MCID: LCH002
MIFTS: 63

Lichen Planus malady

Skin diseases category

Summaries for Lichen Planus

About this section
Sources:
8Disease Ontology, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 A lichen disease that is located in skin, located in tongue or located in oral mucosa, which presents itself in the form of papules, lesions or rashes. the cause is not known.

MalaCards: Lichen Planus, also known as lichen, ruber planus, is related to hepatitis c and squamous cell carcinoma. An important gene associated with Lichen Planus is CXCR3 (chemokine (C-X-C motif) receptor 3), and among its related pathways are Integrin Pathway and Signaling by GPCR. The compounds retinoic acid and calcium have been mentioned in the context of this disorder. Affiliated tissues include tongue or, skin and skin, and related mouse phenotypes are immune system and hematopoietic system.

Wikipedia:63 Lichen planus (LP) is a disease of the skin and/or mucous membranes that resembles lichen. The cause is... more...

Aliases & Classifications for Lichen Planus

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 39NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

lichen planus 8 10 44 60
lichen, ruber planus 8
lichen ruber planus 8
lichen planus nos 8


External Ids:

Disease Ontology8 DOID:9201
ICD9CM27 697.0
MeSH34 D008010
NCIt39 C3189
ICD1025 L43

Related Diseases for Lichen Planus

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Lichen Planus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 270)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis c31.4CD58, CXCR3
2squamous cell carcinoma31.2PECAM1, KRT10, KRT13, KRT1, KRT16, MMP1
3pemphigus31.0DST
4keratosis31.0KRT1, KRT16, KRT10, FLG
5gingivitis31.0IL1A, MMP1
6bullous pemphigoid31.0LAMC2, DST, ITGAL, FLG, COL17A1, CCL5
7psoriasis31.0IL1A, KRT16, KRT1, KRT13, KRT10, CXCR3
8oral lichen planus30.9CD58, CXCR3, IL1A, MMP1, TIMP2, CCL5
9dermatitis30.9KRT16, IL1A, CXCR3, FLG, ICAM1
10periodontitis30.8IL1A, MMP1, DEFB4A, TIMP2
11alopecia areata30.7IL1A, ICAM1
12keratoacanthoma30.7KRT10
13hepatitis b30.7ITGAL, CD58
14atopic dermatitis30.6FLG, DEFB4A
15erythema multiforme30.6ICAM1
16melanoma30.6PECAM1, ITGB4, DST, LAMC2, ICAM1, MMP1
17papilloma30.6KRT13, FLG, KRT10
18graft versus host disease30.6ITGAL, PECAM1, CCL5
19viral hepatitis30.6ITGAL
20contact dermatitis30.5FLG, CXCR3, KRT16, IL1A
21diabetes mellitus30.5ITGAM, ICAM1, PECAM1
22rheumatoid arthritis30.3MMP1, FLG, TIMP2, CCL5, ICAM1, ITGAM
23arthritis30.3CXCR3, TIMP2, IL1A, ITGAM, CD58, MMP1
24sarcoidosis30.3ITGAM, DEFB4A, CCL5, IL1A, ICAM1, CXCR3
25epidermolysis bullosa30.3LAMC2, DST, FLG, ITGB4, COL17A1
26systemic lupus erythematosus30.3ITGAM, CXCR3, CCL5, ITGAL, ICAM1
27herpes simplex30.3CCL5, TIMP2
28adenocarcinoma30.1KRT1, ITGB4, TIMP2, LAMC2, KRT13, CCL5
29asthma30.1ITGAM, CCL5, CXCR3, DEFB4A, ICAM1, FLG
30hepatocellular carcinoma30.1CCL5, ITGAL, CD58, TIMP2, KRT1, KRT13
31systemic scleroderma30.1IL1A, CD58, CCL5, MMP1, TIMP2, ICAM1
32allergic asthma30.1ICAM1, ITGAM, ITGAL, FLG, CCL5
33pneumonia30.1CCL5, ITGAM, ICAM1, DEFB4A
34allergic contact dermatitis30.1FLG, CXCR3, ICAM1
35hypertrophic scars30.1KRT16, FLG, MMP1
36vasculitis30.1ITGAM, ICAM1
37epidermolytic hyperkeratosis30.1KRT10, KRT1
38mycosis fungoides30.1ITGAL, CXCR3
39influenza30.1CCL5, CXCR3, ITGAL
40hepatitis11.0
41lichen disease10.9
42hepatitis a10.7
43lupus erythematosus10.7
44alopecia10.7
45linear lichen planus10.6
46lichen planus pigmentosus10.6
47lichen nitidus10.6
48esophagitis10.6
49lichen planus follicularis10.6
50vulvovaginitis10.6

Graphical network of the top 20 diseases related to Lichen Planus:



Diseases related to lichen planus

Clinical Features for Lichen Planus

About this section

Drugs & Therapeutics for Lichen Planus

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Lichen Planus

Drug clinical trials:

Search ClinicalTrials for Lichen Planus

Search NIH Clinical Center for Lichen Planus

Search CenterWatch for Lichen Planus

Genetic Tests for Lichen Planus

About this section

Anatomical Context for Lichen Planus

About this section
Sources:
32MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Lichen Planus:

32
Skin, Tongue, T cells, Endothelial, Thyroid, Testes, Liver, B cells, Nk cells, Monocytes, Lymph node, Colon, Smooth muscle

FMA organs/tissues related to Lichen Planus:

14
Tongue or, Skin

Animal Models for Lichen Planus or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Lichen Planus:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.1PECAM1, COL17A1, TIMP2, CCL5, ICAM1, ITGB4
2MP:000539710.9CCL5, ICAM1, ITGAM, ITGAL, FLG, DST
3MP:000537610.7TIMP2, ICAM1, ITGB4, ITGAM, ITGAL, FLG
4MP:001077110.6COL17A1, ITGB4, DST, KRT16, KRT1

Publications for Lichen Planus

About this section
Sources:
50PubMed
See all sources

Articles related to Lichen Planus:

(show top 50)    (show all 1192)
idTitleAuthorsYear
1
Clinical variants of lichen planus. (23320493)
2013
2
Differential gene expression in peripheral blood T cells from patients with psoriasis, lichen planus, and atopic dermatitis. (23958114)
2013
3
Photodynamic treatment of oral lichen planus. (24182596)
2013
4
An unusual case of lichen planus? (23522428)
2013
5
T-cell subpopulations in lesions of oral lichen planus. (24280888)
2013
6
Inflammatory cells of immunosuppressive phenotypes in oral lichen planus have a proinflammatory pattern of expression and are associated with clinical parameters. (22893035)
2013
7
The malignant potential of oral lichen planus - reply. (23312534)
2013
8
Lichen planus secondary complications associated with the use of biologic therapy for rheumatoid arthritis. (24322035)
2013
9
Amlexanox is as effective as dexamethasone in topical treatment of erosive oral lichen planus: a short-term pilot study. (22668622)
2012
10
The frequency and malignant transformation rate of oral lichen planus and leukoplakia--a retrospective study. (23213931)
2012
11
Real-life experience of managing vulval erosive lichen planus: a case-based review and U.K. multicentre case note audit. (22384934)
2012
12
Prevalence of hepatitis C and hepatitis B virus infection(s) in patients with oral lichen planus. (23066298)
2012
13
Ki-67 expression in oral lichen planus. (22517707)
2012
14
Mast cells distribution and variations in epithelium thickness and basement membrane in oral lichen planus lesion and oral lichenoid reaction. (22623935)
2012
15
Immunohistochemical assessment of angiogenesis and vascular endothelial growth factor expression in cutaneous lichen planus: relation to the degree of inflammation. (21414893)
2011
16
Mannose-binding lectin gene (MBL-2) polymorphism in oral lichen planus. (20499118)
2011
17
Lichen planus of nails - successful treatment with Alitretinoin. (21883926)
2011
18
HCV and lichen planus: HCV and lichen planus. (22087134)
2011
19
Atypical case of oral lichen planus in a pediatric patient: clinical presentation and management. (22104716)
2011
20
Systemic treatment of cutaneous lichen planus: an update. (21488570)
2011
21
Imiquimod use in the genital area and development of lichen sclerosus and lichen planus. (20215634)
2010
22
Oral lichen planus in childhood: A rare case report. (20804686)
2010
23
Actinic lichen planus in a Japanese man: first case in the East Asian population. (21140994)
2010
24
Oral lichen planus (OLP): clinical and complementary diagnosis. (21152791)
2010
25
A randomized double-blind, positive-control trial of topical thalidomide in erosive oral lichen planus. (20659697)
2010
26
Oral lichen planus versus epithelial dysplasia: difficulties in diagnosis. (19893941)
2009
27
Lichen planus pemphigoides associated with Chinese herbs. (18699839)
2009
28
hTR RNA component as a marker of cellular proliferation in oral lichen planus. (18712976)
2008
29
Association of polymorphisms in the human IFN-gamma and IL-4 gene with oral lichen planus: a study in an ethnic Chinese cohort. (18593330)
2008
30
Linear lichen planus distributed in the lines of Blaschko developing during intramuscular triamcinolone acetonide therapy for alopecia areata multiplex. (18331304)
2008
31
Differences in the expression of p53 protein in oral lichen planus based on the use of monoclonal antibodies DO7 and pAb 240. (17826304)
2008
32
Juvenile oral lichen planus: a report of 2 cases. (18254425)
2007
33
DNA content, Cyclooxygenase-2 expression and loss of E-cadherin expression do not predict risk of malignant transformation in oral lichen planus. (17530268)
2007
34
DNA cytometry of oral leukoplakia and oral lichen planus. (16505806)
2006
35
Expression of matrix metalloproteinases (MMP-2, MMP-3, and MMP-9) and fibronectin in lichen planus. (16919028)
2006
36
Unexpectedly high frequency of genital involvement in women with clinical and histological features of oral lichen planus. (16955190)
2006
37
Successful treatment of severe recalcitrant erosive oral lichen planus with topical tacrolimus. (16405611)
2006
38
Functions of the cytokines in relation oral lichen planus-hepatitis C. (15800466)
2005
39
Laugier-Hunziker syndrome associated with actinic lichen planus. (15009312)
2004
40
Lichen planus pemphigoides and multiple keratoacanthomas associated with colon adenocarcinoma. (15270914)
2004
41
PUVA-induced lichen planus pemphigoides. (10735960)
2000
42
Lichen planus pemphigoides presenting with a strikingly unilateral distribution. (9888340)
1998
43
An atypical verrucous carcinoma of the tongue arising in a patient with oral lichen planus associated with hepatitis C virus infection. (9307733)
1997
44
Immunofluorescent analysis of the basement membrane zone in lichen planus suggests destruction of the lamina lucida in bullous lesions. (8040461)
1994
45
Immunohistochemical studies on fibrillin in amyloidosis, lichen ruber planus and porphyria. (1699374)
1990
46
A case of atrophic lichen planus in association with addisonian pernicious anaemia. (3487399)
1986
47
Trioxsalen baths plus UV-A in the treatment of lichen planus and urticaria pigmentosa. (7261467)
1981
48
Pemphigus vulgaris and pemphigus foliaceus coexisting with oral lichen planus. (6992845)
1980
49
Topical administration of vitamin A acid (retinoic acid) in palmar keratoses: callosities, hyperkeratotic eczema, hypertrophic lichen planus, pityriasis rubra pilaris. (4569794)
1972
50
Linear lichen planus. (20342289)
1947

Genetic Variations for Lichen Planus

About this section

Expression for genes affiliated with Lichen Planus

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Lichen Planus

Search GEO for disease gene expression data for Lichen Planus.

Pathways for genes affiliated with Lichen Planus

About this section
Sources:
51QIAGEN, 53Reactome, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database
See all sources

Pathways related to Lichen Planus according to GeneCards/GeneDecks:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.9PECAM1, COL17A1, CCL5, ICAM1, ITGB4, ITGAM
2
Hide members
10.8CCL5, ICAM1, ITGB4, ITGAM, ITGAL, CXCR3
3
Hide members
10.8TIMP2, CCL5, ITGB4, ITGAM, ITGAL, CXCR3
4
Hide members
10.7ICAM1, ITGB4, ITGAM, ITGAL, LAMC2, PECAM1
5
Hide members
10.7TIMP2, ITGB4, ITGAM, ITGAL, CXCR3, LAMC2
6
Hide members
10.7COL17A1, TIMP2, ITGB4, DST, MMP1, LAMC2
7
Hide members
10.7TIMP2, CCL5, ITGB4, ITGAM, ITGAL, IL1A
810.7ICAM1, ITGAM, ITGAL, CD58, PECAM1
910.7ITGAM, ITGAL, CD58, MMP1, PECAM1
1010.7DST, KRT16, KRT1, KRT13
1110.7KRT10, ITGAL, ITGAM, ICAM1
1210.7ICAM1, ITGAM, ITGAL, PECAM1
1310.7COL17A1, ITGB4, DST, LAMC2
1410.7COL17A1, ITGB4, DST, LAMC2
15
Hide members
10.7COL17A1, ITGB4, DST, LAMC2
16
Hide members
10.7LAMC2, ITGAL, ITGB4, COL17A1
17
Hide members
10.6ITGB4, ITGAM, ITGAL, LAMC2
18
Hide members
10.6ITGB4, ITGAM, ITGAL, LAMC2
1910.6ICAM1, ITGAM, ITGAL
2010.6IL1A, ITGB4, COL17A1
21
Cell adhesion Cell-matrix glycoconjugates
Hide members
10.6MMP1, CCL5, TIMP2
22
Cell adhesion ECM remodeling
Hide members
10.6LAMC2, MMP1, TIMP2
2310.6ITGAL, ITGAM, ITGB4
2410.6ITGAL, ITGAM, ITGB4
2510.6PECAM1, ITGAL
2610.5ITGAL

Compounds for genes affiliated with Lichen Planus

About this section
Sources:
44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 2BitterDB
See all sources

Compounds related to Lichen Planus according to GeneCards/GeneDecks:

(show top 50)    (show all 110)
idCompoundScoreTop Affiliating Genes
1retinoic acid44 2412.6PECAM1, TIMP2, CCL5, ICAM1, ITGB4, ITGAM
2calcium44 49 11 2414.6KRT10, DST, KRT13, KRT1, ITGAL, MMP1
3tyrosine4411.5CXCR3, ITGB4, ICAM1, CCL5, TIMP2, COL17A1
4serine4411.5ITGAM, CXCR3, COL17A1, PECAM1, IL1A, ITGB4
5nitric oxide44 11 2413.4IL1A, CXCR3, KRT16, FLG, ITGAL, CCL5
6paraffin4411.3KRT13, MMP1, TIMP2, DEFB4A, KRT16, PECAM1
7rantes4411.3ITGAL, IL1A, CXCR3, CD58, DEFB4A, ITGAM
8calcitriol44 59 11 2414.3CCL5, ITGAM, ITGAL, FLG, MMP1, KRT16
9cyclosporin a44 28 5913.2ICAM1, TIMP2, CCL5, ITGAM, ITGAL, IL1A
10heparin44 28 11 2414.2IL1A, TIMP2, CCL5, ITGAM, ITGAL, DEFB4A
11matrigel4411.2MMP1, TIMP2, CCL5, ICAM1, ITGB4, CXCR3
12steroid4411.2KRT16, CXCR3, TIMP2, COL17A1, KRT1, KRT10
13calcipotriol44 59 28 1114.2ICAM1, KRT10, KRT16, IL1A, FLG, ITGB4
14h2o24411.2TIMP2, CCL5, ICAM1, ITGAL, ITGAM, PECAM1
15sb 20358044 5912.2TIMP2, CCL5, ICAM1, ITGAM, IL1A, MMP1
16pd 98,0594411.2CXCR3, MMP1, DEFB4A, ITGAM, ICAM1, TIMP2
17vegf4411.2PECAM1, IL1A, CXCR3, ITGAM, TIMP2, MMP1
18proline4411.2COL17A1, CCL5, KRT10, ITGAL, KRT13, KRT1
19lipid4411.2PECAM1, KRT1, CD58, DEFB4A, FLG, ITGAM
20genistein44 28 59 2 11 2416.1TIMP2, MMP1, IL1A, DEFB4A, ITGAM, ICAM1
21cytochalasin d44 5912.1CCL5, TIMP2, PECAM1, MMP1, ITGAL, ICAM1
22hyaluronic acid44 2412.1MMP1, ITGAL, CD58, IL1A, ICAM1, TIMP2
23dexamethasone44 49 28 1114.1CCL5, ITGAM, ITGAL, CD58, DEFB4A
24fmlp4411.1ITGAL, ITGAM, ICAM1, CCL5, IL1A, CXCR3
25slex4411.1ICAM1, ITGAM, ITGAL, CD58, PECAM1
26retinoid4411.1KRT10, ITGAM, KRT1, MMP1, KRT16, FLG
27endotoxin4411.1ITGAM, CXCR3, DEFB4A, ICAM1
28dithranol4411.1ICAM1, FLG, KRT16, KRT10
29pravastatin44 49 28 11 2415.1ITGAL, MMP1, IL1A, ICAM1, TIMP2
30ascorbic acid44 2412.1TIMP2, ICAM1, MMP1, ITGAM, FLG, IL1A
31progesterone44 59 28 11 2415.0MMP1, KRT10, CXCR3, DEFB4A, TIMP2, KRT1
32histamine44 28 2413.0PECAM1, CCL5, ICAM1, DEFB4A, CXCR3, ITGAM
33hematoxylin4411.0KRT1, MMP1, KRT10, PECAM1
3412-o-tetradecanoylphorbol 13-acetate4411.0KRT1, TIMP2, ITGAM, MMP1, DST, IL1A
35cycloheximide4411.0ITGAM, COL17A1, DST
36fibrinogen4411.0FLG, ITGAL, PECAM1, ICAM1, TIMP2, ITGAM
37groalpha4411.0ICAM1, CXCR3, CCL5, IL1A
38simvastatin44 49 59 28 11 2416.0IL1A, ITGAL, ITGAM, ICAM1, CCL5
39pge24410.9ITGAL
40tarc4410.9CXCR3, ICAM1, CCL5, IL1A
41n-formylmethionyl-leucylphenylalanine4410.9IL1A, ITGAL, ITGAM, ICAM1
42kalinin4410.8LAMC2, ITGB4, DST
43ccl344 2811.8CXCR3, CCL5, IL1A, ICAM1
44nicotine44 49 28 1113.8FLG, KRT1, MMP1, ICAM1, IL1A
45pentoxifylline44 1111.8ICAM1, IL1A, ITGAM, MMP1
46cysteine4410.7PECAM1, DEFB4A, MMP1, TIMP2, FLG, ITGAL
47estrogen4410.7DEFB4A
48fluvastatin44 49 28 1113.7MMP1, ITGAL, ICAM1, IL1A
49pdtc4410.6IL1A, CCL5, MMP1
50aspirin44 49 28 2413.4MMP1, ITGAL, PECAM1, CCL5, ITGAM

GO Terms for genes affiliated with Lichen Planus

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Lichen Planus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.8TIMP2, CCL5, DEFB4A, IL1A, MMP1, LAMC2
2basement membraneGO:00560410.8DST, ITGB4, TIMP2, COL17A1
3hemidesmosomeGO:03005610.8DST, ITGB4, COL17A1
4intermediate filamentGO:00588210.7FLG, DST, KRT16, KRT10
5integrin complexGO:00830510.6ITGAL, ITGAM, ITGB4
6external side of plasma membraneGO:00989710.6ICAM1, ITGAM, ITGAL, CXCR3
7keratin filamentGO:04509510.3KRT10, KRT13, KRT1

Biological processes related to Lichen Planus according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1cell adhesionGO:00715511.2PECAM1, ICAM1, ITGB4, ITGAM, ITGAL, DST
2leukocyte migrationGO:05090011.0ICAM1, ITGAM, ITGAL, CD58, MMP1, PECAM1
3extracellular matrix organizationGO:03019811.0COL17A1, TIMP2, ITGB4, DST, MMP1, LAMC2
4hemidesmosome assemblyGO:03158110.9COL17A1, ITGB4, DST, LAMC2
5leukocyte cell-cell adhesionGO:00715910.9ITGAL, ITGAM, ICAM1, CCL5
6integrin-mediated signaling pathwayGO:00722910.9ITGB4, ITGAM, ITGAL, DST
7epidermis developmentGO:00854410.9LAMC2, KRT13, KRT16, COL17A1
8blood coagulationGO:00759610.8PECAM1, MMP1, CD58, ITGAL, ITGAM
9T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cellGO:00229110.7ICAM1, ITGAL
10activated T cell proliferationGO:05079810.7ITGAM, ITGAL
11inflammatory responseGO:00695410.7IL1A, CXCR3, ITGAL, CCL5
12intermediate filament cytoskeleton organizationGO:04510410.6DST, KRT16
13cell junction assemblyGO:03432910.6LAMC2, ITGB4, COL17A1
14extracellular matrix disassemblyGO:02261710.5COL17A1, TIMP2, MMP1
15response to copper ionGO:04668810.3IL1A, ICAM1

Molecular functions related to Lichen Planus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integrin bindingGO:00517810.6DST, ICAM1, TIMP2

Products for genes affiliated with Lichen Planus

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lichen Planus

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet