MCID: LCH014
MIFTS: 30

Lichen Amyloidosis

Categories: Skin diseases, Rare diseases

Aliases & Classifications for Lichen Amyloidosis

MalaCards integrated aliases for Lichen Amyloidosis:

Name: Lichen Amyloidosis 56
Amyloidosis, Primary Cutaneous 69
Lichen Amyloidosus 56
Amyloid Lichen 56

Classifications:

Orphanet: 56  
Rare skin diseases


External Ids:

Orphanet 56 ORPHA49804
ICD10 via Orphanet 34 L99.0* E85.4+

Summaries for Lichen Amyloidosis

MalaCards based summary : Lichen Amyloidosis, also known as amyloidosis, primary cutaneous, is related to amyloidosis, primary localized cutaneous, 1 and primary cutaneous amyloidosis, and has symptoms including pruritus and papule. An important gene associated with Lichen Amyloidosis is IL31RA (Interleukin 31 Receptor A), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Methylene blue and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include skin and thyroid.

Related Diseases for Lichen Amyloidosis

Graphical network of the top 20 diseases related to Lichen Amyloidosis:



Diseases related to Lichen Amyloidosis

Symptoms & Phenotypes for Lichen Amyloidosis

Human phenotypes related to Lichen Amyloidosis:

56 32
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 pruritus 56 32 hallmark (90%) Very frequent (99-80%) HP:0000989
2 papule 56 32 hallmark (90%) Very frequent (99-80%) HP:0200034

Drugs & Therapeutics for Lichen Amyloidosis

Drugs for Lichen Amyloidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylene blue Investigational 61-73-4
2 Pharmaceutical Solutions

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Efficacy of 308-nm Excimer Laser for Primary Localized Cutaneous Amyloidosis Treatment in Asians Recruiting NCT03068156
2 Efficacy of Methylene Blue Mediated Photodynamic Therapy for Primary Localized Cutaneous Amyloidosis Treatment in Asians Not yet recruiting NCT03068208

Search NIH Clinical Center for Lichen Amyloidosis

Genetic Tests for Lichen Amyloidosis

Anatomical Context for Lichen Amyloidosis

MalaCards organs/tissues related to Lichen Amyloidosis:

39
Skin, Thyroid

Publications for Lichen Amyloidosis

Articles related to Lichen Amyloidosis:

(show top 50) (show all 58)
id Title Authors Year
1
Alitretinoin treatment of lichen amyloidosis. ( 28906049 )
2017
2
Lichen amyloidosis involving the scalp. ( 28744954 )
2017
3
Lichen amyloidosis associated with rheumatoid arthritis: unique presentation in a Bulgarian patient. ( 28076615 )
2017
4
Successful treatment of lichen amyloidosis accompanied by atopic dermatitis by fractional CO2 laser. ( 28535110 )
2017
5
Increase in sensory sensitivity around, but not in the central part of, the hyperkeratotic papule in lichen amyloidosis. ( 28334422 )
2017
6
Ripple-pattern lichen amyloidosis in a case of ichthyosis vulgaris with a novel FLG mutation. ( 27530091 )
2016
7
Cutaneous lichen amyloidosis in multiple endocrine neoplasia. ( 26813904 )
2016
8
Oral isotretinoin: A new treatment alternative for generalized lichen amyloidosis. ( 27469487 )
2016
9
Image Gallery: Lichen amyloidosis on the external auditory canal. ( 27996148 )
2016
10
MEN 2A-related cutaneous lichen amyloidosis: report of three kindred and systematic literature review of clinical, biochemical and molecular characteristics. ( 26920351 )
2016
11
Bullous variant of familial biphasic lichen amyloidosis: a unique combination of three rare presentations. ( 25657431 )
2015
12
Fractional 1,550nm Ytterbium/Erbium fiber laser in the treatment of lichen amyloidosis: Clinical and histological study. ( 25771782 )
2015
13
Vesicular lesions in lichen amyloidosis. ( 26374661 )
2015
14
Vesicular lesions in lichen amyloidosis. ( 26515863 )
2015
15
THE AUTOIMMUNE CONSTELLATION IN LICHEN AMYLOIDOSIS. ( 26793847 )
2015
16
Successful treatment of lichen amyloidosis using capsaicin 8% patch. ( 25904403 )
2015
17
Bullous pemphigoid clinically presenting as lichen amyloidosis. ( 25382517 )
2014
18
A Th2 Cytokine Interleukin 31 Signature in a Case of Sporadic Lichen Amyloidosis. ( 24573820 )
2014
19
Itch in familial lichen amyloidosis: effective treatment with amitriptyline in two cases. ( 24502303 )
2014
20
Rare manifestation of multiple endocrine neoplasia type 2A & cutaneous lichen amyloidosis in a family with RET gene mutation. ( 25027091 )
2014
21
Successful treatment of lichen amyloidosis using a CO2 surgical laser. ( 24703261 )
2014
22
Response to oral acitretin in lichen amyloidosis. ( 25593815 )
2014
23
Satisfactory response to narrowband UV-B therapy in generalized lichen amyloidosis. ( 23084256 )
2013
24
A generalized, non-pruritic variant of lichen amyloidosis: a case report and a brief review. ( 23919033 )
2013
25
Primary cutaneous lichen amyloidosis of the external auditory canal, possibly due to scratching with a metal nail head for severe pruritus. ( 24201228 )
2013
26
Asymptomatic conchal papules. Lichen amyloidosis of the auricular concha. ( 23619461 )
2013
27
Lichen amyloidosis. ( 24130236 )
2013
28
Generalized lichen amyloidosis and hyperthyroidism: coincidence or association. ( 24278086 )
2013
29
Dermacase. Can you identify this condition? Lichen amyloidosis. ( 23152462 )
2012
30
Lichen Amyloidosis: Novel Treatment with Fractional Ablative 2,940 nm Erbium: YAG Laser Treatment. ( 23060710 )
2012
31
'Shiny white streaks' in lichen amyloidosis: a clue to diagnosis. ( 23157777 )
2012
32
Lichen amyloidosis in a dark skinned patient. ( 20197753 )
2010
33
Familial medullary thyroid carcinoma associated with cutaneous lichen amyloidosis. ( 19445625 )
2009
34
Lichen amyloidosis of the auricular concha: successful treatment with electrodesiccation. ( 19284460 )
2009
35
A case of membranous lipodystrophy observed in lichen amyloidosis. ( 20523780 )
2009
36
Successful treatment of therapy-resistant pruritus in lichen amyloidosis with menthol. ( 19734984 )
2009
37
A case of atopic dermatitis-associated lichen amyloidosis successfully treated with oral cyclosporine and narrow band UVB therapy in succession. ( 19954395 )
2009
38
Pruritic patches on the back and papules on the legs. Primary localized cutaneous amyloidosis (PLCA) (cutaneous lichen amyloidosis and macular amyloidosis). ( 17310008 )
2007
39
Multiple endocrine neoplasia type 2A/localized cutaneous lichen amyloidosis associated with malignant pheochromocytoma and ganglioneuroma. ( 16277170 )
2005
40
Frequent association between MEN 2A and cutaneous lichen amyloidosis. ( 12864791 )
2003
41
Visual vignette. Multiple endocrine neoplasia type 2A (MEN2A) associated with cutaneous lichen amyloidosis. ( 14758805 )
2003
42
Early onset of medullary thyroid carcinoma in a kindred with multiple endocrine neoplasia type iia associated with cutaneous lichen amyloidosis. ( 11939755 )
2002
43
Cutaneous lichen amyloidosis in multiple endocrine neoplasia type 2A. ( 12593731 )
2002
44
Treatment of lichen amyloidosis (LA) and disseminated superficial porokeratosis (DSP) with frequency-doubled Q-switched Nd:YAG laser. ( 11050503 )
2000
45
Lichen amyloidosis, ankylosing spondylitis and autoimmune thyroiditis: coincidence or association? ( 10972101 )
2000
46
A Cys634Gly substitution of the RET proto-oncogene in a family with recurrence of multiple endocrine neoplasia type 2A and cutaneous lichen amyloidosis. ( 9111993 )
1997
47
RET mutation screening in familial cutaneous lichen amyloidosis and in skin amyloidosis associated with multiple endocrine neoplasia. ( 8757765 )
1996
48
Identification of the Cys634-->Tyr mutation of the RET proto-oncogene in a pedigree with multiple endocrine neoplasia type 2A and localized cutaneous lichen amyloidosis. ( 7914213 )
1994
49
Clinicopathologic and immunohistochemical studies on lichen amyloidosis and macular amyloidosis. ( 7527208 )
1994
50
Multiple endocrine neoplasia type 2A and cutaneous lichen amyloidosis: description of a new family. ( 8099921 )
1993

Variations for Lichen Amyloidosis

Expression for Lichen Amyloidosis

Search GEO for disease gene expression data for Lichen Amyloidosis.

Pathways for Lichen Amyloidosis

Pathways related to Lichen Amyloidosis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.85 IL31 IL31RA OSMR RET
2
Show member pathways
12.03 IL31 IL31RA OSMR RET

GO Terms for Lichen Amyloidosis

Cellular components related to Lichen Amyloidosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 8.62 IL31RA RET

Biological processes related to Lichen Amyloidosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 8.96 IL31RA RET
2 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 8.62 IL31RA RET

Molecular functions related to Lichen Amyloidosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine receptor activity GO:0004896 8.62 IL31RA OSMR

Sources for Lichen Amyloidosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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