MCID: LCH002
MIFTS: 63

Lichen Planus malady

Skin diseases category

Summaries for Lichen Planus

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A lichen disease that is located in skin, located in tongue or located in oral mucosa, which presents itself in the form of papules, lesions or rashes. the cause is not known.

MalaCards: Lichen Planus, also known as lichen, ruber planus, is related to hepatitis c and squamous cell carcinoma. An important gene associated with Lichen Planus is CXCR3 (chemokine (C-X-C motif) receptor 3), and among its related pathways are Integrin Pathway and Signaling by GPCR. The compounds retinoic acid and calcium have been mentioned in the context of this disorder. Affiliated tissues include tongue or, skin and skin, and related mouse phenotypes are immune system and hematopoietic system.

Wikipedia:63 Lichen planus (LP) is a disease of the skin and/or mucous membranes that resembles lichen. The cause is... more...

Aliases & Classifications for Lichen Planus

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

lichen planus 8 10 44 60
lichen, ruber planus 8
lichen ruber planus 8
lichen planus nos 8


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Disease Ontology8 DOID:9201
ICD9CM27 697.0
MeSH34 D008010
NCIt39 C3189
ICD1025 L43

Related Diseases for Lichen Planus

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Lichen Planus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 270)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis c31.4CD58, CXCR3
2squamous cell carcinoma31.2PECAM1, KRT10, KRT13, KRT1, KRT16, MMP1
3pemphigus31.0DST
4keratosis31.0KRT1, KRT16, KRT10, FLG
5gingivitis31.0IL1A, MMP1
6bullous pemphigoid31.0LAMC2, DST, ITGAL, FLG, COL17A1, CCL5
7psoriasis31.0IL1A, KRT16, KRT1, KRT13, KRT10, CXCR3
8oral lichen planus30.9CD58, CXCR3, IL1A, MMP1, TIMP2, CCL5
9dermatitis30.9KRT16, IL1A, CXCR3, FLG, ICAM1
10periodontitis30.8IL1A, MMP1, DEFB4A, TIMP2
11alopecia areata30.7IL1A, ICAM1
12keratoacanthoma30.7KRT10
13hepatitis b30.7ITGAL, CD58
14atopic dermatitis30.6FLG, DEFB4A
15erythema multiforme30.6ICAM1
16melanoma30.6PECAM1, ITGB4, DST, LAMC2, ICAM1, MMP1
17papilloma30.6KRT13, FLG, KRT10
18graft versus host disease30.6ITGAL, PECAM1, CCL5
19viral hepatitis30.6ITGAL
20contact dermatitis30.5FLG, CXCR3, KRT16, IL1A
21diabetes mellitus30.5ITGAM, ICAM1, PECAM1
22rheumatoid arthritis30.3MMP1, FLG, TIMP2, CCL5, ICAM1, ITGAM
23arthritis30.3CXCR3, TIMP2, IL1A, ITGAM, CD58, MMP1
24sarcoidosis30.3ITGAM, DEFB4A, CCL5, IL1A, ICAM1, CXCR3
25epidermolysis bullosa30.3LAMC2, DST, FLG, ITGB4, COL17A1
26systemic lupus erythematosus30.3ITGAM, CXCR3, CCL5, ITGAL, ICAM1
27herpes simplex30.3CCL5, TIMP2
28adenocarcinoma30.1KRT1, ITGB4, TIMP2, LAMC2, KRT13, CCL5
29asthma30.1ITGAM, CCL5, CXCR3, DEFB4A, ICAM1, FLG
30hepatocellular carcinoma30.1CCL5, ITGAL, CD58, TIMP2, KRT1, KRT13
31systemic scleroderma30.1IL1A, CD58, CCL5, MMP1, TIMP2, ICAM1
32allergic asthma30.1ICAM1, ITGAM, ITGAL, FLG, CCL5
33pneumonia30.1CCL5, ITGAM, ICAM1, DEFB4A
34allergic contact dermatitis30.1FLG, CXCR3, ICAM1
35hypertrophic scars30.1KRT16, FLG, MMP1
36vasculitis30.1ITGAM, ICAM1
37epidermolytic hyperkeratosis30.1KRT10, KRT1
38mycosis fungoides30.1ITGAL, CXCR3
39influenza30.1CCL5, CXCR3, ITGAL
40hepatitis11.0
41lichen disease10.9
42hepatitis a10.7
43lupus erythematosus10.7
44alopecia10.7
45linear lichen planus10.6
46lichen planus pigmentosus10.6
47lichen nitidus10.6
48esophagitis10.6
49lichen planus follicularis10.6
50vulvovaginitis10.6

Graphical network of the top 20 diseases related to Lichen Planus:



Diseases related to lichen planus

Clinical Features for Lichen Planus

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Drugs & Therapeutics for Lichen Planus

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Lichen Planus

Drug clinical trials:

Search ClinicalTrials for Lichen Planus

Search NIH Clinical Center for Lichen Planus

Search CenterWatch for Lichen Planus

Genetic Tests for Lichen Planus

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Anatomical Context for Lichen Planus

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Lichen Planus:

32
Skin, Tongue, T cells, Endothelial, Thyroid, Testes, Liver, B cells, Nk cells, Monocytes, Lymph node, Colon, Smooth muscle

FMA organs/tissues related to Lichen Planus:

14
Tongue or, Skin

Animal Models for Lichen Planus or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Lichen Planus:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.1PECAM1, COL17A1, TIMP2, CCL5, ICAM1, ITGB4
2MP:000539710.9CCL5, ICAM1, ITGAM, ITGAL, FLG, DST
3MP:000537610.7TIMP2, ICAM1, ITGB4, ITGAM, ITGAL, FLG
4MP:001077110.6COL17A1, ITGB4, DST, KRT16, KRT1

Publications for Lichen Planus

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50PubMed
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Articles related to Lichen Planus:

(show top 50)    (show all 1192)
idTitleAuthorsYear
1
Comment on "management of vulvovaginal lichen planus: a new approach". (24375030)
2014
2
CIITA rs4774 and rs6498122 polymorphisms are associated with oral lichen planus in Chinese people: a case-control study. (23489895)
2013
3
A case of lichen planus pemphigoides successfully treated with a combination of cyclosporine a and prednisolone. (23626545)
2013
4
Comparison of therapeutic effect of low-dose low-molecular-weight heparin (enoxaparin) vs. oral prednisone in treatment of patients with lichen planus; A clinical trial. (24223391)
2013
5
Reduced immune responses to purified protein derivative and Candida albicans in oral lichen planus. (23607487)
2013
6
Erosive oral lichen planus with cutaneous involvement in a 7-year-old girl: a rare case report. (24021334)
2013
7
Intralesional injection versus mouth rinse of triamcinolone acetonide in oral lichen planus: a randomized controlled study. (23325710)
2013
8
Erratum to: Levels of potential oral cancer salivary mRNA biomarkers in oral cancer patients in remission and oral lichen planus patients. (24173539)
2013
9
Oral lichen planus. (23399399)
2013
10
The evolution of clinicopathologic features in eruptive lichen planus: a case report and review of literature. (23374950)
2013
11
A retrospective comparative study on clinico-pathologic features of oral lichen planus and oral lichenoid lesions. (23946731)
2013
12
Increased P-wave dispersion in patients with newly diagnosed lichen planus. (23778479)
2013
13
Estimation of salivary nitric oxide in recurrent aphthous ulcer and oral lichen planus patients with its clinical significance. (23250164)
2012
14
New perspectives on the dynamic behaviour of oral lichen planus. (22381396)
2012
15
A retrospective clinicopathological study on oral lichen planus and malignant transformation: analysis of 518 cases. (22549677)
2012
16
Unilateral lichen planus along the lines of Blaschko: a rare clinical presentation. (22745149)
2012
17
Treatment of intractable oral lichen planus with intravenous immunoglobulin therapy. (23017943)
2012
18
Pseudoepitheliomatous hyperplasia arising from hypertrophic lichen planus mimicking squamous cell carcinoma: limited value of immunohistochemistry. (22726286)
2012
19
Oral lichen planus and the p53 family: what do we know? (21138483)
2011
20
Expression of T-bet and GATA-3 in peripheral blood mononuclear cells of patients with oral lichen planus. (21163465)
2011
21
Oral lichen planus and malignant transformation: a longitudinal cohort study. (21782485)
2011
22
Antioxidant status in patients with lichen planus. (21883397)
2011
23
Modulation of serum gastric parietal cell antibody level by levamisole and vitamin B12 in oral lichen planus. (20659263)
2011
24
Oral lichen planus. (21093625)
2011
25
Histopathological findings in oral lichen planus and their correlation with the clinical manifestations. (20711121)
2011
26
Quality of life in patients with oral lichen planus. (20367822)
2010
27
Oral pathology quiz. Case number 1. Lichen planus. (20653200)
2010
28
Increased caspase-3 and altered expression of apoptosis-associated proteins, Bcl-2 and Bax in lichen planus. (19309373)
2009
29
The efficacy of topical hyaluronic acid in the management of oral lichen planus. (19267842)
2009
30
Expression of Fas/FasL in patients with oral lichen planus. (19810143)
2009
31
Correlation between clinical and histopathologic diagnoses of oral lichen planus based on modified WHO diagnostic criteria. (19464654)
2009
32
A comparative treatment study of topical tacrolimus and clobetasol in oral lichen planus. (18230389)
2008
33
COX-2 expression in oral lichen planus. (18536521)
2008
34
Oral lichen planus. (18627756)
2008
35
Oral erosive lichen planus and Good's syndrome: just a coincidence or a direct link between the two diseases? (18363920)
2008
36
Expression of novel p53 isoforms in oral lichen planus. (17418619)
2008
37
Oral lichen planus: a condition with more persistence and extra-oral involvement than suspected? (19012620)
2008
38
Lichen planus-like keratosis of the face: a simulator of melanoma in situ. (17598855)
2007
39
Oral lichen planus treated with 13-cis-retinoic acid (isotretinoin): effects on the apoptotic process. (17483968)
2007
40
Lichen planus pemphigoides associated with ramipril. (17184261)
2006
41
Two case reports of cutaneous adverse reactions following hepatitis B vaccine: lichen planus and granuloma annulare. (15324406)
2004
42
Upper gastrointestinal findings in oral lichen planus. (16378271)
2002
43
A clinicopathologic study of scarring alopecia due to lichen planus: comparison with scarring alopecia in discoid lupus erythematosus and pseudopelade. (10446772)
1999
44
Treatment of lichen planus and lichen nitidus with itraconazole: reports of six cases. (9836059)
1998
45
Etretinate suppresses ICAM-1 expression by lesional keratinocytes in healing cutaneous lichen planus. (1979727)
1990
46
Disseminated superficial actinic porokeratosis. A differential diagnosis for lichen planus atrophicus. (2269389)
1990
47
Actinic lichen planus. A clinicopathologic study of 16 patients. (2915056)
1989
48
Hypertrophic bullous lichen planus. (3900186)
1985
49
Differentiating bullous lichen planus and lichen planus pemphigoides. (6392371)
1984
50
Atrophic lichen planus? poikiloderma? (18145557)
1949

Genetic Variations for Lichen Planus

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Expression for genes affiliated with Lichen Planus

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lichen Planus

Search GEO for disease gene expression data for Lichen Planus.

Pathways for genes affiliated with Lichen Planus

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Sources:
51QIAGEN, 53Reactome, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database
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Pathways related to Lichen Planus according to GeneCards/GeneDecks:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.9PECAM1, COL17A1, CCL5, ICAM1, ITGB4, ITGAM
2
Hide members
10.8CCL5, ICAM1, ITGB4, ITGAM, ITGAL, CXCR3
3
Hide members
10.8TIMP2, CCL5, ITGB4, ITGAM, ITGAL, CXCR3
4
Hide members
10.7ICAM1, ITGB4, ITGAM, ITGAL, LAMC2, PECAM1
5
Hide members
10.7TIMP2, ITGB4, ITGAM, ITGAL, CXCR3, LAMC2
6
Hide members
10.7COL17A1, TIMP2, ITGB4, DST, MMP1, LAMC2
7
Hide members
10.7TIMP2, CCL5, ITGB4, ITGAM, ITGAL, IL1A
810.7ICAM1, ITGAM, ITGAL, CD58, PECAM1
910.7ITGAM, ITGAL, CD58, MMP1, PECAM1
1010.7DST, KRT16, KRT1, KRT13
1110.7KRT10, ITGAL, ITGAM, ICAM1
1210.7ICAM1, ITGAM, ITGAL, PECAM1
1310.7COL17A1, ITGB4, DST, LAMC2
1410.7COL17A1, ITGB4, DST, LAMC2
15
Hide members
10.7COL17A1, ITGB4, DST, LAMC2
16
Hide members
10.7LAMC2, ITGAL, ITGB4, COL17A1
17
Hide members
10.6ITGB4, ITGAM, ITGAL, LAMC2
18
Hide members
10.6ITGB4, ITGAM, ITGAL, LAMC2
1910.6ICAM1, ITGAM, ITGAL
2010.6IL1A, ITGB4, COL17A1
21
Cell adhesion Cell-matrix glycoconjugates
Hide members
10.6MMP1, CCL5, TIMP2
22
Cell adhesion ECM remodeling
Hide members
10.6LAMC2, MMP1, TIMP2
2310.6ITGAL, ITGAM, ITGB4
2410.6ITGAL, ITGAM, ITGB4
2510.6PECAM1, ITGAL
2610.5ITGAL

Compounds for genes affiliated with Lichen Planus

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Sources:
44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 2BitterDB
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Compounds related to Lichen Planus according to GeneCards/GeneDecks:

(show top 50)    (show all 110)
idCompoundScoreTop Affiliating Genes
1retinoic acid44 2412.6PECAM1, TIMP2, CCL5, ICAM1, ITGB4, ITGAM
2calcium44 49 11 2414.6KRT10, DST, KRT13, KRT1, ITGAL, MMP1
3tyrosine4411.5CXCR3, ITGB4, ICAM1, CCL5, TIMP2, COL17A1
4serine4411.5ITGAM, CXCR3, COL17A1, PECAM1, IL1A, ITGB4
5nitric oxide44 11 2413.4IL1A, CXCR3, KRT16, FLG, ITGAL, CCL5
6paraffin4411.3KRT13, MMP1, TIMP2, DEFB4A, KRT16, PECAM1
7rantes4411.3ITGAL, IL1A, CXCR3, CD58, DEFB4A, ITGAM
8calcitriol44 59 11 2414.3CCL5, ITGAM, ITGAL, FLG, MMP1, KRT16
9cyclosporin a44 28 5913.2ICAM1, TIMP2, CCL5, ITGAM, ITGAL, IL1A
10heparin44 28 11 2414.2IL1A, TIMP2, CCL5, ITGAM, ITGAL, DEFB4A
11matrigel4411.2MMP1, TIMP2, CCL5, ICAM1, ITGB4, CXCR3
12steroid4411.2KRT16, CXCR3, TIMP2, COL17A1, KRT1, KRT10
13calcipotriol44 59 28 1114.2ICAM1, KRT10, KRT16, IL1A, FLG, ITGB4
14h2o24411.2TIMP2, CCL5, ICAM1, ITGAL, ITGAM, PECAM1
15sb 20358044 5912.2TIMP2, CCL5, ICAM1, ITGAM, IL1A, MMP1
16pd 98,0594411.2CXCR3, MMP1, DEFB4A, ITGAM, ICAM1, TIMP2
17vegf4411.2PECAM1, IL1A, CXCR3, ITGAM, TIMP2, MMP1
18proline4411.2COL17A1, CCL5, KRT10, ITGAL, KRT13, KRT1
19lipid4411.2PECAM1, KRT1, CD58, DEFB4A, FLG, ITGAM
20genistein44 28 59 2 11 2416.1TIMP2, MMP1, IL1A, DEFB4A, ITGAM, ICAM1
21cytochalasin d44 5912.1CCL5, TIMP2, PECAM1, MMP1, ITGAL, ICAM1
22hyaluronic acid44 2412.1MMP1, ITGAL, CD58, IL1A, ICAM1, TIMP2
23dexamethasone44 49 28 1114.1CCL5, ITGAM, ITGAL, CD58, DEFB4A
24fmlp4411.1ITGAL, ITGAM, ICAM1, CCL5, IL1A, CXCR3
25slex4411.1ICAM1, ITGAM, ITGAL, CD58, PECAM1
26retinoid4411.1KRT10, ITGAM, KRT1, MMP1, KRT16, FLG
27endotoxin4411.1ITGAM, CXCR3, DEFB4A, ICAM1
28dithranol4411.1ICAM1, FLG, KRT16, KRT10
29pravastatin44 49 28 11 2415.1ITGAL, MMP1, IL1A, ICAM1, TIMP2
30ascorbic acid44 2412.1TIMP2, ICAM1, MMP1, ITGAM, FLG, IL1A
31progesterone44 59 28 11 2415.0MMP1, KRT10, CXCR3, DEFB4A, TIMP2, KRT1
32histamine44 28 2413.0PECAM1, CCL5, ICAM1, DEFB4A, CXCR3, ITGAM
33hematoxylin4411.0KRT1, MMP1, KRT10, PECAM1
3412-o-tetradecanoylphorbol 13-acetate4411.0KRT1, TIMP2, ITGAM, MMP1, DST, IL1A
35cycloheximide4411.0ITGAM, COL17A1, DST
36fibrinogen4411.0FLG, ITGAL, PECAM1, ICAM1, TIMP2, ITGAM
37groalpha4411.0ICAM1, CXCR3, CCL5, IL1A
38simvastatin44 49 59 28 11 2416.0IL1A, ITGAL, ITGAM, ICAM1, CCL5
39pge24410.9ITGAL
40tarc4410.9CXCR3, ICAM1, CCL5, IL1A
41n-formylmethionyl-leucylphenylalanine4410.9IL1A, ITGAL, ITGAM, ICAM1
42kalinin4410.8LAMC2, ITGB4, DST
43ccl344 2811.8CXCR3, CCL5, IL1A, ICAM1
44nicotine44 49 28 1113.8FLG, KRT1, MMP1, ICAM1, IL1A
45pentoxifylline44 1111.8ICAM1, IL1A, ITGAM, MMP1
46cysteine4410.7PECAM1, DEFB4A, MMP1, TIMP2, FLG, ITGAL
47estrogen4410.7DEFB4A
48fluvastatin44 49 28 1113.7MMP1, ITGAL, ICAM1, IL1A
49pdtc4410.6IL1A, CCL5, MMP1
50aspirin44 49 28 2413.4MMP1, ITGAL, PECAM1, CCL5, ITGAM

GO Terms for genes affiliated with Lichen Planus

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Sources:
16Gene Ontology
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Cellular components related to Lichen Planus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.8COL17A1, TIMP2, CCL5, DEFB4A, IL1A, MMP1
2basement membraneGO:00560410.8ITGB4, DST, COL17A1, TIMP2
3hemidesmosomeGO:03005610.8DST, COL17A1, ITGB4
4intermediate filamentGO:00588210.7KRT10, KRT16, DST, FLG
5integrin complexGO:00830510.6ITGAL, ITGAM, ITGB4
6external side of plasma membraneGO:00989710.6ICAM1, ITGAM, CXCR3, ITGAL
7keratin filamentGO:04509510.3KRT10, KRT13, KRT1

Biological processes related to Lichen Planus according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1cell adhesionGO:00715511.2ICAM1, ITGB4, ITGAM, ITGAL, DST, CD58
2leukocyte migrationGO:05090011.0ICAM1, ITGAM, ITGAL, CD58, MMP1, PECAM1
3extracellular matrix organizationGO:03019811.0MMP1, ITGB4, TIMP2, COL17A1, LAMC2, DST
4hemidesmosome assemblyGO:03158110.9LAMC2, DST, ITGB4, COL17A1
5leukocyte cell-cell adhesionGO:00715910.9ITGAM, CCL5, ICAM1, ITGAL
6integrin-mediated signaling pathwayGO:00722910.9ITGB4, ITGAM, ITGAL, DST
7epidermis developmentGO:00854410.9KRT13, LAMC2, COL17A1, KRT16
8blood coagulationGO:00759610.8PECAM1, ITGAL, CD58, MMP1, ITGAM
9T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cellGO:00229110.7ITGAL, ICAM1
10intermediate filament cytoskeleton organizationGO:04510410.7DST, KRT16
11inflammatory responseGO:00695410.7ITGAL, CXCR3, IL1A, CCL5
12activated T cell proliferationGO:05079810.6ITGAL, ITGAM
13cell junction assemblyGO:03432910.6LAMC2, COL17A1, ITGB4
14extracellular matrix disassemblyGO:02261710.5COL17A1, TIMP2, MMP1
15response to copper ionGO:04668810.3ICAM1, IL1A

Molecular functions related to Lichen Planus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integrin bindingGO:00517810.6DST, ICAM1, TIMP2

Products for genes affiliated with Lichen Planus

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lichen Planus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet