MCID: LCH002
MIFTS: 53

Lichen Planus malady

Categories: Skin diseases, Rare diseases

Aliases & Classifications for Lichen Planus

Aliases & Descriptions for Lichen Planus:

Name: Lichen Planus 12 52 42 14 69
Lichen, Ruber Planus 12
Lichen Ruber Planus 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9201
ICD10 33 L43 L43.9
ICD9CM 35 697.0
MeSH 42 D008010
NCIt 47 C3189
UMLS 69 C0023646

Summaries for Lichen Planus

Disease Ontology : 12 A lichen disease that is located in skin, located in tongue or located in oral mucosa, which presents itself in the form of papules, lesions or rashes.

MalaCards based summary : Lichen Planus, also known as lichen, ruber planus, is related to burns and nasopharyngitis, and has symptoms including pruritus An important gene associated with Lichen Planus is COL17A1 (Collagen Type XVII Alpha 1 Chain), and among its related pathways/superpathways are Akt Signaling and Cytokine Signaling in Immune system. The drugs Tacrolimus and Betamethasone have been mentioned in the context of this disorder. Affiliated tissues include skin, tongue and t cells.

Wikipedia : 71 Lichen planus (LP) is a disease characterized by itchy reddish-purple polygon-shaped skin lesions on the... more...

Related Diseases for Lichen Planus

Diseases in the Lichen Planus family:

Rare Lichen Planus

Diseases related to Lichen Planus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 330)
id Related Disease Score Top Affiliating Genes
1 burns 30.4 CXCL8 CXCR3 GZMB IFNG TNF
2 nasopharyngitis 29.9 CXCL8 IFNG IL4 TNF
3 colon adenocarcinoma 29.9 CXCL8 IL4 TNF
4 epidermolysis bullosa 29.5 CXCR3 FLG IFNG IL4 KRT16 TNF
5 rheumatoid arthritis 29.3 CCL5 CXCL8 FLG ICAM1 IFNG IL4
6 actinic lichen planus 12.6
7 lichen planus pigmentosus 12.6
8 lichen planus pemphigoides 12.6
9 linear lichen planus 12.6
10 oral lichen planus 12.6
11 atrophic lichen planus 12.5
12 annular lichen planus 12.5
13 annular atrophic lichen planus 12.5
14 bullous lichen planus 12.3
15 rare lichen planus 12.2
16 lichen planopilaris 12.0
17 graham-little-piccardi-lassueur syndrome 11.8
18 vulvovaginal gingival syndrome 11.6
19 lichen nitidus 11.3
20 amyloidosis, primary localized cutaneous, 1 11.0
21 amyloidosis, primary localized cutaneous, 2 11.0
22 nail disorder, nonsyndromic congenital, 1 11.0
23 bier spots 11.0
24 oral erosive lichen 10.9
25 hepatitis 10.6
26 hepatitis c 10.5
27 squamous cell carcinoma 10.5
28 leukoplakia 10.5
29 hepatitis c virus 10.4
30 mucositis 10.4
31 oral squamous cell carcinoma 10.4
32 gingivitis 10.4
33 myoglobinuria recurrent 10.3 IFNG IL4
34 alopecia 10.3
35 plantar wart 10.3 CXCL8 IFNG TNF
36 esophagus lymphoma 10.3 CXCL8 IFNG TNF
37 amyotrophic lateral sclerosis type 14 10.3 CXCL8 IFNG TNF
38 tubular renal disease-cardiomyopathy syndrome 10.3 IL4 TNF
39 lupus erythematosus 10.3
40 pemphigus 10.3
41 oral leukoplakia 10.3
42 conduct disorder 10.3 ICAM1 IFNG TNF
43 parkinson disease 11 10.3 CXCL8 IFNG TNF
44 vps11-related autosomal recessive hypomyelinating leukodystrophy 10.3 CCL5 TNF
45 glucose intolerance 10.3 CXCL8 IFNG TNF
46 senile reticular retinal degeneration 10.3 CXCL8 IFNG TNF
47 autosomal dominant deafness-onychodystrophy syndrome 10.3 IFNG IL4 TNF
48 microcephaly 10.3 ICAM1 IFNG TNF
49 keratosis 10.3
50 cyclosporiasis 10.3 CXCR3 IFNG TNF

Graphical network of the top 20 diseases related to Lichen Planus:



Diseases related to Lichen Planus

Symptoms & Phenotypes for Lichen Planus

UMLS symptoms related to Lichen Planus:


pruritus

Drugs & Therapeutics for Lichen Planus

Drugs for Lichen Planus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 117)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tacrolimus Approved, Investigational Phase 4,Phase 2 104987-11-3 445643 439492
2
Betamethasone Approved, Vet_approved Phase 4,Phase 3,Phase 2 378-44-9 9782
3
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 124-94-7 31307
4
Benzocaine Approved Phase 4,Phase 3,Phase 2 1994-09-7, 94-09-7 2337
5
Pimecrolimus Approved, Investigational Phase 4,Phase 3,Phase 2 137071-32-0 6447131 17753757
6
Prednisolone Approved, Vet_approved Phase 4,Phase 2 50-24-8 5755
7
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3 22916-47-8 4189
8
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2 83-43-2 6741
9 tannic acid Approved, Nutraceutical Phase 4,Phase 3,Phase 2
10
Glucosamine Approved, Nutraceutical Phase 4 3416-24-8 439213
11 triamcinolone acetonide Phase 4,Phase 3,Phase 2
12 Betamethasone Valerate Phase 4,Phase 3,Phase 2 2152-44-5
13 Analgesics Phase 4,Phase 3,Phase 2
14 glucocorticoids Phase 4,Phase 3,Phase 2
15 Gastrointestinal Agents Phase 4,Phase 3,Phase 2
16 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2
17 Dermatologic Agents Phase 4,Phase 2,Phase 3
18 Hormone Antagonists Phase 4,Phase 3,Phase 2
19 Triamcinolone diacetate Phase 4,Phase 3,Phase 2
20 Triamcinolone hexacetonide Phase 4,Phase 3,Phase 2
21 Hormones Phase 4,Phase 3,Phase 2
22 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
23 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2
24 Anti-Asthmatic Agents Phase 4,Phase 3,Phase 2
25 Immunosuppressive Agents Phase 4,Phase 3,Phase 2
26 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1
27 Antiemetics Phase 4,Phase 3,Phase 2
28 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
29 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2
30 Respiratory System Agents Phase 4,Phase 3,Phase 2
31 Antirheumatic Agents Phase 4,Phase 3,Phase 2
32 Autonomic Agents Phase 4,Phase 3,Phase 2
33 Betamethasone benzoate Phase 4,Phase 3,Phase 2
34 Betamethasone sodium phosphate Phase 4,Phase 3,Phase 2
35 Betamethasone-17,21-dipropionate Phase 4,Phase 3,Phase 2
36 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2
37 Calcineurin Inhibitors Phase 4,Phase 3,Phase 2
38 Antioxidants Phase 4,Phase 3,Phase 2,Phase 1
39
Lactitol Phase 4 585-86-4 3871
40 Prednisolone acetate Phase 4,Phase 2
41 Neuroprotective Agents Phase 4
42 Prednisolone hemisuccinate Phase 4,Phase 2
43 Prednisolone phosphate Phase 4,Phase 2
44 Antifungal Agents Phase 4,Phase 3
45 Radiation-Protective Agents Phase 4,Phase 2
46 Methylprednisolone acetate Phase 4,Phase 2
47 Methylprednisolone Hemisuccinate Phase 4,Phase 2
48 Carotenoids Phase 4,Phase 2
49
Chitosan Nutraceutical Phase 4 9012-76-4 71853
50
Lycopene Nutraceutical Phase 4,Phase 2 502-65-8 446925

Interventional clinical trials:

(show top 50) (show all 58)
id Name Status NCT ID Phase
1 Glucosamine as a Novel Adjunctive Therapy in Oral Lichen Planus Completed NCT02858297 Phase 4
2 A Clinical Trial to Study the Effects of Two Drugs, Lycopene and Prednisolone in Patients With Oral Lichen Planus Completed NCT02587117 Phase 4
3 Clinical and Immunohistochemical Effect of Topical Pimecrolimus in Treatment of Oral Lichen Planus Completed NCT02443311 Phase 4
4 The Efficacy of Topical Minocycline in Managing Symptomatic Oral Lichen Planus Unknown status NCT01083420 Phase 3
5 Treatment of Female Genital Erosive Lichen Planus(GELP) With Hexaminolevulinate PDT Unknown status NCT01282515 Phase 2, Phase 3
6 Evaluation of Green Tea as Antioxidant Agent in Management of Oral Lichen Planus Completed NCT02329600 Phase 3
7 Efficacy of Elidel Cream on Erosive Oral Lichen Planus Completed NCT00130572 Phase 3
8 Chamaemelum Nobile 2% Versus Placebo Topic Gel to Treat Oral Lichen Planus Completed NCT02421770 Phase 3
9 Efficacy of Topical Rapamycin to Treat Chronic Erosive Oral Lichen Terminated NCT01061853 Phase 3
10 A Randomized Clinical Trial of the Effect of Pimecrolimus Cream 1% Compared With Topical Corticosteroid in Treatment of Erosive Oral Lichen Planus Unknown status NCT01524744 Phase 2
11 Pilot Study of Apremilast (CC-10004) in the Treatment of Moderate to Severe Lichen Planus Unknown status NCT01041625 Phase 2
12 Lichen Planus Mucosae at USZ, Efficacy of Oral Alitretinoin Unknown status NCT01538732 Phase 2
13 Treatmant of Oral Lichen Planus With Lycopene Completed NCT00656214 Phase 2
14 Pimecrolimus Cream for Oral Lichen Planus Completed NCT00297037 Phase 2
15 Efficacy of Purslane in Treatment of Oral Lichen Planus Completed NCT00746772 Phase 2
16 A Clinical Study of Curcuminoids in the Treatment of Oral Lichen Planus Completed NCT00525421 Phase 2
17 The Efficacy of Omega-3 in Treatment of Atrophic/Erosive Lichen Planus Completed NCT02106468 Phase 2
18 Comparison of Triamcinolone Acetonide Mucoadhesive Film and Licorice Mucoadhesive Film Effect on Lichen Planus Completed NCT02453503 Phase 2
19 Dexamethasone to Treat Oral Lichen Planus Completed NCT00111072 Phase 2
20 Hydroxychloroquine vs. Clobetasol Rinse to Treat Oral Lichen Planus Completed NCT00102557 Phase 2
21 Cedar Honey in Oral Lichen Planus Completed NCT01974414 Phase 1, Phase 2
22 Comparison of Tacrolimus 0.1% and Clobetasol 0.05% in the Management of Symptomatic Oral Lichen Planus Completed NCT02744378 Phase 2
23 Study of Metronidazole and Doxycycline to Treat Oral Lichen Planus and to Compare Their Efficacy With Each Other Completed NCT00484250 Phase 2
24 Topical "Non-Aromatic Very Rich in Steranes" (NAVS) Naphthalan for the Treatment of Oral Mucosal Diseases Completed NCT02920658 Phase 2
25 Topical Betamethasone and Clobetasol in Orabase in Oral Lichen Planus Recruiting NCT03026478 Phase 2
26 Serum Cortisol Levels in Patients With Anxiety and Depression With Symptomatic Oral Lichen Planus Recruiting NCT03011658 Phase 1, Phase 2
27 Dexamethasone Solution for the Treatment of Oral Lichen Planus Not yet recruiting NCT02850601 Phase 2
28 A Randomized, Placebo-Controlled, Double-Blind Clinical Trial of Curcuminoids in Oral Lichen Planus Terminated NCT00226174 Phase 2
29 Treatment of Oral Erosive Lichen Planus With Pimecrolimus Cream Terminated NCT00321750 Phase 2
30 A Safety and Efficacy Study of Alefacept in the Treatment of Moderate to Severe Erosive Mucosal Lichen Planus Terminated NCT00135733 Phase 2
31 Use of Etanercept in the Treatment of Moderate to Severe Lichen Planus Terminated NCT00285779 Phase 2
32 Clinical Trials With a Local Anesthetic Lozenge for the Treatment of Chronic Oral Pain Terminated NCT01584947 Phase 2
33 Free Soft Tissue Graft in Treatment of Oral Lichen Planus Unknown status NCT00737854 Phase 1
34 Therapeutic Effect of Quercetin and the Current Treatment of Erosive and Atrophic Oral Lichen Planus Unknown status NCT01375101 Phase 1
35 Off-Label Use of Ribavirin in Management of Mucocutaneous Extrahepatic Manifestations of HCV Infection Unknown status NCT02261662
36 Expression of miRNa-138 and Cyclin D1 in Oral Mucosa of Patients With Oral Lichen Planus Completed NCT02834520
37 Impact of Continuous Defocused CO2 Laser Vaporisation on the Histological Malignant Transformation of Erosive Oral Lichen Planus in Patients Completed NCT02154607
38 Safety and Effectiveness of Efalizumab to Treat Oral Lichen Planus Completed NCT00133107
39 The Use of Probiotics in Patients With Symptomatic Oral Lichen Planus Completed NCT01743690
40 Molecular Mechanisms of the Development of Precancerous and Cancerous Lesions of the Oral Cavity Completed NCT03026361
41 Comparison or Rose Bengal and Toluidine Blue Staining for Lesion Detection Efficacy Completed NCT03031899
42 Biomarkers for Oral Cancer Completed NCT00341497
43 Clinical Research Core Dental Screening Protocol Completed NCT00090818
44 Evaluation and Treatment of Oral Soft Tissue Diseases Completed NCT00001601
45 Exploratory Study of Natural Killer Cells in Human Skin Completed NCT00824889
46 Salivary and Serum Levels of Chemerin and MMP-9 in Oral Premalignant and Malignant Lesions Completed NCT02323672
47 Incidence of Esophageal Lichen Planus in Patients With Known Oral Lichen Planus Recruiting NCT02532166
48 Study of Inflammatory Role of Epstein-Barr Virus (EBV) in Atrophic and Erosive Forms of Oral Lichen Planus Recruiting NCT02276573
49 Implication of Human Papillomavirus (HPV) in Lichen Physiopathology in Human (HPVLichen) Recruiting NCT02761122
50 The Diagnostic Accuracy of "Three Rings Vulvoscopy" for Detection of Vulvar Dermatosis Recruiting NCT02732145

Search NIH Clinical Center for Lichen Planus

Cochrane evidence based reviews: lichen planus

Genetic Tests for Lichen Planus

Anatomical Context for Lichen Planus

MalaCards organs/tissues related to Lichen Planus:

39
Skin, Tongue, T Cells, Thyroid, Testes, Endothelial, Liver

The Foundational Model of Anatomy Ontology organs/tissues related to Lichen Planus:

18
Skin, Tongue Or

Publications for Lichen Planus

Articles related to Lichen Planus:

(show top 50) (show all 1435)
id Title Authors Year
1
Efficacy of steroidal vs non-steroidal agents in oral lichen planus: a randomised, open-label study. ( 27917729 )
2017
2
Medical treatments for pregnant patients with oral lichen planus. ( 27826983 )
2017
3
Genome-wide Association Study Identifies Risk Variants for Lichen Planus in Patients With Hepatitis C Virus Infection. ( 28065765 )
2017
4
A clitoral verrucous carcinoma in an area of lichen planus has aggressive features. ( 28061900 )
2017
5
Interventions for the management of Oral lichen planus: A review of the conventional and novel therapies. ( 28055124 )
2017
6
Association between the clinical severity of oral lichen planus and anti-TPO level in thyroid patients. ( 28076499 )
2017
7
Identification of AgNORs and cytopathological changes in oral lichen planus lesions. ( 27916273 )
2017
8
TRPA1 may contribute to the exacerbation of oral lichen planus through Koebner phenomenon. ( 28067971 )
2017
9
A case of chilblain lupus erythematosus with lupus erythematosus/lichen planus overlap syndrome. ( 28322475 )
2017
10
DEFB1 polymorphisms and salivary hBD-1 concentration in Oral Lichen Planus patients and healthy subjects. ( 27770642 )
2017
11
Using the BITOLA system to identify candidate molecules in the interaction between oral lichen planus and depression. ( 27913255 )
2017
12
Colocalization of linear lichen planus and psoriasis vulgaris. ( 27730052 )
2016
13
Phenotypically non-suppressive cells predominate among FoxP3-positive cells in oral lichen planus. ( 27084447 )
2016
14
Vulvovaginal gingival lichen planus: report of two cases and review of literature. ( 28042431 )
2016
15
Evaluation of salivary oxidate stress biomarkers, nitric oxide and C-reactive protein in patients with oral lichen planus and burning mouth syndrome. ( 27862315 )
2016
16
Image-based DNA ploidy analysis aids prediction of malignant transformation in oral lichen planus. ( 27084261 )
2016
17
Esophageal involvement is frequent in lichen planus: study in 32 patients with suggestion of clinicopathologic diagnostic criteria and therapeutic implications. ( 27580215 )
2016
18
Elucidating the role of Cyclooxygenase-2 in the pathogenesis of oral lichen planus - an immunohistochemical study with supportive histochemical analysis. ( 27889928 )
2016
19
Oral candidiasis following steroid therapy for oral lichen planus. ( 26599999 )
2016
20
ALK1 expression in oral lichen planus: a possible relation to microvessel density. ( 26662187 )
2016
21
Low-dose oral isotretinoin therapy in lichen planus pigmentosus: an open-label non-randomized prospective pilot study. ( 27062273 )
2016
22
Expression of CD1a by Langerhan's Cells in Oral Lichen Planus - A Retrospective Analysis. ( 27504405 )
2016
23
AAOM Clinical Practice Statement: Subject: Oral lichen planus and oral cancer. ( 27492565 )
2016
24
Clinical observation on the treatment of oral lichen planus with total glucosides of paeony capsule combined with corticosteroids. ( 27129091 )
2016
25
Non-Bullous Lichen Planus Pemphigoides Possibly Induced by Venlafaxine. ( 27124647 )
2016
26
Lack of Relationship between Oral Lichen Planus and Hepatitis B and C Virus Infection: A Report from Southeast of Iran. ( 27530572 )
2016
27
Two cases of erosive oral lichen planus with autoantibodies to desmoglein 3. ( 27458049 )
2016
28
Unilateral zosteriform lichen planus involving multiple noncontiguous dermatomes with oral involvement. ( 27990397 )
2016
29
Distinguishing Erosive Lichen Planus From Differentiated Vulvar Intraepithelial Neoplasia. ( 26796658 )
2016
30
Frequently Increased but Functionally Impaired CD4+CD25+ Regulatory T Cells in Patients with Oral Lichen Planus. ( 27106476 )
2016
31
Lichen planus pigmentosus inversus: a series of 10 Tunisian patients. ( 27152490 )
2016
32
Lichen Planus Pigmentosus: A study for association of Thyroid Dysfunction. ( 27892439 )
2016
33
Cathepsin K expression is increased in oral lichen planus. ( 27152719 )
2016
34
The efficacy of Aloe Vera in management of oral lichen planus: a systematic review and meta-analysis. ( 28029732 )
2016
35
The presence of Helicobacter pylori in oral cavities of patients with leukoplakia and oral lichen planus. ( 27008253 )
2016
36
Serum level of Interleukin-8 in subjects with diabetes, diabetes plus oral lichen planus, and oral lichen planus: A biochemical study. ( 27857766 )
2016
37
Co-localization of Linear Lichen Planus Pigmentosus and Milia in a Child. ( 27057056 )
2016
38
Topical Tocopherol for treatment of reticular oral lichen planus: randomized, double-blind, crossover study. ( 27543905 )
2016
39
Metabolic Derangements in Lichen Planus - A Case Control Study. ( 28050485 )
2016
40
Lichen planus after rabies vaccination: an example of isovaccinetopic response. ( 27653743 )
2016
41
Clinical profile of 108 cases of oral lichen planus. ( 27021539 )
2016
42
The development of proliferative verrucous leukoplakia in oral lichen planus. A preliminary study. ( 27031060 )
2016
43
New-onset oral lichen planus and granulomatous cheilitis in a 66-year-old woman. ( 27222882 )
2016
44
Association of genetic polymorphisms in interferon-I^, interleukin-6 and transforming growth factor-I^1 gene with oral lichen planus susceptibility. ( 27544215 )
2016
45
Annular lichen planus on the mammary areola: an unusual localization. ( 26924029 )
2016
46
Comparison of topical tacrolimus and clobetasol in the management of symptomatic oral lichen planus: A double-blinded, randomized clinical trial in Sri Lanka. ( 27633647 )
2016
47
Alterations in Factors Involved in Differentiation and Barrier Function in the Epithelium in Oral and Genital Lichen Planus. ( 27599552 )
2016
48
Immunohistochemical Expression of Stromelysin-2 (St-2) In Patients with Oral Lichen Planus and Its Clinical Significance. ( 27840837 )
2016
49
Allelic loss in amalgam-associated oral lichenoid lesions compared to oral lichen planus and mucosa. ( 28028908 )
2016
50
Usefulness of micro-biopsy in the follow-up of oral lichen planus. ( 27580656 )
2016

Variations for Lichen Planus

Expression for Lichen Planus

Search GEO for disease gene expression data for Lichen Planus.

Pathways for Lichen Planus

Pathways related to Lichen Planus according to GeneCards Suite gene sharing:

(show all 42)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.41 CCL5 CXCL8 CXCL9 CXCR3 IL4 ITGAL
2
Show member pathways
13.37 CCL5 CXCL8 ICAM1 IFNG IL4 MX1
3
Show member pathways
12.92 CCL5 CXCL8 CXCL9 IFNG TNF TP53
4
Show member pathways
12.71 CXCL8 CXCL9 GZMB ICAM1 IFNG IL4
5
Show member pathways
12.62 CCL5 CXCL8 ICAM1 IFNG IL4 MX1
6 12.55 CCL5 GZMB IFNG IL4 TNF
7
Show member pathways
12.49 FLG IVL KRT10 KRT13 KRT16
8
Show member pathways
12.48 GZMB ICAM1 IFNG IL4 ITGAL TNF
9 12.4 ICAM1 ITGAL TNF TP53
10
Show member pathways
12.33 CCL5 CXCL8 ICAM1 ITGAL
11
Show member pathways
12.32 CXCL8 DEFB4A IFNG IL4 TNF
12 12.29 ICAM1 IFNG ITGAL TP53
13
Show member pathways
12.27 CXCL8 IFNG TNF TP53
14
Show member pathways
12.27 CCL5 ICAM1 IFNG IL4 TNF TP53
15
Show member pathways
12.17 CXCL8 DEFB4A IFNG IL4 TNF
16
Show member pathways
12.12 CXCL8 IFNG IL4 MX1 TNF
17 12.09 ICAM1 IFNG TNF TP53
18
Show member pathways
12.02 CCL5 CXCL8 CXCL9 CXCR3
19 11.99 IFNG IL4 ITGAL TNF
20 11.93 CXCL8 ICAM1 IL4 TNF TP53
21 11.81 CXCL8 ICAM1 IFNG IL4 TNF TP53
22
Show member pathways
11.77 CXCL8 IFNG IL4 TNF
23 11.74 CXCL8 ICAM1 IFNG IL4 TP53
24 11.71 ICAM1 IL4 ITGAL TNF
25 11.71 CXCR3 GZMB IFNG IL4 TNF
26 11.65 CCL5 CXCL8 IL4 TNF
27
Show member pathways
11.64 GZMB IFNG TNF
28
Show member pathways
11.64 CXCL8 ICAM1 IFNG TNF
29 11.6 ICAM1 ITGAL KRT10
30 11.55 IFNG TNF TP53
31 11.44 CXCL8 ICAM1 IFNG ITGAL
32
Show member pathways
11.42 GZMB IFNG TNF
33 11.39 CXCL9 ICAM1 IFNG
34 11.36 ICAM1 IFNG TNF
35 11.33 CXCL9 CXCR3 ITGAL
36 11.29 IFNG IL4 TNF
37 11.26 IFNG IL4 TNF
38 11.24 CCL5 CXCL8 ICAM1 IL4 TNF
39 11.2 CCL5 CXCL8 CXCL9 IL4 TNF
40 11.15 CCL5 CXCL8 TNF
41 11.05 CCL5 CXCL8 ICAM1 IFNG ITGAL TNF
42 11.04 CXCL8 ICAM1 IFNG ITGAL TNF

GO Terms for Lichen Planus

Cellular components related to Lichen Planus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.81 CCL5 CXCL8 CXCL9 DEFB4A ICAM1 IFNG
2 cornified envelope GO:0001533 9.43 FLG IVL KRT10
3 intermediate filament GO:0005882 9.35 DST FLG KRT10 KRT13 KRT16
4 hemidesmosome GO:0030056 9.32 COL17A1 DST
5 external side of plasma membrane GO:0009897 9.1 CXCL9 CXCR3 ICAM1 IFNG IL4 TNF

Biological processes related to Lichen Planus according to GeneCards Suite gene sharing:

(show all 35)
id Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.93 IVL KRT10 KRT13 KRT16
2 cellular response to lipopolysaccharide GO:0071222 9.87 CXCL8 ICAM1 IFNG TNF
3 immune response GO:0006955 9.87 CCL5 CXCL8 CXCL9 DEFB4A IFNG IL4
4 regulation of immune response GO:0050776 9.85 COL17A1 ICAM1 IFNG IL4 ITGAL
5 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.84 ICAM1 IL4 TP53
6 cellular response to interleukin-1 GO:0071347 9.83 CCL5 CXCL8 ICAM1
7 response to virus GO:0009615 9.83 CCL5 IFNG MX1 TNF
8 regulation of insulin secretion GO:0050796 9.82 CCL5 IFNG TNF
9 neutrophil chemotaxis GO:0030593 9.81 CCL5 CXCL8 IFNG
10 positive regulation of T cell proliferation GO:0042102 9.8 CCL5 IFNG IL4
11 peptide cross-linking GO:0018149 9.79 FLG IVL KRT10
12 positive regulation of cell adhesion GO:0045785 9.78 CCL5 IFNG TNF
13 movement of cell or subcellular component GO:0006928 9.78 CXCL8 CXCR3 IFNG ITGAL
14 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.77 CCL5 IFNG IL4
15 positive regulation of nitric oxide biosynthetic process GO:0045429 9.77 ICAM1 IFNG TNF
16 defense response GO:0006952 9.77 CXCL8 CXCL9 DEFB4A MX1 TNF
17 negative regulation of viral genome replication GO:0045071 9.76 CCL5 MX1 TNF
18 keratinocyte differentiation GO:0030216 9.73 FLG IVL KRT10 KRT16
19 chemokine-mediated signaling pathway GO:0070098 9.71 CCL5 CXCL8 CXCL9 CXCR3
20 leukocyte cell-cell adhesion GO:0007159 9.67 CCL5 ICAM1 ITGAL
21 negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 9.66 CCL5 CXCL8
22 positive regulation of isotype switching to IgG isotypes GO:0048304 9.65 IFNG IL4
23 T cell chemotaxis GO:0010818 9.65 CXCL9 CXCR3
24 skin epidermis development GO:0098773 9.64 FLG KRT10
25 neutrophil activation GO:0042119 9.64 CCL5 CXCL8
26 positive regulation of MHC class II biosynthetic process GO:0045348 9.62 IFNG IL4
27 positive regulation of mononuclear cell migration GO:0071677 9.58 IL4 TNF
28 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.56 ICAM1 TNF
29 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell GO:0002291 9.55 ICAM1 ITGAL
30 cornification GO:0070268 9.55 FLG IVL KRT10 KRT13 KRT16
31 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.54 IFNG TNF
32 positive regulation of vitamin D biosynthetic process GO:0060557 9.51 IFNG TNF
33 inflammatory response GO:0006954 9.5 CCL5 CXCL8 CXCL9 CXCR3 ITGAL KRT16
34 positive regulation of chemokine biosynthetic process GO:0045080 9.43 IFNG IL4 TNF
35 chemotaxis GO:0006935 9.1 CCL5 CXCL8 CXCL9 CXCR3 DEFB4A IL4

Molecular functions related to Lichen Planus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 9.56 FLG IVL KRT13 KRT16
2 chemokine activity GO:0008009 9.13 CCL5 CXCL8 CXCL9
3 cytokine activity GO:0005125 9.1 CCL5 CXCL8 CXCL9 IFNG IL4 TNF
4 protein binding GO:0005515 10.09 CCL5 COL17A1 CXCL8 CXCL9 DEFB4A DST

Sources for Lichen Planus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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