MCID: LCH002
MIFTS: 61

Lichen Planus malady

Skin category

Summaries for Lichen Planus

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A lichen disease that is located in skin, located in tongue or located in oral mucosa, which presents itself in the form of papules, lesions or rashes. the cause is not known.

MalaCards: Lichen Planus, also known as lichen, ruber planus, is related to oral lichen planus and hepatitis c. An important gene associated with Lichen Planus is CXCR3 (chemokine (C-X-C motif) receptor 3), and among its related pathways are Integrin Pathway and Signaling by GPCR. The compounds retinoic acid and calcium have been mentioned in the context of this disorder. Affiliated tissues include skin, tongue or and skin, and related mouse phenotypes are immune system and hematopoietic system.

Wikipedia:64 Lichen planus (LP) is a disease of the skin and/or mucous membranes that resembles lichen. It is thought... more...

Aliases & Classifications for Lichen Planus

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 27ICD9CM, 35MeSH, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin


Aliases & Descriptions:

lichen planus 8 10 45 61
lichen, ruber planus 8
lichen ruber planus 8
lichen planus nos 8


External Ids:

Disease Ontology8 DOID:9201
ICD9CM27 697.0
MeSH35 D008010
NCIt40 C3189
ICD1025 L43

Related Diseases for Lichen Planus

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Lichen Planus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 278)
idRelated DiseaseScoreTop Affiliating Genes
1oral lichen planus32.3MMP1, IL1A, CXCR3, CD58, ICAM1, CCL5
2hepatitis c31.3CXCR3, CD58
3leukoplakia31.2FLG, DEFB4A, KRT1, KRT13
4squamous cell carcinoma31.2COL17A1, TIMP2, ITGB4, PECAM1, LAMC2, KRT10
5pemphigus31.0DST
6bullous pemphigoid31.0COL17A1, CCL5, ITGB4, ITGAL, FLG, DST
7oral cancer30.8KRT13, MMP1, TIMP2
8alopecia areata30.7IL1A, ICAM1
9atopic dermatitis30.7FLG, DEFB4A
10erythema multiforme30.7ICAM1
11graft versus host disease30.6PECAM1, ITGAL, CCL5
12viral hepatitis30.6ITGAL
13arthritis30.4TIMP2, CCL5, ICAM1, ITGAM, FLG, CD58
14hepatitis b30.4CD58, ITGAL
15adenocarcinoma30.1TIMP2, CCL5, ITGB4, KRT1, KRT13, KRT10
16asthma30.1CCL5, ICAM1, ITGAM, ITGAL, FLG, DEFB4A
17systemic scleroderma30.1TIMP2, CCL5, ICAM1, CD58, IL1A, MMP1
18allergic asthma30.1CCL5, ICAM1, ITGAM, ITGAL, FLG
19systemic lupus erythematosus30.1CCL5, ICAM1, ITGAM, ITGAL, CXCR3
20allergic contact dermatitis30.1ICAM1, FLG, CXCR3
21keratoderma30.1KRT1, KRT16
22vasculitis30.1ITGAM, ICAM1
23epidermolytic hyperkeratosis30.1KRT1, KRT10
24mycosis fungoides30.1ITGAL, CXCR3
25steatocystoma multiplex30.1KRT16, KRT10
26lichen planus pemphigoides11.1
27oral erosive lichen11.0
28lichen planus pigmentosus11.0
29linear lichen planus10.9
30bullous lichen planus10.9
31atrophic lichen planus10.9
32annular lichen planus10.9
33hepatitis a10.8
34oral leukoplakia10.8
35actinic lichen planus10.8
36oral squamous cell carcinoma10.8
37hepatitis e10.8
38alopecia10.7
39lichen sclerosus10.7
40annular atrophic lichen planus10.7
41lichen planus follicularis10.6
42hepatitis c virus10.6
43lichen nitidus10.6
44thymoma10.6
45discoid lupus erythematosus10.6
46twenty-nail dystrophy10.6
47paraneoplastic pemphigus10.6
48vitiligo10.5
49stomatitis10.5
50pemphigus vulgaris10.5

Graphical network of the top 20 diseases related to Lichen Planus:



Diseases related to lichen planus

Clinical Features for Lichen Planus

Drugs & Therapeutics for Lichen Planus

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Lichen Planus

Drug clinical trials:

Search ClinicalTrials for Lichen Planus

Search NIH Clinical Center for Lichen Planus

Search CenterWatch for Lichen Planus

Genetic Tests for Lichen Planus

Anatomical Context for Lichen Planus

Sources:
14FMA, 33MalaCards
See all sources

MalaCards organs/tissues related to Lichen Planus:

33
Skin, Liver, Tongue, Lymph node, Whole blood, Smooth muscle, Colon, Thyroid, Monocytes, Nk cells, T cells, B cells, Endothelial, Fetal liver, Fetal thyroid

FMA organs/tissues related to Lichen Planus:

14
Skin, Tongue or

Animal Models for Lichen Planus or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Lichen Planus

Sources:
51PubMed
See all sources

Articles related to Lichen Planus:

(show top 50)    (show all 1193)
idTitleAuthorsYear
1
Clinical patterns of lichen planopilaris in patients with vulval lichen planus. (24028504)
2014
2
Prompt healing of erosive oral lichen planus lesion after combined corticosteroid treatment with locally injected triamcinolone acetonide plus oral prednisolone. (23537868)
2013
3
Analysis of the expression of heat-shock protein 27 in patients with oral lichen planus. (22747996)
2013
4
The influence of psychological state on oral lichen planus. (24053073)
2013
5
Proliferation and apoptosis of peripheral blood mononuclear cells in patients with oral lichen planus. (23135214)
2013
6
Hydroxychloroquine niosomes: a new trend in topical management of oral lichen planus. (24184035)
2013
7
Role of oxidative stress in malignant transformation of oral lichen planus. (24084408)
2013
8
MicroRNA-137 promoter methylation in oral lichen planus and oral squamous cell carcinoma. (23121285)
2013
9
Clinicopathological features and malignant transformation of oral lichen planus: a 12-years retrospective study. (23116326)
2013
10
Clinical assessment of the efficacy of photodynamic therapy in the treatment of oral lichen planus. (22814895)
2013
11
Individualizing treatment and choice of medication in lichen planus: a step by step approach. (23981330)
2013
12
Cost-effectiveness of personalized plaque control for managing the gingival manifestations of oral lichen planus: a randomized controlled study. (23800196)
2013
13
Psychological profile (anxiety and depression) in patients with oral lichen planus: a controlled study. (23518775)
2013
14
Reaction to biological drugs: infliximab for the treatment of toxic epidermal necrolysis subsequently triggering erosive lichen planus. (22548502)
2012
15
Acrosyringeal lichen planus of palm. (22772646)
2012
16
Radiotherapy-induced koebnerization in lichen planus. (22960842)
2012
17
Comparison of periodontal status in gingival oral lichen planus patients and healthy subjects. (22570646)
2012
18
Lymphoma in pregnancy initially diagnosed as vaginal intraepithelial neoplasia and lichen planus. (21768862)
2011
19
Enhanced expression of Toll-like receptor 2 in lesional tissues and peripheral blood monocytes of patients with oral lichen planus. (21544941)
2011
20
Graham-little piccardi lassueur syndrome: an unusual variant of follicular lichen planus. (21769233)
2011
21
DNA ploidy in oral lichen planus, determined by image cytometry. (19943857)
2010
22
Increased expression of Smad proteins, and in particular Smad3, in oral lichen planus compared to normal oral mucosa. (20618616)
2010
23
Oxidative stress and antioxidant defense in oral lichen planus and oral lichenoid reaction. (20233035)
2010
24
Comparison of the effect of combination of triamcinolone acetonide and vitamin a mouthwash with triamcinolone mouthwash alone on oral lichen planus. (22991590)
2010
25
Punctate keratotic papules and plaques over palm. Diagnosis: Hypertrophic lichen planus of palm. (20657148)
2010
26
Carriage rate and virulence attributes of oral Candida albicans isolates from patients with oral lichen planus: a study in an ethnic Chinese cohort. (18627473)
2009
27
Association of polymorphisms in the tumor necrosis factor-alpha and interleukin-10 genes with oral lichen planus: a study in a chinese cohort with Han ethnicity. (19450147)
2009
28
Chromosomal numerical aberrations in oral lichen planus. (19493885)
2009
29
Results of patch testing in patients diagnosed with oral lichen planus. (19298777)
2009
30
Miconazole as adjuvant therapy for oral lichen planus: a double-blind randomized controlled trial. (17535232)
2007
31
Oral lichen planus: a case series with emphasis on therapy. (17438185)
2007
32
Oral lichen planus: clinical and histological evaluation in an open trial using a low molecular weight heparinoid (sulodexide). (16911394)
2006
33
The vulvovaginal gingival syndrome: a severe subgroup of lichen planus with characteristic clinical features and a novel association with the class II HLA DQB1*0201 allele. (16781300)
2006
34
HER-2/neu expression in plasma and biopsy of patients with oral lichen planus in comparison to leukoplakia. (16922972)
2006
35
Apoptosis and cell cycle arrest in oral lichen planus Hypothesis on their possible influence on its malignant transformation. (16137496)
2005
36
Current controversies in oral lichen planus: report of an international consensus meeting. Part 1. Viral infections and etiopathogenesis. (15953916)
2005
37
Oral lichen planus in childhood. (16060863)
2005
38
Atrophic lichen planus. (15022509)
2004
39
Oral mucosal keratinocytes express RANTES and ICAM-1, but not interleukin-8, in oral lichen planus and oral lichenoid reactions induced by amalgam fillings. (12558634)
2003
40
Keratoacanthoma developing in hypertrophic lichen planus. (12653757)
2003
41
Erosive oral lichen planus with genital lesions: the vulvovaginal-gingival syndrome and the peno-gingival syndrome. (12622271)
2003
42
Lichen planus pemphigoides with circulating autoantibodies against 200 and 180 kDa epidermal antigens. (10725820)
2000
43
Altered expression of extracellular matrix proteins and integrins in oral lichen planus (OLP). (7540204)
1995
44
Linear lichen planus mimicking creeping eruption. (8478485)
1993
45
Class I and II HLA antigens in British patients with oral lichen planus. (8426716)
1993
46
Lichen planus pemphigoides in a 10-year-old girl. (1732320)
1992
47
Bullous lichen planus and lichen planus pemphigoides. (3208930)
1988
48
Pseudopelade of Brocq secondary to lichen planus. (797544)
1976
49
Lichen planus pemphigoides with extensive melanosis. Occurrence in a patient with malignant lymphoma. (5120164)
1971
50
Atrophic Lichen Planus with Cornu Cutaneum. (19974954)
1911

Genetic Variations for Lichen Planus

Expression for genes affiliated with Lichen Planus

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Lichen Planus

Search GEO for disease gene expression data for Lichen Planus.

Pathways for genes affiliated with Lichen Planus

Sources:
52QIAGEN, 54Reactome, 30KEGG, 12EMD Millipore, 38NCBI BioSystems Database
See all sources

Pathways related to Lichen Planus according to GeneCards/GeneDecks:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.9PECAM1, COL17A1, CCL5, ICAM1, ITGB4, ITGAM
2
Hide members
10.8CCL5, ICAM1, ITGB4, ITGAM, ITGAL, CXCR3
3
Hide members
10.8TIMP2, CCL5, ITGB4, ITGAM, ITGAL, CXCR3
4
Hide members
10.7ICAM1, ITGB4, ITGAM, ITGAL, LAMC2, PECAM1
5
Hide members
10.7TIMP2, ITGB4, ITGAM, ITGAL, CXCR3, LAMC2
6
Hide members
10.7COL17A1, TIMP2, ITGB4, DST, MMP1, LAMC2
7
Hide members
10.7TIMP2, CCL5, ITGB4, ITGAM, ITGAL, IL1A
810.7ICAM1, ITGAM, ITGAL, CD58, PECAM1
910.7ITGAM, ITGAL, CD58, MMP1, PECAM1
1010.7DST, KRT16, KRT1, KRT13
1110.7KRT10, ITGAL, ITGAM, ICAM1
1210.7ICAM1, ITGAM, ITGAL, PECAM1
1310.7COL17A1, ITGB4, DST, LAMC2
1410.7COL17A1, ITGB4, DST, LAMC2
15
Hide members
10.7COL17A1, ITGB4, DST, LAMC2
16
Hide members
10.7LAMC2, ITGAL, ITGB4, COL17A1
17
Hide members
10.6ITGB4, ITGAM, ITGAL, LAMC2
18
Hide members
10.6ITGB4, ITGAM, ITGAL, LAMC2
1910.6ICAM1, ITGAM, ITGAL
2010.6IL1A, ITGB4, COL17A1
21
Cell adhesion Cell-matrix glycoconjugates
Hide members
10.6MMP1, CCL5, TIMP2
22
Cell adhesion ECM remodeling
Hide members
10.6LAMC2, MMP1, TIMP2
2310.6ITGAL, ITGAM, ITGB4
2410.6ITGAL, ITGAM, ITGB4
2510.6PECAM1, ITGAL
2610.5ITGAL

Compounds for genes affiliated with Lichen Planus

Sources:
45Novoseek, 24HMDB, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 29IUPHAR, 2BitterDB
See all sources

Compounds related to Lichen Planus according to GeneCards/GeneDecks:

(show top 50)    (show all 110)
idCompoundScoreTop Affiliating Genes
1retinoic acid45 2412.6PECAM1, TIMP2, CCL5, ICAM1, ITGB4, ITGAM
2calcium45 50 11 2414.6ITGAL, ITGAM, ITGB4, CCL5, TIMP2, COL17A1
3tyrosine4511.5ITGB4, ICAM1, CCL5, TIMP2, COL17A1, ITGAM
4serine4511.5COL17A1, TIMP2, CCL5, ITGB4, ITGAM, FLG
5nitric oxide45 11 2413.4TIMP2, CCL5, ICAM1, ITGB4, ITGAM, ITGAL
6paraffin4511.3TIMP2, DEFB4A, DST, MMP1, KRT16, KRT1
7rantes4511.3ICAM1, ITGAM, ITGAL, DEFB4A, CD58, CXCR3
8calcitriol45 60 11 2414.3CCL5, ITGAM, ITGAL, FLG, IL1A, MMP1
9cyclosporin a45 29 6013.2TIMP2, CCL5, ICAM1, ITGAM, ITGAL, IL1A
10heparin45 29 11 2414.2TIMP2, CCL5, ITGAM, ITGAL, DEFB4A, CXCR3
11matrigel4511.2TIMP2, CCL5, ICAM1, ITGB4, CXCR3, MMP1
12steroid4511.2COL17A1, TIMP2, FLG, DEFB4A, CXCR3, KRT16
13calcipotriol45 60 29 1114.2ICAM1, ITGB4, FLG, IL1A, KRT16, KRT10
14h2o24511.2TIMP2, CCL5, ICAM1, ITGAM, ITGAL, IL1A
15sb 20358045 6012.2TIMP2, CCL5, ICAM1, ITGAM, DEFB4A, IL1A
16pd 98,0594511.2TIMP2, CCL5, ICAM1, ITGAM, DEFB4A, CXCR3
17vegf4511.2TIMP2, CCL5, ICAM1, ITGAM, CXCR3, IL1A
18proline4511.2COL17A1, CCL5, ITGAL, KRT16, KRT1, KRT13
19lipid4511.2TIMP2, CCL5, ITGAM, ITGAL, FLG, DEFB4A
20genistein45 29 60 2 11 2416.1TIMP2, CCL5, ICAM1, ITGAM, DEFB4A, IL1A
21cytochalasin d45 6012.1TIMP2, CCL5, ICAM1, ITGAL, MMP1, PECAM1
22hyaluronic acid45 2412.1TIMP2, ICAM1, ITGAL, CD58, IL1A, MMP1
23dexamethasone45 50 29 1114.1CCL5, ITGAM, ITGAL, DEFB4A, CD58
24fmlp4511.1CCL5, ICAM1, ITGAM, ITGAL, CXCR3, IL1A
25slex4511.1ICAM1, ITGAM, ITGAL, CD58, PECAM1
26retinoid4511.1ITGAM, FLG, MMP1, KRT16, KRT1, KRT10
27endotoxin4511.1CXCR3, DEFB4A, ITGAM, ICAM1
28dithranol4511.1ICAM1, FLG, KRT16, KRT10
29pravastatin45 50 29 11 2415.1TIMP2, ICAM1, ITGAL, IL1A, MMP1
30ascorbic acid45 2412.1TIMP2, ICAM1, ITGAM, FLG, IL1A, MMP1
31progesterone45 60 29 11 2415.0TIMP2, DEFB4A, CXCR3, IL1A, MMP1, KRT1
32histamine45 29 2413.0CCL5, ICAM1, ITGAM, DEFB4A, CXCR3, PECAM1
33hematoxylin4511.0MMP1, KRT1, KRT10, PECAM1
3412-o-tetradecanoylphorbol 13-acetate4511.0TIMP2, ITGAM, DST, IL1A, MMP1, KRT1
35cycloheximide4511.0COL17A1, ITGAM, DST
36fibrinogen4511.0TIMP2, ICAM1, ITGAM, ITGAL, FLG, PECAM1
37groalpha4511.0CCL5, ICAM1, CXCR3, IL1A
38simvastatin45 50 60 29 11 2416.0CCL5, ICAM1, ITGAM, ITGAL, IL1A
39pge24510.9ITGAL
40tarc4510.9IL1A, CXCR3, ICAM1, CCL5
41n-formylmethionyl-leucylphenylalanine4510.9IL1A, ITGAL, ITGAM, ICAM1
42kalinin4510.8ITGB4, DST, LAMC2
43ccl345 2911.8CCL5, ICAM1, CXCR3, IL1A
44nicotine45 50 29 1113.8ICAM1, FLG, IL1A, MMP1, KRT1
45pentoxifylline45 1111.8ICAM1, ITGAM, IL1A, MMP1
46cysteine4510.7TIMP2, CCL5, ITGAM, ITGAL, FLG, DEFB4A
47estrogen4510.7DEFB4A
48fluvastatin45 50 29 1113.7ICAM1, ITGAL, IL1A, MMP1
49pdtc4510.6MMP1, IL1A, CCL5
50aspirin45 50 29 2413.4CCL5, ITGAM, ITGAL, MMP1, PECAM1

GO Terms for genes affiliated with Lichen Planus

Sources:
16Gene Ontology
See all sources

Cellular components related to Lichen Planus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.8TIMP2, CCL5, DEFB4A, IL1A, MMP1, LAMC2
2basement membraneGO:00560410.8DST, ITGB4, TIMP2, COL17A1
3hemidesmosomeGO:03005610.8DST, ITGB4, COL17A1
4intermediate filamentGO:00588210.7FLG, DST, KRT16, KRT10
5integrin complexGO:00830510.6ITGAL, ITGAM, ITGB4
6external side of plasma membraneGO:00989710.6ICAM1, ITGAM, ITGAL, CXCR3
7keratin filamentGO:04509510.3KRT10, KRT13, KRT1

Biological processes related to Lichen Planus according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1cell adhesionGO:00715511.2PECAM1, ICAM1, ITGB4, ITGAM, ITGAL, DST
2leukocyte migrationGO:05090011.0ICAM1, ITGAM, ITGAL, CD58, MMP1, PECAM1
3extracellular matrix organizationGO:03019811.0COL17A1, TIMP2, ITGB4, DST, MMP1, LAMC2
4hemidesmosome assemblyGO:03158110.9COL17A1, ITGB4, DST, LAMC2
5leukocyte cell-cell adhesionGO:00715910.9ITGAL, ITGAM, ICAM1, CCL5
6integrin-mediated signaling pathwayGO:00722910.9ITGB4, ITGAM, ITGAL, DST
7epidermis developmentGO:00854410.9LAMC2, KRT13, KRT16, COL17A1
8blood coagulationGO:00759610.8PECAM1, MMP1, CD58, ITGAL, ITGAM
9T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cellGO:00229110.7ICAM1, ITGAL
10activated T cell proliferationGO:05079810.7ITGAM, ITGAL
11inflammatory responseGO:00695410.7IL1A, CXCR3, ITGAL, CCL5
12intermediate filament cytoskeleton organizationGO:04510410.6DST, KRT16
13cell junction assemblyGO:03432910.6LAMC2, ITGB4, COL17A1
14extracellular matrix disassemblyGO:02261710.5COL17A1, TIMP2, MMP1
15response to copper ionGO:04668810.3IL1A, ICAM1

Molecular functions related to Lichen Planus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integrin bindingGO:00517810.6DST, ICAM1, TIMP2

Products for genes affiliated with Lichen Planus

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lichen Planus

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet