MCID: LCH002
MIFTS: 62

Lichen Planus malady

Skin diseases, Oral diseases categories
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Summaries for Lichen Planus

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Disease Ontology:8 A lichen disease that is located in skin, located in tongue or located in oral mucosa, which presents itself in the form of papules, lesions or rashes. the cause is not known.

MalaCards based summary: Lichen Planus, also known as lichen ruber planus, is related to oral lichen planus and leukoplakia. An important gene associated with Lichen Planus is CXCR3 (chemokine (C-X-C motif) receptor 3), and among its related pathways are Immune response Role of integrins in NK cells cytotoxicity and Cytoskeleton remodeling Keratin filaments. The compounds dimethyl fumarate and anti-histamine have been mentioned in the context of this disorder. Affiliated tissues include skin, tongue or and skin, and related mouse phenotypes are integument and homeostasis/metabolism.

Wikipedia:65 Lichen planus (LP) is a disease of the skin and/or mucous membranes that resembles lichen. The cause is... more...

Aliases & Classifications for Lichen Planus

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 39NCIt, 57SNOMED-CT, 34MeSH, 27ICD9CM, 25ICD10
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Lichen Planus, Aliases & Descriptions:

Name: Lichen Planus 8 10 44 62
Lichen Ruber Planus 8 62
 
Lichen, Ruber Planus 8
Lichen Planus Nos 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases, Oral diseases


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Disease Ontology8 DOID:9201
NCIt39 C3189
MeSH34 D008010
ICD9CM27 697.0
ICD1025 L43

Related Diseases for Lichen Planus

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Diseases related to Lichen Planus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 241)
idRelated DiseaseScoreTop Affiliating Genes
1oral lichen planus32.4CD58, CCL5, ICAM1, CXCR3
2leukoplakia31.3DEFB4A, FLG, KRT1, KRT13
3contact dermatitis31.2FLG
4dermatitis31.1FLG, CXCR3, ICAM1, KRT16
5keratosis31.1KRT16, KRT1, KRT10, FLG
6mucous membrane pemphigoid31.1LAMC2, COL17A1
7papilloma31.0KRT13, KRT10, FLG
8steatocystoma multiplex30.8KRT16, KRT10
9epidermolytic hyperkeratosis30.8KRT10, KRT1
10keratoderma30.7KRT16, KRT1
11bullous pemphigoid30.6COL17A1, CCL5, FLG, LAMC2
12allergic contact dermatitis30.5FLG, CXCR3, ICAM1
13epidermolysis bullosa30.5LAMC2, FLG, COL17A1
14systemic scleroderma30.4ICAM1, CCL5, CD58
15sarcoidosis30.3DEFB4A, CXCR3, ICAM1, CCL5, ITGAM
16melanoma30.2PECAM1, LAMC2, CXCR3, ICAM1, CD58
17systemic lupus erythematosus30.2CXCR3, ICAM1, CCL5, ITGAM
18pneumonia30.2DEFB4A, ICAM1, CCL5, ITGAM
19atopic dermatitis30.2DEFB4A, FLG, CXCR3, ICAM1, CCL5, ITGAM
20allergic asthma30.0FLG, ICAM1, CCL5, ITGAM
21psoriasis29.7ICAM1, CCL5, KRT10, KRT1, KRT16, KRT13
22asthma29.6DEFB4A, FLG, CXCR3, ICAM1, CCL5, ITGAM
23adenocarcinoma29.4PECAM1, LAMC2, CCL5, KRT10, KRT1, KRT13
24arthritis29.3PECAM1, FLG, CXCR3, ICAM1, CCL5, ITGAM
25rheumatoid arthritis29.3PECAM1, FLG, CXCR3, ICAM1, CCL5, ITGAM
26lichen planus pemphigoides11.1
27lichen planus pigmentosus11.0
28hepatitis11.0
29hepatitis c11.0
30linear lichen planus11.0
31bullous lichen planus10.9
32atrophic lichen planus10.9
33oral erosive lichen10.9
34actinic lichen planus10.8
35hepatitis c virus10.8
36annular lichen planus10.8
37pemphigus10.7
38alopecia10.7
39oral squamous cell carcinoma10.7
40gingivitis10.7
41annular atrophic lichen planus10.7
42lupus erythematosus10.7
43lichen sclerosus10.7
44oral leukoplakia10.7
45lichen planus follicularis10.7
46blindness10.7
47lichen nitidus10.7
48esophagitis10.7
49vulvovaginitis10.6
50thymoma10.6

Graphical network of the top 20 diseases related to Lichen Planus:



Diseases related to lichen planus

Symptoms for Lichen Planus

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Drugs & Therapeutics for Lichen Planus

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Drug clinical trials:

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Genetic Tests for Lichen Planus

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Anatomical Context for Lichen Planus

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MalaCards organs/tissues related to Lichen Planus:

32
Skin, Tongue, T cells, Thyroid, Testes, Liver, Endothelial, Colon, B cells, Lymph node, Smooth muscle, Monocytes, Nk cells

FMA organs/tissues related to Lichen Planus:

14
Skin, Tongue or

Animal Models for Lichen Planus or affiliated genes

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MGI Mouse Phenotypes related to Lichen Planus:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107717.8LAMC2, FLG, ICAM1, COL17A1, KRT10, KRT1
2MP:00053767.3FLG, CXCR3, ICAM1, ITGAM, KRT1, KRT16
3MP:00107687.2LAMC2, FLG, CXCR3, ICAM1, COL17A1, KRT10
4MP:00053977.0PECAM1, FLG, CXCR3, ICAM1, CCL5, ITGAM
5MP:00053876.0KRT1, PECAM1, LAMC2, FLG, CXCR3, ICAM1

Publications for Lichen Planus

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Articles related to Lichen Planus:

(show top 50)    (show all 1210)
idTitleAuthorsYear
1
Oral lichen planus with antibodies to desmogleins 1 and 3. (25354571)
2014
2
Successful treatment of lichen planus pemphigoides using acitretin as monotherapy. (25087694)
2014
3
Prompt healing of erosive oral lichen planus lesion after combined corticosteroid treatment with locally injected triamcinolone acetonide plus oral prednisolone. (23537868)
2013
4
Homocysteine and other cardiovascular risk factors in patients with lichen planus. (24330130)
2013
5
CIITA rs4774 and rs6498122 polymorphisms are associated with oral lichen planus in Chinese people: a case-control study. (23489895)
2013
6
Oral lichen planus in Arab countries : a review. (24245546)
2013
7
Wickham's striae presented with whitish ring-form on annular lichen planus. (24330176)
2013
8
A case of lichen planus pemphigoides successfully treated with a combination of cyclosporine a and prednisolone. (23626545)
2013
9
Levels of potential oral cancer salivary mRNA biomarkers in oral cancer patients in remission and oral lichen planus patients. (23892499)
2013
10
Altered expression of miR-21, miR-125b, and miR-203 indicates a role for these microRNAs in oral lichen planus. (21943223)
2012
11
Lichen planus and cicatricial conjunctivitis: disease course and response to therapy of 11 patients. (20477930)
2011
12
Lichen planus of the larynx. (21272411)
2011
13
A Case of Lichen Planus Pigmentosus-inversus in a Korean Patient. (21738364)
2011
14
HLA-C/KIR genotypes in oral lichen planus patients infected or non-infected with hepatitis C virus. (20860769)
2011
15
Immunohistochemical assessment of angiogenesis and vascular endothelial growth factor expression in cutaneous lichen planus: relation to the degree of inflammation. (21414893)
2011
16
Circumscribed lenticular anetoderma in an HIV-infected man with a history of syphilis and lichen planus. (22031628)
2011
17
Lichen planus pigmentosus over superficial leg veins. (21251228)
2011
18
Cardiovascular risk factors in patients with lichen planus. (21605731)
2011
19
Heterogeneous disease: a child case of lichen planus pemphigoides triggered by varicella. (21453319)
2011
20
Lichen planus pemphigoides, a possible example of epitope spreading. (20382044)
2010
21
The quality of patient-orientated Internet information on oral lichen planus: a pilot study. (20586847)
2010
22
In situ amelanotic melanoma of the nail unit mimicking lichen planus: report of 3 cases. (20404232)
2010
23
A retrospective clinicopathological study of 550 patients with oral lichen planus in south-eastern Spain. (20456611)
2010
24
Premalignant nature of oral and vulval lichen planus: facts and controversies. (20797520)
2010
25
Imiquimod use in the genital area and development of lichen sclerosus and lichen planus. (20215634)
2010
26
Wolf's isotopic response: large annular polycyclic lichen planus occurring on healed lesions of dermatophytosis. (18624876)
2009
27
LCK, survivin and PI-3K in the molecular biomarker profiling of oral lichen planus and oral squamous cell carcinoma. (20975919)
2009
28
Carriage rate and virulence attributes of oral Candida albicans isolates from patients with oral lichen planus: a study in an ethnic Chinese cohort. (18627473)
2009
29
Evaluation of salivary cortisol and psychological factors in patients with oral lichen planus. (19884710)
2009
30
Lichen planus pemphigoides in a 6-year-old child. (19086935)
2009
31
Annular atrophic lichen planus. (17472678)
2007
32
Survival signalling in keratinocytes of erythematous oral lichen planus. (17391299)
2007
33
A combined treatment regimen for desquamative gingivitis in patients with oral lichen planus. (17238974)
2007
34
DNA cytometry of oral leukoplakia and oral lichen planus. (15800471)
2005
35
Linear lichen planus of the face and neck versus amalgam-induced "isotopic" cutaneous lichen planus. (15692500)
2005
36
Annular lichen planus. (15578131)
2004
37
Oral mucosal keratinocytes express RANTES and ICAM-1, but not interleukin-8, in oral lichen planus and oral lichenoid reactions induced by amalgam fillings. (12558634)
2003
38
Linear lichen planus related to hepatitis C infection? (10792256)
2000
39
An atypical verrucous carcinoma of the tongue arising in a patient with oral lichen planus associated with hepatitis C virus infection. (9307733)
1997
40
Apoptosis-associated markers in oral lichen planus. (9176791)
1997
41
Altered interface adhesion molecules in oral lichen planus. (9081757)
1996
42
Hepatitis C and its association with lichen planus and porphyria cutanea tarda. (7868738)
1995
43
Appearance of oral erosive lichen planus during interferon alfa-2a therapy for chronic active hepatitis C. (7650248)
1995
44
Hepatitis C virus infection and oral erosive lichen planus. (7798440)
1994
45
Actinic lichen planus. A clinicopathologic study of 16 patients. (2915056)
1989
46
Bullous lichen planus developed on erythema ab igne. (3537047)
1986
47
Bullous lichen planus: diagnosis by indirect immunofluorescence and treatment with dapsone. (3514699)
1986
48
Bullous lichen planus after intravenous pyelography. (2932478)
1985
49
Deep keratitis associated with atypical lichen planus; report of a case. (18106939)
1948
50
Poikiloderma Jacobi? atrophic lichen planus? (20993126)
1946

Variations for Lichen Planus

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Expression for genes affiliated with Lichen Planus

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Expression patterns in normal tissues for genes affiliated with Lichen Planus

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Pathways for genes affiliated with Lichen Planus

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Compounds for genes affiliated with Lichen Planus

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Compounds related to Lichen Planus according to GeneCards/GeneDecks:

(show top 50)    (show all 76)
idCompoundScoreTop Affiliating Genes
1dimethyl fumarate4410.3ICAM1, CXCR3
2anti-histamine4410.0CCL5, ICAM1
3tazarotene44 1111.0KRT10, KRT1
4isotretinoin44 1110.9KRT10, KRT1, KRT16
5groalpha449.8CXCR3, CCL5, ICAM1
6tarc449.8CXCR3, CCL5, ICAM1
7loratadine44 24 1111.8CCL5, ICAM1
8ccl344 2810.8CCL5, ICAM1, CXCR3
9mcp 1449.8CXCR3, CCL5
10sp 60012544 6110.7ICAM1, DEFB4A, CCL5
115-oxoete449.7ITGAM, CCL5
12dithranol449.5ICAM1, FLG, KRT16, KRT10
13calcipotriol44 61 28 1112.5KRT16, KRT10, ICAM1, FLG
14fmlp449.3CXCR3, CCL5, ITGAM, ICAM1
15gf 109203x44 6110.3FLG, CCL5, KRT10
16ly294002449.2CCL5, ICAM1, CXCR3, ITGAM
17sb 20358044 6110.2DEFB4A, CCL5, ITGAM, ICAM1
18vitamin d449.2KRT13, KRT10, ITGAM, CCL5
19simvastatin44 50 61 28 24 1114.2CCL5, ICAM1, ITGAM
20genistein44 28 61 2 24 1114.1ITGAM, CCL5, ICAM1, DEFB4A
21pge2449.1ICAM1, ITGAM, CXCR3, CCL5
22endotoxin449.1CXCR3, ICAM1, CCL5, ITGAM, DEFB4A
23p002449.1DEFB4A, PECAM1, ITGAM
24pd 98,059449.0CCL5, ICAM1, ITGAM, CXCR3, DEFB4A
25matrigel449.0CCL5, ICAM1, CXCR3, PECAM1
26slex449.0PECAM1, ITGAM, CD58, ICAM1
27bromodeoxyuridine448.9FLG, KRT10, KRT1
28hematoxylin448.8KRT1, KRT10, PECAM1, FLG
29cytochalasin d44 619.8CCL5, ICAM1, PECAM1
30retinoid448.8KRT10, ITGAM, KRT16, KRT1, FLG
31proline448.7KRT13, CCL5, KRT16, KRT1, KRT10, COL17A1
32calcitriol44 61 24 1111.6KRT10, FLG, CCL5, ITGAM, KRT16
33cyclosporin a44 28 6110.6PECAM1, ICAM1, CCL5, ITGAM
34fibrinogen448.6PECAM1, ICAM1, FLG, ITGAM
35paraffin448.5KRT16, DEFB4A, KRT1, PECAM1, KRT13, KRT10
36dexamethasone44 50 28 1111.4DEFB4A, ITGAM, CCL5, CD58, ICAM1, CXCR3
37heparin44 28 24 1111.4ITGAM, CCL5, CXCR3, PECAM1, DEFB4A
38vegf448.4CXCR3, ICAM1, ITGAM, PECAM1, CCL5
39steroid448.4KRT1, KRT16, CXCR3, KRT10, COL17A1, DEFB4A
40estrogen448.3DEFB4A, KRT1, KRT10, CCL5, PECAM1, CXCR3
41cycloheximide448.3CCL5, PECAM1, ITGAM, COL17A1, ICAM1
42histamine44 28 2410.2DEFB4A, CXCR3, ICAM1, CCL5, PECAM1, ITGAM
43rantes447.9ICAM1, CCL5, DEFB4A, PECAM1, CXCR3, CD58
44cysteine447.7ITGAM, DEFB4A, PECAM1, CCL5, FLG
45nitric oxide44 24 119.6KRT16, ITGAM, PECAM1, FLG, ICAM1, CXCR3
46lipid447.4PECAM1, FLG, DEFB4A, CCL5, ITGAM, KRT1
47serine446.8CXCR3, CCL5, FLG, ITGAM, COL17A1, KRT10
48tyrosine446.6DEFB4A, PECAM1, FLG, CXCR3, ICAM1, CCL5
49calcium44 50 24 119.5KRT13, KRT1, KRT10, COL17A1, ITGAM, CCL5
50retinoic acid44 247.3CCL5, PECAM1, ICAM1, FLG, ITGAM, KRT10

GO Terms for genes affiliated with Lichen Planus

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Cellular components related to Lichen Planus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1keratin filamentGO:0450959.6KRT1, KRT10, KRT13
2intermediate filamentGO:0058829.2KRT16, KRT10, FLG
3external side of plasma membraneGO:0098979.2CXCR3, ICAM1, ITGAM
4extracellular vesicular exosomeGO:0700627.9PECAM1, ICAM1, KRT10, KRT1, KRT16, KRT13
5extracellular spaceGO:0056157.8KRT1, PECAM1, KRT10, CCL5, ICAM1, LAMC2
6plasma membraneGO:0058867.5CD58, KRT1, COL17A1, ITGAM, ICAM1, PECAM1

Biological processes related to Lichen Planus according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1cellular response to interleukin-1GO:0713479.7CCL5, ICAM1
2hemidesmosome assemblyGO:0315819.5COL17A1, LAMC2
3cellular response to tumor necrosis factorGO:0713569.5CD58, CCL5, ICAM1
4chemotaxisGO:0069359.4CCL5, CXCR3, DEFB4A
5epidermis developmentGO:0085449.4LAMC2, COL17A1, KRT16
6leukocyte cell-cell adhesionGO:0071599.3ICAM1, ITGAM, CCL5
7cellular response to interferon-gammaGO:0713469.3CCL5, CD58
8leukocyte migrationGO:0509008.7PECAM1, ICAM1, ITGAM, CD58
9extracellular matrix organizationGO:0301988.2ITGAM, ICAM1, LAMC2, COL17A1, PECAM1
10cell adhesionGO:0071558.1ICAM1, PECAM1, LAMC2, CD58, ITGAM, CXCR3

Molecular functions related to Lichen Planus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor activityGO:0048729.6KRT1, ICAM1, CXCR3
2structural molecule activityGO:0051988.9KRT13, KRT1, FLG

Products for genes affiliated with Lichen Planus

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Sources for Lichen Planus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet