MCID: LYD001
MIFTS: 54

Leydig Cell Tumor malady

Cancer diseases category

Summaries for Leydig Cell Tumor

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Wikipedia:63 Leydig cell tumour, also Leydig cell tumor (US spelling), (testicular) interstitial cell tumour and... more...

MalaCards: Leydig Cell Tumor, also known as leydig cell neoplasm, is related to sertoli-leydig cell tumor and sertoli cell tumor. An important gene associated with Leydig Cell Tumor is DICER1 (dicer 1, ribonuclease type III), and among its related pathways are Mineralocorticoid biosynthesis and Metabolism of steroid hormones and vitamin D. The compounds estrogen and dmrt have been mentioned in the context of this disorder. Affiliated tissues include testis, ovary and prostate, and related mouse phenotypes are endocrine/exocrine gland and tumorigenesis.

Aliases & Classifications for Leydig Cell Tumor

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

leydig cell tumor 8 10 44 60
leydig cell neoplasm 8


External Ids:

Disease Ontology8 DOID:2696
NCIt39 C3188
SNOMED-CT56 189739005, 45002009
MeSH34 D007984

Related Diseases for Leydig Cell Tumor

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17GeneCards, 18GeneDecks
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Diseases in the Leydig Cell Tumor family:

Malignant Leydig Cell Tumor

Diseases related to Leydig Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 162)
idRelated DiseaseScoreTop Affiliating Genes
1sertoli-leydig cell tumor31.7KRT7, PGR, INHA, MUC1, AFP, WT1
2sertoli cell tumor31.7PGR, INHA, CYP19A1, MUC1, CALB2
3gynecomastia30.9SRY, PGR, INHA, CYP17A1, CYP19A1
4congenital adrenal hyperplasia30.7SRY, CYP21A2, CYP17A1, CYP19A1, NR0B1, NR5A1
5androgen insensitivity syndrome30.7SRY
6sarcoma30.6MUC1, MYOG, WT1, CALB2
7hyperandrogenism30.6CYP21A2, CYP17A1, CYP19A1, LHCGR, HSD3BP4, INSL3
8cystadenoma30.5KRT7, INHA
9adrenal rest tumor30.5NR5A1, CYP21A2
10cryptorchidism30.5WT1, NR5A1, CYP19A1, INSL3, SRY
11amenorrhea30.4SRY
12rhabdomyosarcoma30.4INHA, MYOG, WT1, CALB2
13adenocarcinoma30.4CALB2, WT1, AFP, NR5A1, MUC1, CYP21A2
14adenoma30.4HSD3BP4, LHCGR, CALB2, NR5A1, NR0B1, MUC1
1521-hydroxylase deficiency30.1CYP21A2, INHA
16adrenal adenoma30.1CYP19A1, CYP17A1, CYP21A2
17choriocarcinoma30.1HSD3BP4, AFP, NR5A1, CYP19A1, INHA
18klinefelter's syndrome30.1NR5A1, NR0B1, CYP19A1, CYP21A2, INHA
19pseudohermaphroditism30.1CYP19A1, WT1, LHCGR, CYP17A1, SRY
20endometrial carcinoma30.1CALB2, CYP19A1, CYP17A1, INHA, PGR, KRT7
21prostate cancer30.1HSD3BP4, NR0B1, CYP19A1, CYP17A1, INHA, SRY
22infertility30.1HSD3BP4, LHCGR, SRY, INSL3, INHA, CYP21A2
23breast cancer30.1LHCGR, TNFSF14, NR5A1, NR0B1, MUC1, CYP19A1
24malignant leydig cell tumor10.8
25testicular leydig cell tumor10.8
26hypercalcemia10.6
27malignant sertoli-leydig cell tumor10.4
28malignant testicular leydig cell tumor10.3
29mature teratoma10.3
30goiter, multinodular 1, with or without sertoli-leydig cell tumors10.3
31ovarian malignant sertoli-leydig cell tumor10.3
32multinodular goiter10.3
33malignant sertoli cell tumor10.3
34cervicitis10.3
35goiter10.3
36ovarian cystadenoma10.3
37ovarian disease10.3
38rete testis adenocarcinoma10.1
39unilateral retinoblastoma10.1
40renal agenesis10.1
41tuberous sclerosis10.1
42mucinous adenocarcinoma10.1
43breast adenoma10.1
44breast disease10.1
45cystic teratoma10.1
46dysgerminoma of ovary10.1
47impotence10.1
48islet cell tumor10.1
49mediastinitis10.1
50ovary adenocarcinoma10.1

Graphical network of the top 20 diseases related to Leydig Cell Tumor:



Diseases related to leydig cell tumor

Clinical Features for Leydig Cell Tumor

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Drugs & Therapeutics for Leydig Cell Tumor

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Leydig Cell Tumor

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Anatomical Context for Leydig Cell Tumor

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32MalaCards
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MalaCards organs/tissues related to Leydig Cell Tumor:

32
Testis, Ovary, Prostate, Pituitary, Breast, Colon, Endothelial, Thyroid, Skeletal muscle, Lung, Liver, Bone, Testes

Animal Models for Leydig Cell Tumor or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Leydig Cell Tumor:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.3SRY, INHA, AFP, WT1, LHCGR
2MP:000200610.2AFP, NR0B1, MUC1, INHA, PGR, DICER1
3MP:000537610.1LHCGR, DICER1, AFP, NR5A1, NR0B1, MYOG
4MP:00053899.9NR5A1, AFP, DICER1, WT1, LHCGR, NR0B1
5MP:00028739.9CALB2, WT1, DICER1, NR5A1, MYOG, MUC1
6MP:00053869.6LHCGR, CALB2, DICER1, AFP, NR5A1, MYOG

Publications for Leydig Cell Tumor

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50PubMed
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Articles related to Leydig Cell Tumor:

(show top 50)    (show all 390)
idTitleAuthorsYear
1
A leydig cell tumor of the ovary resulting in extreme hyperandrogenism, erythrocytosis, and recurrent pulmonary embolism. (24152686)
2014
2
Long-term follow-up using testicle-sparing surgery for Leydig cell tumor. (23317518)
2013
3
Virilization due to androgen hypersecretion in a patient with ovarian leydig cell tumor: diagnostic and psychosocial implications. (23770793)
2013
4
Sertoli-Leydig cell tumor of the ovary: analysis of a single institution database. (22691037)
2013
5
Poorly differentiated ovarian sertoli-leydig cell tumor in a 16-year-old single woman: a case report and literature review. (23878752)
2013
6
Testicular adrenal rest "tumor" or Leydig cell tumor? A report of a challenging case with literature review. (23984262)
2013
7
Leydig cell tumor in two brothers with congenital adrenal hyperplasia due to 11-I^ hydroxylase deficiency: a case report. (21259051)
2012
8
The case reported as bilateral Sertoli-Leydig cell tumors in a 61-year-old woman with uterine aplasia may instead represent complete androgen insensitivity syndrome. (21623193)
2011
9
Postpartum hemorrhage from ruptured Sertoli-Leydig cell tumor: a case report. (21043371)
2010
10
Klinefelter syndrome with leydig cell tumor/hyperplasia. (20498565)
2010
11
Farnesoid X receptor, through the binding with steroidogenic factor 1-responsive element, inhibits aromatase expression in tumor Leydig cells. (20026603)
2010
12
Role of dosage-sensitive sex reversal, adrenal hypoplasia congenita, critical region on the X chromosome, gene 1 in protein kinase A- and protein kinase C-mediated regulation of the steroidogenic acute regulatory protein expression in mouse Leydig tumor cells: mechanism of action. (18787026)
2009
13
Study on the mechanism of trichlorfon-induced inhibition of progesterone synthesis in mouse leydig tumor cells (MLTC-1). (17350742)
2007
14
A malignant Leydig cell tumor of the testis. (16868700)
2006
15
A novel targeted therapy of Leydig and granulosa cell tumors through the luteinizing hormone receptor using a hecate-chorionic gonadotropin beta conjugate in transgenic mice. (15967102)
2005
16
Human endocrine gland-derived vascular endothelial growth factor: expression early in development and in Leydig cell tumors suggests roles in normal and pathological testis angiogenesis. (15292351)
2004
17
Leydig cell tumor of the testis. New cases and review of the current literature. (15510988)
2004
18
Incidental bilateral leydig cell tumor of the testes. (14512655)
2003
19
Sequestration of connexin43 in the early endosomes: an early event of Leydig cell tumor progression. (14639657)
2003
20
Occult Leydig cell tumor in a patient with gynecomastia. (11497478)
2001
21
Sertoli-Leydig cell tumor. (11205710)
2001
22
Leydig cell tumor, mature teratoma, and nongestational choriocarcinoma in a single ovary. (10808019)
2000
23
Cushing syndrome as the presenting feature of metastatic Leydig cell tumor of the testis. (10869651)
2000
24
Molecular mechanisms of thyroid hormone-stimulated steroidogenesis in mouse leydig tumor cells. Involvement of the steroidogenic acute regulatory (StAR) protein. (10026215)
1999
25
Suppression of carcass weight loss in cachexia in rats bearing Leydig cell tumor by the novel compound NO-1886, a lipoprotein lipase activator. (9440486)
1998
26
A peptidomimetic antagonist of the integrin alpha(v)beta3 inhibits Leydig cell tumor growth and the development of hypercalcemia of malignancy. (9581835)
1998
27
Presence of 17 beta-hydroxysteroid dehydrogenase type 3 messenger ribonucleic acid transcript in an ovarian Sertoli-Leydig cell tumor. (9314929)
1997
28
A virilizing Leydig cell tumor of the ovary associated with stromal hyperplasia under gonadotropin control. (9492110)
1997
29
Gynecomastia and Leydig cell tumor]. (9235082)
1997
30
Clinically occult Leydig cell tumor in a cryptorchid man. Report of a case presenting with unilateral gynecomastia and impotence. (9358228)
1997
31
Ovarian Sertoli-Leydig cell tumor in an amenorrheic hirsute patient. (8828265)
1996
32
Ovarian Sertoli-Leydig cell tumor with retiform pattern. (8771159)
1995
33
Regulation of parathyroid hormone-related peptide production in vitro by the rat hypercalcemic Leydig cell tumor H-500. (8462465)
1993
34
Leydig cell tumor: a case report with reference to its endocrinological features. (8375456)
1993
35
Isosexual male precocity due to a Leydig cell tumor. (1291502)
1992
36
Regulation of steroidogenesis in subclones of the MA-10 mouse Leydig tumor cell line. (1691116)
1990
37
Biphasic regulation of the messenger ribonucleic acid coding for the estrogen receptor by cyclic adenosine 3':5'-monophosphate in tumor Leydig cells. (2154326)
1990
38
Sertoli-Leydig cell tumor associated with a mature cystic teratoma in a single ovary. (2587573)
1989
39
Ovarian Sertoli-Leydig cell tumor with elevated serum alpha-fetoprotein. (2467733)
1989
40
An unusual hormone pattern in a virilized woman affected by Sertoli-Leydig cell tumor. Report of a case. (2694756)
1989
41
Leydig cell tumor of testis with adipose metaplasia. (2504261)
1989
42
A stromal Leydig cell tumor of the ovary occurring in a pregnant 15-year-old girl. Ultrastructural findings. (2824014)
1987
43
Leydig cell tumor of the testis. Four new cases. (3548279)
1986
44
Steroid biosynthesis in the Sertoli-Leydig cell tumor tissue of the human ovary; enzymhistochemical and immunohistochemical studies. (6425925)
1984
45
Characterization of estrogen receptors in various mouse Leydig cell tumor lines. (679191)
1978
46
Light and electron microscopic study of an intermediate sertoli-leydig cell tumor with a review of literatures in Japan. (1026031)
1976
47
Cultivation of the erythrocytic stages of Plasmodium berghei in Leydig cell tumor cultures. (793226)
1976
48
Growth and composition of a transplantable murine Leydig cell tumor. (1159839)
1975
49
Ovarian stromal tumors containing Leydig cells. II. Pure Leydig cell tumor, non-hilar type. (4751925)
1973
50
Ultrastructure of ovarian stromal cell tumors. Sertoli-Leydig cell tumor and lipid cell tumor. (5681434)
1968

Genetic Variations for Leydig Cell Tumor

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Expression for genes affiliated with Leydig Cell Tumor

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Leydig Cell Tumor

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Pathways for genes affiliated with Leydig Cell Tumor

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53Reactome, 37NCBI BioSystems Database, 29KEGG
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Compounds for genes affiliated with Leydig Cell Tumor

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Leydig Cell Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 96)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7CALB2, NR5A1, MYOG
2dmrt4410.7SRY, NR0B1, NR5A1, WT1
3leuprolide acetate4410.7PGR, CYP19A1, LHCGR, CYP21A2
4clomiphene citrate4410.7CYP21A2, CYP19A1, PGR, AFP
5forskolin44 49 1112.7CYP17A1, MYOG, WT1, LHCGR
6butyrate4410.7MYOG, CALB2
7pcb 1264410.7CYP19A1, CYP17A1, CYP21A2
817-hydroxyprogesterone44 2411.6CYP21A2, CYP19A1, CYP17A1, HSD3BP4
9dehydroepiandrosterone sulfate4410.6CYP17A1, CYP21A2, CYP19A1, NR5A1, HSD3BP4
10diethylstilbestrol44 28 1112.6NR5A1, CYP17A1, AFP, PGR, INSL3, CYP19A1
11dhea4410.6HSD3BP4, CYP19A1, NR5A1, CYP17A1, CYP21A2
12androstenedione44 2411.6HSD3BP4, CYP19A1, CYP17A1, INHA, CYP21A2
13b 7234410.6CALB2, AFP, MUC1, WT1, KRT7
14steroidal4410.6HSD3BP4, CYP17A1, PGR, CYP19A1
1517beta-hydroxysteroid4410.6CYP21A2, HSD3BP4, NR5A1, CYP17A1, CYP19A1, PGR
1617-hydroxypregnenolone4410.6HSD3BP4, CYP21A2, CYP17A1
17goserelin44 28 1112.6PGR, CYP19A1, LHCGR
18estrone44 28 11 2413.6AFP, HSD3BP4, PGR, CYP17A1, NR5A1, CYP19A1
19doca4410.6CYP17A1, HSD3BP4, CYP21A2
20ketoconazole44 28 11 2413.6CYP21A2, CYP17A1, HSD3BP4, CYP19A1
21progestin4410.6CYP19A1, MUC1, CYP17A1, PGR, LHCGR, HSD3BP4
22dihydrotestosterone44 28 11 2413.6MUC1, SRY, CYP19A1, PGR, CYP21A2, CYP17A1
23mifepristone44 59 28 1113.6AFP, CYP19A1, PGR, MUC1, HSD3BP4
24dexamethasone44 49 28 1113.5CYP21A2, HSD3BP4, CYP17A1, NR0B1, AFP
25gnrh4410.5CYP19A1, CYP17A1, CYP21A2, INHA, PGR, NR5A1
26acth4410.5CYP17A1, MUC1, NR0B1, NR5A1, CYP21A2, INHA
27buserelin44 28 1112.5LHCGR, CYP19A1, PGR
28hematoxylin4410.5KRT7, INHA, MUC1, CALB2
29mucicarmine4410.5KRT7, MUC1, CALB2
303beta-hydroxysteroid4410.5PGR, INHA, CYP21A2, CYP17A1, CYP19A1, NR5A1
31cyclic amp44 2411.4NR0B1, HSD3BP4, LHCGR, INSL3, INHA, CYP17A1
32paraffin4410.4WT1, AFP, CALB2, MUC1, PGR, KRT7
33cholesterol44 28 11 2413.4NR5A1, HSD3BP4, LHCGR, CYP21A2, CYP17A1, MUC1
34methotrexate44 49 1112.4KRT7, AFP, PGR, CYP19A1, MUC1
35cysteine4410.4MUC1, MYOG, NR0B1, SRY, PGR
36oligonucleotide4410.4CYP17A1, CYP21A2, WT1, AFP, SRY, MYOG
37threonine4410.4NR5A1, CYP21A2, CYP17A1, LHCGR, MUC1, WT1
38ribonucleic acid4410.4CYP17A1, LHCGR, WT1, NR5A1, MYOG, HSD3BP4
39retinoic acid44 2411.4MUC1, KRT7, PGR, CYP17A1, CYP19A1, MYOG
40estradiol44 11 2412.4CYP19A1, HSD3BP4, AFP, SRY, PGR, INHA
41chloramphenicol44 2 1112.3AFP, WT1, MUC1, CYP17A1, CYP21A2
42exemestane49 44 59 1113.3CYP19A1, PGR, CYP17A1
43bisphenol a4410.3CYP19A1, CYP17A1, PGR
44tyrosine4410.2MUC1, KRT7, SRY, CALB2, CYP21A2, AFP
45progesterone44 59 28 11 2414.2CYP21A2, PGR, KRT7, CYP17A1, CYP19A1, MUC1
46vegf4410.1WT1, PGR, MUC1, MYOG, AFP, KRT7
47steroid4410.1MYOG, NR0B1, NR5A1, AFP, WT1, CALB2
48testosterone44 59 11 2413.0CALB2, SRY, KRT7, PGR, INSL3, INHA
49serine449.9AFP, LHCGR, NR5A1, SRY, CYP21A2, CYP17A1
50zinc44 2410.8CYP17A1, SRY, NR0B1, NR5A1, AFP, WT1

GO Terms for genes affiliated with Leydig Cell Tumor

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16Gene Ontology
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Biological processes related to Leydig Cell Tumor according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of male gonad developmentGO:200002010.6SRY, NR5A1, WT1
2cellular response to gonadotropin stimulusGO:07137110.6LHCGR, WT1, CYP17A1
3sterol metabolic processGO:01612510.6CYP21A2, CYP17A1, CYP19A1
4negative regulation of female gonad developmentGO:200019510.6NR5A1, WT1
5adrenal gland developmentGO:03032510.5WT1, NR5A1, NR0B1, CYP17A1
6steroid biosynthetic processGO:00669410.5NR0B1, CYP19A1, CYP17A1
7progesterone metabolic processGO:04244810.5CYP17A1, AFP
8steroid metabolic processGO:00820210.5CYP19A1, CYP17A1, CYP21A2
9glucocorticoid biosynthetic processGO:00670410.4CYP17A1, CYP21A2
10male gonad developmentGO:00858410.4SRY, INSL3, INHA, NR0B1, NR5A1, WT1
11ovulation from ovarian follicleGO:00154210.4AFP, PGR
12Leydig cell differentiationGO:03332710.4CYP17A1, NR0B1
13cell-cell signalingGO:00726710.2NR5A1, INHA, INSL3, PGR
14male sex determinationGO:03023810.1SRY, NR0B1

Molecular functions related to Leydig Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:00510210.3PGR, INSL3, INHA, TNFSF14
2ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:00487910.2PGR, NR0B1, NR5A1
3steroid hormone receptor activityGO:00370710.0NR5A1, NR0B1, PGR

Products for genes affiliated with Leydig Cell Tumor

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Sources for Leydig Cell Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet