MCID: LYD001
MIFTS: 44

Leydig Cell Tumor malady

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Leydig Cell Tumor

Aliases & Descriptions for Leydig Cell Tumor:

Name: Leydig Cell Tumor 12 52 42 14 69
Leydig Cell Tumor, Benign 69
Leydig Cell Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2696
MeSH 42 D007984
NCIt 47 C3188
SNOMED-CT 64 189739005 45002009
UMLS 69 C0023601

Summaries for Leydig Cell Tumor

MalaCards based summary : Leydig Cell Tumor, also known as leydig cell tumor, benign, is related to sertoli-leydig cell tumor and goiter, multinodular 1, with or without sertoli-leydig cell tumors. An important gene associated with Leydig Cell Tumor is LHCGR (Luteinizing Hormone/Choriogonadotropin Receptor), and among its related pathways/superpathways are Glucose / Energy Metabolism and Prolactin Signaling Pathway. The drugs Metformin and Simvastatin have been mentioned in the context of this disorder. Affiliated tissues include testis, ovary and lung, and related phenotypes are behavior/neurological and cellular

Related Diseases for Leydig Cell Tumor

Diseases in the Leydig Cell Tumor family:

Malignant Leydig Cell Tumor

Diseases related to Leydig Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 126)
id Related Disease Score Top Affiliating Genes
1 sertoli-leydig cell tumor 12.5
2 goiter, multinodular 1, with or without sertoli-leydig cell tumors 12.3
3 malignant leydig cell tumor 12.2
4 testicular leydig cell tumor 12.2
5 malignant sertoli-leydig cell tumor of ovary 12.1
6 malignant testicular leydig cell tumor 12.0
7 malignant sertoli-leydig cell tumor 11.9
8 periodic fever, aphthous stomatitis, pharyngitis and adenitis 10.3 CYP17A1 LHCGR
9 lymph node disease 10.2 AFP ESR1
10 nipple neoplasm 10.2 AFP INSL3
11 dyt1 early-onset isolated dystonia 10.2 CYP17A1 CYP21A2
12 arthus reaction 10.2 AFP ESR1
13 malignant granular cell myoblastoma 10.2 AFP PTHLH
14 primary effusion lymphoma 10.2 CYP21A2 LHCGR
15 sclerosing hemangioma 10.2 AFP ESR1
16 pigmented villonodular synovitis 10.2 AFP PTHLH
17 gynecomastia 10.2
18 biliary tract neoplasm 10.2 AFP ESR1
19 lung sarcoma 10.1 AFP PTHLH
20 distal monosomy 14q 10.1 CYP11A1 CYP21A2
21 congenital adrenal hyperplasia 10.1
22 tactile epilepsy 10.1 AFP PTHLH
23 malignant otitis externa 10.1 CYP11A1 CYP21A2
24 thai symphalangism syndrome 10.1 CYP19A1 LHCGR
25 pneumonia 10.1 AFP PTHLH
26 diabetes mellitus, insulin-resistant, with acanthosis nigricans 10.1 AFP ESR1 INSL3
27 leydig cell hypoplasia with pseudohermaphroditism 10.1 CYP19A1 LHCGR
28 androgen insensitivity 10.1
29 hyperandrogenism 10.1
30 cowden syndrome 1 10.0 CYP11A1 STAR
31 her2-receptor negative breast cancer 10.0 CYP19A1 ESR1
32 osteogenesis imperfecta 10.0 CYP19A1 ESR1
33 deafness, autosomal recessive 29 10.0 CYP11A1 CYP17A1 CYP21A2
34 celiac disease 12 10.0 CYP19A1 ESR1
35 tick-borne encephalitis 10.0 CYP11A1 CYP17A1 CYP21A2
36 perinatal jaundice due to hepatocellular damage 10.0 CYP19A1 ESR1
37 ameloblastoma 10.0 CYP11A1 CYP17A1 CYP21A2
38 panuveitis 10.0 CYP11A1 CYP17A1 CYP21A2
39 childhood optic tract astrocytoma 10.0 CYP11A1 CYP17A1 CYP21A2
40 adams-oliver syndrome 6 10.0 CYP19A1 ESR1
41 candidal paronychia 10.0 CYP11A1 STAR
42 complete androgen insensitivity syndrome 10.0
43 precocious puberty 10.0
44 rhinitis 10.0 ESR1 PTHLH
45 larynx leiomyoma 10.0 CYP19A1 ESR1
46 leukoencephalopathy with ataxia 10.0 CYP19A1 CYP21A2
47 esophagus sarcoma 10.0 CYP19A1 ESR1
48 x-linked sideroblastic anemia with ataxia 10.0 CYP11A1 CYP17A1 STAR
49 third ventricle chordoid glioma 10.0 CYP17A1 CYP19A1 LHCGR
50 cryptorchidism 10.0

Graphical network of the top 20 diseases related to Leydig Cell Tumor:



Diseases related to Leydig Cell Tumor

Symptoms & Phenotypes for Leydig Cell Tumor

MGI Mouse Phenotypes related to Leydig Cell Tumor:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.97 AFP CYP11A1 CYP17A1 CYP19A1 ESR1 INSL3
2 cellular MP:0005384 9.87 CYP17A1 CYP19A1 ESR1 INSL3 LHCGR PTHLH
3 endocrine/exocrine gland MP:0005379 9.86 ESR1 INSL3 LHCGR PTHLH STAR AFP
4 homeostasis/metabolism MP:0005376 9.76 AFP CYP11A1 CYP17A1 CYP19A1 ESR1 LHCGR
5 reproductive system MP:0005389 9.61 AFP CYP11A1 CYP17A1 CYP19A1 ESR1 INSL3
6 skeleton MP:0005390 9.1 CYP17A1 CYP19A1 ESR1 INSL3 LHCGR PTHLH

Drugs & Therapeutics for Leydig Cell Tumor

Drugs for Leydig Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 64)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4 657-24-9 14219 4091
2
Simvastatin Approved Phase 4 79902-63-9 54454
3
Resveratrol Experimental, Investigational Phase 4 501-36-0, 955365-80-7 24856436 445154
4 Anticholesteremic Agents Phase 4
5 Antimetabolites Phase 4,Phase 1
6 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
7 Hypoglycemic Agents Phase 4
8 Hypolipidemic Agents Phase 4
9 Lipid Regulating Agents Phase 4
10 Antineoplastic Agents, Phytogenic Phase 4,Phase 2
11 Analgesics Phase 4
12 Analgesics, Non-Narcotic Phase 4
13 Anti-Inflammatory Agents Phase 4
14 Anti-Inflammatory Agents, Non-Steroidal Phase 4
15 Antioxidants Phase 4
16 Antirheumatic Agents Phase 4
17 Peripheral Nervous System Agents Phase 4,Phase 2
18 Platelet Aggregation Inhibitors Phase 4
19 Protective Agents Phase 4
20
Methyltestosterone Approved Phase 2, Phase 3 58-18-4 6010
21
Testosterone Approved, Investigational Phase 2, Phase 3 58-22-0 6013
22 Anabolic Agents Phase 2, Phase 3
23 Androgens Phase 2, Phase 3
24 Antineoplastic Agents, Hormonal Phase 2, Phase 3
25 Castor Oil Phase 2, Phase 3
26 Cathartics Phase 2, Phase 3
27 Gastrointestinal Agents Phase 2, Phase 3
28 Hormone Antagonists Phase 2, Phase 3
29 Hormones Phase 2, Phase 3
30 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
31 Laxatives Phase 2, Phase 3
32 Testosterone 17 beta-cypionate Phase 2, Phase 3
33
Testosterone enanthate Phase 2, Phase 3 315-37-7 9416
34 Testosterone undecanoate Phase 2, Phase 3
35 Castor Nutraceutical Phase 2, Phase 3
36
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
37
Carboplatin Approved Phase 2,Phase 1 41575-94-4 10339178 498142 38904
38
Bleomycin Approved Phase 2 11056-06-7 5360373
39
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
40
Etoposide Approved Phase 2 33419-42-0 36462
41
Succinylcholine Approved Phase 2 306-40-1 5314
42
Bevacizumab Approved, Investigational Phase 2 216974-75-3
43 Albumin-Bound Paclitaxel Phase 2
44 Antimitotic Agents Phase 2
45 Anti-Bacterial Agents Phase 2
46 Antibiotics, Antitubercular Phase 2
47 Etoposide phosphate Phase 2
48 Neuromuscular Agents Phase 2
49 Neuromuscular Blocking Agents Phase 2
50 Neuromuscular Depolarizing Agents Phase 2

Interventional clinical trials:

(show all 13)
id Name Status NCT ID Phase
1 Effects of Metformin Plus Simvastatin on Polycystic Ovarian Syndrome (PCOS): A Prospective, Randomized, Double-Blind, Placebo-Controlled Study Completed NCT01021579 Phase 4
2 Effects of Simvastatin and Micronized Trans-resveratrol Treatment on Polycystic Ovary Syndrome (PCOS) Patients Recruiting NCT02766803 Phase 4
3 Androgen for Leydig Cell Proliferation Completed NCT01206270 Phase 2, Phase 3
4 Study of Testosterone vs Placebo in Testicular Cancer Survivors Recruiting NCT02991209 Phase 2, Phase 3
5 Paclitaxel in Treating Patients With Ovarian Stromal Cancer Completed NCT00006227 Phase 2
6 Paclitaxel and Carboplatin or Bleomycin Sulfate, Etoposide Phosphate, and Cisplatin in Treating Patients With Advanced or Recurrent Sex Cord-Ovarian Stromal Tumors Recruiting NCT01042522 Phase 2
7 Bevacizumab in Treating Patients With Recurrent Sex Cord-Stromal Tumors of the Ovary Active, not recruiting NCT00748657 Phase 2
8 Carboplatin, Gemcitabine Hydrochloride, and Stereotactic Body Radiation Therapy in Gynecological Cancer Completed NCT01652794 Phase 1
9 Studying Genes in Samples From Younger Patients With Ovarian or Testicular Sex Cord Stromal Tumors Completed NCT01572467
10 Stress Reduction in Improving Quality of Life in Patients With Recurrent Gynecologic or Breast Cancer Completed NCT01764789
11 DICER1-related Pleuropulmonary Blastoma Cancer Predisposition Syndrome: A Natural History Study Recruiting NCT01247597
12 Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome Recruiting NCT00565903
13 International Ovarian & Testicular Stromal Tumor Registry Recruiting NCT01970696

Search NIH Clinical Center for Leydig Cell Tumor

Cochrane evidence based reviews: leydig cell tumor

Genetic Tests for Leydig Cell Tumor

Anatomical Context for Leydig Cell Tumor

MalaCards organs/tissues related to Leydig Cell Tumor:

39
Testis, Ovary, Lung, Testes, Breast, Endothelial, Pituitary

Publications for Leydig Cell Tumor

Articles related to Leydig Cell Tumor:

(show top 50) (show all 371)
id Title Authors Year
1
An inguinal hernia with cryptorchidism with a Leydig cell tumor in an elderly man: A case report. ( 28171846 )
2017
2
Ovarian Sertoli-Leydig cell tumor with heterologous elements containing an unusual type of alpha-fetoprotein-producing cells. ( 27126717 )
2016
3
Leydig cell tumor of the testis with azoospermia and elevated delta4 androstenedione: case report. ( 27833751 )
2016
4
A Rare Case of Intra-Endometrial Leiomyoma of Uterus Simulating Degenerated Submucosal Leiomyoma Accompanied by a Large Sertoli-Leydig Cell Tumor. ( 26847310 )
2016
5
Recurrent ovarian Sertoli-Leydig cell tumor in a child with Peutz-Jeghers syndrome. ( 28101370 )
2016
6
The co-occurrence of an ovarian Sertoli-Leydig cell tumor with a thyroid carcinoma is highly suggestive of a DICER1 syndrome. ( 26983701 )
2016
7
Sertoli-Leydig cell tumor of the ovary: A diagnostic dilemma. ( 26937481 )
2016
8
Leydig cell tumor found incidentally during microscopic testicular sperm extraction in patient with mosaic Klinefelter syndrome: case report. ( 27523297 )
2016
9
Fertility-sparing management and obstetric outcomes in a 20-year-old patient with a Sertoli-Leydig cell tumor of the ovary: A case report and review of the literature. ( 27446397 )
2016
10
Recurrent Sertoli-Leydig cell tumor of ovary in 8-year-old girl. ( 27334531 )
2016
11
Large moderately-differentiated ovarian Sertoli-Leydig cell tumor in a 13-year-old female: A case report. ( 26893701 )
2016
12
Sertoli - Leydig cell tumor with retiform areas and overgrowth of rhabdomyosarcomatous elements: case report and literature review. ( 27473538 )
2016
13
Atypical Leydig Cell Tumor in Children: Report of 2 Cases. ( 27940757 )
2016
14
Leydig cell tumor in a patient with 49,XXXXY karyotype: a review of literature. ( 26160035 )
2015
15
Metastasized Leydig cell tumor in a dog. ( 26753337 )
2015
16
Alopecia and Hirsutism in a Postmenopausal Woman as the Presenting Complaint of Ovarian Hilus (Leydig) Cell Tumor. ( 25910403 )
2015
17
Testicular Leydig Cell Tumor with Metachronous Lesions: Outcomes after Metastasis Resection and Cryoablation. ( 26525589 )
2015
18
True Precocious Puberty Following Treatment of a Leydig Cell Tumor: Two Case Reports and Literature Review. ( 26579503 )
2015
19
Leydig cell tumor with lung metastasis diagnosed by lung biopsy. ( 26722493 )
2015
20
The oncogenic roles of DICER1 RNase IIIb domain mutations in ovarian Sertoli-Leydig cell tumors. ( 26408257 )
2015
21
Ovarian Sertoli-Leydig Cell Tumor with Predominant Heterologous Mucinous Differentiation and Foci of Hepatocytic Differentiation: Case Report and Review of The Literature. ( 26116602 )
2015
22
Leydig cell tumor incidentally detected by fused FDG-PET/MRI. ( 25636443 )
2015
23
Leydig cell tumor of testis with indeterminate features. ( 26960466 )
2015
24
Cervical embryonal rhabdomyosarcoma and ovarian Sertoli-Leydig cell tumor with congenital absence of unilateral ovary. ( 26458643 )
2015
25
Ovarian Sertoli-Leydig cell tumor with heterologous elements of gastrointestinal type associated with elevated serum alpha-fetoprotein level: an unusual case and literature review. ( 25926909 )
2014
26
Bilateral laparoscopic gonadectomy in a patient with complete androgen insensitivity syndrome and bilateral sertoli-leydig cell tumor: a case report and brief review of the literature. ( 25032133 )
2014
27
Sertoli-leydig cell tumor of ovary- a diagnostic dilemma. ( 24783104 )
2014
28
Ovarian Leydig cell tumor in a post-menopausal patient with severe hyperandrogenism. ( 24728167 )
2014
29
A novel DICER1 mutation identified in a female with ovarian Sertoli-Leydig cell tumor and multinodular goiter: a case report. ( 24708902 )
2014
30
Sertoli-Leydig cell tumors: hormonal profile after dynamic test with GnRH analogue: triptorelin represents a useful tool to evaluate tumoral hyperandrogenism. ( 25299229 )
2014
31
Bilateral sertoli-leydig cell tumor in a primigravida: a rare case. ( 25002956 )
2014
32
Woman with virilizing congenital adrenal hyperplasia and Leydig cell tumor of the ovary. ( 24702195 )
2014
33
A leydig cell tumor of the ovary resulting in extreme hyperandrogenism, erythrocytosis, and recurrent pulmonary embolism. ( 24152686 )
2014
34
Sertoli-Leydig cell tumor with heterologous element: a case report and a review of the literature. ( 24696734 )
2014
35
Metastatic relapse after initial clinical stage I testicular Leydig cell tumor. ( 24855728 )
2014
36
Testicular adrenal rest tumor mimicking leydig cell tumor in a patient with congenital adrenal hyperplasia. ( 24834391 )
2014
37
Sertoli-Leydig cell tumor with unique nail findings in a post-menopausal woman: a case report and literature review. ( 25296983 )
2014
38
Sertoli-Leydig cell tumor in a 12-year-old girl: a review article and case report. ( 25027813 )
2014
39
Sertoli-Leydig cell tumor of the ovary: analysis of a single institution database. ( 22691037 )
2013
40
Incidental detection of leydig cell tumor via fluorine-18-choline PET/CT in a patient with recurrent prostate cancer disease. ( 23856823 )
2013
41
Testicular adrenal rest "tumor" or Leydig cell tumor? A report of a challenging case with literature review. ( 23984262 )
2013
42
Virilization due to androgen hypersecretion in a patient with ovarian leydig cell tumor: diagnostic and psychosocial implications. ( 23770793 )
2013
43
Poorly differentiated ovarian sertoli-leydig cell tumor in a 16-year-old single woman: a case report and literature review. ( 23878752 )
2013
44
Ovarian Sertoli-Leydig cell tumor: a report of seven cases and a review of the literature. ( 23173550 )
2013
45
Long-term follow-up using testicle-sparing surgery for Leydig cell tumor. ( 23317518 )
2013
46
Leydig cell tumor in an anabolic steroid abuser. ( 23686162 )
2013
47
Fine needle aspiration cytology of Sertoli-Leydig cell tumors of ovary masquerading as dysgerminoma. ( 22102529 )
2013
48
Atypical leydig cell tumor in a young child. ( 24040603 )
2013
49
Complete Androgen Insensitivity Syndrome with a Sertoli-Leydig Cell Tumor. ( 24333107 )
2013
50
A case of successful salvage chemotherapy of recurrent ovarian sertoli-leydig cell tumor. ( 24328002 )
2013

Variations for Leydig Cell Tumor

Expression for Leydig Cell Tumor

Search GEO for disease gene expression data for Leydig Cell Tumor.

Pathways for Leydig Cell Tumor

Pathways related to Leydig Cell Tumor according to GeneCards Suite gene sharing:

(show all 12)
id Super pathways Score Top Affiliating Genes
1 12.14 CYP11A1 CYP19A1 STAR
2
Show member pathways
12.1 CYP17A1 ESR1 LHCGR
3
Show member pathways
12.03 CYP11A1 CYP21A2 STAR
4 11.71 INSL3 LHCGR PTHLH
5 11.47 CYP11A1 CYP21A2 STAR
6
Show member pathways
11.3 CYP11A1 CYP17A1 CYP19A1 CYP21A2 STAR
7
Show member pathways
11.26 CYP11A1 CYP17A1 CYP19A1 CYP21A2
8
Show member pathways
11.24 CYP17A1 CYP19A1
9 10.94 CYP19A1 LHCGR
10
Show member pathways
10.73 CYP17A1 CYP21A2
11 10.72 CYP11A1 CYP17A1 CYP19A1 LHCGR STAR
12 9.86 CYP19A1 ESR1

GO Terms for Leydig Cell Tumor

Biological processes related to Leydig Cell Tumor according to GeneCards Suite gene sharing:

(show all 15)
id Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.85 CYP11A1 CYP17A1 CYP19A1 CYP21A2
2 steroid metabolic process GO:0008202 9.67 CYP11A1 CYP17A1 CYP21A2
3 male gonad development GO:0008584 9.61 ESR1 LHCGR STAR
4 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.54 LHCGR PTHLH
5 androgen metabolic process GO:0008209 9.52 CYP19A1 ESR1
6 uterus development GO:0060065 9.51 CYP19A1 ESR1
7 C21-steroid hormone biosynthetic process GO:0006700 9.48 CYP11A1 STAR
8 estrogen biosynthetic process GO:0006703 9.46 CYP19A1 STAR
9 progesterone metabolic process GO:0042448 9.4 AFP CYP17A1
10 glucocorticoid biosynthetic process GO:0006704 9.37 CYP17A1 CYP21A2
11 cellular response to gonadotropin stimulus GO:0071371 9.32 LHCGR STAR
12 testosterone biosynthetic process GO:0061370 9.26 CYP19A1 STAR
13 sterol metabolic process GO:0016125 9.26 CYP11A1 CYP17A1 CYP19A1 CYP21A2
14 cellular response to luteinizing hormone stimulus GO:0071373 9.16 LHCGR STAR
15 steroid biosynthetic process GO:0006694 9.02 CYP11A1 CYP17A1 CYP19A1 CYP21A2 STAR

Molecular functions related to Leydig Cell Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.67 CYP11A1 CYP17A1 CYP19A1 CYP21A2
2 lipid binding GO:0008289 9.61 CYP21A2 ESR1 STAR
3 iron ion binding GO:0005506 9.46 CYP11A1 CYP17A1 CYP19A1 CYP21A2
4 oxygen binding GO:0019825 9.4 CYP17A1 CYP19A1
5 steroid binding GO:0005496 9.32 CYP21A2 ESR1
6 steroid hydroxylase activity GO:0008395 9.26 CYP19A1 CYP21A2
7 heme binding GO:0020037 9.26 CYP11A1 CYP17A1 CYP19A1 CYP21A2
8 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 8.92 CYP11A1 CYP17A1 CYP19A1 CYP21A2

Sources for Leydig Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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