MCID: LCH014
MIFTS: 33

Lichen Amyloidosis

Categories: Skin diseases, Rare diseases

Aliases & Classifications for Lichen Amyloidosis

MalaCards integrated aliases for Lichen Amyloidosis:

Name: Lichen Amyloidosis 55
Amyloidosis, Primary Cutaneous 69
Lichen Amyloidosus 55
Amyloid Lichen 55

Classifications:

Orphanet: 55  
Rare skin diseases


External Ids:

Orphanet 55 ORPHA49804
ICD10 via Orphanet 33 L99.0* E85.4+
UMLS 69 C0268397

Summaries for Lichen Amyloidosis

MalaCards based summary : Lichen Amyloidosis, also known as amyloidosis, primary cutaneous, is related to primary cutaneous amyloidosis and amyloidosis, and has symptoms including pruritus and papule. An important gene associated with Lichen Amyloidosis is IL31RA (Interleukin 31 Receptor A), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Methylene blue and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include skin and thyroid.

Related Diseases for Lichen Amyloidosis

Graphical network of the top 20 diseases related to Lichen Amyloidosis:



Diseases related to Lichen Amyloidosis

Symptoms & Phenotypes for Lichen Amyloidosis

Human phenotypes related to Lichen Amyloidosis:

55 31
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 pruritus 55 31 hallmark (90%) Very frequent (99-80%) HP:0000989
2 papule 55 31 hallmark (90%) Very frequent (99-80%) HP:0200034

Drugs & Therapeutics for Lichen Amyloidosis

Drugs for Lichen Amyloidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylene blue Approved, Investigational 61-73-4
2 Pharmaceutical Solutions

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy of 308-nm Excimer Laser for Primary Localized Cutaneous Amyloidosis Treatment in Asians Recruiting NCT03068156
2 Efficacy of Methylene Blue Mediated Photodynamic Therapy for Primary Localized Cutaneous Amyloidosis Treatment in Asians Not yet recruiting NCT03068208

Search NIH Clinical Center for Lichen Amyloidosis

Genetic Tests for Lichen Amyloidosis

Anatomical Context for Lichen Amyloidosis

MalaCards organs/tissues related to Lichen Amyloidosis:

38
Skin, Thyroid

Publications for Lichen Amyloidosis

Articles related to Lichen Amyloidosis:

(show top 50) (show all 61)
# Title Authors Year
1
Lichen amyloidosis successfully treated with fractional ablative laser CO<sub>2</sub>: A new alternative therapeutic. ( 29400590 )
2018
2
The Clinical Spectrum of Multiple Endocrine Neoplasia Type 2A with Cutaneous Lichen Amyloidosis in Ethnic Han Chinese. ( 29420094 )
2018
3
Alitretinoin treatment of lichen amyloidosis. ( 28906049 )
2017
4
Successful treatment of lichen amyloidosis accompanied by atopic dermatitis by fractional CO2 laser. ( 28535110 )
2017
5
Lichen amyloidosis of the scalp and forehead. ( 29447646 )
2017
6
Lichen amyloidosis associated with rheumatoid arthritis: unique presentation in a Bulgarian patient. ( 28076615 )
2017
7
Increase in sensory sensitivity around, but not in the central part of, the hyperkeratotic papule in lichen amyloidosis. ( 28334422 )
2017
8
Lichen amyloidosis involving the scalp. ( 28744954 )
2017
9
MEN 2A-related cutaneous lichen amyloidosis: report of three kindred and systematic literature review of clinical, biochemical and molecular characteristics. ( 26920351 )
2016
10
Oral isotretinoin: A new treatment alternative for generalized lichen amyloidosis. ( 27469487 )
2016
11
Cutaneous lichen amyloidosis in multiple endocrine neoplasia. ( 26813904 )
2016
12
Ripple-pattern lichen amyloidosis in a case of ichthyosis vulgaris with a novel FLG mutation. ( 27530091 )
2016
13
Image Gallery: Lichen amyloidosis on the external auditory canal. ( 27996148 )
2016
14
Vesicular lesions in lichen amyloidosis. ( 26515863 )
2015
15
Fractional 1,550nm Ytterbium/Erbium fiber laser in the treatment of lichen amyloidosis: Clinical and histological study. ( 25771782 )
2015
16
Successful treatment of lichen amyloidosis using capsaicin 8% patch. ( 25904403 )
2015
17
Bullous variant of familial biphasic lichen amyloidosis: a unique combination of three rare presentations. ( 25657431 )
2015
18
Vesicular lesions in lichen amyloidosis. ( 26374661 )
2015
19
THE AUTOIMMUNE CONSTELLATION IN LICHEN AMYLOIDOSIS. ( 26793847 )
2015
20
Itch in familial lichen amyloidosis: effective treatment with amitriptyline in two cases. ( 24502303 )
2014
21
Rare manifestation of multiple endocrine neoplasia type 2A & cutaneous lichen amyloidosis in a family with RET gene mutation. ( 25027091 )
2014
22
Successful treatment of lichen amyloidosis using a CO2 surgical laser. ( 24703261 )
2014
23
Response to oral acitretin in lichen amyloidosis. ( 25593815 )
2014
24
A Th2 Cytokine Interleukin 31 Signature in a Case of Sporadic Lichen Amyloidosis. ( 24573820 )
2014
25
Bullous pemphigoid clinically presenting as lichen amyloidosis. ( 25382517 )
2014
26
Primary cutaneous lichen amyloidosis of the external auditory canal, possibly due to scratching with a metal nail head for severe pruritus. ( 24201228 )
2013
27
Satisfactory response to narrowband UV-B therapy in generalized lichen amyloidosis. ( 23084256 )
2013
28
Lichen amyloidosis. ( 24130236 )
2013
29
Generalized lichen amyloidosis and hyperthyroidism: coincidence or association. ( 24278086 )
2013
30
A generalized, non-pruritic variant of lichen amyloidosis: a case report and a brief review. ( 23919033 )
2013
31
Asymptomatic conchal papules. Lichen amyloidosis of the auricular concha. ( 23619461 )
2013
32
Lichen Amyloidosis: Novel Treatment with Fractional Ablative 2,940 nm Erbium: YAG Laser Treatment. ( 23060710 )
2012
33
'Shiny white streaks' in lichen amyloidosis: a clue to diagnosis. ( 23157777 )
2012
34
Dermacase. Can you identify this condition? Lichen amyloidosis. ( 23152462 )
2012
35
Lichen amyloidosis in a dark skinned patient. ( 20197753 )
2010
36
Lichen amyloidosis of the auricular concha: successful treatment with electrodesiccation. ( 19284460 )
2009
37
A case of atopic dermatitis-associated lichen amyloidosis successfully treated with oral cyclosporine and narrow band UVB therapy in succession. ( 19954395 )
2009
38
A case of membranous lipodystrophy observed in lichen amyloidosis. ( 20523780 )
2009
39
Familial medullary thyroid carcinoma associated with cutaneous lichen amyloidosis. ( 19445625 )
2009
40
Successful treatment of therapy-resistant pruritus in lichen amyloidosis with menthol. ( 19734984 )
2009
41
Pruritic patches on the back and papules on the legs. Primary localized cutaneous amyloidosis (PLCA) (cutaneous lichen amyloidosis and macular amyloidosis). ( 17310008 )
2007
42
Multiple endocrine neoplasia type 2A/localized cutaneous lichen amyloidosis associated with malignant pheochromocytoma and ganglioneuroma. ( 16277170 )
2005
43
Frequent association between MEN 2A and cutaneous lichen amyloidosis. ( 12864791 )
2003
44
Visual vignette. Multiple endocrine neoplasia type 2A (MEN2A) associated with cutaneous lichen amyloidosis. ( 14758805 )
2003
45
Early onset of medullary thyroid carcinoma in a kindred with multiple endocrine neoplasia type iia associated with cutaneous lichen amyloidosis. ( 11939755 )
2002
46
Cutaneous lichen amyloidosis in multiple endocrine neoplasia type 2A. ( 12593731 )
2002
47
Treatment of lichen amyloidosis (LA) and disseminated superficial porokeratosis (DSP) with frequency-doubled Q-switched Nd:YAG laser. ( 11050503 )
2000
48
Lichen amyloidosis, ankylosing spondylitis and autoimmune thyroiditis: coincidence or association? ( 10972101 )
2000
49
A Cys634Gly substitution of the RET proto-oncogene in a family with recurrence of multiple endocrine neoplasia type 2A and cutaneous lichen amyloidosis. ( 9111993 )
1997
50
RET mutation screening in familial cutaneous lichen amyloidosis and in skin amyloidosis associated with multiple endocrine neoplasia. ( 8757765 )
1996

Variations for Lichen Amyloidosis

Expression for Lichen Amyloidosis

Search GEO for disease gene expression data for Lichen Amyloidosis.

Pathways for Lichen Amyloidosis

Pathways related to Lichen Amyloidosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.85 IL31 IL31RA OSMR RET
2
Show member pathways
12.03 IL31 IL31RA OSMR RET

GO Terms for Lichen Amyloidosis

Cellular components related to Lichen Amyloidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 8.62 IL31RA RET

Biological processes related to Lichen Amyloidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 8.96 IL31RA RET
2 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 8.62 IL31RA RET

Molecular functions related to Lichen Amyloidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine receptor activity GO:0004896 8.62 IL31RA OSMR

Sources for Lichen Amyloidosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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