)
idRelated DiseaseScoreTop Affiliating Genes
1prostate cancer29.4CYP17A1, CYP19A1, ESR1, INHA, PTHLH
2sertoli-leydig cell tumor11.2
3testicular leydig cell tumor10.8
4malignant leydig cell tumor10.8
5gynecomastia10.7
6goiter, multinodular 1, with or without sertoli-leydig cell tumors10.6
7hypercalcemia10.6
8congenital adrenal hyperplasia10.6
9hyperandrogenism10.5
10malignant sertoli-leydig cell tumor of ovary10.5
11androgen insensitivity10.5
12complete androgen insensitivity syndrome10.5
13precocious puberty10.5
14malignant testicular leydig cell tumor10.5
15sarcoma10.5
16cryptorchidism10.4
17malignant sertoli-leydig cell tumor10.4
18multinodular goiter10.4
19cystadenoma10.4
20adrenal rest tumor10.4
21cervicitis10.4
22goiter10.4
23rhabdomyosarcoma10.4
24teratoma10.4
25amenorrhea10.3
26adenocarcinoma10.3
27adenoma10.3
28mature teratoma10.3
29penoscrotal transposition10.3CYP17A1, LHCGR
30ovary adenocarcinoma10.2INHA, PTHLH
31mixed germ cell-sex cord neoplasm10.2AFP, INHA
32hepatocellular clear cell carcinoma10.2AFP, PTHLH
33ovarian endometrioid adenofibroma10.2AFP, INHA
34adrenal hyperplasia, congenital, due to 21-hydroxylase deficiency10.2CYP21A2, INHA
35ovarian gonadoblastoma10.2AFP, INHA
36long bone adamantinoma10.2AFP, PTHLH
37dcx-related disorders10.2CYP17A1, CYP21A2
38gastric hemangioma10.2AFP, PTHLH
39cystic kidney10.2AFP, INHA
40hemangioma of lung10.2AFP, PTHLH
41breast cancer10.2
42retinoblastoma10.2
43alopecia10.2
44hematopoietic stem cell transplantation10.2
45islet cell tumor10.2
46rete testis adenocarcinoma10.2
47sertoli cell tumor10.2
48tuberous sclerosis10.2
49klinefelter's syndrome10.2
50neuroectodermal tumor10.2

Graphical network of the top 20 diseases related to Leydig Cell Tumor:



Diseases related to leydig cell tumor

Symptoms for Leydig Cell Tumor

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Drugs & Therapeutics for Leydig Cell Tumor

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Drugs for Leydig Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
MetforminapprovedPhase 41573657-24-9, 1115-70-414219, 4091
Synonyms:
1,1-Dimethyl biguanide
1,1-Dimethylbiguanide
3-(diaminomethylidene)-1,1-dimethylguanidine
657-24-9
AC1L1HE4
AKOS000121065
Apo-Metformin
BIDD:GT0697
BPBio1_000009
BRD-K79602928-003-04-1
BSPBio_000007
BSPBio_002314
C07151
C4H11N5
CAS-1115-70-4
CCRIS 9321
CHEBI:6801
CHEMBL1431
CID4091
D04966
DB00331
DMBG
DMGG
Diabefagos
Diabetosan
Diabex
Diaformin
Dianben
Dimethylbiguanid
Dimethylbiguanide
Dimethylbiguanidine
Dimethyldiguanide
Dimethylguanylguanidine
EINECS 211-517-8
Fluamine
Flumamine
Fortamet
Gen-Metformin
Glifage
Gliguanid
Glucophage
Glucophage XR
Glumetza
Glycon
HMS2089D19
HSCI1_000295
Haurymelin
Haurymellin
Islotin
KBio2_002310
KBio2_004878
KBio2_007446
KBio3_002790
KBioGR_002310
 
KBioSS_002312
LA-6023
LS-43899
Meguan
Melbin
Metformin
Metformin (USAN/INN)
Metformin HCL
Metformin Hydrochloride
Metformin [USAN:INN:BAN]
Metformina
Metformina [DCIT]
Metformina [Spanish]
Metformine
Metformine [INN-French]
Metformine pamoate
Metforminum
Metforminum [INN-Latin]
Metiguanide
MolPort-002-929-560
MolPort-004-288-389
MolPort-005-767-418
Mylan-Metformin
N,N-Dimethylbiguanide
N,N-Dimethyldiguanide
N,N-Dimethylimidodicarbonimidic diamide
N,N-dimethylimidodicarbonimidic diamide
N1,N1-Dimethylbiguanide
NCGC00016564-01
NCGC00016564-02
NCGC00016564-03
NNDG
Novo-Metformin
Nu-Metformin
Obimet
PMS-Metformin
Prestwick0_000004
Prestwick1_000004
Prestwick2_000004
Prestwick3_000004
Ran-Metformin
Ratio-Metformin
Riomet
S2483_Selleck
SPBio_001928
STK011633
Sandoz Metformin
Siofor
T5895664
Teva-Metformin
UNII-9100L32L2N
ZINC12859773
cMAP_000016
metformin
metformin hydrochloride
2
SimvastatinapprovedPhase 448279902-63-954454
Synonyms:
(+)-Simvastatin
(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate
2,2-Dimethylbutanoic acid (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester
2,2-Dimethylbutyric acid, 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one
2,2-Dimethylbutyric acid, 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8ar)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one
79902-63-9
AC-1530
AC1L1H1F
AKOS005111006
ARONIS24119
BCBcMAP01_000007
BIDD:GT0769
BPBio1_001001
BRD-K22134346-001-05-8
BRN 4768037
BSPBio_000909
BSPBio_002337
Bio-0672
Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,*aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-((2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester
Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-((2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester
Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester
C25H38O5
CCRIS 7558
CHEBI:9150
CHEMBL1064
CID54454
CPD000718785
Cholestat
Coledis
Colemin
Corolin
D00434
D019821
DRG-0320
Denan
DivK1c_006991
Eucor
HMS1570N11
HMS1922H13
HMS2089D12
HMS2093E06
HSDB 7208
InChI=1/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1
KBio1_001935
KBio2_002197
KBio2_004765
KBio2_007333
KBio3_001557
KBioGR_001244
KBioSS_002197
KS-1113
Kolestevan
L 644128-000U
LS-46264
Labistatin
Lipex
Lipinorm
Liponorm
Lipovas
Lodales
MK 0733
MK 733
MK-0733
MK-733
MK733
MLS001304029
MLS001333077
MLS001333078
 
MLS002154038
Medipo
Modutrol
MolPort-002-507-345
MolPort-002-885-862
NCGC00017324-01
NCGC00017324-02
NCGC00017324-03
Nivelipol
Nor-Vastina
Pantok
Pepstatin
Prestwick0_000865
Prestwick1_000865
Prestwick2_000865
Prestwick3_000865
Prestwick_171
Rechol
Rendapid
S1792_Selleck
S6196_SIGMA
SAM002589969
SMR000718785
SPBio_001881
SPBio_002830
SPECTRUM1504236
STK801938
Simcor
Simovil
Simvast CR
Simvastatin
Simvastatin & Primycin
Simvastatin (JAN/USP/INN)
Simvastatin [USAN:INN:BAN]
Simvastatin [Usan:Ban:Inn]
Simvastatin lactone
Simvastatin, Compactin
Simvastatina
Simvastatina [Spanish]
Simvastatine
Simvastatine [French]
Simvastatinum
Simvastatinum [Latin]
Simvotin
Sinvacor
Sinvascor
Sivastin
SpecPlus_000895
Spectrum2_001671
Spectrum3_000669
Spectrum4_000632
Spectrum5_001428
Spectrum_001717
Statin
Synvinolin
TNP00259
UNII-AGG2FN16EV
Valemia
Vasotenal
Velostatin
Vytorin
ZINC03780893
Zocor
Zocor (TN)
Zocor, Simlup, Simcard, Simvacor, Simvoget, Zorced, Simvastatin
Zocord
[(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate
butanoic acid, 2,2-dimethyl-,1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)-ethyl]-1-naphthalenyl ester, [1S-[1 alpha,3 alpha,7 beta,8 beta(2S*,4S*),-8a beta
nchembio790-comp16
simvastatin
3
Testosteroneapproved, investigationalPhase 2, Phase 345358-22-06013
Synonyms:
(+)-testosterone
(+-)-8-iso-testosterone
(+-)-retrotestosterone
(+-)-testosterone
(17b)-17-hydroxy-androst-4-en-3-one
(17beta)-17-Hydroxyandrost-4-en-3-one
(8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
13-Iso-testosterone
17-Hydroxy-(17-beta)-androst-4-en-3-one
17-Hydroxy-(17beta)-androst-4-en-3-one
17-Hydroxy-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one
17-Hydroxy-D4-androsten-3-one
17-Hydroxy-androst-4-en-3-one
17-beta-Hydroxy-delta(sup 4)-androsten-3-one
17-beta-Hydroxyandrost-4-en-3-one
17?-Hydroxy-4-androsten-3-one
17a-Hydroxy-(13a)-androst-4-en-3-one
17a-Hydroxy-13a-androst-4-en-3-one
17a-Hydroxy-14b-androst-4-en-3-one
17a-Hydroxy-androst-4-en-3-one
17b-Hydroxy-(10a)-androst-4-en-3-one
17b-Hydroxy-(13a)-androst-4-en-3-one
17b-Hydroxy-(8a)-androst-4-en-3-one
17b-Hydroxy-(8a,10a)-androst-4-en-3-one
17b-Hydroxy-(9b)-androst-4-en-3-one
17b-Hydroxy-(9b,10a)-androst-4-en-3-one
17b-Hydroxy-13a-androst-4-en-3-one
17b-Hydroxy-8a-androst-4-en-3-one
17b-Hydroxy-D4-androsten-3-one
17b-Hydroxy-androst-4-en-3-on
17b-Hydroxy-androst-4-en-3-one
17b-Hydroxyandrost-4-en-3-one
17b-Hydroxyandrost-4-ene-3-one
17b-Testosterone
17b-hydroxy-4-androsten-3-one
17beta-Hydroxy-3-oxo-4-androstene
17beta-Hydroxy-4-androsten-3-one
17beta-Hydroxy-delta(sup4)-androsten-3-one
17beta-Hydroxyandrost-4-en-3-one
17beta-Hydroxyandrost-4-ene-3-one
17beta-hydroxy-4-androsten-3-one
4-Androsten-17?-ol-3-one
4-Androsten-17beta-ol-3-one
4-Androsten-3-one-17b-ol
4-androsten-17β-ol-3-one
4-androstene-17beta-ol-3-one
46923_FLUKA
46923_RIEDEL
58-22-0
7-beta-Hydroxyandrost-4-en-3-one
8-Iso-testosterone
9b,10a-Testosterone
9b-Testosterone
AA 2500
AC-14899
AC1L1LM0
Andro 100
AndroGel
Androderm
Androderm (TN)
Androgel
Androgel (TN)
Androlin
Andronaq
Andronate 100
Andronate 200
Andropatch
Andropository 200
Androsorb
Androst-4-en-17b-ol-3-one
Androst-4-en-17beta-ol-3-one
Androst-4-ene-17b-ol-3-one
Andrusol
Andryl 200
Aveed
Axiron
B5DEE83F-632B-48A1-A0ED-A51E7F13DF2E
BIDD:ER0555
BIM-0061761.0001
Bio-0678
C00535
CCRIS 574
CDB 111C
CHEBI:17347
CHEMBL386630
CID6013
CMC_13449
COL 1621
CP 601B
CPD000058344
Cristerona T
Cristerone T
D00075
D4-Androsten-17b-ol-3-one
DB00624
Delatestryl
Depo-Testadiol
Depo-testosterone
Depotest
EINECS 200-370-5
Epitestosteron
Everone 200
Fortesta
Geno-cristaux Gremy
Geno-cristaux gremy
HMS2052N11
HSDB 3398
Halotensin
Homosteron
Homosterone
 
Intrinsa
LMST02020002
LS-148813
LibiGel
Lumitestosteron
MLS000563091
MLS001032098
MLS001306401
MLS002174283
Malerone
Malestrone (amps)
Malogen in Oil
Malogen, aquaspension injection
Mertestate
MolPort-002-506-901
NCGC00091018-01
NSC 9700
Natesto nasal gel
Neo-Hombreol F
Neo-testis
Neotestis
Oreton
Oreton F
Oreton-F
Orquisteron
Perandren
Percutacrine androgenique
Primotest
Primoteston
Rac-17b-hydroxy-(13a)androst-4-en-3-one
Rac-17b-hydroxy-(8a)-androst-4-en-3-one
Rac-17b-hydroxy-(9b,10a)androst-4-en-3-one
Rac-17b-hydroxy-androst-4-en-3-one
Relibra
Retrotestosterone
S00309
S2033_Selleck
SAM001246921
SMR000058344
SMR001261453
Scheinpharm Testone-Cyp
Striant
Striant (TN)
Sustanon
Sustanone
Sustason 250
Synandrol F
T-Cypionate
T1500_SIGMA
T5411_FLUKA
T5411_SIGMA
Teslen
Testamone 100
Testandrone
Testaqua
Testiculosterone
Testim
Testim (TN)
Testobase
Testoderm
Testoderm Tts
Testogel
Testoject-50
Testolent
Testolin
Testopel
Testopel Pellets
Testopropon
Testosteroid
Testosteron
Testosterona
Testosterona [INN-Spanish]
Testosterone
Testosterone (JAN/USP)
Testosterone Enanthate
Testosterone Gel
Testosterone Heptanoate
Testosterone Propionate
Testosterone Undecanoate
Testosterone [Androgenic steroids, anabolic]
Testosterone [INN:BAN]
Testosterone and its esters
Testosterone hydrate
Testosterone solution
Testosteronum
Testosteronum [INN-Latin]
Testostosterone
Testostérone
Testoviron
Testoviron Schering
Testoviron T
Testoxyl
Testred Cypionate 200
Testrin-P.A
Testro AQ
Testrone
Testryl
Tostrelle
Tostrex
UNII-3XMK78S47O
Viatrel
Virilon IM
Virormone
Virosterone
Vogelxo
ZINC06500184
beta testosterone
delta(sup 4)-Androsten-17(beta)-ol-3-one
delta4-Androsten-17beta-ol-3-one
delta4-androsten-17b-ol-3-one
trans-Testosterone
4
MethyltestosteroneapprovedPhase 2, Phase 345358-18-46010
Synonyms:
17(alpha)-Methyl-delta(4)-androsten-17(beta)-ol-3-one
17-Methyltestosterone
17-beta-Hydroxy-17-methylandrost-4-en-3-one
17-methyltestosterone
17alpha-Methyl-3-oxo-4-androsten-17beta-ol
17alpha-Methyl-delta(4)-androsten-17beta-ol-3-one
17alpha-Methyltestosterone
17alpha-methyl-delta-androsten-17beta-ol-3-one
17alpha-methyltestosterone
17beta-Hydroxy-17-methylandrost-4-en-3-one
 
17α-methyl-Δ4-androsten-17β-ol-3-one
17α-methyltestosterone
4-Androstene-17alpha-methyl-17beta-ol-3-one
Android
Methitest
Methyltestosterone
Methyltestosteronum
Metiltestosterona
NSC-9701
Testred
Testred C-III
Virilon
5
Testosterone enanthatePhase 2, Phase 3453315-37-79416
Synonyms:
17-((1-Oxoheptyl)oxy)androst-4-en-3-one
17-Hydroxyandrost-4-en-3-one, 17-heptanoate
17-Hydroxyandrost-4-en-3-one, 17-heptanoic acid
17beta-Enanthoxyandrost-4-en-3-one
17beta-Hydroxyandrost-4-en-3-one enanthate
4-Androsten-17beta-ol-3-one 17-enanthate
4-Androsten-3-one 17beta-enanthate
Androgyn L.A.
Andropository
Androtardyl
Atlatest
DEA No. 4000
DePatestrye
Delatest
Delatestryl
Depo-Testro Med
Ditate
Durathate
Everone
 
Exten test
Malogen L.A.
Malogen L.A.200
Orquisteron-E
Primotestone
Reposo TMD
Testanthate
Testate
Testenate
Testinon
Testoenant
Testonenant
Testosterone 17-enanthate
Testosterone 17beta-heptanoate
Testosterone 17beta-heptanoic acid
Testosterone enantate
Testosterone heptoate
Testosterone heptoic acid
Testosterone heptylate
Testosterone oenanthate
Testostroval
6Testosterone undecanoatePhase 2, Phase 3453
7CatharticsPhase 2, Phase 3278
8Testosterone 17 beta-cypionatePhase 2, Phase 3457
9Castor OilPhase 2, Phase 320
10LaxativesPhase 2, Phase 3278
11CastorNutraceuticalPhase 2, Phase 321
12
GemcitabineapprovedPhase 1180095058-81-460750
Synonyms:
103882-84-4
122111-03-9
2',2'-DiF-dC
2',2'-Difluoro-2'-deoxycytidine
2',2'-Difluorodeoxycytidine
2'-Deoxy-.beta.-D-2',2'-difluorocytidine
2'-Deoxy-2',2'-difluorocytidine
4-Amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
4-Amino-1-[3,3-difluoro-4-hydroxy-5-(hydroxymethyl) tetrahydrofuran-2-yl]-1H-pyrimidin-2-one
4-amino-1-((2R,4R,5R)-3,3-Difluoro-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
4-amino-1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
95058-81-4
AB1004842
AC1L1TUQ
C07650
CCRIS 8984
CHEBI:175901
CHEMBL888
CID60750
Cytidine, 2'-deoxy-2',2'-difluoro-2'-Deoxy-.beta.-D-2',2'-difluorocytidine
D02368
DB00441
DDFC
DFDC
DFdC
DFdCyd
Folfugem
GEO
Gamcitabine
GemLip
Gemcel
 
Gemcin
Gemcitabin
Gemcitabina
Gemcitabina [INN-Spanish]
Gemcitabine
Gemcitabine (USAN/INN)
Gemcitabine HCl
Gemcitabine Hydrochloride
Gemcitabine hydrochloride
Gemcitabine stereoisomer
Gemcitabinum
Gemcitabinum [INN-Latin]
Gemtro
Gemzar
Gemzar (hydrochloride)
HMS2089P10
HSDB 7567
Inno-D07001
LS-59139
LY 188011
LY-188011
LY188011
NCGC00168784-01
NChemBio.2007.10-comp25
NSC 613327
NSC613327
TL8005979
UNII-B76N6SBZ8R
ZINC18279854
Zefei
gemcitabine
nchembio.573-comp7
nchembio.90-comp2
13
CarboplatinapprovedPhase 1181241575-94-410339178, 498142, 38904, 38904, 498142
Synonyms:
(SP-4-2)-diammine[cyclobutane-1,1-dicarboxylato(2-)-kappa(2)O,O']platinum
/h1-3H2,(H,7,8)(H,9,10)
/q
1,1-Cyclobutanedicarboxylate diammine platinum (II)
1,1-Cyclobutanedicarboxylate diammine platinum(II)
2*-1
2*1H2
41575-94-4
70903-55-8
AC-1457
AC1L8I6U
Ambap41575-94-4
BSPBio_003145
C 2538
C2043
C2538_SIGMA
C6H10N2O4Pt
CBDCA
CCRIS 3404
CHEBI:31355
CHEMBL1351
CHEMBL288376
CID10339178
CID2567
CID38904
CID426756
CID498142
CID5352133
CID6398587
CID6603770
Carbopaltin
Carboplatin
Carboplatin (JAN/USP/INN)
Carboplatin (USAN)
Carboplatin [USAN:INN:BAN:JAN]
Carboplatine
Carboplatine [French]
Carboplatino
Carboplatino [Spanish]
Carboplatinum
Carboplatinum [Latin]
Cbdca
Cyclobutane-1,1-dicarboxylate
D01363
DB00958
Diammine(1,1-cyclobutanedicarboxylato)platinum (II)
Diammine(cyclobutane-1,1-dicarboxylato(2-)-O,O')platinum
Diammine-1,1-cyclobutane dicarboxylate platinum II
DivK1c_000892
EINECS 255-446-0
EU-0100230
Ercar
HMS1921J16
HMS2090M05
HMS2092B22
HMS502M14
HSDB 6957
I14-2390
IDI1_000892
IUPAC: Azane
InChI=1/C6H8O4.2H2N.Pt/c7-4(8)6(5(9)10)2-1-3-6
 
JM 8
JM-8
KBio1_000892
KBio2_002009
KBio2_004577
KBio2_007145
KBio3_002645
KBioGR_000713
KBioSS_002009
LS-117689
Lopac-C-2538
Lopac0_000230
MolPort-003-665-501
MolPort-003-845-609
NCGC00015223-01
NCGC00093695-01
NCGC00094961-01
NCGC00094961-02
NCGC00094961-03
NCGC00162099-01
NCGC00162099-02
NCGC00167800-01
NCGC00178242-01
NINDS_000892
NSC 201345
NSC 241240
NSC-241240
NSC201345
NSC241240
Paraplatin
Paraplatin (TN)
Paraplatin, Carboplatin
Paraplatin-AQ
Platinum(+2) Cation
Platinum(II), (1, 1-cyclobutanedicar
Platinum, diammine(1,1-cyclobutanedicarboxylato(2-)-O,O')-, (SP-4-2)
Platinum, {diammine[1,1-cyclobut
S1215_Selleck
SPBio_000716
SPECTRUM1502106
Spectrum2_000898
Spectrum3_001503
Spectrum4_000337
Spectrum5_001094
Spectrum_001529
UNII-BG3F62OND5
azanide
carboplatin
cis -Diammine[1,1-cyclobutane-dicarboxylato] platinum
cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(II)
cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(ii)
cis-Diamine(1,1-cyclobutanedicarboxylato)platinum(II)
cis-Diamine[1,1-cyclobutanedicarboxylato]platinum(II)
cis-Diammine(1,1-cyclobutanedicarboxylato) platinum
cis-Diammine(1,1-cyclobutanedicarboxylato)platinum
cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II)
cis-Diammine(cyclobutanedicarboxylato)platinum II
cyclobutane-1,1-dicarboxylic acid
diammine[cyclobutane-1,1-dicarboxylato(2-)-k2O1,O1]platinum
nchembio.573-comp10
nchembio773-comp2
nchembio873-comp3
platinum(2+)

Interventional clinical trials:

idNameStatusNCT IDPhase
1Effects of Metformin Plus Simvastatin on Polycystic Ovarian Syndrome (PCOS): A Prospective, Randomized, Double-Blind, Placebo-Controlled StudyCompletedNCT01021579Phase 4
2Androgen for Leydig Cell ProliferationCompletedNCT01206270Phase 2, Phase 3
3Carboplatin, Gemcitabine Hydrochloride, and Stereotactic Body Radiation Therapy in Gynecological CancerCompletedNCT01652794Phase 1
4Stress Reduction in Improving Quality of Life in Patients With Recurrent Gynecologic or Breast CancerCompletedNCT01764789
5DICER1-related Pleuropulmonary Blastoma Cancer Predisposition Syndrome: A Natural History StudyRecruitingNCT01247597
6Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer SyndromeRecruitingNCT00565903
7International Ovarian & Testicular Stromal Tumor RegistryRecruitingNCT01970696
8Studying Genes in Samples From Younger Patients With Ovarian or Testicular Sex Cord Stromal TumorsActive, not recruitingNCT01572467

Search NIH Clinical Center for Leydig Cell Tumor


Cochrane evidence based reviews: Leydig Cell Tumor

Genetic Tests for Leydig Cell Tumor

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Anatomical Context for Leydig Cell Tumor

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MalaCards organs/tissues related to Leydig Cell Tumor:

33
Testis, Ovary, Testes, Breast, Pituitary, Endothelial, Skeletal muscle

Animal Models for Leydig Cell Tumor or affiliated genes

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MGI Mouse Phenotypes related to Leydig Cell Tumor:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053759.3CYP19A1, ESR1, LHCGR, PTHLH
2MP:00053787.6CYP11A1, CYP19A1, ESR1, INHA, LHCGR, PTHLH
3MP:00053867.2AFP, CYP11A1, CYP17A1, CYP19A1, ESR1, LHCGR
4MP:00053796.6AFP, CYP11A1, CYP19A1, ESR1, INHA, LHCGR
5MP:00053766.1AFP, CYP11A1, CYP17A1, CYP19A1, ESR1, INHA
6MP:00053895.9AFP, CYP11A1, CYP17A1, CYP19A1, ESR1, INHA

Publications for Leydig Cell Tumor

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Articles related to Leydig Cell Tumor:

(show top 50)    (show all 350)
idTitleAuthorsYear
1
Alopecia and Hirsutism in a Postmenopausal Woman as the Presenting Complaint of Ovarian Hilus (Leydig) Cell Tumor. (25910403)
2015
2
Testicular Leydig Cell Tumor with Metachronous Lesions: Outcomes after Metastasis Resection and Cryoablation. (26525589)
2015
3
Leydig cell tumor incidentally detected by fused FDG-PET/MRI. (25636443)
2015
4
Testicular adrenal rest tumor mimicking leydig cell tumor in a patient with congenital adrenal hyperplasia. (24834391)
2014
5
Bilateral sertoli-leydig cell tumor in a primigravida: a rare case. (25002956)
2014
6
Bilateral laparoscopic gonadectomy in a patient with complete androgen insensitivity syndrome and bilateral sertoli-leydig cell tumor: a case report and brief review of the literature. (25032133)
2014
7
A case of successful salvage chemotherapy of recurrent ovarian sertoli-leydig cell tumor. (24328002)
2013
8
"Occult" ovarian Leydig cell tumor: when laboratory tells more than imaging. (24091542)
2013
9
Cervical sarcoma botryoides and ovarian Sertoli-Leydig cell tumor: a case report and review of literature. (21847587)
2012
10
Leydig cell tumor in two brothers with congenital adrenal hyperplasia due to 11-I^ hydroxylase deficiency: a case report. (21259051)
2012
11
Malignant ovarian Sertoli-Leydig cell tumor localized with selective ovarian vein sampling. (23084689)
2012
12
Leydig cell tumor of the testis. (19303105)
2009
13
Histologic and immunohistochemical characterization of a testicular mixed germ cell sex cord-stromal tumor and a leydig cell tumor in a dog. (18039910)
2007
14
Estrogen receptor alpha and progesterone receptor expression in ovarian adult granulosa cell tumors and Sertoli-Leydig cell tumors. (17885486)
2007
15
A rare ovarian tumor - Sertoli-Leydig cell tumor with heterologous element. (18311394)
2007
16
Sertoli-Leydig cell tumor of ovary with heterologous element: a case report. (16366107)
2005
17
Human endocrine gland-derived vascular endothelial growth factor: expression early in development and in Leydig cell tumors suggests roles in normal and pathological testis angiogenesis. (15292351)
2004
18
Sertoli-Leydig cell tumor of the ovary. (15216408)
2004
19
Pathologic quiz case: patient with testicular pain. Benign Leydig cell tumor. (14692826)
2004
20
A constitutively active somatic mutation of the human lutropin receptor found in Leydig cell tumors activates the same families of G proteins as germ line mutations associated with Leydig cell hyperplasia. (12933660)
2003
21
Absence of activating mutations in the hot spots of the LH receptor and Gs-alpha genes in Leydig cell tumors. (12150333)
2002
22
Male LH-independent sexual precocity in a 3.5-year-old boy caused by a somatic activating mutation of the LH receptor in a Leydig cell tumor. (11889161)
2002
23
Occult Leydig cell tumor in a patient with gynecomastia. (11497478)
2001
24
Elevated levels of inhibin-A and immunoreactive inhibin in aged male Wistar rats with testicular Leydig cell tumor. (11545298)
2001
25
Leydig-cell tumors caused by an activating mutation of the gene encoding the luteinizing hormone receptor. (10580072)
1999
26
Bilateral ovarian stromal hyperplasia concealing a nonhilar, pure stromal-Leydig cell tumor. A case report. (10394554)
1999
27
Leydig cell tumor of the testis: a clinicopathologic, DNA content, and MIB-1 comparison of nonmetastasizing and metastasizing tumors. (9808128)
1998
28
Activating mutation of the stimulatory G protein (gsp) as a putative cause of ovarian and testicular human stromal Leydig cell tumors. (9626141)
1998
29
Presence of 17 beta-hydroxysteroid dehydrogenase type 3 messenger ribonucleic acid transcript in an ovarian Sertoli-Leydig cell tumor. (9314929)
1997
30
Virilizing stromal Leydig cell tumor (Leydig cell-containing thecoma) of the ovary in pregnancy. A case report with extensive immunohistochemical investigation of the tumor cells. (8542508)
1995
31
Immunohistochemical and biochemical analysis of a human Sertoli-Leydig cell tumor: autonomous steroid production characteristic of ovarian theca cells. (9420846)
1995
32
Precocious puberty in a child with unilateral Leydig cell tumor of the testis following orchiopexy. (8105109)
1993
33
Ultrastructure and immunohistochemistry of a fetal-type Leydig cell tumor. (1448884)
1992
34
Isosexual male precocity due to a Leydig cell tumor. (1291502)
1992
35
Treatment of malignant Leydig cell tumor. (1913469)
1991
36
Diagnosis and resection of an oral contraceptive-suppressible Sertoli-Leydig cell tumor with preservation of fertility and a 7-year follow-up. (2523030)
1989
37
Sertoli-Leydig cell tumor associated with a mature cystic teratoma in a single ovary. (2587573)
1989
38
Ovarian Sertoli-Leydig cell tumor with elevated serum alpha-fetoprotein. (2467733)
1989
39
Steroidogenesis-activator polypeptide isolated from a rat Leydig cell tumor. (3563495)
1987
40
The rat LTW(m) Leydig cell tumor: cancer anorexia due to estrogen. (6587964)
1984
41
A transplantable rat Leydig cell tumor: binding properties, hormonal responsiveness, and tumor growth. (6100028)
1984
42
Leydig cell tumor in patient on estrogen therapy. (6857903)
1983
43
Metastatic Sertoli-Leydig cell tumor of the ovary during pregnancy treated by BV-CAP chemotherapy. (6177244)
1982
44
Ultrastructure of a virilizing ovarian Leydig-cell-tumor. Hilar cell tumor. (6293161)
1982
45
Lipid composition and gonadotropin-mediated lipid metabolism of the M5480 murine Leydig cell tumor. (7441057)
1980
46
Steroidogenesis in HCG-responsive Leydig cell tumor variants. (314019)
1979
47
Leydig-cell tumor of the testis with gynecomastia and elevated estrogen levels. (868795)
1977
48
Estrogen-induced Leydig cell tumor in the mouse: a model system for the study of carcinogenesis and hormone dependency. (11351)
1976
49
Sertoli-Leydig cell tumor of the ovary, with an associated mucinous cystadenoma. An ultrastructural and endocrine study. (4280005)
1974
50
Estrogenic Leydig-cell tumor with multiple metastases in a dog; the problem of bisexual hormone production by gonadal cells. (13367157)
1956

Variations for Leydig Cell Tumor

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Expression for genes affiliated with Leydig Cell Tumor

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Search GEO for disease gene expression data for Leydig Cell Tumor.

Pathways for genes affiliated with Leydig Cell Tumor

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Pathways related to Leydig Cell Tumor according to GeneCards Suite gene sharing:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8CYP17A1, CYP19A1
29.6CYP19A1, ESR1
39.4CYP19A1, INHA, LHCGR
4
Show member pathways
9.4CYP17A1, CYP19A1, CYP21A2
59.0CYP11A1, CYP19A1, STAR
6
Show member pathways
8.9CYP11A1, CYP21A2, STAR
78.9CYP11A1, CYP21A2, STAR
8
Show member pathways
8.7CYP11A1, CYP17A1, CYP19A1, CYP21A2
9
Show member pathways
8.7CYP11A1, CYP17A1, CYP19A1, CYP21A2
10
Show member pathways
8.7CYP11A1, CYP17A1, CYP19A1, CYP21A2
118.4CYP11A1, CYP17A1, CYP19A1, LHCGR, STAR
12
Show member pathways
8.2CYP11A1, CYP17A1, CYP19A1, CYP21A2, STAR

GO Terms for genes affiliated with Leydig Cell Tumor

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Cellular components related to Leydig Cell Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial cristaGO:00300619.3CYP11A1, STAR

Biological processes related to Leydig Cell Tumor according to GeneCards Suite gene sharing:

(show all 36)
idNameGO IDScoreTop Affiliating Genes
1adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:000718910.3LHCGR, PTHLH
2uterus developmentGO:006006510.2ESR1, LHCGR
3androgen metabolic processGO:000820910.1CYP19A1, ESR1
4phenol-containing compound metabolic processGO:001895810.0CYP11A1, STAR
5testosterone biosynthetic processGO:006137010.0CYP11A1, STAR
6response to gonadotropinGO:003469810.0CYP11A1, STAR
7cellular response to follicle-stimulating hormone stimulusGO:007137210.0CYP11A1, STAR
8progesterone biosynthetic processGO:00067019.9CYP11A1, STAR
9phthalate metabolic processGO:00189639.9CYP11A1, STAR
10cellular response to peptide hormone stimulusGO:00713759.9CYP11A1, CYP21A2
11response to fungicideGO:00609929.9CYP11A1, STAR
12cellular response to transforming growth factor beta stimulusGO:00715609.9CYP11A1, STAR
13response to insecticideGO:00170859.9CYP11A1, STAR
14response to corticosteroneGO:00514129.9CYP11A1, STAR
15cellular response to antibioticGO:00712369.9CYP11A1, STAR
16response to steroid hormoneGO:00485459.9CYP11A1, STAR
17cellular response to cAMPGO:00713209.9CYP11A1, STAR
18dibenzo-p-dioxin metabolic processGO:00188949.8CYP11A1, STAR
19cellular response to cadmium ionGO:00712769.8CYP11A1, STAR
20biphenyl metabolic processGO:00188799.8CYP11A1, STAR
21organic acid metabolic processGO:00060829.7CYP11A1, STAR
22cellular response to gonadotropin stimulusGO:00713719.7CYP11A1, LHCGR, STAR
23estrogen biosynthetic processGO:00067039.7CYP11A1, CYP19A1, STAR
24glucocorticoid biosynthetic processGO:00067049.6CYP11A1, CYP17A1, CYP21A2
25progesterone metabolic processGO:00424489.5AFP, CYP17A1, CYP21A2
26cellular response to fibroblast growth factor stimulusGO:00443449.4CYP11A1, STAR
27C21-steroid hormone biosynthetic processGO:00067009.4CYP11A1, CYP21A2, STAR
28response to antibioticGO:00466779.3CYP11A1, CYP21A2, STAR
29xenobiotic metabolic processGO:00068059.1CYP11A1, CYP17A1, CYP19A1, CYP21A2
30steroid biosynthetic processGO:00066949.1CYP11A1, CYP17A1, CYP19A1, STAR
31sterol metabolic processGO:00161259.1CYP11A1, CYP17A1, CYP19A1, CYP21A2
32response to estrogenGO:00436279.0CYP11A1, ESR1, STAR
33steroid metabolic processGO:00082028.5CYP11A1, CYP17A1, CYP19A1, CYP21A2, STAR
34oxidation-reduction processGO:00551148.4CYP11A1, CYP17A1, CYP19A1, CYP21A2
35response to organic substanceGO:00100338.4AFP, CYP11A1, STAR
36male gonad developmentGO:00085848.1CYP11A1, ESR1, INHA, LHCGR, STAR

Molecular functions related to Leydig Cell Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1steroid bindingGO:00054969.9CYP21A2, ESR1
2oxygen bindingGO:00198259.9CYP17A1, CYP19A1
3cholesterol bindingGO:00154859.9CYP11A1, STAR
4iron ion bindingGO:00055068.9CYP11A1, CYP17A1, CYP19A1, CYP21A2
5oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygenGO:00167058.8CYP11A1, CYP17A1, CYP19A1, CYP21A2
6heme bindingGO:00200378.7CYP11A1, CYP17A1, CYP19A1, CYP21A2

Sources for Leydig Cell Tumor

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet