Lichen Planus malady

Disease Ontology: A lichen disease that is located in skin, located in tongue or located in oral mucosa, which presents itself in the form of papules, lesions or rashes. the cause is not known.⁶

MalaCards: Lichen Planus, also known as lichen planus nos (disorder), is related to oral lichen planus and hepatitis. An important gene associated with Lichen Planus is CXCR3 (chemokine (C-X-C motif) receptor 3), and among its related pathways are Graft-versus-host disease and Transendothelial Migration of Leukocytes. The compounds lysine and glucose have been mentioned in the context of this disorder. Affiliated tissues include skin, tongue or and skin, and related mouse phenotypes are respiratory system and craniofacial.

Wikipedia: Lichen planus is a chronic mucocutaneous disease that affects the skin, tongue, and oral mucosa. The...⁴⁴ more...

Aliases & Descriptions:

lichen planus 6 8 32 43 lichen planus nos (disorder) 6 lichen planus (disorder) 6

lichen, ruber planus 6 lichen ruber planus 6 lichen disease 43

Diseases related to lichen planus by text searches and GeneDecks gene sharing:

(show top 50)    (show all 977)

id	Related Disease	Score	Top Affiliating Genes
1	oral lichen planus	41.6	VCAM1, BAX, CD58, MMP1, IL1A, CCR5
2	hepatitis	34.5	CD58, GZMB, IL2RB, FASLG, FAS, IFNA1
3	squamous cell carcinoma	33.9	CD44, CDH1, MKI67, CCND1, CYP2D6, KRT19
4	leukoplakia	33.4	PCNA, BCL2, BAX, CDKN2A, IVL, ITGA2
5	hepatitis c	33.4	MX1, JUN, MMP1, IL10, IL18, IL2
6	bullous pemphigoid	31.8	LAMC2, CD79A, IVL, ITGAL, ITGB4, FLG
7	burning mouth syndrome	30.3	CD14, IL1B, IL2, IL6, TRPV1, TNF
8	keratosis	30.0	PCNA, BCL2, CDKN2A, IVL, MMP1, MMP2
9	vulvovaginitis	29.9	CD79A, IL10, IL4, IL5, MBL2, HSPA4
10	atopic dermatitis	29.3	VCAM1, CD14, CD83, IVL, ITGAM, FLG
11	graft versus host disease	29.0	ITGAL, GZMB, IL10, IL18, IL2, IL2RA
12	lichen sclerosus	28.5	CDKN2A, CD44, IVL, ITGAL, GZMB, FLG
13	mycosis fungoides	28.2	PCNA, VCAM1, BCL2, CDKN2A, CD4, CD1A
14	amyloidosis	28.0	BCL2, CD79A, CD14, CD68, MMP3, MMP9
15	candidiasis	27.6	CD79A, CD4, CD83, MIF, INS, FCGR2A
16	cutaneous malignant melanoma	27.4	PCNA, VEGFA, BCL2, BAX, CEACAM1, CDKN2A
17	viral hepatitis	25.2	PCNA, MX1, BAX, CD58, CD14, CDKN2A
18	insulin resistance	25.1	RELA, VEGFA, VCAM1, JUN, CD14, MMP9
19	oral squamous cell carcinoma	24.7	PDCD1LG2, PCNA, VEGFA, VCAM1, BCL2, SDC1
20	vitiligo	24.3	LPP, BAX, CD79A, CD4, GZMB, IL10
21	dermatitis	23.9	RELA, VEGFA, VCAM1, BCL2, MX1, JUN
22	vasculitis	23.6	VEGFA, VCAM1, CD79A, CD14, CD4, CD68
23	psoriasis	23.5	PCNA, VEGFA, VCAM1, BCL2, MX1, BAX
24	gingivitis	23.3	PCNA, VEGFA, VCAM1, BCL2, SDC1, LAMC2
25	lupus erythematosus	21.1	PDCD1LG2, PCNA, VEGFA, VCAM1, BCL2, SDC1
26	melanoma	20.3	PDCD1LG2, RELA, PCNA, VEGFA, VCAM1, BMP4
27	carcinoma	19.9	PDCD1LG2, RELA, PCNA, VEGFA, LPP, VCAM1
28	bowen syndrome	14.2	PCNA, IVL, MKI67, FLG, KRT16, KRT1
29	contact dermatitis	14.2	FLG, IL1A, IL5, KRT16, CXCL9, CXCR3
30	epidermolysis bullosa simplex	14.2	IVL, ITGB4, FLG, COL7A1, COL17A1, KRT16
31	allergic contact dermatitis of eyelid	14.2	FLG, IL5, ICAM1, CXCL10, CXCL11, CXCL9
32	middle ear cholesteatoma	14.2	PCNA, IVL, MMP1, MMP9, IL1A, ICAM1
33	immune-complex glomerulonephritis	14.1	VCAM1, ITGAL, CCR5, CCR1, ICAM1
34	acanthoma	14.1	PCNA, IVL, KRT16, KRT1, KRT10
35	trichoepithelioma	14.0	BCL2, CDH1, IVL, MKI67, PDPN, KRT10
36	basal cell carcinoma	14.0	BCL2, BAX, LAMC2, CD44, IVL, ITGA2
37	vernal keratoconjunctivitis	14.0	VCAM1, MMP9, IL4, IL5, IL8, CCL5
38	burkitt's lymphoma	14.0	BCL2, BAX, CD27, CDK4, CD44, CD38
39	epidermolytic hyperkeratosis	14.0	FLG, KRT16, KRT1, KRT10, KRT14, KLK8
40	ulceration of vulva	14.0	MMP1, IL2RB, CCR5, CCL5, F13A1, PTGS2
41	synovial sarcoma	13.9	BCL2, CDH1, MKI67, CTNNB1, KRT13, KRT1
42	mucoepidermoid carcinoma	13.9	PCNA, IVL, MKI67, CALCA, TP63, KRT13
43	bullous skin disease	13.9	IL8, CCL5, TNF, COL17A1, DST
44	arterial occlusive disease	13.9	PCNA, VCAM1, IL18, IL1B, IL6, CCR5
45	lymphadenitis	13.9	BAX, CD68, IL2, FASLG, IFNB1, ICAM1
46	alcoholic hepatitis	13.9	IL1A, IL8, CCL5, ICAM1, TNF, SLC17A5
47	papillary thyroid carcinoma	13.9	BAX, CD44, CDH1, CCND1, CALCA, TP63
48	skin carcinoma	13.9	LAMC2, CDK4, CDH1, IVL, MMP2, FLG
49	thymic carcinoma	13.9	BCL2, IL1A, CCL5, CALCA, TP63, PTGS2
50	seminoma	13.9	VCAM1, BCL2, BAX, ITGA3, ITGAL, FASLG

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to lichen planus:

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FMA organs/tissues related to lichen planus:

¹¹

MGI Mouse Phenotypes related to lichen planus:

²⁵ (show all 28)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.6	CD14, FCGR2B, FBN1, F13A1, CALCA, TP63
2	craniofacial phenotype	MP:0005382	10.4	BMP4, FLG, FBN1, COL7A1, KRT16, KRT10
3	endocrine/exocrine gland phenotype	MP:0005379	10.3	ITGA3, IL2, IL2RB, FASLG, IFNG, TP63
4	pigmentation phenotype	MP:0001186	10.0	BCL2, CDKN2A, ITGB2, FBN1, FAS, CASP3
5	renal/urinary system phenotype	MP:0005367	10.0	BMP4, BCL2, BAX, LAMC2, CDK4, ITGA3
6	hematopoietic system phenotype	MP:0005397	9.6	PDCD1LG2, PCNA, BMP4, BCL2, CD27, CD207
7	other phenotype	MP:0005395	9.6	LAMC2, CDKN2A, MMP14, IL2, FBN1, TNFRSF1A
8	embryogenesis phenotype	MP:0005380	9.2	CDK4, IL5, FBN1, ERBB2, TP63, TNFRSF1A
9	limbs/digits/tail phenotype	MP:0005371	9.0	RELA, VEGFA, BMP4, BAX, LAMC2, CD44
10	liver/biliary system phenotype	MP:0005370	9.0	VEGFA, BMP4, INS, FCGR2B, IL2, IL6
11	adipose tissue phenotype	MP:0005375	8.9	BCL2, CD14, INS, IL18, IL6, FBN1
12	reproductive system phenotype	MP:0005389	8.7	VEGFA, CD44, CDH1, MMP14, MMP9, IL10
13	no phenotypic analysis	MP:0003012	8.6	PDCD1LG2, PCNA, VEGFA, VCAM1, BMP4, CD79A
14	digestive/alimentary phenotype	MP:0005381	8.4	VEGFA, BMP4, BCL2, LAMC2, CEACAM1, CDKN2A
15	integument phenotype	MP:0010771	8.3	RELA, BCL2, SDC1, LAMC2, CD4, CDK4
16	immune system phenotype	MP:0005387	8.2	SDC1, LAMC2, CEACAM1, CD79A, CD4, CDK4
17	nervous system phenotype	MP:0003631	7.7	RELA, BMP4, BAX, CD4, CDK4, CD44
18	tumorigenesis	MP:0002006	7.6	PDCD1LG2, BCL2, SDC1, CEACAM1, CDKN2A, CDK4
19	growth/size phenotype	MP:0005378	7.6	RELA, VCAM1, BMP4, BCL2, BAX, JUN
20	skeleton phenotype	MP:0005390	7.5	RELA, VEGFA, BMP4, BAX, LAMC2, JUN
21	vision/eye phenotype	MP:0005391	7.4	RELA, VEGFA, BMP4, BCL2, BAX, JUN
22	muscle phenotype	MP:0005369	7.4	RELA, VEGFA, BMP4, BCL2, BAX, CDKN2A
23	behavior/neurological phenotype	MP:0005386	7.3	BMP4, LAMC2, JUN, CD44, ITGA3, ITGB4
24	normal phenotype	MP:0002873	7.0	RELA, VEGFA, BMP4, CD79A, CD4, CD83
25	mortality/aging	MP:0010768	6.3	PDCD1LG2, RELA, VEGFA, LPP, VCAM1, BMP4
26	cardiovascular system phenotype	MP:0005385	6.1	RELA, VEGFA, VCAM1, BMP4, BCL2, JUN
27	homeostasis/metabolism phenotype	MP:0005376	3.7	PDCD1LG2, RELA, VEGFA, LPP, VCAM1, BMP4
28	cellular phenotype	MP:0005384	3.4	PDCD1LG2, RELA, PCNA, VEGFA, LPP, VCAM1

Articles related to lichen planus:

(show top 50)    (show all 168)

id	Title	Authors	Year	Affiliating Genes
1	Enhanced expression of Toll-like receptor 2 in lesion al tissues and peripheral blood monocytes of patients with oral lichen planus. (21544941)	Ohno S.... Yamamoto T.	2011	TLR2
2	OPN promotes survival of activated T cells by up-regu lating CD44 in patients with oral lichen planus. (21215700)	Liu G.X.... Sun S.Z.	2011	CD44
3	Clinicopathological characteristics of lichen planus pigmentosus and its response to tacrolimus ointment: an open label, non-randomi zed, prospective study. (19840200)	Al-Mutairi N.... El-Khalawany M.	2010	SLC17A5
4	T cells reactive with the NC16A domain of BP180 are p resent in vulval lichen sclerosus and lichen planus. (19686329)	Baldo M.... Wojnarowska F.	2010	ECM1, COL17A1
5	Immunohistochemical study of syndecan-1 down-regulati on and the expression of P35 protein in oral lichen planus: a clinicopathologic correlation with hepatitis C infection in the Egyptian population. (20471559)	Zyada M.M.... Fikry H.E.	2010	SDC1
6	Mannose-binding lectin gene (MBL-2) polymorphism in o ral lichen planus. (20499118)	Barkokebas A.... LeALo J.C.	2010	MBL2
7	Podoplanin and ABCG2: malignant transformation risk m arkers for oral lichen planus. (20200437)	Shi P.... Jiang W.W.	2010	ABCG2, PDPN
8	Comparative analysis of the expression of proliferati ng cell nuclear antigen, p53, bax, and bcl-2 in oral lichen planus and oral squ amous cell carcinoma. (19751907)	de Sousa F.A.... Rosa L.E.	2009	TP53, BCL2, BAX
9	Detection of fascin and CCR-7 positive mature dendritic cells in oral lichen planus. (19243493)	Mukae S.... Komiyama K.	2009	CD1A, CD207
10	Polymorphism of tumor protein p53 codon 72 showed no association with oral lichen planus in Shiraz, Iran. (19884837)	Ghabanchi J.... Paydar A.A.	2009	TP53
11	Association of polymorphisms in the tumor necrosis fa ctor-alpha and interleukin-10 genes with oral lichen planus: a study in a chine se cohort with Han ethnicity. (19450147)	Bai J.... Chen Q.	2009	TNF, IL10
12	Expression of TGF-beta receptors in CD8+ T cells of oral lichen planus (18683732)	Lei L.... Zhan L.H.	2008	TGFBR2, TGFBR1
13	Alteration of the expression of CD44 [corrected] isoforms in oral epithelia and saliva from patients with oral lichen planus. (17846873)	Chaiyarit P.... Chaimusig M.	2008	CD44
14	Oxidative stress markers in oral lichen planus. (19509465)	Battino M.... Totan C.	2008	GGT1
15	Expression of apoptosis related protein in skin lesions of lichen planus and its implication. (18563340)	Chen X.... Liu H.	2008	FAM215A
16	Desmocollin expression in oral atrophic lichen planus correlates with clinical behavior and DNA content. (18422976)	Mattila R.... Syrjanen S.	2008	CDH1, DSC1
17	Changes in the expression of stem cell markers in oral lichen planus and hyperkeratotic lesions. (17634726)	Kose O.... Waseem A.	2007	CSPG4, KRT15
18	Clinical and immunopathologic findings in oral lichen planus pemphigoides. (17531940)	Solomon L.W.... Kumar V.	2007	ITGB4
19	HLA-DRB1*0101 is associated with the genetic susceptibility to develop lichen planus in the Mexican Mestizo population. (17665209)	Luis-Montoya P.... Granados J.	2007	HLA-DRB1
20	Expression of TLR9 and its mRNA in the lesions of lichen planus. (17497298)	Li J.... Liu Z.	2007	TLR9
21	Cytokine gene polymorphisms in hepatitis C virus-related oral lichen planus. (17697145)	Carrozzo M.... Amoroso A.	2007	TNF, IFNG
22	Expressions of NF--kappaBp65, TRAF2, cyclinD1 and their association with cell apoptosis in oral lichen planus (18024283)	Yao X.... Xie S.M.	2007	CCND1, RELA, TRAF2
23	The expression of TNF-alpha and ICAM-1 in lesions of lichen planus and its implication. (18231758)	Chen X.... Yue Q.	2007	ICAM1, TNF
24	The vulvovaginal gingival syndrome: a severe subgroup of lichen planus with characteristic clinical features and a novel association with the class II HLA DQB1*0201 allele. (16781300)	Setterfield J.F.... Black M.M.	2006	HLA-DQB1
25	Proinflammatory cytokine levels in saliva before and after treatment of (erosive) oral lichen planus with dexamethasone. (16476030)	Rhodus N.L.... Ondrey F.	2006	TNF, IL6, IL8
26	Expression profile of chemokines and chemokine receptors in epithelial cell layers of oral lichen planus. (16454813)	Ichimura M.... Yamamoto M.	2006	CXCR3
27	Functions of the cytokines in relation oral lichen planus-hepatitis C. (15800466)	Femiano F.... Scully C.	2005	TGIF1
28	Exacerbation of oral erosive lichen planus by combination of interferon and ribavirin therapy for chronic hepatitis C. (15647837)	Nagao Y.... Sata M.	2005	IFNB1, IFNA1
29	The basement membrane zone and dermal extracellular matrix in erosive lichen planus of the vulva: an immunohistochemical study demonstrating altered expression of hemidesmosome components and anchoring fibrils. (15807689)	Cooper S.M.... Wojnarowska F.	2005	COL17A1
30	The -308 promoter polymorphism in the tumour necrosis factor gene in patients with lichen planus. (16159730)	Krasowska D.... Buraczynska M.	2005	TNF
31	Tumor necrosis factor-alpha and interferon-gamma polymorphisms contribute to susceptibility to oral lichen planus. (14962095)	Carrozzo M.... Gandolfo S.	2004	TNF, IFNG
32	Elevated serum levels of the apoptosis related molecules TNF-alpha, Fas/Apo-1 and Bcl-2 in oral lichen planus. (15250829)	Sklavounou-Andrikopoulou A.... Karameris A.	2004	BCL2
33	The pathogenesis of oral lichen planus. (12191961)	Sugerman P.B.... Bigby M.	2002	TNF, FAS, MIF
34	Successful treatment of lichen planus with low-molecu lar-weight heparin: a case series of seven patients. (12243672)	Pacheco H.... Kerdel F.	2001	HPSE
35	Increased frequency of HLA-DR6 allele in Italian patients with hepatitis C virus-associated oral lichen planus. (11298540)	Carrozzo M.... Ghisetti V.	2001	HLA-DRA
36	Mast cell degranulation and the role of T cell RANTES in oral lichen planus. (11575876)	Zhao Z.Z.... Savage N.W.	2001	TNF, CCL5
37	Disorder-specific changes in innervation in oral lichen planus and lichenoid reactions. (10972344)	Nissalo S.... Konttinen Y.T.	2000	CALCA, NPY
38	Clinical evaluation in oral lichen planus with chronic hepatitis C: the role of interferon treatment (10846411)	Sugiyama T.... Kojima M.	2000	IFNA1
39	Distribution of interleukin-2, -4, -10, tumour necrosis factor-alpha and transforming growth factor-beta mRNAs in oral lichen planus. (10401528)	Simark-Mattsson C.... Dahlgren U.I.	1999	TGFB1, IL2
40	MIG is a dominant lymphocyte-attractant chemokine in lichen planus lesions. (9856808)	Spandau U.... Gillitzer R.	1998	CXCR3, CXCL9
41	Reduction of epithelial dendritic cells in keratotic lesion of oral lichen planus. (9951149)	Mravak-StipetiA8 M.... Vidas I.	1998	CD68
42	Oral lichen planus and HLA A. (9951146)	Ognjenovic M.... Tadin I.	1998	HLA-A
43	Expression of fetal cytokeratins in epidermal cells and colloid bodies in lichen planus. (9508342)	Biermann H.... Rauterberg E.W.	1998	KRT13
44	Apoptosis-associated markers in oral lichen planus. (9176791)	Dekker N.P.... Regezi J.A.	1997	BAX
45	The role of granzyme B-expressing CD8-positive T cells in apoptosis of keratinocytes in lichen planus. (9341973)	Shimizu M.... Kawashima M.	1997	GZMB
46	Vascular adhesion molecules in oral lichen planus. (8784900)	Regezi J.A.... McCalmont T.H.	1996	ICAM1, ITGAL, ITGAM
47	Expression of lymphocyte function-associated antigen 3 in oral lichen planus. (8705826)	Kirby A.C.... Porter S.R.	1995	CD58
48	VCAM-1 and ICAM-1 are expressed by Langerhans cells, macrophages and endothelial cells in oral lichen planus. (7523663)	Walton L.J.... Farthing P.M.	1994	ICAM1, VCAM1
49	Class I and II HLA antigens in British patients with oral lichen planus. (8426716)	Porter K.... Porter S.	1993	HLA-C
50	Lichen planus pemphigoides: case report and results of immunofluorescence and immunoelectron microscopic study. (2180994)	Okochi H.... Tamaki K.	1990	DST

Genes related to lichen planus according to GeneCards:

(show top 50)    (show all 160)

id	Symbol	Description	Score	GeneCards Section Context
1	CXCR3	chemokine (C-X-C motif) receptor 3	11.0	Publications
2	ICAM1	intercellular adhesion molecule 1	11.0	Publications
3	KRT13	keratin 13	11.0	Publications
4	KRT10	keratin 10	11.0	Publications
5	KRT16	keratin 16	11.0	Publications
6	KRT1	keratin 1	11.0	Publications
7	CD58	CD58 molecule	11.0	Publications
8	LAMC2	laminin, gamma 2	11.0	Publications
9	DEFB4A	defensin, beta 4A	11.0	Publications
10	FLG	filaggrin	11.0	Publications
11	PECAM1	platelet/endothelial cell adhesion molecule 1	11.0	Publications
12	ITGAM	integrin, alpha M (complement component 3 receptor 3 subunit)	11.0	Publications
13	CCL5	chemokine (C-C motif) ligand 5	11.0	Publications
14	ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	11.0	Publications
15	TP63	tumor protein p63	11.0	Publications
16	HSPD1	heat shock 60kDa protein 1 (chaperonin)	11.0	Publications
17	HSPA8	heat shock 70kDa protein 8	11.0	Publications
18	HSPA4	heat shock 70kDa protein 4	11.0	Publications
19	TIMP2	TIMP metallopeptidase inhibitor 2	11.0	Publications
20	MMP1	matrix metallopeptidase 1 (interstitial collagenase)	11.0	Publications
21	VCAM1	vascular cell adhesion molecule 1	11.0	Publications
22	BAX	BCL2-associated X protein	11.0	Publications
23	IL1A	interleukin 1, alpha	11.0	Publications
24	CASP3	caspase 3, apoptosis-related cysteine peptidase	11.0	Publications
25	CCR5	chemokine (C-C motif) receptor 5 (gene/pseudogene)	11.0	Publications
26	DDIT4	DNA-damage-inducible transcript 4	11.0	Publications
27	CD1A	CD1a molecule	11.0	Publications
28	CD207	CD207 molecule, langerin	11.0	Publications
29	KRT4	keratin 4	11.0	Publications
30	KRT15	keratin 15	11.0	Publications
31	CD68	CD68 molecule	11.0	Publications
32	PDCD1LG2	programmed cell death 1 ligand 2	11.0	Publications
33	FCGR3B	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)	11.0	Publications
34	FCGR2B	Fc fragment of IgG, low affinity IIb, receptor (CD32)	11.0	Publications
35	FCAR	Fc fragment of IgA, receptor for	11.0	Publications
36	CD27	CD27 molecule	11.0	Publications
37	SDC1	syndecan 1	11.0	Publications
38	CD83	CD83 molecule	11.0	Publications
39	CSPG4	chondroitin sulfate proteoglycan 4	11.0	Publications
40	COL17A1	collagen, type XVII, alpha 1	11.0	Publications
41	CEACAM1	carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)	11.0	Publications
42	GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	11.0	Publications
43	KRT14	keratin 14	11.0	Publications
44	FCGR2A	Fc fragment of IgG, low affinity IIa, receptor (CD32)	11.0	Publications
45	ITGB4	integrin, beta 4	11.0	Publications
46	IVL	involucrin	11.0	Publications
47	MIF	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	11.0	Publications
48	HLA-DRA	major histocompatibility complex, class II, DR alpha	11.0	Publications
49	ITGA3	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	11.0	Publications
50	TRPV1	transient receptor potential cation channel, subfamily V, member 1	11.0	Publications

Pathways related to lichen planus according to GeneDecks:

(show top 50)    (show all 183)

id	Pathway	Score	Top Affiliating Genes
1	Graft-versus-host disease20	10.3	IL1A, IL2, FASLG, HLA-A, HLA-C, HLA-DRA
2	Transendothelial Migration of Leukocytes36	10.3	VCAM1, SDC1, LAMC2, ITGA2, ITGA3, ITGAL
3	Regulation of eIF4 and p70S6K36	10.3	BMP4, BAX, CD4, ITGA2, ITGA3, ITGAL
4	PEDF Induced Signaling36	10.1	RELA, BMP4, BCL2, BAX, IL10, IL18
5	all-trans-Retinoic Acid Signaling in Brain36	10.1	BMP4, BCL2, BAX, IL10, IL18, IL1A
6	MIF Mediated Glucocorticoid Regulation36	10.0	BMP4, BCL2, BAX, CD14, MIF, IL10
7	Malaria20	10.0	VCAM1, SDC1, ITGAL, ITGB2, IL10, IL18
8	Immune response MIF-mediated glucocorticoid regulation10	9.9	RELA, VCAM1, JUN, MMP1, MIF, IL2
9	Immune response_MIF-mediated glucocorticoid regulation41	9.9	RELA, VCAM1, JUN, MMP1, MIF, IL2
10	UPA-UPAR Pathway36	9.8	LAMC2, JUN, ITGA2, ITGA3, ITGAL, ITGAM
11	PTEN Pathway36	9.8	BMP4, LAMC2, ITGA2, ITGA3, ITGAL, ITGAM
12	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.7	BCL2, GZMB, IL2, IL2RA, IL2RB, FASLG
13	PAK Pathway36	9.7	BMP4, BCL2, BAX, IL10, IL18, IL1A
14	Endothelin-1 Signaling Pathway36	9.7	BMP4, IL10, IL18, IL1A, IL1B, IL2
15	MIF Regulation of Innate Immune Cells36	9.6	BMP4, BCL2, BAX, JUN, CD14, MIF
16	Staphylococcus aureus infection20	9.5	ITGAL, ITGAM, ITGB2, FCAR, FCGR2A, FCGR2B
17	PGC1Alpha Pathway36	9.5	BMP4, BCL2, BAX, CD4, IL18, IL1A
18	Toll-like receptor signaling pathway20	9.5	RELA, JUN, CD14, IL1B, IL6, IL8
19	Colorectal Cancer Metastasis36	9.5	BAX, CDH1, MMP1, MMP14, MMP2, MMP9
20	Hematopoietic cell lineage20	9.4	CD14, CD4, CD1A, CD44, CD38, ITGA2
21	Akt Signaling36	9.4	BMP4, CD4, ITGA2, ITGAL, ITGAM, ITGB2
22	Cytokine Network36	9.3	IL10, IL18, IL1A, IL1B, IL2, IL4
23	Phospholipase-C Pathway36	9.2	BMP4, LAMC2, CD79A, ITGA2, ITGA3, ITGAL
24	STAT3 Pathway36	9.2	BMP4, BCL2, BAX, CD4, IL10, IL18
25	Pancreatic Adenocarcinoma36	9.1	BMP4, BCL2, CDKN2A, CDK4, MMP1, MMP2
26	Measles20	9.1	RELA, MX1, CDK4, FCGR2B, IL1A, IL1B
27	ERK Signaling36	9.0	BMP4, LAMC2, ITGA3, ITGAL, ITGAM, ITGB2
28	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.0	IL10, IL2, IL2RA, IL2RB, FASLG, FAS
29	Pathways in cancer20	9.0	RELA, VEGFA, BMP4, BCL2, BAX, JUN
30	Leishmaniasis20	9.0	RELA, JUN, ITGAM, ITGB2, FCGR2A, FCGR3B
31	Autoimmune thyroid disease20	8.9	GZMB, IL10, IL2, IL4, IL5, FASLG
32	Chagas disease (American trypanosomiasis)20	8.9	RELA, JUN, IL10, IL1B, IL2, IL6
33	Molecular Mechanisms of Cancer36	8.8	BMP4, BCL2, BAX, JUN, CDKN2A, CD4
34	Rheumatoid arthritis20	8.8	VEGFA, JUN, ITGAL, ITGB2, MMP1, MMP3
35	THC Differentiation Pathway36	8.7	IL10, IL18, IL2, IL2RA, IL4, IFNG
36	ILK Signaling36	8.7	BMP4, LAMC2, JUN, CDH1, ITGAM, ITGB2
37	Rho Family GTPases36	8.7	BMP4, BCL2, BAX, LAMC2, JUN, CDH1
38	Tuberculosis20	8.7	RELA, BCL2, BAX, CD14, ITGAM, ITGB2
39	Allograft rejection20	8.7	GZMB, IL10, IL2, IL4, IL5, FASLG
40	Influenza A20	8.7	RELA, MX1, JUN, IL18, IL1A, IL1B
41	Antioxidant Action of Vitamin-C36	8.6	BMP4, BCL2, BAX, JUN, CD4, IL10
42	Cytokine-cytokine receptor interaction20	8.5	VEGFA, CD27, IL10, IL18, IL1A, IL1B
43	Glucocorticoid Receptor Signaling36	8.5	BMP4, BCL2, BAX, JUN, CD4, IL10
44	Type I diabetes mellitus20	8.5	GZMB, INS, IL1A, IL1B, IL2, FASLG
45	MAPK Family Pathway36	8.5	BMP4, BCL2, BAX, JUN, CD4, IL10
46	TGF-Beta Pathway36	8.4	BMP4, BCL2, BAX, JUN, CD4, CDH1
47	p38 Signaling36	8.3	BMP4, BCL2, BAX, CD4, IL10, IL18
48	MAPK Signaling36	8.2	BMP4, BCL2, LAMC2, JUN, ITGA2, ITGA3
49	Tec Kinases Signaling36	8.1	BMP4, BCL2, BAX, CD4, ITGA2, ITGA3
50	JAK-STAT Pathway36	7.5	BMP4, BCL2, BAX, JUN, CD4, IL10

Compounds related to lichen planus according to GeneDecks:

(show top 50)    (show all 457)

id	Compound	Score	Top Affiliating Genes
1	lysine32	10.7	RELA, CD58, IVL, FCGR2A, FBN1, GNLY
2	glucose32	10.6	CDK4, CD38, ITGA2, MKI67, GZMB, MIF
3	mitomycin c32	10.6	PCNA, VCAM1, CD58, IL18, FASLG, FAS
4	cytochalasin d32 42	11.5	VCAM1, CD44, CDH1, ITGAL, ITGB2, MMP1
5	procollagen32	10.2	PCNA, MMP1, MMP14, MMP2, MMP3, MMP9
6	lovastatin32 42 9 9	13.1	CDKN2A, CDK4, ITGAL, ITGB2, MMP2, FASLG
7	camptothecin32 42 9 9	13.0	PCNA, BCL2, BAX, JUN, CDKN2A, CDK4
8	mannose32	10.0	CD79A, CD14, CD4, CD207, CD83, CDH1
9	calcitriol32 42 9 18 9	14.0	JUN, CD14, CD83, CDK4, CD44, CDH1
10	cuprophan32	9.9	VCAM1, CD14, ITGAL, ITGAM, ITGB2, IL1B
11	agarose32	9.9	BCL2, BAX, CDKN2A, CD44, MMP14, GZMB
12	mg 13232 42	10.9	PCNA, BAX, JUN, CDKN2A, CDH1, IL1A
13	agar32	9.8	CDKN2A, CDK4, CDH1, MMP14, CCND1, ERBB2
14	12-o-tetradecanoylphorbol 13-acetate32	9.8	CD4, CDK4, CD44, CDH1, IVL, ITGA2
15	sb 20358032 42	10.8	VEGFA, VCAM1, BMP4, BCL2, CDK4, CDH1
16	gm-csf32	9.7	VEGFA, CD14, IL10, IL18, IL1A, IL1B
17	adenylate32	9.7	VCAM1, BMP4, CD44, CDH1, IVL, ITGAM
18	manganese superoxide32	9.7	VCAM1, CD14, IL1A, IL1RN, FASLG, HSPA4
19	polymyxin b32	9.6	VCAM1, CD14, ITGB2, IL10, IL1A, IL1B
20	dopamine32 9 18 9	12.6	CD79A, CDKN2A, MMP9, IL2RA, FAS, IFNB1
21	ciglitazone32	9.5	BAX, JUN, MMP2, MMP9, IL1B, IL6
22	pentoxifylline32 9 9	11.5	VCAM1, CD14, ITGAM, ITGB2, MMP1, MMP2
23	pioglitazone32 9 9	11.4	VEGFA, VCAM1, JUN, MMP1, MMP2, MMP9
24	ibuprofen32 9 18 9	12.4	VCAM1, MMP1, MMP2, MMP3, IL10, IL1B
25	fibrinogen32	9.4	VCAM1, CD79A, CD14, ITGA2, ITGAL, ITGAM
26	oxygen32 18	10.4	BCL2, BAX, JUN, CDKN2A, CDK4, CD44
27	butyrate32	9.3	PCNA, BCL2, BAX, JUN, CD14, CDKN2A
28	polyinosinic-polycytidylic acid32	9.3	VCAM1, CD83, IL10, IL18, IL2, IL4
29	histamine32 18	10.2	PCNA, VCAM1, CD79A, CD14, CDH1, ITGAM
30	calcium32 9 18 9	12.2	RELA, BMP4, CEACAM1, CD27, CD14, CD4
31	triptolide32	9.1	VEGFA, BCL2, BAX, JUN, CD14, MMP3
32	ifn-alpha32	9.0	MX1, CDKN2A, IL10, IL18, IL2, IL2RA
33	celecoxib32 42 34 9 18 9	14.0	PCNA, VEGFA, BCL2, BAX, CDH1, MMP1
34	silymarin32	8.9	PCNA, VEGFA, JUN, CDK4, MMP2, MMP9
35	prednisolone32 9 9	10.9	VCAM1, CD79A, CD14, CD44, ITGAL, ITGAM
36	estrogen32	8.8	PCNA, BMP4, CDH1, IVL, MMP1, MMP14
37	wortmannin32 42	9.7	VCAM1, BCL2, BAX, JUN, CD14, CDH1
38	adriamycin32	8.7	BCL2, BAX, CDKN2A, CD44, CDH1, FASLG
39	5fluorouracil32	8.4	PCNA, VEGFA, BCL2, BAX, CDKN2A, CDK4
40	n acetylcysteine32	8.2	PCNA, VCAM1, CD79A, CDKN2A, CDK4, CDH1
41	glutamate32	8.1	PCNA, CD79A, CD4, CDH1, CD38, ITGA2
42	retinoic acid32 42 18	10.1	VCAM1, BMP4, BAX, CEACAM1, JUN, CD58
43	tacrolimus32 34 9 9	10.9	PCNA, CD79A, CDK4, ITGAL, GZMB, INS
44	neopterin32	7.8	MX1, CD79A, CD14, CD4, CD38, GZMB
45	actinomycin d32	7.7	VEGFA, BMP4, BCL2, BAX, JUN, CDKN2A
46	genistein32 9 18 9	10.4	PCNA, VEGFA, VCAM1, BCL2, BAX, JUN
47	lipid32	7.2	VCAM1, MX1, CEACAM1, CD58, CD14, CDKN2A
48	lactate32	7.1	PCNA, VCAM1, CD79A, CD14, CD44, CDH1
49	arginine32	7.1	CD79A, CD14, CDK4, CD44, ITGB2, GZMB
50	methotrexate32 34 42 9 9	11.1	PCNA, CD79A, CDKN2A, CDH1, IVL, MMP1

Cellular components related to lichen planus according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	intermediate filament	GO:005882	10.6	DST, KRT14, KRT19, KRT15, KRT10, KRT1
2	integrin complex	GO:008305	10.2	ITGB4, ITGB2, ITGAM, ITGAL, ITGA3, ITGA2
3	cell surface	GO:009986	10.1	HSPA8, HSPD1, TNF, TNFRSF1A, TLR2, TIMP2
4	proteinaceous extracellular matrix	GO:005578	9.8	TGFB1, COL14A1, TNC, FBN1, MMP9, MMP3
5	integral to plasma membrane	GO:005887	9.6	COL17A1, TNFRSF1A, TNF, TRPV1, HLA-DRB1, HLA-DRA
6	membrane raft	GO:045121	9.3	RIPK1, SLC6A4, EGFR, TNFRSF1B, TNFRSF1A, TNF
7	external side of plasma membrane	GO:009897	9.2	CXCR3, IL4, IL2RB, ITGAL, ITGA2, CD44
8	extracellular region	GO:005576	7.0	NPY, CSPG4, SOD1, SPP1, TNFRSF1B, TNFRSF1A
9	extracellular space	GO:005615	7.0	FASLG, MIF, MMP9, MMP3, MMP2, CD14
10	plasma membrane	GO:005886	5.9	SMAD7, HSPA8, HSP90AA1, ICAM1, CCR1, CCR5

Biological processes related to lichen planus according to GeneDecks:

(show top 50)    (show all 70)

id	Name	GO ID	Score	Top Affiliating Genes
1	epidermis development	GO:008544	10.9	KRT1, KRT10, KRT15, KRT14, KRT16, KRT13
2	chemotaxis	GO:006935	10.8	C5AR1, CXCR3, CXCL9, CXCL11, CXCL10, DEFB4A
3	activation of pro-apoptotic gene products	GO:008633	10.7	BCL2, BAX, GZMB, FASLG, FAS, TRAF2
4	extracellular matrix disassembly	GO:022617	10.7	TIMP2, TIMP1, MMP9, MMP3, MMP2, MMP14
5	cellular response to organic substance	GO:071310	10.7	TIMP2, CASP3, IL1B, CD68, BAX, BCL2
6	response to cholesterol	GO:070723	10.7	TGFBR2, TGFBR1, TGFB1, CCL5, CCR5
7	positive regulation of T cell proliferation	GO:042102	10.6	IFNG, CCL5, IL6, IL4, IL1B, ITGAL
8	integrin-mediated signaling pathway	GO:007229	10.5	DST, ITGB4, ITGB2, ITGAM, ITGAL, ITGA3
9	extracellular matrix organization	GO:030198	10.4	TIMP2, TIMP1, COL17A1, COL14A1, COL7A1, TNF
10	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	10.4	RIPK1, TNF, TRAF2, HSPD1, IFNB1, FAS
11	positive regulation of interleukin-6 production	GO:032755	10.4	TLR2, TLR9, TNF, HSPD1, IL6, IL1A
12	positive regulation of interleukin-8 production	GO:032757	10.4	IL1B, CALCA, TLR2, TLR9, RIPK1, IL18
13	regulation of immune response	GO:050776	10.3	HLA-A, ICAM1, IL4, FCGR2B, ITGB2, ITGAL
14	induction of apoptosis	GO:006917	10.3	CASP3, TP63, TNF, TLR2, TGFB1, RIPK1
15	positive regulation of chemokine production	GO:032722	10.3	TLR9, TLR2, HIF1A, TNF, IL6, IL18
16	virus-host interaction	GO:019048	10.3	HSPD1, HLA-A, HLA-C, TP53, TNFRSF1A, KRT19
17	positive regulation vascular endothelial growth factor production	GO:010575	10.3	TGFB1, IL1A, IL1B, HPSE, PTGS2, HIF1A
18	cell-cell adhesion	GO:016337	10.2	DSG1, EGFR, PDPN, COL14A1, CTNNB1, CDH1
19	defense response to virus	GO:051607	10.2	CXCL9, CXCL10, PRF1, IFNG, IFNB1, IL6
20	positive regulation of tumor necrosis factor production	GO:032760	10.2	CD14, IL18, IFNG, TNFRSF1A, TLR2, TLR9
21	response to heat	GO:009408	10.1	SOD1, TACR1, CALCA, HSPA4, IL1B, MMP9
22	positive regulation of cytokine secretion	GO:050715	10.1	TLR2, TNF, IL1A, IL10, INS, MIF
23	positive regulation of peptidyl-serine phosphorylation	GO:033138	10.0	TGFB1, TNF, IL6, MIF, CD44, BCL2
24	cell-cell signaling	GO:007267	10.0	CCL5, IFNA2, CALCA, TAC1, CXCL10, CXCL11
25	elevation of cytosolic calcium ion concentration	GO:007204	10.0	C5AR1, CXCR3, TAC1, TACR1, CALCA, CCR1
26	positive regulation of apoptotic process	GO:043065	10.0	TNF, PTGS2, CTNNB1, TOP2A, SOD1, RIPK1
27	response to organic cyclic compound	GO:014070	9.9	PTGS2, ICAM1, CCND1, IL4, IL1RN, IL1A
28	B cell proliferation	GO:042100	9.9	HSPD1, IFNB1, IL10, CD79A, BCL2
29	MAPK cascade	GO:000165	9.9	TGFB1, EGFR, TNF, CCL5, CCR5, IL31RA
30	positive regulation of nitric oxide biosynthetic process	GO:045429	9.8	TLR2, EGFR, PTGS2, TNF, HSP90AA1, ICAM1
31	response to hypoxia	GO:001666	9.8	TNF, TNFRSF1A, DDIT4, HIF1A, TGFB1, SLC6A4
32	positive regulation of smooth muscle cell proliferation	GO:048661	9.8	HIF1A, PTGS2, TNF, CCL5, IL6, JUN
33	aging	GO:007568	9.8	TGFB1, TIMP1, TOP2A, HMGCR, CALCA, CCL5
34	interferon-gamma-mediated signaling pathway	GO:060333	9.8	HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-C, HLA-A, ICAM1
35	response to ethanol	GO:045471	9.8	SOD1, PRF1, TACR1, TNFRSF1A, ICAM1, CCND1
36	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.6	CSPG4, TP53, IL6, IL5, INS, MIF
37	positive regulation of NF-kappaB transcription factor activity	GO:051092	9.5	RIPK1, TGFB1, TLR9, TLR2, TNF, TRAF2
38	inflammatory response	GO:006954	9.5	RELA, CCL5, IFNA2, CALCA, TNF, TNFRSF1A
39	cell adhesion	GO:007155	9.5	CCR1, ICAM1, TNC, SPP1, CTNNB1, COL7A1
40	apoptotic process	GO:006915	9.5	DDIT4, TNFRSF1B, TNFRSF1A, TNF, TP63, CTNNB1
41	negative regulation of apoptotic process	GO:043066	9.3	IL6, HSPD1, CASP3, CAT, TP53, TNF
42	positive regulation of transcription, DNA-dependent	GO:045893	9.3	IL6, TP53, TP63, TNF, CTNNB1, HIF1A
43	negative regulation of cell proliferation	GO:008285	9.3	TNF, PTGS2, CTNNB1, TIMP2, TGFB1, TGIF1
44	cell surface receptor signaling pathway	GO:007166	9.3	IFNB1, IFNG, ERBB2, TRPV1, EGFR, CXCL10
45	innate immune response	GO:045087	9.1	IFNB1, TRAF2, TLR2, TLR9, DEFB4A, RIPK1
46	response to drug	GO:042493	9.1	IL1RN, IL4, FAS, CCND1, CCL5, IFNG
47	immune response	GO:006955	9.1	HLA-DRB1, TLR2, DEFB4A, CXCL10, CXCL11, CXCL9
48	signal transduction	GO:007165	8.9	TNC, PDPN, EGFR, HIF1A, TLR2, TGFBR1
49	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.7	TP63, TNF, TNFRSF1A, CTNNB1, SMAD7, HIF1A
50	cytokine-mediated signaling pathway	GO:019221	8.7	IL6, CCR1, IFNA2, IFNB1, IFNG, ICAM1

Molecular functions related to lichen planus according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	enzyme binding	GO:019899	9.1	CTNNB1, EGFR, HIF1A, TOP2A, TGFB1, CYP2C19
2	cytokine activity	GO:005125	9.0	IL1B, IL2, IL4, IL5, IL6, FASLG
3	protein binding	GO:005515	4.5	TRAF2, KRT14, KLK8, EGFR, ABCG2, HIF1A