MCID: LCH002
MIFTS: 58

Lichen Planus

Categories: Skin diseases, Rare diseases, Genetic diseases

Aliases & Classifications for Lichen Planus

MalaCards integrated aliases for Lichen Planus:

Name: Lichen Planus 12 72 36 51 41 14 69
Lichen, Ruber Planus 12
Lichen Ruber Planus 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9201
ICD10 32 L43 L43.9
ICD9CM 34 697.0
MeSH 41 D008010
NCIt 46 C3189
KEGG 36 H01654
UMLS 69 C0023646

Summaries for Lichen Planus

Disease Ontology : 12 A lichen disease that is located in skin, located in tongue or located in oral mucosa, which presents itself in the form of papules, lesions or rashes.

MalaCards based summary : Lichen Planus, also known as lichen, ruber planus, is related to lichen planus pemphigoides and lichen sclerosus, and has symptoms including pruritus An important gene associated with Lichen Planus is COL17A1 (Collagen Type XVII Alpha 1 Chain), and among its related pathways/superpathways are Allograft rejection and Influenza A. The drugs Tacrolimus and Betamethasone have been mentioned in the context of this disorder. Affiliated tissues include skin, tongue or and skin, and related phenotypes are Increased gamma-H2AX phosphorylation and digestive/alimentary

Wikipedia : 72 Lichen planus (LP) is a disease characterized by itchy reddish-purple polygon-shaped skin lesions on the... more...

Related Diseases for Lichen Planus

Diseases in the Lichen Planus family:

Lichen Planus, Familial Rare Lichen Planus

Diseases related to Lichen Planus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 348)
# Related Disease Score Top Affiliating Genes
1 lichen planus pemphigoides 34.9 COL17A1 DST
2 lichen sclerosus 31.4 GZMB TNF TP53
3 gingivitis 31.2 DEFB4A IL4 TNF
4 graft-versus-host disease 30.8 GZMB IFNG TNF
5 pemphigus 30.8 COL17A1 DSG3 DST
6 periodontitis 30.8 IFNG IL4 TLR9 TNF
7 paraneoplastic pemphigus 30.7 COL17A1 DSG3 DST
8 oral squamous cell carcinoma 30.6 KRT13 TLR9 TP53
9 erythema multiforme 30.5 CXCR3 GZMB ICAM1 IFNG TNF
10 myasthenia gravis 30.5 IFNG IL4 TNF
11 keratosis 30.5 FLG IVL KRT10 TP53
12 pemphigoid gestationis 30.4 COL17A1 DST
13 conjunctivitis 30.4 ICAM1 IFNG IL4
14 viral hepatitis 30.4 MX1 TLR9 TNF
15 vulvar intraepithelial neoplasia 30.3 KRT10 TP53
16 linear iga disease 30.3 COL17A1 DST
17 acute graft versus host disease 30.2 GZMB IFNG IL4 TNF
18 filariasis 30.2 IFNG TLR9 TNF
19 cutaneous lupus erythematosus 30.1 CXCR3 GZMB ICAM1 MX1 TNF
20 keratoconjunctivitis 30.0 ICAM1 IFNG IL4 TLR9 TNF
21 keratoacanthoma 30.0 FLG GZMB KRT10 KRT16 TP53
22 bullous pemphigoid 30.0 COL17A1 DSG3 DST IVL
23 alopecia areata 29.9 CXCL9 GZMB ICAM1 IFNG TNF
24 tinea corporis 29.9 DEFB4A KRT16
25 autoimmune disease 29.8 COL17A1 CXCR3 IFNG IL4 TLR9 TNF
26 epidermolytic hyperkeratosis 29.8 FLG KRT10 KRT16
27 discoid lupus erythematosus 29.7 FLG GZMB IVL KRT10 KRT16
28 allergic contact dermatitis 29.6 CXCR3 FLG ICAM1 IFNG IL4 TNF
29 rheumatoid arthritis 29.6 FLG ICAM1 IFNG IL4 ITGAL TNF
30 systemic lupus erythematosus 29.5 CXCR3 ICAM1 IFNG IL4 MX1 TLR9
31 contact dermatitis 29.5 CXCR3 FLG ICAM1 IFNG IL4 KRT16
32 papilloma 29.4 FLG IL4 IVL KRT10 KRT13 TP53
33 asthma 29.4 FLG ICAM1 IFNG IL4 TLR9 TNF
34 lichen disease 29.2 COL17A1 CXCR3 DST ICAM1 IFNG IL4
35 mycosis fungoides 29.1 CXCL9 CXCR3 GZMB ITGAL
36 basal cell carcinoma 29.0 COL17A1 IVL KRT10 KRT16 TP53
37 dermatitis, atopic 28.6 CXCR3 DEFB4A FLG ICAM1 IFNG IL4
38 psoriasis 26.6 CXCL9 CXCR3 DEFB4A FLG ICAM1 IFNG
39 actinic lichen planus 12.7
40 lichen planus pigmentosus 12.7
41 linear lichen planus 12.7
42 oral lichen planus 12.7
43 atrophic lichen planus 12.7
44 annular lichen planus 12.7
45 annular atrophic lichen planus 12.6
46 bullous lichen planus 12.4
47 rare lichen planus 12.4
48 lichen planopilaris 12.1
49 lichen planus, familial 12.1
50 graham-little-piccardi-lassueur syndrome 11.9

Graphical network of the top 20 diseases related to Lichen Planus:



Diseases related to Lichen Planus

Symptoms & Phenotypes for Lichen Planus

UMLS symptoms related to Lichen Planus:


pruritus

GenomeRNAi Phenotypes related to Lichen Planus according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased gamma-H2AX phosphorylation GR00053-A 9.28 CXCR3 DEFB4A DSG3 IVL KRT10 KRT13

MGI Mouse Phenotypes related to Lichen Planus:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.23 IFNG IL4 KRT16 TLR9 TNF TP53

Drugs & Therapeutics for Lichen Planus

Drugs for Lichen Planus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 131)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tacrolimus Approved, Investigational Phase 4,Phase 2 104987-11-3 445643 439492
2
Betamethasone Approved, Vet_approved Phase 4,Phase 3,Phase 2 378-44-9 9782
3
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 124-94-7 31307
4
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1 1994-09-7, 94-09-7 2337
5
Pimecrolimus Approved, Investigational Phase 4,Phase 3,Phase 2 137071-32-0 17753757 6447131
6
Prednisolone Approved, Vet_approved Phase 4,Phase 2 50-24-8 5755
7
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Early Phase 1 22916-47-8 4189
8
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2 83-43-2 6741
9 tannic acid Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Early Phase 1
10
Glucosamine Approved, Investigational, Nutraceutical Phase 4 3416-24-8 439213
11
Chitosan Approved, Nutraceutical Phase 4 9012-76-4 71853
12
Lycopene Approved, Investigational, Nutraceutical Phase 4,Phase 2 502-65-8 446925
13
Lactitol Investigational Phase 4 585-86-4 3871
14 triamcinolone acetonide Phase 4,Phase 3,Phase 2,Early Phase 1
15 Betamethasone Valerate Phase 4,Phase 3,Phase 2 2152-44-5
16 Analgesics Phase 4,Phase 3,Phase 2
17 glucocorticoids Phase 4,Phase 3,Phase 2,Early Phase 1
18 Respiratory System Agents Phase 4,Phase 3,Phase 2
19 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Early Phase 1
20 Triamcinolone diacetate Phase 4,Phase 3,Phase 2,Early Phase 1
21 Triamcinolone hexacetonide Phase 4,Phase 3,Phase 2,Early Phase 1
22 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2
23 Hormone Antagonists Phase 4,Phase 3,Phase 2,Early Phase 1
24 Dermatologic Agents Phase 4,Phase 2,Phase 3,Early Phase 1
25 Hormones Phase 4,Phase 3,Phase 2,Early Phase 1
26 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Early Phase 1
27 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Early Phase 1
28 Anti-Asthmatic Agents Phase 4,Phase 3,Phase 2
29 Antiemetics Phase 4,Phase 3,Phase 2,Early Phase 1
30 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Early Phase 1
31 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
32 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2
33 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1
34 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Early Phase 1
35 Antioxidants Phase 4,Phase 3,Phase 2,Phase 1
36 Betamethasone benzoate Phase 4,Phase 3,Phase 2
37 Betamethasone sodium phosphate Phase 4,Phase 3,Phase 2
38 Betamethasone-17,21-dipropionate Phase 4,Phase 3,Phase 2
39 Autonomic Agents Phase 4,Phase 3,Phase 2,Early Phase 1
40 Antirheumatic Agents Phase 4,Phase 3,Phase 2
41 Calcineurin Inhibitors Phase 4,Phase 3,Phase 2
42 Prednisolone acetate Phase 4,Phase 2
43 Carotenoids Phase 4,Phase 2
44 Methylprednisolone acetate Phase 4,Phase 2
45 Methylprednisolone Hemisuccinate Phase 4,Phase 2
46 Neuroprotective Agents Phase 4
47 Antifungal Agents Phase 4,Phase 3,Early Phase 1
48 Prednisolone hemisuccinate Phase 4,Phase 2
49 Prednisolone phosphate Phase 4,Phase 2
50 Radiation-Protective Agents Phase 4,Phase 2

Interventional clinical trials:

(show top 50) (show all 67)

# Name Status NCT ID Phase Drugs
1 Glucosamine as a Novel Adjunctive Therapy in Oral Lichen Planus Completed NCT02858297 Phase 4 Glucosamine sulfate;triamcinolone acetonide
2 A Clinical Trial to Study the Effects of Two Drugs, Lycopene and Prednisolone in Patients With Oral Lichen Planus Completed NCT02587117 Phase 4 lycopene;Prednisolone
3 Clinical and Immunohistochemical Effect of Topical Pimecrolimus in Treatment of Oral Lichen Planus Completed NCT02443311 Phase 4 Pimecrolimus 1% cream;Betamethasone 17-valerate 0.1% cream
4 The Efficacy of Topical Minocycline in Managing Symptomatic Oral Lichen Planus Unknown status NCT01083420 Phase 3 Minocycline;Dexamethasone
5 Treatment of Female Genital Erosive Lichen Planus(GELP) With Hexaminolevulinate PDT Unknown status NCT01282515 Phase 2, Phase 3 clobetasolpropionate;hexaminolevulinate
6 Evaluation of Green Tea as Antioxidant Agent in Management of Oral Lichen Planus Completed NCT02329600 Phase 3 green tea tablets (Green tea extract 5:1) 200 mg;Triamcinolone Acetonide
7 Efficacy of Elidel Cream on Erosive Oral Lichen Planus Completed NCT00130572 Phase 3 Pimecrolimus
8 Chamaemelum Nobile 2% Versus Placebo Topic Gel to Treat Oral Lichen Planus Completed NCT02421770 Phase 3
9 Efficacy of Topical Rapamycin to Treat Chronic Erosive Oral Lichen Terminated NCT01061853 Phase 3 TOPICAL SIROLIMUS (RAPAMUNE*);TOPICAL BETAMETHASONE 0.05%
10 A Randomized Clinical Trial of the Effect of Pimecrolimus Cream 1% Compared With Topical Corticosteroid in Treatment of Erosive Oral Lichen Planus Unknown status NCT01524744 Phase 2 Pimecrolimus ointment;Adcortyl
11 Pilot Study of Apremilast (CC-10004) in the Treatment of Moderate to Severe Lichen Planus Unknown status NCT01041625 Phase 2 Apremilast (CC-10004)
12 Lichen Planus Mucosae at USZ, Efficacy of Oral Alitretinoin Unknown status NCT01538732 Phase 2 alitretinoin
13 Treatmant of Oral Lichen Planus With Lycopene Completed NCT00656214 Phase 2 Lycopene;Placebo
14 Comparison of Triamcinolone Acetonide Mucoadhesive Film and Licorice Mucoadhesive Film Effect on Lichen Planus Completed NCT02453503 Phase 2 Licorice;Triamcinolone Acetonide
15 Efficacy of Purslane in Treatment of Oral Lichen Planus Completed NCT00746772 Phase 2 Purslane 235mg/day in one dosage;Placebo : one dosage
16 The Efficacy of Omega-3 in Treatment of Atrophic/Erosive Lichen Planus Completed NCT02106468 Phase 2 Prednisone tablet 5mg;Omega-3 soft capsules 1000 mg
17 Pimecrolimus Cream for Oral Lichen Planus Completed NCT00297037 Phase 2 Pimecrolimus 1% cream
18 A Clinical Study of Curcuminoids in the Treatment of Oral Lichen Planus Completed NCT00525421 Phase 2 Curcuminoids;Placebo
19 Comparison of Tacrolimus 0.1% and Clobetasol 0.05% in the Management of Symptomatic Oral Lichen Planus Completed NCT02744378 Phase 2 Tacrolimus 0.1%;Clobetasol 0.05%
20 Cedar Honey in Oral Lichen Planus Completed NCT01974414 Phase 1, Phase 2 orally administered cedar honey
21 Dexamethasone to Treat Oral Lichen Planus Completed NCT00111072 Phase 2 dexamethasone 0.01% solution
22 Hydroxychloroquine vs. Clobetasol Rinse to Treat Oral Lichen Planus Completed NCT00102557 Phase 2 Hydroxychloroquine
23 Study of Metronidazole and Doxycycline to Treat Oral Lichen Planus and to Compare Their Efficacy With Each Other Completed NCT00484250 Phase 2 metronidazole,doxycycline
24 Topical "Non-Aromatic Very Rich in Steranes" (NAVS) Naphthalan for the Treatment of Oral Mucosal Diseases Completed NCT02920658 Phase 2 NAVS Naphthalan;0.05% Betamethasone dipropionate
25 Topical Betamethasone and Clobetasol in Orabase in Oral Lichen Planus Recruiting NCT03026478 Phase 2 Betamethasone Dipropionate;Clobetasol Propionate
26 Dexamethasone Solution for the Treatment of Oral Lichen Planus Recruiting NCT02850601 Phase 2 Dexamethasone
27 Effect of Bifidobacterium Animalis Subsp. Lactis HN019 on Oral Lichen Planus Recruiting NCT03386643 Phase 2 Bifidobacterium animalis subsp. lactis HN019;Clobetasol propionate 0.05%
28 Valchlor in the Treatment of Lichen Planopilaris Recruiting NCT03417141 Phase 2 Valchlor
29 Efficacy of Intralesional Injection of Platelet Rich Plasma in the Treatment of Patients With Erosive Oral Lichen Planus Not yet recruiting NCT03293368 Phase 2 Triamcinolone Acetonide
30 A Randomized, Placebo-Controlled, Double-Blind Clinical Trial of Curcuminoids in Oral Lichen Planus Terminated NCT00226174 Phase 2 Curcuminoids
31 Treatment of Oral Erosive Lichen Planus With Pimecrolimus Cream Terminated NCT00321750 Phase 2 1% pimecrolimus cream
32 A Safety and Efficacy Study of Alefacept in the Treatment of Moderate to Severe Erosive Mucosal Lichen Planus Terminated NCT00135733 Phase 2 Amevive (Alefacept);Placebo
33 Use of Etanercept in the Treatment of Moderate to Severe Lichen Planus Terminated NCT00285779 Phase 2 Etanercept;Placebo
34 Clinical Trials With a Local Anesthetic Lozenge for the Treatment of Chronic Oral Pain Terminated NCT01584947 Phase 2 Bupivacaine;Placebo
35 Free Soft Tissue Graft in Treatment of Oral Lichen Planus Unknown status NCT00737854 Phase 1
36 Therapeutic Effect of Quercetin and the Current Treatment of Erosive and Atrophic Oral Lichen Planus Unknown status NCT01375101 Phase 1 placebo;Quercetin
37 Incidence of Esophageal Lichen Planus in Patients With Known Oral Lichen Planus Unknown status NCT02532166
38 Study of Inflammatory Role of Epstein-Barr Virus (EBV) in Atrophic and Erosive Forms of Oral Lichen Planus Unknown status NCT02276573
39 Based on Metabonomics Dryness Pathogen Type of OLP: a Dynamic Study Unknown status NCT02332486 Qingxuan Decoction
40 Off-Label Use of Ribavirin in Management of Mucocutaneous Extrahepatic Manifestations of HCV Infection Unknown status NCT02261662 Ribavirin;Betamethasone
41 Expression of miRNa-138 and Cyclin D1 in Oral Mucosa of Patients With Oral Lichen Planus Completed NCT02834520
42 Serum Cortisol Levels in Patients With Anxiety and Depression With Symptomatic Oral Lichen Planus Completed NCT03011658
43 Impact of Continuous Defocused CO2 Laser Vaporisation on the Histological Malignant Transformation of Erosive Oral Lichen Planus in Patients Completed NCT02154607
44 The Association Between Diabetes Mellitus, Oral Lichen Planus and Insulin-like Growth Factors 1 and 2 (IGF1 and IGF2) Completed NCT03257228
45 The Use of Probiotics in Patients With Symptomatic Oral Lichen Planus Completed NCT01743690 Nystatin;fluocinolone
46 Safety and Effectiveness of Efalizumab to Treat Oral Lichen Planus Completed NCT00133107 efalizumab
47 Molecular Mechanisms of the Development of Precancerous and Cancerous Lesions of the Oral Cavity Completed NCT03026361
48 Comparison or Rose Bengal and Toluidine Blue Staining for Lesion Detection Efficacy Completed NCT03031899
49 Biomarkers for Oral Cancer Completed NCT00341497
50 Clinical Research Core Dental Screening Protocol Completed NCT00090818

Search NIH Clinical Center for Lichen Planus

Cochrane evidence based reviews: lichen planus

Genetic Tests for Lichen Planus

Anatomical Context for Lichen Planus

The Foundational Model of Anatomy Ontology organs/tissues related to Lichen Planus:

18
Skin, Tongue Or

MalaCards organs/tissues related to Lichen Planus:

38
Skin, Tongue, T Cells, Thyroid, Testes, Liver, Endothelial

Publications for Lichen Planus

Articles related to Lichen Planus:

(show top 50) (show all 1537)
# Title Authors Year
1
Hypertrophic Lichen Planus and Well-Differentiated Squamous Cell Carcinoma: A Diagnostic Conundrum. ( 29360655 )
2018
2
Melanoma in situ mimicking a Lichen planus-like keratosis. ( 29350666 )
2018
3
Participation of the Th17 response in the pathogenesis of oral lichen planus. ( 29314294 )
2018
4
Lichen planus following tetanus-diphtheria-acellular pertussis vaccination: A case report and review of the literature. ( 29326823 )
2018
5
Management of reticular oral lichen planus patients with burning mouth syndrome-like oral symptoms: a pilot study. ( 29308937 )
2018
6
Synchronous presentation of systemic lupus erythematosus and oral reticular lichen planus. ( 29387764 )
2018
7
Lichen planus pigmentosus inversus in children: Case report and updated review of the literature. ( 29231269 )
2018
8
Efficacy of photodynamic therapy in the treatment of symptomatic oral lichen planus: A systematic review. ( 29350426 )
2018
9
Chronic graft versus host disease presenting as lichen planus pigmentosus. ( 29410549 )
2018
10
Psychopathological profile and quality of life of patients with oral lichen planus. ( 29364344 )
2018
11
Bilateral Periorbital Involvement Localized to Eyelids in Lichen Planus Pigmentosus. ( 29441303 )
2018
12
Factors Affecting the Result of Intralesional Corticosteroid Injection in Patients With Oral Lichen Planus. ( 29366304 )
2018
13
Bacillus Calmette-Guerin, polysaccharide nucleic acid in the treatment of cutaneous and oral lichen planus. ( 29405515 )
2018
14
Evaluating the accuracy of microRNA27b and microRNA137 as biomarkers of activity and potential malignant transformation in oral lichen planus patients. ( 29368136 )
2018
15
LPS-induced Vitamin D Receptor Decrease in Oral Keratinocytes Is Associated With Oral Lichen Planus. ( 29335479 )
2018
16
Salivary proteomics in lichen planus: A relationship with pathogenesis? ( 29383810 )
2018
17
Efficacy of photodynamic therapy and low level laser therapy against steroid therapy in the treatment of erosive-atrophic oral lichen planus. ( 29414735 )
2018
18
Association between hepatitis C infection in Thai patients with oral lichen planus: A case-control study. ( 29345111 )
2018
19
Randomized, placebo-controlled, double-blind trial of clobetasol propionate 0.05% in the treatment of oral lichen planus. ( 29297958 )
2018
20
Time-resolved fluorescence spectroscopy for the diagnosis of oral lichen planus. ( 29436013 )
2018
21
The association and potentially destructive role of Th9/IL-9 is synergistic with Th17 cells by elevating MMP9 production in local lesions of oral lichen planus. ( 29412487 )
2018
22
Corneal Involvement by Lichen Planus Pigmentosus. ( 28146367 )
2017
23
Erosive Lichen Planus. ( 28778640 )
2017
24
Incidence of Oral Lichen Planus in Perimenopausal Women: A Cross-sectional Study in Western Uttar Pradesh Population. ( 28706407 )
2017
25
Coexistence of lichen planus follicularis tumidus and Hashimoto's thyroiditis. ( 28954124 )
2017
26
MicroRNAs in cutaneous lichen planus. ( 28940245 )
2017
27
Immune receptors CD40 and CD86 in oral keratinocytes and implications for oral lichen planus. ( 28904313 )
2017
28
Salivary MMP-1, MMP-2, MMP-3 and MMP-13 Levels in Patients with Oral Lichen Planus and Squamous Cell Carcinoma ( 28749626 )
2017
29
Estimation of silver nucleolar organizer regions in oral lichen planus, oral lichenoid reactions and oral lichenoid dysplasia. ( 29391726 )
2017
30
Lichen planus pemphigoides treated with ustekinumab. ( 29360890 )
2017
31
Triggers of oral lichen planus flares and the potential role of trigger avoidance in disease management. ( 28732699 )
2017
32
Clinical and Histopathological Findings of Frontal Fibrosing Alopecia-Associated Lichen Planus Pigmentosus. ( 28560214 )
2017
33
Treatment of oral lichen planus. Systematic review and therapeutic guide. ( 28756997 )
2017
34
Lichen Planus Pemphigoides Induced by Enalapril: A Case Report and a Review of Literature. ( 29282395 )
2017
35
Increased infiltration of CD11 c<sup>+</sup>/CD123<sup>+</sup>dendritic cell subsets and upregulation of TLR/IFN-I+ signaling participate in pathogenesis of oral lichen planus. ( 29429903 )
2017
36
Successful Treatment of Oral Lichen Planus with Direct-Acting Antiviral Agents after Liver Transplantation for Hepatitis C Virus-Associated Hepatocellular Carcinoma. ( 29430221 )
2017
37
Squamous Cell Carcinoma Arising from Hypertrophic Lichen Planus. ( 28761854 )
2017
38
Treatment of oral lichen planus using 308-nm excimer laser. ( 28833900 )
2017
39
Evaluation of photodynamic therapy in treatment of oral erosive lichen planus in comparison with topically applied corticosteroids. ( 28450262 )
2017
40
A clitoral verrucous carcinoma in an area of lichen planus has aggressive features. ( 28061900 )
2017
41
Semaphorin4D Drives CD8(+) T-Cell Lesional Trafficking in Oral Lichen Planus via CXCL9/CXCL10 Upregulations in OralA Keratinocytes. ( 28760660 )
2017
42
Bullous lichen planus - a review. ( 28539981 )
2017
43
Expression of small leucine-rich extracellular matrix proteoglycans biglycan and lumican reveals oral lichen planus malignant potential. ( 28779221 )
2017
44
TRPA1 receptor is upregulated in human oral lichen planus. ( 27718297 )
2017
45
Pembrolizumab-induzierter Lichen planus pemphigoides bei einem Patienten mit metastasiertem Melanom. ( 28677196 )
2017
46
DEFB1 polymorphisms and salivary hBD-1 concentration in Oral Lichen Planus patients and healthy subjects. ( 27770642 )
2017
47
Lichen Planus triggered by infliximab biosimilar CT-P13 and recurred during secukinumab treatment. ( 28940185 )
2017
48
Lichen Planus in Silicosis Patient with Unusually High Antinuclear Antibody Titer. ( 28979026 )
2017
49
IL-17A polymorphism and elevated IL-17A serum levels are associated with oral lichen planus. ( 28741807 )
2017
50
Direct Immunofluorescence as a Helpful Tool for the Differential Diagnosis of Oral Lichen Planus and Oral Lichenoid Lesions. ( 29293127 )
2017

Variations for Lichen Planus

Expression for Lichen Planus

Search GEO for disease gene expression data for Lichen Planus.

Pathways for Lichen Planus

Pathways related to Lichen Planus according to GeneCards Suite gene sharing:

(show all 37)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.72 CXCL9 GZMB ICAM1 IFNG IL4 ITGAL
2
Show member pathways
12.6 ICAM1 IFNG IL4 MX1 TLR9 TNF
3 12.53 GZMB IFNG IL4 TLR9 TNF
4
Show member pathways
12.41 GZMB ICAM1 IFNG IL4 ITGAL TNF
5 12.38 ICAM1 ITGAL TNF TP53
6
Show member pathways
12.34 DSG3 FLG IVL KRT10 KRT13 KRT16
7
Show member pathways
12.29 DEFB4A IFNG IL4 TNF
8 12.26 ICAM1 IFNG ITGAL TP53
9
Show member pathways
12.24 ICAM1 IFNG IL4 TNF TP53
10
Show member pathways
12.17 COL17A1 CXCL9 CXCR3 ICAM1 ITGAL
11 12.15 IFNG TLR9 TNF TP53
12
Show member pathways
12.11 IFNG IL4 MX1 TNF
13
Show member pathways
12.09 DEFB4A IFNG IL4 TLR9 TNF
14 12.06 ICAM1 IFNG TNF TP53
15 11.93 IFNG IL4 ITGAL TNF
16 11.92 ICAM1 IL4 TNF TP53
17
Show member pathways
11.8 GZMB IFNG IL4 TLR9
18 11.8 ICAM1 IFNG IL4 TNF TP53
19 11.78 ICAM1 IFNG ITGAL TNF
20
Show member pathways
11.72 IFNG IL4 TNF
21 11.71 IFNG TLR9 TNF
22 11.71 ICAM1 IFNG IL4 TP53
23
Show member pathways
11.63 ICAM1 IFNG TNF
24
Show member pathways
11.61 GZMB IFNG TNF
25 11.57 ICAM1 ITGAL KRT10
26 11.52 IFNG TNF TP53
27 11.49 ICAM1 IL4 TNF
28 11.46 CXCR3 GZMB IFNG IL4 TNF
29 11.44 ICAM1 IFNG ITGAL
30 11.35 CXCL9 ICAM1 IFNG
31
Show member pathways
11.32 GZMB IFNG TNF
32 11.29 CXCL9 CXCR3 ITGAL
33 11.26 IFNG IL4 TNF
34 11.2 IFNG IL4 TNF
35 11.17 ICAM1 IL4 ITGAL TLR9 TNF
36 11.1 ICAM1 IFNG TLR9 TNF
37 10.71 ICAM1 IFNG ITGAL TLR9 TNF

GO Terms for Lichen Planus

Cellular components related to Lichen Planus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.86 CXCL9 DEFB4A ICAM1 IFNG IL4 KRT10
2 external side of plasma membrane GO:0009897 9.62 CXCL9 CXCR3 ICAM1 TNF
3 intermediate filament GO:0005882 9.35 DST FLG KRT10 KRT13 KRT16
4 hemidesmosome GO:0030056 9.16 COL17A1 DST
5 cornified envelope GO:0001533 8.92 DSG3 FLG IVL KRT10

Biological processes related to Lichen Planus according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.96 CXCL9 DEFB4A IFNG IL4 TNF
2 regulation of immune response GO:0050776 9.83 COL17A1 ICAM1 IL4 ITGAL
3 chemotaxis GO:0006935 9.78 CXCL9 CXCR3 DEFB4A IL4
4 defense response GO:0006952 9.73 CXCL9 DEFB4A MX1 TNF
5 inflammatory response GO:0006954 9.73 CXCL9 CXCR3 ITGAL KRT16 TLR9 TNF
6 movement of cell or subcellular component GO:0006928 9.72 CXCR3 IFNG ITGAL
7 peptide cross-linking GO:0018149 9.69 FLG IVL KRT10
8 positive regulation of nitric oxide biosynthetic process GO:0045429 9.63 ICAM1 IFNG TNF
9 T cell chemotaxis GO:0010818 9.57 CXCL9 CXCR3
10 keratinization GO:0031424 9.55 DSG3 IVL KRT10 KRT13 KRT16
11 response to UV-B GO:0010224 9.54 IVL TP53
12 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.49 ICAM1 TNF
13 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell GO:0002291 9.4 ICAM1 ITGAL
14 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.37 IFNG TNF
15 positive regulation of vitamin D biosynthetic process GO:0060557 9.32 IFNG TNF
16 keratinocyte differentiation GO:0030216 9.26 FLG IVL KRT10 KRT16
17 cornification GO:0070268 9.1 DSG3 FLG IVL KRT10 KRT13 KRT16

Molecular functions related to Lichen Planus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 CXCL9 IFNG IL4 TNF
2 structural constituent of epidermis GO:0030280 9.16 FLG KRT10
3 structural molecule activity GO:0005198 9.02 FLG IVL KRT10 KRT13 KRT16

Sources for Lichen Planus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....