MCID: LYD001
MIFTS: 47

Leydig Cell Tumor

Categories: Cancer diseases

Aliases & Classifications for Leydig Cell Tumor

MalaCards integrated aliases for Leydig Cell Tumor:

Name: Leydig Cell Tumor 12 51 41 14 69
Leydig Cell Tumor, Benign 69
Leydig Cell Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2696
MeSH 41 D007984
NCIt 46 C3188
SNOMED-CT 64 189739005 45002009

Summaries for Leydig Cell Tumor

MalaCards based summary : Leydig Cell Tumor, also known as leydig cell tumor, benign, is related to sertoli-leydig cell tumor and testicular leydig cell tumor. An important gene associated with Leydig Cell Tumor is LHCGR (Luteinizing Hormone/Choriogonadotropin Receptor), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Prolactin Signaling Pathway. The drugs Methyltestosterone and Testosterone have been mentioned in the context of this disorder. Affiliated tissues include testis, ovary and endothelial, and related phenotypes are behavior/neurological and endocrine/exocrine gland

Related Diseases for Leydig Cell Tumor

Diseases in the Leydig Cell Tumor family:

Malignant Leydig Cell Tumor

Diseases related to Leydig Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 127)
# Related Disease Score Top Affiliating Genes
1 sertoli-leydig cell tumor 34.4 AFP INSL3
2 testicular leydig cell tumor 32.0 CYP11A1 CYP17A1 CYP21A2 ESR1 STAR
3 gynecomastia 30.4 CYP19A1 ESR1
4 hyperandrogenism 30.1 CYP17A1 CYP19A1 CYP21A2
5 precocious puberty 30.1 CYP19A1 CYP21A2 LHCGR
6 pseudohermaphroditism 29.8 CYP17A1 CYP19A1 LHCGR
7 infertility 29.7 CYP19A1 INSL3 LHCGR
8 adrenal adenoma 29.4 CYP11A1 CYP17A1 CYP21A2
9 lipoid congenital adrenal hyperplasia 29.2 CYP11A1 CYP17A1 CYP21A2 STAR
10 goiter, multinodular 1, with or without sertoli-leydig cell tumors 12.4
11 malignant leydig cell tumor 12.3
12 malignant sertoli-leydig cell tumor of the ovary 12.3
13 malignant testicular leydig cell tumor 12.1
14 malignant sertoli-leydig cell tumor 12.1
15 penis agenesis 10.4 CYP17A1 LHCGR
16 testotoxicosis 10.3 CYP19A1 LHCGR
17 precocious puberty, male-limited 10.3 CYP19A1 LHCGR
18 cytochrome p450 oxidoreductase deficiency 10.3 CYP17A1 CYP21A2
19 progesterone-receptor positive breast cancer 10.2 CYP19A1 ESR1
20 alpha-fetoprotein deficiency 10.2
21 infant gynecomastia 10.2
22 reproductive organ benign neoplasm 10.2 AFP ESR1
23 gender identity disorder 10.2 CYP19A1 ESR1
24 mycetoma 10.2 CYP17A1 CYP19A1
25 hypercalcemia, infantile, 1 10.2
26 endometriosis of ovary 10.2 CYP19A1 ESR1
27 endometrial disease 10.2 CYP19A1 ESR1
28 estrogen resistance 10.2 CYP19A1 ESR1
29 aromatase deficiency 10.2 CYP19A1 ESR1
30 tubular adenocarcinoma 10.2 AFP ESR1
31 sclerosing hepatic carcinoma 10.2 AFP PTHLH
32 prostatic hypertrophy 10.1 CYP19A1 ESR1
33 alopecia, androgenetic, 1 10.1 CYP19A1 CYP21A2
34 liver sarcoma 10.1 AFP PTHLH
35 androgen insensitivity syndrome 10.1
36 chorioangioma 10.1 AFP PTHLH
37 acute adrenal insufficiency 10.1 CYP11A1 CYP21A2
38 uterine sarcoma 10.1 CYP19A1 ESR1
39 sex cord-gonadal stromal tumor 10.1 AFP CYP19A1
40 breast fibroadenoma 10.1 CYP19A1 ESR1
41 cryptorchidism, unilateral or bilateral 10.1
42 complete androgen insensitivity syndrome 10.1
43 adrenal cortical hypofunction 10.1 CYP11A1 CYP21A2
44 hemangioma of intra-abdominal structure 10.1 AFP PTHLH
45 estrogen excess 10.1 CYP19A1 ESR1 LHCGR
46 dysgerminoma of ovary 10.1 AFP PTHLH
47 mammographic density 10.0 CYP17A1 CYP19A1 ESR1
48 multinodular goiter 10.0
49 sarcoma 10.0
50 goiter 10.0

Graphical network of the top 20 diseases related to Leydig Cell Tumor:



Diseases related to Leydig Cell Tumor

Symptoms & Phenotypes for Leydig Cell Tumor

MGI Mouse Phenotypes related to Leydig Cell Tumor:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.03 PTHLH ESR1 AFP CYP11A1 INSL3 CYP17A1
2 endocrine/exocrine gland MP:0005379 9.97 ESR1 AFP CYP11A1 INSL3 LHCGR CYP19A1
3 cellular MP:0005384 9.95 CYP19A1 ESR1 CYP11A1 INSL3 CYP17A1 LHCGR
4 homeostasis/metabolism MP:0005376 9.92 PTHLH ESR1 AFP CYP11A1 CYP17A1 LHCGR
5 adipose tissue MP:0005375 9.85 PTHLH ESR1 CYP17A1 LHCGR CYP19A1
6 liver/biliary system MP:0005370 9.65 ESR1 AFP CYP11A1 LHCGR CYP19A1
7 reproductive system MP:0005389 9.61 ESR1 AFP CYP11A1 INSL3 CYP17A1 LHCGR
8 renal/urinary system MP:0005367 9.55 CYP19A1 PTHLH ESR1 CYP17A1 LHCGR
9 skeleton MP:0005390 9.1 CYP19A1 ESR1 INSL3 CYP17A1 LHCGR PTHLH

Drugs & Therapeutics for Leydig Cell Tumor

Drugs for Leydig Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methyltestosterone Approved Phase 2, Phase 3 58-18-4 6010
2
Testosterone Approved, Investigational Phase 2, Phase 3 58-22-0 6013
3 Castor oil Approved, Investigational, Nutraceutical, Vet_approved Phase 2, Phase 3
4 Anabolic Agents Phase 2, Phase 3
5 Androgens Phase 2, Phase 3
6 Antineoplastic Agents, Hormonal Phase 2, Phase 3
7 Cathartics Phase 2, Phase 3
8 Gastrointestinal Agents Phase 2, Phase 3
9 Hormone Antagonists Phase 2, Phase 3
10 Hormones Phase 2, Phase 3
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
12 Laxatives Phase 2, Phase 3
13 Testosterone 17 beta-cypionate Phase 2, Phase 3
14
Testosterone enanthate Phase 2, Phase 3 315-37-7 9416
15 Testosterone undecanoate Phase 2, Phase 3
16 Castor Nutraceutical Phase 2, Phase 3
17
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
18
Carboplatin Approved Phase 2,Phase 1 41575-94-4 10339178 38904 498142
19
Bleomycin Approved, Investigational Phase 2 11056-06-7 5360373
20
Cisplatin Approved Phase 2 15663-27-1 2767 441203 84093
21
Etoposide Approved Phase 2 33419-42-0 36462
22
Bevacizumab Approved, Investigational Phase 2 216974-75-3
23 Albumin-Bound Paclitaxel Phase 2
24 Antimitotic Agents Phase 2
25 Antineoplastic Agents, Phytogenic Phase 2
26 Anti-Bacterial Agents Phase 2
27 Antibiotics, Antitubercular Phase 2
28 Etoposide phosphate Phase 2
29 Topoisomerase Inhibitors Phase 2
30 Angiogenesis Inhibitors Phase 2
31 Angiogenesis Modulating Agents Phase 2
32 Antibodies Phase 2
33 Antibodies, Monoclonal Phase 2
34 Endothelial Growth Factors Phase 2
35 Immunoglobulins Phase 2
36 Mitogens Phase 2
37
Gemcitabine Approved Phase 1 95058-81-4 60750
38 Anti-Infective Agents Phase 1
39 Antimetabolites Phase 1
40 Antimetabolites, Antineoplastic Phase 1
41 Antiviral Agents Phase 1
42 Immunosuppressive Agents Phase 1
43
Cyclophosphamide Approved, Investigational 50-18-0, 6055-19-2 2907
44
Dactinomycin Approved, Investigational 50-76-0 457193 2019
45
Doxorubicin Approved, Investigational 23214-92-8 31703
46
Ifosfamide Approved 3778-73-2 3690
47
Vincristine Approved, Investigational 2068-78-2, 57-22-7 5978
48
Doxil Approved June 1999 31703
49 Isophosphamide mustard 0

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Androgen for Leydig Cell Proliferation Completed NCT01206270 Phase 2, Phase 3 Testosterone undecanoate;Castor Oil
2 Paclitaxel in Treating Patients With Ovarian Stromal Cancer Completed NCT00006227 Phase 2 Paclitaxel
3 Paclitaxel and Carboplatin or Bleomycin Sulfate, Etoposide Phosphate, and Cisplatin in Treating Patients With Advanced or Recurrent Sex Cord-Ovarian Stromal Tumors Recruiting NCT01042522 Phase 2 Carboplatin;Cisplatin;Etoposide Phosphate;Paclitaxel
4 Bevacizumab in Treating Patients With Recurrent Sex Cord-Stromal Tumors of the Ovary Active, not recruiting NCT00748657 Phase 2
5 Carboplatin, Gemcitabine Hydrochloride, and Stereotactic Body Radiation Therapy in Gynecological Cancer Completed NCT01652794 Phase 1 carboplatin;gemcitabine hydrochloride
6 Studying Genes in Samples From Younger Patients With Ovarian or Testicular Sex Cord Stromal Tumors Completed NCT01572467
7 Stress Reduction in Improving Quality of Life in Patients With Recurrent Gynecologic or Breast Cancer Completed NCT01764789
8 DICER1-related Pleuropulmonary Blastoma Cancer Predisposition Syndrome: A Natural History Study Recruiting NCT01247597
9 International PPB Registry for PPB, DICER1 and Associated Conditions Recruiting NCT03382158
10 Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome Recruiting NCT00565903

Search NIH Clinical Center for Leydig Cell Tumor

Cochrane evidence based reviews: leydig cell tumor

Genetic Tests for Leydig Cell Tumor

Anatomical Context for Leydig Cell Tumor

MalaCards organs/tissues related to Leydig Cell Tumor:

38
Testis, Ovary, Endothelial, Lung, Testes, Prostate, Pituitary

Publications for Leydig Cell Tumor

Articles related to Leydig Cell Tumor:

(show top 50) (show all 389)
# Title Authors Year
1
Testicular Estrogen-Secreting Leydig Cell Tumor in 18F-FDG PET/CT: An Incidental Detection in a Patient Treated by Chemotherapy for Hodgkin Lymphoma. ( 29166332 )
2018
2
Mitotane treatment in patients with metastatic testicular Leydig cell tumor associated with severe androgen excess. ( 29330226 )
2018
3
Familial multinodular goiter and Sertoli-Leydig cell tumors associated with a large intragenic in-frame<i>DICER1</i>deletion. ( 29187512 )
2018
4
Case report: an identical twin with Sertoli-Leydig cell tumor. ( 29366348 )
2018
5
Sertoli-Leydig Cell Tumor with Concurrent Rhabdomyosarcoma: Three Case Reports and a Review of the Literature. ( 28751916 )
2017
6
Leydig cell tumor in grey zone: A case report. ( 28419904 )
2017
7
Sertoli-Leydig cell tumor of the ovary masquerading as a mucinous adenocarcinoma: a frozen section pitfall. ( 29081925 )
2017
8
Ovarian Sertoli-Leydig Cell Tumor with Elevated Inhibin B as a Cause of Secondary Amenorrhea in an Adolescent with Germ Line DICER1 Mutation. ( 28502826 )
2017
9
Retiform Sertoli-Leydig Cell Tumor in a 38-Year-Old Woman: A Case Report, Retrospective Review, and Review of Current Literature. ( 28316852 )
2017
10
Leydig cell tumor of the testis, presenting with azoospermia. ( 29259494 )
2017
11
A Case Report: Ovarian Sertoli-Leydig Cell Tumor With Hyperestrogenism and Endometrial Hyperplasia in a Postmenopausal Woman. ( 28469526 )
2017
12
Leydig cell tumor in ovary of a German Shepherd bitch: An immunohistopathological study. ( 28473902 )
2017
13
DICER1 hotspot mutations in ovarian Sertoli-Leydig cell tumors: a potential association with androgenic effects. ( 27664536 )
2017
14
DICER1 Mutations Are Consistently Present in Moderately and Poorly Differentiated Sertoli-Leydig Cell Tumors. ( 28654427 )
2017
15
Leydig Cell Tumor of Testis in a Child: An Uncommon Presentation. ( 28694581 )
2017
16
Leydig cell tumor in the post-menopausal woman: case report and literature review. ( 28112699 )
2017
17
DICER1-related Sertoli-Leydig cell tumor and gynandroblastoma: Clinical and genetic findings from the International Ovarian and Testicular Stromal Tumor Registry. ( 29037807 )
2017
18
Incidental Leydig Cell Tumor in Patient with Hormone Resistant Prostate Cancer. ( 28443242 )
2017
19
An inguinal hernia with cryptorchidism with a Leydig cell tumor in an elderly man: A case report. ( 28171846 )
2017
20
Recurrent Sertoli-Leydig cell tumor of ovary in 8-year-old girl. ( 27334531 )
2016
21
Sertoli-Leydig cell tumor of the ovary: A diagnostic dilemma. ( 26937481 )
2016
22
A Rare Case of Intra-Endometrial Leiomyoma of Uterus Simulating Degenerated Submucosal Leiomyoma Accompanied by a Large Sertoli-Leydig Cell Tumor. ( 26847310 )
2016
23
Large moderately-differentiated ovarian Sertoli-Leydig cell tumor in a 13-year-old female: A case report. ( 26893701 )
2016
24
Fertility-sparing management and obstetric outcomes in a 20-year-old patient with a Sertoli-Leydig cell tumor of the ovary: A case report and review of the literature. ( 27446397 )
2016
25
Atypical Leydig Cell Tumor in Children: Report of 2 Cases. ( 27940757 )
2016
26
Recurrent ovarian Sertoli-Leydig cell tumor in a child with Peutz-Jeghers syndrome. ( 28101370 )
2016
27
Leydig cell tumor found incidentally during microscopic testicular sperm extraction in patient with mosaic Klinefelter syndrome: case report. ( 27523297 )
2016
28
Ovarian Sertoli-Leydig cell tumor with heterologous elements containing an unusual type of alpha-fetoprotein-producing cells. ( 27126717 )
2016
29
The co-occurrence of an ovarian Sertoli-Leydig cell tumor with a thyroid carcinoma is highly suggestive of a DICER1 syndrome. ( 26983701 )
2016
30
Sertoli - Leydig cell tumor with retiform areas and overgrowth of rhabdomyosarcomatous elements: case report and literature review. ( 27473538 )
2016
31
Leydig cell tumor of the testis with azoospermia and elevated delta4 androstenedione: case report. ( 27833751 )
2016
32
Leydig cell tumor incidentally detected by fused FDG-PET/MRI. ( 25636443 )
2015
33
Leydig cell tumor with lung metastasis diagnosed by lung biopsy. ( 26722493 )
2015
34
Cervical embryonal rhabdomyosarcoma and ovarian Sertoli-Leydig cell tumor with congenital absence of unilateral ovary. ( 26458643 )
2015
35
The oncogenic roles of DICER1 RNase IIIb domain mutations in ovarian Sertoli-Leydig cell tumors. ( 26408257 )
2015
36
Testicular Leydig Cell Tumor with Metachronous Lesions: Outcomes after Metastasis Resection and Cryoablation. ( 26525589 )
2015
37
Metastasized Leydig cell tumor in a dog. ( 26753337 )
2015
38
True Precocious Puberty Following Treatment of a Leydig Cell Tumor: Two Case Reports and Literature Review. ( 26579503 )
2015
39
Ovarian Sertoli-Leydig Cell Tumor with Predominant Heterologous Mucinous Differentiation and Foci of Hepatocytic Differentiation: Case Report and Review of The Literature. ( 26116602 )
2015
40
Leydig cell tumor of testis with indeterminate features. ( 26960466 )
2015
41
Alopecia and Hirsutism in a Postmenopausal Woman as the Presenting Complaint of Ovarian Hilus (Leydig) Cell Tumor. ( 25910403 )
2015
42
Leydig cell tumor in a patient with 49,XXXXY karyotype: a review of literature. ( 26160035 )
2015
43
Woman with virilizing congenital adrenal hyperplasia and Leydig cell tumor of the ovary. ( 24702195 )
2014
44
Sertoli-leydig cell tumor of ovary- a diagnostic dilemma. ( 24783104 )
2014
45
Sertoli-Leydig cell tumor in a 12-year-old girl: a review article and case report. ( 25027813 )
2014
46
Sertoli-Leydig cell tumors: hormonal profile after dynamic test with GnRH analogue: triptorelin represents a useful tool to evaluate tumoral hyperandrogenism. ( 25299229 )
2014
47
A leydig cell tumor of the ovary resulting in extreme hyperandrogenism, erythrocytosis, and recurrent pulmonary embolism. ( 24152686 )
2014
48
Testicular adrenal rest tumor mimicking leydig cell tumor in a patient with congenital adrenal hyperplasia. ( 24834391 )
2014
49
Ovarian Sertoli-Leydig cell tumor with heterologous elements of gastrointestinal type associated with elevated serum alpha-fetoprotein level: an unusual case and literature review. ( 25926909 )
2014
50
Metastatic relapse after initial clinical stage I testicular Leydig cell tumor. ( 24855728 )
2014

Variations for Leydig Cell Tumor

Expression for Leydig Cell Tumor

Search GEO for disease gene expression data for Leydig Cell Tumor.

Pathways for Leydig Cell Tumor

Pathways related to Leydig Cell Tumor according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.41 CYP11A1 CYP17A1 CYP21A2 STAR
2
Show member pathways
12.12 CYP17A1 ESR1 LHCGR
3 12.11 CYP11A1 CYP17A1 CYP19A1 STAR
4 11.74 INSL3 LHCGR PTHLH
5 11.51 CYP11A1 CYP21A2 STAR
6
Show member pathways
11.3 CYP11A1 CYP17A1 CYP19A1 CYP21A2 STAR
7
Show member pathways
11.27 CYP11A1 CYP17A1 CYP19A1 CYP21A2
8
Show member pathways
11.24 CYP17A1 CYP19A1
9 10.98 CYP19A1 LHCGR
10
Show member pathways
10.8 CYP17A1 CYP21A2
11 10.72 CYP11A1 CYP17A1 CYP19A1 LHCGR STAR
12 9.86 CYP19A1 ESR1

GO Terms for Leydig Cell Tumor

Biological processes related to Leydig Cell Tumor according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.84 CYP11A1 CYP17A1 CYP19A1 CYP21A2
2 steroid metabolic process GO:0008202 9.67 CYP11A1 CYP17A1 CYP21A2
3 male gonad development GO:0008584 9.61 ESR1 LHCGR STAR
4 androgen metabolic process GO:0008209 9.52 CYP19A1 ESR1
5 uterus development GO:0060065 9.51 CYP19A1 ESR1
6 estrogen biosynthetic process GO:0006703 9.48 CYP19A1 STAR
7 C21-steroid hormone biosynthetic process GO:0006700 9.46 CYP11A1 STAR
8 progesterone metabolic process GO:0042448 9.4 AFP CYP17A1
9 cellular response to gonadotropin stimulus GO:0071371 9.37 LHCGR STAR
10 glucocorticoid biosynthetic process GO:0006704 9.32 CYP17A1 CYP21A2
11 testosterone biosynthetic process GO:0061370 9.26 CYP19A1 STAR
12 sterol metabolic process GO:0016125 9.26 CYP11A1 CYP17A1 CYP19A1 CYP21A2
13 cellular response to luteinizing hormone stimulus GO:0071373 9.16 LHCGR STAR
14 steroid biosynthetic process GO:0006694 9.02 CYP11A1 CYP17A1 CYP19A1 CYP21A2 STAR

Molecular functions related to Leydig Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.67 CYP11A1 CYP17A1 CYP19A1 CYP21A2
2 lipid binding GO:0008289 9.61 CYP21A2 ESR1 STAR
3 iron ion binding GO:0005506 9.46 CYP11A1 CYP17A1 CYP19A1 CYP21A2
4 oxygen binding GO:0019825 9.4 CYP17A1 CYP19A1
5 steroid binding GO:0005496 9.32 CYP21A2 ESR1
6 steroid hydroxylase activity GO:0008395 9.26 CYP19A1 CYP21A2
7 heme binding GO:0020037 9.26 CYP11A1 CYP17A1 CYP19A1 CYP21A2
8 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 8.92 CYP11A1 CYP17A1 CYP19A1 CYP21A2

Sources for Leydig Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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