MCID: LYD001
MIFTS: 54

Leydig Cell Tumor malady

Cancer diseases category

Summaries for Leydig Cell Tumor

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Wikipedia:63 Leydig cell tumour, also Leydig cell tumor (US spelling), (testicular) interstitial cell tumour and... more...

MalaCards: Leydig Cell Tumor, also known as leydig cell neoplasm, is related to sertoli-leydig cell tumor and sertoli cell tumor. An important gene associated with Leydig Cell Tumor is DICER1 (dicer 1, ribonuclease type III), and among its related pathways are Mineralocorticoid biosynthesis and Metabolism of steroid hormones and vitamin D. The compounds estrogen and dmrt have been mentioned in the context of this disorder. Affiliated tissues include testis, ovary and prostate, and related mouse phenotypes are endocrine/exocrine gland and tumorigenesis.

Aliases & Classifications for Leydig Cell Tumor

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

leydig cell tumor 8 10 44 60
leydig cell neoplasm 8


External Ids:

Disease Ontology8 DOID:2696
NCIt39 C3188
SNOMED-CT56 189739005, 45002009
MeSH34 D007984

Related Diseases for Leydig Cell Tumor

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17GeneCards, 18GeneDecks
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Diseases in the Leydig Cell Tumor family:

Malignant Leydig Cell Tumor

Diseases related to Leydig Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 162)
idRelated DiseaseScoreTop Affiliating Genes
1sertoli-leydig cell tumor31.7KRT7, PGR, INHA, MUC1, AFP, WT1
2sertoli cell tumor31.7PGR, INHA, CYP19A1, MUC1, CALB2
3gynecomastia30.9SRY, PGR, INHA, CYP17A1, CYP19A1
4congenital adrenal hyperplasia30.7SRY, CYP21A2, CYP17A1, CYP19A1, NR0B1, NR5A1
5androgen insensitivity syndrome30.7SRY
6sarcoma30.6MUC1, MYOG, WT1, CALB2
7hyperandrogenism30.6CYP21A2, CYP17A1, CYP19A1, LHCGR, HSD3BP4, INSL3
8cystadenoma30.5KRT7, INHA
9adrenal rest tumor30.5NR5A1, CYP21A2
10cryptorchidism30.5WT1, NR5A1, CYP19A1, INSL3, SRY
11amenorrhea30.4SRY
12rhabdomyosarcoma30.4INHA, MYOG, WT1, CALB2
13adenocarcinoma30.4CALB2, WT1, AFP, NR5A1, MUC1, CYP21A2
14adenoma30.4HSD3BP4, LHCGR, CALB2, NR5A1, NR0B1, MUC1
1521-hydroxylase deficiency30.1CYP21A2, INHA
16adrenal adenoma30.1CYP19A1, CYP17A1, CYP21A2
17choriocarcinoma30.1HSD3BP4, AFP, NR5A1, CYP19A1, INHA
18klinefelter's syndrome30.1NR5A1, NR0B1, CYP19A1, CYP21A2, INHA
19pseudohermaphroditism30.1CYP19A1, WT1, LHCGR, CYP17A1, SRY
20endometrial carcinoma30.1CALB2, CYP19A1, CYP17A1, INHA, PGR, KRT7
21prostate cancer30.1HSD3BP4, NR0B1, CYP19A1, CYP17A1, INHA, SRY
22infertility30.1HSD3BP4, LHCGR, SRY, INSL3, INHA, CYP21A2
23breast cancer30.1LHCGR, TNFSF14, NR5A1, NR0B1, MUC1, CYP19A1
24malignant leydig cell tumor10.8
25testicular leydig cell tumor10.8
26hypercalcemia10.6
27malignant sertoli-leydig cell tumor10.4
28malignant testicular leydig cell tumor10.3
29mature teratoma10.3
30goiter, multinodular 1, with or without sertoli-leydig cell tumors10.3
31ovarian malignant sertoli-leydig cell tumor10.3
32multinodular goiter10.3
33malignant sertoli cell tumor10.3
34cervicitis10.3
35goiter10.3
36ovarian cystadenoma10.3
37ovarian disease10.3
38rete testis adenocarcinoma10.1
39unilateral retinoblastoma10.1
40renal agenesis10.1
41tuberous sclerosis10.1
42mucinous adenocarcinoma10.1
43breast adenoma10.1
44breast disease10.1
45cystic teratoma10.1
46dysgerminoma of ovary10.1
47impotence10.1
48islet cell tumor10.1
49mediastinitis10.1
50ovary adenocarcinoma10.1

Graphical network of the top 20 diseases related to Leydig Cell Tumor:



Diseases related to leydig cell tumor

Clinical Features for Leydig Cell Tumor

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Drugs & Therapeutics for Leydig Cell Tumor

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Leydig Cell Tumor

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Anatomical Context for Leydig Cell Tumor

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32MalaCards
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MalaCards organs/tissues related to Leydig Cell Tumor:

32
Testis, Ovary, Prostate, Pituitary, Breast, Colon, Endothelial, Thyroid, Skeletal muscle, Lung, Liver, Bone, Testes

Animal Models for Leydig Cell Tumor or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Leydig Cell Tumor:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.3SRY, INHA, AFP, WT1, LHCGR
2MP:000200610.2AFP, NR0B1, MUC1, INHA, PGR, DICER1
3MP:000537610.1LHCGR, DICER1, AFP, NR5A1, NR0B1, MYOG
4MP:00053899.9NR5A1, AFP, DICER1, WT1, LHCGR, NR0B1
5MP:00028739.9CALB2, WT1, DICER1, NR5A1, MYOG, MUC1
6MP:00053869.6LHCGR, CALB2, DICER1, AFP, NR5A1, MYOG

Publications for Leydig Cell Tumor

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50PubMed
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Articles related to Leydig Cell Tumor:

(show top 50)    (show all 390)
idTitleAuthorsYear
1
Ovarian Sertoli-Leydig cell tumor: a report of seven cases and a review of the literature. (23173550)
2013
2
Sertoli-Leydig cell tumor of the ovary--morphological and immunohistochemical analysis. (22635079)
2012
3
Bilateral Leydig cell tumor of the testis: a case report. (23788910)
2012
4
First case of ovarian Sertoli-Leydig cell tumor after an allogeneic hematopoietic stem cell transplantation for Hodgkin's disease. (22633001)
2012
5
Nandrolone and stanozolol induce Leydig cell tumor proliferation through an estrogen-dependent mechanism involving IGF-I system. (21769864)
2012
6
Unusual presentation of a Leydig Cell Tumor. (20511687)
2010
7
A novel splice mutation in the TP53 gene associated with Leydig cell tumor and primitive neuroectodermal tumor. (17066464)
2008
8
Bilateral Leydig cell tumor in a six-year-old intersex goat affected by Polled Intersex Syndrome. (18192573)
2008
9
Sertoli-Leydig cell tumor: a rare ovarian neoplasm. Case report and review of literature. (18382911)
2008
10
Ovarian Sertoli-Leydig cell tumor with heterologous gastrointestinal epithelium as a source of alpha-fetoprotein: a case report. (18588618)
2008
11
Leydig cell tumor and hyperplasia: a review. (17672373)
2007
12
Leydig cell tumor after treatment for Ewing's sarcoma. (16526050)
2007
13
Re: Long-term follow-up and clinical characteristics of testicular Leydig cell tumor: experience with 24 cases. (17437857)
2007
14
Detection of aromatase and estrogen receptors (ERalpha, ERbeta1, ERbeta2) in human Leydig cell tumor. (17656605)
2007
15
Low concentrations mono-butyl phthalate stimulates steroidogenesis by facilitating steroidogenic acute regulatory protein expression in mouse Leydig tumor cells (MLTC-1). (16999944)
2006
16
Ovarian Leydig cell tumor in a peri-menopausal woman with severe hyperandrogenism and virilization. (16316848)
2005
17
Sertoli-Leydig cell tumor of the ovary. (15216408)
2004
18
Overexpression of the BCL2 gene in a Sertoli-Leydig cell tumor of the ovary: a pathologic and cytogenetic study. (14734221)
2004
19
Effects of amphetamine on steroidogenesis in MA-10 mouse Leydig tumor cells. (12597997)
2003
20
Absence of activating mutations in the hot spots of the LH receptor and Gs-alpha genes in Leydig cell tumors. (12150333)
2002
21
Male LH-independent sexual precocity in a 3.5-year-old boy caused by a somatic activating mutation of the LH receptor in a Leydig cell tumor. (11889161)
2002
22
Leydig cell tumor: a case report and review of the literature. (12004857)
2002
23
Intraoperative testosterone assay for virilizing ovarian tumor topographic assessment: report of a Leydig cell tumor of the ovary in a premenopausal woman with an adrenal incidentaloma. (12107203)
2002
24
Adult granulosa cell tumor of the ovary with foci of hepatic cell differentiation: a report of four cases and comparison with two cases of granulosa cell tumor with Leydig cells. (10478669)
1999
25
Activating mutation of the stimulatory G protein (gsp) as a putative cause of ovarian and testicular human stromal Leydig cell tumors. (9626141)
1998
26
Ovarian Sertoli-Leydig cell tumor: a SRY gene-independent pathway of pseudomale gonadal differentiation. (9343329)
1997
27
Regulation of function of the murine luteinizing hormone receptor promoter by cis- and trans-acting elements in mouse Leydig tumor cells. (8807640)
1996
28
Acute action of choriogonadotropin on Leydig tumor cells: changes in the topography of the mitochondrial peripheral-type benzodiazepine receptor. (8940407)
1996
29
Case report: congenital adrenal hyperplasia and malignant Leydig cell tumor. (7825657)
1995
30
Decreased stathmin expression does not affect the actions of human choriogonadotropin or epidermal growth factor in Leydig tumor cells. (7588235)
1995
31
Precocious puberty in a child with unilateral Leydig cell tumor of the testis following orchiopexy. (8105109)
1993
32
Finasteride blocks progesterone synthesis in MA-10 Leydig tumor cells. (8404636)
1993
33
Leydig cell tumor of intra-abdominal testis. (7903010)
1993
34
Ultrastructure and immunohistochemistry of a fetal-type Leydig cell tumor. (1448884)
1992
35
Attenuation of cAMP-mediated responses in MA-10 Leydig tumor cells by genetic manipulation of a cAMP-phosphodiesterase. (1713581)
1991
36
Steroid biosynthesis in the Sertoli-Leydig cell tumor: effects of insulin and luteinizing hormone. (2532472)
1989
37
An ovarian Sertoli-Leydig cell tumor with heterologous mucinous gland and NSE-immunoreactive-cell. (2457358)
1988
38
Ovarian and peripheral steroid hormones in a case of Sertoli-Leydig cell tumor. (2844882)
1988
39
Mixed Sertoli-Leydig cell tumor and rete testis adenocarcinoma in rats treated with CdCl2. (2834860)
1988
40
Effects of estrogen and tamoxifen on secretory glycoprotein synthesis in mouse Leydig cell tumor in vivo. (3178148)
1988
41
A transplantable rat Leydig cell tumor--3. Isoproterenol and prostaglandin E1 (PGE1) responsive adenylyl cyclase (AC). Regulatory effects of nucleotides and magnesium. (3702452)
1986
42
Leydig cell tumor of the testis: report of a case. (4077605)
1985
43
Sertoli-Leydig cell tumor of the ovary. (4019011)
1985
44
A transplantable rat Leydig cell tumor--1. LH and prolactin receptors and effects of the endocrine status of the host animal. (6096631)
1984
45
A Sertoli-Leydig cell tumor and pregnancy. Clinical, endocrine, radiologic, and electron microscopic findings. (6660923)
1983
46
Arrest of in vivo growth of a solid Leydig cell tumor by prolonged inhibition of mitochondrial protein synthesis. (6831447)
1983
47
Humoral hypercalcemia caused by a rat Leydig-cell tumor is associated with suppressed parathyroid hormone secretion and increased urinary cAMP excretion. (6307850)
1983
48
Leydig cell tumor induced hypercalcemia in the Fischer rat: morphometric and histochemical evidence for a humoral factor that activates osteoclasts. (7114164)
1982
49
Leydig cell tumor with gynecomastia. Report of a case with electron microscopy. (7460987)
1980
50
Leydig cell tumor of testis. (452218)
1979

Genetic Variations for Leydig Cell Tumor

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Expression for genes affiliated with Leydig Cell Tumor

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Leydig Cell Tumor

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Pathways for genes affiliated with Leydig Cell Tumor

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53Reactome, 37NCBI BioSystems Database, 29KEGG
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Compounds for genes affiliated with Leydig Cell Tumor

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Leydig Cell Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 96)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7CALB2, NR5A1, MYOG
2dmrt4410.7SRY, NR0B1, NR5A1, WT1
3leuprolide acetate4410.7PGR, CYP19A1, LHCGR, CYP21A2
4clomiphene citrate4410.7CYP21A2, CYP19A1, PGR, AFP
5forskolin44 49 1112.7CYP17A1, MYOG, WT1, LHCGR
6butyrate4410.7MYOG, CALB2
7pcb 1264410.7CYP19A1, CYP17A1, CYP21A2
817-hydroxyprogesterone44 2411.6CYP21A2, CYP19A1, CYP17A1, HSD3BP4
9dehydroepiandrosterone sulfate4410.6CYP17A1, CYP21A2, CYP19A1, NR5A1, HSD3BP4
10diethylstilbestrol44 28 1112.6NR5A1, CYP17A1, AFP, PGR, INSL3, CYP19A1
11dhea4410.6HSD3BP4, CYP19A1, NR5A1, CYP17A1, CYP21A2
12androstenedione44 2411.6HSD3BP4, CYP19A1, CYP17A1, INHA, CYP21A2
13b 7234410.6CALB2, AFP, MUC1, WT1, KRT7
14steroidal4410.6HSD3BP4, CYP17A1, PGR, CYP19A1
1517beta-hydroxysteroid4410.6CYP21A2, HSD3BP4, NR5A1, CYP17A1, CYP19A1, PGR
1617-hydroxypregnenolone4410.6HSD3BP4, CYP21A2, CYP17A1
17goserelin44 28 1112.6PGR, CYP19A1, LHCGR
18estrone44 28 11 2413.6AFP, HSD3BP4, PGR, CYP17A1, NR5A1, CYP19A1
19doca4410.6CYP17A1, HSD3BP4, CYP21A2
20ketoconazole44 28 11 2413.6CYP21A2, CYP17A1, HSD3BP4, CYP19A1
21progestin4410.6CYP19A1, MUC1, CYP17A1, PGR, LHCGR, HSD3BP4
22dihydrotestosterone44 28 11 2413.6MUC1, SRY, CYP19A1, PGR, CYP21A2, CYP17A1
23mifepristone44 59 28 1113.6AFP, CYP19A1, PGR, MUC1, HSD3BP4
24dexamethasone44 49 28 1113.5CYP21A2, HSD3BP4, CYP17A1, NR0B1, AFP
25gnrh4410.5CYP19A1, CYP17A1, CYP21A2, INHA, PGR, NR5A1
26acth4410.5CYP17A1, MUC1, NR0B1, NR5A1, CYP21A2, INHA
27buserelin44 28 1112.5LHCGR, CYP19A1, PGR
28hematoxylin4410.5KRT7, INHA, MUC1, CALB2
29mucicarmine4410.5KRT7, MUC1, CALB2
303beta-hydroxysteroid4410.5PGR, INHA, CYP21A2, CYP17A1, CYP19A1, NR5A1
31cyclic amp44 2411.4NR0B1, HSD3BP4, LHCGR, INSL3, INHA, CYP17A1
32paraffin4410.4WT1, AFP, CALB2, MUC1, PGR, KRT7
33cholesterol44 28 11 2413.4NR5A1, HSD3BP4, LHCGR, CYP21A2, CYP17A1, MUC1
34methotrexate44 49 1112.4KRT7, AFP, PGR, CYP19A1, MUC1
35cysteine4410.4MUC1, MYOG, NR0B1, SRY, PGR
36oligonucleotide4410.4CYP17A1, CYP21A2, WT1, AFP, SRY, MYOG
37threonine4410.4NR5A1, CYP21A2, CYP17A1, LHCGR, MUC1, WT1
38ribonucleic acid4410.4CYP17A1, LHCGR, WT1, NR5A1, MYOG, HSD3BP4
39retinoic acid44 2411.4MUC1, KRT7, PGR, CYP17A1, CYP19A1, MYOG
40estradiol44 11 2412.4CYP19A1, HSD3BP4, AFP, SRY, PGR, INHA
41chloramphenicol44 2 1112.3AFP, WT1, MUC1, CYP17A1, CYP21A2
42exemestane49 44 59 1113.3CYP19A1, PGR, CYP17A1
43bisphenol a4410.3CYP19A1, CYP17A1, PGR
44tyrosine4410.2MUC1, KRT7, SRY, CALB2, CYP21A2, AFP
45progesterone44 59 28 11 2414.2CYP21A2, PGR, KRT7, CYP17A1, CYP19A1, MUC1
46vegf4410.1WT1, PGR, MUC1, MYOG, AFP, KRT7
47steroid4410.1MYOG, NR0B1, NR5A1, AFP, WT1, CALB2
48testosterone44 59 11 2413.0CALB2, SRY, KRT7, PGR, INSL3, INHA
49serine449.9AFP, LHCGR, NR5A1, SRY, CYP21A2, CYP17A1
50zinc44 2410.8CYP17A1, SRY, NR0B1, NR5A1, AFP, WT1

GO Terms for genes affiliated with Leydig Cell Tumor

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16Gene Ontology
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Biological processes related to Leydig Cell Tumor according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of male gonad developmentGO:200002010.6SRY, NR5A1, WT1
2cellular response to gonadotropin stimulusGO:07137110.6LHCGR, WT1, CYP17A1
3sterol metabolic processGO:01612510.6CYP21A2, CYP17A1, CYP19A1
4negative regulation of female gonad developmentGO:200019510.6NR5A1, WT1
5adrenal gland developmentGO:03032510.5NR0B1, WT1, NR5A1, CYP17A1
6steroid biosynthetic processGO:00669410.5NR0B1, CYP19A1, CYP17A1
7progesterone metabolic processGO:04244810.5CYP17A1, AFP
8steroid metabolic processGO:00820210.5CYP21A2, CYP19A1, CYP17A1
9ovulation from ovarian follicleGO:00154210.4AFP, PGR
10glucocorticoid biosynthetic processGO:00670410.4CYP21A2, CYP17A1
11male gonad developmentGO:00858410.4NR5A1, NR0B1, INHA, INSL3, LHCGR, SRY
12Leydig cell differentiationGO:03332710.4CYP17A1, NR0B1
13cell-cell signalingGO:00726710.2INSL3, INHA, NR5A1, PGR
14male sex determinationGO:03023810.1SRY, NR0B1

Molecular functions related to Leydig Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:00510210.3PGR, INSL3, INHA, TNFSF14
2ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:00487910.2NR5A1, NR0B1, PGR
3steroid hormone receptor activityGO:00370710.0PGR, NR5A1, NR0B1

Products for genes affiliated with Leydig Cell Tumor

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Sources for Leydig Cell Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet