MCID: LCH014
MIFTS: 29

Lichen Amyloidosis malady

Categories: Skin diseases, Rare diseases

Aliases & Classifications for Lichen Amyloidosis

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Sources:
31ICD10 via Orphanet, 54Orphanet, 68UMLS
See all MalaCards sources

Aliases & Descriptions for Lichen Amyloidosis:

Name: Lichen Amyloidosis 54
Amyloidosis, Primary Cutaneous 68
 
Lichen Amyloidosus 54
Amyloid Lichen 54

Classifications:

Orphanet: 54 
Rare skin diseases


External Ids:

Orphanet54 ORPHA49804
ICD10 via Orphanet31 E85.4+, L99.0*

Summaries for Lichen Amyloidosis

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MalaCards based summary: Lichen Amyloidosis, also known as amyloidosis, primary cutaneous, is related to amyloidosis, primary localized cutaneous, 1 and primary cutaneous amyloidosis, and has symptoms including Array, Array and pruritus. An important gene associated with Lichen Amyloidosis is RET (Ret Proto-Oncogene), and among its related pathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include skin and thyroid.

Related Diseases for Lichen Amyloidosis

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Graphical network of the top 20 diseases related to Lichen Amyloidosis:



Diseases related to lichen amyloidosis

Symptoms & Phenotypes for Lichen Amyloidosis

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Human phenotypes related to Lichen Amyloidosis:

 54 64
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 pruritus64 54 Very frequent (99-80%) HP:0000989
2 papule64 54 Very frequent (99-80%) HP:0200034

Drugs & Therapeutics for Lichen Amyloidosis

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Drugs for Lichen Amyloidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Methylene blueinvestigational8961-73-4
Synonyms:
Basic Blue 9
C.I. basic blue 9
Lowacryl blue 9
Methylene blue
Methylene blue anhydrous
Methylthioninium chloride
 
Urolene Blue
aniline violet
methylenium ceruleum
methylthionine chloride
methylthioninium chloride
methylthioninium chloride Proveblue
tetrametylthionine chloride
2Pharmaceutical Solutions8192

Interventional clinical trials:

idNameStatusNCT IDPhase
1Efficacy of 308-nm Excimer Laser for Primary Localized Cutaneous Amyloidosis Treatment in AsiansRecruitingNCT03068156
2Efficacy of Methylene Blue Mediated Photodynamic Therapy for Primary Localized Cutaneous Amyloidosis Treatment in AsiansNot yet recruitingNCT03068208

Search NIH Clinical Center for Lichen Amyloidosis

Genetic Tests for Lichen Amyloidosis

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Anatomical Context for Lichen Amyloidosis

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MalaCards organs/tissues related to Lichen Amyloidosis:

36
Skin, Thyroid

Publications for Lichen Amyloidosis

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Articles related to Lichen Amyloidosis:

(show top 50)    (show all 55)
idTitleAuthorsYear
1
Successful treatment of lichen amyloidosis accompanied by atopic dermatitis by fractional CO2 laser. (28535110)
2017
2
Lichen amyloidosis associated with rheumatoid arthritis: unique presentation in a Bulgarian patient. (28076615)
2017
3
Cutaneous lichen amyloidosis in multiple endocrine neoplasia. (26813904)
2016
4
Ripple-pattern lichen amyloidosis in a case of ichthyosis vulgaris with a novel FLG mutation. (27530091)
2016
5
MEN 2A-related cutaneous lichen amyloidosis: report of three kindred and systematic literature review of clinical, biochemical and molecular characteristics. (26920351)
2016
6
Image Gallery: Lichen amyloidosis on the external auditory canal. (27996148)
2016
7
Oral isotretinoin: A new treatment alternative for generalized lichen amyloidosis. (27469487)
2016
8
Vesicular lesions in lichen amyloidosis. (26374661)
2015
9
Vesicular lesions in lichen amyloidosis. (26515863)
2015
10
THE AUTOIMMUNE CONSTELLATION IN LICHEN AMYLOIDOSIS. (26793847)
2015
11
Bullous variant of familial biphasic lichen amyloidosis: a unique combination of three rare presentations. (25657431)
2015
12
Successful treatment of lichen amyloidosis using capsaicin 8% patch. (25904403)
2015
13
Fractional 1,550nm Ytterbium/Erbium fiber laser in the treatment of lichen amyloidosis: Clinical and histological study. (25771782)
2015
14
Rare manifestation of multiple endocrine neoplasia type 2A & cutaneous lichen amyloidosis in a family with RET gene mutation. (25027091)
2014
15
Response to oral acitretin in lichen amyloidosis. (25593815)
2014
16
Successful treatment of lichen amyloidosis using a CO2 surgical laser. (24703261)
2014
17
Bullous pemphigoid clinically presenting as lichen amyloidosis. (25382517)
2014
18
A Th2 Cytokine Interleukin 31 Signature in a Case of Sporadic Lichen Amyloidosis. (24573820)
2014
19
Itch in familial lichen amyloidosis: effective treatment with amitriptyline in two cases. (24502303)
2014
20
Satisfactory response to narrowband UV-B therapy in generalized lichen amyloidosis. (23084256)
2013
21
Lichen amyloidosis. (24130236)
2013
22
Primary cutaneous lichen amyloidosis of the external auditory canal, possibly due to scratching with a metal nail head for severe pruritus. (24201228)
2013
23
Asymptomatic conchal papules. Lichen amyloidosis of the auricular concha. (23619461)
2013
24
Generalized lichen amyloidosis and hyperthyroidism: coincidence or association. (24278086)
2013
25
A generalized, non-pruritic variant of lichen amyloidosis: a case report and a brief review. (23919033)
2013
26
Lichen Amyloidosis: Novel Treatment with Fractional Ablative 2,940 nm Erbium: YAG Laser Treatment. (23060710)
2012
27
'Shiny white streaks' in lichen amyloidosis: a clue to diagnosis. (23157777)
2012
28
Dermacase. Can you identify this condition? Lichen amyloidosis. (23152462)
2012
29
Lichen amyloidosis in a dark skinned patient. (20197753)
2010
30
Lichen amyloidosis of the auricular concha: successful treatment with electrodesiccation. (19284460)
2009
31
A case of atopic dermatitis-associated lichen amyloidosis successfully treated with oral cyclosporine and narrow band UVB therapy in succession. (19954395)
2009
32
Familial medullary thyroid carcinoma associated with cutaneous lichen amyloidosis. (19445625)
2009
33
A case of membranous lipodystrophy observed in lichen amyloidosis. (20523780)
2009
34
Successful treatment of therapy-resistant pruritus in lichen amyloidosis with menthol. (19734984)
2009
35
Pruritic patches on the back and papules on the legs. Primary localized cutaneous amyloidosis (PLCA) (cutaneous lichen amyloidosis and macular amyloidosis). (17310008)
2007
36
Multiple endocrine neoplasia type 2A/localized cutaneous lichen amyloidosis associated with malignant pheochromocytoma and ganglioneuroma. (16277170)
2005
37
Frequent association between MEN 2A and cutaneous lichen amyloidosis. (12864791)
2003
38
Visual vignette. Multiple endocrine neoplasia type 2A (MEN2A) associated with cutaneous lichen amyloidosis. (14758805)
2003
39
Early onset of medullary thyroid carcinoma in a kindred with multiple endocrine neoplasia type iia associated with cutaneous lichen amyloidosis. (11939755)
2002
40
Cutaneous lichen amyloidosis in multiple endocrine neoplasia type 2A. (12593731)
2002
41
Lichen amyloidosis, ankylosing spondylitis and autoimmune thyroiditis: coincidence or association? (10972101)
2000
42
Treatment of lichen amyloidosis (LA) and disseminated superficial porokeratosis (DSP) with frequency-doubled Q-switched Nd:YAG laser. (11050503)
2000
43
A Cys634Gly substitution of the RET proto-oncogene in a family with recurrence of multiple endocrine neoplasia type 2A and cutaneous lichen amyloidosis. (9111993)
1997
44
RET mutation screening in familial cutaneous lichen amyloidosis and in skin amyloidosis associated with multiple endocrine neoplasia. (8757765)
1996
45
Identification of the Cys634-->Tyr mutation of the RET proto-oncogene in a pedigree with multiple endocrine neoplasia type 2A and localized cutaneous lichen amyloidosis. (7914213)
1994
46
Clinicopathologic and immunohistochemical studies on lichen amyloidosis and macular amyloidosis. (7527208)
1994
47
Multiple endocrine neoplasia type 2A and cutaneous lichen amyloidosis: description of a new family. (8099921)
1993
48
Cutaneous lesion associated with multiple endocrine neoplasia type 2A: lichen amyloidosis or notalgia paresthetica? (1362414)
1992
49
Sipple syndrome with lichen amyloidosis as a paracrinopathy. (1352941)
1992
50
Lichen amyloidosis in Alagille syndrome. (1929477)
1991

Variations for Lichen Amyloidosis

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Expression for genes affiliated with Lichen Amyloidosis

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Search GEO for disease gene expression data for Lichen Amyloidosis.

Pathways for genes affiliated with Lichen Amyloidosis

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Pathways related to Lichen Amyloidosis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
8.0IL31, IL31RA, OSMR, RET
2
Show member pathways
8.0IL31, IL31RA, OSMR, RET

GO Terms for genes affiliated with Lichen Amyloidosis

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Cellular components related to Lichen Amyloidosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1axonGO:00304249.4IL31RA, RET

Biological processes related to Lichen Amyloidosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MAPK cascadeGO:000016510.0IL31RA, RET
2transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071699.4IL31RA, RET

Molecular functions related to Lichen Amyloidosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine receptor activityGO:00048969.1IL31RA, OSMR

Sources for Lichen Amyloidosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet