MCID: LCH002
MIFTS: 52

Lichen Planus malady

Skin diseases, Oral diseases categories

Aliases & Classifications for Lichen Planus

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 61UMLS, 27ICD9CM, 56SNOMED-CT, 39NCIt, 33MeSH, 25ICD10
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Aliases & Descriptions for Lichen Planus:

Name: Lichen Planus 8 10 44 61
Lichen, Ruber Planus 8
 
Lichen Ruber Planus 8
Lichen Planus Nos 8


Classifications:



External Ids:

Disease Ontology8 DOID:9201
ICD9CM27 697.0
NCIt39 C3189
MeSH33 D008010
ICD1025 L43

Summaries for Lichen Planus

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Disease Ontology:8 A lichen disease that is located in skin, located in tongue or located in oral mucosa, which presents itself in the form of papules, lesions or rashes. the cause is not known.

MalaCards based summary: Lichen Planus, also known as lichen, ruber planus, is related to oral lichen planus and leukoplakia. An important gene associated with Lichen Planus is CXCR3 (chemokine (C-X-C motif) receptor 3), and among its related pathways are Immune response Role of integrins in NK cells cytotoxicity and Cytoskeleton remodeling Keratin filaments. The compounds dimethyl fumarate and anti-histamine have been mentioned in the context of this disorder. Affiliated tissues include skin, tongue or and skin, and related mouse phenotypes are integument and homeostasis/metabolism.

Wikipedia:64 Lichen planus (LP) is a disease of the skin and/or mucous membranes that resembles lichen. The cause is... more...

Related Diseases for Lichen Planus

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Diseases related to Lichen Planus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 233)
idRelated DiseaseScoreTop Affiliating Genes
1oral lichen planus32.4CD58, CCL5, ICAM1, CXCR3
2leukoplakia31.3DEFB4A, FLG, KRT1, KRT13
3contact dermatitis31.2FLG
4dermatitis31.1FLG, CXCR3, ICAM1, KRT16
5keratosis31.1KRT16, KRT1, KRT10, FLG
6papilloma30.9KRT13, KRT10, FLG
7steatocystoma multiplex30.8KRT16, KRT10
8epidermolytic hyperkeratosis30.8KRT10, KRT1
9keratoderma30.7KRT16, KRT1
10bullous pemphigoid30.5COL17A1, CCL5, FLG, LAMC2
11allergic contact dermatitis30.5FLG, CXCR3, ICAM1
12epidermolysis bullosa30.4LAMC2, FLG, COL17A1
13hypertrophic scars30.4FLG, KRT16
14systemic scleroderma30.4ICAM1, CCL5, CD58
15basal cell carcinoma30.2LAMC2, COL17A1, KRT10, KRT16
16melanoma30.2PECAM1, LAMC2, CXCR3, ICAM1, CD58
17systemic lupus erythematosus30.2CXCR3, ICAM1, CCL5, ITGAM
18pneumonia30.2DEFB4A, ICAM1, CCL5, ITGAM
19atopic dermatitis30.1DEFB4A, FLG, CXCR3, ICAM1, CCL5, ITGAM
20hepatocellular carcinoma30.0CD58, KRT13, KRT1, CCL5
21allergic asthma29.9FLG, ICAM1, CCL5, ITGAM
22psoriasis29.7ICAM1, CCL5, KRT10, KRT1, KRT16, KRT13
23asthma29.6DEFB4A, FLG, CXCR3, ICAM1, CCL5, ITGAM
24adenocarcinoma29.4PECAM1, LAMC2, CCL5, KRT10, KRT1, KRT13
25arthritis29.3PECAM1, FLG, CXCR3, ICAM1, CCL5, ITGAM
26rheumatoid arthritis29.2PECAM1, FLG, CXCR3, ICAM1, CCL5, ITGAM
27lichen planus pemphigoides11.1
28lichen planus pigmentosus11.0
29hepatitis11.0
30hepatitis c11.0
31linear lichen planus11.0
32bullous lichen planus10.9
33atrophic lichen planus10.9
34oral erosive lichen10.9
35actinic lichen planus10.8
36hepatitis c virus10.8
37annular lichen planus10.8
38gingivitis10.7
39annular atrophic lichen planus10.7
40pemphigus10.7
41lupus erythematosus10.7
42lichen sclerosus10.7
43alopecia10.7
44oral leukoplakia10.7
45oral squamous cell carcinoma10.7
46lichen planus follicularis10.7
47blindness10.7
48lichen nitidus10.6
49esophagitis10.6
50discoid lupus erythematosus10.6

Graphical network of the top 20 diseases related to Lichen Planus:



Diseases related to lichen planus

Symptoms for Lichen Planus

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Drugs & Therapeutics for Lichen Planus

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Drug clinical trials:

Search ClinicalTrials for Lichen Planus

Search NIH Clinical Center for Lichen Planus

Genetic Tests for Lichen Planus

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Anatomical Context for Lichen Planus

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MalaCards organs/tissues related to Lichen Planus:

31
Skin, Tongue, T cells, Testes, Thyroid, Endothelial, Liver, Colon, B cells, Lymph node, Monocytes, Nk cells

FMA organs/tissues related to Lichen Planus:

14
Skin, Tongue or

Animal Models for Lichen Planus or affiliated genes

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MGI Mouse Phenotypes related to Lichen Planus:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107717.8LAMC2, FLG, ICAM1, COL17A1, KRT10, KRT1
2MP:00053767.3FLG, CXCR3, ICAM1, ITGAM, KRT1, KRT16
3MP:00107687.2LAMC2, FLG, CXCR3, ICAM1, COL17A1, KRT10
4MP:00053977.0PECAM1, FLG, CXCR3, ICAM1, CCL5, ITGAM
5MP:00053876.0KRT1, PECAM1, LAMC2, FLG, CXCR3, ICAM1

Publications for Lichen Planus

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Articles related to Lichen Planus:

(show top 50)    (show all 1259)
idTitleAuthorsYear
1
Oral lichen planus with antibodies to desmogleins 1 and 3. (25354571)
2014
2
Successful treatment of lichen planus pemphigoides using acitretin as monotherapy. (25087694)
2014
3
Prompt healing of erosive oral lichen planus lesion after combined corticosteroid treatment with locally injected triamcinolone acetonide plus oral prednisolone. (23537868)
2013
4
Homocysteine and other cardiovascular risk factors in patients with lichen planus. (24330130)
2013
5
CIITA rs4774 and rs6498122 polymorphisms are associated with oral lichen planus in Chinese people: a case-control study. (23489895)
2013
6
Oral lichen planus in Arab countries : a review. (24245546)
2013
7
Wickham's striae presented with whitish ring-form on annular lichen planus. (24330176)
2013
8
A case of lichen planus pemphigoides successfully treated with a combination of cyclosporine a and prednisolone. (23626545)
2013
9
Levels of potential oral cancer salivary mRNA biomarkers in oral cancer patients in remission and oral lichen planus patients. (23892499)
2013
10
Altered expression of miR-21, miR-125b, and miR-203 indicates a role for these microRNAs in oral lichen planus. (21943223)
2012
11
Lichen planus and cicatricial conjunctivitis: disease course and response to therapy of 11 patients. (20477930)
2011
12
Lichen planus of the larynx. (21272411)
2011
13
A Case of Lichen Planus Pigmentosus-inversus in a Korean Patient. (21738364)
2011
14
HLA-C/KIR genotypes in oral lichen planus patients infected or non-infected with hepatitis C virus. (20860769)
2011
15
Immunohistochemical assessment of angiogenesis and vascular endothelial growth factor expression in cutaneous lichen planus: relation to the degree of inflammation. (21414893)
2011
16
Circumscribed lenticular anetoderma in an HIV-infected man with a history of syphilis and lichen planus. (22031628)
2011
17
Lichen planus pigmentosus over superficial leg veins. (21251228)
2011
18
Cardiovascular risk factors in patients with lichen planus. (21605731)
2011
19
Heterogeneous disease: a child case of lichen planus pemphigoides triggered by varicella. (21453319)
2011
20
Lichen planus with palmoplantar involvement: rapid therapeutic response to acitretin. (21865117)
2011
21
Lichen planus pemphigoides, a possible example of epitope spreading. (20382044)
2010
22
The quality of patient-orientated Internet information on oral lichen planus: a pilot study. (20586847)
2010
23
In situ amelanotic melanoma of the nail unit mimicking lichen planus: report of 3 cases. (20404232)
2010
24
A retrospective clinicopathological study of 550 patients with oral lichen planus in south-eastern Spain. (20456611)
2010
25
Imiquimod use in the genital area and development of lichen sclerosus and lichen planus. (20215634)
2010
26
Wolf's isotopic response: large annular polycyclic lichen planus occurring on healed lesions of dermatophytosis. (18624876)
2009
27
LCK, survivin and PI-3K in the molecular biomarker profiling of oral lichen planus and oral squamous cell carcinoma. (20975919)
2009
28
Carriage rate and virulence attributes of oral Candida albicans isolates from patients with oral lichen planus: a study in an ethnic Chinese cohort. (18627473)
2009
29
Evaluation of salivary cortisol and psychological factors in patients with oral lichen planus. (19884710)
2009
30
Lichen planus pemphigoides in a 6-year-old child. (19086935)
2009
31
Annular atrophic lichen planus. (17472678)
2007
32
Survival signalling in keratinocytes of erythematous oral lichen planus. (17391299)
2007
33
A combined treatment regimen for desquamative gingivitis in patients with oral lichen planus. (17238974)
2007
34
DNA cytometry of oral leukoplakia and oral lichen planus. (15800471)
2005
35
Linear lichen planus of the face and neck versus amalgam-induced "isotopic" cutaneous lichen planus. (15692500)
2005
36
Annular lichen planus. (15578131)
2004
37
Oral mucosal keratinocytes express RANTES and ICAM-1, but not interleukin-8, in oral lichen planus and oral lichenoid reactions induced by amalgam fillings. (12558634)
2003
38
Linear lichen planus related to hepatitis C infection? (10792256)
2000
39
An atypical verrucous carcinoma of the tongue arising in a patient with oral lichen planus associated with hepatitis C virus infection. (9307733)
1997
40
Apoptosis-associated markers in oral lichen planus. (9176791)
1997
41
Altered interface adhesion molecules in oral lichen planus. (9081757)
1996
42
Hepatitis C and its association with lichen planus and porphyria cutanea tarda. (7868738)
1995
43
Appearance of oral erosive lichen planus during interferon alfa-2a therapy for chronic active hepatitis C. (7650248)
1995
44
Hepatitis C virus infection and oral erosive lichen planus. (7798440)
1994
45
Actinic lichen planus. A clinicopathologic study of 16 patients. (2915056)
1989
46
Bullous lichen planus developed on erythema ab igne. (3537047)
1986
47
Bullous lichen planus: diagnosis by indirect immunofluorescence and treatment with dapsone. (3514699)
1986
48
Bullous lichen planus after intravenous pyelography. (2932478)
1985
49
Deep keratitis associated with atypical lichen planus; report of a case. (18106939)
1948
50
Poikiloderma Jacobi? atrophic lichen planus? (20993126)
1946

Variations for Lichen Planus

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Expression for genes affiliated with Lichen Planus

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Search GEO for disease gene expression data for Lichen Planus.

Pathways for genes affiliated with Lichen Planus

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Compounds for genes affiliated with Lichen Planus

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Compounds related to Lichen Planus according to GeneCards Suite gene sharing:

(show top 50)    (show all 76)
idCompoundScoreTop Affiliating Genes
1dimethyl fumarate4410.3ICAM1, CXCR3
2anti-histamine4410.0CCL5, ICAM1
3tazarotene44 1111.0KRT10, KRT1
4isotretinoin44 1110.9KRT10, KRT1, KRT16
5groalpha449.8CXCR3, CCL5, ICAM1
6tarc449.8CXCR3, CCL5, ICAM1
7loratadine44 24 1111.8CCL5, ICAM1
8ccl344 2810.8CCL5, ICAM1, CXCR3
9mcp 1449.8CXCR3, CCL5
10sp 60012544 6010.7ICAM1, DEFB4A, CCL5
115-oxoete449.7ITGAM, CCL5
12dithranol449.5ICAM1, FLG, KRT16, KRT10
13calcipotriol44 60 28 1112.5KRT16, KRT10, ICAM1, FLG
14fmlp449.3CXCR3, CCL5, ITGAM, ICAM1
15gf 109203x44 6010.3FLG, CCL5, KRT10
16ly294002449.2CCL5, ICAM1, CXCR3, ITGAM
17sb 20358044 6010.2DEFB4A, CCL5, ITGAM, ICAM1
18vitamin d449.2KRT13, KRT10, ITGAM, CCL5
19simvastatin44 50 60 28 24 1114.2CCL5, ICAM1, ITGAM
20genistein44 28 60 1 24 1114.1ITGAM, CCL5, ICAM1, DEFB4A
21pge2449.1ICAM1, ITGAM, CXCR3, CCL5
22endotoxin449.1CXCR3, ICAM1, CCL5, ITGAM, DEFB4A
23p002449.1DEFB4A, PECAM1, ITGAM
24pd 98,059449.0CCL5, ICAM1, ITGAM, CXCR3, DEFB4A
25matrigel449.0CCL5, ICAM1, CXCR3, PECAM1
26slex449.0PECAM1, ITGAM, CD58, ICAM1
27bromodeoxyuridine448.9FLG, KRT10, KRT1
28hematoxylin448.8KRT1, KRT10, PECAM1, FLG
29cytochalasin d44 609.8CCL5, ICAM1, PECAM1
30retinoid448.8KRT10, ITGAM, KRT16, KRT1, FLG
31proline448.7KRT13, CCL5, KRT16, KRT1, KRT10, COL17A1
32calcitriol44 60 24 1111.6KRT10, FLG, CCL5, ITGAM, KRT16
33cyclosporin a44 28 6010.6PECAM1, ICAM1, CCL5, ITGAM
34fibrinogen448.6PECAM1, ICAM1, FLG, ITGAM
35paraffin448.5KRT16, DEFB4A, KRT1, PECAM1, KRT13, KRT10
36dexamethasone44 50 28 1111.4DEFB4A, ITGAM, CCL5, CD58, ICAM1, CXCR3
37heparin44 28 24 1111.4ITGAM, CCL5, CXCR3, PECAM1, DEFB4A
38vegf448.4CXCR3, ICAM1, ITGAM, PECAM1, CCL5
39steroid448.4KRT1, KRT16, CXCR3, KRT10, COL17A1, DEFB4A
40estrogen448.3DEFB4A, KRT1, KRT10, CCL5, PECAM1, CXCR3
41cycloheximide448.3CCL5, PECAM1, ITGAM, COL17A1, ICAM1
42histamine44 28 2410.2DEFB4A, CXCR3, ICAM1, CCL5, PECAM1, ITGAM
43rantes447.9ICAM1, CCL5, DEFB4A, PECAM1, CXCR3, CD58
44cysteine447.7ITGAM, DEFB4A, PECAM1, CCL5, FLG
45nitric oxide44 24 119.6KRT16, ITGAM, PECAM1, FLG, ICAM1, CXCR3
46lipid447.4PECAM1, FLG, DEFB4A, CCL5, ITGAM, KRT1
47serine446.8CXCR3, CCL5, FLG, ITGAM, COL17A1, KRT10
48tyrosine446.6DEFB4A, PECAM1, FLG, CXCR3, ICAM1, CCL5
49calcium44 50 24 119.5KRT13, KRT1, KRT10, COL17A1, ITGAM, CCL5
50retinoic acid44 247.3CCL5, PECAM1, ICAM1, FLG, ITGAM, KRT10

GO Terms for genes affiliated with Lichen Planus

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Cellular components related to Lichen Planus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1keratin filamentGO:00450959.6KRT10, KRT1, KRT13
2intermediate filamentGO:00058829.2KRT16, KRT10, FLG
3external side of plasma membraneGO:00098979.2CXCR3, ICAM1, ITGAM
4extracellular vesicular exosomeGO:00700627.9CD58, PECAM1, ICAM1, KRT10, KRT1, KRT16
5extracellular spaceGO:00056157.8PECAM1, LAMC2, ICAM1, CCL5, KRT10, KRT1
6plasma membraneGO:00058867.5CXCR3, ICAM1, ITGAM, COL17A1, KRT1, CD58

Biological processes related to Lichen Planus according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1cellular response to interleukin-1GO:00713479.7CCL5, ICAM1
2hemidesmosome assemblyGO:00315819.5COL17A1, LAMC2
3cellular response to tumor necrosis factorGO:00713569.5CD58, CCL5, ICAM1
4chemotaxisGO:00069359.4DEFB4A, CXCR3, CCL5
5epidermis developmentGO:00085449.4KRT16, COL17A1, LAMC2
6leukocyte cell-cell adhesionGO:00071599.3ICAM1, CCL5, ITGAM
7cellular response to interferon-gammaGO:00713469.3CD58, CCL5
8leukocyte migrationGO:00509008.7CD58, ITGAM, ICAM1, PECAM1
9extracellular matrix organizationGO:00301988.2PECAM1, LAMC2, ICAM1, ITGAM, COL17A1
10cell adhesionGO:00071558.1CD58, ITGAM, ICAM1, CXCR3, LAMC2, PECAM1

Molecular functions related to Lichen Planus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1receptor activityGO:00048729.6KRT1, ICAM1, CXCR3
2structural molecule activityGO:00051988.9KRT13, KRT1, FLG

Sources for Lichen Planus

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet