MCID: LYD001
MIFTS: 44

Leydig Cell Tumor

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Leydig Cell Tumor

MalaCards integrated aliases for Leydig Cell Tumor:

Name: Leydig Cell Tumor 12 52 42 14 69
Leydig Cell Tumor, Benign 69
Leydig Cell Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2696
MeSH 42 D007984
NCIt 47 C3188
SNOMED-CT 64 189739005 45002009
UMLS 69 C0023601

Summaries for Leydig Cell Tumor

MalaCards based summary : Leydig Cell Tumor, also known as leydig cell tumor, benign, is related to sertoli-leydig cell tumor and goiter, multinodular 1, with or without sertoli-leydig cell tumors. An important gene associated with Leydig Cell Tumor is LHCGR (Luteinizing Hormone/Choriogonadotropin Receptor), and among its related pathways/superpathways are Glucose / Energy Metabolism and Prolactin Signaling Pathway. The drugs Castor oil and Methyltestosterone have been mentioned in the context of this disorder. Affiliated tissues include ovary, testis and breast, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and behavior/neurological

Related Diseases for Leydig Cell Tumor

Diseases in the Leydig Cell Tumor family:

Malignant Leydig Cell Tumor

Diseases related to Leydig Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 132)
id Related Disease Score Top Affiliating Genes
1 sertoli-leydig cell tumor 12.5
2 goiter, multinodular 1, with or without sertoli-leydig cell tumors 12.3
3 malignant leydig cell tumor 12.2
4 testicular leydig cell tumor 12.2
5 malignant sertoli-leydig cell tumor of ovary 12.0
6 malignant testicular leydig cell tumor 11.9
7 malignant sertoli-leydig cell tumor 11.9
8 pepck 1 deficiency 10.6 CYP17A1 LHCGR
9 tetraamelia with pulmonary hypoplasia 10.6 CYP19A1 LHCGR
10 precocious puberty, male 10.6 CYP19A1 LHCGR
11 brenner tumor of the vagina 10.6 CYP17A1 ESR1
12 brenner tumor of ovary 10.6 CYP17A1 ESR1
13 waterhouse-friderichsen syndrome 10.5 AFP ESR1
14 dfna2 nonsyndromic hearing loss 10.5 CYP17A1 CYP21A2
15 her2-receptor positive breast cancer 10.5 CYP19A1 ESR1
16 osteogenesis imperfecta 10.5 CYP19A1 ESR1
17 hypersensitivity reaction type iii disease 10.5 AFP ESR1
18 perinatal jaundice due to hepatocellular damage 10.4 CYP19A1 ESR1
19 subglottis neoplasm 10.4 CYP19A1 ESR1
20 pineal gland cancer 10.4 AFP PTHLH
21 gastrointestinal system benign neoplasm 10.4 AFP ESR1
22 mycobacterium gordonae 10.4 CYP17A1 CYP19A1
23 parkinson disease, juvenile, type 2 10.4 CYP19A1 ESR1
24 aromatase excess syndrome 10.4 CYP19A1 ESR1
25 pigmented villonodular synovitis 10.4 AFP PTHLH
26 epilepsy, idiopathic generalized 11 10.4 CYP19A1 CYP21A2
27 rectosigmoid junction neoplasm 10.4 AFP PTHLH
28 ureter adenocarcinoma 10.3 AFP ESR1
29 esophagus sarcoma 10.3 CYP19A1 ESR1
30 tactile epilepsy 10.3 AFP PTHLH
31 vagina, absence of 10.3 CYP19A1 ESR1
32 intraventricular meningioma 10.3 CYP17A1 CYP19A1 LHCGR
33 hepatic veno-occlusive disease 10.3 AFP NR5A1
34 nasal cavity squamous cell carcinoma 10.2 AFP PTHLH
35 acute thyroiditis 10.2 CYP19A1 ESR1 LHCGR
36 panuveitis 10.2 CYP17A1 CYP21A2
37 breast disease 10.2 AFP CYP19A1 ESR1
38 gynecomastia 10.2
39 presenile dementia, kraepelin type 10.1 CYP19A1 CYP21A2 LHCGR
40 tooth disease 10.1 CYP17A1 LHCGR NR5A1
41 gastrojejunal ulcer 10.1 CYP17A1 CYP19A1 CYP21A2
42 weill-marchesani syndrome 10.1 CYP17A1 CYP19A1 CYP21A2
43 congenital adrenal hyperplasia 10.1
44 lacrimal gland mucoepidermoid carcinoma 10.1 ESR1 PTHLH
45 pelvic muscle wasting 10.1 CYP17A1 CYP19A1 CYP21A2
46 benign peritoneal mesothelioma 10.1 CYP21A2 NR5A1
47 breast duct papilloma 10.1 CYP19A1 ESR1
48 progesterone-receptor positive breast cancer 10.1 CYP19A1 ESR1
49 glycerol kinase deficiency 10.1 NR5A1 STAR
50 hyperandrogenism 10.1

Graphical network of the top 20 diseases related to Leydig Cell Tumor:



Diseases related to Leydig Cell Tumor

Symptoms & Phenotypes for Leydig Cell Tumor

GenomeRNAi Phenotypes related to Leydig Cell Tumor according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.36 CYP21A2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.36 CYP21A2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.36 NR5A1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-184 9.36 CYP11A1 CYP21A2 NR5A1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-203 9.36 CYP11A1 CYP21A2
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-206 9.36 CYP21A2
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.36 CYP21A2
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-28 9.36 CYP11A1

MGI Mouse Phenotypes related to Leydig Cell Tumor:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.03 AFP CYP11A1 CYP17A1 CYP19A1 ESR1 LHCGR
2 endocrine/exocrine gland MP:0005379 9.97 LHCGR NR5A1 PTHLH STAR AFP CYP11A1
3 cellular MP:0005384 9.95 CYP11A1 CYP17A1 CYP19A1 ESR1 LHCGR NR5A1
4 homeostasis/metabolism MP:0005376 9.91 AFP CYP11A1 CYP17A1 CYP19A1 ESR1 LHCGR
5 growth/size/body region MP:0005378 9.87 NR5A1 PTHLH STAR CYP11A1 CYP19A1 ESR1
6 adipose tissue MP:0005375 9.76 CYP19A1 ESR1 LHCGR PTHLH
7 liver/biliary system MP:0005370 9.46 AFP CYP11A1 CYP19A1 ESR1
8 reproductive system MP:0005389 9.28 AFP CYP11A1 CYP17A1 CYP19A1 ESR1 LHCGR
9 renal/urinary system MP:0005367 9.26 CYP19A1 ESR1 LHCGR PTHLH

Drugs & Therapeutics for Leydig Cell Tumor

Drugs for Leydig Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Castor oil Approved, Vet_approved Phase 2, Phase 3
2
Methyltestosterone Approved Phase 2, Phase 3 58-18-4 6010
3
Testosterone Approved, Investigational Phase 2, Phase 3 58-22-0 6013
4 Anabolic Agents Phase 2, Phase 3
5 Androgens Phase 2, Phase 3
6 Antineoplastic Agents, Hormonal Phase 2, Phase 3
7 Cathartics Phase 2, Phase 3
8 Gastrointestinal Agents Phase 2, Phase 3
9 Hormone Antagonists Phase 2, Phase 3
10 Hormones Phase 2, Phase 3
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
12 Laxatives Phase 2, Phase 3
13 Testosterone 17 beta-cypionate Phase 2, Phase 3
14
Testosterone enanthate Phase 2, Phase 3 315-37-7 9416
15 Testosterone undecanoate Phase 2, Phase 3
16 Castor Nutraceutical Phase 2, Phase 3
17
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
18
Carboplatin Approved Phase 2,Phase 1 41575-94-4 10339178 498142 38904
19
Bleomycin Approved Phase 2 11056-06-7 5360373
20
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
21
Etoposide Approved Phase 2 33419-42-0 36462
22
Bevacizumab Approved, Investigational Phase 2 216974-75-3
23 Albumin-Bound Paclitaxel Phase 2
24 Antimitotic Agents Phase 2
25 Antineoplastic Agents, Phytogenic Phase 2
26 Anti-Bacterial Agents Phase 2
27 Antibiotics, Antitubercular Phase 2
28 Etoposide phosphate Phase 2
29 Topoisomerase Inhibitors Phase 2
30 Angiogenesis Inhibitors Phase 2
31 Angiogenesis Modulating Agents Phase 2
32 Antibodies Phase 2
33 Antibodies, Monoclonal Phase 2
34 Endothelial Growth Factors Phase 2
35 Immunoglobulins Phase 2
36 Mitogens Phase 2
37
Gemcitabine Approved Phase 1 95058-81-4 60750
38 Anti-Infective Agents Phase 1
39 Antimetabolites Phase 1
40 Antimetabolites, Antineoplastic Phase 1
41 Antiviral Agents Phase 1
42 Immunosuppressive Agents Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Androgen for Leydig Cell Proliferation Completed NCT01206270 Phase 2, Phase 3 Testosterone undecanoate;Castor Oil
2 Study of Testosterone vs Placebo in Testicular Cancer Survivors Recruiting NCT02991209 Phase 2, Phase 3 Testosterone;Placebos
3 Paclitaxel in Treating Patients With Ovarian Stromal Cancer Completed NCT00006227 Phase 2 Paclitaxel
4 Paclitaxel and Carboplatin or Bleomycin Sulfate, Etoposide Phosphate, and Cisplatin in Treating Patients With Advanced or Recurrent Sex Cord-Ovarian Stromal Tumors Recruiting NCT01042522 Phase 2 Carboplatin;Cisplatin;Etoposide Phosphate;Paclitaxel
5 Bevacizumab in Treating Patients With Recurrent Sex Cord-Stromal Tumors of the Ovary Active, not recruiting NCT00748657 Phase 2
6 Carboplatin, Gemcitabine Hydrochloride, and Stereotactic Body Radiation Therapy in Gynecological Cancer Completed NCT01652794 Phase 1 carboplatin;gemcitabine hydrochloride
7 Studying Genes in Samples From Younger Patients With Ovarian or Testicular Sex Cord Stromal Tumors Completed NCT01572467
8 Stress Reduction in Improving Quality of Life in Patients With Recurrent Gynecologic or Breast Cancer Completed NCT01764789
9 DICER1-related Pleuropulmonary Blastoma Cancer Predisposition Syndrome: A Natural History Study Recruiting NCT01247597
10 Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome Recruiting NCT00565903

Search NIH Clinical Center for Leydig Cell Tumor

Cochrane evidence based reviews: leydig cell tumor

Genetic Tests for Leydig Cell Tumor

Anatomical Context for Leydig Cell Tumor

MalaCards organs/tissues related to Leydig Cell Tumor:

39
Ovary, Testis, Breast, Endothelial, Lung, Prostate, Testes

Publications for Leydig Cell Tumor

Articles related to Leydig Cell Tumor:

(show top 50) (show all 380)
id Title Authors Year
1
Sertoli-Leydig Cell Tumor with Concurrent Rhabdomyosarcoma: Three Case Reports and a Review of the Literature. ( 28751916 )
2017
2
Leydig Cell Tumor of Testis in a Child: An Uncommon Presentation. ( 28694581 )
2017
3
DICER1 hotspot mutations in ovarian Sertoli-Leydig cell tumors: a potential association with androgenic effects. ( 27664536 )
2017
4
Leydig cell tumor in grey zone: A case report. ( 28419904 )
2017
5
An inguinal hernia with cryptorchidism with a Leydig cell tumor in an elderly man: A case report. ( 28171846 )
2017
6
A Case Report: Ovarian Sertoli-Leydig Cell Tumor With Hyperestrogenism and Endometrial Hyperplasia in a Postmenopausal Woman. ( 28469526 )
2017
7
Incidental Leydig Cell Tumor in Patient with Hormone Resistant Prostate Cancer. ( 28443242 )
2017
8
Leydig cell tumor in the post-menopausal woman: case report and literature review. ( 28112699 )
2017
9
Ovarian Sertoli-Leydig Cell Tumor with Elevated Inhibin B as a Cause of Secondary Amenorrhea in an Adolescent with Germ Line DICER1 Mutation. ( 28502826 )
2017
10
Leydig cell tumor in ovary of a German Shepherd bitch: An immunohistopathological study. ( 28473902 )
2017
11
Retiform Sertoli-Leydig Cell Tumor in a 38-Year-Old Woman: A Case Report, Retrospective Review, and Review of Current Literature. ( 28316852 )
2017
12
Recurrent ovarian Sertoli-Leydig cell tumor in a child with Peutz-Jeghers syndrome. ( 28101370 )
2016
13
Fertility-sparing management and obstetric outcomes in a 20-year-old patient with a Sertoli-Leydig cell tumor of the ovary: A case report and review of the literature. ( 27446397 )
2016
14
Recurrent Sertoli-Leydig cell tumor of ovary in 8-year-old girl. ( 27334531 )
2016
15
Leydig cell tumor found incidentally during microscopic testicular sperm extraction in patient with mosaic Klinefelter syndrome: case report. ( 27523297 )
2016
16
The co-occurrence of an ovarian Sertoli-Leydig cell tumor with a thyroid carcinoma is highly suggestive of a DICER1 syndrome. ( 26983701 )
2016
17
Sertoli - Leydig cell tumor with retiform areas and overgrowth of rhabdomyosarcomatous elements: case report and literature review. ( 27473538 )
2016
18
Atypical Leydig Cell Tumor in Children: Report of 2 Cases. ( 27940757 )
2016
19
Sertoli-Leydig cell tumor of the ovary: A diagnostic dilemma. ( 26937481 )
2016
20
A Rare Case of Intra-Endometrial Leiomyoma of Uterus Simulating Degenerated Submucosal Leiomyoma Accompanied by a Large Sertoli-Leydig Cell Tumor. ( 26847310 )
2016
21
Leydig cell tumor of the testis with azoospermia and elevated delta4 androstenedione: case report. ( 27833751 )
2016
22
Large moderately-differentiated ovarian Sertoli-Leydig cell tumor in a 13-year-old female: A case report. ( 26893701 )
2016
23
Ovarian Sertoli-Leydig cell tumor with heterologous elements containing an unusual type of alpha-fetoprotein-producing cells. ( 27126717 )
2016
24
Testicular Leydig Cell Tumor with Metachronous Lesions: Outcomes after Metastasis Resection and Cryoablation. ( 26525589 )
2015
25
Leydig cell tumor incidentally detected by fused FDG-PET/MRI. ( 25636443 )
2015
26
Cervical embryonal rhabdomyosarcoma and ovarian Sertoli-Leydig cell tumor with congenital absence of unilateral ovary. ( 26458643 )
2015
27
The oncogenic roles of DICER1 RNase IIIb domain mutations in ovarian Sertoli-Leydig cell tumors. ( 26408257 )
2015
28
Alopecia and Hirsutism in a Postmenopausal Woman as the Presenting Complaint of Ovarian Hilus (Leydig) Cell Tumor. ( 25910403 )
2015
29
Leydig cell tumor in a patient with 49,XXXXY karyotype: a review of literature. ( 26160035 )
2015
30
Metastasized Leydig cell tumor in a dog. ( 26753337 )
2015
31
Ovarian Sertoli-Leydig Cell Tumor with Predominant Heterologous Mucinous Differentiation and Foci of Hepatocytic Differentiation: Case Report and Review of The Literature. ( 26116602 )
2015
32
Leydig cell tumor of testis with indeterminate features. ( 26960466 )
2015
33
True Precocious Puberty Following Treatment of a Leydig Cell Tumor: Two Case Reports and Literature Review. ( 26579503 )
2015
34
Leydig cell tumor with lung metastasis diagnosed by lung biopsy. ( 26722493 )
2015
35
Sertoli-Leydig cell tumor in a 12-year-old girl: a review article and case report. ( 25027813 )
2014
36
Ovarian Leydig cell tumor in a post-menopausal patient with severe hyperandrogenism. ( 24728167 )
2014
37
Testicular adrenal rest tumor mimicking leydig cell tumor in a patient with congenital adrenal hyperplasia. ( 24834391 )
2014
38
Bilateral sertoli-leydig cell tumor in a primigravida: a rare case. ( 25002956 )
2014
39
Metastatic relapse after initial clinical stage I testicular Leydig cell tumor. ( 24855728 )
2014
40
Ovarian Sertoli-Leydig cell tumor with heterologous elements of gastrointestinal type associated with elevated serum alpha-fetoprotein level: an unusual case and literature review. ( 25926909 )
2014
41
Sertoli-Leydig cell tumor with unique nail findings in a post-menopausal woman: a case report and literature review. ( 25296983 )
2014
42
A leydig cell tumor of the ovary resulting in extreme hyperandrogenism, erythrocytosis, and recurrent pulmonary embolism. ( 24152686 )
2014
43
A novel DICER1 mutation identified in a female with ovarian Sertoli-Leydig cell tumor and multinodular goiter: a case report. ( 24708902 )
2014
44
Sertoli-Leydig cell tumor with heterologous element: a case report and a review of the literature. ( 24696734 )
2014
45
Bilateral laparoscopic gonadectomy in a patient with complete androgen insensitivity syndrome and bilateral sertoli-leydig cell tumor: a case report and brief review of the literature. ( 25032133 )
2014
46
Sertoli-leydig cell tumor of ovary- a diagnostic dilemma. ( 24783104 )
2014
47
Woman with virilizing congenital adrenal hyperplasia and Leydig cell tumor of the ovary. ( 24702195 )
2014
48
Sertoli-Leydig cell tumors: hormonal profile after dynamic test with GnRH analogue: triptorelin represents a useful tool to evaluate tumoral hyperandrogenism. ( 25299229 )
2014
49
Atypical leydig cell tumor in a young child. ( 24040603 )
2013
50
Complete Androgen Insensitivity Syndrome with a Sertoli-Leydig Cell Tumor. ( 24333107 )
2013

Variations for Leydig Cell Tumor

Expression for Leydig Cell Tumor

Search GEO for disease gene expression data for Leydig Cell Tumor.

Pathways for Leydig Cell Tumor

GO Terms for Leydig Cell Tumor

Biological processes related to Leydig Cell Tumor according to GeneCards Suite gene sharing:

(show all 19)
id Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.88 CYP11A1 CYP17A1 CYP19A1 CYP21A2
2 steroid metabolic process GO:0008202 9.69 CYP11A1 CYP17A1 CYP21A2
3 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.58 LHCGR PTHLH
4 intracellular receptor signaling pathway GO:0030522 9.57 ESR1 NR5A1
5 hormone-mediated signaling pathway GO:0009755 9.56 LHCGR NR5A1
6 female gonad development GO:0008585 9.55 CYP19A1 NR5A1
7 androgen metabolic process GO:0008209 9.54 CYP19A1 ESR1
8 uterus development GO:0060065 9.52 CYP19A1 ESR1
9 estrogen biosynthetic process GO:0006703 9.49 CYP19A1 STAR
10 C21-steroid hormone biosynthetic process GO:0006700 9.48 CYP11A1 STAR
11 progesterone metabolic process GO:0042448 9.46 AFP CYP17A1
12 male gonad development GO:0008584 9.46 ESR1 LHCGR NR5A1 STAR
13 cellular response to gonadotropin stimulus GO:0071371 9.43 LHCGR STAR
14 regulation of steroid biosynthetic process GO:0050810 9.4 NR5A1 STAR
15 glucocorticoid biosynthetic process GO:0006704 9.37 CYP17A1 CYP21A2
16 testosterone biosynthetic process GO:0061370 9.32 CYP19A1 STAR
17 cellular response to luteinizing hormone stimulus GO:0071373 9.26 LHCGR STAR
18 sterol metabolic process GO:0016125 9.26 CYP11A1 CYP17A1 CYP19A1 CYP21A2
19 steroid biosynthetic process GO:0006694 9.02 CYP11A1 CYP17A1 CYP19A1 CYP21A2 STAR

Molecular functions related to Leydig Cell Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.71 CYP11A1 CYP17A1 CYP19A1 CYP21A2
2 lipid binding GO:0008289 9.56 CYP21A2 ESR1 NR5A1 STAR
3 oxygen binding GO:0019825 9.46 CYP17A1 CYP19A1
4 iron ion binding GO:0005506 9.46 CYP11A1 CYP17A1 CYP19A1 CYP21A2
5 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0004879 9.43 ESR1 NR5A1
6 steroid binding GO:0005496 9.37 CYP21A2 ESR1
7 steroid hydroxylase activity GO:0008395 9.32 CYP19A1 CYP21A2
8 heme binding GO:0020037 9.26 CYP11A1 CYP17A1 CYP19A1 CYP21A2
9 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 8.92 CYP11A1 CYP17A1 CYP19A1 CYP21A2
10 metal ion binding GO:0046872 10.02 AFP CYP11A1 CYP17A1 CYP19A1 CYP21A2 ESR1

Sources for Leydig Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
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70 UMLS via Orphanet
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