MCID: LCH002
MIFTS: 61

Lichen Planus malady

Skin diseases, Oral diseases categories
Download this MalaCard

Summaries for Lichen Planus

About this section
Sources:
8Disease Ontology, 65Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard
Disease Ontology:8 A lichen disease that is located in skin, located in tongue or located in oral mucosa, which presents itself in the form of papules, lesions or rashes. the cause is not known.

MalaCards: Lichen Planus, also known as lichen, ruber planus, is related to oral lichen planus and leukoplakia. An important gene associated with Lichen Planus is CXCR3 (chemokine (C-X-C motif) receptor 3), and among its related pathways are Immune response Role of integrins in NK cells cytotoxicity and Cytoskeleton remodeling Keratin filaments. The compounds dimethyl fumarate and anti-histamine have been mentioned in the context of this disorder. Affiliated tissues include tongue or, skin and skin, and related mouse phenotypes are integument and homeostasis/metabolism.

Wikipedia:65 Lichen planus (LP) is a disease of the skin and/or mucous membranes that resembles lichen. The cause is... more...

Aliases & Classifications for Lichen Planus

About this section
Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 27ICD9CM, 40NCIt, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases, Oral diseases


Aliases & Descriptions:

lichen planus 8 10 45 62
lichen, ruber planus 8
lichen ruber planus 8
lichen planus nos 8


External Ids:

Disease Ontology8 DOID:9201
ICD9CM27 697.0
NCIt40 C3189
MeSH35 D008010
ICD1025 L43

Related Diseases for Lichen Planus

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Lichen Planus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 240)
idRelated DiseaseScoreTop Affiliating Genes
1oral lichen planus32.3CD58, CCL5, ICAM1, CXCR3
2leukoplakia31.3DEFB4A, FLG, KRT1, KRT13
3keratosis31.0KRT10, FLG, KRT1, KRT16
4dermatitis31.0FLG, CXCR3, ICAM1, KRT16
5bullous pemphigoid30.7FLG, COL17A1, LAMC2, CCL5
6psoriasis30.7DEFB4A, FLG, CXCR3, ICAM1, CCL5, KRT10
7papilloma30.7KRT13, KRT10, FLG
8contact dermatitis30.7FLG
9atopic dermatitis30.6CXCR3, ITGAM, DEFB4A, ICAM1, CCL5, FLG
10melanoma30.5CD58, PECAM1, LAMC2, ICAM1, CXCR3
11epidermolysis bullosa30.4COL17A1, FLG, LAMC2
12sarcoidosis30.4CXCR3, DEFB4A, ICAM1, CCL5, ITGAM
13steatocystoma multiplex30.3KRT16, KRT10
14epidermolytic hyperkeratosis30.3KRT10, KRT1
15keratoderma30.3KRT16, KRT1
16allergic contact dermatitis30.2FLG, CXCR3, ICAM1
17systemic scleroderma30.2CCL5, CD58, ICAM1
18systemic lupus erythematosus30.2ITGAM, ICAM1, CCL5, CXCR3
19pneumonia30.2DEFB4A, ITGAM, CCL5, ICAM1
20hepatocellular carcinoma30.1KRT13, CD58, CCL5, KRT1
21arthritis30.1CD58, PECAM1, ITGAM, CCL5, FLG, CXCR3
22rheumatoid arthritis30.1PECAM1, FLG, CXCR3, CD58, ICAM1, CCL5
23allergic asthma30.1CCL5, ICAM1, FLG, ITGAM
24asthma30.0FLG, CXCR3, DEFB4A, CCL5, ITGAM, ICAM1
25adenocarcinoma30.0CCL5, KRT10, KRT13, PECAM1, KRT1, LAMC2
26lichen planus pemphigoides11.1
27hepatitis11.0
28lichen planus pigmentosus11.0
29hepatitis c11.0
30linear lichen planus10.9
31bullous lichen planus10.9
32atrophic lichen planus10.9
33oral erosive lichen10.9
34actinic lichen planus10.8
35hepatitis c virus10.8
36annular lichen planus10.8
37pemphigus10.7
38annular atrophic lichen planus10.7
39gingivitis10.7
40lupus erythematosus10.7
41oral squamous cell carcinoma10.7
42alopecia10.7
43lichen sclerosus10.7
44oral leukoplakia10.7
45lichen planus follicularis10.7
46lichen nitidus10.6
47esophagitis10.6
48blindness10.6
49vulvovaginitis10.6
50thymoma10.6

Graphical network of the top 20 diseases related to Lichen Planus:



Diseases related to lichen planus

Symptoms for Lichen Planus

About this section

Drugs & Therapeutics for Lichen Planus

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Lichen Planus

Search NIH Clinical Center for Lichen Planus

Genetic Tests for Lichen Planus

About this section

Anatomical Context for Lichen Planus

About this section
Sources:
33MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Lichen Planus:

33
Skin, Tongue, T cells, Endothelial, Thyroid, Liver, Testes, B cells, Nk cells, Monocytes, Colon, Smooth muscle, Lymph node

FMA organs/tissues related to Lichen Planus:

14
Tongue or, Skin

Animal Models for Lichen Planus or affiliated genes

About this section
Sources:
37MGI
See all sources

MGI Mouse Phenotypes related to Lichen Planus:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107717.8LAMC2, FLG, ICAM1, COL17A1, KRT10, KRT1
2MP:00053767.3FLG, CXCR3, ICAM1, ITGAM, KRT1, KRT16
3MP:00107687.2LAMC2, FLG, CXCR3, ICAM1, COL17A1, KRT10
4MP:00053977.0PECAM1, FLG, CXCR3, ICAM1, CCL5, ITGAM
5MP:00053876.0KRT1, PECAM1, LAMC2, FLG, CXCR3, ICAM1

Publications for Lichen Planus

About this section
Sources:
52PubMed
See all sources

Articles related to Lichen Planus:

(show top 50)    (show all 1174)
idTitleAuthorsYear
1
Prompt healing of erosive oral lichen planus lesion after combined corticosteroid treatment with locally injected triamcinolone acetonide plus oral prednisolone. (23537868)
2013
2
Homocysteine and other cardiovascular risk factors in patients with lichen planus. (24330130)
2013
3
CIITA rs4774 and rs6498122 polymorphisms are associated with oral lichen planus in Chinese people: a case-control study. (23489895)
2013
4
Oral lichen planus in Arab countries : a review. (24245546)
2013
5
Wickham's striae presented with whitish ring-form on annular lichen planus. (24330176)
2013
6
A case of lichen planus pemphigoides successfully treated with a combination of cyclosporine a and prednisolone. (23626545)
2013
7
Levels of potential oral cancer salivary mRNA biomarkers in oral cancer patients in remission and oral lichen planus patients. (23892499)
2013
8
Altered expression of miR-21, miR-125b, and miR-203 indicates a role for these microRNAs in oral lichen planus. (21943223)
2012
9
Lichen planus and cicatricial conjunctivitis: disease course and response to therapy of 11 patients. (20477930)
2011
10
Lichen planus of the larynx. (21272411)
2011
11
A Case of Lichen Planus Pigmentosus-inversus in a Korean Patient. (21738364)
2011
12
HLA-C/KIR genotypes in oral lichen planus patients infected or non-infected with hepatitis C virus. (20860769)
2011
13
Immunohistochemical assessment of angiogenesis and vascular endothelial growth factor expression in cutaneous lichen planus: relation to the degree of inflammation. (21414893)
2011
14
Circumscribed lenticular anetoderma in an HIV-infected man with a history of syphilis and lichen planus. (22031628)
2011
15
Lichen planus pigmentosus over superficial leg veins. (21251228)
2011
16
Cardiovascular risk factors in patients with lichen planus. (21605731)
2011
17
Heterogeneous disease: a child case of lichen planus pemphigoides triggered by varicella. (21453319)
2011
18
Lichen planus with palmoplantar involvement: rapid therapeutic response to acitretin. (21865117)
2011
19
Lichen planus pemphigoides, a possible example of epitope spreading. (20382044)
2010
20
The quality of patient-orientated Internet information on oral lichen planus: a pilot study. (20586847)
2010
21
In situ amelanotic melanoma of the nail unit mimicking lichen planus: report of 3 cases. (20404232)
2010
22
A retrospective clinicopathological study of 550 patients with oral lichen planus in south-eastern Spain. (20456611)
2010
23
Premalignant nature of oral and vulval lichen planus: facts and controversies. (20797520)
2010
24
Imiquimod use in the genital area and development of lichen sclerosus and lichen planus. (20215634)
2010
25
Wolf's isotopic response: large annular polycyclic lichen planus occurring on healed lesions of dermatophytosis. (18624876)
2009
26
LCK, survivin and PI-3K in the molecular biomarker profiling of oral lichen planus and oral squamous cell carcinoma. (20975919)
2009
27
Carriage rate and virulence attributes of oral Candida albicans isolates from patients with oral lichen planus: a study in an ethnic Chinese cohort. (18627473)
2009
28
Evaluation of salivary cortisol and psychological factors in patients with oral lichen planus. (19884710)
2009
29
Lichen planus pemphigoides in a 6-year-old child. (19086935)
2009
30
Annular atrophic lichen planus. (17472678)
2007
31
Survival signalling in keratinocytes of erythematous oral lichen planus. (17391299)
2007
32
A combined treatment regimen for desquamative gingivitis in patients with oral lichen planus. (17238974)
2007
33
DNA cytometry of oral leukoplakia and oral lichen planus. (15800471)
2005
34
Linear lichen planus of the face and neck versus amalgam-induced "isotopic" cutaneous lichen planus. (15692500)
2005
35
Annular lichen planus. (15578131)
2004
36
Oral mucosal keratinocytes express RANTES and ICAM-1, but not interleukin-8, in oral lichen planus and oral lichenoid reactions induced by amalgam fillings. (12558634)
2003
37
Linear lichen planus related to hepatitis C infection? (10792256)
2000
38
An atypical verrucous carcinoma of the tongue arising in a patient with oral lichen planus associated with hepatitis C virus infection. (9307733)
1997
39
Apoptosis-associated markers in oral lichen planus. (9176791)
1997
40
Altered interface adhesion molecules in oral lichen planus. (9081757)
1996
41
Hepatitis C and its association with lichen planus and porphyria cutanea tarda. (7868738)
1995
42
Appearance of oral erosive lichen planus during interferon alfa-2a therapy for chronic active hepatitis C. (7650248)
1995
43
Effectiveness of a low dose of cyclosporine in the management of patients with oral erosive lichen planus. (7552878)
1995
44
Hepatitis C virus infection and oral erosive lichen planus. (7798440)
1994
45
Actinic lichen planus. A clinicopathologic study of 16 patients. (2915056)
1989
46
Bullous lichen planus developed on erythema ab igne. (3537047)
1986
47
Bullous lichen planus: diagnosis by indirect immunofluorescence and treatment with dapsone. (3514699)
1986
48
Bullous lichen planus after intravenous pyelography. (2932478)
1985
49
Deep keratitis associated with atypical lichen planus; report of a case. (18106939)
1948
50
Poikiloderma Jacobi? atrophic lichen planus? (20993126)
1946

Variations for Lichen Planus

About this section

Expression for genes affiliated with Lichen Planus

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Lichen Planus

Search GEO for disease gene expression data for Lichen Planus.

Pathways for genes affiliated with Lichen Planus

About this section
Sources:
50PathCards, 60Thomson Reuters, 30KEGG, 55Reactome, 53QIAGEN
See all sources

Compounds for genes affiliated with Lichen Planus

About this section
Sources:
45Novoseek, 11DrugBank, 24HMDB, 29IUPHAR, 61Tocris Bioscience, 51PharmGKB, 3BitterDB
See all sources

Compounds related to Lichen Planus according to GeneCards/GeneDecks:

(show top 50)    (show all 76)
idCompoundScoreTop Affiliating Genes
1dimethyl fumarate4510.3ICAM1, CXCR3
2anti-histamine4510.0CCL5, ICAM1
3tazarotene45 1111.0KRT10, KRT1
4isotretinoin45 1110.9KRT10, KRT1, KRT16
5groalpha459.8CXCR3, CCL5, ICAM1
6tarc459.8CXCR3, CCL5, ICAM1
7loratadine45 24 1111.8CCL5, ICAM1
8ccl345 2910.8CCL5, ICAM1, CXCR3
9mcp 1459.8CXCR3, CCL5
10sp 60012545 6110.7ICAM1, DEFB4A, CCL5
115-oxoete459.7ITGAM, CCL5
12dithranol459.5ICAM1, FLG, KRT16, KRT10
13calcipotriol45 61 29 1112.5KRT16, KRT10, ICAM1, FLG
14fmlp459.3CXCR3, CCL5, ITGAM, ICAM1
15gf 109203x45 6110.3FLG, CCL5, KRT10
16ly294002459.2CCL5, ICAM1, CXCR3, ITGAM
17sb 20358045 6110.2DEFB4A, CCL5, ITGAM, ICAM1
18vitamin d459.2KRT13, KRT10, ITGAM, CCL5
19simvastatin45 51 61 29 24 1114.2CCL5, ICAM1, ITGAM
20genistein45 29 61 3 24 1114.1ITGAM, CCL5, ICAM1, DEFB4A
21pge2459.1ICAM1, ITGAM, CXCR3, CCL5
22endotoxin459.1CXCR3, ICAM1, CCL5, ITGAM, DEFB4A
23p002459.1DEFB4A, PECAM1, ITGAM
24pd 98,059459.0CCL5, ICAM1, ITGAM, CXCR3, DEFB4A
25matrigel459.0CCL5, ICAM1, CXCR3, PECAM1
26slex459.0PECAM1, ITGAM, CD58, ICAM1
27bromodeoxyuridine458.9FLG, KRT10, KRT1
28hematoxylin458.8KRT1, KRT10, PECAM1, FLG
29cytochalasin d45 619.8CCL5, ICAM1, PECAM1
30retinoid458.8KRT10, ITGAM, KRT16, KRT1, FLG
31proline458.7KRT13, CCL5, KRT16, KRT1, KRT10, COL17A1
32calcitriol45 61 24 1111.6KRT10, FLG, CCL5, ITGAM, KRT16
33cyclosporin a45 29 6110.6PECAM1, ICAM1, CCL5, ITGAM
34fibrinogen458.6PECAM1, ICAM1, FLG, ITGAM
35paraffin458.5KRT16, DEFB4A, KRT1, PECAM1, KRT13, KRT10
36dexamethasone45 51 29 1111.4DEFB4A, ITGAM, CCL5, CD58, ICAM1, CXCR3
37heparin45 29 24 1111.4ITGAM, CCL5, CXCR3, PECAM1, DEFB4A
38vegf458.4CXCR3, ICAM1, ITGAM, PECAM1, CCL5
39steroid458.4KRT1, KRT16, CXCR3, KRT10, COL17A1, DEFB4A
40estrogen458.3DEFB4A, KRT1, KRT10, CCL5, PECAM1, CXCR3
41cycloheximide458.3CCL5, PECAM1, ITGAM, COL17A1, ICAM1
42histamine45 29 2410.2DEFB4A, CXCR3, ICAM1, CCL5, PECAM1, ITGAM
43rantes457.9ICAM1, CCL5, DEFB4A, PECAM1, CXCR3, CD58
44cysteine457.7ITGAM, DEFB4A, PECAM1, CCL5, FLG
45nitric oxide45 24 119.6KRT16, ITGAM, PECAM1, FLG, ICAM1, CXCR3
46lipid457.4PECAM1, FLG, DEFB4A, CCL5, ITGAM, KRT1
47serine456.8CXCR3, CCL5, FLG, ITGAM, COL17A1, KRT10
48tyrosine456.6DEFB4A, PECAM1, FLG, CXCR3, ICAM1, CCL5
49calcium45 51 24 119.5KRT13, KRT1, KRT10, COL17A1, ITGAM, CCL5
50retinoic acid45 247.3CCL5, PECAM1, ICAM1, FLG, ITGAM, KRT10

GO Terms for genes affiliated with Lichen Planus

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Lichen Planus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1keratin filamentGO:0450959.6KRT10, KRT1, KRT13
2intermediate filamentGO:0058829.2KRT16, KRT10, FLG
3external side of plasma membraneGO:0098979.2CXCR3, ICAM1, ITGAM
4extracellular vesicular exosomeGO:0700627.9CD58, PECAM1, ICAM1, KRT10, KRT1, KRT16
5extracellular spaceGO:0056157.8PECAM1, LAMC2, ICAM1, CCL5, KRT10, KRT1
6plasma membraneGO:0058867.5CXCR3, ICAM1, ITGAM, COL17A1, KRT1, CD58

Biological processes related to Lichen Planus according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1cellular response to interleukin-1GO:0713479.7CCL5, ICAM1
2hemidesmosome assemblyGO:0315819.5COL17A1, LAMC2
3cellular response to tumor necrosis factorGO:0713569.5CD58, CCL5, ICAM1
4chemotaxisGO:0069359.4DEFB4A, CXCR3, CCL5
5epidermis developmentGO:0085449.4KRT16, COL17A1, LAMC2
6leukocyte cell-cell adhesionGO:0071599.3ICAM1, CCL5, ITGAM
7cellular response to interferon-gammaGO:0713469.3CD58, CCL5
8leukocyte migrationGO:0509008.7CD58, ITGAM, ICAM1, PECAM1
9extracellular matrix organizationGO:0301988.2PECAM1, LAMC2, ICAM1, ITGAM, COL17A1
10cell adhesionGO:0071558.1CD58, ITGAM, ICAM1, CXCR3, LAMC2, PECAM1

Molecular functions related to Lichen Planus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor activityGO:0048729.6KRT1, ICAM1, CXCR3
2structural molecule activityGO:0051988.9KRT13, KRT1, FLG

Products for genes affiliated with Lichen Planus

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lichen Planus

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet