MCID: LYD001
MIFTS: 50

Leydig Cell Tumor malady

Cancer diseases category

Summaries for Leydig Cell Tumor

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66Wikipedia, 34MalaCards
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Wikipedia:66 Leydig cell tumour, also Leydig cell tumor (US spelling), (testicular) interstitial cell tumour and... more...

MalaCards: Leydig Cell Tumor, also known as leydig cell neoplasm, is related to sertoli-leydig cell tumor and gynecomastia. An important gene associated with Leydig Cell Tumor is DICER1 (dicer 1, ribonuclease type III), and among its related pathways are Estrone metabolism and Ovarian steroidogenesis. The compounds pf 4981517 and methoxyresorufin have been mentioned in the context of this disorder. Affiliated tissues include testis, ovary and breast, and related mouse phenotypes are skeleton and normal.

Aliases & Classifications for Leydig Cell Tumor

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9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 36MeSH, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

leydig cell tumor 9 11 46 63
leydig cell neoplasm 9


External Ids:

Disease Ontology9 DOID:2696
MeSH36 D007984
SNOMED-CT59 189739005, 45002009
NCIt41 C3188

Related Diseases for Leydig Cell Tumor

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18GeneCards, 19GeneDecks
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Diseases in the Leydig Cell Tumor family:

Malignant Leydig Cell Tumor

Diseases related to Leydig Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 94)
idRelated DiseaseScoreTop Affiliating Genes
1sertoli-leydig cell tumor31.9AFP, INHA
2gynecomastia31.0INHA, CYP19A1, CYP17A1
3precocious puberty30.7CYP21A2, CYP19A1
4congenital adrenal hyperplasia30.7CYP17A1, CYP19A1, CYP21A2, NR5A1
5hyperandrogenism30.6CYP17A1, CYP19A1, CYP21A2, INSL3
6goiter30.6INSL3
7cryptorchidism30.6CYP19A1, INSL3, NR5A1
8adrenal rest tumor30.4CYP21A2, NR5A1
9sertoli cell tumor30.3INHA, CYP19A1
10pseudohermaphroditism30.3CYP17A1, CYP19A1
11adenoma30.3CYP17A1, CYP21A2, INHA, NR5A1
1221-hydroxylase deficiency30.3CYP21A2, INHA
13dysgerminoma30.3INHA, AFP
14adenocarcinoma30.3CYP21A2, INHA, AFP, NR5A1
15adrenal adenoma30.2CYP17A1, CYP19A1, CYP21A2
16endometrial carcinoma30.2INHA, CYP19A1, CYP17A1
17choriocarcinoma30.1CYP19A1, INHA, AFP, NR5A1
18klinefelter's syndrome30.1CYP19A1, CYP21A2, INHA, NR5A1
19infertility30.0CYP19A1, CYP21A2, INSL3, INHA, NR5A1
20breast cancer30.0CYP17A1, CYP19A1, CYP21A2, INHA, NR5A1
21testicular leydig cell tumor10.8
22malignant leydig cell tumor10.8
23hypercalcemia10.6
24androgen insensitivity syndrome10.5
25sarcoma10.4
26complete androgen insensitivity syndrome10.4
27malignant testicular leydig cell tumor10.4
28cystadenoma10.4
29humoral hypercalcemia of malignancy10.4
30goiter, multinodular 1, with or without sertoli-leydig cell tumors10.4
31teratoma10.4
32ovarian malignant sertoli-leydig cell tumor10.4
33multinodular goiter10.3
34malignant sertoli-leydig cell tumor10.3
35amenorrhea10.3
36cervicitis10.3
37mature teratoma10.3
38rhabdomyosarcoma10.3
39mucinous adenocarcinoma10.1
40unilateral retinoblastoma10.1
41renal agenesis10.1
42tuberous sclerosis10.1
43rete testis adenocarcinoma10.1
44breast adenoma10.1
45cystic teratoma10.1
46impotence10.1
47islet cell tumor10.1
48mediastinitis10.1
49primitive neuroectodermal tumor10.1
50prostate cancer10.1

Graphical network of the top 20 diseases related to Leydig Cell Tumor:



Diseases related to leydig cell tumor

Symptoms for Leydig Cell Tumor

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Drugs & Therapeutics for Leydig Cell Tumor

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Leydig Cell Tumor

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Anatomical Context for Leydig Cell Tumor

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34MalaCards
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MalaCards organs/tissues related to Leydig Cell Tumor:

34
Testis, Ovary, Breast, Endothelial, Testes, Prostate, Bone, Lung, Liver, Skeletal muscle, Pituitary

Animal Models for Leydig Cell Tumor or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Leydig Cell Tumor:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.6CYP19A1, INSL3, INHA, DICER1
2MP:00028738.5NR5A1, DICER1, INHA, CYP19A1
3MP:00053797.6CYP19A1, INSL3, INHA, AFP, DICER1, NR5A1
4MP:00053867.5CYP17A1, CYP19A1, INSL3, AFP, DICER1, NR5A1
5MP:00053767.3CYP17A1, CYP19A1, INHA, AFP, DICER1, NR5A1
6MP:00053897.1NR5A1, CYP17A1, CYP19A1, INSL3, INHA, AFP

Publications for Leydig Cell Tumor

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53PubMed
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Articles related to Leydig Cell Tumor:

(show top 50)    (show all 329)
idTitleAuthorsYear
1
A case of successful salvage chemotherapy of recurrent ovarian sertoli-leydig cell tumor. (24328002)
2013
2
"Occult" ovarian Leydig cell tumor: when laboratory tells more than imaging. (24091542)
2013
3
Cervical sarcoma botryoides and ovarian Sertoli-Leydig cell tumor: a case report and review of literature. (21847587)
2012
4
Leydig cell tumor in two brothers with congenital adrenal hyperplasia due to 11-I^ hydroxylase deficiency: a case report. (21259051)
2012
5
Malignant ovarian Sertoli-Leydig cell tumor localized with selective ovarian vein sampling. (23084689)
2012
6
Sertoli-Leydig cell tumor of the ovary--morphological and immunohistochemical analysis. (22635079)
2012
7
Leydig cell tumor: a report of two cases with unusual presentation. (21045421)
2010
8
Leydig cell tumor of the testis. (19303105)
2009
9
Hyperandrogenism due to a testosterone-secreting Sertoli-Leydig cell tumor associated with a dehydroepiandrosterone sulfate-secreting adrenal adenoma in a postmenopausal woman: case presentation and review of literature. (19289327)
2009
10
Virilizing ovarian Leydig cell tumor in a woman with subclinical Cushing syndrome. (18463044)
2008
11
Histologic and immunohistochemical characterization of a testicular mixed germ cell sex cord-stromal tumor and a leydig cell tumor in a dog. (18039910)
2007
12
Estrogen receptor alpha and progesterone receptor expression in ovarian adult granulosa cell tumors and Sertoli-Leydig cell tumors. (17885486)
2007
13
A rare ovarian tumor - Sertoli-Leydig cell tumor with heterologous element. (18311394)
2007
14
Sertoli-Leydig cell tumor of ovary with heterologous element: a case report. (16366107)
2005
15
Large cell calcifying Sertoli cell tumor of the testis: comparative immunohistochemical study with Leydig cell tumor. (15943795)
2005
16
Human endocrine gland-derived vascular endothelial growth factor: expression early in development and in Leydig cell tumors suggests roles in normal and pathological testis angiogenesis. (15292351)
2004
17
Sertoli-Leydig cell tumor of the ovary. (15216408)
2004
18
Pathologic quiz case: patient with testicular pain. Benign Leydig cell tumor. (14692826)
2004
19
A constitutively active somatic mutation of the human lutropin receptor found in Leydig cell tumors activates the same families of G proteins as germ line mutations associated with Leydig cell hyperplasia. (12933660)
2003
20
Absence of activating mutations in the hot spots of the LH receptor and Gs-alpha genes in Leydig cell tumors. (12150333)
2002
21
Occult Leydig cell tumor in a patient with gynecomastia. (11497478)
2001
22
Elevated levels of inhibin-A and immunoreactive inhibin in aged male Wistar rats with testicular Leydig cell tumor. (11545298)
2001
23
Leydig-cell tumors caused by an activating mutation of the gene encoding the luteinizing hormone receptor. (10580072)
1999
24
Bilateral ovarian stromal hyperplasia concealing a nonhilar, pure stromal-Leydig cell tumor. A case report. (10394554)
1999
25
Leydig cell tumor of the testis: a clinicopathologic, DNA content, and MIB-1 comparison of nonmetastasizing and metastasizing tumors. (9808128)
1998
26
Activating mutation of the stimulatory G protein (gsp) as a putative cause of ovarian and testicular human stromal Leydig cell tumors. (9626141)
1998
27
Presence of 17 beta-hydroxysteroid dehydrogenase type 3 messenger ribonucleic acid transcript in an ovarian Sertoli-Leydig cell tumor. (9314929)
1997
28
Virilizing stromal Leydig cell tumor (Leydig cell-containing thecoma) of the ovary in pregnancy. A case report with extensive immunohistochemical investigation of the tumor cells. (8542508)
1995
29
Precocious puberty in a child with unilateral Leydig cell tumor of the testis following orchiopexy. (8105109)
1993
30
Regulation of parathyroid hormone-related peptide production in vitro by the rat hypercalcemic Leydig cell tumor H-500. (8462465)
1993
31
Ultrastructure and immunohistochemistry of a fetal-type Leydig cell tumor. (1448884)
1992
32
Isosexual male precocity due to a Leydig cell tumor. (1291502)
1992
33
Treatment of malignant Leydig cell tumor. (1913469)
1991
34
Diagnosis and resection of an oral contraceptive-suppressible Sertoli-Leydig cell tumor with preservation of fertility and a 7-year follow-up. (2523030)
1989
35
Sertoli-Leydig cell tumor associated with a mature cystic teratoma in a single ovary. (2587573)
1989
36
Ovarian Sertoli-Leydig cell tumor with elevated serum alpha-fetoprotein. (2467733)
1989
37
Steroidogenesis-activator polypeptide isolated from a rat Leydig cell tumor. (3563495)
1987
38
In vitro secretion of deoxycorticosterone by a benign Leydig cell tumor of the testis. (3712595)
1986
39
The rat LTW(m) Leydig cell tumor: cancer anorexia due to estrogen. (6587964)
1984
40
A transplantable rat Leydig cell tumor: binding properties, hormonal responsiveness, and tumor growth. (6100028)
1984
41
Leydig cell tumor in patient on estrogen therapy. (6857903)
1983
42
A Sertoli-Leydig cell tumor and pregnancy. Clinical, endocrine, radiologic, and electron microscopic findings. (6660923)
1983
43
Metastatic Sertoli-Leydig cell tumor of the ovary during pregnancy treated by BV-CAP chemotherapy. (6177244)
1982
44
Ultrastructure of a virilizing ovarian Leydig-cell-tumor. Hilar cell tumor. (6293161)
1982
45
Lipid composition and gonadotropin-mediated lipid metabolism of the M5480 murine Leydig cell tumor. (7441057)
1980
46
Steroidogenesis in HCG-responsive Leydig cell tumor variants. (314019)
1979
47
Leydig-cell tumor of the testis with gynecomastia and elevated estrogen levels. (868795)
1977
48
Estrogen-induced Leydig cell tumor in the mouse: a model system for the study of carcinogenesis and hormone dependency. (11351)
1976
49
Sertoli-Leydig cell tumor of the ovary, with an associated mucinous cystadenoma. An ultrastructural and endocrine study. (4280005)
1974
50
Estrogenic Leydig-cell tumor with multiple metastases in a dog; the problem of bisexual hormone production by gonadal cells. (13367157)
1956

Variations for Leydig Cell Tumor

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Expression for genes affiliated with Leydig Cell Tumor

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Leydig Cell Tumor

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Pathways for genes affiliated with Leydig Cell Tumor

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51PathCards, 61Thomson Reuters, 31KEGG, 39NCBI BioSystems Database, 56Reactome, 52PharmGKB
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Pathways related to Leydig Cell Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Estrogen biosynthesis61
Androstenedione and testosterone biosynthesis and metabolism p.161
9.6CYP19A1, CYP17A1
29.6CYP19A1, CYP17A1
3
Show member pathways
estradiol biosynthesis II39
androgen biosynthesis39
estradiol biosynthesis I39
progesterone biosynthesis39
9.6CYP19A1, CYP17A1
4
Show member pathways
9.0CYP17A1, CYP19A1, CYP21A2
5
Show member pathways
9.0CYP17A1, CYP19A1, CYP21A2
6
Show member pathways
9.0CYP21A2, CYP19A1, CYP17A1
7
Show member pathways
Glucocorticoid andamp; Mineralcorticoid Metabolism39
9.0CYP21A2, CYP19A1, CYP17A1
88.8CYP19A1, INHA, NR5A1

Compounds for genes affiliated with Leydig Cell Tumor

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62Tocris Bioscience, 46Novoseek, 30IUPHAR, 12DrugBank, 25HMDB, 52PharmGKB
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Compounds related to Leydig Cell Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 76)
idCompoundScoreTop Affiliating Genes
1pf 4981517629.9CYP17A1, CYP19A1
2methoxyresorufin629.9CYP17A1, CYP19A1
3nafarelin46 62 30 1212.8CYP19A1, CYP21A2
4pregnanediol469.7CYP21A2, CYP17A1
511beta-Hydroxyprogesterone259.7CYP17A1, CYP21A2
611b-Hydroxyprogesterone259.7CYP17A1, CYP21A2
721-deoxycortisol46 2510.7CYP21A2, CYP17A1
817a-Hydroxypregnenolone259.7CYP21A2, CYP17A1
9Pregnenolone25 1210.7CYP21A2, CYP17A1
10atrazine469.6CYP19A1, NR5A1
11acth 1-24469.6CYP17A1, CYP21A2
12pentoxyresorufin46 6210.6CYP19A1, CYP17A1
1317-hydroxypregnenolone469.6CYP17A1, CYP21A2
14doca469.5CYP17A1, CYP21A2
1511 deoxycortisol469.5CYP17A1, CYP21A2
16aminoglutethimide46 1210.5CYP19A1, CYP21A2
17pcb 126469.4CYP21A2, CYP19A1, CYP17A1
18clomiphene citrate469.4AFP, CYP21A2, CYP19A1
1917-hydroxyprogesterone46 2510.4CYP17A1, CYP19A1, CYP21A2
20ketoconazole46 30 25 1212.4CYP21A2, CYP19A1, CYP17A1
21dihydrotestosterone46 30 25 1212.2CYP21A2, CYP19A1, CYP17A1
22NADP259.0CYP21A2, CYP19A1, CYP17A1
23carbon469.0AFP, CYP21A2, CYP17A1
24androstenedione46 259.9CYP17A1, CYP19A1, CYP21A2, INHA
25heme30 25 1210.9CYP21A2, CYP19A1, CYP17A1
26corticosterone46 62 2510.8NR5A1, CYP21A2, CYP17A1
27valine468.8AFP, INSL3, CYP21A2, CYP17A1
28hydrogen46 259.7CYP17A1, CYP21A2, INHA, AFP
29estrone46 30 25 1211.7CYP17A1, CYP19A1, AFP, NR5A1
30vitamin d468.6CYP17A1, CYP19A1, AFP, NR5A1
31dehydroepiandrosterone sulfate468.6CYP17A1, CYP19A1, CYP21A2, NR5A1
3217beta-hydroxysteroid468.6CYP17A1, CYP19A1, CYP21A2, NR5A1
33dhea468.6CYP17A1, CYP19A1, CYP21A2, NR5A1
34cyclic amp46 259.5CYP17A1, INSL3, INHA, NR5A1
35acth468.5CYP17A1, CYP21A2, INHA, NR5A1
36ribonucleic acid468.4CYP17A1, CYP21A2, INHA, NR5A1
37cycloheximide468.4NR5A1, CYP21A2, CYP19A1, CYP17A1
38forskolin46 52 1210.4CYP17A1, CYP21A2, INHA, NR5A1
39diethylstilbestrol46 30 1210.3CYP17A1, CYP19A1, INSL3, AFP, NR5A1
40dexamethasone46 52 30 1211.1CYP17A1, CYP19A1, CYP21A2, AFP
41gnrh468.1CYP17A1, CYP19A1, CYP21A2, INHA, NR5A1
42cholesterol46 30 25 1211.1CYP17A1, CYP21A2, AFP, NR5A1
43threonine468.0CYP17A1, CYP21A2, INSL3, AFP, NR5A1
44oligonucleotide467.9CYP17A1, CYP21A2, INHA, AFP, NR5A1
453beta-hydroxysteroid467.7NR5A1, INHA, INSL3, CYP21A2, CYP19A1, CYP17A1
46estradiol46 25 129.6CYP17A1, CYP19A1, CYP21A2, INHA, AFP, NR5A1
47progesterone46 30 62 25 1211.6CYP17A1, CYP19A1, CYP21A2, INHA, AFP, NR5A1
48testosterone46 62 25 1210.2CYP17A1, CYP19A1, CYP21A2, INSL3, INHA, AFP
49steroid467.2CYP17A1, CYP19A1, CYP21A2, INSL3, INHA, AFP
50estrogen467.2CYP17A1, CYP19A1, CYP21A2, INSL3, INHA, AFP

GO Terms for genes affiliated with Leydig Cell Tumor

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17Gene Ontology
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Biological processes related to Leydig Cell Tumor according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1regulation of cell cycleGO:0517269.7DICER1, INHA
2progesterone metabolic processGO:0424489.6AFP, CYP17A1
3steroid biosynthetic processGO:0066949.5CYP17A1, CYP19A1
4glucocorticoid biosynthetic processGO:0067049.4CYP17A1, CYP21A2
5sterol metabolic processGO:0161259.2CYP21A2, CYP19A1, CYP17A1
6steroid metabolic processGO:0082029.2CYP21A2, CYP19A1, CYP17A1
7adrenal gland developmentGO:0303259.1NR5A1, CYP17A1
8xenobiotic metabolic processGO:0068059.0CYP21A2, CYP19A1, CYP17A1
9male gonad developmentGO:0085849.0INSL3, INHA, NR5A1
10cell-cell signalingGO:0072678.5NR5A1, INHA, INSL3

Molecular functions related to Leydig Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.6INHA, INSL3
2oxygen bindingGO:0198259.3CYP19A1, CYP17A1
3heme bindingGO:0200379.0CYP21A2, CYP19A1, CYP17A1
4iron ion bindingGO:0055068.9CYP17A1, CYP19A1, CYP21A2

Products for genes affiliated with Leydig Cell Tumor

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  • Antibodies
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Sources for Leydig Cell Tumor

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet