MCID: LYD001
MIFTS: 48

Leydig Cell Tumor malady

Cancer diseases category

Summaries for Leydig Cell Tumor

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MalaCards based summary: Leydig Cell Tumor, also known as leydig cell neoplasm, is related to sertoli-leydig cell tumor and gynecomastia. An important gene associated with Leydig Cell Tumor is DICER1 (dicer 1, ribonuclease type III), and among its related pathways are superpathway of steroid hormone biosynthesis and Estrone metabolism. The compounds methoxyresorufin and pf 4981517 have been mentioned in the context of this disorder. Affiliated tissues include testis, ovary and breast, and related mouse phenotypes are skeleton and normal.

Aliases & Classifications for Leydig Cell Tumor

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Sources:
10Disease Ontology, 12DISEASES, 45Novoseek, 62UMLS, 57SNOMED-CT, 35MeSH, 40NCIt
See all sources

Leydig Cell Tumor, Aliases & Descriptions:

Name: Leydig Cell Tumor 10 12 45 62
 
Leydig Cell Neoplasm 10 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology10 DOID:2696
MeSH35 D007984
SNOMED-CT57 189739005, 45002009
NCIt40 C3188

Related Diseases for Leydig Cell Tumor

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Diseases in the Leydig Cell Tumor family:

Malignant Leydig Cell Tumor

Diseases related to Leydig Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 91)
idRelated DiseaseScoreTop Affiliating Genes
1sertoli-leydig cell tumor31.9AFP, INHA
2gynecomastia31.0INHA, CYP19A1, CYP17A1
3congenital adrenal hyperplasia30.8CYP17A1, CYP19A1, CYP21A2, NR5A1
4hyperandrogenism30.8CYP17A1, CYP19A1, CYP21A2, INSL3
5precocious puberty30.7CYP21A2, CYP19A1
6goiter30.7INSL3
7adrenal rest tumor30.6CYP21A2, NR5A1
8cryptorchidism30.6CYP19A1, INSL3, NR5A1
9adenoma30.4CYP17A1, CYP21A2, INHA, NR5A1
10adenocarcinoma30.4CYP21A2, INHA, AFP, NR5A1
11sertoli cell tumor30.3INHA, CYP19A1
12pseudohermaphroditism30.3CYP17A1, CYP19A1
13dysgerminoma30.3INHA, AFP
14adrenal adenoma30.2CYP17A1, CYP19A1, CYP21A2
15choriocarcinoma30.2CYP19A1, INHA, AFP, NR5A1
16klinefelter's syndrome30.2CYP19A1, CYP21A2, INHA, NR5A1
17infertility30.1CYP19A1, CYP21A2, INSL3, INHA, NR5A1
18breast cancer30.1CYP17A1, CYP19A1, CYP21A2, INHA, NR5A1
19testicular leydig cell tumor10.8
20malignant leydig cell tumor10.8
21hypercalcemia10.6
22androgen insensitivity10.6
23goiter, multinodular 1, with or without sertoli-leydig cell tumors10.5
24complete androgen insensitivity syndrome10.5
25sarcoma10.5
26malignant testicular leydig cell tumor10.4
27cystadenoma10.4
28multinodular goiter10.4
29teratoma10.4
30malignant sertoli-leydig cell tumor of ovary10.4
31amenorrhea10.3
32malignant sertoli-leydig cell tumor10.3
33cervicitis10.3
34mature teratoma10.3
35rhabdomyosarcoma10.3
36prostate cancer10.2
37retinoblastoma10.2
38hematopoietic stem cell transplantation10.2
39islet cell tumor10.2
40neuroectodermal tumor10.2
41mucinous adenocarcinoma10.2
42unilateral retinoblastoma10.2
43tuberous sclerosis10.2
44rete testis adenocarcinoma10.2
45breast adenoma10.2
46cystic teratoma10.2
47impotence10.2
48mediastinitis10.2
49prostatitis10.2
50pulmonary embolism10.2

Graphical network of the top 20 diseases related to Leydig Cell Tumor:



Diseases related to leydig cell tumor

Symptoms for Leydig Cell Tumor

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Drugs & Therapeutics for Leydig Cell Tumor

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Drug clinical trials:

Search ClinicalTrials for Leydig Cell Tumor

Search NIH Clinical Center for Leydig Cell Tumor

Genetic Tests for Leydig Cell Tumor

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Anatomical Context for Leydig Cell Tumor

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MalaCards organs/tissues related to Leydig Cell Tumor:

33
Testis, Ovary, Breast, Testes, Bone, Skeletal muscle, Liver, Lung, Prostate, Endothelial, Pituitary

Animal Models for Leydig Cell Tumor or affiliated genes

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MGI Mouse Phenotypes related to Leydig Cell Tumor:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.6CYP19A1, INSL3, INHA, DICER1
2MP:00028738.5NR5A1, DICER1, INHA, CYP19A1
3MP:00053797.6CYP19A1, INSL3, INHA, AFP, DICER1, NR5A1
4MP:00053867.5CYP17A1, CYP19A1, INSL3, AFP, DICER1, NR5A1
5MP:00053767.3CYP17A1, CYP19A1, INHA, AFP, DICER1, NR5A1
6MP:00053897.1NR5A1, CYP17A1, CYP19A1, INSL3, INHA, AFP

Publications for Leydig Cell Tumor

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Articles related to Leydig Cell Tumor:

(show top 50)    (show all 344)
idTitleAuthorsYear
1
Leydig cell tumor incidentally detected by fused FDG-PET/MRI. (25636443)
2015
2
Testicular adrenal rest tumor mimicking leydig cell tumor in a patient with congenital adrenal hyperplasia. (24834391)
2014
3
Bilateral sertoli-leydig cell tumor in a primigravida: a rare case. (25002956)
2014
4
Bilateral laparoscopic gonadectomy in a patient with complete androgen insensitivity syndrome and bilateral sertoli-leydig cell tumor: a case report and brief review of the literature. (25032133)
2014
5
A case of successful salvage chemotherapy of recurrent ovarian sertoli-leydig cell tumor. (24328002)
2013
6
"Occult" ovarian Leydig cell tumor: when laboratory tells more than imaging. (24091542)
2013
7
Cervical sarcoma botryoides and ovarian Sertoli-Leydig cell tumor: a case report and review of literature. (21847587)
2012
8
Leydig cell tumor in two brothers with congenital adrenal hyperplasia due to 11-I^ hydroxylase deficiency: a case report. (21259051)
2012
9
Malignant ovarian Sertoli-Leydig cell tumor localized with selective ovarian vein sampling. (23084689)
2012
10
Leydig cell tumor: a report of two cases with unusual presentation. (21045421)
2010
11
Leydig cell tumor of the testis. (19303105)
2009
12
Histologic and immunohistochemical characterization of a testicular mixed germ cell sex cord-stromal tumor and a leydig cell tumor in a dog. (18039910)
2007
13
Estrogen receptor alpha and progesterone receptor expression in ovarian adult granulosa cell tumors and Sertoli-Leydig cell tumors. (17885486)
2007
14
A rare ovarian tumor - Sertoli-Leydig cell tumor with heterologous element. (18311394)
2007
15
Sertoli-Leydig cell tumor of ovary with heterologous element: a case report. (16366107)
2005
16
Human endocrine gland-derived vascular endothelial growth factor: expression early in development and in Leydig cell tumors suggests roles in normal and pathological testis angiogenesis. (15292351)
2004
17
Sertoli-Leydig cell tumor of the ovary. (15216408)
2004
18
Pathologic quiz case: patient with testicular pain. Benign Leydig cell tumor. (14692826)
2004
19
A constitutively active somatic mutation of the human lutropin receptor found in Leydig cell tumors activates the same families of G proteins as germ line mutations associated with Leydig cell hyperplasia. (12933660)
2003
20
Absence of activating mutations in the hot spots of the LH receptor and Gs-alpha genes in Leydig cell tumors. (12150333)
2002
21
Male LH-independent sexual precocity in a 3.5-year-old boy caused by a somatic activating mutation of the LH receptor in a Leydig cell tumor. (11889161)
2002
22
Occult Leydig cell tumor in a patient with gynecomastia. (11497478)
2001
23
Elevated levels of inhibin-A and immunoreactive inhibin in aged male Wistar rats with testicular Leydig cell tumor. (11545298)
2001
24
Leydig-cell tumors caused by an activating mutation of the gene encoding the luteinizing hormone receptor. (10580072)
1999
25
Bilateral ovarian stromal hyperplasia concealing a nonhilar, pure stromal-Leydig cell tumor. A case report. (10394554)
1999
26
Leydig cell tumor of the testis: a clinicopathologic, DNA content, and MIB-1 comparison of nonmetastasizing and metastasizing tumors. (9808128)
1998
27
Activating mutation of the stimulatory G protein (gsp) as a putative cause of ovarian and testicular human stromal Leydig cell tumors. (9626141)
1998
28
Presence of 17 beta-hydroxysteroid dehydrogenase type 3 messenger ribonucleic acid transcript in an ovarian Sertoli-Leydig cell tumor. (9314929)
1997
29
Virilizing stromal Leydig cell tumor (Leydig cell-containing thecoma) of the ovary in pregnancy. A case report with extensive immunohistochemical investigation of the tumor cells. (8542508)
1995
30
Immunohistochemical and biochemical analysis of a human Sertoli-Leydig cell tumor: autonomous steroid production characteristic of ovarian theca cells. (9420846)
1995
31
Precocious puberty in a child with unilateral Leydig cell tumor of the testis following orchiopexy. (8105109)
1993
32
Ultrastructure and immunohistochemistry of a fetal-type Leydig cell tumor. (1448884)
1992
33
Isosexual male precocity due to a Leydig cell tumor. (1291502)
1992
34
Treatment of malignant Leydig cell tumor. (1913469)
1991
35
Diagnosis and resection of an oral contraceptive-suppressible Sertoli-Leydig cell tumor with preservation of fertility and a 7-year follow-up. (2523030)
1989
36
Sertoli-Leydig cell tumor associated with a mature cystic teratoma in a single ovary. (2587573)
1989
37
Ovarian Sertoli-Leydig cell tumor with elevated serum alpha-fetoprotein. (2467733)
1989
38
Steroidogenesis-activator polypeptide isolated from a rat Leydig cell tumor. (3563495)
1987
39
In vitro secretion of deoxycorticosterone by a benign Leydig cell tumor of the testis. (3712595)
1986
40
The rat LTW(m) Leydig cell tumor: cancer anorexia due to estrogen. (6587964)
1984
41
A transplantable rat Leydig cell tumor: binding properties, hormonal responsiveness, and tumor growth. (6100028)
1984
42
Leydig cell tumor in patient on estrogen therapy. (6857903)
1983
43
Metastatic Sertoli-Leydig cell tumor of the ovary during pregnancy treated by BV-CAP chemotherapy. (6177244)
1982
44
Ultrastructure of a virilizing ovarian Leydig-cell-tumor. Hilar cell tumor. (6293161)
1982
45
Lipid composition and gonadotropin-mediated lipid metabolism of the M5480 murine Leydig cell tumor. (7441057)
1980
46
Steroidogenesis in HCG-responsive Leydig cell tumor variants. (314019)
1979
47
Leydig-cell tumor of the testis with gynecomastia and elevated estrogen levels. (868795)
1977
48
Estrogen-induced Leydig cell tumor in the mouse: a model system for the study of carcinogenesis and hormone dependency. (11351)
1976
49
Sertoli-Leydig cell tumor of the ovary, with an associated mucinous cystadenoma. An ultrastructural and endocrine study. (4280005)
1974
50
Estrogenic Leydig-cell tumor with multiple metastases in a dog; the problem of bisexual hormone production by gonadal cells. (13367157)
1956

Variations for Leydig Cell Tumor

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Expression for genes affiliated with Leydig Cell Tumor

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Search GEO for disease gene expression data for Leydig Cell Tumor.

Pathways for genes affiliated with Leydig Cell Tumor

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Pathways related to Leydig Cell Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
estradiol biosynthesis II38
androgen biosynthesis38
estradiol biosynthesis I38
progesterone biosynthesis38
9.6CYP17A1, CYP19A1
2
Show member pathways
Estrogen biosynthesis60
Androstenedione and testosterone biosynthesis and metabolism p.160
9.6CYP17A1, CYP19A1
39.6CYP19A1, CYP17A1
4
Show member pathways
9.0CYP17A1, CYP19A1, CYP21A2
5
Show member pathways
9.0CYP17A1, CYP19A1, CYP21A2
6
Show member pathways
9.0CYP21A2, CYP17A1, CYP19A1
7
Show member pathways
Glucocorticoid andamp; Mineralcorticoid Metabolism38
9.0CYP19A1, CYP21A2, CYP17A1
88.8CYP19A1, NR5A1, INHA

Compounds for genes affiliated with Leydig Cell Tumor

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Compounds related to Leydig Cell Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 76)
idCompoundScoreTop Affiliating Genes
1methoxyresorufin619.9CYP19A1, CYP17A1
2pf 4981517619.9CYP19A1, CYP17A1
3nafarelin45 61 30 1312.8CYP21A2, CYP19A1
4pregnanediol459.7CYP17A1, CYP21A2
511b-Hydroxyprogesterone269.7CYP21A2, CYP17A1
611beta-Hydroxyprogesterone269.7CYP17A1, CYP21A2
717a-Hydroxypregnenolone269.7CYP17A1, CYP21A2
821-deoxycortisol45 2610.7CYP17A1, CYP21A2
9Pregnenolone26 1310.7CYP17A1, CYP21A2
10atrazine459.6NR5A1, CYP19A1
11acth 1-24459.6CYP21A2, CYP17A1
12pentoxyresorufin45 6110.6CYP19A1, CYP17A1
1317-hydroxypregnenolone459.6CYP21A2, CYP17A1
1411 deoxycortisol459.5CYP21A2, CYP17A1
15aminoglutethimide45 1310.5CYP19A1, CYP21A2
16doca459.5CYP21A2, CYP17A1
17pcb 126459.4CYP19A1, CYP21A2, CYP17A1
18clomiphene citrate459.4CYP19A1, CYP21A2, AFP
1917-hydroxyprogesterone45 2610.4CYP21A2, CYP19A1, CYP17A1
20ketoconazole45 30 26 1312.4CYP19A1, CYP21A2, CYP17A1
21dihydrotestosterone45 30 26 1312.2CYP21A2, CYP19A1, CYP17A1
22NADP269.0CYP19A1, CYP21A2, CYP17A1
23carbon459.0CYP17A1, AFP, CYP21A2
24androstenedione45 269.9INHA, CYP17A1, CYP21A2, CYP19A1
25heme30 26 1310.9CYP17A1, CYP21A2, CYP19A1
26corticosterone45 61 2610.8NR5A1, CYP17A1, CYP21A2
27valine458.8INSL3, CYP21A2, CYP17A1, AFP
28hydrogen45 269.7AFP, CYP21A2, CYP17A1, INHA
29estrone45 30 26 1311.7NR5A1, AFP, CYP19A1, CYP17A1
30vitamin d458.6CYP17A1, AFP, CYP19A1, NR5A1
3117beta-hydroxysteroid458.6NR5A1, CYP21A2, CYP17A1, CYP19A1
32dehydroepiandrosterone sulfate458.6CYP17A1, NR5A1, CYP21A2, CYP19A1
33dhea458.6CYP17A1, CYP19A1, CYP21A2, NR5A1
34cyclic amp45 269.5CYP17A1, INHA, INSL3, NR5A1
35acth458.5INHA, CYP21A2, NR5A1, CYP17A1
36ribonucleic acid458.4NR5A1, INHA, CYP17A1, CYP21A2
37cycloheximide458.4NR5A1, CYP21A2, CYP19A1, CYP17A1
38forskolin45 51 1310.4NR5A1, INHA, CYP17A1, CYP21A2
39diethylstilbestrol45 30 1310.3NR5A1, AFP, INSL3, CYP17A1, CYP19A1
40dexamethasone45 51 30 1311.1CYP19A1, CYP21A2, AFP, CYP17A1
41gnrh458.1CYP17A1, INHA, NR5A1, CYP19A1, CYP21A2
42cholesterol45 30 26 1311.1CYP17A1, AFP, NR5A1, CYP21A2
43threonine458.0NR5A1, CYP21A2, CYP17A1, AFP, INSL3
44oligonucleotide457.9INHA, AFP, NR5A1, CYP21A2, CYP17A1
453beta-hydroxysteroid457.7CYP19A1, INSL3, NR5A1, INHA, CYP21A2, CYP17A1
46estradiol45 26 139.6CYP19A1, AFP, INHA, CYP17A1, NR5A1, CYP21A2
47progesterone45 30 61 26 1311.6NR5A1, AFP, INHA, CYP21A2, CYP19A1, CYP17A1
48testosterone45 61 26 1310.2CYP17A1, CYP19A1, CYP21A2, INSL3, AFP, NR5A1
49steroid457.2NR5A1, INHA, INSL3, CYP21A2, CYP19A1, CYP17A1
50estrogen457.2NR5A1, CYP17A1, AFP, CYP19A1, CYP21A2, INSL3

GO Terms for genes affiliated with Leydig Cell Tumor

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Biological processes related to Leydig Cell Tumor according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1regulation of cell cycleGO:00517269.7DICER1, INHA
2progesterone metabolic processGO:00424489.6AFP, CYP17A1
3steroid biosynthetic processGO:00066949.5CYP17A1, CYP19A1
4glucocorticoid biosynthetic processGO:00067049.4CYP17A1, CYP21A2
5sterol metabolic processGO:00161259.2CYP21A2, CYP19A1, CYP17A1
6steroid metabolic processGO:00082029.2CYP21A2, CYP19A1, CYP17A1
7adrenal gland developmentGO:00303259.1NR5A1, CYP17A1
8xenobiotic metabolic processGO:00068059.0CYP21A2, CYP19A1, CYP17A1
9male gonad developmentGO:00085849.0INSL3, INHA, NR5A1
10cell-cell signalingGO:00072678.5NR5A1, INHA, INSL3

Molecular functions related to Leydig Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051799.6INSL3, INHA
2oxygen bindingGO:00198259.3CYP17A1, CYP19A1
3heme bindingGO:00200379.0CYP17A1, CYP19A1, CYP21A2
4iron ion bindingGO:00055068.9CYP21A2, CYP19A1, CYP17A1

Products for genes affiliated with Leydig Cell Tumor

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Sources for Leydig Cell Tumor

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet